#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P08603	uniprotkb:Q932F7	intact:EBI-1223708|uniprotkb:A5PL14|uniprotkb:Q2TAZ5|uniprotkb:P78435|uniprotkb:Q14570|uniprotkb:Q38G77|uniprotkb:Q5TFM3|uniprotkb:Q8N708|uniprotkb:Q9NU86|ensembl:ENSP00000356399	intact:EBI-26369465|ensemblbacteria:BAB56725	psi-mi:cfah_human(display_long)|uniprotkb:CFH(gene name)|psi-mi:CFH(display_short)|uniprotkb:HF(gene name synonym)|uniprotkb:HF1(gene name synonym)|uniprotkb:HF2(gene name synonym)|uniprotkb:H factor 1(gene name synonym)	psi-mi:sdre_staam(display_long)|uniprotkb:sdrE(gene name)|psi-mi:sdrE(display_short)|uniprotkb:SAV0563(locus name)	psi-mi:"MI:0114"(x-ray crystallography)	Zhang et al. (2017)	pubmed:28258151|imex:IM-28434	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:158878(staam)|taxid:158878("Staphylococcus aureus (strain Mu50 / ATCC 700699)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-26369488|imex:IM-28434-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000177.2|dip:DIP-38303N|ensembl:ENSG00000000971(gene)|ensembl:ENST00000367429(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006956"(complement activation)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0008201"(heparin binding)|go:"GO:0030449"(regulation of complement activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:1903659"(regulation of complement-dependent cytotoxicity)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|mint:P08603|rcsb pdb:1FHC|rcsb pdb:1HAQ|rcsb pdb:1HCC|rcsb pdb:1HFH|rcsb pdb:1HFI|rcsb pdb:1KOV|rcsb pdb:2QFH|rcsb pdb:2RLP|rcsb pdb:2RLQ|rcsb pdb:2UWN|rcsb pdb:2V8E|rcsb pdb:2W80|rcsb pdb:2BZM|rcsb pdb:2G7I|rcsb pdb:2W81|rcsb pdb:2WII|rcsb pdb:2XQW|rcsb pdb:3GAU|rcsb pdb:3GAV|rcsb pdb:3GAW|rcsb pdb:3KXV|rcsb pdb:3KZJ|rcsb pdb:3OXU|rcsb pdb:3R62|rcsb pdb:3RJ3|rcsb pdb:3SW0|rcsb pdb:4AYD|rcsb pdb:4AYE|rcsb pdb:4AYI|rcsb pdb:4AYM|rcsb pdb:4B2R|rcsb pdb:4B2S|rcsb pdb:2IC4|rcsb pdb:2JGW|rcsb pdb:2JGX|rcsb pdb:4J38|rcsb pdb:4K12|rcsb pdb:4ONT|rcsb pdb:4ZH1|rcsb pdb:5NBQ|rcsb pdb:5O32|rcsb pdb:5O35|rcsb pdb:2KMS|rcsb pdb:2QFG|rcsb pdb:5WTB|rcsb pdb:6ATG|reactome:R-HSA-977606	ensemblbacteria:BAB56725(transcript)|ensemblbacteria:SAV0563(gene)|go:"GO:0005576"(extracellular region)|go:"GO:0005618"(cell wall)|go:"GO:0007155"(cell adhesion)|refseq:WP_000610237.1|rcsb pdb:5WTA|rcsb pdb:5WTB|interpro:IPR011266(Fibrogen-binding, domain 2)|interpro:IPR008966(Adhesion, bacterial)|interpro:IPR011252(Fibrogen-binding, domain 1)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR019931|interpro:IPR033764|interpro:IPR041171|interpro:IPR005877(YSIRK Gram-positive signal peptide)	pdbe:5wtb	-	-	figure legend:F3A F3D T1 SF2B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/10/16	2020/12/03	rogid:1mjo+AJLIQnEsMFqsGsmUFbfUxk9606	rogid:7whrWG4mQYp7Cw6oDDq01h3nOdw158878	rigid:b9mvI93Z8/0tpq6x2HDfRA2OE5c	false	binding-associated region:1206-1226	his tag:n-n|binding-associated region:270-599	2	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P08603	uniprotkb:Q932F7	intact:EBI-1223708|uniprotkb:A5PL14|uniprotkb:Q2TAZ5|uniprotkb:P78435|uniprotkb:Q14570|uniprotkb:Q38G77|uniprotkb:Q5TFM3|uniprotkb:Q8N708|uniprotkb:Q9NU86|ensembl:ENSP00000356399	intact:EBI-26369465|ensemblbacteria:BAB56725	psi-mi:cfah_human(display_long)|uniprotkb:CFH(gene name)|psi-mi:CFH(display_short)|uniprotkb:HF(gene name synonym)|uniprotkb:HF1(gene name synonym)|uniprotkb:HF2(gene name synonym)|uniprotkb:H factor 1(gene name synonym)	psi-mi:sdre_staam(display_long)|uniprotkb:sdrE(gene name)|psi-mi:sdrE(display_short)|uniprotkb:SAV0563(locus name)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Zhang et al. (2017)	pubmed:28258151|imex:IM-28434	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:158878(staam)|taxid:158878("Staphylococcus aureus (strain Mu50 / ATCC 700699)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-26369518|imex:IM-28434-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000177.2|dip:DIP-38303N|ensembl:ENSG00000000971(gene)|ensembl:ENST00000367429(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006956"(complement activation)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0008201"(heparin binding)|go:"GO:0030449"(regulation of complement activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:1903659"(regulation of complement-dependent cytotoxicity)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|mint:P08603|rcsb pdb:1FHC|rcsb pdb:1HAQ|rcsb pdb:1HCC|rcsb pdb:1HFH|rcsb pdb:1HFI|rcsb pdb:1KOV|rcsb pdb:2QFH|rcsb pdb:2RLP|rcsb pdb:2RLQ|rcsb pdb:2UWN|rcsb pdb:2V8E|rcsb pdb:2W80|rcsb pdb:2BZM|rcsb pdb:2G7I|rcsb pdb:2W81|rcsb pdb:2WII|rcsb pdb:2XQW|rcsb pdb:3GAU|rcsb pdb:3GAV|rcsb pdb:3GAW|rcsb pdb:3KXV|rcsb pdb:3KZJ|rcsb pdb:3OXU|rcsb pdb:3R62|rcsb pdb:3RJ3|rcsb pdb:3SW0|rcsb pdb:4AYD|rcsb pdb:4AYE|rcsb pdb:4AYI|rcsb pdb:4AYM|rcsb pdb:4B2R|rcsb pdb:4B2S|rcsb pdb:2IC4|rcsb pdb:2JGW|rcsb pdb:2JGX|rcsb pdb:4J38|rcsb pdb:4K12|rcsb pdb:4ONT|rcsb pdb:4ZH1|rcsb pdb:5NBQ|rcsb pdb:5O32|rcsb pdb:5O35|rcsb pdb:2KMS|rcsb pdb:2QFG|rcsb pdb:5WTB|rcsb pdb:6ATG|reactome:R-HSA-977606	ensemblbacteria:BAB56725(transcript)|ensemblbacteria:SAV0563(gene)|go:"GO:0005576"(extracellular region)|go:"GO:0005618"(cell wall)|go:"GO:0007155"(cell adhesion)|refseq:WP_000610237.1|rcsb pdb:5WTA|rcsb pdb:5WTB|interpro:IPR011266(Fibrogen-binding, domain 2)|interpro:IPR008966(Adhesion, bacterial)|interpro:IPR011252(Fibrogen-binding, domain 1)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR019931|interpro:IPR033764|interpro:IPR041171|interpro:IPR005877(YSIRK Gram-positive signal peptide)	-	-	-	figure legend:F1E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:0.4x10^-6(molar)	2020/10/16	2020/10/16	rogid:1mjo+AJLIQnEsMFqsGsmUFbfUxk9606	rogid:7whrWG4mQYp7Cw6oDDq01h3nOdw158878	rigid:b9mvI93Z8/0tpq6x2HDfRA2OE5c	false	sufficient binding region:1206-1226|glutathione s tranferase tag:n-n	binding-associated region:270-599|his tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P08603	uniprotkb:Q932F7	intact:EBI-1223708|uniprotkb:A5PL14|uniprotkb:Q2TAZ5|uniprotkb:P78435|uniprotkb:Q14570|uniprotkb:Q38G77|uniprotkb:Q5TFM3|uniprotkb:Q8N708|uniprotkb:Q9NU86|ensembl:ENSP00000356399	intact:EBI-26369465|ensemblbacteria:BAB56725	psi-mi:cfah_human(display_long)|uniprotkb:CFH(gene name)|psi-mi:CFH(display_short)|uniprotkb:HF(gene name synonym)|uniprotkb:HF1(gene name synonym)|uniprotkb:HF2(gene name synonym)|uniprotkb:H factor 1(gene name synonym)	psi-mi:sdre_staam(display_long)|uniprotkb:sdrE(gene name)|psi-mi:sdrE(display_short)|uniprotkb:SAV0563(locus name)	psi-mi:"MI:0096"(pull down)	Zhang et al. (2017)	pubmed:28258151|imex:IM-28434	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:158878(staam)|taxid:158878("Staphylococcus aureus (strain Mu50 / ATCC 700699)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-26369498|imex:IM-28434-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000177.2|dip:DIP-38303N|ensembl:ENSG00000000971(gene)|ensembl:ENST00000367429(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006956"(complement activation)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0008201"(heparin binding)|go:"GO:0030449"(regulation of complement activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:1903659"(regulation of complement-dependent cytotoxicity)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|mint:P08603|rcsb pdb:1FHC|rcsb pdb:1HAQ|rcsb pdb:1HCC|rcsb pdb:1HFH|rcsb pdb:1HFI|rcsb pdb:1KOV|rcsb pdb:2QFH|rcsb pdb:2RLP|rcsb pdb:2RLQ|rcsb pdb:2UWN|rcsb pdb:2V8E|rcsb pdb:2W80|rcsb pdb:2BZM|rcsb pdb:2G7I|rcsb pdb:2W81|rcsb pdb:2WII|rcsb pdb:2XQW|rcsb pdb:3GAU|rcsb pdb:3GAV|rcsb pdb:3GAW|rcsb pdb:3KXV|rcsb pdb:3KZJ|rcsb pdb:3OXU|rcsb pdb:3R62|rcsb pdb:3RJ3|rcsb pdb:3SW0|rcsb pdb:4AYD|rcsb pdb:4AYE|rcsb pdb:4AYI|rcsb pdb:4AYM|rcsb pdb:4B2R|rcsb pdb:4B2S|rcsb pdb:2IC4|rcsb pdb:2JGW|rcsb pdb:2JGX|rcsb pdb:4J38|rcsb pdb:4K12|rcsb pdb:4ONT|rcsb pdb:4ZH1|rcsb pdb:5NBQ|rcsb pdb:5O32|rcsb pdb:5O35|rcsb pdb:2KMS|rcsb pdb:2QFG|rcsb pdb:5WTB|rcsb pdb:6ATG|reactome:R-HSA-977606	ensemblbacteria:BAB56725(transcript)|ensemblbacteria:SAV0563(gene)|go:"GO:0005576"(extracellular region)|go:"GO:0005618"(cell wall)|go:"GO:0007155"(cell adhesion)|refseq:WP_000610237.1|rcsb pdb:5WTA|rcsb pdb:5WTB|interpro:IPR011266(Fibrogen-binding, domain 2)|interpro:IPR008966(Adhesion, bacterial)|interpro:IPR011252(Fibrogen-binding, domain 1)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR019931|interpro:IPR033764|interpro:IPR041171|interpro:IPR005877(YSIRK Gram-positive signal peptide)	-	-	-	figure legend:F1B F1C F1D F3B F3C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/10/16	2020/10/16	rogid:1mjo+AJLIQnEsMFqsGsmUFbfUxk9606	rogid:7whrWG4mQYp7Cw6oDDq01h3nOdw158878	rigid:b9mvI93Z8/0tpq6x2HDfRA2OE5c	false	mutation disrupting interaction:1208-1208|mutation increasing interaction:1210-1210|mutation decreasing interaction:1211-1211|mutation increasing interaction:1212-1212|mutation increasing interaction:1213-1213|mutation increasing interaction:1214-1214|mutation with no effect:1215-1215|mutation increasing interaction:1216-1216|mutation with no effect:1217-1217|mutation disrupting interaction:1206-1206|mutation decreasing interaction:1207-1207|mutation increasing interaction:1218-1218|mutation with no effect:1219-1219|mutation with no effect:1220-1220|mutation with no effect:1222-1222|mutation increasing interaction:1223-1223|mutation increasing interaction:1224-1224|mutation increasing interaction:1225-1225|mutation decreasing interaction:1226-1226|mutation decreasing interaction:1209-1209|sufficient binding region:1206-1226|glutathione s tranferase tag:n-n	mutation decreasing interaction:334-334|mutation decreasing interaction:335-335|mutation decreasing interaction:419-419|mutation disrupting interaction:588-588|binding-associated region:270-599	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P08603	uniprotkb:Q932F7	intact:EBI-1223708|uniprotkb:A5PL14|uniprotkb:Q2TAZ5|uniprotkb:P78435|uniprotkb:Q14570|uniprotkb:Q38G77|uniprotkb:Q5TFM3|uniprotkb:Q8N708|uniprotkb:Q9NU86|ensembl:ENSP00000356399	intact:EBI-26369465|ensemblbacteria:BAB56725	psi-mi:cfah_human(display_long)|uniprotkb:CFH(gene name)|psi-mi:CFH(display_short)|uniprotkb:HF(gene name synonym)|uniprotkb:HF1(gene name synonym)|uniprotkb:HF2(gene name synonym)|uniprotkb:H factor 1(gene name synonym)	psi-mi:sdre_staam(display_long)|uniprotkb:sdrE(gene name)|psi-mi:sdrE(display_short)|uniprotkb:SAV0563(locus name)	psi-mi:"MI:0071"(molecular sieving)	Zhang et al. (2017)	pubmed:28258151|imex:IM-28434	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:158878(staam)|taxid:158878("Staphylococcus aureus (strain Mu50 / ATCC 700699)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-26369649|imex:IM-28434-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000177.2|dip:DIP-38303N|ensembl:ENSG00000000971(gene)|ensembl:ENST00000367429(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006956"(complement activation)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0008201"(heparin binding)|go:"GO:0030449"(regulation of complement activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:1903659"(regulation of complement-dependent cytotoxicity)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|mint:P08603|rcsb pdb:1FHC|rcsb pdb:1HAQ|rcsb pdb:1HCC|rcsb pdb:1HFH|rcsb pdb:1HFI|rcsb pdb:1KOV|rcsb pdb:2QFH|rcsb pdb:2RLP|rcsb pdb:2RLQ|rcsb pdb:2UWN|rcsb pdb:2V8E|rcsb pdb:2W80|rcsb pdb:2BZM|rcsb pdb:2G7I|rcsb pdb:2W81|rcsb pdb:2WII|rcsb pdb:2XQW|rcsb pdb:3GAU|rcsb pdb:3GAV|rcsb pdb:3GAW|rcsb pdb:3KXV|rcsb pdb:3KZJ|rcsb pdb:3OXU|rcsb pdb:3R62|rcsb pdb:3RJ3|rcsb pdb:3SW0|rcsb pdb:4AYD|rcsb pdb:4AYE|rcsb pdb:4AYI|rcsb pdb:4AYM|rcsb pdb:4B2R|rcsb pdb:4B2S|rcsb pdb:2IC4|rcsb pdb:2JGW|rcsb pdb:2JGX|rcsb pdb:4J38|rcsb pdb:4K12|rcsb pdb:4ONT|rcsb pdb:4ZH1|rcsb pdb:5NBQ|rcsb pdb:5O32|rcsb pdb:5O35|rcsb pdb:2KMS|rcsb pdb:2QFG|rcsb pdb:5WTB|rcsb pdb:6ATG|reactome:R-HSA-977606	ensemblbacteria:BAB56725(transcript)|ensemblbacteria:SAV0563(gene)|go:"GO:0005576"(extracellular region)|go:"GO:0005618"(cell wall)|go:"GO:0007155"(cell adhesion)|refseq:WP_000610237.1|rcsb pdb:5WTA|rcsb pdb:5WTB|interpro:IPR011266(Fibrogen-binding, domain 2)|interpro:IPR008966(Adhesion, bacterial)|interpro:IPR011252(Fibrogen-binding, domain 1)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR019931|interpro:IPR033764|interpro:IPR041171|interpro:IPR005877(YSIRK Gram-positive signal peptide)	-	-	-	figure legend:SF2B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/10/16	2020/12/03	rogid:1mjo+AJLIQnEsMFqsGsmUFbfUxk9606	rogid:7whrWG4mQYp7Cw6oDDq01h3nOdw158878	rigid:b9mvI93Z8/0tpq6x2HDfRA2OE5c	false	binding-associated region:1206-1226	binding-associated region:270-599	2	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)