#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P17676	ensembl:ENSG00000136244	intact:EBI-969696|intact:EBI-28973829|ensembl:ENSP00000305422|uniprotkb:Q96IH2|uniprotkb:Q9H4Z5|uniprotkb:A8K671	intact:EBI-11316349	psi-mi:cebpb_human(display_long)|uniprotkb:CEBPB(gene name)|psi-mi:CEBPB(display_short)|uniprotkb:TCF5(gene name synonym)|uniprotkb:PP9092(orf name)|uniprotkb:Liver activator protein(gene name synonym)|uniprotkb:Nuclear factor NF-IL6(gene name synonym)|uniprotkb:Transcription factor 5(gene name synonym)|uniprotkb:Liver-enriched inhibitory protein(gene name synonym)	uniprotkb:IL6(gene name)|psi-mi:IL6(display_short)|uniprotkb:IFNB2(gene name synonym)|ensembl:il6_human_gene(shortlabel)|psi-mi:ENSG00000136244(display_long)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Péant et al. (2017)	pubmed:27577074|imex:IM-28321	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25824166|imex:IM-28321-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0250"(gene)	refseq:NP_001272807.1|refseq:NP_001272808.1|ensembl:ENSG00000172216(gene)|ensembl:ENST00000303004(transcript)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002432"(granuloma formation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006953"(acute-phase response)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007613"(memory)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019900"(kinase binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035711"(T-helper 1 cell activation)|go:"GO:0036488"(CHOP-C/EBP complex)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070169"(positive regulation of biomineral tissue development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072574"(hepatocyte proliferation)|go:"GO:0097421"(liver regeneration)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901329"(regulation of odontoblast differentiation)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000120"(positive regulation of sodium-dependent phosphate transport)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:2001198"(regulation of dendritic cell differentiation)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR016468(CCAAT/enhancer-binding)|mint:P17676|rcsb pdb:1GTW|rcsb pdb:1GU4|rcsb pdb:1GU5|rcsb pdb:1H88|rcsb pdb:1H89|rcsb pdb:1H8A|rcsb pdb:1HJB|rcsb pdb:1IO4|rcsb pdb:2E42|rcsb pdb:2E43|rcsb pdb:6MG1|rcsb pdb:6MG2|rcsb pdb:6MG3|reactome:R-HSA-2559582|reactome:R-HSA-380994|reactome:R-HSA-381340|reactome:R-HSA-8853884|reactome:R-HSA-9616222|reactome:R-HSA-9633012|reactome:R-HSA-9648895|ensembl:ENSP00000305422|refseq:NP_005185.2|dip:DIP-35345N	refseq:NP_000591.1|refseq:XP_011513692.1	-	-	-	figure legend:4F|agonist:"doxycycline (CHEBI:50845 )"|comment:Dox-induced IKKe showed an increase of IL-6 endogenous promoter region occupancy by C/EBP-beta in 22Rv1-6TR-pTrexIKKe cells compared to the controls.|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-22rv1)|taxid:9606(Homo sapiens)	-	2020/09/07	2020/09/07	rogid:RZKdnZRt48VZoER/NDVHSDFzqEA9606	-	-	false	flag tag:c-c	sufficient binding region:?-?	-	-	psi-mi:"MI:1195"(quantitative pcr)	psi-mi:"MI:1195"(quantitative pcr)
uniprotkb:P17676	uniprotkb:Q14164	intact:EBI-969696|intact:EBI-28973829|ensembl:ENSP00000305422|uniprotkb:Q96IH2|uniprotkb:Q9H4Z5|uniprotkb:A8K671	intact:EBI-307369|uniprotkb:Q3KR43|uniprotkb:Q5JTS6|uniprotkb:D3DT78|ensembl:ENSP00000464030|uniprotkb:Q3B754	psi-mi:cebpb_human(display_long)|uniprotkb:CEBPB(gene name)|psi-mi:CEBPB(display_short)|uniprotkb:TCF5(gene name synonym)|uniprotkb:PP9092(orf name)|uniprotkb:Liver activator protein(gene name synonym)|uniprotkb:Nuclear factor NF-IL6(gene name synonym)|uniprotkb:Transcription factor 5(gene name synonym)|uniprotkb:Liver-enriched inhibitory protein(gene name synonym)	psi-mi:ikke_human(display_long)|uniprotkb:IKBKE(gene name)|psi-mi:IKBKE(display_short)|uniprotkb:IKKE(gene name synonym)|uniprotkb:IKKI(gene name synonym)|uniprotkb:KIAA0151(gene name synonym)|uniprotkb:Inducible I kappa-B kinase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Péant et al. (2017)	pubmed:27577074|imex:IM-28321	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25824192|imex:IM-28321-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001272807.1|refseq:NP_001272808.1|ensembl:ENSG00000172216(gene)|ensembl:ENST00000303004(transcript)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002432"(granuloma formation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006953"(acute-phase response)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007613"(memory)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019900"(kinase binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035711"(T-helper 1 cell activation)|go:"GO:0036488"(CHOP-C/EBP complex)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070169"(positive regulation of biomineral tissue development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072574"(hepatocyte proliferation)|go:"GO:0097421"(liver regeneration)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901329"(regulation of odontoblast differentiation)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000120"(positive regulation of sodium-dependent phosphate transport)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:2001198"(regulation of dendritic cell differentiation)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR016468(CCAAT/enhancer-binding)|mint:P17676|rcsb pdb:1GTW|rcsb pdb:1GU4|rcsb pdb:1GU5|rcsb pdb:1H88|rcsb pdb:1H89|rcsb pdb:1H8A|rcsb pdb:1HJB|rcsb pdb:1IO4|rcsb pdb:2E42|rcsb pdb:2E43|rcsb pdb:6MG1|rcsb pdb:6MG2|rcsb pdb:6MG3|reactome:R-HSA-2559582|reactome:R-HSA-380994|reactome:R-HSA-381340|reactome:R-HSA-8853884|reactome:R-HSA-9616222|reactome:R-HSA-9633012|reactome:R-HSA-9648895|ensembl:ENSP00000305422|refseq:NP_005185.2|dip:DIP-35345N	refseq:NP_001180250.1|refseq:NP_001180251.1|refseq:NP_054721.1|ensembl:ENSG00000263528(gene)|ensembl:ENST00000581977(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004704"(NF-kappaB-inducing kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0008384"(IkappaB kinase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010467"(gene expression)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034340"(response to type I interferon)|go:"GO:0035456"(response to interferon-beta)|go:"GO:0036435"(K48-linked polyubiquitin modification-dependent protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:0098586"(cellular response to virus)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR041087|interpro:IPR041309|mint:Q14164|reactome:R-HSA-4755510|reactome:R-HSA-9013973|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-936440|reactome:R-HSA-936964|refseq:XP_005273413.1|dip:DIP-27530N	-	-	-	figure legend:5A|agonist:"doxycycline (CHEBI:50845 )"|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-22rv1)|taxid:9606(Homo sapiens)	-	2020/09/07	2020/09/07	rogid:RZKdnZRt48VZoER/NDVHSDFzqEA9606	rogid:Ml1E20UjGfHuuL3MqOLVBbv8ZmU9606	rigid:rHnhJAMiNNxTzd0Qhemhqfj3+xU	false	flag tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)