#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q6CIU1	uniprotkb:Q6CPV9	intact:EBI-25398500|ensemblfungi:CAG98856	intact:EBI-25398516|ensemblfungi:CAG99117	psi-mi:q6ciu1_klula(display_long)|uniprotkb:KLLA0_F23980g(orf name)	psi-mi:q6cpv9_klula(display_long)|uniprotkb:KLLA0_E01827g(orf name)	psi-mi:"MI:0114"(x-ray crystallography)	Charenton et al. (2016)	imex:IM-27819|pubmed:27694841	taxid:284590(klula)|taxid:284590("Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)")	taxid:284590(klula)|taxid:284590("Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-25398498|wwpdb:5LOP|imex:IM-27819-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_456148.1|rcsb pdb:5LON|rcsb pdb:5LOP|rcsb pdb:6AM0|interpro:IPR007722(Dcp2, box A)|interpro:IPR036189|ensemblfungi:CAG98856(transcript)|ensemblfungi:KLLA0_F23980g(gene)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0030145"(manganese ion binding)|go:"GO:0050072"("m7G(5')pppN diphosphatase activity")|interpro:IPR015797(NUDIX)|interpro:IPR020084|interpro:IPR000086(NUDIX hydrolase, core)|interpro:IPR044099	go:"GO:0098745"(Dcp1-Dcp2 complex)|ensemblfungi:CAG99117(transcript)|ensemblfungi:KLLA0_E01827g(gene)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0098562"(cytoplasmic side of membrane)|refseq:XP_454030.1|rcsb pdb:5LON|rcsb pdb:5LOP|rcsb pdb:6AM0|interpro:IPR010334(Dcp1-like decapping)|interpro:IPR011993(Pleckstrin homology-type)	-	-	-	figure legend:Fig 1, Table 1, Supplementary Fig 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:284590(klula)|taxid:284590("Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)")	-	2020/01/15	2020/01/16	rogid:2XNx07hut2TWjN2lW24Q2i7itvE284590	rogid:7j9bQE9aOUgusdbhLgm9TZbrlOs284590	rigid:JUJOKhj+/dZvdksqOR/wBio3Rao	false	binding-associated region:1-275	-	1	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:Q6CIU1	uniprotkb:Q6CX48	intact:EBI-25398500|ensemblfungi:CAG98856	intact:EBI-25398533|ensemblfungi:CAH03079	psi-mi:q6ciu1_klula(display_long)|uniprotkb:KLLA0_F23980g(orf name)	psi-mi:q6cx48_klula(display_long)|uniprotkb:KLLA0_A11308g(orf name)	psi-mi:"MI:0114"(x-ray crystallography)	Charenton et al. (2016)	imex:IM-27819|pubmed:27694841	taxid:284590(klula)|taxid:284590("Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)")	taxid:284590(klula)|taxid:284590("Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-25398498|wwpdb:5LOP|imex:IM-27819-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_456148.1|rcsb pdb:5LON|rcsb pdb:5LOP|rcsb pdb:6AM0|interpro:IPR007722(Dcp2, box A)|interpro:IPR036189|ensemblfungi:CAG98856(transcript)|ensemblfungi:KLLA0_F23980g(gene)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0030145"(manganese ion binding)|go:"GO:0050072"("m7G(5')pppN diphosphatase activity")|interpro:IPR015797(NUDIX)|interpro:IPR020084|interpro:IPR000086(NUDIX hydrolase, core)|interpro:IPR044099	ensemblfungi:CAH03079(transcript)|ensemblfungi:KLLA0_A11308g(gene)|go:"GO:0000932"(P-body)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0031087"(deadenylation-independent decapping of nuclear-transcribed mRNA)|go:"GO:0033962"(P-body assembly)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|refseq:XP_451491.1|rcsb pdb:5LOP|rcsb pdb:6AM0|interpro:IPR025762|interpro:IPR019050|interpro:IPR004443(YjeF-related protein, N-terminal)|interpro:IPR036652	-	-	-	figure legend:Fig 1, Table 1, Supplementary Fig 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:284590(klula)|taxid:284590("Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)")	-	2020/01/15	2020/01/16	rogid:2XNx07hut2TWjN2lW24Q2i7itvE284590	rogid:f1KI1QRlr6GuemXApgK4l8PS2Wo284590	rigid:JUJOKhj+/dZvdksqOR/wBio3Rao	false	binding-associated region:1-275	binding-associated region:1-66	1	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:Q6CPV9	uniprotkb:Q6CIU1	intact:EBI-25398516|ensemblfungi:CAG99117	intact:EBI-25398500|ensemblfungi:CAG98856	psi-mi:q6cpv9_klula(display_long)|uniprotkb:KLLA0_E01827g(orf name)	psi-mi:q6ciu1_klula(display_long)|uniprotkb:KLLA0_F23980g(orf name)	psi-mi:"MI:0114"(x-ray crystallography)	Charenton et al. (2016)	imex:IM-27819|pubmed:27694841	taxid:284590(klula)|taxid:284590("Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)")	taxid:284590(klula)|taxid:284590("Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-25398558|wwpdb:5LON|imex:IM-27819-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0098745"(Dcp1-Dcp2 complex)|ensemblfungi:CAG99117(transcript)|ensemblfungi:KLLA0_E01827g(gene)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0098562"(cytoplasmic side of membrane)|refseq:XP_454030.1|rcsb pdb:5LON|rcsb pdb:5LOP|rcsb pdb:6AM0|interpro:IPR010334(Dcp1-like decapping)|interpro:IPR011993(Pleckstrin homology-type)	refseq:XP_456148.1|rcsb pdb:5LON|rcsb pdb:5LOP|rcsb pdb:6AM0|interpro:IPR007722(Dcp2, box A)|interpro:IPR036189|ensemblfungi:CAG98856(transcript)|ensemblfungi:KLLA0_F23980g(gene)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0030145"(manganese ion binding)|go:"GO:0050072"("m7G(5')pppN diphosphatase activity")|interpro:IPR015797(NUDIX)|interpro:IPR020084|interpro:IPR000086(NUDIX hydrolase, core)|interpro:IPR044099	-	-	-	figure legend:Fig 1, Table 1, Supplementary Fig 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:284590(klula)|taxid:284590("Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)")	-	2020/01/15	2020/01/16	rogid:7j9bQE9aOUgusdbhLgm9TZbrlOs284590	rogid:2XNx07hut2TWjN2lW24Q2i7itvE284590	rigid:lHuFWfnuCjsfPKDhDguPLRVcqMI	false	-	binding-associated region:1-275	1	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:Q6CIU1	uniprotkb:Q6CX48	intact:EBI-25398500|ensemblfungi:CAG98856	intact:EBI-25398533|ensemblfungi:CAH03079	psi-mi:q6ciu1_klula(display_long)|uniprotkb:KLLA0_F23980g(orf name)	psi-mi:q6cx48_klula(display_long)|uniprotkb:KLLA0_A11308g(orf name)	psi-mi:"MI:0096"(pull down)	Charenton et al. (2016)	imex:IM-27819|pubmed:27694841	taxid:284590(klula)|taxid:284590("Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)")	taxid:284590(klula)|taxid:284590("Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-25398581|imex:IM-27819-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_456148.1|rcsb pdb:5LON|rcsb pdb:5LOP|rcsb pdb:6AM0|interpro:IPR007722(Dcp2, box A)|interpro:IPR036189|ensemblfungi:CAG98856(transcript)|ensemblfungi:KLLA0_F23980g(gene)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0030145"(manganese ion binding)|go:"GO:0050072"("m7G(5')pppN diphosphatase activity")|interpro:IPR015797(NUDIX)|interpro:IPR020084|interpro:IPR000086(NUDIX hydrolase, core)|interpro:IPR044099	ensemblfungi:CAH03079(transcript)|ensemblfungi:KLLA0_A11308g(gene)|go:"GO:0000932"(P-body)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0031087"(deadenylation-independent decapping of nuclear-transcribed mRNA)|go:"GO:0033962"(P-body assembly)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|refseq:XP_451491.1|rcsb pdb:5LOP|rcsb pdb:6AM0|interpro:IPR025762|interpro:IPR019050|interpro:IPR004443(YjeF-related protein, N-terminal)|interpro:IPR036652	-	-	-	figure legend:Supplementary Fig 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/01/15	2020/03/18	rogid:2XNx07hut2TWjN2lW24Q2i7itvE284590	rogid:f1KI1QRlr6GuemXApgK4l8PS2Wo284590	rigid:JUJOKhj+/dZvdksqOR/wBio3Rao	false	his tag:?-?|sufficient binding region:1-271	binding-associated region:1-66	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)|psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)|psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6CIU1	uniprotkb:Q6CPV9	intact:EBI-25398500|ensemblfungi:CAG98856	intact:EBI-25398516|ensemblfungi:CAG99117	psi-mi:q6ciu1_klula(display_long)|uniprotkb:KLLA0_F23980g(orf name)	psi-mi:q6cpv9_klula(display_long)|uniprotkb:KLLA0_E01827g(orf name)	psi-mi:"MI:0096"(pull down)	Charenton et al. (2016)	imex:IM-27819|pubmed:27694841	taxid:284590(klula)|taxid:284590("Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)")	taxid:284590(klula)|taxid:284590("Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-25398581|imex:IM-27819-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_456148.1|rcsb pdb:5LON|rcsb pdb:5LOP|rcsb pdb:6AM0|interpro:IPR007722(Dcp2, box A)|interpro:IPR036189|ensemblfungi:CAG98856(transcript)|ensemblfungi:KLLA0_F23980g(gene)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0030145"(manganese ion binding)|go:"GO:0050072"("m7G(5')pppN diphosphatase activity")|interpro:IPR015797(NUDIX)|interpro:IPR020084|interpro:IPR000086(NUDIX hydrolase, core)|interpro:IPR044099	go:"GO:0098745"(Dcp1-Dcp2 complex)|ensemblfungi:CAG99117(transcript)|ensemblfungi:KLLA0_E01827g(gene)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0098562"(cytoplasmic side of membrane)|refseq:XP_454030.1|rcsb pdb:5LON|rcsb pdb:5LOP|rcsb pdb:6AM0|interpro:IPR010334(Dcp1-like decapping)|interpro:IPR011993(Pleckstrin homology-type)	-	-	-	figure legend:Supplementary Fig 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/01/15	2020/03/18	rogid:2XNx07hut2TWjN2lW24Q2i7itvE284590	rogid:7j9bQE9aOUgusdbhLgm9TZbrlOs284590	rigid:JUJOKhj+/dZvdksqOR/wBio3Rao	false	his tag:?-?|sufficient binding region:1-271	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)|psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)|psi-mi:"MI:0396"(predetermined participant)