#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P0C6U8	uniprotkb:P0C6U8	intact:EBI-15810860|uniprotkb:P59641	intact:EBI-15810860|uniprotkb:P59641	psi-mi:r1a_sars(display_long)|uniprotkb:ORF1a polyprotein(gene name synonym)|uniprotkb:1a(orf name)	psi-mi:r1a_sars(display_long)|uniprotkb:ORF1a polyprotein(gene name synonym)|uniprotkb:1a(orf name)	psi-mi:"MI:0114"(x-ray crystallography)	Muramatsu et al. (2016)	pubmed:27799534|imex:IM-27932	taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus)	taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25567515|imex:IM-27932-1|pdbe:5B6O	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019079"(viral genome replication)|go:"GO:0019082"(viral protein processing)|go:"GO:0019083"(viral transcription)|go:"GO:0019785"(ISG15-specific protease activity)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039501"(suppression by virus of host type I interferon production)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039519"(modulation by virus of host autophagy)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039547"(suppression by virus of host TRAF activity)|go:"GO:0039548"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity)|go:"GO:0039579"(suppression by virus of host ISG15-protein conjugation)|go:"GO:0039595"(induction by virus of catabolism of host mRNA)|go:"GO:0039644"(suppression by virus of host NF-kappaB cascade)|go:"GO:0039648"(modulation by virus of host protein ubiquitination)|go:"GO:0039690"(positive stranded viral RNA replication)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039714"(cytoplasmic viral factory)|go:"GO:0039722"(suppression by virus of host toll-like receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0062243"(double membrane vesicle viral factory outer membrane)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|interpro:IPR002589(Appr-1-p processing)|interpro:IPR008740(Peptidase C30, Coronavirus endopeptidase)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR013016(Peptidase C30/C16)|interpro:IPR014822(Nsp9 replicase)|interpro:IPR014828(Nsp7 replicase)|interpro:IPR014829(Nsp8 replicase)|interpro:IPR018995|interpro:IPR021590|interpro:IPR022733|interpro:IPR024358|interpro:IPR024375|interpro:IPR032505|interpro:IPR032592|interpro:IPR036333|interpro:IPR036499|interpro:IPR037204|interpro:IPR037230|interpro:IPR038030|interpro:IPR038083|interpro:IPR038123|interpro:IPR038166|interpro:IPR038400|interpro:IPR042570|interpro:IPR043177|interpro:IPR043178|interpro:IPR043472|interpro:IPR043477|interpro:IPR043478|interpro:IPR043503|interpro:IPR043504|interpro:IPR043610|interpro:IPR043611|interpro:IPR043612|interpro:IPR043613|interpro:IPR043615|interpro:IPR044353|interpro:IPR044357|interpro:IPR044367|interpro:IPR044371|interpro:IPR044374|interpro:IPR044389|rcsb pdb:1P76|rcsb pdb:1P9T|rcsb pdb:1PA5|rcsb pdb:1PUK|go:"GO:0039604"(suppression by virus of host translation)|rcsb pdb:1Q1X|rcsb pdb:1Q2W|rcsb pdb:1QZ8|rcsb pdb:1UJ1|rcsb pdb:1UK3|rcsb pdb:1UK4|rcsb pdb:1UW7|rcsb pdb:1WOF|rcsb pdb:1YSY|rcsb pdb:1Z1I|rcsb pdb:1Z1J|rcsb pdb:2A5A|rcsb pdb:2A5I|rcsb pdb:2A5K|rcsb pdb:2ACF|rcsb pdb:2AHM|rcsb pdb:2AJ5|rcsb pdb:2ALV|rcsb pdb:2AMD|rcsb pdb:2AMQ|rcsb pdb:2BX3|rcsb pdb:2BX4|rcsb pdb:2C3S|rcsb pdb:2D2D|rcsb pdb:2DUC|rcsb pdb:2FAV|rcsb pdb:2FE8|rcsb pdb:2FYG|rcsb pdb:2G9T|rcsb pdb:2GA6|rcsb pdb:2GDT|rcsb pdb:2GRI|rcsb pdb:2GT7|rcsb pdb:2GT8|rcsb pdb:2GTB|rcsb pdb:2GX4|rcsb pdb:2GZ7|rcsb pdb:2GZ8|rcsb pdb:2GZ9|rcsb pdb:2H2Z|rcsb pdb:2HOB|rcsb pdb:2HSX|rcsb pdb:2IDY|rcsb pdb:2KAF|rcsb pdb:2KQV|rcsb pdb:2KQW|rcsb pdb:2KYS|rcsb pdb:2LIZ|rcsb pdb:2OP9|rcsb pdb:2PWX|rcsb pdb:2W2G|rcsb pdb:2WCT|rcsb pdb:2Z3C|rcsb pdb:2Z3D|rcsb pdb:2Z3E|rcsb pdb:2ZU4|rcsb pdb:2ZU5|rcsb pdb:3ATW|rcsb pdb:3AVZ|rcsb pdb:3AW0|rcsb pdb:3AW1|rcsb pdb:3E91|rcsb pdb:3EA7|rcsb pdb:3EA8|rcsb pdb:3EA9|rcsb pdb:3EAJ|rcsb pdb:3EE7|rcsb pdb:3F9E|rcsb pdb:3F9F|rcsb pdb:3F9G|rcsb pdb:3F9H|rcsb pdb:3FZD|rcsb pdb:3IWM|rcsb pdb:3M3S|rcsb pdb:3M3T|rcsb pdb:3M3V|rcsb pdb:3MJ5|rcsb pdb:3R24|rcsb pdb:3SN8|rcsb pdb:3SNA|rcsb pdb:3SNB|rcsb pdb:3SNC|rcsb pdb:3SND|rcsb pdb:3SNE|rcsb pdb:1UK2|rcsb pdb:3SZN|rcsb pdb:3TIT|rcsb pdb:3TIU|rcsb pdb:3TNS|rcsb pdb:3TNT|rcsb pdb:3V3M|rcsb pdb:3VB3|rcsb pdb:3VB4|rcsb pdb:3VB5|rcsb pdb:3VB6|rcsb pdb:3VB7|rcsb pdb:4HI3|rcsb pdb:4M0W|rcsb pdb:4MDS|rcsb pdb:4MM3|rcsb pdb:4OVZ|rcsb pdb:4OW0|rcsb pdb:5F22|rcsb pdb:5Y3E|rcsb pdb:5Y3Q|rcsb pdb:6LNY|rcsb pdb:6NUR|rcsb pdb:6NUS|rcsb pdb:6W2A|rcsb pdb:6XHL|rcsb pdb:6XHN|rcsb pdb:6XHO|rcsb pdb:6Y7M|rcsb pdb:6YXJ|rcsb pdb:6LO0|reactome:R-HSA-9679504|reactome:R-HSA-9682706|reactome:R-HSA-9682708|reactome:R-HSA-9683439|reactome:R-HSA-9684325|dip:DIP-48580N	go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019079"(viral genome replication)|go:"GO:0019082"(viral protein processing)|go:"GO:0019083"(viral transcription)|go:"GO:0019785"(ISG15-specific protease activity)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039501"(suppression by virus of host type I interferon production)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039519"(modulation by virus of host autophagy)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039547"(suppression by virus of host TRAF activity)|go:"GO:0039548"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity)|go:"GO:0039579"(suppression by virus of host ISG15-protein conjugation)|go:"GO:0039595"(induction by virus of catabolism of host mRNA)|go:"GO:0039644"(suppression by virus of host NF-kappaB cascade)|go:"GO:0039648"(modulation by virus of host protein ubiquitination)|go:"GO:0039690"(positive stranded viral RNA replication)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039714"(cytoplasmic viral factory)|go:"GO:0039722"(suppression by virus of host toll-like receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0062243"(double membrane vesicle viral factory outer membrane)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|interpro:IPR002589(Appr-1-p processing)|interpro:IPR008740(Peptidase C30, Coronavirus endopeptidase)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR013016(Peptidase C30/C16)|interpro:IPR014822(Nsp9 replicase)|interpro:IPR014828(Nsp7 replicase)|interpro:IPR014829(Nsp8 replicase)|interpro:IPR018995|interpro:IPR021590|interpro:IPR022733|interpro:IPR024358|interpro:IPR024375|interpro:IPR032505|interpro:IPR032592|interpro:IPR036333|interpro:IPR036499|interpro:IPR037204|interpro:IPR037230|interpro:IPR038030|interpro:IPR038083|interpro:IPR038123|interpro:IPR038166|interpro:IPR038400|interpro:IPR042570|interpro:IPR043177|interpro:IPR043178|interpro:IPR043472|interpro:IPR043477|interpro:IPR043478|interpro:IPR043503|interpro:IPR043504|interpro:IPR043610|interpro:IPR043611|interpro:IPR043612|interpro:IPR043613|interpro:IPR043615|interpro:IPR044353|interpro:IPR044357|interpro:IPR044367|interpro:IPR044371|interpro:IPR044374|interpro:IPR044389|rcsb pdb:1P76|rcsb pdb:1P9T|rcsb pdb:1PA5|rcsb pdb:1PUK|go:"GO:0039604"(suppression by virus of host translation)|rcsb pdb:1Q1X|rcsb pdb:1Q2W|rcsb pdb:1QZ8|rcsb pdb:1UJ1|rcsb pdb:1UK3|rcsb pdb:1UK4|rcsb pdb:1UW7|rcsb pdb:1WOF|rcsb pdb:1YSY|rcsb pdb:1Z1I|rcsb pdb:1Z1J|rcsb pdb:2A5A|rcsb pdb:2A5I|rcsb pdb:2A5K|rcsb pdb:2ACF|rcsb pdb:2AHM|rcsb pdb:2AJ5|rcsb pdb:2ALV|rcsb pdb:2AMD|rcsb pdb:2AMQ|rcsb pdb:2BX3|rcsb pdb:2BX4|rcsb pdb:2C3S|rcsb pdb:2D2D|rcsb pdb:2DUC|rcsb pdb:2FAV|rcsb pdb:2FE8|rcsb pdb:2FYG|rcsb pdb:2G9T|rcsb pdb:2GA6|rcsb pdb:2GDT|rcsb pdb:2GRI|rcsb pdb:2GT7|rcsb pdb:2GT8|rcsb pdb:2GTB|rcsb pdb:2GX4|rcsb pdb:2GZ7|rcsb pdb:2GZ8|rcsb pdb:2GZ9|rcsb pdb:2H2Z|rcsb pdb:2HOB|rcsb pdb:2HSX|rcsb pdb:2IDY|rcsb pdb:2KAF|rcsb pdb:2KQV|rcsb pdb:2KQW|rcsb pdb:2KYS|rcsb pdb:2LIZ|rcsb pdb:2OP9|rcsb pdb:2PWX|rcsb pdb:2W2G|rcsb pdb:2WCT|rcsb pdb:2Z3C|rcsb pdb:2Z3D|rcsb pdb:2Z3E|rcsb pdb:2ZU4|rcsb pdb:2ZU5|rcsb pdb:3ATW|rcsb pdb:3AVZ|rcsb pdb:3AW0|rcsb pdb:3AW1|rcsb pdb:3E91|rcsb pdb:3EA7|rcsb pdb:3EA8|rcsb pdb:3EA9|rcsb pdb:3EAJ|rcsb pdb:3EE7|rcsb pdb:3F9E|rcsb pdb:3F9F|rcsb pdb:3F9G|rcsb pdb:3F9H|rcsb pdb:3FZD|rcsb pdb:3IWM|rcsb pdb:3M3S|rcsb pdb:3M3T|rcsb pdb:3M3V|rcsb pdb:3MJ5|rcsb pdb:3R24|rcsb pdb:3SN8|rcsb pdb:3SNA|rcsb pdb:3SNB|rcsb pdb:3SNC|rcsb pdb:3SND|rcsb pdb:3SNE|rcsb pdb:1UK2|rcsb pdb:3SZN|rcsb pdb:3TIT|rcsb pdb:3TIU|rcsb pdb:3TNS|rcsb pdb:3TNT|rcsb pdb:3V3M|rcsb pdb:3VB3|rcsb pdb:3VB4|rcsb pdb:3VB5|rcsb pdb:3VB6|rcsb pdb:3VB7|rcsb pdb:4HI3|rcsb pdb:4M0W|rcsb pdb:4MDS|rcsb pdb:4MM3|rcsb pdb:4OVZ|rcsb pdb:4OW0|rcsb pdb:5F22|rcsb pdb:5Y3E|rcsb pdb:5Y3Q|rcsb pdb:6LNY|rcsb pdb:6NUR|rcsb pdb:6NUS|rcsb pdb:6W2A|rcsb pdb:6XHL|rcsb pdb:6XHN|rcsb pdb:6XHO|rcsb pdb:6Y7M|rcsb pdb:6YXJ|rcsb pdb:6LO0|reactome:R-HSA-9679504|reactome:R-HSA-9682706|reactome:R-HSA-9682708|reactome:R-HSA-9683439|reactome:R-HSA-9684325|dip:DIP-48580N	-	-	-	figure legend:Fig. 1a-c, S1a, Table S1|3d-resolution:2.2Å|3d-r-factors:"Rwork: 0.206  Rfree: 0.254"|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/04/21	2020/04/21	rogid:zwPSRRjRlqC4IBqawJVQzY4HMGs694009	rogid:zwPSRRjRlqC4IBqawJVQzY4HMGs694009	rigid:TuTWzCx9YxuT5l50AKaKfhQhxaw	false	sufficient binding region:3241-3556|mutation:3385-3385	sufficient binding region:3241-3556|mutation:3385-3385	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0C6U8-PRO_0000338259	uniprotkb:P0C6U8-PRO_0000338259	intact:EBI-25496008	intact:EBI-25496008	psi-mi:p0c6u8-pro_0000338259(display_long)|uniprotkb:ORF1a polyprotein(gene name synonym)|uniprotkb:1a(orf name)	psi-mi:p0c6u8-pro_0000338259(display_long)|uniprotkb:ORF1a polyprotein(gene name synonym)|uniprotkb:1a(orf name)	psi-mi:"MI:0114"(x-ray crystallography)	Muramatsu et al. (2016)	pubmed:27799534|imex:IM-27932	taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus)	taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25567582|imex:IM-27932-3|pdbe:2DUC	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-15810860(chain-parent)	intact:EBI-15810860(chain-parent)	-	chain-seq-start:3241|chain-seq-end:3546	chain-seq-start:3241|chain-seq-end:3546	figure legend:Table S1, Figures 1, S1a|3d-resolution:1.7Å|3d-r-factors:"Rwork: 0.194  Rfree: 0.221"|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/04/21	2020/04/23	rogid:6LbRC/jITHtqNPZLpKst/+pNdOQ694009	rogid:6LbRC/jITHtqNPZLpKst/+pNdOQ694009	rigid:oE/7cURQPcwCKosVpVBZnUBkgKI	false	-	-	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-25569810	uniprotkb:P0C6U8	-	intact:EBI-15810860|uniprotkb:P59641	psi-mi:nma-tsavlqsgfrk-dnp-nh2(display_short)|psi-mi:EBI-25569810(display_long)	psi-mi:r1a_sars(display_long)|uniprotkb:ORF1a polyprotein(gene name synonym)|uniprotkb:1a(orf name)	psi-mi:"MI:0435"(protease assay)	Muramatsu et al. (2016)	pubmed:27799534|imex:IM-27932	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25567661|imex:IM-27932-5	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0327"(peptide)	psi-mi:"MI:0326"(protein)	-	go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019079"(viral genome replication)|go:"GO:0019082"(viral protein processing)|go:"GO:0019083"(viral transcription)|go:"GO:0019785"(ISG15-specific protease activity)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039501"(suppression by virus of host type I interferon production)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039519"(modulation by virus of host autophagy)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039547"(suppression by virus of host TRAF activity)|go:"GO:0039548"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity)|go:"GO:0039579"(suppression by virus of host ISG15-protein conjugation)|go:"GO:0039595"(induction by virus of catabolism of host mRNA)|go:"GO:0039644"(suppression by virus of host NF-kappaB cascade)|go:"GO:0039648"(modulation by virus of host protein ubiquitination)|go:"GO:0039690"(positive stranded viral RNA replication)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039714"(cytoplasmic viral factory)|go:"GO:0039722"(suppression by virus of host toll-like receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0062243"(double membrane vesicle viral factory outer membrane)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|interpro:IPR002589(Appr-1-p processing)|interpro:IPR008740(Peptidase C30, Coronavirus endopeptidase)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR013016(Peptidase C30/C16)|interpro:IPR014822(Nsp9 replicase)|interpro:IPR014828(Nsp7 replicase)|interpro:IPR014829(Nsp8 replicase)|interpro:IPR018995|interpro:IPR021590|interpro:IPR022733|interpro:IPR024358|interpro:IPR024375|interpro:IPR032505|interpro:IPR032592|interpro:IPR036333|interpro:IPR036499|interpro:IPR037204|interpro:IPR037230|interpro:IPR038030|interpro:IPR038083|interpro:IPR038123|interpro:IPR038166|interpro:IPR038400|interpro:IPR042570|interpro:IPR043177|interpro:IPR043178|interpro:IPR043472|interpro:IPR043477|interpro:IPR043478|interpro:IPR043503|interpro:IPR043504|interpro:IPR043610|interpro:IPR043611|interpro:IPR043612|interpro:IPR043613|interpro:IPR043615|interpro:IPR044353|interpro:IPR044357|interpro:IPR044367|interpro:IPR044371|interpro:IPR044374|interpro:IPR044389|rcsb pdb:1P76|rcsb pdb:1P9T|rcsb pdb:1PA5|rcsb pdb:1PUK|go:"GO:0039604"(suppression by virus of host translation)|rcsb pdb:1Q1X|rcsb pdb:1Q2W|rcsb pdb:1QZ8|rcsb pdb:1UJ1|rcsb pdb:1UK3|rcsb pdb:1UK4|rcsb pdb:1UW7|rcsb pdb:1WOF|rcsb pdb:1YSY|rcsb pdb:1Z1I|rcsb pdb:1Z1J|rcsb pdb:2A5A|rcsb pdb:2A5I|rcsb pdb:2A5K|rcsb pdb:2ACF|rcsb pdb:2AHM|rcsb pdb:2AJ5|rcsb pdb:2ALV|rcsb pdb:2AMD|rcsb pdb:2AMQ|rcsb pdb:2BX3|rcsb pdb:2BX4|rcsb pdb:2C3S|rcsb pdb:2D2D|rcsb pdb:2DUC|rcsb pdb:2FAV|rcsb pdb:2FE8|rcsb pdb:2FYG|rcsb pdb:2G9T|rcsb pdb:2GA6|rcsb pdb:2GDT|rcsb pdb:2GRI|rcsb pdb:2GT7|rcsb pdb:2GT8|rcsb pdb:2GTB|rcsb pdb:2GX4|rcsb pdb:2GZ7|rcsb pdb:2GZ8|rcsb pdb:2GZ9|rcsb pdb:2H2Z|rcsb pdb:2HOB|rcsb pdb:2HSX|rcsb pdb:2IDY|rcsb pdb:2KAF|rcsb pdb:2KQV|rcsb pdb:2KQW|rcsb pdb:2KYS|rcsb pdb:2LIZ|rcsb pdb:2OP9|rcsb pdb:2PWX|rcsb pdb:2W2G|rcsb pdb:2WCT|rcsb pdb:2Z3C|rcsb pdb:2Z3D|rcsb pdb:2Z3E|rcsb pdb:2ZU4|rcsb pdb:2ZU5|rcsb pdb:3ATW|rcsb pdb:3AVZ|rcsb pdb:3AW0|rcsb pdb:3AW1|rcsb pdb:3E91|rcsb pdb:3EA7|rcsb pdb:3EA8|rcsb pdb:3EA9|rcsb pdb:3EAJ|rcsb pdb:3EE7|rcsb pdb:3F9E|rcsb pdb:3F9F|rcsb pdb:3F9G|rcsb pdb:3F9H|rcsb pdb:3FZD|rcsb pdb:3IWM|rcsb pdb:3M3S|rcsb pdb:3M3T|rcsb pdb:3M3V|rcsb pdb:3MJ5|rcsb pdb:3R24|rcsb pdb:3SN8|rcsb pdb:3SNA|rcsb pdb:3SNB|rcsb pdb:3SNC|rcsb pdb:3SND|rcsb pdb:3SNE|rcsb pdb:1UK2|rcsb pdb:3SZN|rcsb pdb:3TIT|rcsb pdb:3TIU|rcsb pdb:3TNS|rcsb pdb:3TNT|rcsb pdb:3V3M|rcsb pdb:3VB3|rcsb pdb:3VB4|rcsb pdb:3VB5|rcsb pdb:3VB6|rcsb pdb:3VB7|rcsb pdb:4HI3|rcsb pdb:4M0W|rcsb pdb:4MDS|rcsb pdb:4MM3|rcsb pdb:4OVZ|rcsb pdb:4OW0|rcsb pdb:5F22|rcsb pdb:5Y3E|rcsb pdb:5Y3Q|rcsb pdb:6LNY|rcsb pdb:6NUR|rcsb pdb:6NUS|rcsb pdb:6W2A|rcsb pdb:6XHL|rcsb pdb:6XHN|rcsb pdb:6XHO|rcsb pdb:6Y7M|rcsb pdb:6YXJ|rcsb pdb:6LO0|reactome:R-HSA-9679504|reactome:R-HSA-9682706|reactome:R-HSA-9682708|reactome:R-HSA-9683439|reactome:R-HSA-9684325|dip:DIP-48580N	-	-	-	figure legend:Table 2|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kcat:0.37x1^1 ~0.04(second -1)|km:39.0x10^-6 ~5.4(molar)	2020/04/21	2020/04/23	rogid:6QHzdcAJXIo62GWl+Qr3IoS0/F4-2	rogid:zwPSRRjRlqC4IBqawJVQzY4HMGs694009	rigid:T8bISqDsCGTmWM8xCjBSNPXhxkA	false	fluorophore:n-n	mutation:3385-3385|sufficient binding region:3231-3556|s tag:n-n|his tag:c-c	-	2	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
intact:EBI-25569810	uniprotkb:P0C6U8	-	intact:EBI-15810860|uniprotkb:P59641	psi-mi:nma-tsavlqsgfrk-dnp-nh2(display_short)|psi-mi:EBI-25569810(display_long)	psi-mi:r1a_sars(display_long)|uniprotkb:ORF1a polyprotein(gene name synonym)|uniprotkb:1a(orf name)	psi-mi:"MI:0435"(protease assay)	Muramatsu et al. (2016)	pubmed:27799534|imex:IM-27932	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25569816|imex:IM-27932-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0327"(peptide)	psi-mi:"MI:0326"(protein)	-	go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019079"(viral genome replication)|go:"GO:0019082"(viral protein processing)|go:"GO:0019083"(viral transcription)|go:"GO:0019785"(ISG15-specific protease activity)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039501"(suppression by virus of host type I interferon production)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039519"(modulation by virus of host autophagy)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039547"(suppression by virus of host TRAF activity)|go:"GO:0039548"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity)|go:"GO:0039579"(suppression by virus of host ISG15-protein conjugation)|go:"GO:0039595"(induction by virus of catabolism of host mRNA)|go:"GO:0039644"(suppression by virus of host NF-kappaB cascade)|go:"GO:0039648"(modulation by virus of host protein ubiquitination)|go:"GO:0039690"(positive stranded viral RNA replication)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039714"(cytoplasmic viral factory)|go:"GO:0039722"(suppression by virus of host toll-like receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0062243"(double membrane vesicle viral factory outer membrane)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|interpro:IPR002589(Appr-1-p processing)|interpro:IPR008740(Peptidase C30, Coronavirus endopeptidase)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR013016(Peptidase C30/C16)|interpro:IPR014822(Nsp9 replicase)|interpro:IPR014828(Nsp7 replicase)|interpro:IPR014829(Nsp8 replicase)|interpro:IPR018995|interpro:IPR021590|interpro:IPR022733|interpro:IPR024358|interpro:IPR024375|interpro:IPR032505|interpro:IPR032592|interpro:IPR036333|interpro:IPR036499|interpro:IPR037204|interpro:IPR037230|interpro:IPR038030|interpro:IPR038083|interpro:IPR038123|interpro:IPR038166|interpro:IPR038400|interpro:IPR042570|interpro:IPR043177|interpro:IPR043178|interpro:IPR043472|interpro:IPR043477|interpro:IPR043478|interpro:IPR043503|interpro:IPR043504|interpro:IPR043610|interpro:IPR043611|interpro:IPR043612|interpro:IPR043613|interpro:IPR043615|interpro:IPR044353|interpro:IPR044357|interpro:IPR044367|interpro:IPR044371|interpro:IPR044374|interpro:IPR044389|rcsb pdb:1P76|rcsb pdb:1P9T|rcsb pdb:1PA5|rcsb pdb:1PUK|go:"GO:0039604"(suppression by virus of host translation)|rcsb pdb:1Q1X|rcsb pdb:1Q2W|rcsb pdb:1QZ8|rcsb pdb:1UJ1|rcsb pdb:1UK3|rcsb pdb:1UK4|rcsb pdb:1UW7|rcsb pdb:1WOF|rcsb pdb:1YSY|rcsb pdb:1Z1I|rcsb pdb:1Z1J|rcsb pdb:2A5A|rcsb pdb:2A5I|rcsb pdb:2A5K|rcsb pdb:2ACF|rcsb pdb:2AHM|rcsb pdb:2AJ5|rcsb pdb:2ALV|rcsb pdb:2AMD|rcsb pdb:2AMQ|rcsb pdb:2BX3|rcsb pdb:2BX4|rcsb pdb:2C3S|rcsb pdb:2D2D|rcsb pdb:2DUC|rcsb pdb:2FAV|rcsb pdb:2FE8|rcsb pdb:2FYG|rcsb pdb:2G9T|rcsb pdb:2GA6|rcsb pdb:2GDT|rcsb pdb:2GRI|rcsb pdb:2GT7|rcsb pdb:2GT8|rcsb pdb:2GTB|rcsb pdb:2GX4|rcsb pdb:2GZ7|rcsb pdb:2GZ8|rcsb pdb:2GZ9|rcsb pdb:2H2Z|rcsb pdb:2HOB|rcsb pdb:2HSX|rcsb pdb:2IDY|rcsb pdb:2KAF|rcsb pdb:2KQV|rcsb pdb:2KQW|rcsb pdb:2KYS|rcsb pdb:2LIZ|rcsb pdb:2OP9|rcsb pdb:2PWX|rcsb pdb:2W2G|rcsb pdb:2WCT|rcsb pdb:2Z3C|rcsb pdb:2Z3D|rcsb pdb:2Z3E|rcsb pdb:2ZU4|rcsb pdb:2ZU5|rcsb pdb:3ATW|rcsb pdb:3AVZ|rcsb pdb:3AW0|rcsb pdb:3AW1|rcsb pdb:3E91|rcsb pdb:3EA7|rcsb pdb:3EA8|rcsb pdb:3EA9|rcsb pdb:3EAJ|rcsb pdb:3EE7|rcsb pdb:3F9E|rcsb pdb:3F9F|rcsb pdb:3F9G|rcsb pdb:3F9H|rcsb pdb:3FZD|rcsb pdb:3IWM|rcsb pdb:3M3S|rcsb pdb:3M3T|rcsb pdb:3M3V|rcsb pdb:3MJ5|rcsb pdb:3R24|rcsb pdb:3SN8|rcsb pdb:3SNA|rcsb pdb:3SNB|rcsb pdb:3SNC|rcsb pdb:3SND|rcsb pdb:3SNE|rcsb pdb:1UK2|rcsb pdb:3SZN|rcsb pdb:3TIT|rcsb pdb:3TIU|rcsb pdb:3TNS|rcsb pdb:3TNT|rcsb pdb:3V3M|rcsb pdb:3VB3|rcsb pdb:3VB4|rcsb pdb:3VB5|rcsb pdb:3VB6|rcsb pdb:3VB7|rcsb pdb:4HI3|rcsb pdb:4M0W|rcsb pdb:4MDS|rcsb pdb:4MM3|rcsb pdb:4OVZ|rcsb pdb:4OW0|rcsb pdb:5F22|rcsb pdb:5Y3E|rcsb pdb:5Y3Q|rcsb pdb:6LNY|rcsb pdb:6NUR|rcsb pdb:6NUS|rcsb pdb:6W2A|rcsb pdb:6XHL|rcsb pdb:6XHN|rcsb pdb:6XHO|rcsb pdb:6Y7M|rcsb pdb:6YXJ|rcsb pdb:6LO0|reactome:R-HSA-9679504|reactome:R-HSA-9682706|reactome:R-HSA-9682708|reactome:R-HSA-9683439|reactome:R-HSA-9684325|dip:DIP-48580N	-	-	-	figure legend:Table 2|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kcat:0.37x1^1 ~0.04(second -1)|km:39.0x10^-6 ~5.4(molar)|ki:126.0x10^-6 ~42.0(molar)	2020/04/21	2020/04/23	rogid:6QHzdcAJXIo62GWl+Qr3IoS0/F4-2	rogid:zwPSRRjRlqC4IBqawJVQzY4HMGs694009	rigid:DkC/avS8er5OPDmHegyOS4o9zgA	false	fluorophore:n-n	sufficient binding region:3231-3556|mutation:3385-3385|s tag:n-n|his tag:c-c	-	2	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
intact:EBI-25569810	intact:EBI-25569865	-	-	psi-mi:nma-tsavlqsgfrk-dnp-nh2(display_short)|psi-mi:EBI-25569810(display_long)	psi-mi:vtfq peptide(display_short)|psi-mi:EBI-25569865(display_long)	psi-mi:"MI:0435"(protease assay)	Muramatsu et al. (2016)	pubmed:27799534|imex:IM-27932	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25569816|imex:IM-27932-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0327"(peptide)	psi-mi:"MI:0327"(peptide)	-	-	-	-	-	figure legend:Table 2|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kcat:0.37x1^1 ~0.04(second -1)|km:39.0x10^-6 ~5.4(molar)|ki:126.0x10^-6 ~42.0(molar)	2020/04/21	2020/04/23	rogid:6QHzdcAJXIo62GWl+Qr3IoS0/F4-2	rogid:cCbbJJ5Aip/TpbOpOro9egznYa4-2	rigid:DkC/avS8er5OPDmHegyOS4o9zgA	false	fluorophore:n-n	-	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
intact:EBI-25569810	uniprotkb:P0C6U8	-	intact:EBI-15810860|uniprotkb:P59641	psi-mi:nma-tsavlqsgfrk-dnp-nh2(display_short)|psi-mi:EBI-25569810(display_long)	psi-mi:r1a_sars(display_long)|uniprotkb:ORF1a polyprotein(gene name synonym)|uniprotkb:1a(orf name)	psi-mi:"MI:0435"(protease assay)	Muramatsu et al. (2016)	pubmed:27799534|imex:IM-27932	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25569898|imex:IM-27932-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0327"(peptide)	psi-mi:"MI:0326"(protein)	-	go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019079"(viral genome replication)|go:"GO:0019082"(viral protein processing)|go:"GO:0019083"(viral transcription)|go:"GO:0019785"(ISG15-specific protease activity)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039501"(suppression by virus of host type I interferon production)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039519"(modulation by virus of host autophagy)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039547"(suppression by virus of host TRAF activity)|go:"GO:0039548"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity)|go:"GO:0039579"(suppression by virus of host ISG15-protein conjugation)|go:"GO:0039595"(induction by virus of catabolism of host mRNA)|go:"GO:0039644"(suppression by virus of host NF-kappaB cascade)|go:"GO:0039648"(modulation by virus of host protein ubiquitination)|go:"GO:0039690"(positive stranded viral RNA replication)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039714"(cytoplasmic viral factory)|go:"GO:0039722"(suppression by virus of host toll-like receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0062243"(double membrane vesicle viral factory outer membrane)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|interpro:IPR002589(Appr-1-p processing)|interpro:IPR008740(Peptidase C30, Coronavirus endopeptidase)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR013016(Peptidase C30/C16)|interpro:IPR014822(Nsp9 replicase)|interpro:IPR014828(Nsp7 replicase)|interpro:IPR014829(Nsp8 replicase)|interpro:IPR018995|interpro:IPR021590|interpro:IPR022733|interpro:IPR024358|interpro:IPR024375|interpro:IPR032505|interpro:IPR032592|interpro:IPR036333|interpro:IPR036499|interpro:IPR037204|interpro:IPR037230|interpro:IPR038030|interpro:IPR038083|interpro:IPR038123|interpro:IPR038166|interpro:IPR038400|interpro:IPR042570|interpro:IPR043177|interpro:IPR043178|interpro:IPR043472|interpro:IPR043477|interpro:IPR043478|interpro:IPR043503|interpro:IPR043504|interpro:IPR043610|interpro:IPR043611|interpro:IPR043612|interpro:IPR043613|interpro:IPR043615|interpro:IPR044353|interpro:IPR044357|interpro:IPR044367|interpro:IPR044371|interpro:IPR044374|interpro:IPR044389|rcsb pdb:1P76|rcsb pdb:1P9T|rcsb pdb:1PA5|rcsb pdb:1PUK|go:"GO:0039604"(suppression by virus of host translation)|rcsb pdb:1Q1X|rcsb pdb:1Q2W|rcsb pdb:1QZ8|rcsb pdb:1UJ1|rcsb pdb:1UK3|rcsb pdb:1UK4|rcsb pdb:1UW7|rcsb pdb:1WOF|rcsb pdb:1YSY|rcsb pdb:1Z1I|rcsb pdb:1Z1J|rcsb pdb:2A5A|rcsb pdb:2A5I|rcsb pdb:2A5K|rcsb pdb:2ACF|rcsb pdb:2AHM|rcsb pdb:2AJ5|rcsb pdb:2ALV|rcsb pdb:2AMD|rcsb pdb:2AMQ|rcsb pdb:2BX3|rcsb pdb:2BX4|rcsb pdb:2C3S|rcsb pdb:2D2D|rcsb pdb:2DUC|rcsb pdb:2FAV|rcsb pdb:2FE8|rcsb pdb:2FYG|rcsb pdb:2G9T|rcsb pdb:2GA6|rcsb pdb:2GDT|rcsb pdb:2GRI|rcsb pdb:2GT7|rcsb pdb:2GT8|rcsb pdb:2GTB|rcsb pdb:2GX4|rcsb pdb:2GZ7|rcsb pdb:2GZ8|rcsb pdb:2GZ9|rcsb pdb:2H2Z|rcsb pdb:2HOB|rcsb pdb:2HSX|rcsb pdb:2IDY|rcsb pdb:2KAF|rcsb pdb:2KQV|rcsb pdb:2KQW|rcsb pdb:2KYS|rcsb pdb:2LIZ|rcsb pdb:2OP9|rcsb pdb:2PWX|rcsb pdb:2W2G|rcsb pdb:2WCT|rcsb pdb:2Z3C|rcsb pdb:2Z3D|rcsb pdb:2Z3E|rcsb pdb:2ZU4|rcsb pdb:2ZU5|rcsb pdb:3ATW|rcsb pdb:3AVZ|rcsb pdb:3AW0|rcsb pdb:3AW1|rcsb pdb:3E91|rcsb pdb:3EA7|rcsb pdb:3EA8|rcsb pdb:3EA9|rcsb pdb:3EAJ|rcsb pdb:3EE7|rcsb pdb:3F9E|rcsb pdb:3F9F|rcsb pdb:3F9G|rcsb pdb:3F9H|rcsb pdb:3FZD|rcsb pdb:3IWM|rcsb pdb:3M3S|rcsb pdb:3M3T|rcsb pdb:3M3V|rcsb pdb:3MJ5|rcsb pdb:3R24|rcsb pdb:3SN8|rcsb pdb:3SNA|rcsb pdb:3SNB|rcsb pdb:3SNC|rcsb pdb:3SND|rcsb pdb:3SNE|rcsb pdb:1UK2|rcsb pdb:3SZN|rcsb pdb:3TIT|rcsb pdb:3TIU|rcsb pdb:3TNS|rcsb pdb:3TNT|rcsb pdb:3V3M|rcsb pdb:3VB3|rcsb pdb:3VB4|rcsb pdb:3VB5|rcsb pdb:3VB6|rcsb pdb:3VB7|rcsb pdb:4HI3|rcsb pdb:4M0W|rcsb pdb:4MDS|rcsb pdb:4MM3|rcsb pdb:4OVZ|rcsb pdb:4OW0|rcsb pdb:5F22|rcsb pdb:5Y3E|rcsb pdb:5Y3Q|rcsb pdb:6LNY|rcsb pdb:6NUR|rcsb pdb:6NUS|rcsb pdb:6W2A|rcsb pdb:6XHL|rcsb pdb:6XHN|rcsb pdb:6XHO|rcsb pdb:6Y7M|rcsb pdb:6YXJ|rcsb pdb:6LO0|reactome:R-HSA-9679504|reactome:R-HSA-9682706|reactome:R-HSA-9682708|reactome:R-HSA-9683439|reactome:R-HSA-9684325|dip:DIP-48580N	-	-	-	figure legend:Table 2|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kcat:0.37x1^1 ~0.04(second -1)|km:39.0x10^-6 ~5.4(molar)|ki:11.5x10^-6 ~6.0(molar)	2020/04/21	2020/04/23	rogid:6QHzdcAJXIo62GWl+Qr3IoS0/F4-2	rogid:zwPSRRjRlqC4IBqawJVQzY4HMGs694009	rigid:fX4UdYEVK48r8j/6/sSdkBZA1G8	false	fluorophore:n-n	mutation:3385-3385|sufficient binding region:3231-3556|s tag:n-n|his tag:c-c	-	2	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
intact:EBI-25569810	intact:EBI-25569868	-	-	psi-mi:nma-tsavlqsgfrk-dnp-nh2(display_short)|psi-mi:EBI-25569810(display_long)	psi-mi:vtlq peptide(display_short)|psi-mi:EBI-25569868(display_long)	psi-mi:"MI:0435"(protease assay)	Muramatsu et al. (2016)	pubmed:27799534|imex:IM-27932	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25569898|imex:IM-27932-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0327"(peptide)	psi-mi:"MI:0327"(peptide)	-	-	-	-	-	figure legend:Table 2|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kcat:0.37x1^1 ~0.04(second -1)|km:39.0x10^-6 ~5.4(molar)|ki:11.5x10^-6 ~6.0(molar)	2020/04/21	2020/04/23	rogid:6QHzdcAJXIo62GWl+Qr3IoS0/F4-2	rogid:AQ7ZCMnSJfg2qDPx91rYVzuQe0s-2	rigid:fX4UdYEVK48r8j/6/sSdkBZA1G8	false	fluorophore:n-n	-	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
intact:EBI-25569810	uniprotkb:P0C6U8	-	intact:EBI-15810860|uniprotkb:P59641	psi-mi:nma-tsavlqsgfrk-dnp-nh2(display_short)|psi-mi:EBI-25569810(display_long)	psi-mi:r1a_sars(display_long)|uniprotkb:ORF1a polyprotein(gene name synonym)|uniprotkb:1a(orf name)	psi-mi:"MI:0435"(protease assay)	Muramatsu et al. (2016)	pubmed:27799534|imex:IM-27932	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25569920|imex:IM-27932-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0327"(peptide)	psi-mi:"MI:0326"(protein)	-	go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019079"(viral genome replication)|go:"GO:0019082"(viral protein processing)|go:"GO:0019083"(viral transcription)|go:"GO:0019785"(ISG15-specific protease activity)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039501"(suppression by virus of host type I interferon production)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039519"(modulation by virus of host autophagy)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039547"(suppression by virus of host TRAF activity)|go:"GO:0039548"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity)|go:"GO:0039579"(suppression by virus of host ISG15-protein conjugation)|go:"GO:0039595"(induction by virus of catabolism of host mRNA)|go:"GO:0039644"(suppression by virus of host NF-kappaB cascade)|go:"GO:0039648"(modulation by virus of host protein ubiquitination)|go:"GO:0039690"(positive stranded viral RNA replication)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039714"(cytoplasmic viral factory)|go:"GO:0039722"(suppression by virus of host toll-like receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0062243"(double membrane vesicle viral factory outer membrane)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|interpro:IPR002589(Appr-1-p processing)|interpro:IPR008740(Peptidase C30, Coronavirus endopeptidase)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR013016(Peptidase C30/C16)|interpro:IPR014822(Nsp9 replicase)|interpro:IPR014828(Nsp7 replicase)|interpro:IPR014829(Nsp8 replicase)|interpro:IPR018995|interpro:IPR021590|interpro:IPR022733|interpro:IPR024358|interpro:IPR024375|interpro:IPR032505|interpro:IPR032592|interpro:IPR036333|interpro:IPR036499|interpro:IPR037204|interpro:IPR037230|interpro:IPR038030|interpro:IPR038083|interpro:IPR038123|interpro:IPR038166|interpro:IPR038400|interpro:IPR042570|interpro:IPR043177|interpro:IPR043178|interpro:IPR043472|interpro:IPR043477|interpro:IPR043478|interpro:IPR043503|interpro:IPR043504|interpro:IPR043610|interpro:IPR043611|interpro:IPR043612|interpro:IPR043613|interpro:IPR043615|interpro:IPR044353|interpro:IPR044357|interpro:IPR044367|interpro:IPR044371|interpro:IPR044374|interpro:IPR044389|rcsb pdb:1P76|rcsb pdb:1P9T|rcsb pdb:1PA5|rcsb pdb:1PUK|go:"GO:0039604"(suppression by virus of host translation)|rcsb pdb:1Q1X|rcsb pdb:1Q2W|rcsb pdb:1QZ8|rcsb pdb:1UJ1|rcsb pdb:1UK3|rcsb pdb:1UK4|rcsb pdb:1UW7|rcsb pdb:1WOF|rcsb pdb:1YSY|rcsb pdb:1Z1I|rcsb pdb:1Z1J|rcsb pdb:2A5A|rcsb pdb:2A5I|rcsb pdb:2A5K|rcsb pdb:2ACF|rcsb pdb:2AHM|rcsb pdb:2AJ5|rcsb pdb:2ALV|rcsb pdb:2AMD|rcsb pdb:2AMQ|rcsb pdb:2BX3|rcsb pdb:2BX4|rcsb pdb:2C3S|rcsb pdb:2D2D|rcsb pdb:2DUC|rcsb pdb:2FAV|rcsb pdb:2FE8|rcsb pdb:2FYG|rcsb pdb:2G9T|rcsb pdb:2GA6|rcsb pdb:2GDT|rcsb pdb:2GRI|rcsb pdb:2GT7|rcsb pdb:2GT8|rcsb pdb:2GTB|rcsb pdb:2GX4|rcsb pdb:2GZ7|rcsb pdb:2GZ8|rcsb pdb:2GZ9|rcsb pdb:2H2Z|rcsb pdb:2HOB|rcsb pdb:2HSX|rcsb pdb:2IDY|rcsb pdb:2KAF|rcsb pdb:2KQV|rcsb pdb:2KQW|rcsb pdb:2KYS|rcsb pdb:2LIZ|rcsb pdb:2OP9|rcsb pdb:2PWX|rcsb pdb:2W2G|rcsb pdb:2WCT|rcsb pdb:2Z3C|rcsb pdb:2Z3D|rcsb pdb:2Z3E|rcsb pdb:2ZU4|rcsb pdb:2ZU5|rcsb pdb:3ATW|rcsb pdb:3AVZ|rcsb pdb:3AW0|rcsb pdb:3AW1|rcsb pdb:3E91|rcsb pdb:3EA7|rcsb pdb:3EA8|rcsb pdb:3EA9|rcsb pdb:3EAJ|rcsb pdb:3EE7|rcsb pdb:3F9E|rcsb pdb:3F9F|rcsb pdb:3F9G|rcsb pdb:3F9H|rcsb pdb:3FZD|rcsb pdb:3IWM|rcsb pdb:3M3S|rcsb pdb:3M3T|rcsb pdb:3M3V|rcsb pdb:3MJ5|rcsb pdb:3R24|rcsb pdb:3SN8|rcsb pdb:3SNA|rcsb pdb:3SNB|rcsb pdb:3SNC|rcsb pdb:3SND|rcsb pdb:3SNE|rcsb pdb:1UK2|rcsb pdb:3SZN|rcsb pdb:3TIT|rcsb pdb:3TIU|rcsb pdb:3TNS|rcsb pdb:3TNT|rcsb pdb:3V3M|rcsb pdb:3VB3|rcsb pdb:3VB4|rcsb pdb:3VB5|rcsb pdb:3VB6|rcsb pdb:3VB7|rcsb pdb:4HI3|rcsb pdb:4M0W|rcsb pdb:4MDS|rcsb pdb:4MM3|rcsb pdb:4OVZ|rcsb pdb:4OW0|rcsb pdb:5F22|rcsb pdb:5Y3E|rcsb pdb:5Y3Q|rcsb pdb:6LNY|rcsb pdb:6NUR|rcsb pdb:6NUS|rcsb pdb:6W2A|rcsb pdb:6XHL|rcsb pdb:6XHN|rcsb pdb:6XHO|rcsb pdb:6Y7M|rcsb pdb:6YXJ|rcsb pdb:6LO0|reactome:R-HSA-9679504|reactome:R-HSA-9682706|reactome:R-HSA-9682708|reactome:R-HSA-9683439|reactome:R-HSA-9684325|dip:DIP-48580N	-	-	-	figure legend:Table 2|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ki:18.4x10^-6 ~9.3(molar)|kcat:0.37x1^1 ~0.04(second -1)|km:39.0x10^-6 ~5.4(molar)	2020/04/21	2020/04/23	rogid:6QHzdcAJXIo62GWl+Qr3IoS0/F4-2	rogid:zwPSRRjRlqC4IBqawJVQzY4HMGs694009	rigid:VEI96+mA0WNljQ7NcaXDD9E3D8A	false	fluorophore:n-n	mutation:3385-3385|sufficient binding region:3231-3556|s tag:n-n|his tag:c-c	-	2	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
intact:EBI-25569810	intact:EBI-25569871	-	-	psi-mi:nma-tsavlqsgfrk-dnp-nh2(display_short)|psi-mi:EBI-25569810(display_long)	psi-mi:vtaq peptide(display_short)|psi-mi:EBI-25569871(display_long)	psi-mi:"MI:0435"(protease assay)	Muramatsu et al. (2016)	pubmed:27799534|imex:IM-27932	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25569920|imex:IM-27932-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0327"(peptide)	psi-mi:"MI:0327"(peptide)	-	-	-	-	-	figure legend:Table 2|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ki:18.4x10^-6 ~9.3(molar)|kcat:0.37x1^1 ~0.04(second -1)|km:39.0x10^-6 ~5.4(molar)	2020/04/21	2020/04/23	rogid:6QHzdcAJXIo62GWl+Qr3IoS0/F4-2	rogid:ebnisypMjoSImg8o/VZSQXQDQ8E-2	rigid:VEI96+mA0WNljQ7NcaXDD9E3D8A	false	fluorophore:n-n	-	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:P0C6U8	uniprotkb:P0C6U8	intact:EBI-15810860|uniprotkb:P59641	intact:EBI-15810860|uniprotkb:P59641	psi-mi:r1a_sars(display_long)|uniprotkb:ORF1a polyprotein(gene name synonym)|uniprotkb:1a(orf name)	psi-mi:r1a_sars(display_long)|uniprotkb:ORF1a polyprotein(gene name synonym)|uniprotkb:1a(orf name)	psi-mi:"MI:0435"(protease assay)	Muramatsu et al. (2016)	pubmed:27799534|imex:IM-27932	taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus)	taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25590074|imex:IM-27932-12	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019079"(viral genome replication)|go:"GO:0019082"(viral protein processing)|go:"GO:0019083"(viral transcription)|go:"GO:0019785"(ISG15-specific protease activity)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039501"(suppression by virus of host type I interferon production)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039519"(modulation by virus of host autophagy)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039547"(suppression by virus of host TRAF activity)|go:"GO:0039548"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity)|go:"GO:0039579"(suppression by virus of host ISG15-protein conjugation)|go:"GO:0039595"(induction by virus of catabolism of host mRNA)|go:"GO:0039644"(suppression by virus of host NF-kappaB cascade)|go:"GO:0039648"(modulation by virus of host protein ubiquitination)|go:"GO:0039690"(positive stranded viral RNA replication)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039714"(cytoplasmic viral factory)|go:"GO:0039722"(suppression by virus of host toll-like receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0062243"(double membrane vesicle viral factory outer membrane)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|interpro:IPR002589(Appr-1-p processing)|interpro:IPR008740(Peptidase C30, Coronavirus endopeptidase)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR013016(Peptidase C30/C16)|interpro:IPR014822(Nsp9 replicase)|interpro:IPR014828(Nsp7 replicase)|interpro:IPR014829(Nsp8 replicase)|interpro:IPR018995|interpro:IPR021590|interpro:IPR022733|interpro:IPR024358|interpro:IPR024375|interpro:IPR032505|interpro:IPR032592|interpro:IPR036333|interpro:IPR036499|interpro:IPR037204|interpro:IPR037230|interpro:IPR038030|interpro:IPR038083|interpro:IPR038123|interpro:IPR038166|interpro:IPR038400|interpro:IPR042570|interpro:IPR043177|interpro:IPR043178|interpro:IPR043472|interpro:IPR043477|interpro:IPR043478|interpro:IPR043503|interpro:IPR043504|interpro:IPR043610|interpro:IPR043611|interpro:IPR043612|interpro:IPR043613|interpro:IPR043615|interpro:IPR044353|interpro:IPR044357|interpro:IPR044367|interpro:IPR044371|interpro:IPR044374|interpro:IPR044389|rcsb pdb:1P76|rcsb pdb:1P9T|rcsb pdb:1PA5|rcsb pdb:1PUK|go:"GO:0039604"(suppression by virus of host translation)|rcsb pdb:1Q1X|rcsb pdb:1Q2W|rcsb pdb:1QZ8|rcsb pdb:1UJ1|rcsb pdb:1UK3|rcsb pdb:1UK4|rcsb pdb:1UW7|rcsb pdb:1WOF|rcsb pdb:1YSY|rcsb pdb:1Z1I|rcsb pdb:1Z1J|rcsb pdb:2A5A|rcsb pdb:2A5I|rcsb pdb:2A5K|rcsb pdb:2ACF|rcsb pdb:2AHM|rcsb pdb:2AJ5|rcsb pdb:2ALV|rcsb pdb:2AMD|rcsb pdb:2AMQ|rcsb pdb:2BX3|rcsb pdb:2BX4|rcsb pdb:2C3S|rcsb pdb:2D2D|rcsb pdb:2DUC|rcsb pdb:2FAV|rcsb pdb:2FE8|rcsb pdb:2FYG|rcsb pdb:2G9T|rcsb pdb:2GA6|rcsb pdb:2GDT|rcsb pdb:2GRI|rcsb pdb:2GT7|rcsb pdb:2GT8|rcsb pdb:2GTB|rcsb pdb:2GX4|rcsb pdb:2GZ7|rcsb pdb:2GZ8|rcsb pdb:2GZ9|rcsb pdb:2H2Z|rcsb pdb:2HOB|rcsb pdb:2HSX|rcsb pdb:2IDY|rcsb pdb:2KAF|rcsb pdb:2KQV|rcsb pdb:2KQW|rcsb pdb:2KYS|rcsb pdb:2LIZ|rcsb pdb:2OP9|rcsb pdb:2PWX|rcsb pdb:2W2G|rcsb pdb:2WCT|rcsb pdb:2Z3C|rcsb pdb:2Z3D|rcsb pdb:2Z3E|rcsb pdb:2ZU4|rcsb pdb:2ZU5|rcsb pdb:3ATW|rcsb pdb:3AVZ|rcsb pdb:3AW0|rcsb pdb:3AW1|rcsb pdb:3E91|rcsb pdb:3EA7|rcsb pdb:3EA8|rcsb pdb:3EA9|rcsb pdb:3EAJ|rcsb pdb:3EE7|rcsb pdb:3F9E|rcsb pdb:3F9F|rcsb pdb:3F9G|rcsb pdb:3F9H|rcsb pdb:3FZD|rcsb pdb:3IWM|rcsb pdb:3M3S|rcsb pdb:3M3T|rcsb pdb:3M3V|rcsb pdb:3MJ5|rcsb pdb:3R24|rcsb pdb:3SN8|rcsb pdb:3SNA|rcsb pdb:3SNB|rcsb pdb:3SNC|rcsb pdb:3SND|rcsb pdb:3SNE|rcsb pdb:1UK2|rcsb pdb:3SZN|rcsb pdb:3TIT|rcsb pdb:3TIU|rcsb pdb:3TNS|rcsb pdb:3TNT|rcsb pdb:3V3M|rcsb pdb:3VB3|rcsb pdb:3VB4|rcsb pdb:3VB5|rcsb pdb:3VB6|rcsb pdb:3VB7|rcsb pdb:4HI3|rcsb pdb:4M0W|rcsb pdb:4MDS|rcsb pdb:4MM3|rcsb pdb:4OVZ|rcsb pdb:4OW0|rcsb pdb:5F22|rcsb pdb:5Y3E|rcsb pdb:5Y3Q|rcsb pdb:6LNY|rcsb pdb:6NUR|rcsb pdb:6NUS|rcsb pdb:6W2A|rcsb pdb:6XHL|rcsb pdb:6XHN|rcsb pdb:6XHO|rcsb pdb:6Y7M|rcsb pdb:6YXJ|rcsb pdb:6LO0|reactome:R-HSA-9679504|reactome:R-HSA-9682706|reactome:R-HSA-9682708|reactome:R-HSA-9683439|reactome:R-HSA-9684325|dip:DIP-48580N	go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019079"(viral genome replication)|go:"GO:0019082"(viral protein processing)|go:"GO:0019083"(viral transcription)|go:"GO:0019785"(ISG15-specific protease activity)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039501"(suppression by virus of host type I interferon production)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039519"(modulation by virus of host autophagy)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039547"(suppression by virus of host TRAF activity)|go:"GO:0039548"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity)|go:"GO:0039579"(suppression by virus of host ISG15-protein conjugation)|go:"GO:0039595"(induction by virus of catabolism of host mRNA)|go:"GO:0039644"(suppression by virus of host NF-kappaB cascade)|go:"GO:0039648"(modulation by virus of host protein ubiquitination)|go:"GO:0039690"(positive stranded viral RNA replication)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039714"(cytoplasmic viral factory)|go:"GO:0039722"(suppression by virus of host toll-like receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0062243"(double membrane vesicle viral factory outer membrane)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|interpro:IPR002589(Appr-1-p processing)|interpro:IPR008740(Peptidase C30, Coronavirus endopeptidase)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR013016(Peptidase C30/C16)|interpro:IPR014822(Nsp9 replicase)|interpro:IPR014828(Nsp7 replicase)|interpro:IPR014829(Nsp8 replicase)|interpro:IPR018995|interpro:IPR021590|interpro:IPR022733|interpro:IPR024358|interpro:IPR024375|interpro:IPR032505|interpro:IPR032592|interpro:IPR036333|interpro:IPR036499|interpro:IPR037204|interpro:IPR037230|interpro:IPR038030|interpro:IPR038083|interpro:IPR038123|interpro:IPR038166|interpro:IPR038400|interpro:IPR042570|interpro:IPR043177|interpro:IPR043178|interpro:IPR043472|interpro:IPR043477|interpro:IPR043478|interpro:IPR043503|interpro:IPR043504|interpro:IPR043610|interpro:IPR043611|interpro:IPR043612|interpro:IPR043613|interpro:IPR043615|interpro:IPR044353|interpro:IPR044357|interpro:IPR044367|interpro:IPR044371|interpro:IPR044374|interpro:IPR044389|rcsb pdb:1P76|rcsb pdb:1P9T|rcsb pdb:1PA5|rcsb pdb:1PUK|go:"GO:0039604"(suppression by virus of host translation)|rcsb pdb:1Q1X|rcsb pdb:1Q2W|rcsb pdb:1QZ8|rcsb pdb:1UJ1|rcsb pdb:1UK3|rcsb pdb:1UK4|rcsb pdb:1UW7|rcsb pdb:1WOF|rcsb pdb:1YSY|rcsb pdb:1Z1I|rcsb pdb:1Z1J|rcsb pdb:2A5A|rcsb pdb:2A5I|rcsb pdb:2A5K|rcsb pdb:2ACF|rcsb pdb:2AHM|rcsb pdb:2AJ5|rcsb pdb:2ALV|rcsb pdb:2AMD|rcsb pdb:2AMQ|rcsb pdb:2BX3|rcsb pdb:2BX4|rcsb pdb:2C3S|rcsb pdb:2D2D|rcsb pdb:2DUC|rcsb pdb:2FAV|rcsb pdb:2FE8|rcsb pdb:2FYG|rcsb pdb:2G9T|rcsb pdb:2GA6|rcsb pdb:2GDT|rcsb pdb:2GRI|rcsb pdb:2GT7|rcsb pdb:2GT8|rcsb pdb:2GTB|rcsb pdb:2GX4|rcsb pdb:2GZ7|rcsb pdb:2GZ8|rcsb pdb:2GZ9|rcsb pdb:2H2Z|rcsb pdb:2HOB|rcsb pdb:2HSX|rcsb pdb:2IDY|rcsb pdb:2KAF|rcsb pdb:2KQV|rcsb pdb:2KQW|rcsb pdb:2KYS|rcsb pdb:2LIZ|rcsb pdb:2OP9|rcsb pdb:2PWX|rcsb pdb:2W2G|rcsb pdb:2WCT|rcsb pdb:2Z3C|rcsb pdb:2Z3D|rcsb pdb:2Z3E|rcsb pdb:2ZU4|rcsb pdb:2ZU5|rcsb pdb:3ATW|rcsb pdb:3AVZ|rcsb pdb:3AW0|rcsb pdb:3AW1|rcsb pdb:3E91|rcsb pdb:3EA7|rcsb pdb:3EA8|rcsb pdb:3EA9|rcsb pdb:3EAJ|rcsb pdb:3EE7|rcsb pdb:3F9E|rcsb pdb:3F9F|rcsb pdb:3F9G|rcsb pdb:3F9H|rcsb pdb:3FZD|rcsb pdb:3IWM|rcsb pdb:3M3S|rcsb pdb:3M3T|rcsb pdb:3M3V|rcsb pdb:3MJ5|rcsb pdb:3R24|rcsb pdb:3SN8|rcsb pdb:3SNA|rcsb pdb:3SNB|rcsb pdb:3SNC|rcsb pdb:3SND|rcsb pdb:3SNE|rcsb pdb:1UK2|rcsb pdb:3SZN|rcsb pdb:3TIT|rcsb pdb:3TIU|rcsb pdb:3TNS|rcsb pdb:3TNT|rcsb pdb:3V3M|rcsb pdb:3VB3|rcsb pdb:3VB4|rcsb pdb:3VB5|rcsb pdb:3VB6|rcsb pdb:3VB7|rcsb pdb:4HI3|rcsb pdb:4M0W|rcsb pdb:4MDS|rcsb pdb:4MM3|rcsb pdb:4OVZ|rcsb pdb:4OW0|rcsb pdb:5F22|rcsb pdb:5Y3E|rcsb pdb:5Y3Q|rcsb pdb:6LNY|rcsb pdb:6NUR|rcsb pdb:6NUS|rcsb pdb:6W2A|rcsb pdb:6XHL|rcsb pdb:6XHN|rcsb pdb:6XHO|rcsb pdb:6Y7M|rcsb pdb:6YXJ|rcsb pdb:6LO0|reactome:R-HSA-9679504|reactome:R-HSA-9682706|reactome:R-HSA-9682708|reactome:R-HSA-9683439|reactome:R-HSA-9684325|dip:DIP-48580N	-	-	-	figure legend:Figs. 2a-e, S4-3|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/04/21	2020/05/18	rogid:zwPSRRjRlqC4IBqawJVQzY4HMGs694009	rogid:zwPSRRjRlqC4IBqawJVQzY4HMGs694009	rigid:HMwPu9Xqpte8SlLRFljXrZoq5BQ	false	green fluorescent protein tag:?-?|sufficient binding region:3527-3556,3231-3250|s tag:n-n|his tag:c-c|mutation:3549-3549|mutation:3549-3549|mutation:3243-3243|mutation:3243-3243	sufficient binding region:3241-3556|mutation decreasing interaction rate:3546-3546|his tag:c-c	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:P0C6U8	uniprotkb:P0C6U8	intact:EBI-15810860|uniprotkb:P59641	intact:EBI-15810860|uniprotkb:P59641	psi-mi:r1a_sars(display_long)|uniprotkb:ORF1a polyprotein(gene name synonym)|uniprotkb:1a(orf name)	psi-mi:r1a_sars(display_long)|uniprotkb:ORF1a polyprotein(gene name synonym)|uniprotkb:1a(orf name)	psi-mi:"MI:0435"(protease assay)	Muramatsu et al. (2016)	pubmed:27799534|imex:IM-27932	taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus)	taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25590212|imex:IM-27932-14	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019079"(viral genome replication)|go:"GO:0019082"(viral protein processing)|go:"GO:0019083"(viral transcription)|go:"GO:0019785"(ISG15-specific protease activity)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039501"(suppression by virus of host type I interferon production)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039519"(modulation by virus of host autophagy)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039547"(suppression by virus of host TRAF activity)|go:"GO:0039548"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity)|go:"GO:0039579"(suppression by virus of host ISG15-protein conjugation)|go:"GO:0039595"(induction by virus of catabolism of host mRNA)|go:"GO:0039644"(suppression by virus of host NF-kappaB cascade)|go:"GO:0039648"(modulation by virus of host protein ubiquitination)|go:"GO:0039690"(positive stranded viral RNA replication)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039714"(cytoplasmic viral factory)|go:"GO:0039722"(suppression by virus of host toll-like receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0062243"(double membrane vesicle viral factory outer membrane)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|interpro:IPR002589(Appr-1-p processing)|interpro:IPR008740(Peptidase C30, Coronavirus endopeptidase)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR013016(Peptidase C30/C16)|interpro:IPR014822(Nsp9 replicase)|interpro:IPR014828(Nsp7 replicase)|interpro:IPR014829(Nsp8 replicase)|interpro:IPR018995|interpro:IPR021590|interpro:IPR022733|interpro:IPR024358|interpro:IPR024375|interpro:IPR032505|interpro:IPR032592|interpro:IPR036333|interpro:IPR036499|interpro:IPR037204|interpro:IPR037230|interpro:IPR038030|interpro:IPR038083|interpro:IPR038123|interpro:IPR038166|interpro:IPR038400|interpro:IPR042570|interpro:IPR043177|interpro:IPR043178|interpro:IPR043472|interpro:IPR043477|interpro:IPR043478|interpro:IPR043503|interpro:IPR043504|interpro:IPR043610|interpro:IPR043611|interpro:IPR043612|interpro:IPR043613|interpro:IPR043615|interpro:IPR044353|interpro:IPR044357|interpro:IPR044367|interpro:IPR044371|interpro:IPR044374|interpro:IPR044389|rcsb pdb:1P76|rcsb pdb:1P9T|rcsb pdb:1PA5|rcsb pdb:1PUK|go:"GO:0039604"(suppression by virus of host translation)|rcsb pdb:1Q1X|rcsb pdb:1Q2W|rcsb pdb:1QZ8|rcsb pdb:1UJ1|rcsb pdb:1UK3|rcsb pdb:1UK4|rcsb pdb:1UW7|rcsb pdb:1WOF|rcsb pdb:1YSY|rcsb pdb:1Z1I|rcsb pdb:1Z1J|rcsb pdb:2A5A|rcsb pdb:2A5I|rcsb pdb:2A5K|rcsb pdb:2ACF|rcsb pdb:2AHM|rcsb pdb:2AJ5|rcsb pdb:2ALV|rcsb pdb:2AMD|rcsb pdb:2AMQ|rcsb pdb:2BX3|rcsb pdb:2BX4|rcsb pdb:2C3S|rcsb pdb:2D2D|rcsb pdb:2DUC|rcsb pdb:2FAV|rcsb pdb:2FE8|rcsb pdb:2FYG|rcsb pdb:2G9T|rcsb pdb:2GA6|rcsb pdb:2GDT|rcsb pdb:2GRI|rcsb pdb:2GT7|rcsb pdb:2GT8|rcsb pdb:2GTB|rcsb pdb:2GX4|rcsb pdb:2GZ7|rcsb pdb:2GZ8|rcsb pdb:2GZ9|rcsb pdb:2H2Z|rcsb pdb:2HOB|rcsb pdb:2HSX|rcsb pdb:2IDY|rcsb pdb:2KAF|rcsb pdb:2KQV|rcsb pdb:2KQW|rcsb pdb:2KYS|rcsb pdb:2LIZ|rcsb pdb:2OP9|rcsb pdb:2PWX|rcsb pdb:2W2G|rcsb pdb:2WCT|rcsb pdb:2Z3C|rcsb pdb:2Z3D|rcsb pdb:2Z3E|rcsb pdb:2ZU4|rcsb pdb:2ZU5|rcsb pdb:3ATW|rcsb pdb:3AVZ|rcsb pdb:3AW0|rcsb pdb:3AW1|rcsb pdb:3E91|rcsb pdb:3EA7|rcsb pdb:3EA8|rcsb pdb:3EA9|rcsb pdb:3EAJ|rcsb pdb:3EE7|rcsb pdb:3F9E|rcsb pdb:3F9F|rcsb pdb:3F9G|rcsb pdb:3F9H|rcsb pdb:3FZD|rcsb pdb:3IWM|rcsb pdb:3M3S|rcsb pdb:3M3T|rcsb pdb:3M3V|rcsb pdb:3MJ5|rcsb pdb:3R24|rcsb pdb:3SN8|rcsb pdb:3SNA|rcsb pdb:3SNB|rcsb pdb:3SNC|rcsb pdb:3SND|rcsb pdb:3SNE|rcsb pdb:1UK2|rcsb pdb:3SZN|rcsb pdb:3TIT|rcsb pdb:3TIU|rcsb pdb:3TNS|rcsb pdb:3TNT|rcsb pdb:3V3M|rcsb pdb:3VB3|rcsb pdb:3VB4|rcsb pdb:3VB5|rcsb pdb:3VB6|rcsb pdb:3VB7|rcsb pdb:4HI3|rcsb pdb:4M0W|rcsb pdb:4MDS|rcsb pdb:4MM3|rcsb pdb:4OVZ|rcsb pdb:4OW0|rcsb pdb:5F22|rcsb pdb:5Y3E|rcsb pdb:5Y3Q|rcsb pdb:6LNY|rcsb pdb:6NUR|rcsb pdb:6NUS|rcsb pdb:6W2A|rcsb pdb:6XHL|rcsb pdb:6XHN|rcsb pdb:6XHO|rcsb pdb:6Y7M|rcsb pdb:6YXJ|rcsb pdb:6LO0|reactome:R-HSA-9679504|reactome:R-HSA-9682706|reactome:R-HSA-9682708|reactome:R-HSA-9683439|reactome:R-HSA-9684325|dip:DIP-48580N	go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019079"(viral genome replication)|go:"GO:0019082"(viral protein processing)|go:"GO:0019083"(viral transcription)|go:"GO:0019785"(ISG15-specific protease activity)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039501"(suppression by virus of host type I interferon production)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039519"(modulation by virus of host autophagy)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039547"(suppression by virus of host TRAF activity)|go:"GO:0039548"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity)|go:"GO:0039579"(suppression by virus of host ISG15-protein conjugation)|go:"GO:0039595"(induction by virus of catabolism of host mRNA)|go:"GO:0039644"(suppression by virus of host NF-kappaB cascade)|go:"GO:0039648"(modulation by virus of host protein ubiquitination)|go:"GO:0039690"(positive stranded viral RNA replication)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039714"(cytoplasmic viral factory)|go:"GO:0039722"(suppression by virus of host toll-like receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0062243"(double membrane vesicle viral factory outer membrane)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|interpro:IPR002589(Appr-1-p processing)|interpro:IPR008740(Peptidase C30, Coronavirus endopeptidase)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR013016(Peptidase C30/C16)|interpro:IPR014822(Nsp9 replicase)|interpro:IPR014828(Nsp7 replicase)|interpro:IPR014829(Nsp8 replicase)|interpro:IPR018995|interpro:IPR021590|interpro:IPR022733|interpro:IPR024358|interpro:IPR024375|interpro:IPR032505|interpro:IPR032592|interpro:IPR036333|interpro:IPR036499|interpro:IPR037204|interpro:IPR037230|interpro:IPR038030|interpro:IPR038083|interpro:IPR038123|interpro:IPR038166|interpro:IPR038400|interpro:IPR042570|interpro:IPR043177|interpro:IPR043178|interpro:IPR043472|interpro:IPR043477|interpro:IPR043478|interpro:IPR043503|interpro:IPR043504|interpro:IPR043610|interpro:IPR043611|interpro:IPR043612|interpro:IPR043613|interpro:IPR043615|interpro:IPR044353|interpro:IPR044357|interpro:IPR044367|interpro:IPR044371|interpro:IPR044374|interpro:IPR044389|rcsb pdb:1P76|rcsb pdb:1P9T|rcsb pdb:1PA5|rcsb pdb:1PUK|go:"GO:0039604"(suppression by virus of host translation)|rcsb pdb:1Q1X|rcsb pdb:1Q2W|rcsb pdb:1QZ8|rcsb pdb:1UJ1|rcsb pdb:1UK3|rcsb pdb:1UK4|rcsb pdb:1UW7|rcsb pdb:1WOF|rcsb pdb:1YSY|rcsb pdb:1Z1I|rcsb pdb:1Z1J|rcsb pdb:2A5A|rcsb pdb:2A5I|rcsb pdb:2A5K|rcsb pdb:2ACF|rcsb pdb:2AHM|rcsb pdb:2AJ5|rcsb pdb:2ALV|rcsb pdb:2AMD|rcsb pdb:2AMQ|rcsb pdb:2BX3|rcsb pdb:2BX4|rcsb pdb:2C3S|rcsb pdb:2D2D|rcsb pdb:2DUC|rcsb pdb:2FAV|rcsb pdb:2FE8|rcsb pdb:2FYG|rcsb pdb:2G9T|rcsb pdb:2GA6|rcsb pdb:2GDT|rcsb pdb:2GRI|rcsb pdb:2GT7|rcsb pdb:2GT8|rcsb pdb:2GTB|rcsb pdb:2GX4|rcsb pdb:2GZ7|rcsb pdb:2GZ8|rcsb pdb:2GZ9|rcsb pdb:2H2Z|rcsb pdb:2HOB|rcsb pdb:2HSX|rcsb pdb:2IDY|rcsb pdb:2KAF|rcsb pdb:2KQV|rcsb pdb:2KQW|rcsb pdb:2KYS|rcsb pdb:2LIZ|rcsb pdb:2OP9|rcsb pdb:2PWX|rcsb pdb:2W2G|rcsb pdb:2WCT|rcsb pdb:2Z3C|rcsb pdb:2Z3D|rcsb pdb:2Z3E|rcsb pdb:2ZU4|rcsb pdb:2ZU5|rcsb pdb:3ATW|rcsb pdb:3AVZ|rcsb pdb:3AW0|rcsb pdb:3AW1|rcsb pdb:3E91|rcsb pdb:3EA7|rcsb pdb:3EA8|rcsb pdb:3EA9|rcsb pdb:3EAJ|rcsb pdb:3EE7|rcsb pdb:3F9E|rcsb pdb:3F9F|rcsb pdb:3F9G|rcsb pdb:3F9H|rcsb pdb:3FZD|rcsb pdb:3IWM|rcsb pdb:3M3S|rcsb pdb:3M3T|rcsb pdb:3M3V|rcsb pdb:3MJ5|rcsb pdb:3R24|rcsb pdb:3SN8|rcsb pdb:3SNA|rcsb pdb:3SNB|rcsb pdb:3SNC|rcsb pdb:3SND|rcsb pdb:3SNE|rcsb pdb:1UK2|rcsb pdb:3SZN|rcsb pdb:3TIT|rcsb pdb:3TIU|rcsb pdb:3TNS|rcsb pdb:3TNT|rcsb pdb:3V3M|rcsb pdb:3VB3|rcsb pdb:3VB4|rcsb pdb:3VB5|rcsb pdb:3VB6|rcsb pdb:3VB7|rcsb pdb:4HI3|rcsb pdb:4M0W|rcsb pdb:4MDS|rcsb pdb:4MM3|rcsb pdb:4OVZ|rcsb pdb:4OW0|rcsb pdb:5F22|rcsb pdb:5Y3E|rcsb pdb:5Y3Q|rcsb pdb:6LNY|rcsb pdb:6NUR|rcsb pdb:6NUS|rcsb pdb:6W2A|rcsb pdb:6XHL|rcsb pdb:6XHN|rcsb pdb:6XHO|rcsb pdb:6Y7M|rcsb pdb:6YXJ|rcsb pdb:6LO0|reactome:R-HSA-9679504|reactome:R-HSA-9682706|reactome:R-HSA-9682708|reactome:R-HSA-9683439|reactome:R-HSA-9684325|dip:DIP-48580N	-	-	-	figure legend:Figs. 2a-b, S4-2|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/04/21	2020/05/18	rogid:zwPSRRjRlqC4IBqawJVQzY4HMGs694009	rogid:zwPSRRjRlqC4IBqawJVQzY4HMGs694009	rigid:HMwPu9Xqpte8SlLRFljXrZoq5BQ	false	green fluorescent protein tag:?-?|sufficient binding region:3527-3556,3231-3250|s tag:n-n|his tag:c-c|mutation:3549-3549|mutation:3549-3549|mutation:3243-3243|mutation:3243-3243	sufficient binding region:3231-3546|s tag:n-n|mutation decreasing interaction rate:3240-3240	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:P0C6U8-PRO_0000338259	uniprotkb:P0C6U8	intact:EBI-25496008	intact:EBI-15810860|uniprotkb:P59641	psi-mi:p0c6u8-pro_0000338259(display_long)|uniprotkb:ORF1a polyprotein(gene name synonym)|uniprotkb:1a(orf name)	psi-mi:r1a_sars(display_long)|uniprotkb:ORF1a polyprotein(gene name synonym)|uniprotkb:1a(orf name)	psi-mi:"MI:0435"(protease assay)	Muramatsu et al. (2016)	pubmed:27799534|imex:IM-27932	taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus)	taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25590255|imex:IM-27932-16	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-15810860(chain-parent)	go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019079"(viral genome replication)|go:"GO:0019082"(viral protein processing)|go:"GO:0019083"(viral transcription)|go:"GO:0019785"(ISG15-specific protease activity)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039501"(suppression by virus of host type I interferon production)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039519"(modulation by virus of host autophagy)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039547"(suppression by virus of host TRAF activity)|go:"GO:0039548"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity)|go:"GO:0039579"(suppression by virus of host ISG15-protein conjugation)|go:"GO:0039595"(induction by virus of catabolism of host mRNA)|go:"GO:0039644"(suppression by virus of host NF-kappaB cascade)|go:"GO:0039648"(modulation by virus of host protein ubiquitination)|go:"GO:0039690"(positive stranded viral RNA replication)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039714"(cytoplasmic viral factory)|go:"GO:0039722"(suppression by virus of host toll-like receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0062243"(double membrane vesicle viral factory outer membrane)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|interpro:IPR002589(Appr-1-p processing)|interpro:IPR008740(Peptidase C30, Coronavirus endopeptidase)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR013016(Peptidase C30/C16)|interpro:IPR014822(Nsp9 replicase)|interpro:IPR014828(Nsp7 replicase)|interpro:IPR014829(Nsp8 replicase)|interpro:IPR018995|interpro:IPR021590|interpro:IPR022733|interpro:IPR024358|interpro:IPR024375|interpro:IPR032505|interpro:IPR032592|interpro:IPR036333|interpro:IPR036499|interpro:IPR037204|interpro:IPR037230|interpro:IPR038030|interpro:IPR038083|interpro:IPR038123|interpro:IPR038166|interpro:IPR038400|interpro:IPR042570|interpro:IPR043177|interpro:IPR043178|interpro:IPR043472|interpro:IPR043477|interpro:IPR043478|interpro:IPR043503|interpro:IPR043504|interpro:IPR043610|interpro:IPR043611|interpro:IPR043612|interpro:IPR043613|interpro:IPR043615|interpro:IPR044353|interpro:IPR044357|interpro:IPR044367|interpro:IPR044371|interpro:IPR044374|interpro:IPR044389|rcsb pdb:1P76|rcsb pdb:1P9T|rcsb pdb:1PA5|rcsb pdb:1PUK|go:"GO:0039604"(suppression by virus of host translation)|rcsb pdb:1Q1X|rcsb pdb:1Q2W|rcsb pdb:1QZ8|rcsb pdb:1UJ1|rcsb pdb:1UK3|rcsb pdb:1UK4|rcsb pdb:1UW7|rcsb pdb:1WOF|rcsb pdb:1YSY|rcsb pdb:1Z1I|rcsb pdb:1Z1J|rcsb pdb:2A5A|rcsb pdb:2A5I|rcsb pdb:2A5K|rcsb pdb:2ACF|rcsb pdb:2AHM|rcsb pdb:2AJ5|rcsb pdb:2ALV|rcsb pdb:2AMD|rcsb pdb:2AMQ|rcsb pdb:2BX3|rcsb pdb:2BX4|rcsb pdb:2C3S|rcsb pdb:2D2D|rcsb pdb:2DUC|rcsb pdb:2FAV|rcsb pdb:2FE8|rcsb pdb:2FYG|rcsb pdb:2G9T|rcsb pdb:2GA6|rcsb pdb:2GDT|rcsb pdb:2GRI|rcsb pdb:2GT7|rcsb pdb:2GT8|rcsb pdb:2GTB|rcsb pdb:2GX4|rcsb pdb:2GZ7|rcsb pdb:2GZ8|rcsb pdb:2GZ9|rcsb pdb:2H2Z|rcsb pdb:2HOB|rcsb pdb:2HSX|rcsb pdb:2IDY|rcsb pdb:2KAF|rcsb pdb:2KQV|rcsb pdb:2KQW|rcsb pdb:2KYS|rcsb pdb:2LIZ|rcsb pdb:2OP9|rcsb pdb:2PWX|rcsb pdb:2W2G|rcsb pdb:2WCT|rcsb pdb:2Z3C|rcsb pdb:2Z3D|rcsb pdb:2Z3E|rcsb pdb:2ZU4|rcsb pdb:2ZU5|rcsb pdb:3ATW|rcsb pdb:3AVZ|rcsb pdb:3AW0|rcsb pdb:3AW1|rcsb pdb:3E91|rcsb pdb:3EA7|rcsb pdb:3EA8|rcsb pdb:3EA9|rcsb pdb:3EAJ|rcsb pdb:3EE7|rcsb pdb:3F9E|rcsb pdb:3F9F|rcsb pdb:3F9G|rcsb pdb:3F9H|rcsb pdb:3FZD|rcsb pdb:3IWM|rcsb pdb:3M3S|rcsb pdb:3M3T|rcsb pdb:3M3V|rcsb pdb:3MJ5|rcsb pdb:3R24|rcsb pdb:3SN8|rcsb pdb:3SNA|rcsb pdb:3SNB|rcsb pdb:3SNC|rcsb pdb:3SND|rcsb pdb:3SNE|rcsb pdb:1UK2|rcsb pdb:3SZN|rcsb pdb:3TIT|rcsb pdb:3TIU|rcsb pdb:3TNS|rcsb pdb:3TNT|rcsb pdb:3V3M|rcsb pdb:3VB3|rcsb pdb:3VB4|rcsb pdb:3VB5|rcsb pdb:3VB6|rcsb pdb:3VB7|rcsb pdb:4HI3|rcsb pdb:4M0W|rcsb pdb:4MDS|rcsb pdb:4MM3|rcsb pdb:4OVZ|rcsb pdb:4OW0|rcsb pdb:5F22|rcsb pdb:5Y3E|rcsb pdb:5Y3Q|rcsb pdb:6LNY|rcsb pdb:6NUR|rcsb pdb:6NUS|rcsb pdb:6W2A|rcsb pdb:6XHL|rcsb pdb:6XHN|rcsb pdb:6XHO|rcsb pdb:6Y7M|rcsb pdb:6YXJ|rcsb pdb:6LO0|reactome:R-HSA-9679504|reactome:R-HSA-9682706|reactome:R-HSA-9682708|reactome:R-HSA-9683439|reactome:R-HSA-9684325|dip:DIP-48580N	-	chain-seq-start:3241|chain-seq-end:3546	-	figure legend:Figs. 2a-e, S4-1|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/04/21	2020/05/18	rogid:6LbRC/jITHtqNPZLpKst/+pNdOQ694009	rogid:zwPSRRjRlqC4IBqawJVQzY4HMGs694009	rigid:FuAHBofdR4LJLRbJSg6j0fAa4XI	false	-	green fluorescent protein tag:?-?|sufficient binding region:3527-3556,3231-3250|s tag:n-n|his tag:c-c|mutation decreasing interaction rate:3549-3549|mutation decreasing interaction rate:3549-3549|mutation with no effect:3243-3243|mutation with no effect:3243-3243	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:P0C6U8	uniprotkb:P0C6U8	intact:EBI-15810860|uniprotkb:P59641	intact:EBI-15810860|uniprotkb:P59641	psi-mi:r1a_sars(display_long)|uniprotkb:ORF1a polyprotein(gene name synonym)|uniprotkb:1a(orf name)	psi-mi:r1a_sars(display_long)|uniprotkb:ORF1a polyprotein(gene name synonym)|uniprotkb:1a(orf name)	psi-mi:"MI:0435"(protease assay)	Muramatsu et al. (2016)	pubmed:27799534|imex:IM-27932	taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus)	taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25590312|imex:IM-27932-18	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019079"(viral genome replication)|go:"GO:0019082"(viral protein processing)|go:"GO:0019083"(viral transcription)|go:"GO:0019785"(ISG15-specific protease activity)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039501"(suppression by virus of host type I interferon production)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039519"(modulation by virus of host autophagy)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039547"(suppression by virus of host TRAF activity)|go:"GO:0039548"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity)|go:"GO:0039579"(suppression by virus of host ISG15-protein conjugation)|go:"GO:0039595"(induction by virus of catabolism of host mRNA)|go:"GO:0039644"(suppression by virus of host NF-kappaB cascade)|go:"GO:0039648"(modulation by virus of host protein ubiquitination)|go:"GO:0039690"(positive stranded viral RNA replication)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039714"(cytoplasmic viral factory)|go:"GO:0039722"(suppression by virus of host toll-like receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0062243"(double membrane vesicle viral factory outer membrane)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|interpro:IPR002589(Appr-1-p processing)|interpro:IPR008740(Peptidase C30, Coronavirus endopeptidase)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR013016(Peptidase C30/C16)|interpro:IPR014822(Nsp9 replicase)|interpro:IPR014828(Nsp7 replicase)|interpro:IPR014829(Nsp8 replicase)|interpro:IPR018995|interpro:IPR021590|interpro:IPR022733|interpro:IPR024358|interpro:IPR024375|interpro:IPR032505|interpro:IPR032592|interpro:IPR036333|interpro:IPR036499|interpro:IPR037204|interpro:IPR037230|interpro:IPR038030|interpro:IPR038083|interpro:IPR038123|interpro:IPR038166|interpro:IPR038400|interpro:IPR042570|interpro:IPR043177|interpro:IPR043178|interpro:IPR043472|interpro:IPR043477|interpro:IPR043478|interpro:IPR043503|interpro:IPR043504|interpro:IPR043610|interpro:IPR043611|interpro:IPR043612|interpro:IPR043613|interpro:IPR043615|interpro:IPR044353|interpro:IPR044357|interpro:IPR044367|interpro:IPR044371|interpro:IPR044374|interpro:IPR044389|rcsb pdb:1P76|rcsb pdb:1P9T|rcsb pdb:1PA5|rcsb pdb:1PUK|go:"GO:0039604"(suppression by virus of host translation)|rcsb pdb:1Q1X|rcsb pdb:1Q2W|rcsb pdb:1QZ8|rcsb pdb:1UJ1|rcsb pdb:1UK3|rcsb pdb:1UK4|rcsb pdb:1UW7|rcsb pdb:1WOF|rcsb pdb:1YSY|rcsb pdb:1Z1I|rcsb pdb:1Z1J|rcsb pdb:2A5A|rcsb pdb:2A5I|rcsb pdb:2A5K|rcsb pdb:2ACF|rcsb pdb:2AHM|rcsb pdb:2AJ5|rcsb pdb:2ALV|rcsb pdb:2AMD|rcsb pdb:2AMQ|rcsb pdb:2BX3|rcsb pdb:2BX4|rcsb pdb:2C3S|rcsb pdb:2D2D|rcsb pdb:2DUC|rcsb pdb:2FAV|rcsb pdb:2FE8|rcsb pdb:2FYG|rcsb pdb:2G9T|rcsb pdb:2GA6|rcsb pdb:2GDT|rcsb pdb:2GRI|rcsb pdb:2GT7|rcsb pdb:2GT8|rcsb pdb:2GTB|rcsb pdb:2GX4|rcsb pdb:2GZ7|rcsb pdb:2GZ8|rcsb pdb:2GZ9|rcsb pdb:2H2Z|rcsb pdb:2HOB|rcsb pdb:2HSX|rcsb pdb:2IDY|rcsb pdb:2KAF|rcsb pdb:2KQV|rcsb pdb:2KQW|rcsb pdb:2KYS|rcsb pdb:2LIZ|rcsb pdb:2OP9|rcsb pdb:2PWX|rcsb pdb:2W2G|rcsb pdb:2WCT|rcsb pdb:2Z3C|rcsb pdb:2Z3D|rcsb pdb:2Z3E|rcsb pdb:2ZU4|rcsb pdb:2ZU5|rcsb pdb:3ATW|rcsb pdb:3AVZ|rcsb pdb:3AW0|rcsb pdb:3AW1|rcsb pdb:3E91|rcsb pdb:3EA7|rcsb pdb:3EA8|rcsb pdb:3EA9|rcsb pdb:3EAJ|rcsb pdb:3EE7|rcsb pdb:3F9E|rcsb pdb:3F9F|rcsb pdb:3F9G|rcsb pdb:3F9H|rcsb pdb:3FZD|rcsb pdb:3IWM|rcsb pdb:3M3S|rcsb pdb:3M3T|rcsb pdb:3M3V|rcsb pdb:3MJ5|rcsb pdb:3R24|rcsb pdb:3SN8|rcsb pdb:3SNA|rcsb pdb:3SNB|rcsb pdb:3SNC|rcsb pdb:3SND|rcsb pdb:3SNE|rcsb pdb:1UK2|rcsb pdb:3SZN|rcsb pdb:3TIT|rcsb pdb:3TIU|rcsb pdb:3TNS|rcsb pdb:3TNT|rcsb pdb:3V3M|rcsb pdb:3VB3|rcsb pdb:3VB4|rcsb pdb:3VB5|rcsb pdb:3VB6|rcsb pdb:3VB7|rcsb pdb:4HI3|rcsb pdb:4M0W|rcsb pdb:4MDS|rcsb pdb:4MM3|rcsb pdb:4OVZ|rcsb pdb:4OW0|rcsb pdb:5F22|rcsb pdb:5Y3E|rcsb pdb:5Y3Q|rcsb pdb:6LNY|rcsb pdb:6NUR|rcsb pdb:6NUS|rcsb pdb:6W2A|rcsb pdb:6XHL|rcsb pdb:6XHN|rcsb pdb:6XHO|rcsb pdb:6Y7M|rcsb pdb:6YXJ|rcsb pdb:6LO0|reactome:R-HSA-9679504|reactome:R-HSA-9682706|reactome:R-HSA-9682708|reactome:R-HSA-9683439|reactome:R-HSA-9684325|dip:DIP-48580N	go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019079"(viral genome replication)|go:"GO:0019082"(viral protein processing)|go:"GO:0019083"(viral transcription)|go:"GO:0019785"(ISG15-specific protease activity)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039501"(suppression by virus of host type I interferon production)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039519"(modulation by virus of host autophagy)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039547"(suppression by virus of host TRAF activity)|go:"GO:0039548"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity)|go:"GO:0039579"(suppression by virus of host ISG15-protein conjugation)|go:"GO:0039595"(induction by virus of catabolism of host mRNA)|go:"GO:0039644"(suppression by virus of host NF-kappaB cascade)|go:"GO:0039648"(modulation by virus of host protein ubiquitination)|go:"GO:0039690"(positive stranded viral RNA replication)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039714"(cytoplasmic viral factory)|go:"GO:0039722"(suppression by virus of host toll-like receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0062243"(double membrane vesicle viral factory outer membrane)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|interpro:IPR002589(Appr-1-p processing)|interpro:IPR008740(Peptidase C30, Coronavirus endopeptidase)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR013016(Peptidase C30/C16)|interpro:IPR014822(Nsp9 replicase)|interpro:IPR014828(Nsp7 replicase)|interpro:IPR014829(Nsp8 replicase)|interpro:IPR018995|interpro:IPR021590|interpro:IPR022733|interpro:IPR024358|interpro:IPR024375|interpro:IPR032505|interpro:IPR032592|interpro:IPR036333|interpro:IPR036499|interpro:IPR037204|interpro:IPR037230|interpro:IPR038030|interpro:IPR038083|interpro:IPR038123|interpro:IPR038166|interpro:IPR038400|interpro:IPR042570|interpro:IPR043177|interpro:IPR043178|interpro:IPR043472|interpro:IPR043477|interpro:IPR043478|interpro:IPR043503|interpro:IPR043504|interpro:IPR043610|interpro:IPR043611|interpro:IPR043612|interpro:IPR043613|interpro:IPR043615|interpro:IPR044353|interpro:IPR044357|interpro:IPR044367|interpro:IPR044371|interpro:IPR044374|interpro:IPR044389|rcsb pdb:1P76|rcsb pdb:1P9T|rcsb pdb:1PA5|rcsb pdb:1PUK|go:"GO:0039604"(suppression by virus of host translation)|rcsb pdb:1Q1X|rcsb pdb:1Q2W|rcsb pdb:1QZ8|rcsb pdb:1UJ1|rcsb pdb:1UK3|rcsb pdb:1UK4|rcsb pdb:1UW7|rcsb pdb:1WOF|rcsb pdb:1YSY|rcsb pdb:1Z1I|rcsb pdb:1Z1J|rcsb pdb:2A5A|rcsb pdb:2A5I|rcsb pdb:2A5K|rcsb pdb:2ACF|rcsb pdb:2AHM|rcsb pdb:2AJ5|rcsb pdb:2ALV|rcsb pdb:2AMD|rcsb pdb:2AMQ|rcsb pdb:2BX3|rcsb pdb:2BX4|rcsb pdb:2C3S|rcsb pdb:2D2D|rcsb pdb:2DUC|rcsb pdb:2FAV|rcsb pdb:2FE8|rcsb pdb:2FYG|rcsb pdb:2G9T|rcsb pdb:2GA6|rcsb pdb:2GDT|rcsb pdb:2GRI|rcsb pdb:2GT7|rcsb pdb:2GT8|rcsb pdb:2GTB|rcsb pdb:2GX4|rcsb pdb:2GZ7|rcsb pdb:2GZ8|rcsb pdb:2GZ9|rcsb pdb:2H2Z|rcsb pdb:2HOB|rcsb pdb:2HSX|rcsb pdb:2IDY|rcsb pdb:2KAF|rcsb pdb:2KQV|rcsb pdb:2KQW|rcsb pdb:2KYS|rcsb pdb:2LIZ|rcsb pdb:2OP9|rcsb pdb:2PWX|rcsb pdb:2W2G|rcsb pdb:2WCT|rcsb pdb:2Z3C|rcsb pdb:2Z3D|rcsb pdb:2Z3E|rcsb pdb:2ZU4|rcsb pdb:2ZU5|rcsb pdb:3ATW|rcsb pdb:3AVZ|rcsb pdb:3AW0|rcsb pdb:3AW1|rcsb pdb:3E91|rcsb pdb:3EA7|rcsb pdb:3EA8|rcsb pdb:3EA9|rcsb pdb:3EAJ|rcsb pdb:3EE7|rcsb pdb:3F9E|rcsb pdb:3F9F|rcsb pdb:3F9G|rcsb pdb:3F9H|rcsb pdb:3FZD|rcsb pdb:3IWM|rcsb pdb:3M3S|rcsb pdb:3M3T|rcsb pdb:3M3V|rcsb pdb:3MJ5|rcsb pdb:3R24|rcsb pdb:3SN8|rcsb pdb:3SNA|rcsb pdb:3SNB|rcsb pdb:3SNC|rcsb pdb:3SND|rcsb pdb:3SNE|rcsb pdb:1UK2|rcsb pdb:3SZN|rcsb pdb:3TIT|rcsb pdb:3TIU|rcsb pdb:3TNS|rcsb pdb:3TNT|rcsb pdb:3V3M|rcsb pdb:3VB3|rcsb pdb:3VB4|rcsb pdb:3VB5|rcsb pdb:3VB6|rcsb pdb:3VB7|rcsb pdb:4HI3|rcsb pdb:4M0W|rcsb pdb:4MDS|rcsb pdb:4MM3|rcsb pdb:4OVZ|rcsb pdb:4OW0|rcsb pdb:5F22|rcsb pdb:5Y3E|rcsb pdb:5Y3Q|rcsb pdb:6LNY|rcsb pdb:6NUR|rcsb pdb:6NUS|rcsb pdb:6W2A|rcsb pdb:6XHL|rcsb pdb:6XHN|rcsb pdb:6XHO|rcsb pdb:6Y7M|rcsb pdb:6YXJ|rcsb pdb:6LO0|reactome:R-HSA-9679504|reactome:R-HSA-9682706|reactome:R-HSA-9682708|reactome:R-HSA-9683439|reactome:R-HSA-9684325|dip:DIP-48580N	-	-	-	figure legend:Figs. 2a-e, S4-4|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/04/21	2020/05/18	rogid:zwPSRRjRlqC4IBqawJVQzY4HMGs694009	rogid:zwPSRRjRlqC4IBqawJVQzY4HMGs694009	rigid:HMwPu9Xqpte8SlLRFljXrZoq5BQ	false	green fluorescent protein tag:?-?|sufficient binding region:3527-3556,3231-3250|s tag:n-n|his tag:c-c|mutation:3549-3549|mutation:3549-3549|mutation:3243-3243|mutation:3243-3243	s tag:n-n|sufficient binding region:3231-3556|his tag:c-c|mutation decreasing interaction rate:3546-3546,3240-3240	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:P0C6U8-PRO_0000338259	uniprotkb:P0C6U8	intact:EBI-25496008	intact:EBI-15810860|uniprotkb:P59641	psi-mi:p0c6u8-pro_0000338259(display_long)|uniprotkb:ORF1a polyprotein(gene name synonym)|uniprotkb:1a(orf name)	psi-mi:r1a_sars(display_long)|uniprotkb:ORF1a polyprotein(gene name synonym)|uniprotkb:1a(orf name)	psi-mi:"MI:0435"(protease assay)	Muramatsu et al. (2016)	pubmed:27799534|imex:IM-27932	taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus)	taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25590665|imex:IM-27932-20	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-15810860(chain-parent)	go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019079"(viral genome replication)|go:"GO:0019082"(viral protein processing)|go:"GO:0019083"(viral transcription)|go:"GO:0019785"(ISG15-specific protease activity)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039501"(suppression by virus of host type I interferon production)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039519"(modulation by virus of host autophagy)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039547"(suppression by virus of host TRAF activity)|go:"GO:0039548"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity)|go:"GO:0039579"(suppression by virus of host ISG15-protein conjugation)|go:"GO:0039595"(induction by virus of catabolism of host mRNA)|go:"GO:0039644"(suppression by virus of host NF-kappaB cascade)|go:"GO:0039648"(modulation by virus of host protein ubiquitination)|go:"GO:0039690"(positive stranded viral RNA replication)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039714"(cytoplasmic viral factory)|go:"GO:0039722"(suppression by virus of host toll-like receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0062243"(double membrane vesicle viral factory outer membrane)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|interpro:IPR002589(Appr-1-p processing)|interpro:IPR008740(Peptidase C30, Coronavirus endopeptidase)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR013016(Peptidase C30/C16)|interpro:IPR014822(Nsp9 replicase)|interpro:IPR014828(Nsp7 replicase)|interpro:IPR014829(Nsp8 replicase)|interpro:IPR018995|interpro:IPR021590|interpro:IPR022733|interpro:IPR024358|interpro:IPR024375|interpro:IPR032505|interpro:IPR032592|interpro:IPR036333|interpro:IPR036499|interpro:IPR037204|interpro:IPR037230|interpro:IPR038030|interpro:IPR038083|interpro:IPR038123|interpro:IPR038166|interpro:IPR038400|interpro:IPR042570|interpro:IPR043177|interpro:IPR043178|interpro:IPR043472|interpro:IPR043477|interpro:IPR043478|interpro:IPR043503|interpro:IPR043504|interpro:IPR043610|interpro:IPR043611|interpro:IPR043612|interpro:IPR043613|interpro:IPR043615|interpro:IPR044353|interpro:IPR044357|interpro:IPR044367|interpro:IPR044371|interpro:IPR044374|interpro:IPR044389|rcsb pdb:1P76|rcsb pdb:1P9T|rcsb pdb:1PA5|rcsb pdb:1PUK|go:"GO:0039604"(suppression by virus of host translation)|rcsb pdb:1Q1X|rcsb pdb:1Q2W|rcsb pdb:1QZ8|rcsb pdb:1UJ1|rcsb pdb:1UK3|rcsb pdb:1UK4|rcsb pdb:1UW7|rcsb pdb:1WOF|rcsb pdb:1YSY|rcsb pdb:1Z1I|rcsb pdb:1Z1J|rcsb pdb:2A5A|rcsb pdb:2A5I|rcsb pdb:2A5K|rcsb pdb:2ACF|rcsb pdb:2AHM|rcsb pdb:2AJ5|rcsb pdb:2ALV|rcsb pdb:2AMD|rcsb pdb:2AMQ|rcsb pdb:2BX3|rcsb pdb:2BX4|rcsb pdb:2C3S|rcsb pdb:2D2D|rcsb pdb:2DUC|rcsb pdb:2FAV|rcsb pdb:2FE8|rcsb pdb:2FYG|rcsb pdb:2G9T|rcsb pdb:2GA6|rcsb pdb:2GDT|rcsb pdb:2GRI|rcsb pdb:2GT7|rcsb pdb:2GT8|rcsb pdb:2GTB|rcsb pdb:2GX4|rcsb pdb:2GZ7|rcsb pdb:2GZ8|rcsb pdb:2GZ9|rcsb pdb:2H2Z|rcsb pdb:2HOB|rcsb pdb:2HSX|rcsb pdb:2IDY|rcsb pdb:2KAF|rcsb pdb:2KQV|rcsb pdb:2KQW|rcsb pdb:2KYS|rcsb pdb:2LIZ|rcsb pdb:2OP9|rcsb pdb:2PWX|rcsb pdb:2W2G|rcsb pdb:2WCT|rcsb pdb:2Z3C|rcsb pdb:2Z3D|rcsb pdb:2Z3E|rcsb pdb:2ZU4|rcsb pdb:2ZU5|rcsb pdb:3ATW|rcsb pdb:3AVZ|rcsb pdb:3AW0|rcsb pdb:3AW1|rcsb pdb:3E91|rcsb pdb:3EA7|rcsb pdb:3EA8|rcsb pdb:3EA9|rcsb pdb:3EAJ|rcsb pdb:3EE7|rcsb pdb:3F9E|rcsb pdb:3F9F|rcsb pdb:3F9G|rcsb pdb:3F9H|rcsb pdb:3FZD|rcsb pdb:3IWM|rcsb pdb:3M3S|rcsb pdb:3M3T|rcsb pdb:3M3V|rcsb pdb:3MJ5|rcsb pdb:3R24|rcsb pdb:3SN8|rcsb pdb:3SNA|rcsb pdb:3SNB|rcsb pdb:3SNC|rcsb pdb:3SND|rcsb pdb:3SNE|rcsb pdb:1UK2|rcsb pdb:3SZN|rcsb pdb:3TIT|rcsb pdb:3TIU|rcsb pdb:3TNS|rcsb pdb:3TNT|rcsb pdb:3V3M|rcsb pdb:3VB3|rcsb pdb:3VB4|rcsb pdb:3VB5|rcsb pdb:3VB6|rcsb pdb:3VB7|rcsb pdb:4HI3|rcsb pdb:4M0W|rcsb pdb:4MDS|rcsb pdb:4MM3|rcsb pdb:4OVZ|rcsb pdb:4OW0|rcsb pdb:5F22|rcsb pdb:5Y3E|rcsb pdb:5Y3Q|rcsb pdb:6LNY|rcsb pdb:6NUR|rcsb pdb:6NUS|rcsb pdb:6W2A|rcsb pdb:6XHL|rcsb pdb:6XHN|rcsb pdb:6XHO|rcsb pdb:6Y7M|rcsb pdb:6YXJ|rcsb pdb:6LO0|reactome:R-HSA-9679504|reactome:R-HSA-9682706|reactome:R-HSA-9682708|reactome:R-HSA-9683439|reactome:R-HSA-9684325|dip:DIP-48580N	-	chain-seq-start:3241|chain-seq-end:3546	-	figure legend:Figs. 2a-e, S4-5|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/04/21	2020/05/18	rogid:6LbRC/jITHtqNPZLpKst/+pNdOQ694009	rogid:zwPSRRjRlqC4IBqawJVQzY4HMGs694009	rigid:FuAHBofdR4LJLRbJSg6j0fAa4XI	false	-	mutation decreasing interaction rate:3545-3545|mutation decreasing interaction rate:3545-3545,3549-3549|mutation decreasing interaction rate:3545-3545,3549-3549|green fluorescent protein tag:?-?|sufficient binding region:3527-3556,3231-3250|s tag:n-n|his tag:c-c|mutation decreasing interaction rate:3549-3549|mutation decreasing interaction rate:3549-3549|mutation decreasing interaction rate:3243-3243|mutation decreasing interaction rate:3243-3243	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:P0C6U8	uniprotkb:P0C6U8-PRO_0000338259	intact:EBI-15810860|uniprotkb:P59641	intact:EBI-25496008	psi-mi:r1a_sars(display_long)|uniprotkb:ORF1a polyprotein(gene name synonym)|uniprotkb:1a(orf name)	psi-mi:p0c6u8-pro_0000338259(display_long)|uniprotkb:ORF1a polyprotein(gene name synonym)|uniprotkb:1a(orf name)	psi-mi:"MI:0435"(protease assay)	Muramatsu et al. (2016)	pubmed:27799534|imex:IM-27932	taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus)	taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25590706|imex:IM-27932-22	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019079"(viral genome replication)|go:"GO:0019082"(viral protein processing)|go:"GO:0019083"(viral transcription)|go:"GO:0019785"(ISG15-specific protease activity)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039501"(suppression by virus of host type I interferon production)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039519"(modulation by virus of host autophagy)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039547"(suppression by virus of host TRAF activity)|go:"GO:0039548"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity)|go:"GO:0039579"(suppression by virus of host ISG15-protein conjugation)|go:"GO:0039595"(induction by virus of catabolism of host mRNA)|go:"GO:0039644"(suppression by virus of host NF-kappaB cascade)|go:"GO:0039648"(modulation by virus of host protein ubiquitination)|go:"GO:0039690"(positive stranded viral RNA replication)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039714"(cytoplasmic viral factory)|go:"GO:0039722"(suppression by virus of host toll-like receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0062243"(double membrane vesicle viral factory outer membrane)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|interpro:IPR002589(Appr-1-p processing)|interpro:IPR008740(Peptidase C30, Coronavirus endopeptidase)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR013016(Peptidase C30/C16)|interpro:IPR014822(Nsp9 replicase)|interpro:IPR014828(Nsp7 replicase)|interpro:IPR014829(Nsp8 replicase)|interpro:IPR018995|interpro:IPR021590|interpro:IPR022733|interpro:IPR024358|interpro:IPR024375|interpro:IPR032505|interpro:IPR032592|interpro:IPR036333|interpro:IPR036499|interpro:IPR037204|interpro:IPR037230|interpro:IPR038030|interpro:IPR038083|interpro:IPR038123|interpro:IPR038166|interpro:IPR038400|interpro:IPR042570|interpro:IPR043177|interpro:IPR043178|interpro:IPR043472|interpro:IPR043477|interpro:IPR043478|interpro:IPR043503|interpro:IPR043504|interpro:IPR043610|interpro:IPR043611|interpro:IPR043612|interpro:IPR043613|interpro:IPR043615|interpro:IPR044353|interpro:IPR044357|interpro:IPR044367|interpro:IPR044371|interpro:IPR044374|interpro:IPR044389|rcsb pdb:1P76|rcsb pdb:1P9T|rcsb pdb:1PA5|rcsb pdb:1PUK|go:"GO:0039604"(suppression by virus of host translation)|rcsb pdb:1Q1X|rcsb pdb:1Q2W|rcsb pdb:1QZ8|rcsb pdb:1UJ1|rcsb pdb:1UK3|rcsb pdb:1UK4|rcsb pdb:1UW7|rcsb pdb:1WOF|rcsb pdb:1YSY|rcsb pdb:1Z1I|rcsb pdb:1Z1J|rcsb pdb:2A5A|rcsb pdb:2A5I|rcsb pdb:2A5K|rcsb pdb:2ACF|rcsb pdb:2AHM|rcsb pdb:2AJ5|rcsb pdb:2ALV|rcsb pdb:2AMD|rcsb pdb:2AMQ|rcsb pdb:2BX3|rcsb pdb:2BX4|rcsb pdb:2C3S|rcsb pdb:2D2D|rcsb pdb:2DUC|rcsb pdb:2FAV|rcsb pdb:2FE8|rcsb pdb:2FYG|rcsb pdb:2G9T|rcsb pdb:2GA6|rcsb pdb:2GDT|rcsb pdb:2GRI|rcsb pdb:2GT7|rcsb pdb:2GT8|rcsb pdb:2GTB|rcsb pdb:2GX4|rcsb pdb:2GZ7|rcsb pdb:2GZ8|rcsb pdb:2GZ9|rcsb pdb:2H2Z|rcsb pdb:2HOB|rcsb pdb:2HSX|rcsb pdb:2IDY|rcsb pdb:2KAF|rcsb pdb:2KQV|rcsb pdb:2KQW|rcsb pdb:2KYS|rcsb pdb:2LIZ|rcsb pdb:2OP9|rcsb pdb:2PWX|rcsb pdb:2W2G|rcsb pdb:2WCT|rcsb pdb:2Z3C|rcsb pdb:2Z3D|rcsb pdb:2Z3E|rcsb pdb:2ZU4|rcsb pdb:2ZU5|rcsb pdb:3ATW|rcsb pdb:3AVZ|rcsb pdb:3AW0|rcsb pdb:3AW1|rcsb pdb:3E91|rcsb pdb:3EA7|rcsb pdb:3EA8|rcsb pdb:3EA9|rcsb pdb:3EAJ|rcsb pdb:3EE7|rcsb pdb:3F9E|rcsb pdb:3F9F|rcsb pdb:3F9G|rcsb pdb:3F9H|rcsb pdb:3FZD|rcsb pdb:3IWM|rcsb pdb:3M3S|rcsb pdb:3M3T|rcsb pdb:3M3V|rcsb pdb:3MJ5|rcsb pdb:3R24|rcsb pdb:3SN8|rcsb pdb:3SNA|rcsb pdb:3SNB|rcsb pdb:3SNC|rcsb pdb:3SND|rcsb pdb:3SNE|rcsb pdb:1UK2|rcsb pdb:3SZN|rcsb pdb:3TIT|rcsb pdb:3TIU|rcsb pdb:3TNS|rcsb pdb:3TNT|rcsb pdb:3V3M|rcsb pdb:3VB3|rcsb pdb:3VB4|rcsb pdb:3VB5|rcsb pdb:3VB6|rcsb pdb:3VB7|rcsb pdb:4HI3|rcsb pdb:4M0W|rcsb pdb:4MDS|rcsb pdb:4MM3|rcsb pdb:4OVZ|rcsb pdb:4OW0|rcsb pdb:5F22|rcsb pdb:5Y3E|rcsb pdb:5Y3Q|rcsb pdb:6LNY|rcsb pdb:6NUR|rcsb pdb:6NUS|rcsb pdb:6W2A|rcsb pdb:6XHL|rcsb pdb:6XHN|rcsb pdb:6XHO|rcsb pdb:6Y7M|rcsb pdb:6YXJ|rcsb pdb:6LO0|reactome:R-HSA-9679504|reactome:R-HSA-9682706|reactome:R-HSA-9682708|reactome:R-HSA-9683439|reactome:R-HSA-9684325|dip:DIP-48580N	intact:EBI-15810860(chain-parent)	-	-	chain-seq-start:3241|chain-seq-end:3546	figure legend:Figs. 2a-e, S4-6|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/04/21	2020/05/18	rogid:zwPSRRjRlqC4IBqawJVQzY4HMGs694009	rogid:6LbRC/jITHtqNPZLpKst/+pNdOQ694009	rigid:FuAHBofdR4LJLRbJSg6j0fAa4XI	false	mutation:3545-3545|mutation:3545-3545,3549-3549|mutation:3545-3545,3549-3549|green fluorescent protein tag:?-?|sufficient binding region:3527-3556,3231-3250|s tag:n-n|his tag:c-c|mutation:3549-3549|mutation:3549-3549|mutation:3243-3243|mutation:3243-3243	mutation decreasing interaction rate:305-305	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:P0C6U8	uniprotkb:P0C6U8	intact:EBI-15810860|uniprotkb:P59641	intact:EBI-15810860|uniprotkb:P59641	psi-mi:r1a_sars(display_long)|uniprotkb:ORF1a polyprotein(gene name synonym)|uniprotkb:1a(orf name)	psi-mi:r1a_sars(display_long)|uniprotkb:ORF1a polyprotein(gene name synonym)|uniprotkb:1a(orf name)	psi-mi:"MI:0435"(protease assay)	Muramatsu et al. (2016)	pubmed:27799534|imex:IM-27932	taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus)	taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25590737|imex:IM-27932-24	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019079"(viral genome replication)|go:"GO:0019082"(viral protein processing)|go:"GO:0019083"(viral transcription)|go:"GO:0019785"(ISG15-specific protease activity)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039501"(suppression by virus of host type I interferon production)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039519"(modulation by virus of host autophagy)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039547"(suppression by virus of host TRAF activity)|go:"GO:0039548"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity)|go:"GO:0039579"(suppression by virus of host ISG15-protein conjugation)|go:"GO:0039595"(induction by virus of catabolism of host mRNA)|go:"GO:0039644"(suppression by virus of host NF-kappaB cascade)|go:"GO:0039648"(modulation by virus of host protein ubiquitination)|go:"GO:0039690"(positive stranded viral RNA replication)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039714"(cytoplasmic viral factory)|go:"GO:0039722"(suppression by virus of host toll-like receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0062243"(double membrane vesicle viral factory outer membrane)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|interpro:IPR002589(Appr-1-p processing)|interpro:IPR008740(Peptidase C30, Coronavirus endopeptidase)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR013016(Peptidase C30/C16)|interpro:IPR014822(Nsp9 replicase)|interpro:IPR014828(Nsp7 replicase)|interpro:IPR014829(Nsp8 replicase)|interpro:IPR018995|interpro:IPR021590|interpro:IPR022733|interpro:IPR024358|interpro:IPR024375|interpro:IPR032505|interpro:IPR032592|interpro:IPR036333|interpro:IPR036499|interpro:IPR037204|interpro:IPR037230|interpro:IPR038030|interpro:IPR038083|interpro:IPR038123|interpro:IPR038166|interpro:IPR038400|interpro:IPR042570|interpro:IPR043177|interpro:IPR043178|interpro:IPR043472|interpro:IPR043477|interpro:IPR043478|interpro:IPR043503|interpro:IPR043504|interpro:IPR043610|interpro:IPR043611|interpro:IPR043612|interpro:IPR043613|interpro:IPR043615|interpro:IPR044353|interpro:IPR044357|interpro:IPR044367|interpro:IPR044371|interpro:IPR044374|interpro:IPR044389|rcsb pdb:1P76|rcsb pdb:1P9T|rcsb pdb:1PA5|rcsb pdb:1PUK|go:"GO:0039604"(suppression by virus of host translation)|rcsb pdb:1Q1X|rcsb pdb:1Q2W|rcsb pdb:1QZ8|rcsb pdb:1UJ1|rcsb pdb:1UK3|rcsb pdb:1UK4|rcsb pdb:1UW7|rcsb pdb:1WOF|rcsb pdb:1YSY|rcsb pdb:1Z1I|rcsb pdb:1Z1J|rcsb pdb:2A5A|rcsb pdb:2A5I|rcsb pdb:2A5K|rcsb pdb:2ACF|rcsb pdb:2AHM|rcsb pdb:2AJ5|rcsb pdb:2ALV|rcsb pdb:2AMD|rcsb pdb:2AMQ|rcsb pdb:2BX3|rcsb pdb:2BX4|rcsb pdb:2C3S|rcsb pdb:2D2D|rcsb pdb:2DUC|rcsb pdb:2FAV|rcsb pdb:2FE8|rcsb pdb:2FYG|rcsb pdb:2G9T|rcsb pdb:2GA6|rcsb pdb:2GDT|rcsb pdb:2GRI|rcsb pdb:2GT7|rcsb pdb:2GT8|rcsb pdb:2GTB|rcsb pdb:2GX4|rcsb pdb:2GZ7|rcsb pdb:2GZ8|rcsb pdb:2GZ9|rcsb pdb:2H2Z|rcsb pdb:2HOB|rcsb pdb:2HSX|rcsb pdb:2IDY|rcsb pdb:2KAF|rcsb pdb:2KQV|rcsb pdb:2KQW|rcsb pdb:2KYS|rcsb pdb:2LIZ|rcsb pdb:2OP9|rcsb pdb:2PWX|rcsb pdb:2W2G|rcsb pdb:2WCT|rcsb pdb:2Z3C|rcsb pdb:2Z3D|rcsb pdb:2Z3E|rcsb pdb:2ZU4|rcsb pdb:2ZU5|rcsb pdb:3ATW|rcsb pdb:3AVZ|rcsb pdb:3AW0|rcsb pdb:3AW1|rcsb pdb:3E91|rcsb pdb:3EA7|rcsb pdb:3EA8|rcsb pdb:3EA9|rcsb pdb:3EAJ|rcsb pdb:3EE7|rcsb pdb:3F9E|rcsb pdb:3F9F|rcsb pdb:3F9G|rcsb pdb:3F9H|rcsb pdb:3FZD|rcsb pdb:3IWM|rcsb pdb:3M3S|rcsb pdb:3M3T|rcsb pdb:3M3V|rcsb pdb:3MJ5|rcsb pdb:3R24|rcsb pdb:3SN8|rcsb pdb:3SNA|rcsb pdb:3SNB|rcsb pdb:3SNC|rcsb pdb:3SND|rcsb pdb:3SNE|rcsb pdb:1UK2|rcsb pdb:3SZN|rcsb pdb:3TIT|rcsb pdb:3TIU|rcsb pdb:3TNS|rcsb pdb:3TNT|rcsb pdb:3V3M|rcsb pdb:3VB3|rcsb pdb:3VB4|rcsb pdb:3VB5|rcsb pdb:3VB6|rcsb pdb:3VB7|rcsb pdb:4HI3|rcsb pdb:4M0W|rcsb pdb:4MDS|rcsb pdb:4MM3|rcsb pdb:4OVZ|rcsb pdb:4OW0|rcsb pdb:5F22|rcsb pdb:5Y3E|rcsb pdb:5Y3Q|rcsb pdb:6LNY|rcsb pdb:6NUR|rcsb pdb:6NUS|rcsb pdb:6W2A|rcsb pdb:6XHL|rcsb pdb:6XHN|rcsb pdb:6XHO|rcsb pdb:6Y7M|rcsb pdb:6YXJ|rcsb pdb:6LO0|reactome:R-HSA-9679504|reactome:R-HSA-9682706|reactome:R-HSA-9682708|reactome:R-HSA-9683439|reactome:R-HSA-9684325|dip:DIP-48580N	go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019079"(viral genome replication)|go:"GO:0019082"(viral protein processing)|go:"GO:0019083"(viral transcription)|go:"GO:0019785"(ISG15-specific protease activity)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039501"(suppression by virus of host type I interferon production)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039519"(modulation by virus of host autophagy)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039547"(suppression by virus of host TRAF activity)|go:"GO:0039548"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity)|go:"GO:0039579"(suppression by virus of host ISG15-protein conjugation)|go:"GO:0039595"(induction by virus of catabolism of host mRNA)|go:"GO:0039644"(suppression by virus of host NF-kappaB cascade)|go:"GO:0039648"(modulation by virus of host protein ubiquitination)|go:"GO:0039690"(positive stranded viral RNA replication)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039714"(cytoplasmic viral factory)|go:"GO:0039722"(suppression by virus of host toll-like receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0062243"(double membrane vesicle viral factory outer membrane)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|interpro:IPR002589(Appr-1-p processing)|interpro:IPR008740(Peptidase C30, Coronavirus endopeptidase)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR013016(Peptidase C30/C16)|interpro:IPR014822(Nsp9 replicase)|interpro:IPR014828(Nsp7 replicase)|interpro:IPR014829(Nsp8 replicase)|interpro:IPR018995|interpro:IPR021590|interpro:IPR022733|interpro:IPR024358|interpro:IPR024375|interpro:IPR032505|interpro:IPR032592|interpro:IPR036333|interpro:IPR036499|interpro:IPR037204|interpro:IPR037230|interpro:IPR038030|interpro:IPR038083|interpro:IPR038123|interpro:IPR038166|interpro:IPR038400|interpro:IPR042570|interpro:IPR043177|interpro:IPR043178|interpro:IPR043472|interpro:IPR043477|interpro:IPR043478|interpro:IPR043503|interpro:IPR043504|interpro:IPR043610|interpro:IPR043611|interpro:IPR043612|interpro:IPR043613|interpro:IPR043615|interpro:IPR044353|interpro:IPR044357|interpro:IPR044367|interpro:IPR044371|interpro:IPR044374|interpro:IPR044389|rcsb pdb:1P76|rcsb pdb:1P9T|rcsb pdb:1PA5|rcsb pdb:1PUK|go:"GO:0039604"(suppression by virus of host translation)|rcsb pdb:1Q1X|rcsb pdb:1Q2W|rcsb pdb:1QZ8|rcsb pdb:1UJ1|rcsb pdb:1UK3|rcsb pdb:1UK4|rcsb pdb:1UW7|rcsb pdb:1WOF|rcsb pdb:1YSY|rcsb pdb:1Z1I|rcsb pdb:1Z1J|rcsb pdb:2A5A|rcsb pdb:2A5I|rcsb pdb:2A5K|rcsb pdb:2ACF|rcsb pdb:2AHM|rcsb pdb:2AJ5|rcsb pdb:2ALV|rcsb pdb:2AMD|rcsb pdb:2AMQ|rcsb pdb:2BX3|rcsb pdb:2BX4|rcsb pdb:2C3S|rcsb pdb:2D2D|rcsb pdb:2DUC|rcsb pdb:2FAV|rcsb pdb:2FE8|rcsb pdb:2FYG|rcsb pdb:2G9T|rcsb pdb:2GA6|rcsb pdb:2GDT|rcsb pdb:2GRI|rcsb pdb:2GT7|rcsb pdb:2GT8|rcsb pdb:2GTB|rcsb pdb:2GX4|rcsb pdb:2GZ7|rcsb pdb:2GZ8|rcsb pdb:2GZ9|rcsb pdb:2H2Z|rcsb pdb:2HOB|rcsb pdb:2HSX|rcsb pdb:2IDY|rcsb pdb:2KAF|rcsb pdb:2KQV|rcsb pdb:2KQW|rcsb pdb:2KYS|rcsb pdb:2LIZ|rcsb pdb:2OP9|rcsb pdb:2PWX|rcsb pdb:2W2G|rcsb pdb:2WCT|rcsb pdb:2Z3C|rcsb pdb:2Z3D|rcsb pdb:2Z3E|rcsb pdb:2ZU4|rcsb pdb:2ZU5|rcsb pdb:3ATW|rcsb pdb:3AVZ|rcsb pdb:3AW0|rcsb pdb:3AW1|rcsb pdb:3E91|rcsb pdb:3EA7|rcsb pdb:3EA8|rcsb pdb:3EA9|rcsb pdb:3EAJ|rcsb pdb:3EE7|rcsb pdb:3F9E|rcsb pdb:3F9F|rcsb pdb:3F9G|rcsb pdb:3F9H|rcsb pdb:3FZD|rcsb pdb:3IWM|rcsb pdb:3M3S|rcsb pdb:3M3T|rcsb pdb:3M3V|rcsb pdb:3MJ5|rcsb pdb:3R24|rcsb pdb:3SN8|rcsb pdb:3SNA|rcsb pdb:3SNB|rcsb pdb:3SNC|rcsb pdb:3SND|rcsb pdb:3SNE|rcsb pdb:1UK2|rcsb pdb:3SZN|rcsb pdb:3TIT|rcsb pdb:3TIU|rcsb pdb:3TNS|rcsb pdb:3TNT|rcsb pdb:3V3M|rcsb pdb:3VB3|rcsb pdb:3VB4|rcsb pdb:3VB5|rcsb pdb:3VB6|rcsb pdb:3VB7|rcsb pdb:4HI3|rcsb pdb:4M0W|rcsb pdb:4MDS|rcsb pdb:4MM3|rcsb pdb:4OVZ|rcsb pdb:4OW0|rcsb pdb:5F22|rcsb pdb:5Y3E|rcsb pdb:5Y3Q|rcsb pdb:6LNY|rcsb pdb:6NUR|rcsb pdb:6NUS|rcsb pdb:6W2A|rcsb pdb:6XHL|rcsb pdb:6XHN|rcsb pdb:6XHO|rcsb pdb:6Y7M|rcsb pdb:6YXJ|rcsb pdb:6LO0|reactome:R-HSA-9679504|reactome:R-HSA-9682706|reactome:R-HSA-9682708|reactome:R-HSA-9683439|reactome:R-HSA-9684325|dip:DIP-48580N	-	-	-	figure legend:Figs. 2a-e, S4-7, S4-8|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/04/21	2020/05/18	rogid:zwPSRRjRlqC4IBqawJVQzY4HMGs694009	rogid:zwPSRRjRlqC4IBqawJVQzY4HMGs694009	rigid:HMwPu9Xqpte8SlLRFljXrZoq5BQ	false	sufficient binding region:3241-3556|mutation decreasing interaction rate:3546-3546|mutation decreasing interaction rate:3545-3545,3546-3546	mutation:3545-3545|mutation:3545-3545,3549-3549|mutation:3545-3545,3549-3549|green fluorescent protein tag:?-?|sufficient binding region:3527-3556,3231-3250|s tag:n-n|his tag:c-c|mutation:3549-3549|mutation:3549-3549|mutation:3243-3243|mutation:3243-3243	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:P0C6U8	uniprotkb:P0C6U8	intact:EBI-15810860|uniprotkb:P59641	intact:EBI-15810860|uniprotkb:P59641	psi-mi:r1a_sars(display_long)|uniprotkb:ORF1a polyprotein(gene name synonym)|uniprotkb:1a(orf name)	psi-mi:r1a_sars(display_long)|uniprotkb:ORF1a polyprotein(gene name synonym)|uniprotkb:1a(orf name)	psi-mi:"MI:0435"(protease assay)	Muramatsu et al. (2016)	pubmed:27799534|imex:IM-27932	taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus)	taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25595622|imex:IM-27932-25	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019079"(viral genome replication)|go:"GO:0019082"(viral protein processing)|go:"GO:0019083"(viral transcription)|go:"GO:0019785"(ISG15-specific protease activity)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039501"(suppression by virus of host type I interferon production)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039519"(modulation by virus of host autophagy)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039547"(suppression by virus of host TRAF activity)|go:"GO:0039548"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity)|go:"GO:0039579"(suppression by virus of host ISG15-protein conjugation)|go:"GO:0039595"(induction by virus of catabolism of host mRNA)|go:"GO:0039644"(suppression by virus of host NF-kappaB cascade)|go:"GO:0039648"(modulation by virus of host protein ubiquitination)|go:"GO:0039690"(positive stranded viral RNA replication)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039714"(cytoplasmic viral factory)|go:"GO:0039722"(suppression by virus of host toll-like receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0062243"(double membrane vesicle viral factory outer membrane)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|interpro:IPR002589(Appr-1-p processing)|interpro:IPR008740(Peptidase C30, Coronavirus endopeptidase)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR013016(Peptidase C30/C16)|interpro:IPR014822(Nsp9 replicase)|interpro:IPR014828(Nsp7 replicase)|interpro:IPR014829(Nsp8 replicase)|interpro:IPR018995|interpro:IPR021590|interpro:IPR022733|interpro:IPR024358|interpro:IPR024375|interpro:IPR032505|interpro:IPR032592|interpro:IPR036333|interpro:IPR036499|interpro:IPR037204|interpro:IPR037230|interpro:IPR038030|interpro:IPR038083|interpro:IPR038123|interpro:IPR038166|interpro:IPR038400|interpro:IPR042570|interpro:IPR043177|interpro:IPR043178|interpro:IPR043472|interpro:IPR043477|interpro:IPR043478|interpro:IPR043503|interpro:IPR043504|interpro:IPR043610|interpro:IPR043611|interpro:IPR043612|interpro:IPR043613|interpro:IPR043615|interpro:IPR044353|interpro:IPR044357|interpro:IPR044367|interpro:IPR044371|interpro:IPR044374|interpro:IPR044389|rcsb pdb:1P76|rcsb pdb:1P9T|rcsb pdb:1PA5|rcsb pdb:1PUK|go:"GO:0039604"(suppression by virus of host translation)|rcsb pdb:1Q1X|rcsb pdb:1Q2W|rcsb pdb:1QZ8|rcsb pdb:1UJ1|rcsb pdb:1UK3|rcsb pdb:1UK4|rcsb pdb:1UW7|rcsb pdb:1WOF|rcsb pdb:1YSY|rcsb pdb:1Z1I|rcsb pdb:1Z1J|rcsb pdb:2A5A|rcsb pdb:2A5I|rcsb pdb:2A5K|rcsb pdb:2ACF|rcsb pdb:2AHM|rcsb pdb:2AJ5|rcsb pdb:2ALV|rcsb pdb:2AMD|rcsb pdb:2AMQ|rcsb pdb:2BX3|rcsb pdb:2BX4|rcsb pdb:2C3S|rcsb pdb:2D2D|rcsb pdb:2DUC|rcsb pdb:2FAV|rcsb pdb:2FE8|rcsb pdb:2FYG|rcsb pdb:2G9T|rcsb pdb:2GA6|rcsb pdb:2GDT|rcsb pdb:2GRI|rcsb pdb:2GT7|rcsb pdb:2GT8|rcsb pdb:2GTB|rcsb pdb:2GX4|rcsb pdb:2GZ7|rcsb pdb:2GZ8|rcsb pdb:2GZ9|rcsb pdb:2H2Z|rcsb pdb:2HOB|rcsb pdb:2HSX|rcsb pdb:2IDY|rcsb pdb:2KAF|rcsb pdb:2KQV|rcsb pdb:2KQW|rcsb pdb:2KYS|rcsb pdb:2LIZ|rcsb pdb:2OP9|rcsb pdb:2PWX|rcsb pdb:2W2G|rcsb pdb:2WCT|rcsb pdb:2Z3C|rcsb pdb:2Z3D|rcsb pdb:2Z3E|rcsb pdb:2ZU4|rcsb pdb:2ZU5|rcsb pdb:3ATW|rcsb pdb:3AVZ|rcsb pdb:3AW0|rcsb pdb:3AW1|rcsb pdb:3E91|rcsb pdb:3EA7|rcsb pdb:3EA8|rcsb pdb:3EA9|rcsb pdb:3EAJ|rcsb pdb:3EE7|rcsb pdb:3F9E|rcsb pdb:3F9F|rcsb pdb:3F9G|rcsb pdb:3F9H|rcsb pdb:3FZD|rcsb pdb:3IWM|rcsb pdb:3M3S|rcsb pdb:3M3T|rcsb pdb:3M3V|rcsb pdb:3MJ5|rcsb pdb:3R24|rcsb pdb:3SN8|rcsb pdb:3SNA|rcsb pdb:3SNB|rcsb pdb:3SNC|rcsb pdb:3SND|rcsb pdb:3SNE|rcsb pdb:1UK2|rcsb pdb:3SZN|rcsb pdb:3TIT|rcsb pdb:3TIU|rcsb pdb:3TNS|rcsb pdb:3TNT|rcsb pdb:3V3M|rcsb pdb:3VB3|rcsb pdb:3VB4|rcsb pdb:3VB5|rcsb pdb:3VB6|rcsb pdb:3VB7|rcsb pdb:4HI3|rcsb pdb:4M0W|rcsb pdb:4MDS|rcsb pdb:4MM3|rcsb pdb:4OVZ|rcsb pdb:4OW0|rcsb pdb:5F22|rcsb pdb:5Y3E|rcsb pdb:5Y3Q|rcsb pdb:6LNY|rcsb pdb:6NUR|rcsb pdb:6NUS|rcsb pdb:6W2A|rcsb pdb:6XHL|rcsb pdb:6XHN|rcsb pdb:6XHO|rcsb pdb:6Y7M|rcsb pdb:6YXJ|rcsb pdb:6LO0|reactome:R-HSA-9679504|reactome:R-HSA-9682706|reactome:R-HSA-9682708|reactome:R-HSA-9683439|reactome:R-HSA-9684325|dip:DIP-48580N	go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019079"(viral genome replication)|go:"GO:0019082"(viral protein processing)|go:"GO:0019083"(viral transcription)|go:"GO:0019785"(ISG15-specific protease activity)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039501"(suppression by virus of host type I interferon production)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039519"(modulation by virus of host autophagy)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039547"(suppression by virus of host TRAF activity)|go:"GO:0039548"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity)|go:"GO:0039579"(suppression by virus of host ISG15-protein conjugation)|go:"GO:0039595"(induction by virus of catabolism of host mRNA)|go:"GO:0039644"(suppression by virus of host NF-kappaB cascade)|go:"GO:0039648"(modulation by virus of host protein ubiquitination)|go:"GO:0039690"(positive stranded viral RNA replication)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039714"(cytoplasmic viral factory)|go:"GO:0039722"(suppression by virus of host toll-like receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0062243"(double membrane vesicle viral factory outer membrane)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|interpro:IPR002589(Appr-1-p processing)|interpro:IPR008740(Peptidase C30, Coronavirus endopeptidase)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR013016(Peptidase C30/C16)|interpro:IPR014822(Nsp9 replicase)|interpro:IPR014828(Nsp7 replicase)|interpro:IPR014829(Nsp8 replicase)|interpro:IPR018995|interpro:IPR021590|interpro:IPR022733|interpro:IPR024358|interpro:IPR024375|interpro:IPR032505|interpro:IPR032592|interpro:IPR036333|interpro:IPR036499|interpro:IPR037204|interpro:IPR037230|interpro:IPR038030|interpro:IPR038083|interpro:IPR038123|interpro:IPR038166|interpro:IPR038400|interpro:IPR042570|interpro:IPR043177|interpro:IPR043178|interpro:IPR043472|interpro:IPR043477|interpro:IPR043478|interpro:IPR043503|interpro:IPR043504|interpro:IPR043610|interpro:IPR043611|interpro:IPR043612|interpro:IPR043613|interpro:IPR043615|interpro:IPR044353|interpro:IPR044357|interpro:IPR044367|interpro:IPR044371|interpro:IPR044374|interpro:IPR044389|rcsb pdb:1P76|rcsb pdb:1P9T|rcsb pdb:1PA5|rcsb pdb:1PUK|go:"GO:0039604"(suppression by virus of host translation)|rcsb pdb:1Q1X|rcsb pdb:1Q2W|rcsb pdb:1QZ8|rcsb pdb:1UJ1|rcsb pdb:1UK3|rcsb pdb:1UK4|rcsb pdb:1UW7|rcsb pdb:1WOF|rcsb pdb:1YSY|rcsb pdb:1Z1I|rcsb pdb:1Z1J|rcsb pdb:2A5A|rcsb pdb:2A5I|rcsb pdb:2A5K|rcsb pdb:2ACF|rcsb pdb:2AHM|rcsb pdb:2AJ5|rcsb pdb:2ALV|rcsb pdb:2AMD|rcsb pdb:2AMQ|rcsb pdb:2BX3|rcsb pdb:2BX4|rcsb pdb:2C3S|rcsb pdb:2D2D|rcsb pdb:2DUC|rcsb pdb:2FAV|rcsb pdb:2FE8|rcsb pdb:2FYG|rcsb pdb:2G9T|rcsb pdb:2GA6|rcsb pdb:2GDT|rcsb pdb:2GRI|rcsb pdb:2GT7|rcsb pdb:2GT8|rcsb pdb:2GTB|rcsb pdb:2GX4|rcsb pdb:2GZ7|rcsb pdb:2GZ8|rcsb pdb:2GZ9|rcsb pdb:2H2Z|rcsb pdb:2HOB|rcsb pdb:2HSX|rcsb pdb:2IDY|rcsb pdb:2KAF|rcsb pdb:2KQV|rcsb pdb:2KQW|rcsb pdb:2KYS|rcsb pdb:2LIZ|rcsb pdb:2OP9|rcsb pdb:2PWX|rcsb pdb:2W2G|rcsb pdb:2WCT|rcsb pdb:2Z3C|rcsb pdb:2Z3D|rcsb pdb:2Z3E|rcsb pdb:2ZU4|rcsb pdb:2ZU5|rcsb pdb:3ATW|rcsb pdb:3AVZ|rcsb pdb:3AW0|rcsb pdb:3AW1|rcsb pdb:3E91|rcsb pdb:3EA7|rcsb pdb:3EA8|rcsb pdb:3EA9|rcsb pdb:3EAJ|rcsb pdb:3EE7|rcsb pdb:3F9E|rcsb pdb:3F9F|rcsb pdb:3F9G|rcsb pdb:3F9H|rcsb pdb:3FZD|rcsb pdb:3IWM|rcsb pdb:3M3S|rcsb pdb:3M3T|rcsb pdb:3M3V|rcsb pdb:3MJ5|rcsb pdb:3R24|rcsb pdb:3SN8|rcsb pdb:3SNA|rcsb pdb:3SNB|rcsb pdb:3SNC|rcsb pdb:3SND|rcsb pdb:3SNE|rcsb pdb:1UK2|rcsb pdb:3SZN|rcsb pdb:3TIT|rcsb pdb:3TIU|rcsb pdb:3TNS|rcsb pdb:3TNT|rcsb pdb:3V3M|rcsb pdb:3VB3|rcsb pdb:3VB4|rcsb pdb:3VB5|rcsb pdb:3VB6|rcsb pdb:3VB7|rcsb pdb:4HI3|rcsb pdb:4M0W|rcsb pdb:4MDS|rcsb pdb:4MM3|rcsb pdb:4OVZ|rcsb pdb:4OW0|rcsb pdb:5F22|rcsb pdb:5Y3E|rcsb pdb:5Y3Q|rcsb pdb:6LNY|rcsb pdb:6NUR|rcsb pdb:6NUS|rcsb pdb:6W2A|rcsb pdb:6XHL|rcsb pdb:6XHN|rcsb pdb:6XHO|rcsb pdb:6Y7M|rcsb pdb:6YXJ|rcsb pdb:6LO0|reactome:R-HSA-9679504|reactome:R-HSA-9682706|reactome:R-HSA-9682708|reactome:R-HSA-9683439|reactome:R-HSA-9684325|dip:DIP-48580N	-	-	-	figure legend:Fig. S4-0|comment:"Cys3385Ala (C145A) is a cleavage-defective active-site mutation"|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/04/21	2020/05/18	rogid:zwPSRRjRlqC4IBqawJVQzY4HMGs694009	rogid:zwPSRRjRlqC4IBqawJVQzY4HMGs694009	rigid:HMwPu9Xqpte8SlLRFljXrZoq5BQ	false	green fluorescent protein tag:?-?|sufficient binding region:3527-3556,3231-3250|s tag:n-n|his tag:c-c	s tag:n-n|sufficient binding region:3231-3556|his tag:c-c|mutation disrupting interaction rate:3385-3385	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)