#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P04114	uniprotkb:P55157	intact:EBI-3926040|uniprotkb:Q9UMN0|uniprotkb:P78479|uniprotkb:P78480|uniprotkb:Q7Z600|uniprotkb:Q13786|uniprotkb:O00502|uniprotkb:P78481|uniprotkb:Q4ZG63|uniprotkb:Q13779|uniprotkb:Q13788|uniprotkb:Q13785|uniprotkb:Q13787|uniprotkb:Q53QC8|ensembl:ENSP00000233242	intact:EBI-11614052|uniprotkb:A8K428|uniprotkb:Q08AM4|uniprotkb:Q6P5T3|ensembl:ENSP00000265517|ensembl:ENSP00000400821	psi-mi:apob_human(display_long)|uniprotkb:APOB(gene name)|psi-mi:APOB(display_short)	psi-mi:mtp_human(display_long)|uniprotkb:MTTP(gene name)|psi-mi:MTTP(display_short)|uniprotkb:MTP(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Walsh et al. (2016)	pubmed:27487388|imex:IM-27794	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25470986|imex:IM-27794-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000375.2|ensembl:ENSG00000084674(gene)|ensembl:ENST00000233242(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006642"(triglyceride mobilization)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007399"(nervous system development)|go:"GO:0008201"(heparin binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009566"(fertilization)|go:"GO:0009615"(response to virus)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010008"(endosome membrane)|go:"GO:0010269"(response to selenium ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0010886"(positive regulation of cholesterol storage)|go:"GO:0019433"(triglyceride catabolic process)|go:"GO:0030301"(cholesterol transport)|go:"GO:0030317"(flagellated sperm motility)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031904"(endosome lumen)|go:"GO:0031983"(vesicle lumen)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0034359"(mature chylomicron)|go:"GO:0034360"(chylomicron remnant)|go:"GO:0034361"(very-low-density lipoprotein particle)|go:"GO:0034362"(low-density lipoprotein particle)|go:"GO:0034363"(intermediate-density lipoprotein particle)|go:"GO:0034364"(high-density lipoprotein particle)|go:"GO:0034374"(low-density lipoprotein particle remodeling)|go:"GO:0034379"(very-low-density lipoprotein particle assembly)|go:"GO:0034383"(low-density lipoprotein particle clearance)|go:"GO:0035473"(lipase binding)|go:"GO:0042158"(lipoprotein biosynthetic process)|go:"GO:0042159"(lipoprotein catabolic process)|go:"GO:0042627"(chylomicron)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042953"(lipoprotein transport)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045540"(regulation of cholesterol biosynthetic process)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071379"(cellular response to prostaglandin stimulus)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0120020"(cholesterol transfer activity)|interpro:IPR001747(Lipid transport protein, N-terminal)|interpro:IPR009454(Lipid transport, open beta-sheet)|interpro:IPR011030(Vitellinogen, superhelical)|interpro:IPR015255(Vitellinogen, open beta-sheet)|interpro:IPR015816(Vitellinogen, beta-sheet N-terminal)|interpro:IPR015819(Lipid transport protein, beta-sheet shell)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR022176|mint:P04114|reactome:R-HSA-202733|reactome:R-HSA-3000471|reactome:R-HSA-3000480|reactome:R-HSA-3000484|reactome:R-HSA-3000497|reactome:R-HSA-381426|reactome:R-HSA-432142|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866423|reactome:R-HSA-8957275|reactome:R-HSA-8963888|reactome:R-HSA-8963901|reactome:R-HSA-8964026|reactome:R-HSA-8964038|reactome:R-HSA-8964041|reactome:R-HSA-5686938|reactome:R-HSA-8964046|reactome:R-HSA-9707616|reactome:R-HSA-975634|dip:DIP-44767N	refseq:NP_000244.2|refseq:NP_001287714.1|ensembl:ENSG00000138823(gene)|ensembl:ENST00000265517(transcript)|ensembl:ENST00000457717(transcript)|go:"GO:0005319"(lipid transporter activity)|go:"GO:0005548"(phospholipid transporter activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006497"(protein lipidation)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008289"(lipid binding)|go:"GO:0009306"(protein secretion)|go:"GO:0015914"(phospholipid transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0031526"(brush border membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031982"(vesicle)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034197"(triglyceride transport)|go:"GO:0034374"(low-density lipoprotein particle remodeling)|go:"GO:0034377"(plasma lipoprotein particle assembly)|go:"GO:0034378"(chylomicron assembly)|go:"GO:0034379"(very-low-density lipoprotein particle assembly)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042953"(lipoprotein transport)|go:"GO:0043235"(receptor complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051592"(response to calcium ion)|go:"GO:0120014"(phospholipid transfer activity)|go:"GO:0120019"(phosphatidylcholine transfer activity)|go:"GO:0120020"(cholesterol transfer activity)|go:"GO:0140344"(triglyceride transfer activity)|go:"GO:1902388"(ceramide 1-phosphate transfer activity)|go:"GO:1904121"(phosphatidylethanolamine transfer activity)|interpro:IPR001747(Lipid transport protein, N-terminal)|interpro:IPR011030(Vitellinogen, superhelical)|interpro:IPR015816(Vitellinogen, beta-sheet N-terminal)|interpro:IPR015819(Lipid transport protein, beta-sheet shell)|interpro:IPR039988|reactome:R-HSA-8866423|reactome:R-HSA-8963888	-	-	-	figure legend:2e, 3b|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2020/03/16	2020/03/17	rogid:2A4FraaZg1hHoxDkvi6DsKpoCD49606	rogid:ZMnGnFUwQrq2OzWC/Cwkdy7Eb4s9606	rigid:oBIVqvyvBtZkFZ87wUeBJYfbEwQ	false	-	mutation with no effect:361-361|mutation with no effect:361-361|flag tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q4VIT4	uniprotkb:P55157	intact:EBI-22054129	intact:EBI-11614052|uniprotkb:A8K428|uniprotkb:Q08AM4|uniprotkb:Q6P5T3|ensembl:ENSP00000265517|ensembl:ENSP00000400821	psi-mi:pdia3_chlae(display_long)|uniprotkb:PDIA3(gene name)|psi-mi:PDIA3(display_short)|uniprotkb:ERP57(gene name synonym)|uniprotkb:Endoplasmic reticulum resident protein 57(gene name synonym)|uniprotkb:Endoplasmic reticulum resident protein 60(gene name synonym)	psi-mi:mtp_human(display_long)|uniprotkb:MTTP(gene name)|psi-mi:MTTP(display_short)|uniprotkb:MTP(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Walsh et al. (2016)	pubmed:27487388|imex:IM-27794	taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25471099|imex:IM-27794-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR005788(Disulphide isomerase)|interpro:IPR041868|interpro:IPR005792(Protein disulphide isomerase)|interpro:IPR036249|interpro:IPR017937|interpro:IPR013766(Thioredoxin domain)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0042470"(melanosome)	refseq:NP_000244.2|refseq:NP_001287714.1|ensembl:ENSG00000138823(gene)|ensembl:ENST00000265517(transcript)|ensembl:ENST00000457717(transcript)|go:"GO:0005319"(lipid transporter activity)|go:"GO:0005548"(phospholipid transporter activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006497"(protein lipidation)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008289"(lipid binding)|go:"GO:0009306"(protein secretion)|go:"GO:0015914"(phospholipid transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0031526"(brush border membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031982"(vesicle)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034197"(triglyceride transport)|go:"GO:0034374"(low-density lipoprotein particle remodeling)|go:"GO:0034377"(plasma lipoprotein particle assembly)|go:"GO:0034378"(chylomicron assembly)|go:"GO:0034379"(very-low-density lipoprotein particle assembly)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042953"(lipoprotein transport)|go:"GO:0043235"(receptor complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051592"(response to calcium ion)|go:"GO:0120014"(phospholipid transfer activity)|go:"GO:0120019"(phosphatidylcholine transfer activity)|go:"GO:0120020"(cholesterol transfer activity)|go:"GO:0140344"(triglyceride transfer activity)|go:"GO:1902388"(ceramide 1-phosphate transfer activity)|go:"GO:1904121"(phosphatidylethanolamine transfer activity)|interpro:IPR001747(Lipid transport protein, N-terminal)|interpro:IPR011030(Vitellinogen, superhelical)|interpro:IPR015816(Vitellinogen, beta-sheet N-terminal)|interpro:IPR015819(Lipid transport protein, beta-sheet shell)|interpro:IPR039988|reactome:R-HSA-8866423|reactome:R-HSA-8963888	-	-	-	figure legend:2k|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2020/03/16	2020/03/17	rogid:8apkt3KHKAv+ZOLbIR9pgauhf/Y9534	rogid:ZMnGnFUwQrq2OzWC/Cwkdy7Eb4s9606	rigid:1AgIzzsKdFZSlKRrj/Zt3D1nUKY	false	-	mutation with no effect:361-361|flag tag:c-c|mutation disrupting interaction strength:361-361	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P04114	uniprotkb:P55157	intact:EBI-3926040|uniprotkb:Q9UMN0|uniprotkb:P78479|uniprotkb:P78480|uniprotkb:Q7Z600|uniprotkb:Q13786|uniprotkb:O00502|uniprotkb:P78481|uniprotkb:Q4ZG63|uniprotkb:Q13779|uniprotkb:Q13788|uniprotkb:Q13785|uniprotkb:Q13787|uniprotkb:Q53QC8|ensembl:ENSP00000233242	intact:EBI-11614052|uniprotkb:A8K428|uniprotkb:Q08AM4|uniprotkb:Q6P5T3|ensembl:ENSP00000265517|ensembl:ENSP00000400821	psi-mi:apob_human(display_long)|uniprotkb:APOB(gene name)|psi-mi:APOB(display_short)	psi-mi:mtp_human(display_long)|uniprotkb:MTTP(gene name)|psi-mi:MTTP(display_short)|uniprotkb:MTP(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Walsh et al. (2016)	pubmed:27487388|imex:IM-27794	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25471081|imex:IM-27794-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000375.2|ensembl:ENSG00000084674(gene)|ensembl:ENST00000233242(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006642"(triglyceride mobilization)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007399"(nervous system development)|go:"GO:0008201"(heparin binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009566"(fertilization)|go:"GO:0009615"(response to virus)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010008"(endosome membrane)|go:"GO:0010269"(response to selenium ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0010886"(positive regulation of cholesterol storage)|go:"GO:0019433"(triglyceride catabolic process)|go:"GO:0030301"(cholesterol transport)|go:"GO:0030317"(flagellated sperm motility)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031904"(endosome lumen)|go:"GO:0031983"(vesicle lumen)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0034359"(mature chylomicron)|go:"GO:0034360"(chylomicron remnant)|go:"GO:0034361"(very-low-density lipoprotein particle)|go:"GO:0034362"(low-density lipoprotein particle)|go:"GO:0034363"(intermediate-density lipoprotein particle)|go:"GO:0034364"(high-density lipoprotein particle)|go:"GO:0034374"(low-density lipoprotein particle remodeling)|go:"GO:0034379"(very-low-density lipoprotein particle assembly)|go:"GO:0034383"(low-density lipoprotein particle clearance)|go:"GO:0035473"(lipase binding)|go:"GO:0042158"(lipoprotein biosynthetic process)|go:"GO:0042159"(lipoprotein catabolic process)|go:"GO:0042627"(chylomicron)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042953"(lipoprotein transport)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045540"(regulation of cholesterol biosynthetic process)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071379"(cellular response to prostaglandin stimulus)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0120020"(cholesterol transfer activity)|interpro:IPR001747(Lipid transport protein, N-terminal)|interpro:IPR009454(Lipid transport, open beta-sheet)|interpro:IPR011030(Vitellinogen, superhelical)|interpro:IPR015255(Vitellinogen, open beta-sheet)|interpro:IPR015816(Vitellinogen, beta-sheet N-terminal)|interpro:IPR015819(Lipid transport protein, beta-sheet shell)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR022176|mint:P04114|reactome:R-HSA-202733|reactome:R-HSA-3000471|reactome:R-HSA-3000480|reactome:R-HSA-3000484|reactome:R-HSA-3000497|reactome:R-HSA-381426|reactome:R-HSA-432142|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866423|reactome:R-HSA-8957275|reactome:R-HSA-8963888|reactome:R-HSA-8963901|reactome:R-HSA-8964026|reactome:R-HSA-8964038|reactome:R-HSA-8964041|reactome:R-HSA-5686938|reactome:R-HSA-8964046|reactome:R-HSA-9707616|reactome:R-HSA-975634|dip:DIP-44767N	refseq:NP_000244.2|refseq:NP_001287714.1|ensembl:ENSG00000138823(gene)|ensembl:ENST00000265517(transcript)|ensembl:ENST00000457717(transcript)|go:"GO:0005319"(lipid transporter activity)|go:"GO:0005548"(phospholipid transporter activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006497"(protein lipidation)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008289"(lipid binding)|go:"GO:0009306"(protein secretion)|go:"GO:0015914"(phospholipid transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0031526"(brush border membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031982"(vesicle)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034197"(triglyceride transport)|go:"GO:0034374"(low-density lipoprotein particle remodeling)|go:"GO:0034377"(plasma lipoprotein particle assembly)|go:"GO:0034378"(chylomicron assembly)|go:"GO:0034379"(very-low-density lipoprotein particle assembly)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042953"(lipoprotein transport)|go:"GO:0043235"(receptor complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051592"(response to calcium ion)|go:"GO:0120014"(phospholipid transfer activity)|go:"GO:0120019"(phosphatidylcholine transfer activity)|go:"GO:0120020"(cholesterol transfer activity)|go:"GO:0140344"(triglyceride transfer activity)|go:"GO:1902388"(ceramide 1-phosphate transfer activity)|go:"GO:1904121"(phosphatidylethanolamine transfer activity)|interpro:IPR001747(Lipid transport protein, N-terminal)|interpro:IPR011030(Vitellinogen, superhelical)|interpro:IPR015816(Vitellinogen, beta-sheet N-terminal)|interpro:IPR015819(Lipid transport protein, beta-sheet shell)|interpro:IPR039988|reactome:R-HSA-8866423|reactome:R-HSA-8963888	-	-	-	figure legend:2f, 3c|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2020/03/16	2020/03/17	rogid:2A4FraaZg1hHoxDkvi6DsKpoCD49606	rogid:ZMnGnFUwQrq2OzWC/Cwkdy7Eb4s9606	rigid:oBIVqvyvBtZkFZ87wUeBJYfbEwQ	false	sufficient binding region:1-781..781	mutation increasing interaction strength:361-361|mutation with no effect:361-361|flag tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q4VIT4	uniprotkb:P55157	intact:EBI-22054129	intact:EBI-11614052|uniprotkb:A8K428|uniprotkb:Q08AM4|uniprotkb:Q6P5T3|ensembl:ENSP00000265517|ensembl:ENSP00000400821	psi-mi:pdia3_chlae(display_long)|uniprotkb:PDIA3(gene name)|psi-mi:PDIA3(display_short)|uniprotkb:ERP57(gene name synonym)|uniprotkb:Endoplasmic reticulum resident protein 57(gene name synonym)|uniprotkb:Endoplasmic reticulum resident protein 60(gene name synonym)	psi-mi:mtp_human(display_long)|uniprotkb:MTTP(gene name)|psi-mi:MTTP(display_short)|uniprotkb:MTP(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Walsh et al. (2016)	pubmed:27487388|imex:IM-27794	taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25471197|imex:IM-27794-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR005788(Disulphide isomerase)|interpro:IPR041868|interpro:IPR005792(Protein disulphide isomerase)|interpro:IPR036249|interpro:IPR017937|interpro:IPR013766(Thioredoxin domain)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0042470"(melanosome)	refseq:NP_000244.2|refseq:NP_001287714.1|ensembl:ENSG00000138823(gene)|ensembl:ENST00000265517(transcript)|ensembl:ENST00000457717(transcript)|go:"GO:0005319"(lipid transporter activity)|go:"GO:0005548"(phospholipid transporter activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006497"(protein lipidation)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008289"(lipid binding)|go:"GO:0009306"(protein secretion)|go:"GO:0015914"(phospholipid transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0031526"(brush border membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031982"(vesicle)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034197"(triglyceride transport)|go:"GO:0034374"(low-density lipoprotein particle remodeling)|go:"GO:0034377"(plasma lipoprotein particle assembly)|go:"GO:0034378"(chylomicron assembly)|go:"GO:0034379"(very-low-density lipoprotein particle assembly)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042953"(lipoprotein transport)|go:"GO:0043235"(receptor complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051592"(response to calcium ion)|go:"GO:0120014"(phospholipid transfer activity)|go:"GO:0120019"(phosphatidylcholine transfer activity)|go:"GO:0120020"(cholesterol transfer activity)|go:"GO:0140344"(triglyceride transfer activity)|go:"GO:1902388"(ceramide 1-phosphate transfer activity)|go:"GO:1904121"(phosphatidylethanolamine transfer activity)|interpro:IPR001747(Lipid transport protein, N-terminal)|interpro:IPR011030(Vitellinogen, superhelical)|interpro:IPR015816(Vitellinogen, beta-sheet N-terminal)|interpro:IPR015819(Lipid transport protein, beta-sheet shell)|interpro:IPR039988|reactome:R-HSA-8866423|reactome:R-HSA-8963888	-	-	-	figure legend:2j, 3f|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2020/03/16	2020/03/17	rogid:8apkt3KHKAv+ZOLbIR9pgauhf/Y9534	rogid:ZMnGnFUwQrq2OzWC/Cwkdy7Eb4s9606	rigid:1AgIzzsKdFZSlKRrj/Zt3D1nUKY	false	-	mutation with no effect:361-361|flag tag:c-c|mutation decreasing interaction strength:361-361	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)