#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P14679	uniprotkb:P51810	intact:EBI-25397340|ensembl:ENSP00000263321|uniprotkb:Q15675|uniprotkb:Q15676|uniprotkb:Q15680|uniprotkb:Q8TAK4|uniprotkb:Q9BYY0|uniprotkb:Q9BZX1	intact:EBI-2509708|ensembl:ENSP00000417161|uniprotkb:Q6NTI7	psi-mi:tyro_human(display_long)|uniprotkb:LB24-AB(gene name synonym)|uniprotkb:Monophenol monooxygenase(gene name synonym)|uniprotkb:SK29-AB(gene name synonym)|uniprotkb:Tumor rejection antigen AB(gene name synonym)|uniprotkb:TYR(gene name)|psi-mi:TYR(display_short)	psi-mi:gp143_human(display_long)|uniprotkb:GPR143(gene name)|psi-mi:GPR143(display_short)|uniprotkb:OA1(gene name synonym)|uniprotkb:Ocular albinism type 1 protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	De et al. (2017)	pubmed:27720922|imex:IM-27642	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25397381|imex:IM-27642-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043473"(pigmentation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048538"(thymus development)|go:"GO:0051591"(response to cAMP)|interpro:IPR002227(Tyrosinase)|interpro:IPR008922(Di-copper centre-containing)|reactome:R-HSA-5662702|ensembl:ENSG00000077498(gene)|ensembl:ENST00000263321(transcript)|go:"GO:0004503"(tyrosinase activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005829"(cytosol)|go:"GO:0006583"(melanin biosynthetic process from tyrosine)|go:"GO:0006726"(eye pigment biosynthetic process)|go:"GO:0007601"(visual perception)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009411"(response to UV)|go:"GO:0009637"(response to blue light)|go:"GO:0016021"(integral component of membrane)|go:"GO:0033162"(melanosome membrane)|go:"GO:0033280"(response to vitamin D)|go:"GO:0042438"(melanin biosynthetic process)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|refseq:NP_000363.1	go:"GO:0007186"(G protein-coupled receptor signaling pathway)|ensembl:ENSG00000101850(gene)|go:"GO:0007601"(visual perception)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|ensembl:ENST00000467482(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0032400"(melanosome localization)|go:"GO:0032402"(melanosome transport)|go:"GO:0032438"(melanosome organization)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0033162"(melanosome membrane)|go:"GO:0035240"(dopamine binding)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005886"(plasma membrane)|go:"GO:0035643"(L-DOPA receptor activity)|go:"GO:0042470"(melanosome)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0050848"(regulation of calcium-mediated signaling)|go:"GO:0006726"(eye pigment biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0072544"(L-DOPA binding)|go:"GO:0072545"(tyrosine binding)|interpro:IPR001414(Ocular albinism protein, type 1)|reactome:R-HSA-375280|reactome:R-HSA-416476|refseq:NP_000264.2|dip:DIP-53284N	-	-	-	figure legend:2a, S2|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2020/01/14	2020/01/14	rogid:uCwNyknCSUxNSdTD5/IR/+E2dro9606	rogid:5MujRgqKPE16sLr4bggbtISx2Io9606	rigid:6xTfqn5mJpahO+3+cF0Te9lTjT0	false	enhanced green fluorescent protein tag:?-?	mutation with no effect:223-224,329-330|tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P14679	uniprotkb:P51810	intact:EBI-25397340|ensembl:ENSP00000263321|uniprotkb:Q15675|uniprotkb:Q15676|uniprotkb:Q15680|uniprotkb:Q8TAK4|uniprotkb:Q9BYY0|uniprotkb:Q9BZX1	intact:EBI-2509708|ensembl:ENSP00000417161|uniprotkb:Q6NTI7	psi-mi:tyro_human(display_long)|uniprotkb:LB24-AB(gene name synonym)|uniprotkb:Monophenol monooxygenase(gene name synonym)|uniprotkb:SK29-AB(gene name synonym)|uniprotkb:Tumor rejection antigen AB(gene name synonym)|uniprotkb:TYR(gene name)|psi-mi:TYR(display_short)	psi-mi:gp143_human(display_long)|uniprotkb:GPR143(gene name)|psi-mi:GPR143(display_short)|uniprotkb:OA1(gene name synonym)|uniprotkb:Ocular albinism type 1 protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	De et al. (2017)	pubmed:27720922|imex:IM-27642	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25397419|imex:IM-27642-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043473"(pigmentation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048538"(thymus development)|go:"GO:0051591"(response to cAMP)|interpro:IPR002227(Tyrosinase)|interpro:IPR008922(Di-copper centre-containing)|reactome:R-HSA-5662702|ensembl:ENSG00000077498(gene)|ensembl:ENST00000263321(transcript)|go:"GO:0004503"(tyrosinase activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005829"(cytosol)|go:"GO:0006583"(melanin biosynthetic process from tyrosine)|go:"GO:0006726"(eye pigment biosynthetic process)|go:"GO:0007601"(visual perception)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009411"(response to UV)|go:"GO:0009637"(response to blue light)|go:"GO:0016021"(integral component of membrane)|go:"GO:0033162"(melanosome membrane)|go:"GO:0033280"(response to vitamin D)|go:"GO:0042438"(melanin biosynthetic process)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|refseq:NP_000363.1	go:"GO:0007186"(G protein-coupled receptor signaling pathway)|ensembl:ENSG00000101850(gene)|go:"GO:0007601"(visual perception)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|ensembl:ENST00000467482(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0032400"(melanosome localization)|go:"GO:0032402"(melanosome transport)|go:"GO:0032438"(melanosome organization)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0033162"(melanosome membrane)|go:"GO:0035240"(dopamine binding)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005886"(plasma membrane)|go:"GO:0035643"(L-DOPA receptor activity)|go:"GO:0042470"(melanosome)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0050848"(regulation of calcium-mediated signaling)|go:"GO:0006726"(eye pigment biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0072544"(L-DOPA binding)|go:"GO:0072545"(tyrosine binding)|interpro:IPR001414(Ocular albinism protein, type 1)|reactome:R-HSA-375280|reactome:R-HSA-416476|refseq:NP_000264.2|dip:DIP-53284N	-	-	-	figure legend:S3|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2020/01/14	2020/01/14	rogid:uCwNyknCSUxNSdTD5/IR/+E2dro9606	rogid:5MujRgqKPE16sLr4bggbtISx2Io9606	rigid:6xTfqn5mJpahO+3+cF0Te9lTjT0	false	enhanced green fluorescent protein tag:?-?	tag:?-?|mutation with no effect:223-224,329-330	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P51810	uniprotkb:P11344	intact:EBI-2509708|ensembl:ENSP00000417161|uniprotkb:Q6NTI7	intact:EBI-821603|ensembl:ENSMUSP00000004770	psi-mi:gp143_human(display_long)|uniprotkb:GPR143(gene name)|psi-mi:GPR143(display_short)|uniprotkb:OA1(gene name synonym)|uniprotkb:Ocular albinism type 1 protein(gene name synonym)	psi-mi:tyro_mouse(display_long)|uniprotkb:Monophenol monooxygenase(gene name synonym)|uniprotkb:Albino locus protein(gene name synonym)|uniprotkb:Tyr(gene name)|psi-mi:Tyr(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	De et al. (2017)	pubmed:27720922|imex:IM-27642	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25397401|imex:IM-27642-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007186"(G protein-coupled receptor signaling pathway)|ensembl:ENSG00000101850(gene)|go:"GO:0007601"(visual perception)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|ensembl:ENST00000467482(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0032400"(melanosome localization)|go:"GO:0032402"(melanosome transport)|go:"GO:0032438"(melanosome organization)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0033162"(melanosome membrane)|go:"GO:0035240"(dopamine binding)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005886"(plasma membrane)|go:"GO:0035643"(L-DOPA receptor activity)|go:"GO:0042470"(melanosome)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0050848"(regulation of calcium-mediated signaling)|go:"GO:0006726"(eye pigment biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0072544"(L-DOPA binding)|go:"GO:0072545"(tyrosine binding)|interpro:IPR001414(Ocular albinism protein, type 1)|reactome:R-HSA-375280|reactome:R-HSA-416476|refseq:NP_000264.2|dip:DIP-53284N	refseq:NP_035791.1|ensembl:ENSMUSG00000004651(gene)|ensembl:ENSMUST00000004770(transcript)|go:"GO:0004503"(tyrosinase activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009411"(response to UV)|go:"GO:0009637"(response to blue light)|go:"GO:0016021"(integral component of membrane)|go:"GO:0033162"(melanosome membrane)|go:"GO:0033280"(response to vitamin D)|go:"GO:0042438"(melanin biosynthetic process)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043473"(pigmentation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048538"(thymus development)|go:"GO:0051591"(response to cAMP)|interpro:IPR002227(Tyrosinase)|interpro:IPR008922(Di-copper centre-containing)|reactome:R-MMU-5662702	-	-	-	figure legend:2b, S4|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-melan-a)|taxid:10090(Mouse melan-a - immortalised melanocyte cell  line)	-	2020/01/14	2020/01/24	rogid:5MujRgqKPE16sLr4bggbtISx2Io9606	rogid:RELxPvWYI7PD9JFDdMOVmQfJ54810090	rigid:PDtL+dFJXgS88Mfd3Jzu1wP5wmE	false	enhanced green fluorescent protein tag:?-?|mutation with no effect:223-224,329-330	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P14679	uniprotkb:P51810	intact:EBI-25397340|ensembl:ENSP00000263321|uniprotkb:Q15675|uniprotkb:Q15676|uniprotkb:Q15680|uniprotkb:Q8TAK4|uniprotkb:Q9BYY0|uniprotkb:Q9BZX1	intact:EBI-2509708|ensembl:ENSP00000417161|uniprotkb:Q6NTI7	psi-mi:tyro_human(display_long)|uniprotkb:LB24-AB(gene name synonym)|uniprotkb:Monophenol monooxygenase(gene name synonym)|uniprotkb:SK29-AB(gene name synonym)|uniprotkb:Tumor rejection antigen AB(gene name synonym)|uniprotkb:TYR(gene name)|psi-mi:TYR(display_short)	psi-mi:gp143_human(display_long)|uniprotkb:GPR143(gene name)|psi-mi:GPR143(display_short)|uniprotkb:OA1(gene name synonym)|uniprotkb:Ocular albinism type 1 protein(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	De et al. (2017)	pubmed:27720922|imex:IM-27642	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25397437|imex:IM-27642-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043473"(pigmentation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048538"(thymus development)|go:"GO:0051591"(response to cAMP)|interpro:IPR002227(Tyrosinase)|interpro:IPR008922(Di-copper centre-containing)|reactome:R-HSA-5662702|ensembl:ENSG00000077498(gene)|ensembl:ENST00000263321(transcript)|go:"GO:0004503"(tyrosinase activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005829"(cytosol)|go:"GO:0006583"(melanin biosynthetic process from tyrosine)|go:"GO:0006726"(eye pigment biosynthetic process)|go:"GO:0007601"(visual perception)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009411"(response to UV)|go:"GO:0009637"(response to blue light)|go:"GO:0016021"(integral component of membrane)|go:"GO:0033162"(melanosome membrane)|go:"GO:0033280"(response to vitamin D)|go:"GO:0042438"(melanin biosynthetic process)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|refseq:NP_000363.1	go:"GO:0007186"(G protein-coupled receptor signaling pathway)|ensembl:ENSG00000101850(gene)|go:"GO:0007601"(visual perception)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|ensembl:ENST00000467482(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0032400"(melanosome localization)|go:"GO:0032402"(melanosome transport)|go:"GO:0032438"(melanosome organization)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0033162"(melanosome membrane)|go:"GO:0035240"(dopamine binding)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005886"(plasma membrane)|go:"GO:0035643"(L-DOPA receptor activity)|go:"GO:0042470"(melanosome)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0050848"(regulation of calcium-mediated signaling)|go:"GO:0006726"(eye pigment biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0072544"(L-DOPA binding)|go:"GO:0072545"(tyrosine binding)|interpro:IPR001414(Ocular albinism protein, type 1)|reactome:R-HSA-375280|reactome:R-HSA-416476|refseq:NP_000264.2|dip:DIP-53284N	go:"GO:0048471"(perinuclear region of cytoplasm)	-	-	figure legend:3a|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2020/01/14	2020/01/14	rogid:uCwNyknCSUxNSdTD5/IR/+E2dro9606	rogid:5MujRgqKPE16sLr4bggbtISx2Io9606	rigid:6xTfqn5mJpahO+3+cF0Te9lTjT0	false	enhanced green fluorescent protein tag:?-?	tag:?-?|mutation with no effect:223-224,329-330	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P11344	uniprotkb:P51810	intact:EBI-821603|ensembl:ENSMUSP00000004770	intact:EBI-2509708|ensembl:ENSP00000417161|uniprotkb:Q6NTI7	psi-mi:tyro_mouse(display_long)|uniprotkb:Monophenol monooxygenase(gene name synonym)|uniprotkb:Albino locus protein(gene name synonym)|uniprotkb:Tyr(gene name)|psi-mi:Tyr(display_short)	psi-mi:gp143_human(display_long)|uniprotkb:GPR143(gene name)|psi-mi:GPR143(display_short)|uniprotkb:OA1(gene name synonym)|uniprotkb:Ocular albinism type 1 protein(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	De et al. (2017)	pubmed:27720922|imex:IM-27642	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25397460|imex:IM-27642-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035791.1|ensembl:ENSMUSG00000004651(gene)|ensembl:ENSMUST00000004770(transcript)|go:"GO:0004503"(tyrosinase activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009411"(response to UV)|go:"GO:0009637"(response to blue light)|go:"GO:0016021"(integral component of membrane)|go:"GO:0033162"(melanosome membrane)|go:"GO:0033280"(response to vitamin D)|go:"GO:0042438"(melanin biosynthetic process)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043473"(pigmentation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048538"(thymus development)|go:"GO:0051591"(response to cAMP)|interpro:IPR002227(Tyrosinase)|interpro:IPR008922(Di-copper centre-containing)|reactome:R-MMU-5662702	go:"GO:0007186"(G protein-coupled receptor signaling pathway)|ensembl:ENSG00000101850(gene)|go:"GO:0007601"(visual perception)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|ensembl:ENST00000467482(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0032400"(melanosome localization)|go:"GO:0032402"(melanosome transport)|go:"GO:0032438"(melanosome organization)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0033162"(melanosome membrane)|go:"GO:0035240"(dopamine binding)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005886"(plasma membrane)|go:"GO:0035643"(L-DOPA receptor activity)|go:"GO:0042470"(melanosome)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0050848"(regulation of calcium-mediated signaling)|go:"GO:0006726"(eye pigment biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0072544"(L-DOPA binding)|go:"GO:0072545"(tyrosine binding)|interpro:IPR001414(Ocular albinism protein, type 1)|reactome:R-HSA-375280|reactome:R-HSA-416476|refseq:NP_000264.2|dip:DIP-53284N	-	-	-	figure legend:3b|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-melan-a)|taxid:10090(Mouse melan-a - immortalised melanocyte cell  line)	-	2020/01/14	2020/01/14	rogid:RELxPvWYI7PD9JFDdMOVmQfJ54810090	rogid:5MujRgqKPE16sLr4bggbtISx2Io9606	rigid:PDtL+dFJXgS88Mfd3Jzu1wP5wmE	false	-	enhanced yellow fluorescent protein tag:?-?	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P51810	uniprotkb:P14679	intact:EBI-2509708|ensembl:ENSP00000417161|uniprotkb:Q6NTI7	intact:EBI-25397340|ensembl:ENSP00000263321|uniprotkb:Q15675|uniprotkb:Q15676|uniprotkb:Q15680|uniprotkb:Q8TAK4|uniprotkb:Q9BYY0|uniprotkb:Q9BZX1	psi-mi:gp143_human(display_long)|uniprotkb:GPR143(gene name)|psi-mi:GPR143(display_short)|uniprotkb:OA1(gene name synonym)|uniprotkb:Ocular albinism type 1 protein(gene name synonym)	psi-mi:tyro_human(display_long)|uniprotkb:LB24-AB(gene name synonym)|uniprotkb:Monophenol monooxygenase(gene name synonym)|uniprotkb:SK29-AB(gene name synonym)|uniprotkb:Tumor rejection antigen AB(gene name synonym)|uniprotkb:TYR(gene name)|psi-mi:TYR(display_short)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	De et al. (2017)	pubmed:27720922|imex:IM-27642	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25398113|imex:IM-27642-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007186"(G protein-coupled receptor signaling pathway)|ensembl:ENSG00000101850(gene)|go:"GO:0007601"(visual perception)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|ensembl:ENST00000467482(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0032400"(melanosome localization)|go:"GO:0032402"(melanosome transport)|go:"GO:0032438"(melanosome organization)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0033162"(melanosome membrane)|go:"GO:0035240"(dopamine binding)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0005886"(plasma membrane)|go:"GO:0035643"(L-DOPA receptor activity)|go:"GO:0042470"(melanosome)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0050848"(regulation of calcium-mediated signaling)|go:"GO:0006726"(eye pigment biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0072544"(L-DOPA binding)|go:"GO:0072545"(tyrosine binding)|interpro:IPR001414(Ocular albinism protein, type 1)|reactome:R-HSA-375280|reactome:R-HSA-416476|refseq:NP_000264.2|dip:DIP-53284N	go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043473"(pigmentation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048538"(thymus development)|go:"GO:0051591"(response to cAMP)|interpro:IPR002227(Tyrosinase)|interpro:IPR008922(Di-copper centre-containing)|reactome:R-HSA-5662702|ensembl:ENSG00000077498(gene)|ensembl:ENST00000263321(transcript)|go:"GO:0004503"(tyrosinase activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005829"(cytosol)|go:"GO:0006583"(melanin biosynthetic process from tyrosine)|go:"GO:0006726"(eye pigment biosynthetic process)|go:"GO:0007601"(visual perception)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009411"(response to UV)|go:"GO:0009637"(response to blue light)|go:"GO:0016021"(integral component of membrane)|go:"GO:0033162"(melanosome membrane)|go:"GO:0033280"(response to vitamin D)|go:"GO:0042438"(melanin biosynthetic process)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|refseq:NP_000363.1	-	-	-	figure legend:4, 5, S5, S6, S7, S8|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2020/01/14	2020/01/15	rogid:5MujRgqKPE16sLr4bggbtISx2Io9606	rogid:uCwNyknCSUxNSdTD5/IR/+E2dro9606	rigid:6xTfqn5mJpahO+3+cF0Te9lTjT0	false	mutation with no effect:223-224,329-330|enhanced yellow fluorescent protein tag:c-c	cyan fluorescent protein tag:c-c	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)