#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P32639	uniprotkb:P25337	intact:EBI-861|uniprotkb:D3DM80|ensemblfungi:YER172C	intact:EBI-547|ensemblfungi:YCR063W|uniprotkb:D6VR67	psi-mi:brr2_yeast(display_long)|uniprotkb:BRR2(gene name)|psi-mi:BRR2(display_short)|uniprotkb:RSS1(gene name synonym)|uniprotkb:SNU246(gene name synonym)|uniprotkb:YER172C(locus name)|uniprotkb:SYGP-ORF66(orf name)|uniprotkb:Protein Snu246(gene name synonym)	psi-mi:bud31_yeast(display_long)|uniprotkb:BUD31(gene name)|psi-mi:BUD31(display_short)|uniprotkb:Bud site selection protein 31(gene name synonym)|uniprotkb:CWC14(gene name synonym)|uniprotkb:Complexed with CEF1 protein 14(gene name synonym)|uniprotkb:YCR63W(orf name)|uniprotkb:YCR903(orf name)|uniprotkb:YCR063W(locus name)	psi-mi:"MI:0410"(3D electron microscopy)	Galej et al. (2016)	imex:IM-28615|pubmed:27459055	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26571711|wwpdb:5LJ5|emdb:EMD-4057|imex:IM-28615-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011099.1|sgd:S000000974|dip:DIP-850N|mint:P32639|ensemblfungi:YER172C(gene)|ensemblfungi:YER172C_mRNA(transcript)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|rcsb pdb:3HIB|rcsb pdb:3IM1|rcsb pdb:3IM2|rcsb pdb:3JCM|rcsb pdb:4BGD|rcsb pdb:5DCA|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GAP|rcsb pdb:5GM6|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5M52|rcsb pdb:5M5P|rcsb pdb:5NRL|rcsb pdb:5ZWM|rcsb pdb:5ZWO|rcsb pdb:7B9V	refseq:NP_009990.1|sgd:S000000659|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005686"(U2 snRNP)|interpro:IPR001748(G10 protein)|interpro:IPR018230|rcsb pdb:2MY1|ensemblfungi:YCR063W(gene)|ensemblfungi:YCR063W_mRNA(transcript)|go:"GO:0000282"(cellular bud site selection)|rcsb pdb:5GM6|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:5WSG|rcsb pdb:5Y88|rcsb pdb:5YLZ|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q|dip:DIP-1180N|mint:P25337	-	crc64:DFAF7E3B7168D944	crc64:70A8B15F8DA6F85D	figure legend:Fig 1, Extended Data Fig 2,3, Extended Data Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/12/25	2020/12/25	rogid:2bNoVkou3QatkNCtPIiSdvPdgEo559292	rogid:DImrf7jgUrSuQtfiOvBeJr5Cl/w559292	rigid:V4V9H2k5pPRmMkGb5ANtQTn8GUw	false	-	-	2	1	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P32639	uniprotkb:Q03654	intact:EBI-861|uniprotkb:D3DM80|ensemblfungi:YER172C	intact:EBI-476|uniprotkb:Q6B1D8|ensemblfungi:YMR213W|uniprotkb:D6W038	psi-mi:brr2_yeast(display_long)|uniprotkb:BRR2(gene name)|psi-mi:BRR2(display_short)|uniprotkb:RSS1(gene name synonym)|uniprotkb:SNU246(gene name synonym)|uniprotkb:YER172C(locus name)|uniprotkb:SYGP-ORF66(orf name)|uniprotkb:Protein Snu246(gene name synonym)	psi-mi:cef1_yeast(display_long)|uniprotkb:CEF1(gene name)|psi-mi:CEF1(display_short)|uniprotkb:YMR213W(locus name)|uniprotkb:YM8261.07(orf name)|uniprotkb:NTC85(gene name synonym)|uniprotkb:PRP nineteen-associated complex protein 85(gene name synonym)|uniprotkb:PRP19-associated complex protein 85(gene name synonym)	psi-mi:"MI:0410"(3D electron microscopy)	Galej et al. (2016)	imex:IM-28615|pubmed:27459055	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26571711|wwpdb:5LJ5|emdb:EMD-4057|imex:IM-28615-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011099.1|sgd:S000000974|dip:DIP-850N|mint:P32639|ensemblfungi:YER172C(gene)|ensemblfungi:YER172C_mRNA(transcript)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|rcsb pdb:3HIB|rcsb pdb:3IM1|rcsb pdb:3IM2|rcsb pdb:3JCM|rcsb pdb:4BGD|rcsb pdb:5DCA|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GAP|rcsb pdb:5GM6|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5M52|rcsb pdb:5M5P|rcsb pdb:5NRL|rcsb pdb:5ZWM|rcsb pdb:5ZWO|rcsb pdb:7B9V	refseq:NP_013940.1|sgd:S000004826|ensemblfungi:YMR213W(gene)|ensemblfungi:YMR213W_mRNA(transcript)|go:"GO:0000350"(generation of catalytic spliceosome for second transesterification step)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000974"(Prp19 complex)|go:"GO:0003677"(DNA binding)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0071006"(U2-type catalytic step 1 spliceosome)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017930|interpro:IPR021786|rcsb pdb:5GM6|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:5WSG|rcsb pdb:5Y88|rcsb pdb:5YLZ|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q|rcsb pdb:7DCO|dip:DIP-1113N|mint:Q03654	-	crc64:DFAF7E3B7168D944	crc64:A4C417A8B330EA9C	figure legend:Fig 1, Extended Data Fig 2,3, Extended Data Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/12/25	2020/12/25	rogid:2bNoVkou3QatkNCtPIiSdvPdgEo559292	rogid:AsbV7RtNk+8mCzLk2wZYqbULOFg559292	rigid:V4V9H2k5pPRmMkGb5ANtQTn8GUw	false	-	-	2	1	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P32639	uniprotkb:Q12309	intact:EBI-861|uniprotkb:D3DM80|ensemblfungi:YER172C	intact:EBI-484|uniprotkb:D6VYB5|ensemblfungi:YLR117C	psi-mi:brr2_yeast(display_long)|uniprotkb:BRR2(gene name)|psi-mi:BRR2(display_short)|uniprotkb:RSS1(gene name synonym)|uniprotkb:SNU246(gene name synonym)|uniprotkb:YER172C(locus name)|uniprotkb:SYGP-ORF66(orf name)|uniprotkb:Protein Snu246(gene name synonym)	psi-mi:clf1_yeast(display_long)|uniprotkb:CLF1(gene name)|psi-mi:CLF1(display_short)|uniprotkb:NTC77(gene name synonym)|uniprotkb:YLR117C(locus name)|uniprotkb:SYF3(gene name synonym)|uniprotkb:L2952(orf name)|uniprotkb:Crooked neck-like factor 1(gene name synonym)|uniprotkb:PRP19-associated complex protein 77(gene name synonym)|uniprotkb:Synthetic lethal with CDC40 protein 3(gene name synonym)	psi-mi:"MI:0410"(3D electron microscopy)	Galej et al. (2016)	imex:IM-28615|pubmed:27459055	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26571711|wwpdb:5LJ5|emdb:EMD-4057|imex:IM-28615-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011099.1|sgd:S000000974|dip:DIP-850N|mint:P32639|ensemblfungi:YER172C(gene)|ensemblfungi:YER172C_mRNA(transcript)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|rcsb pdb:3HIB|rcsb pdb:3IM1|rcsb pdb:3IM2|rcsb pdb:3JCM|rcsb pdb:4BGD|rcsb pdb:5DCA|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GAP|rcsb pdb:5GM6|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5M52|rcsb pdb:5M5P|rcsb pdb:5NRL|rcsb pdb:5ZWM|rcsb pdb:5ZWO|rcsb pdb:7B9V	refseq:NP_013218.1|sgd:S000004107|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q|rcsb pdb:5GM6|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:5WSG|rcsb pdb:5Y88|rcsb pdb:5YLZ|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:6J6G|ensemblfungi:YLR117C(gene)|ensemblfungi:YLR117C_mRNA(transcript)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000354"(cis assembly of pre-catalytic spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000785"(chromatin)|go:"GO:0000974"(Prp19 complex)|go:"GO:0003682"(chromatin binding)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0071004"(U2-type prespliceosome)|go:"GO:0071006"(U2-type catalytic step 1 spliceosome)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071008"(U2-type post-mRNA release spliceosomal complex)|go:"GO:0071014"(post-mRNA release spliceosomal complex)|interpro:IPR003107(RNA-processing protein, HAT helix)|interpro:IPR011990(Tetratricopeptide-like helical)|dip:DIP-1685N|mint:Q12309	-	crc64:DFAF7E3B7168D944	crc64:AE7D5EC5B3979E00	figure legend:Fig 1, Extended Data Fig 2,3, Extended Data Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/12/25	2020/12/25	rogid:2bNoVkou3QatkNCtPIiSdvPdgEo559292	rogid:VbNHO9YGUushIXHTgscFu4xCzC4559292	rigid:V4V9H2k5pPRmMkGb5ANtQTn8GUw	false	-	-	2	1	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P32639	uniprotkb:Q03375	intact:EBI-861|uniprotkb:D3DM80|ensemblfungi:YER172C	intact:EBI-30409|uniprotkb:D6VTA5|ensemblfungi:YDR482C	psi-mi:brr2_yeast(display_long)|uniprotkb:BRR2(gene name)|psi-mi:BRR2(display_short)|uniprotkb:RSS1(gene name synonym)|uniprotkb:SNU246(gene name synonym)|uniprotkb:YER172C(locus name)|uniprotkb:SYGP-ORF66(orf name)|uniprotkb:Protein Snu246(gene name synonym)	psi-mi:cwc21_yeast(display_long)|uniprotkb:YDR482C(locus name)|uniprotkb:Complexed with CEF1 protein 21(gene name synonym)|uniprotkb:CWC21(gene name)|psi-mi:CWC21(display_short)	psi-mi:"MI:0410"(3D electron microscopy)	Galej et al. (2016)	imex:IM-28615|pubmed:27459055	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26571711|wwpdb:5LJ5|emdb:EMD-4057|imex:IM-28615-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011099.1|sgd:S000000974|dip:DIP-850N|mint:P32639|ensemblfungi:YER172C(gene)|ensemblfungi:YER172C_mRNA(transcript)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|rcsb pdb:3HIB|rcsb pdb:3IM1|rcsb pdb:3IM2|rcsb pdb:3JCM|rcsb pdb:4BGD|rcsb pdb:5DCA|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GAP|rcsb pdb:5GM6|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5M52|rcsb pdb:5M5P|rcsb pdb:5NRL|rcsb pdb:5ZWM|rcsb pdb:5ZWO|rcsb pdb:7B9V	sgd:S000002890|refseq:NP_010770.3|dip:DIP-1847N|mint:Q03375|ensemblfungi:YDR482C(gene)|ensemblfungi:YDR482C_mRNA(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005684"(U2-type spliceosomal complex)|go:"GO:0005737"(cytoplasm)|interpro:IPR013170(mRNA splicing factor, Cwf21)|rcsb pdb:5GM6|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:5WSG|rcsb pdb:5YLZ|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q	-	crc64:DFAF7E3B7168D944	crc64:9723E1C0A393508B	figure legend:Fig 1, Extended Data Fig 2,3, Extended Data Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/12/25	2020/12/25	rogid:2bNoVkou3QatkNCtPIiSdvPdgEo559292	rogid:dXmh6RsUTTtGZ8d1CnRgs1Ma+VI559292	rigid:V4V9H2k5pPRmMkGb5ANtQTn8GUw	false	-	-	2	1	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P32639	uniprotkb:P53854	intact:EBI-861|uniprotkb:D3DM80|ensemblfungi:YER172C	intact:EBI-29221|uniprotkb:D6W0U8|ensemblfungi:YNL245C	psi-mi:brr2_yeast(display_long)|uniprotkb:BRR2(gene name)|psi-mi:BRR2(display_short)|uniprotkb:RSS1(gene name synonym)|uniprotkb:SNU246(gene name synonym)|uniprotkb:YER172C(locus name)|uniprotkb:SYGP-ORF66(orf name)|uniprotkb:Protein Snu246(gene name synonym)	psi-mi:cwc25_yeast(display_long)|uniprotkb:Complexed with CEF1 protein 25(gene name synonym)|uniprotkb:YNL245C(locus name)|uniprotkb:N0901(orf name)|uniprotkb:CWC25(gene name)|psi-mi:CWC25(display_short)	psi-mi:"MI:0410"(3D electron microscopy)	Galej et al. (2016)	imex:IM-28615|pubmed:27459055	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26571711|wwpdb:5LJ5|emdb:EMD-4057|imex:IM-28615-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011099.1|sgd:S000000974|dip:DIP-850N|mint:P32639|ensemblfungi:YER172C(gene)|ensemblfungi:YER172C_mRNA(transcript)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|rcsb pdb:3HIB|rcsb pdb:3IM1|rcsb pdb:3IM2|rcsb pdb:3JCM|rcsb pdb:4BGD|rcsb pdb:5DCA|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GAP|rcsb pdb:5GM6|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5M52|rcsb pdb:5M5P|rcsb pdb:5NRL|rcsb pdb:5ZWM|rcsb pdb:5ZWO|rcsb pdb:7B9V	refseq:NP_014154.1|sgd:S000005189|dip:DIP-2781N|ensemblfungi:YNL245C(gene)|ensemblfungi:YNL245C_mRNA(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005684"(U2-type spliceosomal complex)|interpro:IPR019339|interpro:IPR022209|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5	-	crc64:DFAF7E3B7168D944	-	figure legend:Fig 1, Extended Data Fig 2,3, Extended Data Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/12/25	2020/12/25	rogid:2bNoVkou3QatkNCtPIiSdvPdgEo559292	rogid:6bRgoCHPWEJzKP26V+7zR6CtCMY559292	rigid:V4V9H2k5pPRmMkGb5ANtQTn8GUw	false	-	-	2	2	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P32639	uniprotkb:Q12046	intact:EBI-861|uniprotkb:D3DM80|ensemblfungi:YER172C	intact:EBI-553|ensemblfungi:YDL209C|uniprotkb:D6VRE5	psi-mi:brr2_yeast(display_long)|uniprotkb:BRR2(gene name)|psi-mi:BRR2(display_short)|uniprotkb:RSS1(gene name synonym)|uniprotkb:SNU246(gene name synonym)|uniprotkb:YER172C(locus name)|uniprotkb:SYGP-ORF66(orf name)|uniprotkb:Protein Snu246(gene name synonym)	psi-mi:cwc2_yeast(display_long)|uniprotkb:CWC2(gene name)|psi-mi:CWC2(display_short)|uniprotkb:YDL209C(locus name)|uniprotkb:D1041(orf name)|uniprotkb:NTC40(gene name synonym)|uniprotkb:SLC3(gene name synonym)|uniprotkb:Complexed with CEF1 protein 2(gene name synonym)|uniprotkb:PRP19-associated complex protein 40(gene name synonym)|uniprotkb:Synthetic lethal with CLF1 protein 3(gene name synonym)	psi-mi:"MI:0410"(3D electron microscopy)	Galej et al. (2016)	imex:IM-28615|pubmed:27459055	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26571711|wwpdb:5LJ5|emdb:EMD-4057|imex:IM-28615-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011099.1|sgd:S000000974|dip:DIP-850N|mint:P32639|ensemblfungi:YER172C(gene)|ensemblfungi:YER172C_mRNA(transcript)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|rcsb pdb:3HIB|rcsb pdb:3IM1|rcsb pdb:3IM2|rcsb pdb:3JCM|rcsb pdb:4BGD|rcsb pdb:5DCA|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GAP|rcsb pdb:5GM6|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5M52|rcsb pdb:5M5P|rcsb pdb:5NRL|rcsb pdb:5ZWM|rcsb pdb:5ZWO|rcsb pdb:7B9V	interpro:IPR000571(Zinc finger, CCCH-type)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR032297|interpro:IPR034181|interpro:IPR035979|interpro:IPR039171|interpro:IPR039173|rcsb pdb:3TP2|rcsb pdb:3U1L|rcsb pdb:3U1M|rcsb pdb:5GM6|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:5WSG|rcsb pdb:5Y88|rcsb pdb:5YLZ|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|refseq:NP_010072.1|sgd:S000002368|ensemblfungi:YDL209C(gene)|ensemblfungi:YDL209C_mRNA(transcript)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000974"(Prp19 complex)|go:"GO:0007049"(cell cycle)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0045292"(mRNA cis splicing, via spliceosome)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0046872"(metal ion binding)|go:"GO:0071006"(U2-type catalytic step 1 spliceosome)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|interpro:IPR000504(RNA recognition motif, RNP-1)|rcsb pdb:6J6Q|dip:DIP-5164N	-	crc64:DFAF7E3B7168D944	crc64:371734A11DFDB339	figure legend:Fig 1, Extended Data Fig 2,3, Extended Data Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/12/25	2020/12/25	rogid:2bNoVkou3QatkNCtPIiSdvPdgEo559292	rogid:bCvRFfQxZ4QaBZqqOyQP7ye/UeQ559292	rigid:V4V9H2k5pPRmMkGb5ANtQTn8GUw	false	-	-	2	1	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P32639	uniprotkb:P21374	intact:EBI-861|uniprotkb:D3DM80|ensemblfungi:YER172C	intact:EBI-9382|ensemblfungi:YJR050W|uniprotkb:D6VWM1	psi-mi:brr2_yeast(display_long)|uniprotkb:BRR2(gene name)|psi-mi:BRR2(display_short)|uniprotkb:RSS1(gene name synonym)|uniprotkb:SNU246(gene name synonym)|uniprotkb:YER172C(locus name)|uniprotkb:SYGP-ORF66(orf name)|uniprotkb:Protein Snu246(gene name synonym)	psi-mi:isy1_yeast(display_long)|uniprotkb:ISY1(gene name)|psi-mi:ISY1(display_short)|uniprotkb:UTR3(gene name synonym)|uniprotkb:YJR050W(locus name)|uniprotkb:J1657(orf name)|uniprotkb:NTC30(gene name synonym)|uniprotkb:Interactor of SYF1(gene name synonym)|uniprotkb:PRP19-associated complex protein 30(gene name synonym)	psi-mi:"MI:0410"(3D electron microscopy)	Galej et al. (2016)	imex:IM-28615|pubmed:27459055	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26571711|wwpdb:5LJ5|emdb:EMD-4057|imex:IM-28615-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011099.1|sgd:S000000974|dip:DIP-850N|mint:P32639|ensemblfungi:YER172C(gene)|ensemblfungi:YER172C_mRNA(transcript)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|rcsb pdb:3HIB|rcsb pdb:3IM1|rcsb pdb:3IM2|rcsb pdb:3JCM|rcsb pdb:4BGD|rcsb pdb:5DCA|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GAP|rcsb pdb:5GM6|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5M52|rcsb pdb:5M5P|rcsb pdb:5NRL|rcsb pdb:5ZWM|rcsb pdb:5ZWO|rcsb pdb:7B9V	ensemblfungi:YJR050W(gene)|ensemblfungi:YJR050W_mRNA(transcript)|go:"GO:0000350"(generation of catalytic spliceosome for second transesterification step)|go:"GO:0000389"(mRNA 3'-splice site recognition)|go:"GO:0000974"(Prp19 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0071006"(U2-type catalytic step 1 spliceosome)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0071014"(post-mRNA release spliceosomal complex)|go:"GO:0071020"(post-spliceosomal complex)|interpro:IPR009360(Isy1-like splicing)|interpro:IPR029012|interpro:IPR037200|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q|reactome:R-SCE-6781823|reactome:R-SCE-6782135|reactome:R-SCE-6782210|sgd:S000003811|refseq:NP_012584.3|mint:P21374|dip:DIP-1682N	-	crc64:DFAF7E3B7168D944	-	figure legend:Fig 1, Extended Data Fig 2,3, Extended Data Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/12/25	2020/12/25	rogid:2bNoVkou3QatkNCtPIiSdvPdgEo559292	rogid:NHLAtd+wLxwtWQD8PsyzyQsfJOg559292	rigid:V4V9H2k5pPRmMkGb5ANtQTn8GUw	false	-	-	2	2	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P32639	uniprotkb:P40567	intact:EBI-861|uniprotkb:D3DM80|ensemblfungi:YER172C	intact:EBI-789|uniprotkb:D6VVT9|ensemblfungi:YIR009W	psi-mi:brr2_yeast(display_long)|uniprotkb:BRR2(gene name)|psi-mi:BRR2(display_short)|uniprotkb:RSS1(gene name synonym)|uniprotkb:SNU246(gene name synonym)|uniprotkb:YER172C(locus name)|uniprotkb:SYGP-ORF66(orf name)|uniprotkb:Protein Snu246(gene name synonym)	psi-mi:msl1_yeast(display_long)|uniprotkb:YIB9W(orf name)|uniprotkb:YIR009W(locus name)|uniprotkb:MSL1(gene name)|psi-mi:MSL1(display_short)	psi-mi:"MI:0410"(3D electron microscopy)	Galej et al. (2016)	imex:IM-28615|pubmed:27459055	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26571711|wwpdb:5LJ5|emdb:EMD-4057|imex:IM-28615-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011099.1|sgd:S000000974|dip:DIP-850N|mint:P32639|ensemblfungi:YER172C(gene)|ensemblfungi:YER172C_mRNA(transcript)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|rcsb pdb:3HIB|rcsb pdb:3IM1|rcsb pdb:3IM2|rcsb pdb:3JCM|rcsb pdb:4BGD|rcsb pdb:5DCA|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GAP|rcsb pdb:5GM6|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5M52|rcsb pdb:5M5P|rcsb pdb:5NRL|rcsb pdb:5ZWM|rcsb pdb:5ZWO|rcsb pdb:7B9V	refseq:NP_012274.1|sgd:S000001448|rcsb pdb:6BK8|ensemblfungi:YIR009W(gene)|ensemblfungi:YIR009W_mRNA(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005685"(U1 snRNP)|go:"GO:0030619"(U1 snRNA binding)|go:"GO:0030620"(U2 snRNA binding)|go:"GO:0071004"(U2-type prespliceosome)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5MQ0|rcsb pdb:5NRL|rcsb pdb:5WSG|rcsb pdb:5Y88|rcsb pdb:5YLZ|rcsb pdb:5ZWM|rcsb pdb:5ZWO|dip:DIP-816N|mint:P40567|rcsb pdb:6EXN|rcsb pdb:6G90|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q	-	crc64:DFAF7E3B7168D944	-	figure legend:Fig 1, Extended Data Fig 2,3, Extended Data Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/12/25	2020/12/25	rogid:2bNoVkou3QatkNCtPIiSdvPdgEo559292	rogid:GAiHZKcbfNjbem3+i1cZXFm4NfE559292	rigid:V4V9H2k5pPRmMkGb5ANtQTn8GUw	false	-	-	2	1	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P32639	uniprotkb:P15938	intact:EBI-861|uniprotkb:D3DM80|ensemblfungi:YER172C	intact:EBI-13829|ensemblfungi:YKR086W|uniprotkb:D6VXE6	psi-mi:brr2_yeast(display_long)|uniprotkb:BRR2(gene name)|psi-mi:BRR2(display_short)|uniprotkb:RSS1(gene name synonym)|uniprotkb:SNU246(gene name synonym)|uniprotkb:YER172C(locus name)|uniprotkb:SYGP-ORF66(orf name)|uniprotkb:Protein Snu246(gene name synonym)	psi-mi:prp16_yeast(display_long)|uniprotkb:PRP16(gene name)|psi-mi:PRP16(display_short)|uniprotkb:YKR406(orf name)|uniprotkb:YKR086W(locus name)	psi-mi:"MI:0410"(3D electron microscopy)	Galej et al. (2016)	imex:IM-28615|pubmed:27459055	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26571711|wwpdb:5LJ5|emdb:EMD-4057|imex:IM-28615-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011099.1|sgd:S000000974|dip:DIP-850N|mint:P32639|ensemblfungi:YER172C(gene)|ensemblfungi:YER172C_mRNA(transcript)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|rcsb pdb:3HIB|rcsb pdb:3IM1|rcsb pdb:3IM2|rcsb pdb:3JCM|rcsb pdb:4BGD|rcsb pdb:5DCA|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GAP|rcsb pdb:5GM6|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5M52|rcsb pdb:5M5P|rcsb pdb:5NRL|rcsb pdb:5ZWM|rcsb pdb:5ZWO|rcsb pdb:7B9V	ensemblfungi:YKR086W(gene)|ensemblfungi:YKR086W_mRNA(transcript)|go:"GO:0000350"(generation of catalytic spliceosome for second transesterification step)|go:"GO:0000378"(RNA exon ligation)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0008186"(ATP-dependent activity, acting on RNA)|go:"GO:0016073"(snRNA metabolic process)|go:"GO:0040031"(snRNA modification)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|interpro:IPR007502(Helicase-associated region)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR011709(Region of unknown function DUF1605)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|rcsb pdb:5LJ5|rcsb pdb:5WSG|sgd:S000001794|refseq:NP_013012.3|mint:P15938|dip:DIP-2824N	-	crc64:DFAF7E3B7168D944	-	figure legend:Fig 1, Extended Data Fig 2,3, Extended Data Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/12/25	2020/12/25	rogid:2bNoVkou3QatkNCtPIiSdvPdgEo559292	rogid:VqNrP9XJw1F9tua3l1D9XHyPOBM559292	rigid:V4V9H2k5pPRmMkGb5ANtQTn8GUw	false	-	-	2	1	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P32639	uniprotkb:P33411	intact:EBI-861|uniprotkb:D3DM80|ensemblfungi:YER172C	intact:EBI-13844|uniprotkb:Q02459|uniprotkb:Q05724|ensemblfungi:YGR006W|uniprotkb:D6VUE3	psi-mi:brr2_yeast(display_long)|uniprotkb:BRR2(gene name)|psi-mi:BRR2(display_short)|uniprotkb:RSS1(gene name synonym)|uniprotkb:SNU246(gene name synonym)|uniprotkb:YER172C(locus name)|uniprotkb:SYGP-ORF66(orf name)|uniprotkb:Protein Snu246(gene name synonym)	psi-mi:prp18_yeast(display_long)|uniprotkb:PRP18(gene name)|psi-mi:PRP18(display_short)|uniprotkb:YGR006W(locus name)	psi-mi:"MI:0410"(3D electron microscopy)	Galej et al. (2016)	imex:IM-28615|pubmed:27459055	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26571711|wwpdb:5LJ5|emdb:EMD-4057|imex:IM-28615-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011099.1|sgd:S000000974|dip:DIP-850N|mint:P32639|ensemblfungi:YER172C(gene)|ensemblfungi:YER172C_mRNA(transcript)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|rcsb pdb:3HIB|rcsb pdb:3IM1|rcsb pdb:3IM2|rcsb pdb:3JCM|rcsb pdb:4BGD|rcsb pdb:5DCA|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GAP|rcsb pdb:5GM6|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5M52|rcsb pdb:5M5P|rcsb pdb:5NRL|rcsb pdb:5ZWM|rcsb pdb:5ZWO|rcsb pdb:7B9V	ensemblfungi:YGR006W(gene)|ensemblfungi:YGR006W_mRNA(transcript)|go:"GO:0000350"(generation of catalytic spliceosome for second transesterification step)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005682"(U5 snRNP)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071021"(U2-type post-spliceosomal complex)|go:"GO:0071048"|interpro:IPR004098(Prp18)|interpro:IPR039979|rcsb pdb:1DVK|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:5WSG|rcsb pdb:5YLZ|rcsb pdb:6BK8|rcsb pdb:6EXN|refseq:NP_011520.2|sgd:S000003238|mint:P33411|dip:DIP-1110N	-	crc64:DFAF7E3B7168D944	-	figure legend:Fig 1, Extended Data Fig 2,3, Extended Data Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/12/25	2020/12/25	rogid:2bNoVkou3QatkNCtPIiSdvPdgEo559292	rogid:3OaVOaHslViUjLZSTUDVIVMo4WY559292	rigid:V4V9H2k5pPRmMkGb5ANtQTn8GUw	false	-	ha tag:?-?	2	1	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P32639	uniprotkb:P32523	intact:EBI-861|uniprotkb:D3DM80|ensemblfungi:YER172C	intact:EBI-493|uniprotkb:Q07870|ensemblfungi:YLL036C|uniprotkb:D6VXW9	psi-mi:brr2_yeast(display_long)|uniprotkb:BRR2(gene name)|psi-mi:BRR2(display_short)|uniprotkb:RSS1(gene name synonym)|uniprotkb:SNU246(gene name synonym)|uniprotkb:YER172C(locus name)|uniprotkb:SYGP-ORF66(orf name)|uniprotkb:Protein Snu246(gene name synonym)	psi-mi:prp19_yeast(display_long)|uniprotkb:PRP19(gene name)|psi-mi:PRP19(display_short)|uniprotkb:PSO4(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase PRP19(gene name synonym)|uniprotkb:YLL036C(locus name)	psi-mi:"MI:0410"(3D electron microscopy)	Galej et al. (2016)	imex:IM-28615|pubmed:27459055	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26571711|wwpdb:5LJ5|emdb:EMD-4057|imex:IM-28615-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011099.1|sgd:S000000974|dip:DIP-850N|mint:P32639|ensemblfungi:YER172C(gene)|ensemblfungi:YER172C_mRNA(transcript)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|rcsb pdb:3HIB|rcsb pdb:3IM1|rcsb pdb:3IM2|rcsb pdb:3JCM|rcsb pdb:4BGD|rcsb pdb:5DCA|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GAP|rcsb pdb:5GM6|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5M52|rcsb pdb:5M5P|rcsb pdb:5NRL|rcsb pdb:5ZWM|rcsb pdb:5ZWO|rcsb pdb:7B9V	refseq:NP_013064.1|sgd:S000003959|rcsb pdb:6EXN|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q|reactome:R-SCE-6781823|reactome:R-SCE-6782135|reactome:R-SCE-6782210|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR038959|rcsb pdb:1N87|rcsb pdb:2BAY|rcsb pdb:3LRV|rcsb pdb:4ZB4|rcsb pdb:5GM6|rcsb pdb:5GMK|rcsb pdb:5LJ5|rcsb pdb:5M8C|rcsb pdb:5MQ0|ensemblfungi:YLL036C(gene)|ensemblfungi:YLL036C_mRNA(transcript)|go:"GO:0000349"(generation of catalytic spliceosome for first transesterification step)|go:"GO:0000974"(Prp19 complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0042802"(identical protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071006"(U2-type catalytic step 1 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|interpro:IPR003613(U box)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013915(Pre-mRNA-splicing factor 19)|rcsb pdb:5WSG|rcsb pdb:5Y88|rcsb pdb:5YLZ|rcsb pdb:6BK8|dip:DIP-1112N|mint:P32523	-	crc64:DFAF7E3B7168D944	crc64:A44D8C7DD6F64185	figure legend:Fig 1, Extended Data Fig 2,3, Extended Data Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/12/25	2020/12/25	rogid:2bNoVkou3QatkNCtPIiSdvPdgEo559292	rogid:/oQc2rJZ7WcCIx7cnqE6XSW/3Vk559292	rigid:V4V9H2k5pPRmMkGb5ANtQTn8GUw	false	-	-	2	1	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P32639	uniprotkb:P28004	intact:EBI-861|uniprotkb:D3DM80|ensemblfungi:YER172C	intact:EBI-20640|uniprotkb:D6VPI6|ensemblfungi:YAL032C	psi-mi:brr2_yeast(display_long)|uniprotkb:BRR2(gene name)|psi-mi:BRR2(display_short)|uniprotkb:RSS1(gene name synonym)|uniprotkb:SNU246(gene name synonym)|uniprotkb:YER172C(locus name)|uniprotkb:SYGP-ORF66(orf name)|uniprotkb:Protein Snu246(gene name synonym)	psi-mi:prp45_yeast(display_long)|uniprotkb:YAL032C(locus name)|uniprotkb:PRP45(gene name)|psi-mi:PRP45(display_short)|uniprotkb:FUN20(gene name synonym)	psi-mi:"MI:0410"(3D electron microscopy)	Galej et al. (2016)	imex:IM-28615|pubmed:27459055	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26571711|wwpdb:5LJ5|emdb:EMD-4057|imex:IM-28615-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011099.1|sgd:S000000974|dip:DIP-850N|mint:P32639|ensemblfungi:YER172C(gene)|ensemblfungi:YER172C_mRNA(transcript)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|rcsb pdb:3HIB|rcsb pdb:3IM1|rcsb pdb:3IM2|rcsb pdb:3JCM|rcsb pdb:4BGD|rcsb pdb:5DCA|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GAP|rcsb pdb:5GM6|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5M52|rcsb pdb:5M5P|rcsb pdb:5NRL|rcsb pdb:5ZWM|rcsb pdb:5ZWO|rcsb pdb:7B9V	refseq:NP_009370.1|sgd:S000000030|ensemblfungi:YAL032C(gene)|ensemblfungi:YAL032C_mRNA(transcript)|go:"GO:0000350"(generation of catalytic spliceosome for second transesterification step)|go:"GO:0005634"(nucleus)|go:"GO:0071006"(U2-type catalytic step 1 spliceosome)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071014"(post-mRNA release spliceosomal complex)|interpro:IPR004015(SKIP/SNW)|interpro:IPR017862|rcsb pdb:5GM6|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:5WSG|rcsb pdb:5Y88|rcsb pdb:5YLZ|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q|dip:DIP-2774N|mint:P28004	-	crc64:DFAF7E3B7168D944	crc64:FE5A724186D7FE84	figure legend:Fig 1, Extended Data Fig 2,3, Extended Data Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/12/25	2020/12/25	rogid:2bNoVkou3QatkNCtPIiSdvPdgEo559292	rogid:qoHF1UsO3k+JOTOfigSuy2P84/k559292	rigid:V4V9H2k5pPRmMkGb5ANtQTn8GUw	false	-	-	2	1	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P32639	uniprotkb:Q12417	intact:EBI-861|uniprotkb:D3DM80|ensemblfungi:YER172C	intact:EBI-710|uniprotkb:D6W3L8|ensemblfungi:YPL151C	psi-mi:brr2_yeast(display_long)|uniprotkb:BRR2(gene name)|psi-mi:BRR2(display_short)|uniprotkb:RSS1(gene name synonym)|uniprotkb:SNU246(gene name synonym)|uniprotkb:YER172C(locus name)|uniprotkb:SYGP-ORF66(orf name)|uniprotkb:Protein Snu246(gene name synonym)	psi-mi:prp46_yeast(display_long)|uniprotkb:CWC1(gene name synonym)|uniprotkb:PRP nineteen-associated complex protein 50(gene name synonym)|uniprotkb:PRP19-associated complex protein 50(gene name synonym)|uniprotkb:P2594(orf name)|uniprotkb:YPL151C(locus name)|uniprotkb:PRP46(gene name)|psi-mi:PRP46(display_short)|uniprotkb:NTC50(gene name synonym)|uniprotkb:Pre-mRNA-processing protein 46(gene name synonym)|uniprotkb:Complexed with CEF1 protein 1(gene name synonym)	psi-mi:"MI:0410"(3D electron microscopy)	Galej et al. (2016)	imex:IM-28615|pubmed:27459055	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26571711|wwpdb:5LJ5|emdb:EMD-4057|imex:IM-28615-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011099.1|sgd:S000000974|dip:DIP-850N|mint:P32639|ensemblfungi:YER172C(gene)|ensemblfungi:YER172C_mRNA(transcript)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|rcsb pdb:3HIB|rcsb pdb:3IM1|rcsb pdb:3IM2|rcsb pdb:3JCM|rcsb pdb:4BGD|rcsb pdb:5DCA|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GAP|rcsb pdb:5GM6|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5M52|rcsb pdb:5M5P|rcsb pdb:5NRL|rcsb pdb:5ZWM|rcsb pdb:5ZWO|rcsb pdb:7B9V	refseq:NP_015174.1|sgd:S000006072|ensemblfungi:YPL151C(gene)|ensemblfungi:YPL151C_mRNA(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000974"(Prp19 complex)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|dip:DIP-3994N|mint:Q12417|rcsb pdb:5GM6|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:5WSG|rcsb pdb:5Y88|rcsb pdb:5YLZ|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q	-	crc64:DFAF7E3B7168D944	crc64:0E888F566A5414BD	figure legend:Fig 1, Extended Data Fig 2,3, Extended Data Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/12/25	2020/12/25	rogid:2bNoVkou3QatkNCtPIiSdvPdgEo559292	rogid:016ynVER9V3d44NwkqRG7TIvf9w559292	rigid:V4V9H2k5pPRmMkGb5ANtQTn8GUw	false	-	-	2	1	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P32639	uniprotkb:P33334	intact:EBI-861|uniprotkb:D3DM80|ensemblfungi:YER172C	intact:EBI-465|uniprotkb:D3DLB4|ensemblfungi:YHR165C	psi-mi:brr2_yeast(display_long)|uniprotkb:BRR2(gene name)|psi-mi:BRR2(display_short)|uniprotkb:RSS1(gene name synonym)|uniprotkb:SNU246(gene name synonym)|uniprotkb:YER172C(locus name)|uniprotkb:SYGP-ORF66(orf name)|uniprotkb:Protein Snu246(gene name synonym)	psi-mi:prp8_yeast(display_long)|uniprotkb:PRP8(gene name)|psi-mi:PRP8(display_short)|uniprotkb:DBF3(gene name synonym)|uniprotkb:DNA39(gene name synonym)|uniprotkb:RNA8(gene name synonym)|uniprotkb:SLT21(gene name synonym)|uniprotkb:USA2(gene name synonym)|uniprotkb:YHR165C(locus name)	psi-mi:"MI:0410"(3D electron microscopy)	Galej et al. (2016)	imex:IM-28615|pubmed:27459055	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26571711|wwpdb:5LJ5|emdb:EMD-4057|imex:IM-28615-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011099.1|sgd:S000000974|dip:DIP-850N|mint:P32639|ensemblfungi:YER172C(gene)|ensemblfungi:YER172C_mRNA(transcript)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|rcsb pdb:3HIB|rcsb pdb:3IM1|rcsb pdb:3IM2|rcsb pdb:3JCM|rcsb pdb:4BGD|rcsb pdb:5DCA|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GAP|rcsb pdb:5GM6|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5M52|rcsb pdb:5M5P|rcsb pdb:5NRL|rcsb pdb:5ZWM|rcsb pdb:5ZWO|rcsb pdb:7B9V	refseq:NP_012035.1|sgd:S000001208|rcsb pdb:4ILJ|rcsb pdb:5DCA|rcsb pdb:5GAM|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GAP|rcsb pdb:5GM6|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5M52|rcsb pdb:5M5P|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:5NRL|rcsb pdb:5QY1|rcsb pdb:5QY2|rcsb pdb:5QY3|rcsb pdb:5QY4|rcsb pdb:5QY5|rcsb pdb:5QY6|rcsb pdb:5QY7|rcsb pdb:5QY8|rcsb pdb:5QY9|rcsb pdb:5QYA|rcsb pdb:5QYB|rcsb pdb:5QYC|rcsb pdb:5QYD|rcsb pdb:5QYE|rcsb pdb:5QYF|rcsb pdb:5QYG|rcsb pdb:5QYH|rcsb pdb:5QYI|rcsb pdb:5QYJ|rcsb pdb:5QYK|rcsb pdb:5QYL|rcsb pdb:5QYM|rcsb pdb:5QYN|rcsb pdb:5QYO|rcsb pdb:5QYP|rcsb pdb:5QYQ|rcsb pdb:5QYR|rcsb pdb:5QYS|rcsb pdb:5QYT|rcsb pdb:5QYU|rcsb pdb:5QYV|rcsb pdb:5QYW|rcsb pdb:5QYX|rcsb pdb:5QYY|rcsb pdb:5QYZ|rcsb pdb:5QZ0|rcsb pdb:5QZ1|rcsb pdb:5QZ2|rcsb pdb:5QZ3|rcsb pdb:5QZ4|rcsb pdb:5QZ5|rcsb pdb:5QZ6|rcsb pdb:5QZ7|rcsb pdb:5QZ8|rcsb pdb:5QZ9|rcsb pdb:5QZA|rcsb pdb:5QZB|rcsb pdb:5QZC|rcsb pdb:5QZD|rcsb pdb:5QZE|rcsb pdb:5QZF|rcsb pdb:5QZG|rcsb pdb:5QZH|rcsb pdb:5QZI|rcsb pdb:5QZJ|rcsb pdb:5QZK|rcsb pdb:5QZL|rcsb pdb:5QZM|rcsb pdb:5QZN|rcsb pdb:5QZO|rcsb pdb:5QZP|rcsb pdb:5R14|rcsb pdb:5R15|rcsb pdb:5R16|rcsb pdb:5R17|rcsb pdb:5R18|rcsb pdb:5R19|rcsb pdb:5R1A|rcsb pdb:5R1B|rcsb pdb:5R1C|rcsb pdb:5R1D|rcsb pdb:5R1E|rcsb pdb:5R1F|rcsb pdb:5R1G|rcsb pdb:5R1H|rcsb pdb:5R1I|rcsb pdb:5R1J|rcsb pdb:5R1K|rcsb pdb:5R1L|rcsb pdb:5R1M|rcsb pdb:5R1N|rcsb pdb:5R1O|rcsb pdb:5R1P|rcsb pdb:5R1Q|rcsb pdb:5R1S|rcsb pdb:5WSG|rcsb pdb:5Y88|rcsb pdb:5YLZ|rcsb pdb:5ZWM|rcsb pdb:5ZWO|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q|rcsb pdb:6TEO|rcsb pdb:7B9V|rcsb pdb:5QZQ|rcsb pdb:5QZR|rcsb pdb:5QZS|rcsb pdb:5QZT|rcsb pdb:5QZU|rcsb pdb:5QZV|rcsb pdb:5QZW|rcsb pdb:5QZX|rcsb pdb:5QZY|rcsb pdb:5QZZ|rcsb pdb:5R00|rcsb pdb:5R01|rcsb pdb:5R02|rcsb pdb:5R03|rcsb pdb:5R04|rcsb pdb:5R05|rcsb pdb:5R06|rcsb pdb:5R07|rcsb pdb:5R08|rcsb pdb:5R09|rcsb pdb:5R0A|rcsb pdb:5R0B|rcsb pdb:5R0C|rcsb pdb:5R0D|rcsb pdb:5R0E|rcsb pdb:5R0F|rcsb pdb:5R0G|rcsb pdb:5R0H|rcsb pdb:5R0I|rcsb pdb:5R0J|rcsb pdb:5R0K|rcsb pdb:5R0L|rcsb pdb:5R0M|rcsb pdb:5R0N|rcsb pdb:5R0O|rcsb pdb:5R0P|rcsb pdb:5R0Q|rcsb pdb:5R0R|rcsb pdb:5R0S|rcsb pdb:5R0T|rcsb pdb:5R0U|rcsb pdb:5R0V|rcsb pdb:5R0W|rcsb pdb:5R0X|rcsb pdb:5R0Y|rcsb pdb:5R0Z|rcsb pdb:5R10|rcsb pdb:5R11|rcsb pdb:5R12|rcsb pdb:5R13|ensemblfungi:YHR165C(gene)|ensemblfungi:YHR165C_mRNA(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000350"(generation of catalytic spliceosome for second transesterification step)|go:"GO:0000389"(mRNA 3'-splice site recognition)|go:"GO:0000395"(mRNA 5'-splice site recognition)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005682"(U5 snRNP)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0030619"(U1 snRNA binding)|go:"GO:0030620"(U2 snRNA binding)|go:"GO:0030623"(U5 snRNA binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0071013"(catalytic step 2 spliceosome)|rcsb pdb:3SBT|rcsb pdb:3ZEF|rcsb pdb:4BGD|rcsb pdb:4I43|go:"GO:0097157"(pre-mRNA intronic binding)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR012591(PRO8NT)|interpro:IPR012592(PROCN)|interpro:IPR012984(PRO, C-terminal)|interpro:IPR019580|interpro:IPR019581|interpro:IPR019582|interpro:IPR021983|interpro:IPR027652|interpro:IPR037518|interpro:IPR042516|interpro:IPR043172|interpro:IPR043173|rcsb pdb:2OG4|rcsb pdb:3E66|rcsb pdb:3E9O|rcsb pdb:3E9P|rcsb pdb:3JCM|rcsb pdb:3SBG|rcsb pdb:4ILG|rcsb pdb:4ILH|dip:DIP-2427N|mint:P33334	-	crc64:DFAF7E3B7168D944	crc64:8F4F6F89D34D3508	figure legend:Fig 1, Extended Data Fig 2,3, Extended Data Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/12/25	2020/12/25	rogid:2bNoVkou3QatkNCtPIiSdvPdgEo559292	rogid:0JoVp7ULlbib7N5+GOPksHStSmY559292	rigid:V4V9H2k5pPRmMkGb5ANtQTn8GUw	false	-	-	2	4	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P32639	uniprotkb:P40018	intact:EBI-861|uniprotkb:D3DM80|ensemblfungi:YER172C	intact:EBI-432|uniprotkb:D3DLS8|ensemblfungi:YER029C	psi-mi:brr2_yeast(display_long)|uniprotkb:BRR2(gene name)|psi-mi:BRR2(display_short)|uniprotkb:RSS1(gene name synonym)|uniprotkb:SNU246(gene name synonym)|uniprotkb:YER172C(locus name)|uniprotkb:SYGP-ORF66(orf name)|uniprotkb:Protein Snu246(gene name synonym)	psi-mi:rsmb_yeast(display_long)|uniprotkb:SMB1(gene name)|psi-mi:SMB1(display_short)|uniprotkb:Sm protein B(gene name synonym)|uniprotkb:YER029C(locus name)	psi-mi:"MI:0410"(3D electron microscopy)	Galej et al. (2016)	imex:IM-28615|pubmed:27459055	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26571711|wwpdb:5LJ5|emdb:EMD-4057|imex:IM-28615-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011099.1|sgd:S000000974|dip:DIP-850N|mint:P32639|ensemblfungi:YER172C(gene)|ensemblfungi:YER172C_mRNA(transcript)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|rcsb pdb:3HIB|rcsb pdb:3IM1|rcsb pdb:3IM2|rcsb pdb:3JCM|rcsb pdb:4BGD|rcsb pdb:5DCA|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GAP|rcsb pdb:5GM6|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5M52|rcsb pdb:5M5P|rcsb pdb:5NRL|rcsb pdb:5ZWM|rcsb pdb:5ZWO|rcsb pdb:7B9V	sgd:S000000831|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:5NRL|rcsb pdb:5WSG|rcsb pdb:5Y88|rcsb pdb:5YLZ|rcsb pdb:5ZWM|rcsb pdb:5ZWN|rcsb pdb:5ZWO|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:6G90|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q|rcsb pdb:6N7P|rcsb pdb:6N7R|rcsb pdb:6N7X|rcsb pdb:7B9V|ensemblfungi:YER029C(gene)|ensemblfungi:YER029C_mRNA(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005682"(U5 snRNP)|go:"GO:0005685"(U1 snRNP)|go:"GO:0005686"(U2 snRNP)|go:"GO:0005687"(U4 snRNP)|go:"GO:0005737"(cytoplasm)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071004"(U2-type prespliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|rcsb pdb:3JCM|rcsb pdb:5GAM|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GM6|refseq:NP_010946.3|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5LQW|dip:DIP-843N|mint:P40018	-	crc64:DFAF7E3B7168D944	crc64:0A1078D5AA241430	figure legend:Fig 1, Extended Data Fig 2,3, Extended Data Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/12/25	2020/12/25	rogid:2bNoVkou3QatkNCtPIiSdvPdgEo559292	rogid:b62+dBOdvQgeE0oup4kbXbviS1U559292	rigid:V4V9H2k5pPRmMkGb5ANtQTn8GUw	false	-	-	2	1	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P32639	uniprotkb:Q08963	intact:EBI-861|uniprotkb:D3DM80|ensemblfungi:YER172C	intact:EBI-594|uniprotkb:D6W3F7|ensemblfungi:YPL213W	psi-mi:brr2_yeast(display_long)|uniprotkb:BRR2(gene name)|psi-mi:BRR2(display_short)|uniprotkb:RSS1(gene name synonym)|uniprotkb:SNU246(gene name synonym)|uniprotkb:YER172C(locus name)|uniprotkb:SYGP-ORF66(orf name)|uniprotkb:Protein Snu246(gene name synonym)	psi-mi:ru2a_yeast(display_long)|uniprotkb:YPL213W(locus name)|uniprotkb:LEA1(gene name)|psi-mi:LEA1(display_short)|uniprotkb:Looks exceptionally like U2A protein 1(gene name synonym)	psi-mi:"MI:0410"(3D electron microscopy)	Galej et al. (2016)	imex:IM-28615|pubmed:27459055	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26571711|wwpdb:5LJ5|emdb:EMD-4057|imex:IM-28615-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011099.1|sgd:S000000974|dip:DIP-850N|mint:P32639|ensemblfungi:YER172C(gene)|ensemblfungi:YER172C_mRNA(transcript)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|rcsb pdb:3HIB|rcsb pdb:3IM1|rcsb pdb:3IM2|rcsb pdb:3JCM|rcsb pdb:4BGD|rcsb pdb:5DCA|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GAP|rcsb pdb:5GM6|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5M52|rcsb pdb:5M5P|rcsb pdb:5NRL|rcsb pdb:5ZWM|rcsb pdb:5ZWO|rcsb pdb:7B9V	refseq:NP_015111.1|sgd:S000006134|dip:DIP-2399N|mint:Q08963|ensemblfungi:YPL213W(gene)|ensemblfungi:YPL213W_mRNA(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005686"(U2 snRNP)|go:"GO:0005737"(cytoplasm)|go:"GO:0030620"(U2 snRNA binding)|go:"GO:0071004"(U2-type prespliceosome)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003603(U2A'/phosphoprotein 32 family A, C-terminal)|interpro:IPR032675|interpro:IPR044640|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5MQ0|rcsb pdb:5NRL|rcsb pdb:5WSG|rcsb pdb:5Y88|rcsb pdb:5YLZ|rcsb pdb:5ZWM|rcsb pdb:5ZWO|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:6G90|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q	-	crc64:DFAF7E3B7168D944	-	figure legend:Fig 1, Extended Data Fig 2,3, Extended Data Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/12/25	2020/12/25	rogid:2bNoVkou3QatkNCtPIiSdvPdgEo559292	rogid:PlKwD+gRYbhUBE4GcxTaP0wt8zM559292	rigid:V4V9H2k5pPRmMkGb5ANtQTn8GUw	false	-	-	2	1	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P32639	uniprotkb:Q12330	intact:EBI-861|uniprotkb:D3DM80|ensemblfungi:YER172C	intact:EBI-16359|uniprotkb:D6W2L6|ensemblfungi:YOR159C	psi-mi:brr2_yeast(display_long)|uniprotkb:BRR2(gene name)|psi-mi:BRR2(display_short)|uniprotkb:RSS1(gene name synonym)|uniprotkb:SNU246(gene name synonym)|uniprotkb:YER172C(locus name)|uniprotkb:SYGP-ORF66(orf name)|uniprotkb:Protein Snu246(gene name synonym)	psi-mi:ruxe_yeast(display_long)|uniprotkb:SME1(gene name)|psi-mi:SME1(display_short)|uniprotkb:YOR159C(locus name)|uniprotkb:Sm protein E(gene name synonym)	psi-mi:"MI:0410"(3D electron microscopy)	Galej et al. (2016)	imex:IM-28615|pubmed:27459055	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26571711|wwpdb:5LJ5|emdb:EMD-4057|imex:IM-28615-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011099.1|sgd:S000000974|dip:DIP-850N|mint:P32639|ensemblfungi:YER172C(gene)|ensemblfungi:YER172C_mRNA(transcript)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|rcsb pdb:3HIB|rcsb pdb:3IM1|rcsb pdb:3IM2|rcsb pdb:3JCM|rcsb pdb:4BGD|rcsb pdb:5DCA|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GAP|rcsb pdb:5GM6|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5M52|rcsb pdb:5M5P|rcsb pdb:5NRL|rcsb pdb:5ZWM|rcsb pdb:5ZWO|rcsb pdb:7B9V	ensemblfungi:YOR159C(gene)|ensemblfungi:YOR159C_mRNA(transcript)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005682"(U5 snRNP)|go:"GO:0005685"(U1 snRNP)|go:"GO:0005686"(U2 snRNP)|go:"GO:0005687"(U4 snRNP)|go:"GO:0005737"(cytoplasm)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071004"(U2-type prespliceosome)|go:"GO:0071011"(precatalytic spliceosome)|go:"GO:1990935"(splicing factor binding)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR027078|rcsb pdb:3JCM|rcsb pdb:5GAM|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GM6|rcsb pdb:5GMK|sgd:S000005685|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:5NRL|rcsb pdb:5WSG|rcsb pdb:5Y88|rcsb pdb:5YLZ|rcsb pdb:5ZWM|rcsb pdb:5ZWN|rcsb pdb:5ZWO|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:6G90|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q|rcsb pdb:6N7P|rcsb pdb:6N7R|rcsb pdb:6N7X|rcsb pdb:7B9V|refseq:NP_014802.3|dip:DIP-1633N|mint:Q12330	-	crc64:DFAF7E3B7168D944	crc64:B76D72DA8456F3B5	figure legend:Fig 1, Extended Data Fig 2,3, Extended Data Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/12/25	2020/12/25	rogid:2bNoVkou3QatkNCtPIiSdvPdgEo559292	rogid:IiV/AXz4zJjC7A2iuBixxiLYo9E559292	rigid:V4V9H2k5pPRmMkGb5ANtQTn8GUw	false	-	-	2	1	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P32639	uniprotkb:P54999	intact:EBI-861|uniprotkb:D3DM80|ensemblfungi:YER172C	intact:EBI-770|uniprotkb:D6W4I2|ensemblfungi:YPR182W	psi-mi:brr2_yeast(display_long)|uniprotkb:BRR2(gene name)|psi-mi:BRR2(display_short)|uniprotkb:RSS1(gene name synonym)|uniprotkb:SNU246(gene name synonym)|uniprotkb:YER172C(locus name)|uniprotkb:SYGP-ORF66(orf name)|uniprotkb:Protein Snu246(gene name synonym)	psi-mi:ruxf_yeast(display_long)|uniprotkb:SMX3(gene name)|psi-mi:SMX3(display_short)|uniprotkb:YPR182W(locus name)|uniprotkb:P9705.4(orf name)|uniprotkb:Sm protein F(gene name synonym)	psi-mi:"MI:0410"(3D electron microscopy)	Galej et al. (2016)	imex:IM-28615|pubmed:27459055	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26571711|wwpdb:5LJ5|emdb:EMD-4057|imex:IM-28615-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011099.1|sgd:S000000974|dip:DIP-850N|mint:P32639|ensemblfungi:YER172C(gene)|ensemblfungi:YER172C_mRNA(transcript)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|rcsb pdb:3HIB|rcsb pdb:3IM1|rcsb pdb:3IM2|rcsb pdb:3JCM|rcsb pdb:4BGD|rcsb pdb:5DCA|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GAP|rcsb pdb:5GM6|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5M52|rcsb pdb:5M5P|rcsb pdb:5NRL|rcsb pdb:5ZWM|rcsb pdb:5ZWO|rcsb pdb:7B9V	refseq:NP_015508.1|sgd:S000006386|dip:DIP-1634N|mint:P54999|ensemblfungi:YPR182W(gene)|ensemblfungi:YPR182W_mRNA(transcript)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005682"(U5 snRNP)|go:"GO:0005685"(U1 snRNP)|go:"GO:0005686"(U2 snRNP)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1990935"(splicing factor binding)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR016487(Small nuclear ribonucleoprotein SmF)|interpro:IPR034100|rcsb pdb:1N9R|rcsb pdb:1N9S|rcsb pdb:3JCM|rcsb pdb:5GAM|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GM6|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:5NRL|rcsb pdb:5WSG|rcsb pdb:5Y88|rcsb pdb:5YLZ|rcsb pdb:5ZWM|rcsb pdb:5ZWN|rcsb pdb:5ZWO|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:6G90|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q|rcsb pdb:6N7P|rcsb pdb:6N7R|rcsb pdb:6N7X|rcsb pdb:7B9V	-	crc64:DFAF7E3B7168D944	crc64:1640D3237597B2D8	figure legend:Fig 1, Extended Data Fig 2,3, Extended Data Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/12/25	2020/12/25	rogid:2bNoVkou3QatkNCtPIiSdvPdgEo559292	rogid:iyBbVNf2fgOIqhnOg9Etn3P2r3Q559292	rigid:V4V9H2k5pPRmMkGb5ANtQTn8GUw	false	-	-	2	1	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P32639	uniprotkb:P40204	intact:EBI-861|uniprotkb:D3DM80|ensemblfungi:YER172C	intact:EBI-637|uniprotkb:D6VTL2|ensemblfungi:YFL017W-A	psi-mi:brr2_yeast(display_long)|uniprotkb:BRR2(gene name)|psi-mi:BRR2(display_short)|uniprotkb:RSS1(gene name synonym)|uniprotkb:SNU246(gene name synonym)|uniprotkb:YER172C(locus name)|uniprotkb:SYGP-ORF66(orf name)|uniprotkb:Protein Snu246(gene name synonym)	psi-mi:ruxg_yeast(display_long)|uniprotkb:SNP2(gene name synonym)|uniprotkb:YFL017Bw(orf name)|uniprotkb:YFL017W-A(locus name)|uniprotkb:SMX2(gene name)|psi-mi:SMX2(display_short)|uniprotkb:Sm protein G(gene name synonym)	psi-mi:"MI:0410"(3D electron microscopy)	Galej et al. (2016)	imex:IM-28615|pubmed:27459055	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26571711|wwpdb:5LJ5|emdb:EMD-4057|imex:IM-28615-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011099.1|sgd:S000000974|dip:DIP-850N|mint:P32639|ensemblfungi:YER172C(gene)|ensemblfungi:YER172C_mRNA(transcript)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|rcsb pdb:3HIB|rcsb pdb:3IM1|rcsb pdb:3IM2|rcsb pdb:3JCM|rcsb pdb:4BGD|rcsb pdb:5DCA|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GAP|rcsb pdb:5GM6|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5M52|rcsb pdb:5M5P|rcsb pdb:5NRL|rcsb pdb:5ZWM|rcsb pdb:5ZWO|rcsb pdb:7B9V	refseq:NP_116636.1|sgd:S000002965|dip:DIP-6683N|mint:P40204|ensemblfungi:YFL017W-A(gene)|ensemblfungi:YFL017W-A_mRNA(transcript)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005682"(U5 snRNP)|go:"GO:0005685"(U1 snRNP)|go:"GO:0005686"(U2 snRNP)|go:"GO:0005687"(U4 snRNP)|go:"GO:0005689"(U12-type spliceosomal complex)|go:"GO:0034719"(SMN-Sm protein complex)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071004"(U2-type prespliceosome)|go:"GO:0071011"(precatalytic spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0097526"(spliceosomal tri-snRNP complex)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR034098|interpro:IPR044641|rcsb pdb:3JCM|rcsb pdb:5GAM|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GM6|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:5NRL|rcsb pdb:5WSG|rcsb pdb:5Y88|rcsb pdb:5YLZ|rcsb pdb:5ZWM|rcsb pdb:5ZWN|rcsb pdb:5ZWO|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:6G90|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q|rcsb pdb:6N7P|rcsb pdb:6N7R|rcsb pdb:6N7X|rcsb pdb:7B9V|rcsb pdb:7DCO	-	crc64:DFAF7E3B7168D944	crc64:5C6208B8C5A9AB33	figure legend:Fig 1, Extended Data Fig 2,3, Extended Data Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/12/25	2020/12/25	rogid:2bNoVkou3QatkNCtPIiSdvPdgEo559292	rogid:Wh37rGoSJFpJ5o+CuNkBnpiu/5s559292	rigid:V4V9H2k5pPRmMkGb5ANtQTn8GUw	false	-	-	2	1	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P32639	uniprotkb:P38241	intact:EBI-861|uniprotkb:D3DM80|ensemblfungi:YER172C	intact:EBI-780|uniprotkb:P89497|uniprotkb:D6VQ64|ensemblfungi:YBR065C	psi-mi:brr2_yeast(display_long)|uniprotkb:BRR2(gene name)|psi-mi:BRR2(display_short)|uniprotkb:RSS1(gene name synonym)|uniprotkb:SNU246(gene name synonym)|uniprotkb:YER172C(locus name)|uniprotkb:SYGP-ORF66(orf name)|uniprotkb:Protein Snu246(gene name synonym)	psi-mi:slt11_yeast(display_long)|uniprotkb:ECM2(gene name)|psi-mi:ECM2(display_short)|uniprotkb:SLT11(gene name synonym)|uniprotkb:YBR065C(locus name)|uniprotkb:YBR0614(orf name)|uniprotkb:Synthetic lethality with U2 protein 11(gene name synonym)|uniprotkb:Extracellular mutant protein 2(gene name synonym)	psi-mi:"MI:0410"(3D electron microscopy)	Galej et al. (2016)	imex:IM-28615|pubmed:27459055	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26571711|wwpdb:5LJ5|emdb:EMD-4057|imex:IM-28615-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011099.1|sgd:S000000974|dip:DIP-850N|mint:P32639|ensemblfungi:YER172C(gene)|ensemblfungi:YER172C_mRNA(transcript)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|rcsb pdb:3HIB|rcsb pdb:3IM1|rcsb pdb:3IM2|rcsb pdb:3JCM|rcsb pdb:4BGD|rcsb pdb:5DCA|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GAP|rcsb pdb:5GM6|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5M52|rcsb pdb:5M5P|rcsb pdb:5NRL|rcsb pdb:5ZWM|rcsb pdb:5ZWO|rcsb pdb:7B9V	sgd:S000000269|refseq:NP_009621.3|dip:DIP-5359N|mint:P38241|ensemblfungi:YBR065C(gene)|ensemblfungi:YBR065C_mRNA(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000974"(Prp19 complex)|go:"GO:0005634"(nucleus)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0071006"(U2-type catalytic step 1 spliceosome)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|interpro:IPR034356|interpro:IPR039171|rcsb pdb:5GM6|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:5WSG|rcsb pdb:5Y88|rcsb pdb:5YLZ|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q	-	crc64:DFAF7E3B7168D944	crc64:BF21E687817A42B4	figure legend:Fig 1, Extended Data Fig 2,3, Extended Data Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/12/25	2020/12/25	rogid:2bNoVkou3QatkNCtPIiSdvPdgEo559292	rogid:ioGlVp9msutMpWXME0tICQn8GDQ559292	rigid:V4V9H2k5pPRmMkGb5ANtQTn8GUw	false	-	-	2	1	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P32639	uniprotkb:Q02775	intact:EBI-861|uniprotkb:D3DM80|ensemblfungi:YER172C	intact:EBI-17379|uniprotkb:P89902|uniprotkb:Q6Q5U3|uniprotkb:D6VS75|ensemblfungi:YDR088C	psi-mi:brr2_yeast(display_long)|uniprotkb:BRR2(gene name)|psi-mi:BRR2(display_short)|uniprotkb:RSS1(gene name synonym)|uniprotkb:SNU246(gene name synonym)|uniprotkb:YER172C(locus name)|uniprotkb:SYGP-ORF66(orf name)|uniprotkb:Protein Snu246(gene name synonym)	psi-mi:slu7_yeast(display_long)|uniprotkb:SLU7(gene name)|psi-mi:SLU7(display_short)|uniprotkb:YDR088C(locus name)|uniprotkb:D4483(orf name)|uniprotkb:SLT17(gene name synonym)|uniprotkb:Synthetic lethal with U5 snRNA protein 7(gene name synonym)|uniprotkb:Synthetic lethal with U2 snRNA protein 17(gene name synonym)	psi-mi:"MI:0410"(3D electron microscopy)	Galej et al. (2016)	imex:IM-28615|pubmed:27459055	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26571711|wwpdb:5LJ5|emdb:EMD-4057|imex:IM-28615-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011099.1|sgd:S000000974|dip:DIP-850N|mint:P32639|ensemblfungi:YER172C(gene)|ensemblfungi:YER172C_mRNA(transcript)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|rcsb pdb:3HIB|rcsb pdb:3IM1|rcsb pdb:3IM2|rcsb pdb:3JCM|rcsb pdb:4BGD|rcsb pdb:5DCA|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GAP|rcsb pdb:5GM6|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5M52|rcsb pdb:5M5P|rcsb pdb:5NRL|rcsb pdb:5ZWM|rcsb pdb:5ZWO|rcsb pdb:7B9V	refseq:NP_010373.3|sgd:S000002495|ensemblfungi:YDR088C(gene)|ensemblfungi:YDR088C_mRNA(transcript)|go:"GO:0000350"(generation of catalytic spliceosome for second transesterification step)|go:"GO:0000386"(second spliceosomal transesterification activity)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0030628"(pre-mRNA 3'-splice site binding)|go:"GO:0071021"(U2-type post-spliceosomal complex)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR021715|interpro:IPR036875|interpro:IPR039974|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:5YLZ|mint:Q02775|dip:DIP-220N	-	crc64:DFAF7E3B7168D944	crc64:6405458FC367A7D3	figure legend:Fig 1, Extended Data Fig 2,3, Extended Data Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/12/25	2020/12/25	rogid:2bNoVkou3QatkNCtPIiSdvPdgEo559292	rogid:an3IJpPrRlLX0cALtTMg4C2JxUI559292	rigid:V4V9H2k5pPRmMkGb5ANtQTn8GUw	false	-	calmodulin binding peptide plus protein a tag:?-?	2	1	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P32639	uniprotkb:Q02260	intact:EBI-861|uniprotkb:D3DM80|ensemblfungi:YER172C	intact:EBI-585|uniprotkb:D6VUK6|ensemblfungi:YGR074W	psi-mi:brr2_yeast(display_long)|uniprotkb:BRR2(gene name)|psi-mi:BRR2(display_short)|uniprotkb:RSS1(gene name synonym)|uniprotkb:SNU246(gene name synonym)|uniprotkb:YER172C(locus name)|uniprotkb:SYGP-ORF66(orf name)|uniprotkb:Protein Snu246(gene name synonym)	psi-mi:smd1_yeast(display_long)|uniprotkb:YGR074W(locus name)|uniprotkb:SMD1(gene name)|psi-mi:SMD1(display_short)|uniprotkb:snRNP core protein D1(gene name synonym)	psi-mi:"MI:0410"(3D electron microscopy)	Galej et al. (2016)	imex:IM-28615|pubmed:27459055	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26571711|wwpdb:5LJ5|emdb:EMD-4057|imex:IM-28615-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011099.1|sgd:S000000974|dip:DIP-850N|mint:P32639|ensemblfungi:YER172C(gene)|ensemblfungi:YER172C_mRNA(transcript)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|rcsb pdb:3HIB|rcsb pdb:3IM1|rcsb pdb:3IM2|rcsb pdb:3JCM|rcsb pdb:4BGD|rcsb pdb:5DCA|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GAP|rcsb pdb:5GM6|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5M52|rcsb pdb:5M5P|rcsb pdb:5NRL|rcsb pdb:5ZWM|rcsb pdb:5ZWO|rcsb pdb:7B9V	sgd:S000003306|refseq:NP_011588.3|dip:DIP-227N|mint:Q02260|ensemblfungi:YGR074W(gene)|ensemblfungi:YGR074W_mRNA(transcript)|go:"GO:0000243"(commitment complex)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005682"(U5 snRNP)|go:"GO:0005685"(U1 snRNP)|go:"GO:0005686"(U2 snRNP)|go:"GO:0005689"(U12-type spliceosomal complex)|go:"GO:0005829"(cytosol)|go:"GO:0030532"(small nuclear ribonucleoprotein complex)|go:"GO:0034715"(pICln-Sm protein complex)|go:"GO:0005687"(U4 snRNP)|go:"GO:0034719"(SMN-Sm protein complex)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071004"(U2-type prespliceosome)|go:"GO:0071011"(precatalytic spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0097526"(spliceosomal tri-snRNP complex)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR027141|rcsb pdb:3JCM|rcsb pdb:5GAM|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GM6|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:5NRL|rcsb pdb:5WSG|rcsb pdb:5Y88|rcsb pdb:5YLZ|rcsb pdb:5ZWM|rcsb pdb:5ZWN|rcsb pdb:5ZWO|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:6G90|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q|rcsb pdb:6N7P|rcsb pdb:6N7R|rcsb pdb:6N7X|rcsb pdb:7B9V	-	crc64:DFAF7E3B7168D944	crc64:9929F21EB9218447	figure legend:Fig 1, Extended Data Fig 2,3, Extended Data Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/12/25	2020/12/25	rogid:2bNoVkou3QatkNCtPIiSdvPdgEo559292	rogid:SvOKDbY05xgJXKZ8uS+keXsC41I559292	rigid:V4V9H2k5pPRmMkGb5ANtQTn8GUw	false	-	-	2	1	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P32639	uniprotkb:Q06217	intact:EBI-861|uniprotkb:D3DM80|ensemblfungi:YER172C	intact:EBI-235|uniprotkb:D6VYS2|ensemblfungi:YLR275W	psi-mi:brr2_yeast(display_long)|uniprotkb:BRR2(gene name)|psi-mi:BRR2(display_short)|uniprotkb:RSS1(gene name synonym)|uniprotkb:SNU246(gene name synonym)|uniprotkb:YER172C(locus name)|uniprotkb:SYGP-ORF66(orf name)|uniprotkb:Protein Snu246(gene name synonym)	psi-mi:smd2_yeast(display_long)|uniprotkb:SMD2(gene name)|psi-mi:SMD2(display_short)|uniprotkb:YLR275W(locus name)|uniprotkb:L9328.5(orf name)|uniprotkb:snRNP core protein D2(gene name synonym)	psi-mi:"MI:0410"(3D electron microscopy)	Galej et al. (2016)	imex:IM-28615|pubmed:27459055	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26571711|wwpdb:5LJ5|emdb:EMD-4057|imex:IM-28615-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011099.1|sgd:S000000974|dip:DIP-850N|mint:P32639|ensemblfungi:YER172C(gene)|ensemblfungi:YER172C_mRNA(transcript)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|rcsb pdb:3HIB|rcsb pdb:3IM1|rcsb pdb:3IM2|rcsb pdb:3JCM|rcsb pdb:4BGD|rcsb pdb:5DCA|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GAP|rcsb pdb:5GM6|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5M52|rcsb pdb:5M5P|rcsb pdb:5NRL|rcsb pdb:5ZWM|rcsb pdb:5ZWO|rcsb pdb:7B9V	sgd:S000004265|refseq:NP_013377.1|mint:Q06217|dip:DIP-1421N|ensemblfungi:YLR275W(gene)|ensemblfungi:YLR275W_mRNA(transcript)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0003723"(RNA binding)|go:"GO:0005682"(U5 snRNP)|go:"GO:0005685"(U1 snRNP)|go:"GO:0005686"(U2 snRNP)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071004"(U2-type prespliceosome)|go:"GO:0071011"(precatalytic spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR027248|rcsb pdb:3JCM|rcsb pdb:5GAM|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GM6|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:5NRL|rcsb pdb:5WSG|rcsb pdb:5Y88|rcsb pdb:5YLZ|rcsb pdb:5ZWM|rcsb pdb:5ZWN|rcsb pdb:5ZWO|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:6G90|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q|rcsb pdb:6N7P|rcsb pdb:6N7R|rcsb pdb:6N7X|rcsb pdb:7B9V	-	crc64:DFAF7E3B7168D944	crc64:7287070B10E090C0	figure legend:Fig 1, Extended Data Fig 2,3, Extended Data Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/12/25	2020/12/25	rogid:2bNoVkou3QatkNCtPIiSdvPdgEo559292	rogid:rglZ3AQuJfa1rFYIeZLqiYj+L4U559292	rigid:V4V9H2k5pPRmMkGb5ANtQTn8GUw	false	-	-	2	1	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P32639	uniprotkb:P43321	intact:EBI-861|uniprotkb:D3DM80|ensemblfungi:YER172C	intact:EBI-529|ensemblfungi:YLR147C|uniprotkb:D6VYE2|uniprotkb:E9P8W3	psi-mi:brr2_yeast(display_long)|uniprotkb:BRR2(gene name)|psi-mi:BRR2(display_short)|uniprotkb:RSS1(gene name synonym)|uniprotkb:SNU246(gene name synonym)|uniprotkb:YER172C(locus name)|uniprotkb:SYGP-ORF66(orf name)|uniprotkb:Protein Snu246(gene name synonym)	psi-mi:smd3_yeast(display_long)|uniprotkb:SMD3(gene name)|psi-mi:SMD3(display_short)|uniprotkb:YLR147C(locus name)|uniprotkb:L9634.6(orf name)|uniprotkb:snRNP core protein D3(gene name synonym)	psi-mi:"MI:0410"(3D electron microscopy)	Galej et al. (2016)	imex:IM-28615|pubmed:27459055	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26571711|wwpdb:5LJ5|emdb:EMD-4057|imex:IM-28615-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011099.1|sgd:S000000974|dip:DIP-850N|mint:P32639|ensemblfungi:YER172C(gene)|ensemblfungi:YER172C_mRNA(transcript)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|rcsb pdb:3HIB|rcsb pdb:3IM1|rcsb pdb:3IM2|rcsb pdb:3JCM|rcsb pdb:4BGD|rcsb pdb:5DCA|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GAP|rcsb pdb:5GM6|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5M52|rcsb pdb:5M5P|rcsb pdb:5NRL|rcsb pdb:5ZWM|rcsb pdb:5ZWO|rcsb pdb:7B9V	refseq:NP_013248.1|sgd:S000004137|rcsb pdb:5YLZ|rcsb pdb:5ZWM|rcsb pdb:5ZWN|rcsb pdb:5ZWO|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:6G90|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q|rcsb pdb:6N7P|rcsb pdb:6N7R|rcsb pdb:6N7X|rcsb pdb:7B9V|ensemblfungi:YLR147C(gene)|ensemblfungi:YLR147C_mRNA(transcript)|go:"GO:0000243"(commitment complex)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005682"(U5 snRNP)|go:"GO:0005685"(U1 snRNP)|go:"GO:0005686"(U2 snRNP)|go:"GO:0005687"(U4 snRNP)|go:"GO:0005689"(U12-type spliceosomal complex)|go:"GO:0034715"(pICln-Sm protein complex)|go:"GO:0034719"(SMN-Sm protein complex)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071004"(U2-type prespliceosome)|go:"GO:0071011"(precatalytic spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0097526"(spliceosomal tri-snRNP complex)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR027141|interpro:IPR034099|rcsb pdb:3JCM|rcsb pdb:5GAM|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GM6|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:5NRL|rcsb pdb:5WSG|rcsb pdb:5Y88|dip:DIP-715N|mint:P43321	-	crc64:DFAF7E3B7168D944	crc64:BB02A56C5AD70CF2	figure legend:Fig 1, Extended Data Fig 2,3, Extended Data Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/12/25	2020/12/25	rogid:2bNoVkou3QatkNCtPIiSdvPdgEo559292	rogid:ueJ4D76t8ilvz/p9qMzIGiCzqWk559292	rigid:V4V9H2k5pPRmMkGb5ANtQTn8GUw	false	-	-	2	1	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P32639	uniprotkb:P36048	intact:EBI-861|uniprotkb:D3DM80|ensemblfungi:YER172C	intact:EBI-243|uniprotkb:D6VX27|ensemblfungi:YKL173W	psi-mi:brr2_yeast(display_long)|uniprotkb:BRR2(gene name)|psi-mi:BRR2(display_short)|uniprotkb:RSS1(gene name synonym)|uniprotkb:SNU246(gene name synonym)|uniprotkb:YER172C(locus name)|uniprotkb:SYGP-ORF66(orf name)|uniprotkb:Protein Snu246(gene name synonym)	psi-mi:sn114_yeast(display_long)|uniprotkb:GIN10(gene name synonym)|uniprotkb:YKL173W(locus name)|uniprotkb:YKL637(orf name)|uniprotkb:SNU114(gene name)|psi-mi:SNU114(display_short)|uniprotkb:Growth inhibitory protein 10(gene name synonym)|uniprotkb:114 kDa U5 small nuclear ribonucleoprotein component(gene name synonym)	psi-mi:"MI:0410"(3D electron microscopy)	Galej et al. (2016)	imex:IM-28615|pubmed:27459055	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26571711|wwpdb:5LJ5|emdb:EMD-4057|imex:IM-28615-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011099.1|sgd:S000000974|dip:DIP-850N|mint:P32639|ensemblfungi:YER172C(gene)|ensemblfungi:YER172C_mRNA(transcript)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|rcsb pdb:3HIB|rcsb pdb:3IM1|rcsb pdb:3IM2|rcsb pdb:3JCM|rcsb pdb:4BGD|rcsb pdb:5DCA|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GAP|rcsb pdb:5GM6|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5M52|rcsb pdb:5M5P|rcsb pdb:5NRL|rcsb pdb:5ZWM|rcsb pdb:5ZWO|rcsb pdb:7B9V	refseq:NP_012748.1|sgd:S000001656|mint:P36048|dip:DIP-759N|ensemblfungi:YKL173W(gene)|ensemblfungi:YKL173W_mRNA(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000349"(generation of catalytic spliceosome for first transesterification step)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005682"(U5 snRNP)|go:"GO:0030623"(U5 snRNA binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000640(Translation elongation factor EFG/EF2, C-terminal)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR005517(Translation elongation factor EFG/EF2, domain IV)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR020568|interpro:IPR027417|interpro:IPR031950|interpro:IPR035647|interpro:IPR035655|interpro:IPR044121|rcsb pdb:3JCM|rcsb pdb:5GAM|rcsb pdb:5GAN|rcsb pdb:5GM6|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:5NRL|rcsb pdb:5WSG|rcsb pdb:5Y88|rcsb pdb:5YLZ|rcsb pdb:5ZWM|rcsb pdb:5ZWO|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q|rcsb pdb:6TEO	-	crc64:DFAF7E3B7168D944	crc64:5CE30CEFF154D013	figure legend:Fig 1, Extended Data Fig 2,3, Extended Data Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/12/25	2020/12/25	rogid:2bNoVkou3QatkNCtPIiSdvPdgEo559292	rogid:eHDUPadk87+Qb525xpL1tMWb3S4559292	rigid:V4V9H2k5pPRmMkGb5ANtQTn8GUw	false	-	-	2	2	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P32639	uniprotkb:Q06091	intact:EBI-861|uniprotkb:D3DM80|ensemblfungi:YER172C	intact:EBI-818|uniprotkb:D6W499|ensemblfungi:YPR101W	psi-mi:brr2_yeast(display_long)|uniprotkb:BRR2(gene name)|psi-mi:BRR2(display_short)|uniprotkb:RSS1(gene name synonym)|uniprotkb:SNU246(gene name synonym)|uniprotkb:YER172C(locus name)|uniprotkb:SYGP-ORF66(orf name)|uniprotkb:Protein Snu246(gene name synonym)	psi-mi:sn309_yeast(display_long)|uniprotkb:YPR101W(locus name)|uniprotkb:SNT309(gene name)|psi-mi:SNT309(display_short)|uniprotkb:NTC25(gene name synonym)|uniprotkb:Synergistic to PRP19 mutation protein 309(gene name synonym)|uniprotkb:PRP19-associated complex protein 25(gene name synonym)	psi-mi:"MI:0410"(3D electron microscopy)	Galej et al. (2016)	imex:IM-28615|pubmed:27459055	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26571711|wwpdb:5LJ5|emdb:EMD-4057|imex:IM-28615-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011099.1|sgd:S000000974|dip:DIP-850N|mint:P32639|ensemblfungi:YER172C(gene)|ensemblfungi:YER172C_mRNA(transcript)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|rcsb pdb:3HIB|rcsb pdb:3IM1|rcsb pdb:3IM2|rcsb pdb:3JCM|rcsb pdb:4BGD|rcsb pdb:5DCA|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GAP|rcsb pdb:5GM6|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5M52|rcsb pdb:5M5P|rcsb pdb:5NRL|rcsb pdb:5ZWM|rcsb pdb:5ZWO|rcsb pdb:7B9V	sgd:S000006305|refseq:NP_015426.1|dip:DIP-2864N|mint:Q06091|ensemblfungi:YPR101W(gene)|ensemblfungi:YPR101W_mRNA(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000974"(Prp19 complex)|go:"GO:0071006"(U2-type catalytic step 1 spliceosome)|rcsb pdb:5GM6|rcsb pdb:5GMK|rcsb pdb:5LJ5|rcsb pdb:5MQ0|rcsb pdb:5WSG|rcsb pdb:5Y88|rcsb pdb:5YLZ|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q	-	crc64:DFAF7E3B7168D944	crc64:B781CA65BC9A1918	figure legend:Fig 1, Extended Data Fig 2,3, Extended Data Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/12/25	2020/12/25	rogid:2bNoVkou3QatkNCtPIiSdvPdgEo559292	rogid:ELyyYlQDmNRzWKQx/63xvHuAG8M559292	rigid:V4V9H2k5pPRmMkGb5ANtQTn8GUw	false	-	-	2	1	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P32639	uniprotkb:Q04048	intact:EBI-861|uniprotkb:D3DM80|ensemblfungi:YER172C	intact:EBI-540|uniprotkb:D6VT47|ensemblfungi:YDR416W	psi-mi:brr2_yeast(display_long)|uniprotkb:BRR2(gene name)|psi-mi:BRR2(display_short)|uniprotkb:RSS1(gene name synonym)|uniprotkb:SNU246(gene name synonym)|uniprotkb:YER172C(locus name)|uniprotkb:SYGP-ORF66(orf name)|uniprotkb:Protein Snu246(gene name synonym)	psi-mi:syf1_yeast(display_long)|uniprotkb:SYF1(gene name)|psi-mi:SYF1(display_short)|uniprotkb:NTC90(gene name synonym)|uniprotkb:Synthetic lethal with CDC40 protein 1(gene name synonym)|uniprotkb:PRP19-associated complex protein 90(gene name synonym)|uniprotkb:YDR416W(locus name)	psi-mi:"MI:0410"(3D electron microscopy)	Galej et al. (2016)	imex:IM-28615|pubmed:27459055	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26571711|wwpdb:5LJ5|emdb:EMD-4057|imex:IM-28615-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011099.1|sgd:S000000974|dip:DIP-850N|mint:P32639|ensemblfungi:YER172C(gene)|ensemblfungi:YER172C_mRNA(transcript)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|rcsb pdb:3HIB|rcsb pdb:3IM1|rcsb pdb:3IM2|rcsb pdb:3JCM|rcsb pdb:4BGD|rcsb pdb:5DCA|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GAP|rcsb pdb:5GM6|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5M52|rcsb pdb:5M5P|rcsb pdb:5NRL|rcsb pdb:5ZWM|rcsb pdb:5ZWO|rcsb pdb:7B9V	refseq:NP_010704.1|sgd:S000002824|rcsb pdb:5YLZ|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q|reactome:R-SCE-6781823|reactome:R-SCE-6782135|reactome:R-SCE-6782210|rcsb pdb:5Y88|ensemblfungi:YDR416W(gene)|ensemblfungi:YDR416W_mRNA(transcript)|go:"GO:0000349"(generation of catalytic spliceosome for first transesterification step)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000974"(Prp19 complex)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0071004"(U2-type prespliceosome)|go:"GO:0071006"(U2-type catalytic step 1 spliceosome)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071008"(U2-type post-mRNA release spliceosomal complex)|go:"GO:0071014"(post-mRNA release spliceosomal complex)|interpro:IPR003107(RNA-processing protein, HAT helix)|interpro:IPR011990(Tetratricopeptide-like helical)|rcsb pdb:5GM6|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:5WSG|dip:DIP-1681N|mint:Q04048	-	crc64:DFAF7E3B7168D944	crc64:ED4368A624A40E7C	figure legend:Fig 1, Extended Data Fig 2,3, Extended Data Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/12/25	2020/12/25	rogid:2bNoVkou3QatkNCtPIiSdvPdgEo559292	rogid:+1TwiqsQv1IcWxuoIWcJGtTCUFU559292	rigid:V4V9H2k5pPRmMkGb5ANtQTn8GUw	false	-	-	2	1	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P32639	uniprotkb:P28320	intact:EBI-861|uniprotkb:D3DM80|ensemblfungi:YER172C	intact:EBI-26795|uniprotkb:D6VXJ3|ensemblfungi:YKL095W	psi-mi:brr2_yeast(display_long)|uniprotkb:BRR2(gene name)|psi-mi:BRR2(display_short)|uniprotkb:RSS1(gene name synonym)|uniprotkb:SNU246(gene name synonym)|uniprotkb:YER172C(locus name)|uniprotkb:SYGP-ORF66(orf name)|uniprotkb:Protein Snu246(gene name synonym)	psi-mi:yju2_yeast(display_long)|uniprotkb:YKL095W(locus name)|uniprotkb:YKL442(orf name)|uniprotkb:YJU2(gene name)|psi-mi:YJU2(display_short)|uniprotkb:CWC16(gene name synonym)	psi-mi:"MI:0410"(3D electron microscopy)	Galej et al. (2016)	imex:IM-28615|pubmed:27459055	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26571711|wwpdb:5LJ5|emdb:EMD-4057|imex:IM-28615-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011099.1|sgd:S000000974|dip:DIP-850N|mint:P32639|ensemblfungi:YER172C(gene)|ensemblfungi:YER172C_mRNA(transcript)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|rcsb pdb:3HIB|rcsb pdb:3IM1|rcsb pdb:3IM2|rcsb pdb:3JCM|rcsb pdb:4BGD|rcsb pdb:5DCA|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GAP|rcsb pdb:5GM6|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5M52|rcsb pdb:5M5P|rcsb pdb:5NRL|rcsb pdb:5ZWM|rcsb pdb:5ZWO|rcsb pdb:7B9V	refseq:NP_012828.1|sgd:S000001578|mint:P28320|dip:DIP-1915N|ensemblfungi:YKL095W(gene)|ensemblfungi:YKL095W_mRNA(transcript)|go:"GO:0000349"(generation of catalytic spliceosome for first transesterification step)|go:"GO:0000350"(generation of catalytic spliceosome for second transesterification step)|go:"GO:0005634"(nucleus)|go:"GO:0008380"(RNA splicing)|go:"GO:0030620"(U2 snRNA binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0071006"(U2-type catalytic step 1 spliceosome)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|interpro:IPR007590(Protein of unknown function DUF572)|interpro:IPR043701|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5Y88|rcsb pdb:6EXN|rcsb pdb:6J6Q	-	crc64:DFAF7E3B7168D944	crc64:B57F3A173A2113FD	figure legend:Fig 1, Extended Data Fig 2,3, Extended Data Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/12/25	2020/12/25	rogid:2bNoVkou3QatkNCtPIiSdvPdgEo559292	rogid:RB1yjFkujiRVEYwnEtk3x0Beo88559292	rigid:V4V9H2k5pPRmMkGb5ANtQTn8GUw	false	-	-	2	2	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P25337	uniprotkb:Q03654	intact:EBI-547|ensemblfungi:YCR063W|uniprotkb:D6VR67	intact:EBI-476|uniprotkb:Q6B1D8|ensemblfungi:YMR213W|uniprotkb:D6W038	psi-mi:bud31_yeast(display_long)|uniprotkb:BUD31(gene name)|psi-mi:BUD31(display_short)|uniprotkb:Bud site selection protein 31(gene name synonym)|uniprotkb:CWC14(gene name synonym)|uniprotkb:Complexed with CEF1 protein 14(gene name synonym)|uniprotkb:YCR63W(orf name)|uniprotkb:YCR903(orf name)|uniprotkb:YCR063W(locus name)	psi-mi:cef1_yeast(display_long)|uniprotkb:CEF1(gene name)|psi-mi:CEF1(display_short)|uniprotkb:YMR213W(locus name)|uniprotkb:YM8261.07(orf name)|uniprotkb:NTC85(gene name synonym)|uniprotkb:PRP nineteen-associated complex protein 85(gene name synonym)|uniprotkb:PRP19-associated complex protein 85(gene name synonym)	psi-mi:"MI:0410"(3D electron microscopy)	Galej et al. (2016)	imex:IM-28615|pubmed:27459055	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26571742|wwpdb:5LJ3|emdb:EMD-4055|imex:IM-28615-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009990.1|sgd:S000000659|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005686"(U2 snRNP)|interpro:IPR001748(G10 protein)|interpro:IPR018230|rcsb pdb:2MY1|ensemblfungi:YCR063W(gene)|ensemblfungi:YCR063W_mRNA(transcript)|go:"GO:0000282"(cellular bud site selection)|rcsb pdb:5GM6|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:5WSG|rcsb pdb:5Y88|rcsb pdb:5YLZ|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q|dip:DIP-1180N|mint:P25337	refseq:NP_013940.1|sgd:S000004826|ensemblfungi:YMR213W(gene)|ensemblfungi:YMR213W_mRNA(transcript)|go:"GO:0000350"(generation of catalytic spliceosome for second transesterification step)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000974"(Prp19 complex)|go:"GO:0003677"(DNA binding)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0071006"(U2-type catalytic step 1 spliceosome)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017930|interpro:IPR021786|rcsb pdb:5GM6|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:5WSG|rcsb pdb:5Y88|rcsb pdb:5YLZ|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q|rcsb pdb:7DCO|dip:DIP-1113N|mint:Q03654	-	crc64:70A8B15F8DA6F85D	crc64:A4C417A8B330EA9C	figure legend:Fig 1, Extended Data Fig 2,3, Extended Data Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/12/25	2020/12/25	rogid:DImrf7jgUrSuQtfiOvBeJr5Cl/w559292	rogid:AsbV7RtNk+8mCzLk2wZYqbULOFg559292	rigid:CS2BueyjIHJR/Bs/JncMFW0WTkg	false	-	-	1	1	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P25337	uniprotkb:Q12309	intact:EBI-547|ensemblfungi:YCR063W|uniprotkb:D6VR67	intact:EBI-484|uniprotkb:D6VYB5|ensemblfungi:YLR117C	psi-mi:bud31_yeast(display_long)|uniprotkb:BUD31(gene name)|psi-mi:BUD31(display_short)|uniprotkb:Bud site selection protein 31(gene name synonym)|uniprotkb:CWC14(gene name synonym)|uniprotkb:Complexed with CEF1 protein 14(gene name synonym)|uniprotkb:YCR63W(orf name)|uniprotkb:YCR903(orf name)|uniprotkb:YCR063W(locus name)	psi-mi:clf1_yeast(display_long)|uniprotkb:CLF1(gene name)|psi-mi:CLF1(display_short)|uniprotkb:NTC77(gene name synonym)|uniprotkb:YLR117C(locus name)|uniprotkb:SYF3(gene name synonym)|uniprotkb:L2952(orf name)|uniprotkb:Crooked neck-like factor 1(gene name synonym)|uniprotkb:PRP19-associated complex protein 77(gene name synonym)|uniprotkb:Synthetic lethal with CDC40 protein 3(gene name synonym)	psi-mi:"MI:0410"(3D electron microscopy)	Galej et al. (2016)	imex:IM-28615|pubmed:27459055	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26571742|wwpdb:5LJ3|emdb:EMD-4055|imex:IM-28615-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009990.1|sgd:S000000659|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005686"(U2 snRNP)|interpro:IPR001748(G10 protein)|interpro:IPR018230|rcsb pdb:2MY1|ensemblfungi:YCR063W(gene)|ensemblfungi:YCR063W_mRNA(transcript)|go:"GO:0000282"(cellular bud site selection)|rcsb pdb:5GM6|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:5WSG|rcsb pdb:5Y88|rcsb pdb:5YLZ|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q|dip:DIP-1180N|mint:P25337	refseq:NP_013218.1|sgd:S000004107|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q|rcsb pdb:5GM6|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:5WSG|rcsb pdb:5Y88|rcsb pdb:5YLZ|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:6J6G|ensemblfungi:YLR117C(gene)|ensemblfungi:YLR117C_mRNA(transcript)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000354"(cis assembly of pre-catalytic spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000785"(chromatin)|go:"GO:0000974"(Prp19 complex)|go:"GO:0003682"(chromatin binding)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0071004"(U2-type prespliceosome)|go:"GO:0071006"(U2-type catalytic step 1 spliceosome)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071008"(U2-type post-mRNA release spliceosomal complex)|go:"GO:0071014"(post-mRNA release spliceosomal complex)|interpro:IPR003107(RNA-processing protein, HAT helix)|interpro:IPR011990(Tetratricopeptide-like helical)|dip:DIP-1685N|mint:Q12309	-	crc64:70A8B15F8DA6F85D	crc64:AE7D5EC5B3979E00	figure legend:Fig 1, Extended Data Fig 2,3, Extended Data Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/12/25	2020/12/25	rogid:DImrf7jgUrSuQtfiOvBeJr5Cl/w559292	rogid:VbNHO9YGUushIXHTgscFu4xCzC4559292	rigid:CS2BueyjIHJR/Bs/JncMFW0WTkg	false	-	-	1	1	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P25337	uniprotkb:Q03772	intact:EBI-547|ensemblfungi:YCR063W|uniprotkb:D6VR67	intact:EBI-36780|uniprotkb:D6VSE3|ensemblfungi:YDR163W	psi-mi:bud31_yeast(display_long)|uniprotkb:BUD31(gene name)|psi-mi:BUD31(display_short)|uniprotkb:Bud site selection protein 31(gene name synonym)|uniprotkb:CWC14(gene name synonym)|uniprotkb:Complexed with CEF1 protein 14(gene name synonym)|uniprotkb:YCR63W(orf name)|uniprotkb:YCR903(orf name)|uniprotkb:YCR063W(locus name)	psi-mi:cwc15_yeast(display_long)|uniprotkb:CWC15(gene name)|psi-mi:CWC15(display_short)|uniprotkb:Complexed with CEF1 protein 15(gene name synonym)|uniprotkb:YDR163W(locus name)|uniprotkb:YD8358.17(orf name)	psi-mi:"MI:0410"(3D electron microscopy)	Galej et al. (2016)	imex:IM-28615|pubmed:27459055	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26571742|wwpdb:5LJ3|emdb:EMD-4055|imex:IM-28615-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009990.1|sgd:S000000659|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005686"(U2 snRNP)|interpro:IPR001748(G10 protein)|interpro:IPR018230|rcsb pdb:2MY1|ensemblfungi:YCR063W(gene)|ensemblfungi:YCR063W_mRNA(transcript)|go:"GO:0000282"(cellular bud site selection)|rcsb pdb:5GM6|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:5WSG|rcsb pdb:5Y88|rcsb pdb:5YLZ|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q|dip:DIP-1180N|mint:P25337	sgd:S000002570|interpro:IPR006973(Cwf15/Cwc15 cell cycle control protein)|refseq:NP_010447.3|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:5WSG|rcsb pdb:5GM6|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:5Y88|rcsb pdb:5YLZ|ensemblfungi:YDR163W(gene)|ensemblfungi:YDR163W_mRNA(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005684"(U2-type spliceosomal complex)|go:"GO:0045292"(mRNA cis splicing, via spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|rcsb pdb:7DCO	-	crc64:70A8B15F8DA6F85D	-	figure legend:Fig 1, Extended Data Fig 2,3, Extended Data Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/12/25	2020/12/25	rogid:DImrf7jgUrSuQtfiOvBeJr5Cl/w559292	rogid:raWAr5hiD2qEEeUG/lcMNpo1lhM559292	rigid:CS2BueyjIHJR/Bs/JncMFW0WTkg	false	-	-	1	1	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P25337	uniprotkb:Q03375	intact:EBI-547|ensemblfungi:YCR063W|uniprotkb:D6VR67	intact:EBI-30409|uniprotkb:D6VTA5|ensemblfungi:YDR482C	psi-mi:bud31_yeast(display_long)|uniprotkb:BUD31(gene name)|psi-mi:BUD31(display_short)|uniprotkb:Bud site selection protein 31(gene name synonym)|uniprotkb:CWC14(gene name synonym)|uniprotkb:Complexed with CEF1 protein 14(gene name synonym)|uniprotkb:YCR63W(orf name)|uniprotkb:YCR903(orf name)|uniprotkb:YCR063W(locus name)	psi-mi:cwc21_yeast(display_long)|uniprotkb:YDR482C(locus name)|uniprotkb:Complexed with CEF1 protein 21(gene name synonym)|uniprotkb:CWC21(gene name)|psi-mi:CWC21(display_short)	psi-mi:"MI:0410"(3D electron microscopy)	Galej et al. (2016)	imex:IM-28615|pubmed:27459055	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26571742|wwpdb:5LJ3|emdb:EMD-4055|imex:IM-28615-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009990.1|sgd:S000000659|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005686"(U2 snRNP)|interpro:IPR001748(G10 protein)|interpro:IPR018230|rcsb pdb:2MY1|ensemblfungi:YCR063W(gene)|ensemblfungi:YCR063W_mRNA(transcript)|go:"GO:0000282"(cellular bud site selection)|rcsb pdb:5GM6|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:5WSG|rcsb pdb:5Y88|rcsb pdb:5YLZ|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q|dip:DIP-1180N|mint:P25337	sgd:S000002890|refseq:NP_010770.3|dip:DIP-1847N|mint:Q03375|ensemblfungi:YDR482C(gene)|ensemblfungi:YDR482C_mRNA(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005684"(U2-type spliceosomal complex)|go:"GO:0005737"(cytoplasm)|interpro:IPR013170(mRNA splicing factor, Cwf21)|rcsb pdb:5GM6|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:5WSG|rcsb pdb:5YLZ|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q	-	crc64:70A8B15F8DA6F85D	crc64:9723E1C0A393508B	figure legend:Fig 1, Extended Data Fig 2,3, Extended Data Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/12/25	2020/12/25	rogid:DImrf7jgUrSuQtfiOvBeJr5Cl/w559292	rogid:dXmh6RsUTTtGZ8d1CnRgs1Ma+VI559292	rigid:CS2BueyjIHJR/Bs/JncMFW0WTkg	false	-	-	1	1	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P25337	uniprotkb:P53854	intact:EBI-547|ensemblfungi:YCR063W|uniprotkb:D6VR67	intact:EBI-29221|uniprotkb:D6W0U8|ensemblfungi:YNL245C	psi-mi:bud31_yeast(display_long)|uniprotkb:BUD31(gene name)|psi-mi:BUD31(display_short)|uniprotkb:Bud site selection protein 31(gene name synonym)|uniprotkb:CWC14(gene name synonym)|uniprotkb:Complexed with CEF1 protein 14(gene name synonym)|uniprotkb:YCR63W(orf name)|uniprotkb:YCR903(orf name)|uniprotkb:YCR063W(locus name)	psi-mi:cwc25_yeast(display_long)|uniprotkb:Complexed with CEF1 protein 25(gene name synonym)|uniprotkb:YNL245C(locus name)|uniprotkb:N0901(orf name)|uniprotkb:CWC25(gene name)|psi-mi:CWC25(display_short)	psi-mi:"MI:0410"(3D electron microscopy)	Galej et al. (2016)	imex:IM-28615|pubmed:27459055	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26571742|wwpdb:5LJ3|emdb:EMD-4055|imex:IM-28615-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009990.1|sgd:S000000659|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005686"(U2 snRNP)|interpro:IPR001748(G10 protein)|interpro:IPR018230|rcsb pdb:2MY1|ensemblfungi:YCR063W(gene)|ensemblfungi:YCR063W_mRNA(transcript)|go:"GO:0000282"(cellular bud site selection)|rcsb pdb:5GM6|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:5WSG|rcsb pdb:5Y88|rcsb pdb:5YLZ|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q|dip:DIP-1180N|mint:P25337	refseq:NP_014154.1|sgd:S000005189|dip:DIP-2781N|ensemblfungi:YNL245C(gene)|ensemblfungi:YNL245C_mRNA(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005684"(U2-type spliceosomal complex)|interpro:IPR019339|interpro:IPR022209|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5	-	crc64:70A8B15F8DA6F85D	-	figure legend:Fig 1, Extended Data Fig 2,3, Extended Data Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/12/25	2020/12/25	rogid:DImrf7jgUrSuQtfiOvBeJr5Cl/w559292	rogid:6bRgoCHPWEJzKP26V+7zR6CtCMY559292	rigid:CS2BueyjIHJR/Bs/JncMFW0WTkg	false	-	-	1	1	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P25337	uniprotkb:Q12046	intact:EBI-547|ensemblfungi:YCR063W|uniprotkb:D6VR67	intact:EBI-553|ensemblfungi:YDL209C|uniprotkb:D6VRE5	psi-mi:bud31_yeast(display_long)|uniprotkb:BUD31(gene name)|psi-mi:BUD31(display_short)|uniprotkb:Bud site selection protein 31(gene name synonym)|uniprotkb:CWC14(gene name synonym)|uniprotkb:Complexed with CEF1 protein 14(gene name synonym)|uniprotkb:YCR63W(orf name)|uniprotkb:YCR903(orf name)|uniprotkb:YCR063W(locus name)	psi-mi:cwc2_yeast(display_long)|uniprotkb:CWC2(gene name)|psi-mi:CWC2(display_short)|uniprotkb:YDL209C(locus name)|uniprotkb:D1041(orf name)|uniprotkb:NTC40(gene name synonym)|uniprotkb:SLC3(gene name synonym)|uniprotkb:Complexed with CEF1 protein 2(gene name synonym)|uniprotkb:PRP19-associated complex protein 40(gene name synonym)|uniprotkb:Synthetic lethal with CLF1 protein 3(gene name synonym)	psi-mi:"MI:0410"(3D electron microscopy)	Galej et al. (2016)	imex:IM-28615|pubmed:27459055	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26571742|wwpdb:5LJ3|emdb:EMD-4055|imex:IM-28615-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009990.1|sgd:S000000659|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005686"(U2 snRNP)|interpro:IPR001748(G10 protein)|interpro:IPR018230|rcsb pdb:2MY1|ensemblfungi:YCR063W(gene)|ensemblfungi:YCR063W_mRNA(transcript)|go:"GO:0000282"(cellular bud site selection)|rcsb pdb:5GM6|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:5WSG|rcsb pdb:5Y88|rcsb pdb:5YLZ|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q|dip:DIP-1180N|mint:P25337	interpro:IPR000571(Zinc finger, CCCH-type)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR032297|interpro:IPR034181|interpro:IPR035979|interpro:IPR039171|interpro:IPR039173|rcsb pdb:3TP2|rcsb pdb:3U1L|rcsb pdb:3U1M|rcsb pdb:5GM6|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:5WSG|rcsb pdb:5Y88|rcsb pdb:5YLZ|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|refseq:NP_010072.1|sgd:S000002368|ensemblfungi:YDL209C(gene)|ensemblfungi:YDL209C_mRNA(transcript)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000974"(Prp19 complex)|go:"GO:0007049"(cell cycle)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0045292"(mRNA cis splicing, via spliceosome)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0046872"(metal ion binding)|go:"GO:0071006"(U2-type catalytic step 1 spliceosome)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|interpro:IPR000504(RNA recognition motif, RNP-1)|rcsb pdb:6J6Q|dip:DIP-5164N	-	crc64:70A8B15F8DA6F85D	crc64:371734A11DFDB339	figure legend:Fig 1, Extended Data Fig 2,3, Extended Data Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/12/25	2020/12/25	rogid:DImrf7jgUrSuQtfiOvBeJr5Cl/w559292	rogid:bCvRFfQxZ4QaBZqqOyQP7ye/UeQ559292	rigid:CS2BueyjIHJR/Bs/JncMFW0WTkg	false	-	-	1	1	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P25337	uniprotkb:P21374	intact:EBI-547|ensemblfungi:YCR063W|uniprotkb:D6VR67	intact:EBI-9382|ensemblfungi:YJR050W|uniprotkb:D6VWM1	psi-mi:bud31_yeast(display_long)|uniprotkb:BUD31(gene name)|psi-mi:BUD31(display_short)|uniprotkb:Bud site selection protein 31(gene name synonym)|uniprotkb:CWC14(gene name synonym)|uniprotkb:Complexed with CEF1 protein 14(gene name synonym)|uniprotkb:YCR63W(orf name)|uniprotkb:YCR903(orf name)|uniprotkb:YCR063W(locus name)	psi-mi:isy1_yeast(display_long)|uniprotkb:ISY1(gene name)|psi-mi:ISY1(display_short)|uniprotkb:UTR3(gene name synonym)|uniprotkb:YJR050W(locus name)|uniprotkb:J1657(orf name)|uniprotkb:NTC30(gene name synonym)|uniprotkb:Interactor of SYF1(gene name synonym)|uniprotkb:PRP19-associated complex protein 30(gene name synonym)	psi-mi:"MI:0410"(3D electron microscopy)	Galej et al. (2016)	imex:IM-28615|pubmed:27459055	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26571742|wwpdb:5LJ3|emdb:EMD-4055|imex:IM-28615-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009990.1|sgd:S000000659|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005686"(U2 snRNP)|interpro:IPR001748(G10 protein)|interpro:IPR018230|rcsb pdb:2MY1|ensemblfungi:YCR063W(gene)|ensemblfungi:YCR063W_mRNA(transcript)|go:"GO:0000282"(cellular bud site selection)|rcsb pdb:5GM6|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:5WSG|rcsb pdb:5Y88|rcsb pdb:5YLZ|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q|dip:DIP-1180N|mint:P25337	ensemblfungi:YJR050W(gene)|ensemblfungi:YJR050W_mRNA(transcript)|go:"GO:0000350"(generation of catalytic spliceosome for second transesterification step)|go:"GO:0000389"(mRNA 3'-splice site recognition)|go:"GO:0000974"(Prp19 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0071006"(U2-type catalytic step 1 spliceosome)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0071014"(post-mRNA release spliceosomal complex)|go:"GO:0071020"(post-spliceosomal complex)|interpro:IPR009360(Isy1-like splicing)|interpro:IPR029012|interpro:IPR037200|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q|reactome:R-SCE-6781823|reactome:R-SCE-6782135|reactome:R-SCE-6782210|sgd:S000003811|refseq:NP_012584.3|mint:P21374|dip:DIP-1682N	-	crc64:70A8B15F8DA6F85D	-	figure legend:Fig 1, Extended Data Fig 2,3, Extended Data Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/12/25	2020/12/25	rogid:DImrf7jgUrSuQtfiOvBeJr5Cl/w559292	rogid:NHLAtd+wLxwtWQD8PsyzyQsfJOg559292	rigid:CS2BueyjIHJR/Bs/JncMFW0WTkg	false	-	-	1	1	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P25337	uniprotkb:P40567	intact:EBI-547|ensemblfungi:YCR063W|uniprotkb:D6VR67	intact:EBI-789|uniprotkb:D6VVT9|ensemblfungi:YIR009W	psi-mi:bud31_yeast(display_long)|uniprotkb:BUD31(gene name)|psi-mi:BUD31(display_short)|uniprotkb:Bud site selection protein 31(gene name synonym)|uniprotkb:CWC14(gene name synonym)|uniprotkb:Complexed with CEF1 protein 14(gene name synonym)|uniprotkb:YCR63W(orf name)|uniprotkb:YCR903(orf name)|uniprotkb:YCR063W(locus name)	psi-mi:msl1_yeast(display_long)|uniprotkb:YIB9W(orf name)|uniprotkb:YIR009W(locus name)|uniprotkb:MSL1(gene name)|psi-mi:MSL1(display_short)	psi-mi:"MI:0410"(3D electron microscopy)	Galej et al. (2016)	imex:IM-28615|pubmed:27459055	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26571742|wwpdb:5LJ3|emdb:EMD-4055|imex:IM-28615-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009990.1|sgd:S000000659|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005686"(U2 snRNP)|interpro:IPR001748(G10 protein)|interpro:IPR018230|rcsb pdb:2MY1|ensemblfungi:YCR063W(gene)|ensemblfungi:YCR063W_mRNA(transcript)|go:"GO:0000282"(cellular bud site selection)|rcsb pdb:5GM6|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:5WSG|rcsb pdb:5Y88|rcsb pdb:5YLZ|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q|dip:DIP-1180N|mint:P25337	refseq:NP_012274.1|sgd:S000001448|rcsb pdb:6BK8|ensemblfungi:YIR009W(gene)|ensemblfungi:YIR009W_mRNA(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005685"(U1 snRNP)|go:"GO:0030619"(U1 snRNA binding)|go:"GO:0030620"(U2 snRNA binding)|go:"GO:0071004"(U2-type prespliceosome)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5MQ0|rcsb pdb:5NRL|rcsb pdb:5WSG|rcsb pdb:5Y88|rcsb pdb:5YLZ|rcsb pdb:5ZWM|rcsb pdb:5ZWO|dip:DIP-816N|mint:P40567|rcsb pdb:6EXN|rcsb pdb:6G90|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q	-	crc64:70A8B15F8DA6F85D	-	figure legend:Fig 1, Extended Data Fig 2,3, Extended Data Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/12/25	2020/12/25	rogid:DImrf7jgUrSuQtfiOvBeJr5Cl/w559292	rogid:GAiHZKcbfNjbem3+i1cZXFm4NfE559292	rigid:CS2BueyjIHJR/Bs/JncMFW0WTkg	false	-	-	1	1	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P25337	uniprotkb:P33411	intact:EBI-547|ensemblfungi:YCR063W|uniprotkb:D6VR67	intact:EBI-13844|uniprotkb:Q02459|uniprotkb:Q05724|ensemblfungi:YGR006W|uniprotkb:D6VUE3	psi-mi:bud31_yeast(display_long)|uniprotkb:BUD31(gene name)|psi-mi:BUD31(display_short)|uniprotkb:Bud site selection protein 31(gene name synonym)|uniprotkb:CWC14(gene name synonym)|uniprotkb:Complexed with CEF1 protein 14(gene name synonym)|uniprotkb:YCR63W(orf name)|uniprotkb:YCR903(orf name)|uniprotkb:YCR063W(locus name)	psi-mi:prp18_yeast(display_long)|uniprotkb:PRP18(gene name)|psi-mi:PRP18(display_short)|uniprotkb:YGR006W(locus name)	psi-mi:"MI:0410"(3D electron microscopy)	Galej et al. (2016)	imex:IM-28615|pubmed:27459055	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26571742|wwpdb:5LJ3|emdb:EMD-4055|imex:IM-28615-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009990.1|sgd:S000000659|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005686"(U2 snRNP)|interpro:IPR001748(G10 protein)|interpro:IPR018230|rcsb pdb:2MY1|ensemblfungi:YCR063W(gene)|ensemblfungi:YCR063W_mRNA(transcript)|go:"GO:0000282"(cellular bud site selection)|rcsb pdb:5GM6|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:5WSG|rcsb pdb:5Y88|rcsb pdb:5YLZ|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q|dip:DIP-1180N|mint:P25337	ensemblfungi:YGR006W(gene)|ensemblfungi:YGR006W_mRNA(transcript)|go:"GO:0000350"(generation of catalytic spliceosome for second transesterification step)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005682"(U5 snRNP)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071021"(U2-type post-spliceosomal complex)|go:"GO:0071048"|interpro:IPR004098(Prp18)|interpro:IPR039979|rcsb pdb:1DVK|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:5WSG|rcsb pdb:5YLZ|rcsb pdb:6BK8|rcsb pdb:6EXN|refseq:NP_011520.2|sgd:S000003238|mint:P33411|dip:DIP-1110N	-	crc64:70A8B15F8DA6F85D	-	figure legend:Fig 1, Extended Data Fig 2,3, Extended Data Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/12/25	2020/12/25	rogid:DImrf7jgUrSuQtfiOvBeJr5Cl/w559292	rogid:3OaVOaHslViUjLZSTUDVIVMo4WY559292	rigid:CS2BueyjIHJR/Bs/JncMFW0WTkg	false	-	ha tag:?-?	1	1	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P25337	uniprotkb:P28004	intact:EBI-547|ensemblfungi:YCR063W|uniprotkb:D6VR67	intact:EBI-20640|uniprotkb:D6VPI6|ensemblfungi:YAL032C	psi-mi:bud31_yeast(display_long)|uniprotkb:BUD31(gene name)|psi-mi:BUD31(display_short)|uniprotkb:Bud site selection protein 31(gene name synonym)|uniprotkb:CWC14(gene name synonym)|uniprotkb:Complexed with CEF1 protein 14(gene name synonym)|uniprotkb:YCR63W(orf name)|uniprotkb:YCR903(orf name)|uniprotkb:YCR063W(locus name)	psi-mi:prp45_yeast(display_long)|uniprotkb:YAL032C(locus name)|uniprotkb:PRP45(gene name)|psi-mi:PRP45(display_short)|uniprotkb:FUN20(gene name synonym)	psi-mi:"MI:0410"(3D electron microscopy)	Galej et al. (2016)	imex:IM-28615|pubmed:27459055	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26571742|wwpdb:5LJ3|emdb:EMD-4055|imex:IM-28615-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009990.1|sgd:S000000659|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005686"(U2 snRNP)|interpro:IPR001748(G10 protein)|interpro:IPR018230|rcsb pdb:2MY1|ensemblfungi:YCR063W(gene)|ensemblfungi:YCR063W_mRNA(transcript)|go:"GO:0000282"(cellular bud site selection)|rcsb pdb:5GM6|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:5WSG|rcsb pdb:5Y88|rcsb pdb:5YLZ|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q|dip:DIP-1180N|mint:P25337	refseq:NP_009370.1|sgd:S000000030|ensemblfungi:YAL032C(gene)|ensemblfungi:YAL032C_mRNA(transcript)|go:"GO:0000350"(generation of catalytic spliceosome for second transesterification step)|go:"GO:0005634"(nucleus)|go:"GO:0071006"(U2-type catalytic step 1 spliceosome)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071014"(post-mRNA release spliceosomal complex)|interpro:IPR004015(SKIP/SNW)|interpro:IPR017862|rcsb pdb:5GM6|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:5WSG|rcsb pdb:5Y88|rcsb pdb:5YLZ|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q|dip:DIP-2774N|mint:P28004	-	crc64:70A8B15F8DA6F85D	crc64:FE5A724186D7FE84	figure legend:Fig 1, Extended Data Fig 2,3, Extended Data Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/12/25	2020/12/25	rogid:DImrf7jgUrSuQtfiOvBeJr5Cl/w559292	rogid:qoHF1UsO3k+JOTOfigSuy2P84/k559292	rigid:CS2BueyjIHJR/Bs/JncMFW0WTkg	false	-	-	1	1	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P25337	uniprotkb:Q12417	intact:EBI-547|ensemblfungi:YCR063W|uniprotkb:D6VR67	intact:EBI-710|uniprotkb:D6W3L8|ensemblfungi:YPL151C	psi-mi:bud31_yeast(display_long)|uniprotkb:BUD31(gene name)|psi-mi:BUD31(display_short)|uniprotkb:Bud site selection protein 31(gene name synonym)|uniprotkb:CWC14(gene name synonym)|uniprotkb:Complexed with CEF1 protein 14(gene name synonym)|uniprotkb:YCR63W(orf name)|uniprotkb:YCR903(orf name)|uniprotkb:YCR063W(locus name)	psi-mi:prp46_yeast(display_long)|uniprotkb:CWC1(gene name synonym)|uniprotkb:PRP nineteen-associated complex protein 50(gene name synonym)|uniprotkb:PRP19-associated complex protein 50(gene name synonym)|uniprotkb:P2594(orf name)|uniprotkb:YPL151C(locus name)|uniprotkb:PRP46(gene name)|psi-mi:PRP46(display_short)|uniprotkb:NTC50(gene name synonym)|uniprotkb:Pre-mRNA-processing protein 46(gene name synonym)|uniprotkb:Complexed with CEF1 protein 1(gene name synonym)	psi-mi:"MI:0410"(3D electron microscopy)	Galej et al. (2016)	imex:IM-28615|pubmed:27459055	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26571742|wwpdb:5LJ3|emdb:EMD-4055|imex:IM-28615-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009990.1|sgd:S000000659|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005686"(U2 snRNP)|interpro:IPR001748(G10 protein)|interpro:IPR018230|rcsb pdb:2MY1|ensemblfungi:YCR063W(gene)|ensemblfungi:YCR063W_mRNA(transcript)|go:"GO:0000282"(cellular bud site selection)|rcsb pdb:5GM6|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:5WSG|rcsb pdb:5Y88|rcsb pdb:5YLZ|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q|dip:DIP-1180N|mint:P25337	refseq:NP_015174.1|sgd:S000006072|ensemblfungi:YPL151C(gene)|ensemblfungi:YPL151C_mRNA(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000974"(Prp19 complex)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|dip:DIP-3994N|mint:Q12417|rcsb pdb:5GM6|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:5WSG|rcsb pdb:5Y88|rcsb pdb:5YLZ|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q	-	crc64:70A8B15F8DA6F85D	crc64:0E888F566A5414BD	figure legend:Fig 1, Extended Data Fig 2,3, Extended Data Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/12/25	2020/12/25	rogid:DImrf7jgUrSuQtfiOvBeJr5Cl/w559292	rogid:016ynVER9V3d44NwkqRG7TIvf9w559292	rigid:CS2BueyjIHJR/Bs/JncMFW0WTkg	false	-	-	1	1	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P25337	uniprotkb:P33334	intact:EBI-547|ensemblfungi:YCR063W|uniprotkb:D6VR67	intact:EBI-465|uniprotkb:D3DLB4|ensemblfungi:YHR165C	psi-mi:bud31_yeast(display_long)|uniprotkb:BUD31(gene name)|psi-mi:BUD31(display_short)|uniprotkb:Bud site selection protein 31(gene name synonym)|uniprotkb:CWC14(gene name synonym)|uniprotkb:Complexed with CEF1 protein 14(gene name synonym)|uniprotkb:YCR63W(orf name)|uniprotkb:YCR903(orf name)|uniprotkb:YCR063W(locus name)	psi-mi:prp8_yeast(display_long)|uniprotkb:PRP8(gene name)|psi-mi:PRP8(display_short)|uniprotkb:DBF3(gene name synonym)|uniprotkb:DNA39(gene name synonym)|uniprotkb:RNA8(gene name synonym)|uniprotkb:SLT21(gene name synonym)|uniprotkb:USA2(gene name synonym)|uniprotkb:YHR165C(locus name)	psi-mi:"MI:0410"(3D electron microscopy)	Galej et al. (2016)	imex:IM-28615|pubmed:27459055	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26571742|wwpdb:5LJ3|emdb:EMD-4055|imex:IM-28615-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009990.1|sgd:S000000659|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005686"(U2 snRNP)|interpro:IPR001748(G10 protein)|interpro:IPR018230|rcsb pdb:2MY1|ensemblfungi:YCR063W(gene)|ensemblfungi:YCR063W_mRNA(transcript)|go:"GO:0000282"(cellular bud site selection)|rcsb pdb:5GM6|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:5WSG|rcsb pdb:5Y88|rcsb pdb:5YLZ|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q|dip:DIP-1180N|mint:P25337	refseq:NP_012035.1|sgd:S000001208|rcsb pdb:4ILJ|rcsb pdb:5DCA|rcsb pdb:5GAM|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GAP|rcsb pdb:5GM6|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5M52|rcsb pdb:5M5P|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:5NRL|rcsb pdb:5QY1|rcsb pdb:5QY2|rcsb pdb:5QY3|rcsb pdb:5QY4|rcsb pdb:5QY5|rcsb pdb:5QY6|rcsb pdb:5QY7|rcsb pdb:5QY8|rcsb pdb:5QY9|rcsb pdb:5QYA|rcsb pdb:5QYB|rcsb pdb:5QYC|rcsb pdb:5QYD|rcsb pdb:5QYE|rcsb pdb:5QYF|rcsb pdb:5QYG|rcsb pdb:5QYH|rcsb pdb:5QYI|rcsb pdb:5QYJ|rcsb pdb:5QYK|rcsb pdb:5QYL|rcsb pdb:5QYM|rcsb pdb:5QYN|rcsb pdb:5QYO|rcsb pdb:5QYP|rcsb pdb:5QYQ|rcsb pdb:5QYR|rcsb pdb:5QYS|rcsb pdb:5QYT|rcsb pdb:5QYU|rcsb pdb:5QYV|rcsb pdb:5QYW|rcsb pdb:5QYX|rcsb pdb:5QYY|rcsb pdb:5QYZ|rcsb pdb:5QZ0|rcsb pdb:5QZ1|rcsb pdb:5QZ2|rcsb pdb:5QZ3|rcsb pdb:5QZ4|rcsb pdb:5QZ5|rcsb pdb:5QZ6|rcsb pdb:5QZ7|rcsb pdb:5QZ8|rcsb pdb:5QZ9|rcsb pdb:5QZA|rcsb pdb:5QZB|rcsb pdb:5QZC|rcsb pdb:5QZD|rcsb pdb:5QZE|rcsb pdb:5QZF|rcsb pdb:5QZG|rcsb pdb:5QZH|rcsb pdb:5QZI|rcsb pdb:5QZJ|rcsb pdb:5QZK|rcsb pdb:5QZL|rcsb pdb:5QZM|rcsb pdb:5QZN|rcsb pdb:5QZO|rcsb pdb:5QZP|rcsb pdb:5R14|rcsb pdb:5R15|rcsb pdb:5R16|rcsb pdb:5R17|rcsb pdb:5R18|rcsb pdb:5R19|rcsb pdb:5R1A|rcsb pdb:5R1B|rcsb pdb:5R1C|rcsb pdb:5R1D|rcsb pdb:5R1E|rcsb pdb:5R1F|rcsb pdb:5R1G|rcsb pdb:5R1H|rcsb pdb:5R1I|rcsb pdb:5R1J|rcsb pdb:5R1K|rcsb pdb:5R1L|rcsb pdb:5R1M|rcsb pdb:5R1N|rcsb pdb:5R1O|rcsb pdb:5R1P|rcsb pdb:5R1Q|rcsb pdb:5R1S|rcsb pdb:5WSG|rcsb pdb:5Y88|rcsb pdb:5YLZ|rcsb pdb:5ZWM|rcsb pdb:5ZWO|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q|rcsb pdb:6TEO|rcsb pdb:7B9V|rcsb pdb:5QZQ|rcsb pdb:5QZR|rcsb pdb:5QZS|rcsb pdb:5QZT|rcsb pdb:5QZU|rcsb pdb:5QZV|rcsb pdb:5QZW|rcsb pdb:5QZX|rcsb pdb:5QZY|rcsb pdb:5QZZ|rcsb pdb:5R00|rcsb pdb:5R01|rcsb pdb:5R02|rcsb pdb:5R03|rcsb pdb:5R04|rcsb pdb:5R05|rcsb pdb:5R06|rcsb pdb:5R07|rcsb pdb:5R08|rcsb pdb:5R09|rcsb pdb:5R0A|rcsb pdb:5R0B|rcsb pdb:5R0C|rcsb pdb:5R0D|rcsb pdb:5R0E|rcsb pdb:5R0F|rcsb pdb:5R0G|rcsb pdb:5R0H|rcsb pdb:5R0I|rcsb pdb:5R0J|rcsb pdb:5R0K|rcsb pdb:5R0L|rcsb pdb:5R0M|rcsb pdb:5R0N|rcsb pdb:5R0O|rcsb pdb:5R0P|rcsb pdb:5R0Q|rcsb pdb:5R0R|rcsb pdb:5R0S|rcsb pdb:5R0T|rcsb pdb:5R0U|rcsb pdb:5R0V|rcsb pdb:5R0W|rcsb pdb:5R0X|rcsb pdb:5R0Y|rcsb pdb:5R0Z|rcsb pdb:5R10|rcsb pdb:5R11|rcsb pdb:5R12|rcsb pdb:5R13|ensemblfungi:YHR165C(gene)|ensemblfungi:YHR165C_mRNA(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000350"(generation of catalytic spliceosome for second transesterification step)|go:"GO:0000389"(mRNA 3'-splice site recognition)|go:"GO:0000395"(mRNA 5'-splice site recognition)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005682"(U5 snRNP)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0030619"(U1 snRNA binding)|go:"GO:0030620"(U2 snRNA binding)|go:"GO:0030623"(U5 snRNA binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0071013"(catalytic step 2 spliceosome)|rcsb pdb:3SBT|rcsb pdb:3ZEF|rcsb pdb:4BGD|rcsb pdb:4I43|go:"GO:0097157"(pre-mRNA intronic binding)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR012591(PRO8NT)|interpro:IPR012592(PROCN)|interpro:IPR012984(PRO, C-terminal)|interpro:IPR019580|interpro:IPR019581|interpro:IPR019582|interpro:IPR021983|interpro:IPR027652|interpro:IPR037518|interpro:IPR042516|interpro:IPR043172|interpro:IPR043173|rcsb pdb:2OG4|rcsb pdb:3E66|rcsb pdb:3E9O|rcsb pdb:3E9P|rcsb pdb:3JCM|rcsb pdb:3SBG|rcsb pdb:4ILG|rcsb pdb:4ILH|dip:DIP-2427N|mint:P33334	-	crc64:70A8B15F8DA6F85D	crc64:8F4F6F89D34D3508	figure legend:Fig 1, Extended Data Fig 2,3, Extended Data Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/12/25	2020/12/25	rogid:DImrf7jgUrSuQtfiOvBeJr5Cl/w559292	rogid:0JoVp7ULlbib7N5+GOPksHStSmY559292	rigid:CS2BueyjIHJR/Bs/JncMFW0WTkg	false	-	-	1	1	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P25337	uniprotkb:P40018	intact:EBI-547|ensemblfungi:YCR063W|uniprotkb:D6VR67	intact:EBI-432|uniprotkb:D3DLS8|ensemblfungi:YER029C	psi-mi:bud31_yeast(display_long)|uniprotkb:BUD31(gene name)|psi-mi:BUD31(display_short)|uniprotkb:Bud site selection protein 31(gene name synonym)|uniprotkb:CWC14(gene name synonym)|uniprotkb:Complexed with CEF1 protein 14(gene name synonym)|uniprotkb:YCR63W(orf name)|uniprotkb:YCR903(orf name)|uniprotkb:YCR063W(locus name)	psi-mi:rsmb_yeast(display_long)|uniprotkb:SMB1(gene name)|psi-mi:SMB1(display_short)|uniprotkb:Sm protein B(gene name synonym)|uniprotkb:YER029C(locus name)	psi-mi:"MI:0410"(3D electron microscopy)	Galej et al. (2016)	imex:IM-28615|pubmed:27459055	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26571742|wwpdb:5LJ3|emdb:EMD-4055|imex:IM-28615-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009990.1|sgd:S000000659|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005686"(U2 snRNP)|interpro:IPR001748(G10 protein)|interpro:IPR018230|rcsb pdb:2MY1|ensemblfungi:YCR063W(gene)|ensemblfungi:YCR063W_mRNA(transcript)|go:"GO:0000282"(cellular bud site selection)|rcsb pdb:5GM6|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:5WSG|rcsb pdb:5Y88|rcsb pdb:5YLZ|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q|dip:DIP-1180N|mint:P25337	sgd:S000000831|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:5NRL|rcsb pdb:5WSG|rcsb pdb:5Y88|rcsb pdb:5YLZ|rcsb pdb:5ZWM|rcsb pdb:5ZWN|rcsb pdb:5ZWO|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:6G90|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q|rcsb pdb:6N7P|rcsb pdb:6N7R|rcsb pdb:6N7X|rcsb pdb:7B9V|ensemblfungi:YER029C(gene)|ensemblfungi:YER029C_mRNA(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005682"(U5 snRNP)|go:"GO:0005685"(U1 snRNP)|go:"GO:0005686"(U2 snRNP)|go:"GO:0005687"(U4 snRNP)|go:"GO:0005737"(cytoplasm)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071004"(U2-type prespliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|rcsb pdb:3JCM|rcsb pdb:5GAM|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GM6|refseq:NP_010946.3|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5LQW|dip:DIP-843N|mint:P40018	-	crc64:70A8B15F8DA6F85D	crc64:0A1078D5AA241430	figure legend:Fig 1, Extended Data Fig 2,3, Extended Data Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/12/25	2020/12/25	rogid:DImrf7jgUrSuQtfiOvBeJr5Cl/w559292	rogid:b62+dBOdvQgeE0oup4kbXbviS1U559292	rigid:CS2BueyjIHJR/Bs/JncMFW0WTkg	false	-	-	1	1	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P25337	uniprotkb:Q08963	intact:EBI-547|ensemblfungi:YCR063W|uniprotkb:D6VR67	intact:EBI-594|uniprotkb:D6W3F7|ensemblfungi:YPL213W	psi-mi:bud31_yeast(display_long)|uniprotkb:BUD31(gene name)|psi-mi:BUD31(display_short)|uniprotkb:Bud site selection protein 31(gene name synonym)|uniprotkb:CWC14(gene name synonym)|uniprotkb:Complexed with CEF1 protein 14(gene name synonym)|uniprotkb:YCR63W(orf name)|uniprotkb:YCR903(orf name)|uniprotkb:YCR063W(locus name)	psi-mi:ru2a_yeast(display_long)|uniprotkb:YPL213W(locus name)|uniprotkb:LEA1(gene name)|psi-mi:LEA1(display_short)|uniprotkb:Looks exceptionally like U2A protein 1(gene name synonym)	psi-mi:"MI:0410"(3D electron microscopy)	Galej et al. (2016)	imex:IM-28615|pubmed:27459055	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26571742|wwpdb:5LJ3|emdb:EMD-4055|imex:IM-28615-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009990.1|sgd:S000000659|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005686"(U2 snRNP)|interpro:IPR001748(G10 protein)|interpro:IPR018230|rcsb pdb:2MY1|ensemblfungi:YCR063W(gene)|ensemblfungi:YCR063W_mRNA(transcript)|go:"GO:0000282"(cellular bud site selection)|rcsb pdb:5GM6|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:5WSG|rcsb pdb:5Y88|rcsb pdb:5YLZ|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q|dip:DIP-1180N|mint:P25337	refseq:NP_015111.1|sgd:S000006134|dip:DIP-2399N|mint:Q08963|ensemblfungi:YPL213W(gene)|ensemblfungi:YPL213W_mRNA(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005686"(U2 snRNP)|go:"GO:0005737"(cytoplasm)|go:"GO:0030620"(U2 snRNA binding)|go:"GO:0071004"(U2-type prespliceosome)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003603(U2A'/phosphoprotein 32 family A, C-terminal)|interpro:IPR032675|interpro:IPR044640|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5MQ0|rcsb pdb:5NRL|rcsb pdb:5WSG|rcsb pdb:5Y88|rcsb pdb:5YLZ|rcsb pdb:5ZWM|rcsb pdb:5ZWO|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:6G90|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q	-	crc64:70A8B15F8DA6F85D	-	figure legend:Fig 1, Extended Data Fig 2,3, Extended Data Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/12/25	2020/12/25	rogid:DImrf7jgUrSuQtfiOvBeJr5Cl/w559292	rogid:PlKwD+gRYbhUBE4GcxTaP0wt8zM559292	rigid:CS2BueyjIHJR/Bs/JncMFW0WTkg	false	-	-	1	1	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P25337	uniprotkb:Q12330	intact:EBI-547|ensemblfungi:YCR063W|uniprotkb:D6VR67	intact:EBI-16359|uniprotkb:D6W2L6|ensemblfungi:YOR159C	psi-mi:bud31_yeast(display_long)|uniprotkb:BUD31(gene name)|psi-mi:BUD31(display_short)|uniprotkb:Bud site selection protein 31(gene name synonym)|uniprotkb:CWC14(gene name synonym)|uniprotkb:Complexed with CEF1 protein 14(gene name synonym)|uniprotkb:YCR63W(orf name)|uniprotkb:YCR903(orf name)|uniprotkb:YCR063W(locus name)	psi-mi:ruxe_yeast(display_long)|uniprotkb:SME1(gene name)|psi-mi:SME1(display_short)|uniprotkb:YOR159C(locus name)|uniprotkb:Sm protein E(gene name synonym)	psi-mi:"MI:0410"(3D electron microscopy)	Galej et al. (2016)	imex:IM-28615|pubmed:27459055	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26571742|wwpdb:5LJ3|emdb:EMD-4055|imex:IM-28615-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009990.1|sgd:S000000659|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005686"(U2 snRNP)|interpro:IPR001748(G10 protein)|interpro:IPR018230|rcsb pdb:2MY1|ensemblfungi:YCR063W(gene)|ensemblfungi:YCR063W_mRNA(transcript)|go:"GO:0000282"(cellular bud site selection)|rcsb pdb:5GM6|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:5WSG|rcsb pdb:5Y88|rcsb pdb:5YLZ|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q|dip:DIP-1180N|mint:P25337	ensemblfungi:YOR159C(gene)|ensemblfungi:YOR159C_mRNA(transcript)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005682"(U5 snRNP)|go:"GO:0005685"(U1 snRNP)|go:"GO:0005686"(U2 snRNP)|go:"GO:0005687"(U4 snRNP)|go:"GO:0005737"(cytoplasm)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071004"(U2-type prespliceosome)|go:"GO:0071011"(precatalytic spliceosome)|go:"GO:1990935"(splicing factor binding)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR027078|rcsb pdb:3JCM|rcsb pdb:5GAM|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GM6|rcsb pdb:5GMK|sgd:S000005685|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:5NRL|rcsb pdb:5WSG|rcsb pdb:5Y88|rcsb pdb:5YLZ|rcsb pdb:5ZWM|rcsb pdb:5ZWN|rcsb pdb:5ZWO|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:6G90|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q|rcsb pdb:6N7P|rcsb pdb:6N7R|rcsb pdb:6N7X|rcsb pdb:7B9V|refseq:NP_014802.3|dip:DIP-1633N|mint:Q12330	-	crc64:70A8B15F8DA6F85D	crc64:B76D72DA8456F3B5	figure legend:Fig 1, Extended Data Fig 2,3, Extended Data Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/12/25	2020/12/25	rogid:DImrf7jgUrSuQtfiOvBeJr5Cl/w559292	rogid:IiV/AXz4zJjC7A2iuBixxiLYo9E559292	rigid:CS2BueyjIHJR/Bs/JncMFW0WTkg	false	-	-	1	1	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P25337	uniprotkb:P54999	intact:EBI-547|ensemblfungi:YCR063W|uniprotkb:D6VR67	intact:EBI-770|uniprotkb:D6W4I2|ensemblfungi:YPR182W	psi-mi:bud31_yeast(display_long)|uniprotkb:BUD31(gene name)|psi-mi:BUD31(display_short)|uniprotkb:Bud site selection protein 31(gene name synonym)|uniprotkb:CWC14(gene name synonym)|uniprotkb:Complexed with CEF1 protein 14(gene name synonym)|uniprotkb:YCR63W(orf name)|uniprotkb:YCR903(orf name)|uniprotkb:YCR063W(locus name)	psi-mi:ruxf_yeast(display_long)|uniprotkb:SMX3(gene name)|psi-mi:SMX3(display_short)|uniprotkb:YPR182W(locus name)|uniprotkb:P9705.4(orf name)|uniprotkb:Sm protein F(gene name synonym)	psi-mi:"MI:0410"(3D electron microscopy)	Galej et al. (2016)	imex:IM-28615|pubmed:27459055	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26571742|wwpdb:5LJ3|emdb:EMD-4055|imex:IM-28615-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009990.1|sgd:S000000659|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005686"(U2 snRNP)|interpro:IPR001748(G10 protein)|interpro:IPR018230|rcsb pdb:2MY1|ensemblfungi:YCR063W(gene)|ensemblfungi:YCR063W_mRNA(transcript)|go:"GO:0000282"(cellular bud site selection)|rcsb pdb:5GM6|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:5WSG|rcsb pdb:5Y88|rcsb pdb:5YLZ|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q|dip:DIP-1180N|mint:P25337	refseq:NP_015508.1|sgd:S000006386|dip:DIP-1634N|mint:P54999|ensemblfungi:YPR182W(gene)|ensemblfungi:YPR182W_mRNA(transcript)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005682"(U5 snRNP)|go:"GO:0005685"(U1 snRNP)|go:"GO:0005686"(U2 snRNP)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1990935"(splicing factor binding)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR016487(Small nuclear ribonucleoprotein SmF)|interpro:IPR034100|rcsb pdb:1N9R|rcsb pdb:1N9S|rcsb pdb:3JCM|rcsb pdb:5GAM|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GM6|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:5NRL|rcsb pdb:5WSG|rcsb pdb:5Y88|rcsb pdb:5YLZ|rcsb pdb:5ZWM|rcsb pdb:5ZWN|rcsb pdb:5ZWO|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:6G90|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q|rcsb pdb:6N7P|rcsb pdb:6N7R|rcsb pdb:6N7X|rcsb pdb:7B9V	-	crc64:70A8B15F8DA6F85D	crc64:1640D3237597B2D8	figure legend:Fig 1, Extended Data Fig 2,3, Extended Data Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/12/25	2020/12/25	rogid:DImrf7jgUrSuQtfiOvBeJr5Cl/w559292	rogid:iyBbVNf2fgOIqhnOg9Etn3P2r3Q559292	rigid:CS2BueyjIHJR/Bs/JncMFW0WTkg	false	-	-	1	1	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P25337	uniprotkb:P40204	intact:EBI-547|ensemblfungi:YCR063W|uniprotkb:D6VR67	intact:EBI-637|uniprotkb:D6VTL2|ensemblfungi:YFL017W-A	psi-mi:bud31_yeast(display_long)|uniprotkb:BUD31(gene name)|psi-mi:BUD31(display_short)|uniprotkb:Bud site selection protein 31(gene name synonym)|uniprotkb:CWC14(gene name synonym)|uniprotkb:Complexed with CEF1 protein 14(gene name synonym)|uniprotkb:YCR63W(orf name)|uniprotkb:YCR903(orf name)|uniprotkb:YCR063W(locus name)	psi-mi:ruxg_yeast(display_long)|uniprotkb:SNP2(gene name synonym)|uniprotkb:YFL017Bw(orf name)|uniprotkb:YFL017W-A(locus name)|uniprotkb:SMX2(gene name)|psi-mi:SMX2(display_short)|uniprotkb:Sm protein G(gene name synonym)	psi-mi:"MI:0410"(3D electron microscopy)	Galej et al. (2016)	imex:IM-28615|pubmed:27459055	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26571742|wwpdb:5LJ3|emdb:EMD-4055|imex:IM-28615-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009990.1|sgd:S000000659|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005686"(U2 snRNP)|interpro:IPR001748(G10 protein)|interpro:IPR018230|rcsb pdb:2MY1|ensemblfungi:YCR063W(gene)|ensemblfungi:YCR063W_mRNA(transcript)|go:"GO:0000282"(cellular bud site selection)|rcsb pdb:5GM6|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:5WSG|rcsb pdb:5Y88|rcsb pdb:5YLZ|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q|dip:DIP-1180N|mint:P25337	refseq:NP_116636.1|sgd:S000002965|dip:DIP-6683N|mint:P40204|ensemblfungi:YFL017W-A(gene)|ensemblfungi:YFL017W-A_mRNA(transcript)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005682"(U5 snRNP)|go:"GO:0005685"(U1 snRNP)|go:"GO:0005686"(U2 snRNP)|go:"GO:0005687"(U4 snRNP)|go:"GO:0005689"(U12-type spliceosomal complex)|go:"GO:0034719"(SMN-Sm protein complex)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071004"(U2-type prespliceosome)|go:"GO:0071011"(precatalytic spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0097526"(spliceosomal tri-snRNP complex)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR034098|interpro:IPR044641|rcsb pdb:3JCM|rcsb pdb:5GAM|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GM6|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:5NRL|rcsb pdb:5WSG|rcsb pdb:5Y88|rcsb pdb:5YLZ|rcsb pdb:5ZWM|rcsb pdb:5ZWN|rcsb pdb:5ZWO|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:6G90|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q|rcsb pdb:6N7P|rcsb pdb:6N7R|rcsb pdb:6N7X|rcsb pdb:7B9V|rcsb pdb:7DCO	-	crc64:70A8B15F8DA6F85D	crc64:5C6208B8C5A9AB33	figure legend:Fig 1, Extended Data Fig 2,3, Extended Data Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/12/25	2020/12/25	rogid:DImrf7jgUrSuQtfiOvBeJr5Cl/w559292	rogid:Wh37rGoSJFpJ5o+CuNkBnpiu/5s559292	rigid:CS2BueyjIHJR/Bs/JncMFW0WTkg	false	-	-	1	1	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P25337	uniprotkb:P38241	intact:EBI-547|ensemblfungi:YCR063W|uniprotkb:D6VR67	intact:EBI-780|uniprotkb:P89497|uniprotkb:D6VQ64|ensemblfungi:YBR065C	psi-mi:bud31_yeast(display_long)|uniprotkb:BUD31(gene name)|psi-mi:BUD31(display_short)|uniprotkb:Bud site selection protein 31(gene name synonym)|uniprotkb:CWC14(gene name synonym)|uniprotkb:Complexed with CEF1 protein 14(gene name synonym)|uniprotkb:YCR63W(orf name)|uniprotkb:YCR903(orf name)|uniprotkb:YCR063W(locus name)	psi-mi:slt11_yeast(display_long)|uniprotkb:ECM2(gene name)|psi-mi:ECM2(display_short)|uniprotkb:SLT11(gene name synonym)|uniprotkb:YBR065C(locus name)|uniprotkb:YBR0614(orf name)|uniprotkb:Synthetic lethality with U2 protein 11(gene name synonym)|uniprotkb:Extracellular mutant protein 2(gene name synonym)	psi-mi:"MI:0410"(3D electron microscopy)	Galej et al. (2016)	imex:IM-28615|pubmed:27459055	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26571742|wwpdb:5LJ3|emdb:EMD-4055|imex:IM-28615-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009990.1|sgd:S000000659|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005686"(U2 snRNP)|interpro:IPR001748(G10 protein)|interpro:IPR018230|rcsb pdb:2MY1|ensemblfungi:YCR063W(gene)|ensemblfungi:YCR063W_mRNA(transcript)|go:"GO:0000282"(cellular bud site selection)|rcsb pdb:5GM6|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:5WSG|rcsb pdb:5Y88|rcsb pdb:5YLZ|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q|dip:DIP-1180N|mint:P25337	sgd:S000000269|refseq:NP_009621.3|dip:DIP-5359N|mint:P38241|ensemblfungi:YBR065C(gene)|ensemblfungi:YBR065C_mRNA(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000974"(Prp19 complex)|go:"GO:0005634"(nucleus)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0071006"(U2-type catalytic step 1 spliceosome)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|interpro:IPR034356|interpro:IPR039171|rcsb pdb:5GM6|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:5WSG|rcsb pdb:5Y88|rcsb pdb:5YLZ|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q	-	crc64:70A8B15F8DA6F85D	crc64:BF21E687817A42B4	figure legend:Fig 1, Extended Data Fig 2,3, Extended Data Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/12/25	2020/12/25	rogid:DImrf7jgUrSuQtfiOvBeJr5Cl/w559292	rogid:ioGlVp9msutMpWXME0tICQn8GDQ559292	rigid:CS2BueyjIHJR/Bs/JncMFW0WTkg	false	-	-	1	1	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P25337	uniprotkb:Q02775	intact:EBI-547|ensemblfungi:YCR063W|uniprotkb:D6VR67	intact:EBI-17379|uniprotkb:P89902|uniprotkb:Q6Q5U3|uniprotkb:D6VS75|ensemblfungi:YDR088C	psi-mi:bud31_yeast(display_long)|uniprotkb:BUD31(gene name)|psi-mi:BUD31(display_short)|uniprotkb:Bud site selection protein 31(gene name synonym)|uniprotkb:CWC14(gene name synonym)|uniprotkb:Complexed with CEF1 protein 14(gene name synonym)|uniprotkb:YCR63W(orf name)|uniprotkb:YCR903(orf name)|uniprotkb:YCR063W(locus name)	psi-mi:slu7_yeast(display_long)|uniprotkb:SLU7(gene name)|psi-mi:SLU7(display_short)|uniprotkb:YDR088C(locus name)|uniprotkb:D4483(orf name)|uniprotkb:SLT17(gene name synonym)|uniprotkb:Synthetic lethal with U5 snRNA protein 7(gene name synonym)|uniprotkb:Synthetic lethal with U2 snRNA protein 17(gene name synonym)	psi-mi:"MI:0410"(3D electron microscopy)	Galej et al. (2016)	imex:IM-28615|pubmed:27459055	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26571742|wwpdb:5LJ3|emdb:EMD-4055|imex:IM-28615-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009990.1|sgd:S000000659|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005686"(U2 snRNP)|interpro:IPR001748(G10 protein)|interpro:IPR018230|rcsb pdb:2MY1|ensemblfungi:YCR063W(gene)|ensemblfungi:YCR063W_mRNA(transcript)|go:"GO:0000282"(cellular bud site selection)|rcsb pdb:5GM6|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:5WSG|rcsb pdb:5Y88|rcsb pdb:5YLZ|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q|dip:DIP-1180N|mint:P25337	refseq:NP_010373.3|sgd:S000002495|ensemblfungi:YDR088C(gene)|ensemblfungi:YDR088C_mRNA(transcript)|go:"GO:0000350"(generation of catalytic spliceosome for second transesterification step)|go:"GO:0000386"(second spliceosomal transesterification activity)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0030628"(pre-mRNA 3'-splice site binding)|go:"GO:0071021"(U2-type post-spliceosomal complex)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR021715|interpro:IPR036875|interpro:IPR039974|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:5YLZ|mint:Q02775|dip:DIP-220N	-	crc64:70A8B15F8DA6F85D	crc64:6405458FC367A7D3	figure legend:Fig 1, Extended Data Fig 2,3, Extended Data Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/12/25	2020/12/25	rogid:DImrf7jgUrSuQtfiOvBeJr5Cl/w559292	rogid:an3IJpPrRlLX0cALtTMg4C2JxUI559292	rigid:CS2BueyjIHJR/Bs/JncMFW0WTkg	false	-	calmodulin binding peptide plus protein a tag:?-?	1	1	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P25337	uniprotkb:Q02260	intact:EBI-547|ensemblfungi:YCR063W|uniprotkb:D6VR67	intact:EBI-585|uniprotkb:D6VUK6|ensemblfungi:YGR074W	psi-mi:bud31_yeast(display_long)|uniprotkb:BUD31(gene name)|psi-mi:BUD31(display_short)|uniprotkb:Bud site selection protein 31(gene name synonym)|uniprotkb:CWC14(gene name synonym)|uniprotkb:Complexed with CEF1 protein 14(gene name synonym)|uniprotkb:YCR63W(orf name)|uniprotkb:YCR903(orf name)|uniprotkb:YCR063W(locus name)	psi-mi:smd1_yeast(display_long)|uniprotkb:YGR074W(locus name)|uniprotkb:SMD1(gene name)|psi-mi:SMD1(display_short)|uniprotkb:snRNP core protein D1(gene name synonym)	psi-mi:"MI:0410"(3D electron microscopy)	Galej et al. (2016)	imex:IM-28615|pubmed:27459055	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26571742|wwpdb:5LJ3|emdb:EMD-4055|imex:IM-28615-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009990.1|sgd:S000000659|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005686"(U2 snRNP)|interpro:IPR001748(G10 protein)|interpro:IPR018230|rcsb pdb:2MY1|ensemblfungi:YCR063W(gene)|ensemblfungi:YCR063W_mRNA(transcript)|go:"GO:0000282"(cellular bud site selection)|rcsb pdb:5GM6|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:5WSG|rcsb pdb:5Y88|rcsb pdb:5YLZ|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q|dip:DIP-1180N|mint:P25337	sgd:S000003306|refseq:NP_011588.3|dip:DIP-227N|mint:Q02260|ensemblfungi:YGR074W(gene)|ensemblfungi:YGR074W_mRNA(transcript)|go:"GO:0000243"(commitment complex)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005682"(U5 snRNP)|go:"GO:0005685"(U1 snRNP)|go:"GO:0005686"(U2 snRNP)|go:"GO:0005689"(U12-type spliceosomal complex)|go:"GO:0005829"(cytosol)|go:"GO:0030532"(small nuclear ribonucleoprotein complex)|go:"GO:0034715"(pICln-Sm protein complex)|go:"GO:0005687"(U4 snRNP)|go:"GO:0034719"(SMN-Sm protein complex)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071004"(U2-type prespliceosome)|go:"GO:0071011"(precatalytic spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0097526"(spliceosomal tri-snRNP complex)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR027141|rcsb pdb:3JCM|rcsb pdb:5GAM|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GM6|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:5NRL|rcsb pdb:5WSG|rcsb pdb:5Y88|rcsb pdb:5YLZ|rcsb pdb:5ZWM|rcsb pdb:5ZWN|rcsb pdb:5ZWO|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:6G90|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q|rcsb pdb:6N7P|rcsb pdb:6N7R|rcsb pdb:6N7X|rcsb pdb:7B9V	-	crc64:70A8B15F8DA6F85D	crc64:9929F21EB9218447	figure legend:Fig 1, Extended Data Fig 2,3, Extended Data Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/12/25	2020/12/25	rogid:DImrf7jgUrSuQtfiOvBeJr5Cl/w559292	rogid:SvOKDbY05xgJXKZ8uS+keXsC41I559292	rigid:CS2BueyjIHJR/Bs/JncMFW0WTkg	false	-	-	1	1	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P25337	uniprotkb:Q06217	intact:EBI-547|ensemblfungi:YCR063W|uniprotkb:D6VR67	intact:EBI-235|uniprotkb:D6VYS2|ensemblfungi:YLR275W	psi-mi:bud31_yeast(display_long)|uniprotkb:BUD31(gene name)|psi-mi:BUD31(display_short)|uniprotkb:Bud site selection protein 31(gene name synonym)|uniprotkb:CWC14(gene name synonym)|uniprotkb:Complexed with CEF1 protein 14(gene name synonym)|uniprotkb:YCR63W(orf name)|uniprotkb:YCR903(orf name)|uniprotkb:YCR063W(locus name)	psi-mi:smd2_yeast(display_long)|uniprotkb:SMD2(gene name)|psi-mi:SMD2(display_short)|uniprotkb:YLR275W(locus name)|uniprotkb:L9328.5(orf name)|uniprotkb:snRNP core protein D2(gene name synonym)	psi-mi:"MI:0410"(3D electron microscopy)	Galej et al. (2016)	imex:IM-28615|pubmed:27459055	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26571742|wwpdb:5LJ3|emdb:EMD-4055|imex:IM-28615-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009990.1|sgd:S000000659|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005686"(U2 snRNP)|interpro:IPR001748(G10 protein)|interpro:IPR018230|rcsb pdb:2MY1|ensemblfungi:YCR063W(gene)|ensemblfungi:YCR063W_mRNA(transcript)|go:"GO:0000282"(cellular bud site selection)|rcsb pdb:5GM6|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:5WSG|rcsb pdb:5Y88|rcsb pdb:5YLZ|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q|dip:DIP-1180N|mint:P25337	sgd:S000004265|refseq:NP_013377.1|mint:Q06217|dip:DIP-1421N|ensemblfungi:YLR275W(gene)|ensemblfungi:YLR275W_mRNA(transcript)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0003723"(RNA binding)|go:"GO:0005682"(U5 snRNP)|go:"GO:0005685"(U1 snRNP)|go:"GO:0005686"(U2 snRNP)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071004"(U2-type prespliceosome)|go:"GO:0071011"(precatalytic spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR027248|rcsb pdb:3JCM|rcsb pdb:5GAM|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GM6|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:5NRL|rcsb pdb:5WSG|rcsb pdb:5Y88|rcsb pdb:5YLZ|rcsb pdb:5ZWM|rcsb pdb:5ZWN|rcsb pdb:5ZWO|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:6G90|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q|rcsb pdb:6N7P|rcsb pdb:6N7R|rcsb pdb:6N7X|rcsb pdb:7B9V	-	crc64:70A8B15F8DA6F85D	crc64:7287070B10E090C0	figure legend:Fig 1, Extended Data Fig 2,3, Extended Data Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/12/25	2020/12/25	rogid:DImrf7jgUrSuQtfiOvBeJr5Cl/w559292	rogid:rglZ3AQuJfa1rFYIeZLqiYj+L4U559292	rigid:CS2BueyjIHJR/Bs/JncMFW0WTkg	false	-	-	1	1	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P25337	uniprotkb:P43321	intact:EBI-547|ensemblfungi:YCR063W|uniprotkb:D6VR67	intact:EBI-529|ensemblfungi:YLR147C|uniprotkb:D6VYE2|uniprotkb:E9P8W3	psi-mi:bud31_yeast(display_long)|uniprotkb:BUD31(gene name)|psi-mi:BUD31(display_short)|uniprotkb:Bud site selection protein 31(gene name synonym)|uniprotkb:CWC14(gene name synonym)|uniprotkb:Complexed with CEF1 protein 14(gene name synonym)|uniprotkb:YCR63W(orf name)|uniprotkb:YCR903(orf name)|uniprotkb:YCR063W(locus name)	psi-mi:smd3_yeast(display_long)|uniprotkb:SMD3(gene name)|psi-mi:SMD3(display_short)|uniprotkb:YLR147C(locus name)|uniprotkb:L9634.6(orf name)|uniprotkb:snRNP core protein D3(gene name synonym)	psi-mi:"MI:0410"(3D electron microscopy)	Galej et al. (2016)	imex:IM-28615|pubmed:27459055	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26571742|wwpdb:5LJ3|emdb:EMD-4055|imex:IM-28615-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009990.1|sgd:S000000659|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005686"(U2 snRNP)|interpro:IPR001748(G10 protein)|interpro:IPR018230|rcsb pdb:2MY1|ensemblfungi:YCR063W(gene)|ensemblfungi:YCR063W_mRNA(transcript)|go:"GO:0000282"(cellular bud site selection)|rcsb pdb:5GM6|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:5WSG|rcsb pdb:5Y88|rcsb pdb:5YLZ|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q|dip:DIP-1180N|mint:P25337	refseq:NP_013248.1|sgd:S000004137|rcsb pdb:5YLZ|rcsb pdb:5ZWM|rcsb pdb:5ZWN|rcsb pdb:5ZWO|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:6G90|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q|rcsb pdb:6N7P|rcsb pdb:6N7R|rcsb pdb:6N7X|rcsb pdb:7B9V|ensemblfungi:YLR147C(gene)|ensemblfungi:YLR147C_mRNA(transcript)|go:"GO:0000243"(commitment complex)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005682"(U5 snRNP)|go:"GO:0005685"(U1 snRNP)|go:"GO:0005686"(U2 snRNP)|go:"GO:0005687"(U4 snRNP)|go:"GO:0005689"(U12-type spliceosomal complex)|go:"GO:0034715"(pICln-Sm protein complex)|go:"GO:0034719"(SMN-Sm protein complex)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071004"(U2-type prespliceosome)|go:"GO:0071011"(precatalytic spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0097526"(spliceosomal tri-snRNP complex)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR027141|interpro:IPR034099|rcsb pdb:3JCM|rcsb pdb:5GAM|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GM6|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:5NRL|rcsb pdb:5WSG|rcsb pdb:5Y88|dip:DIP-715N|mint:P43321	-	crc64:70A8B15F8DA6F85D	crc64:BB02A56C5AD70CF2	figure legend:Fig 1, Extended Data Fig 2,3, Extended Data Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/12/25	2020/12/25	rogid:DImrf7jgUrSuQtfiOvBeJr5Cl/w559292	rogid:ueJ4D76t8ilvz/p9qMzIGiCzqWk559292	rigid:CS2BueyjIHJR/Bs/JncMFW0WTkg	false	-	-	1	1	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P25337	uniprotkb:P36048	intact:EBI-547|ensemblfungi:YCR063W|uniprotkb:D6VR67	intact:EBI-243|uniprotkb:D6VX27|ensemblfungi:YKL173W	psi-mi:bud31_yeast(display_long)|uniprotkb:BUD31(gene name)|psi-mi:BUD31(display_short)|uniprotkb:Bud site selection protein 31(gene name synonym)|uniprotkb:CWC14(gene name synonym)|uniprotkb:Complexed with CEF1 protein 14(gene name synonym)|uniprotkb:YCR63W(orf name)|uniprotkb:YCR903(orf name)|uniprotkb:YCR063W(locus name)	psi-mi:sn114_yeast(display_long)|uniprotkb:GIN10(gene name synonym)|uniprotkb:YKL173W(locus name)|uniprotkb:YKL637(orf name)|uniprotkb:SNU114(gene name)|psi-mi:SNU114(display_short)|uniprotkb:Growth inhibitory protein 10(gene name synonym)|uniprotkb:114 kDa U5 small nuclear ribonucleoprotein component(gene name synonym)	psi-mi:"MI:0410"(3D electron microscopy)	Galej et al. (2016)	imex:IM-28615|pubmed:27459055	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26571742|wwpdb:5LJ3|emdb:EMD-4055|imex:IM-28615-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009990.1|sgd:S000000659|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005686"(U2 snRNP)|interpro:IPR001748(G10 protein)|interpro:IPR018230|rcsb pdb:2MY1|ensemblfungi:YCR063W(gene)|ensemblfungi:YCR063W_mRNA(transcript)|go:"GO:0000282"(cellular bud site selection)|rcsb pdb:5GM6|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:5WSG|rcsb pdb:5Y88|rcsb pdb:5YLZ|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q|dip:DIP-1180N|mint:P25337	refseq:NP_012748.1|sgd:S000001656|mint:P36048|dip:DIP-759N|ensemblfungi:YKL173W(gene)|ensemblfungi:YKL173W_mRNA(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000349"(generation of catalytic spliceosome for first transesterification step)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005682"(U5 snRNP)|go:"GO:0030623"(U5 snRNA binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000640(Translation elongation factor EFG/EF2, C-terminal)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR005517(Translation elongation factor EFG/EF2, domain IV)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR020568|interpro:IPR027417|interpro:IPR031950|interpro:IPR035647|interpro:IPR035655|interpro:IPR044121|rcsb pdb:3JCM|rcsb pdb:5GAM|rcsb pdb:5GAN|rcsb pdb:5GM6|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:5NRL|rcsb pdb:5WSG|rcsb pdb:5Y88|rcsb pdb:5YLZ|rcsb pdb:5ZWM|rcsb pdb:5ZWO|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q|rcsb pdb:6TEO	-	crc64:70A8B15F8DA6F85D	crc64:5CE30CEFF154D013	figure legend:Fig 1, Extended Data Fig 2,3, Extended Data Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/12/25	2020/12/25	rogid:DImrf7jgUrSuQtfiOvBeJr5Cl/w559292	rogid:eHDUPadk87+Qb525xpL1tMWb3S4559292	rigid:CS2BueyjIHJR/Bs/JncMFW0WTkg	false	-	-	1	1	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P25337	uniprotkb:Q04048	intact:EBI-547|ensemblfungi:YCR063W|uniprotkb:D6VR67	intact:EBI-540|uniprotkb:D6VT47|ensemblfungi:YDR416W	psi-mi:bud31_yeast(display_long)|uniprotkb:BUD31(gene name)|psi-mi:BUD31(display_short)|uniprotkb:Bud site selection protein 31(gene name synonym)|uniprotkb:CWC14(gene name synonym)|uniprotkb:Complexed with CEF1 protein 14(gene name synonym)|uniprotkb:YCR63W(orf name)|uniprotkb:YCR903(orf name)|uniprotkb:YCR063W(locus name)	psi-mi:syf1_yeast(display_long)|uniprotkb:SYF1(gene name)|psi-mi:SYF1(display_short)|uniprotkb:NTC90(gene name synonym)|uniprotkb:Synthetic lethal with CDC40 protein 1(gene name synonym)|uniprotkb:PRP19-associated complex protein 90(gene name synonym)|uniprotkb:YDR416W(locus name)	psi-mi:"MI:0410"(3D electron microscopy)	Galej et al. (2016)	imex:IM-28615|pubmed:27459055	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26571742|wwpdb:5LJ3|emdb:EMD-4055|imex:IM-28615-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009990.1|sgd:S000000659|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005686"(U2 snRNP)|interpro:IPR001748(G10 protein)|interpro:IPR018230|rcsb pdb:2MY1|ensemblfungi:YCR063W(gene)|ensemblfungi:YCR063W_mRNA(transcript)|go:"GO:0000282"(cellular bud site selection)|rcsb pdb:5GM6|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:5WSG|rcsb pdb:5Y88|rcsb pdb:5YLZ|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q|dip:DIP-1180N|mint:P25337	refseq:NP_010704.1|sgd:S000002824|rcsb pdb:5YLZ|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q|reactome:R-SCE-6781823|reactome:R-SCE-6782135|reactome:R-SCE-6782210|rcsb pdb:5Y88|ensemblfungi:YDR416W(gene)|ensemblfungi:YDR416W_mRNA(transcript)|go:"GO:0000349"(generation of catalytic spliceosome for first transesterification step)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000974"(Prp19 complex)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0071004"(U2-type prespliceosome)|go:"GO:0071006"(U2-type catalytic step 1 spliceosome)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071008"(U2-type post-mRNA release spliceosomal complex)|go:"GO:0071014"(post-mRNA release spliceosomal complex)|interpro:IPR003107(RNA-processing protein, HAT helix)|interpro:IPR011990(Tetratricopeptide-like helical)|rcsb pdb:5GM6|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:5WSG|dip:DIP-1681N|mint:Q04048	-	crc64:70A8B15F8DA6F85D	crc64:ED4368A624A40E7C	figure legend:Fig 1, Extended Data Fig 2,3, Extended Data Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/12/25	2020/12/25	rogid:DImrf7jgUrSuQtfiOvBeJr5Cl/w559292	rogid:+1TwiqsQv1IcWxuoIWcJGtTCUFU559292	rigid:CS2BueyjIHJR/Bs/JncMFW0WTkg	false	-	-	1	1	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P25337	uniprotkb:P28320	intact:EBI-547|ensemblfungi:YCR063W|uniprotkb:D6VR67	intact:EBI-26795|uniprotkb:D6VXJ3|ensemblfungi:YKL095W	psi-mi:bud31_yeast(display_long)|uniprotkb:BUD31(gene name)|psi-mi:BUD31(display_short)|uniprotkb:Bud site selection protein 31(gene name synonym)|uniprotkb:CWC14(gene name synonym)|uniprotkb:Complexed with CEF1 protein 14(gene name synonym)|uniprotkb:YCR63W(orf name)|uniprotkb:YCR903(orf name)|uniprotkb:YCR063W(locus name)	psi-mi:yju2_yeast(display_long)|uniprotkb:YKL095W(locus name)|uniprotkb:YKL442(orf name)|uniprotkb:YJU2(gene name)|psi-mi:YJU2(display_short)|uniprotkb:CWC16(gene name synonym)	psi-mi:"MI:0410"(3D electron microscopy)	Galej et al. (2016)	imex:IM-28615|pubmed:27459055	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26571742|wwpdb:5LJ3|emdb:EMD-4055|imex:IM-28615-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009990.1|sgd:S000000659|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005686"(U2 snRNP)|interpro:IPR001748(G10 protein)|interpro:IPR018230|rcsb pdb:2MY1|ensemblfungi:YCR063W(gene)|ensemblfungi:YCR063W_mRNA(transcript)|go:"GO:0000282"(cellular bud site selection)|rcsb pdb:5GM6|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:5WSG|rcsb pdb:5Y88|rcsb pdb:5YLZ|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q|dip:DIP-1180N|mint:P25337	refseq:NP_012828.1|sgd:S000001578|mint:P28320|dip:DIP-1915N|ensemblfungi:YKL095W(gene)|ensemblfungi:YKL095W_mRNA(transcript)|go:"GO:0000349"(generation of catalytic spliceosome for first transesterification step)|go:"GO:0000350"(generation of catalytic spliceosome for second transesterification step)|go:"GO:0005634"(nucleus)|go:"GO:0008380"(RNA splicing)|go:"GO:0030620"(U2 snRNA binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0071006"(U2-type catalytic step 1 spliceosome)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|interpro:IPR007590(Protein of unknown function DUF572)|interpro:IPR043701|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5Y88|rcsb pdb:6EXN|rcsb pdb:6J6Q	-	crc64:70A8B15F8DA6F85D	crc64:B57F3A173A2113FD	figure legend:Fig 1, Extended Data Fig 2,3, Extended Data Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/12/25	2020/12/25	rogid:DImrf7jgUrSuQtfiOvBeJr5Cl/w559292	rogid:RB1yjFkujiRVEYwnEtk3x0Beo88559292	rigid:CS2BueyjIHJR/Bs/JncMFW0WTkg	false	-	-	1	1	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P32639	uniprotkb:P25337	intact:EBI-861|uniprotkb:D3DM80|ensemblfungi:YER172C	intact:EBI-547|ensemblfungi:YCR063W|uniprotkb:D6VR67	psi-mi:brr2_yeast(display_long)|uniprotkb:BRR2(gene name)|psi-mi:BRR2(display_short)|uniprotkb:RSS1(gene name synonym)|uniprotkb:SNU246(gene name synonym)|uniprotkb:YER172C(locus name)|uniprotkb:SYGP-ORF66(orf name)|uniprotkb:Protein Snu246(gene name synonym)	psi-mi:bud31_yeast(display_long)|uniprotkb:BUD31(gene name)|psi-mi:BUD31(display_short)|uniprotkb:Bud site selection protein 31(gene name synonym)|uniprotkb:CWC14(gene name synonym)|uniprotkb:Complexed with CEF1 protein 14(gene name synonym)|uniprotkb:YCR63W(orf name)|uniprotkb:YCR903(orf name)|uniprotkb:YCR063W(locus name)	psi-mi:"MI:0071"(molecular sieving)	Galej et al. (2016)	imex:IM-28615|pubmed:27459055	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26571789|imex:IM-28615-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011099.1|sgd:S000000974|dip:DIP-850N|mint:P32639|ensemblfungi:YER172C(gene)|ensemblfungi:YER172C_mRNA(transcript)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|rcsb pdb:3HIB|rcsb pdb:3IM1|rcsb pdb:3IM2|rcsb pdb:3JCM|rcsb pdb:4BGD|rcsb pdb:5DCA|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GAP|rcsb pdb:5GM6|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5M52|rcsb pdb:5M5P|rcsb pdb:5NRL|rcsb pdb:5ZWM|rcsb pdb:5ZWO|rcsb pdb:7B9V	refseq:NP_009990.1|sgd:S000000659|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005686"(U2 snRNP)|interpro:IPR001748(G10 protein)|interpro:IPR018230|rcsb pdb:2MY1|ensemblfungi:YCR063W(gene)|ensemblfungi:YCR063W_mRNA(transcript)|go:"GO:0000282"(cellular bud site selection)|rcsb pdb:5GM6|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:5WSG|rcsb pdb:5Y88|rcsb pdb:5YLZ|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q|dip:DIP-1180N|mint:P25337	-	crc64:DFAF7E3B7168D944	crc64:70A8B15F8DA6F85D	figure legend:Extended Data Fig 1a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/25	2021/01/05	rogid:2bNoVkou3QatkNCtPIiSdvPdgEo559292	rogid:DImrf7jgUrSuQtfiOvBeJr5Cl/w559292	rigid:icMPk+gSwfNCxH1Agk9cl1QN5wQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P32639	uniprotkb:Q03654	intact:EBI-861|uniprotkb:D3DM80|ensemblfungi:YER172C	intact:EBI-476|uniprotkb:Q6B1D8|ensemblfungi:YMR213W|uniprotkb:D6W038	psi-mi:brr2_yeast(display_long)|uniprotkb:BRR2(gene name)|psi-mi:BRR2(display_short)|uniprotkb:RSS1(gene name synonym)|uniprotkb:SNU246(gene name synonym)|uniprotkb:YER172C(locus name)|uniprotkb:SYGP-ORF66(orf name)|uniprotkb:Protein Snu246(gene name synonym)	psi-mi:cef1_yeast(display_long)|uniprotkb:CEF1(gene name)|psi-mi:CEF1(display_short)|uniprotkb:YMR213W(locus name)|uniprotkb:YM8261.07(orf name)|uniprotkb:NTC85(gene name synonym)|uniprotkb:PRP nineteen-associated complex protein 85(gene name synonym)|uniprotkb:PRP19-associated complex protein 85(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Galej et al. (2016)	imex:IM-28615|pubmed:27459055	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26571789|imex:IM-28615-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011099.1|sgd:S000000974|dip:DIP-850N|mint:P32639|ensemblfungi:YER172C(gene)|ensemblfungi:YER172C_mRNA(transcript)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|rcsb pdb:3HIB|rcsb pdb:3IM1|rcsb pdb:3IM2|rcsb pdb:3JCM|rcsb pdb:4BGD|rcsb pdb:5DCA|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GAP|rcsb pdb:5GM6|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5M52|rcsb pdb:5M5P|rcsb pdb:5NRL|rcsb pdb:5ZWM|rcsb pdb:5ZWO|rcsb pdb:7B9V	refseq:NP_013940.1|sgd:S000004826|ensemblfungi:YMR213W(gene)|ensemblfungi:YMR213W_mRNA(transcript)|go:"GO:0000350"(generation of catalytic spliceosome for second transesterification step)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000974"(Prp19 complex)|go:"GO:0003677"(DNA binding)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0071006"(U2-type catalytic step 1 spliceosome)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017930|interpro:IPR021786|rcsb pdb:5GM6|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:5WSG|rcsb pdb:5Y88|rcsb pdb:5YLZ|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q|rcsb pdb:7DCO|dip:DIP-1113N|mint:Q03654	-	crc64:DFAF7E3B7168D944	crc64:A4C417A8B330EA9C	figure legend:Extended Data Fig 1a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/25	2021/01/05	rogid:2bNoVkou3QatkNCtPIiSdvPdgEo559292	rogid:AsbV7RtNk+8mCzLk2wZYqbULOFg559292	rigid:icMPk+gSwfNCxH1Agk9cl1QN5wQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P32639	uniprotkb:Q12309	intact:EBI-861|uniprotkb:D3DM80|ensemblfungi:YER172C	intact:EBI-484|uniprotkb:D6VYB5|ensemblfungi:YLR117C	psi-mi:brr2_yeast(display_long)|uniprotkb:BRR2(gene name)|psi-mi:BRR2(display_short)|uniprotkb:RSS1(gene name synonym)|uniprotkb:SNU246(gene name synonym)|uniprotkb:YER172C(locus name)|uniprotkb:SYGP-ORF66(orf name)|uniprotkb:Protein Snu246(gene name synonym)	psi-mi:clf1_yeast(display_long)|uniprotkb:CLF1(gene name)|psi-mi:CLF1(display_short)|uniprotkb:NTC77(gene name synonym)|uniprotkb:YLR117C(locus name)|uniprotkb:SYF3(gene name synonym)|uniprotkb:L2952(orf name)|uniprotkb:Crooked neck-like factor 1(gene name synonym)|uniprotkb:PRP19-associated complex protein 77(gene name synonym)|uniprotkb:Synthetic lethal with CDC40 protein 3(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Galej et al. (2016)	imex:IM-28615|pubmed:27459055	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26571789|imex:IM-28615-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011099.1|sgd:S000000974|dip:DIP-850N|mint:P32639|ensemblfungi:YER172C(gene)|ensemblfungi:YER172C_mRNA(transcript)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|rcsb pdb:3HIB|rcsb pdb:3IM1|rcsb pdb:3IM2|rcsb pdb:3JCM|rcsb pdb:4BGD|rcsb pdb:5DCA|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GAP|rcsb pdb:5GM6|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5M52|rcsb pdb:5M5P|rcsb pdb:5NRL|rcsb pdb:5ZWM|rcsb pdb:5ZWO|rcsb pdb:7B9V	refseq:NP_013218.1|sgd:S000004107|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q|rcsb pdb:5GM6|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:5WSG|rcsb pdb:5Y88|rcsb pdb:5YLZ|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:6J6G|ensemblfungi:YLR117C(gene)|ensemblfungi:YLR117C_mRNA(transcript)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000354"(cis assembly of pre-catalytic spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000785"(chromatin)|go:"GO:0000974"(Prp19 complex)|go:"GO:0003682"(chromatin binding)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0071004"(U2-type prespliceosome)|go:"GO:0071006"(U2-type catalytic step 1 spliceosome)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071008"(U2-type post-mRNA release spliceosomal complex)|go:"GO:0071014"(post-mRNA release spliceosomal complex)|interpro:IPR003107(RNA-processing protein, HAT helix)|interpro:IPR011990(Tetratricopeptide-like helical)|dip:DIP-1685N|mint:Q12309	-	crc64:DFAF7E3B7168D944	crc64:AE7D5EC5B3979E00	figure legend:Extended Data Fig 1a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/25	2021/01/05	rogid:2bNoVkou3QatkNCtPIiSdvPdgEo559292	rogid:VbNHO9YGUushIXHTgscFu4xCzC4559292	rigid:icMPk+gSwfNCxH1Agk9cl1QN5wQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P32639	uniprotkb:Q03772	intact:EBI-861|uniprotkb:D3DM80|ensemblfungi:YER172C	intact:EBI-36780|uniprotkb:D6VSE3|ensemblfungi:YDR163W	psi-mi:brr2_yeast(display_long)|uniprotkb:BRR2(gene name)|psi-mi:BRR2(display_short)|uniprotkb:RSS1(gene name synonym)|uniprotkb:SNU246(gene name synonym)|uniprotkb:YER172C(locus name)|uniprotkb:SYGP-ORF66(orf name)|uniprotkb:Protein Snu246(gene name synonym)	psi-mi:cwc15_yeast(display_long)|uniprotkb:CWC15(gene name)|psi-mi:CWC15(display_short)|uniprotkb:Complexed with CEF1 protein 15(gene name synonym)|uniprotkb:YDR163W(locus name)|uniprotkb:YD8358.17(orf name)	psi-mi:"MI:0071"(molecular sieving)	Galej et al. (2016)	imex:IM-28615|pubmed:27459055	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26571789|imex:IM-28615-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011099.1|sgd:S000000974|dip:DIP-850N|mint:P32639|ensemblfungi:YER172C(gene)|ensemblfungi:YER172C_mRNA(transcript)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|rcsb pdb:3HIB|rcsb pdb:3IM1|rcsb pdb:3IM2|rcsb pdb:3JCM|rcsb pdb:4BGD|rcsb pdb:5DCA|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GAP|rcsb pdb:5GM6|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5M52|rcsb pdb:5M5P|rcsb pdb:5NRL|rcsb pdb:5ZWM|rcsb pdb:5ZWO|rcsb pdb:7B9V	sgd:S000002570|interpro:IPR006973(Cwf15/Cwc15 cell cycle control protein)|refseq:NP_010447.3|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:5WSG|rcsb pdb:5GM6|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:5Y88|rcsb pdb:5YLZ|ensemblfungi:YDR163W(gene)|ensemblfungi:YDR163W_mRNA(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005684"(U2-type spliceosomal complex)|go:"GO:0045292"(mRNA cis splicing, via spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|rcsb pdb:7DCO	-	crc64:DFAF7E3B7168D944	-	figure legend:Extended Data Fig 1a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/25	2021/01/05	rogid:2bNoVkou3QatkNCtPIiSdvPdgEo559292	rogid:raWAr5hiD2qEEeUG/lcMNpo1lhM559292	rigid:icMPk+gSwfNCxH1Agk9cl1QN5wQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P32639	uniprotkb:Q03375	intact:EBI-861|uniprotkb:D3DM80|ensemblfungi:YER172C	intact:EBI-30409|uniprotkb:D6VTA5|ensemblfungi:YDR482C	psi-mi:brr2_yeast(display_long)|uniprotkb:BRR2(gene name)|psi-mi:BRR2(display_short)|uniprotkb:RSS1(gene name synonym)|uniprotkb:SNU246(gene name synonym)|uniprotkb:YER172C(locus name)|uniprotkb:SYGP-ORF66(orf name)|uniprotkb:Protein Snu246(gene name synonym)	psi-mi:cwc21_yeast(display_long)|uniprotkb:YDR482C(locus name)|uniprotkb:Complexed with CEF1 protein 21(gene name synonym)|uniprotkb:CWC21(gene name)|psi-mi:CWC21(display_short)	psi-mi:"MI:0071"(molecular sieving)	Galej et al. (2016)	imex:IM-28615|pubmed:27459055	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26571789|imex:IM-28615-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011099.1|sgd:S000000974|dip:DIP-850N|mint:P32639|ensemblfungi:YER172C(gene)|ensemblfungi:YER172C_mRNA(transcript)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|rcsb pdb:3HIB|rcsb pdb:3IM1|rcsb pdb:3IM2|rcsb pdb:3JCM|rcsb pdb:4BGD|rcsb pdb:5DCA|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GAP|rcsb pdb:5GM6|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5M52|rcsb pdb:5M5P|rcsb pdb:5NRL|rcsb pdb:5ZWM|rcsb pdb:5ZWO|rcsb pdb:7B9V	sgd:S000002890|refseq:NP_010770.3|dip:DIP-1847N|mint:Q03375|ensemblfungi:YDR482C(gene)|ensemblfungi:YDR482C_mRNA(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005684"(U2-type spliceosomal complex)|go:"GO:0005737"(cytoplasm)|interpro:IPR013170(mRNA splicing factor, Cwf21)|rcsb pdb:5GM6|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:5WSG|rcsb pdb:5YLZ|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q	-	crc64:DFAF7E3B7168D944	crc64:9723E1C0A393508B	figure legend:Extended Data Fig 1a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/25	2021/01/05	rogid:2bNoVkou3QatkNCtPIiSdvPdgEo559292	rogid:dXmh6RsUTTtGZ8d1CnRgs1Ma+VI559292	rigid:icMPk+gSwfNCxH1Agk9cl1QN5wQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P32639	uniprotkb:P53854	intact:EBI-861|uniprotkb:D3DM80|ensemblfungi:YER172C	intact:EBI-29221|uniprotkb:D6W0U8|ensemblfungi:YNL245C	psi-mi:brr2_yeast(display_long)|uniprotkb:BRR2(gene name)|psi-mi:BRR2(display_short)|uniprotkb:RSS1(gene name synonym)|uniprotkb:SNU246(gene name synonym)|uniprotkb:YER172C(locus name)|uniprotkb:SYGP-ORF66(orf name)|uniprotkb:Protein Snu246(gene name synonym)	psi-mi:cwc25_yeast(display_long)|uniprotkb:Complexed with CEF1 protein 25(gene name synonym)|uniprotkb:YNL245C(locus name)|uniprotkb:N0901(orf name)|uniprotkb:CWC25(gene name)|psi-mi:CWC25(display_short)	psi-mi:"MI:0071"(molecular sieving)	Galej et al. (2016)	imex:IM-28615|pubmed:27459055	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26571789|imex:IM-28615-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011099.1|sgd:S000000974|dip:DIP-850N|mint:P32639|ensemblfungi:YER172C(gene)|ensemblfungi:YER172C_mRNA(transcript)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|rcsb pdb:3HIB|rcsb pdb:3IM1|rcsb pdb:3IM2|rcsb pdb:3JCM|rcsb pdb:4BGD|rcsb pdb:5DCA|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GAP|rcsb pdb:5GM6|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5M52|rcsb pdb:5M5P|rcsb pdb:5NRL|rcsb pdb:5ZWM|rcsb pdb:5ZWO|rcsb pdb:7B9V	refseq:NP_014154.1|sgd:S000005189|dip:DIP-2781N|ensemblfungi:YNL245C(gene)|ensemblfungi:YNL245C_mRNA(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005684"(U2-type spliceosomal complex)|interpro:IPR019339|interpro:IPR022209|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5	-	crc64:DFAF7E3B7168D944	-	figure legend:Extended Data Fig 1a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/25	2021/01/05	rogid:2bNoVkou3QatkNCtPIiSdvPdgEo559292	rogid:6bRgoCHPWEJzKP26V+7zR6CtCMY559292	rigid:icMPk+gSwfNCxH1Agk9cl1QN5wQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P32639	uniprotkb:Q12046	intact:EBI-861|uniprotkb:D3DM80|ensemblfungi:YER172C	intact:EBI-553|ensemblfungi:YDL209C|uniprotkb:D6VRE5	psi-mi:brr2_yeast(display_long)|uniprotkb:BRR2(gene name)|psi-mi:BRR2(display_short)|uniprotkb:RSS1(gene name synonym)|uniprotkb:SNU246(gene name synonym)|uniprotkb:YER172C(locus name)|uniprotkb:SYGP-ORF66(orf name)|uniprotkb:Protein Snu246(gene name synonym)	psi-mi:cwc2_yeast(display_long)|uniprotkb:CWC2(gene name)|psi-mi:CWC2(display_short)|uniprotkb:YDL209C(locus name)|uniprotkb:D1041(orf name)|uniprotkb:NTC40(gene name synonym)|uniprotkb:SLC3(gene name synonym)|uniprotkb:Complexed with CEF1 protein 2(gene name synonym)|uniprotkb:PRP19-associated complex protein 40(gene name synonym)|uniprotkb:Synthetic lethal with CLF1 protein 3(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Galej et al. (2016)	imex:IM-28615|pubmed:27459055	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26571789|imex:IM-28615-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011099.1|sgd:S000000974|dip:DIP-850N|mint:P32639|ensemblfungi:YER172C(gene)|ensemblfungi:YER172C_mRNA(transcript)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|rcsb pdb:3HIB|rcsb pdb:3IM1|rcsb pdb:3IM2|rcsb pdb:3JCM|rcsb pdb:4BGD|rcsb pdb:5DCA|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GAP|rcsb pdb:5GM6|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5M52|rcsb pdb:5M5P|rcsb pdb:5NRL|rcsb pdb:5ZWM|rcsb pdb:5ZWO|rcsb pdb:7B9V	interpro:IPR000571(Zinc finger, CCCH-type)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR032297|interpro:IPR034181|interpro:IPR035979|interpro:IPR039171|interpro:IPR039173|rcsb pdb:3TP2|rcsb pdb:3U1L|rcsb pdb:3U1M|rcsb pdb:5GM6|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:5WSG|rcsb pdb:5Y88|rcsb pdb:5YLZ|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|refseq:NP_010072.1|sgd:S000002368|ensemblfungi:YDL209C(gene)|ensemblfungi:YDL209C_mRNA(transcript)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000974"(Prp19 complex)|go:"GO:0007049"(cell cycle)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0045292"(mRNA cis splicing, via spliceosome)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0046872"(metal ion binding)|go:"GO:0071006"(U2-type catalytic step 1 spliceosome)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|interpro:IPR000504(RNA recognition motif, RNP-1)|rcsb pdb:6J6Q|dip:DIP-5164N	-	crc64:DFAF7E3B7168D944	crc64:371734A11DFDB339	figure legend:Extended Data Fig 1a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/25	2021/01/05	rogid:2bNoVkou3QatkNCtPIiSdvPdgEo559292	rogid:bCvRFfQxZ4QaBZqqOyQP7ye/UeQ559292	rigid:icMPk+gSwfNCxH1Agk9cl1QN5wQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P32639	uniprotkb:P21374	intact:EBI-861|uniprotkb:D3DM80|ensemblfungi:YER172C	intact:EBI-9382|ensemblfungi:YJR050W|uniprotkb:D6VWM1	psi-mi:brr2_yeast(display_long)|uniprotkb:BRR2(gene name)|psi-mi:BRR2(display_short)|uniprotkb:RSS1(gene name synonym)|uniprotkb:SNU246(gene name synonym)|uniprotkb:YER172C(locus name)|uniprotkb:SYGP-ORF66(orf name)|uniprotkb:Protein Snu246(gene name synonym)	psi-mi:isy1_yeast(display_long)|uniprotkb:ISY1(gene name)|psi-mi:ISY1(display_short)|uniprotkb:UTR3(gene name synonym)|uniprotkb:YJR050W(locus name)|uniprotkb:J1657(orf name)|uniprotkb:NTC30(gene name synonym)|uniprotkb:Interactor of SYF1(gene name synonym)|uniprotkb:PRP19-associated complex protein 30(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Galej et al. (2016)	imex:IM-28615|pubmed:27459055	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26571789|imex:IM-28615-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011099.1|sgd:S000000974|dip:DIP-850N|mint:P32639|ensemblfungi:YER172C(gene)|ensemblfungi:YER172C_mRNA(transcript)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|rcsb pdb:3HIB|rcsb pdb:3IM1|rcsb pdb:3IM2|rcsb pdb:3JCM|rcsb pdb:4BGD|rcsb pdb:5DCA|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GAP|rcsb pdb:5GM6|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5M52|rcsb pdb:5M5P|rcsb pdb:5NRL|rcsb pdb:5ZWM|rcsb pdb:5ZWO|rcsb pdb:7B9V	ensemblfungi:YJR050W(gene)|ensemblfungi:YJR050W_mRNA(transcript)|go:"GO:0000350"(generation of catalytic spliceosome for second transesterification step)|go:"GO:0000389"(mRNA 3'-splice site recognition)|go:"GO:0000974"(Prp19 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0071006"(U2-type catalytic step 1 spliceosome)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0071014"(post-mRNA release spliceosomal complex)|go:"GO:0071020"(post-spliceosomal complex)|interpro:IPR009360(Isy1-like splicing)|interpro:IPR029012|interpro:IPR037200|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q|reactome:R-SCE-6781823|reactome:R-SCE-6782135|reactome:R-SCE-6782210|sgd:S000003811|refseq:NP_012584.3|mint:P21374|dip:DIP-1682N	-	crc64:DFAF7E3B7168D944	-	figure legend:Extended Data Fig 1a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/25	2021/01/05	rogid:2bNoVkou3QatkNCtPIiSdvPdgEo559292	rogid:NHLAtd+wLxwtWQD8PsyzyQsfJOg559292	rigid:icMPk+gSwfNCxH1Agk9cl1QN5wQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P32639	uniprotkb:P40567	intact:EBI-861|uniprotkb:D3DM80|ensemblfungi:YER172C	intact:EBI-789|uniprotkb:D6VVT9|ensemblfungi:YIR009W	psi-mi:brr2_yeast(display_long)|uniprotkb:BRR2(gene name)|psi-mi:BRR2(display_short)|uniprotkb:RSS1(gene name synonym)|uniprotkb:SNU246(gene name synonym)|uniprotkb:YER172C(locus name)|uniprotkb:SYGP-ORF66(orf name)|uniprotkb:Protein Snu246(gene name synonym)	psi-mi:msl1_yeast(display_long)|uniprotkb:YIB9W(orf name)|uniprotkb:YIR009W(locus name)|uniprotkb:MSL1(gene name)|psi-mi:MSL1(display_short)	psi-mi:"MI:0071"(molecular sieving)	Galej et al. (2016)	imex:IM-28615|pubmed:27459055	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26571789|imex:IM-28615-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011099.1|sgd:S000000974|dip:DIP-850N|mint:P32639|ensemblfungi:YER172C(gene)|ensemblfungi:YER172C_mRNA(transcript)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|rcsb pdb:3HIB|rcsb pdb:3IM1|rcsb pdb:3IM2|rcsb pdb:3JCM|rcsb pdb:4BGD|rcsb pdb:5DCA|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GAP|rcsb pdb:5GM6|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5M52|rcsb pdb:5M5P|rcsb pdb:5NRL|rcsb pdb:5ZWM|rcsb pdb:5ZWO|rcsb pdb:7B9V	refseq:NP_012274.1|sgd:S000001448|rcsb pdb:6BK8|ensemblfungi:YIR009W(gene)|ensemblfungi:YIR009W_mRNA(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005685"(U1 snRNP)|go:"GO:0030619"(U1 snRNA binding)|go:"GO:0030620"(U2 snRNA binding)|go:"GO:0071004"(U2-type prespliceosome)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5MQ0|rcsb pdb:5NRL|rcsb pdb:5WSG|rcsb pdb:5Y88|rcsb pdb:5YLZ|rcsb pdb:5ZWM|rcsb pdb:5ZWO|dip:DIP-816N|mint:P40567|rcsb pdb:6EXN|rcsb pdb:6G90|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q	-	crc64:DFAF7E3B7168D944	-	figure legend:Extended Data Fig 1a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/25	2021/01/05	rogid:2bNoVkou3QatkNCtPIiSdvPdgEo559292	rogid:GAiHZKcbfNjbem3+i1cZXFm4NfE559292	rigid:icMPk+gSwfNCxH1Agk9cl1QN5wQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P32639	uniprotkb:P15938	intact:EBI-861|uniprotkb:D3DM80|ensemblfungi:YER172C	intact:EBI-13829|ensemblfungi:YKR086W|uniprotkb:D6VXE6	psi-mi:brr2_yeast(display_long)|uniprotkb:BRR2(gene name)|psi-mi:BRR2(display_short)|uniprotkb:RSS1(gene name synonym)|uniprotkb:SNU246(gene name synonym)|uniprotkb:YER172C(locus name)|uniprotkb:SYGP-ORF66(orf name)|uniprotkb:Protein Snu246(gene name synonym)	psi-mi:prp16_yeast(display_long)|uniprotkb:PRP16(gene name)|psi-mi:PRP16(display_short)|uniprotkb:YKR406(orf name)|uniprotkb:YKR086W(locus name)	psi-mi:"MI:0071"(molecular sieving)	Galej et al. (2016)	imex:IM-28615|pubmed:27459055	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26571789|imex:IM-28615-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011099.1|sgd:S000000974|dip:DIP-850N|mint:P32639|ensemblfungi:YER172C(gene)|ensemblfungi:YER172C_mRNA(transcript)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|rcsb pdb:3HIB|rcsb pdb:3IM1|rcsb pdb:3IM2|rcsb pdb:3JCM|rcsb pdb:4BGD|rcsb pdb:5DCA|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GAP|rcsb pdb:5GM6|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5M52|rcsb pdb:5M5P|rcsb pdb:5NRL|rcsb pdb:5ZWM|rcsb pdb:5ZWO|rcsb pdb:7B9V	ensemblfungi:YKR086W(gene)|ensemblfungi:YKR086W_mRNA(transcript)|go:"GO:0000350"(generation of catalytic spliceosome for second transesterification step)|go:"GO:0000378"(RNA exon ligation)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0008186"(ATP-dependent activity, acting on RNA)|go:"GO:0016073"(snRNA metabolic process)|go:"GO:0040031"(snRNA modification)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|interpro:IPR007502(Helicase-associated region)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR011709(Region of unknown function DUF1605)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|rcsb pdb:5LJ5|rcsb pdb:5WSG|sgd:S000001794|refseq:NP_013012.3|mint:P15938|dip:DIP-2824N	-	crc64:DFAF7E3B7168D944	-	figure legend:Extended Data Fig 1a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/25	2021/01/05	rogid:2bNoVkou3QatkNCtPIiSdvPdgEo559292	rogid:VqNrP9XJw1F9tua3l1D9XHyPOBM559292	rigid:icMPk+gSwfNCxH1Agk9cl1QN5wQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P32639	uniprotkb:P33411	intact:EBI-861|uniprotkb:D3DM80|ensemblfungi:YER172C	intact:EBI-13844|uniprotkb:Q02459|uniprotkb:Q05724|ensemblfungi:YGR006W|uniprotkb:D6VUE3	psi-mi:brr2_yeast(display_long)|uniprotkb:BRR2(gene name)|psi-mi:BRR2(display_short)|uniprotkb:RSS1(gene name synonym)|uniprotkb:SNU246(gene name synonym)|uniprotkb:YER172C(locus name)|uniprotkb:SYGP-ORF66(orf name)|uniprotkb:Protein Snu246(gene name synonym)	psi-mi:prp18_yeast(display_long)|uniprotkb:PRP18(gene name)|psi-mi:PRP18(display_short)|uniprotkb:YGR006W(locus name)	psi-mi:"MI:0071"(molecular sieving)	Galej et al. (2016)	imex:IM-28615|pubmed:27459055	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26571789|imex:IM-28615-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011099.1|sgd:S000000974|dip:DIP-850N|mint:P32639|ensemblfungi:YER172C(gene)|ensemblfungi:YER172C_mRNA(transcript)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|rcsb pdb:3HIB|rcsb pdb:3IM1|rcsb pdb:3IM2|rcsb pdb:3JCM|rcsb pdb:4BGD|rcsb pdb:5DCA|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GAP|rcsb pdb:5GM6|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5M52|rcsb pdb:5M5P|rcsb pdb:5NRL|rcsb pdb:5ZWM|rcsb pdb:5ZWO|rcsb pdb:7B9V	ensemblfungi:YGR006W(gene)|ensemblfungi:YGR006W_mRNA(transcript)|go:"GO:0000350"(generation of catalytic spliceosome for second transesterification step)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005682"(U5 snRNP)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071021"(U2-type post-spliceosomal complex)|go:"GO:0071048"|interpro:IPR004098(Prp18)|interpro:IPR039979|rcsb pdb:1DVK|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:5WSG|rcsb pdb:5YLZ|rcsb pdb:6BK8|rcsb pdb:6EXN|refseq:NP_011520.2|sgd:S000003238|mint:P33411|dip:DIP-1110N	-	crc64:DFAF7E3B7168D944	-	figure legend:Extended Data Fig 1a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/25	2021/01/05	rogid:2bNoVkou3QatkNCtPIiSdvPdgEo559292	rogid:3OaVOaHslViUjLZSTUDVIVMo4WY559292	rigid:icMPk+gSwfNCxH1Agk9cl1QN5wQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P32639	uniprotkb:P32523	intact:EBI-861|uniprotkb:D3DM80|ensemblfungi:YER172C	intact:EBI-493|uniprotkb:Q07870|ensemblfungi:YLL036C|uniprotkb:D6VXW9	psi-mi:brr2_yeast(display_long)|uniprotkb:BRR2(gene name)|psi-mi:BRR2(display_short)|uniprotkb:RSS1(gene name synonym)|uniprotkb:SNU246(gene name synonym)|uniprotkb:YER172C(locus name)|uniprotkb:SYGP-ORF66(orf name)|uniprotkb:Protein Snu246(gene name synonym)	psi-mi:prp19_yeast(display_long)|uniprotkb:PRP19(gene name)|psi-mi:PRP19(display_short)|uniprotkb:PSO4(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase PRP19(gene name synonym)|uniprotkb:YLL036C(locus name)	psi-mi:"MI:0071"(molecular sieving)	Galej et al. (2016)	imex:IM-28615|pubmed:27459055	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26571789|imex:IM-28615-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011099.1|sgd:S000000974|dip:DIP-850N|mint:P32639|ensemblfungi:YER172C(gene)|ensemblfungi:YER172C_mRNA(transcript)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|rcsb pdb:3HIB|rcsb pdb:3IM1|rcsb pdb:3IM2|rcsb pdb:3JCM|rcsb pdb:4BGD|rcsb pdb:5DCA|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GAP|rcsb pdb:5GM6|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5M52|rcsb pdb:5M5P|rcsb pdb:5NRL|rcsb pdb:5ZWM|rcsb pdb:5ZWO|rcsb pdb:7B9V	refseq:NP_013064.1|sgd:S000003959|rcsb pdb:6EXN|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q|reactome:R-SCE-6781823|reactome:R-SCE-6782135|reactome:R-SCE-6782210|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR038959|rcsb pdb:1N87|rcsb pdb:2BAY|rcsb pdb:3LRV|rcsb pdb:4ZB4|rcsb pdb:5GM6|rcsb pdb:5GMK|rcsb pdb:5LJ5|rcsb pdb:5M8C|rcsb pdb:5MQ0|ensemblfungi:YLL036C(gene)|ensemblfungi:YLL036C_mRNA(transcript)|go:"GO:0000349"(generation of catalytic spliceosome for first transesterification step)|go:"GO:0000974"(Prp19 complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0042802"(identical protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071006"(U2-type catalytic step 1 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|interpro:IPR003613(U box)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013915(Pre-mRNA-splicing factor 19)|rcsb pdb:5WSG|rcsb pdb:5Y88|rcsb pdb:5YLZ|rcsb pdb:6BK8|dip:DIP-1112N|mint:P32523	-	crc64:DFAF7E3B7168D944	crc64:A44D8C7DD6F64185	figure legend:Extended Data Fig 1a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/25	2021/01/05	rogid:2bNoVkou3QatkNCtPIiSdvPdgEo559292	rogid:/oQc2rJZ7WcCIx7cnqE6XSW/3Vk559292	rigid:icMPk+gSwfNCxH1Agk9cl1QN5wQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P32639	uniprotkb:P28004	intact:EBI-861|uniprotkb:D3DM80|ensemblfungi:YER172C	intact:EBI-20640|uniprotkb:D6VPI6|ensemblfungi:YAL032C	psi-mi:brr2_yeast(display_long)|uniprotkb:BRR2(gene name)|psi-mi:BRR2(display_short)|uniprotkb:RSS1(gene name synonym)|uniprotkb:SNU246(gene name synonym)|uniprotkb:YER172C(locus name)|uniprotkb:SYGP-ORF66(orf name)|uniprotkb:Protein Snu246(gene name synonym)	psi-mi:prp45_yeast(display_long)|uniprotkb:YAL032C(locus name)|uniprotkb:PRP45(gene name)|psi-mi:PRP45(display_short)|uniprotkb:FUN20(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Galej et al. (2016)	imex:IM-28615|pubmed:27459055	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26571789|imex:IM-28615-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011099.1|sgd:S000000974|dip:DIP-850N|mint:P32639|ensemblfungi:YER172C(gene)|ensemblfungi:YER172C_mRNA(transcript)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|rcsb pdb:3HIB|rcsb pdb:3IM1|rcsb pdb:3IM2|rcsb pdb:3JCM|rcsb pdb:4BGD|rcsb pdb:5DCA|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GAP|rcsb pdb:5GM6|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5M52|rcsb pdb:5M5P|rcsb pdb:5NRL|rcsb pdb:5ZWM|rcsb pdb:5ZWO|rcsb pdb:7B9V	refseq:NP_009370.1|sgd:S000000030|ensemblfungi:YAL032C(gene)|ensemblfungi:YAL032C_mRNA(transcript)|go:"GO:0000350"(generation of catalytic spliceosome for second transesterification step)|go:"GO:0005634"(nucleus)|go:"GO:0071006"(U2-type catalytic step 1 spliceosome)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071014"(post-mRNA release spliceosomal complex)|interpro:IPR004015(SKIP/SNW)|interpro:IPR017862|rcsb pdb:5GM6|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:5WSG|rcsb pdb:5Y88|rcsb pdb:5YLZ|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q|dip:DIP-2774N|mint:P28004	-	crc64:DFAF7E3B7168D944	crc64:FE5A724186D7FE84	figure legend:Extended Data Fig 1a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/25	2021/01/05	rogid:2bNoVkou3QatkNCtPIiSdvPdgEo559292	rogid:qoHF1UsO3k+JOTOfigSuy2P84/k559292	rigid:icMPk+gSwfNCxH1Agk9cl1QN5wQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P32639	uniprotkb:Q12417	intact:EBI-861|uniprotkb:D3DM80|ensemblfungi:YER172C	intact:EBI-710|uniprotkb:D6W3L8|ensemblfungi:YPL151C	psi-mi:brr2_yeast(display_long)|uniprotkb:BRR2(gene name)|psi-mi:BRR2(display_short)|uniprotkb:RSS1(gene name synonym)|uniprotkb:SNU246(gene name synonym)|uniprotkb:YER172C(locus name)|uniprotkb:SYGP-ORF66(orf name)|uniprotkb:Protein Snu246(gene name synonym)	psi-mi:prp46_yeast(display_long)|uniprotkb:CWC1(gene name synonym)|uniprotkb:PRP nineteen-associated complex protein 50(gene name synonym)|uniprotkb:PRP19-associated complex protein 50(gene name synonym)|uniprotkb:P2594(orf name)|uniprotkb:YPL151C(locus name)|uniprotkb:PRP46(gene name)|psi-mi:PRP46(display_short)|uniprotkb:NTC50(gene name synonym)|uniprotkb:Pre-mRNA-processing protein 46(gene name synonym)|uniprotkb:Complexed with CEF1 protein 1(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Galej et al. (2016)	imex:IM-28615|pubmed:27459055	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26571789|imex:IM-28615-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011099.1|sgd:S000000974|dip:DIP-850N|mint:P32639|ensemblfungi:YER172C(gene)|ensemblfungi:YER172C_mRNA(transcript)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|rcsb pdb:3HIB|rcsb pdb:3IM1|rcsb pdb:3IM2|rcsb pdb:3JCM|rcsb pdb:4BGD|rcsb pdb:5DCA|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GAP|rcsb pdb:5GM6|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5M52|rcsb pdb:5M5P|rcsb pdb:5NRL|rcsb pdb:5ZWM|rcsb pdb:5ZWO|rcsb pdb:7B9V	refseq:NP_015174.1|sgd:S000006072|ensemblfungi:YPL151C(gene)|ensemblfungi:YPL151C_mRNA(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000974"(Prp19 complex)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|dip:DIP-3994N|mint:Q12417|rcsb pdb:5GM6|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:5WSG|rcsb pdb:5Y88|rcsb pdb:5YLZ|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q	-	crc64:DFAF7E3B7168D944	crc64:0E888F566A5414BD	figure legend:Extended Data Fig 1a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/25	2021/01/05	rogid:2bNoVkou3QatkNCtPIiSdvPdgEo559292	rogid:016ynVER9V3d44NwkqRG7TIvf9w559292	rigid:icMPk+gSwfNCxH1Agk9cl1QN5wQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P32639	uniprotkb:P33334	intact:EBI-861|uniprotkb:D3DM80|ensemblfungi:YER172C	intact:EBI-465|uniprotkb:D3DLB4|ensemblfungi:YHR165C	psi-mi:brr2_yeast(display_long)|uniprotkb:BRR2(gene name)|psi-mi:BRR2(display_short)|uniprotkb:RSS1(gene name synonym)|uniprotkb:SNU246(gene name synonym)|uniprotkb:YER172C(locus name)|uniprotkb:SYGP-ORF66(orf name)|uniprotkb:Protein Snu246(gene name synonym)	psi-mi:prp8_yeast(display_long)|uniprotkb:PRP8(gene name)|psi-mi:PRP8(display_short)|uniprotkb:DBF3(gene name synonym)|uniprotkb:DNA39(gene name synonym)|uniprotkb:RNA8(gene name synonym)|uniprotkb:SLT21(gene name synonym)|uniprotkb:USA2(gene name synonym)|uniprotkb:YHR165C(locus name)	psi-mi:"MI:0071"(molecular sieving)	Galej et al. (2016)	imex:IM-28615|pubmed:27459055	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26571789|imex:IM-28615-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011099.1|sgd:S000000974|dip:DIP-850N|mint:P32639|ensemblfungi:YER172C(gene)|ensemblfungi:YER172C_mRNA(transcript)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|rcsb pdb:3HIB|rcsb pdb:3IM1|rcsb pdb:3IM2|rcsb pdb:3JCM|rcsb pdb:4BGD|rcsb pdb:5DCA|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GAP|rcsb pdb:5GM6|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5M52|rcsb pdb:5M5P|rcsb pdb:5NRL|rcsb pdb:5ZWM|rcsb pdb:5ZWO|rcsb pdb:7B9V	refseq:NP_012035.1|sgd:S000001208|rcsb pdb:4ILJ|rcsb pdb:5DCA|rcsb pdb:5GAM|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GAP|rcsb pdb:5GM6|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5M52|rcsb pdb:5M5P|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:5NRL|rcsb pdb:5QY1|rcsb pdb:5QY2|rcsb pdb:5QY3|rcsb pdb:5QY4|rcsb pdb:5QY5|rcsb pdb:5QY6|rcsb pdb:5QY7|rcsb pdb:5QY8|rcsb pdb:5QY9|rcsb pdb:5QYA|rcsb pdb:5QYB|rcsb pdb:5QYC|rcsb pdb:5QYD|rcsb pdb:5QYE|rcsb pdb:5QYF|rcsb pdb:5QYG|rcsb pdb:5QYH|rcsb pdb:5QYI|rcsb pdb:5QYJ|rcsb pdb:5QYK|rcsb pdb:5QYL|rcsb pdb:5QYM|rcsb pdb:5QYN|rcsb pdb:5QYO|rcsb pdb:5QYP|rcsb pdb:5QYQ|rcsb pdb:5QYR|rcsb pdb:5QYS|rcsb pdb:5QYT|rcsb pdb:5QYU|rcsb pdb:5QYV|rcsb pdb:5QYW|rcsb pdb:5QYX|rcsb pdb:5QYY|rcsb pdb:5QYZ|rcsb pdb:5QZ0|rcsb pdb:5QZ1|rcsb pdb:5QZ2|rcsb pdb:5QZ3|rcsb pdb:5QZ4|rcsb pdb:5QZ5|rcsb pdb:5QZ6|rcsb pdb:5QZ7|rcsb pdb:5QZ8|rcsb pdb:5QZ9|rcsb pdb:5QZA|rcsb pdb:5QZB|rcsb pdb:5QZC|rcsb pdb:5QZD|rcsb pdb:5QZE|rcsb pdb:5QZF|rcsb pdb:5QZG|rcsb pdb:5QZH|rcsb pdb:5QZI|rcsb pdb:5QZJ|rcsb pdb:5QZK|rcsb pdb:5QZL|rcsb pdb:5QZM|rcsb pdb:5QZN|rcsb pdb:5QZO|rcsb pdb:5QZP|rcsb pdb:5R14|rcsb pdb:5R15|rcsb pdb:5R16|rcsb pdb:5R17|rcsb pdb:5R18|rcsb pdb:5R19|rcsb pdb:5R1A|rcsb pdb:5R1B|rcsb pdb:5R1C|rcsb pdb:5R1D|rcsb pdb:5R1E|rcsb pdb:5R1F|rcsb pdb:5R1G|rcsb pdb:5R1H|rcsb pdb:5R1I|rcsb pdb:5R1J|rcsb pdb:5R1K|rcsb pdb:5R1L|rcsb pdb:5R1M|rcsb pdb:5R1N|rcsb pdb:5R1O|rcsb pdb:5R1P|rcsb pdb:5R1Q|rcsb pdb:5R1S|rcsb pdb:5WSG|rcsb pdb:5Y88|rcsb pdb:5YLZ|rcsb pdb:5ZWM|rcsb pdb:5ZWO|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q|rcsb pdb:6TEO|rcsb pdb:7B9V|rcsb pdb:5QZQ|rcsb pdb:5QZR|rcsb pdb:5QZS|rcsb pdb:5QZT|rcsb pdb:5QZU|rcsb pdb:5QZV|rcsb pdb:5QZW|rcsb pdb:5QZX|rcsb pdb:5QZY|rcsb pdb:5QZZ|rcsb pdb:5R00|rcsb pdb:5R01|rcsb pdb:5R02|rcsb pdb:5R03|rcsb pdb:5R04|rcsb pdb:5R05|rcsb pdb:5R06|rcsb pdb:5R07|rcsb pdb:5R08|rcsb pdb:5R09|rcsb pdb:5R0A|rcsb pdb:5R0B|rcsb pdb:5R0C|rcsb pdb:5R0D|rcsb pdb:5R0E|rcsb pdb:5R0F|rcsb pdb:5R0G|rcsb pdb:5R0H|rcsb pdb:5R0I|rcsb pdb:5R0J|rcsb pdb:5R0K|rcsb pdb:5R0L|rcsb pdb:5R0M|rcsb pdb:5R0N|rcsb pdb:5R0O|rcsb pdb:5R0P|rcsb pdb:5R0Q|rcsb pdb:5R0R|rcsb pdb:5R0S|rcsb pdb:5R0T|rcsb pdb:5R0U|rcsb pdb:5R0V|rcsb pdb:5R0W|rcsb pdb:5R0X|rcsb pdb:5R0Y|rcsb pdb:5R0Z|rcsb pdb:5R10|rcsb pdb:5R11|rcsb pdb:5R12|rcsb pdb:5R13|ensemblfungi:YHR165C(gene)|ensemblfungi:YHR165C_mRNA(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000350"(generation of catalytic spliceosome for second transesterification step)|go:"GO:0000389"(mRNA 3'-splice site recognition)|go:"GO:0000395"(mRNA 5'-splice site recognition)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005682"(U5 snRNP)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0030619"(U1 snRNA binding)|go:"GO:0030620"(U2 snRNA binding)|go:"GO:0030623"(U5 snRNA binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0071013"(catalytic step 2 spliceosome)|rcsb pdb:3SBT|rcsb pdb:3ZEF|rcsb pdb:4BGD|rcsb pdb:4I43|go:"GO:0097157"(pre-mRNA intronic binding)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR012591(PRO8NT)|interpro:IPR012592(PROCN)|interpro:IPR012984(PRO, C-terminal)|interpro:IPR019580|interpro:IPR019581|interpro:IPR019582|interpro:IPR021983|interpro:IPR027652|interpro:IPR037518|interpro:IPR042516|interpro:IPR043172|interpro:IPR043173|rcsb pdb:2OG4|rcsb pdb:3E66|rcsb pdb:3E9O|rcsb pdb:3E9P|rcsb pdb:3JCM|rcsb pdb:3SBG|rcsb pdb:4ILG|rcsb pdb:4ILH|dip:DIP-2427N|mint:P33334	-	crc64:DFAF7E3B7168D944	crc64:8F4F6F89D34D3508	figure legend:Extended Data Fig 1a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/25	2021/01/05	rogid:2bNoVkou3QatkNCtPIiSdvPdgEo559292	rogid:0JoVp7ULlbib7N5+GOPksHStSmY559292	rigid:icMPk+gSwfNCxH1Agk9cl1QN5wQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P32639	uniprotkb:P40018	intact:EBI-861|uniprotkb:D3DM80|ensemblfungi:YER172C	intact:EBI-432|uniprotkb:D3DLS8|ensemblfungi:YER029C	psi-mi:brr2_yeast(display_long)|uniprotkb:BRR2(gene name)|psi-mi:BRR2(display_short)|uniprotkb:RSS1(gene name synonym)|uniprotkb:SNU246(gene name synonym)|uniprotkb:YER172C(locus name)|uniprotkb:SYGP-ORF66(orf name)|uniprotkb:Protein Snu246(gene name synonym)	psi-mi:rsmb_yeast(display_long)|uniprotkb:SMB1(gene name)|psi-mi:SMB1(display_short)|uniprotkb:Sm protein B(gene name synonym)|uniprotkb:YER029C(locus name)	psi-mi:"MI:0071"(molecular sieving)	Galej et al. (2016)	imex:IM-28615|pubmed:27459055	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26571789|imex:IM-28615-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011099.1|sgd:S000000974|dip:DIP-850N|mint:P32639|ensemblfungi:YER172C(gene)|ensemblfungi:YER172C_mRNA(transcript)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|rcsb pdb:3HIB|rcsb pdb:3IM1|rcsb pdb:3IM2|rcsb pdb:3JCM|rcsb pdb:4BGD|rcsb pdb:5DCA|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GAP|rcsb pdb:5GM6|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5M52|rcsb pdb:5M5P|rcsb pdb:5NRL|rcsb pdb:5ZWM|rcsb pdb:5ZWO|rcsb pdb:7B9V	sgd:S000000831|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:5NRL|rcsb pdb:5WSG|rcsb pdb:5Y88|rcsb pdb:5YLZ|rcsb pdb:5ZWM|rcsb pdb:5ZWN|rcsb pdb:5ZWO|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:6G90|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q|rcsb pdb:6N7P|rcsb pdb:6N7R|rcsb pdb:6N7X|rcsb pdb:7B9V|ensemblfungi:YER029C(gene)|ensemblfungi:YER029C_mRNA(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005682"(U5 snRNP)|go:"GO:0005685"(U1 snRNP)|go:"GO:0005686"(U2 snRNP)|go:"GO:0005687"(U4 snRNP)|go:"GO:0005737"(cytoplasm)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071004"(U2-type prespliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|rcsb pdb:3JCM|rcsb pdb:5GAM|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GM6|refseq:NP_010946.3|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5LQW|dip:DIP-843N|mint:P40018	-	crc64:DFAF7E3B7168D944	crc64:0A1078D5AA241430	figure legend:Extended Data Fig 1a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/25	2021/01/05	rogid:2bNoVkou3QatkNCtPIiSdvPdgEo559292	rogid:b62+dBOdvQgeE0oup4kbXbviS1U559292	rigid:icMPk+gSwfNCxH1Agk9cl1QN5wQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P32639	uniprotkb:Q08963	intact:EBI-861|uniprotkb:D3DM80|ensemblfungi:YER172C	intact:EBI-594|uniprotkb:D6W3F7|ensemblfungi:YPL213W	psi-mi:brr2_yeast(display_long)|uniprotkb:BRR2(gene name)|psi-mi:BRR2(display_short)|uniprotkb:RSS1(gene name synonym)|uniprotkb:SNU246(gene name synonym)|uniprotkb:YER172C(locus name)|uniprotkb:SYGP-ORF66(orf name)|uniprotkb:Protein Snu246(gene name synonym)	psi-mi:ru2a_yeast(display_long)|uniprotkb:YPL213W(locus name)|uniprotkb:LEA1(gene name)|psi-mi:LEA1(display_short)|uniprotkb:Looks exceptionally like U2A protein 1(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Galej et al. (2016)	imex:IM-28615|pubmed:27459055	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26571789|imex:IM-28615-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011099.1|sgd:S000000974|dip:DIP-850N|mint:P32639|ensemblfungi:YER172C(gene)|ensemblfungi:YER172C_mRNA(transcript)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|rcsb pdb:3HIB|rcsb pdb:3IM1|rcsb pdb:3IM2|rcsb pdb:3JCM|rcsb pdb:4BGD|rcsb pdb:5DCA|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GAP|rcsb pdb:5GM6|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5M52|rcsb pdb:5M5P|rcsb pdb:5NRL|rcsb pdb:5ZWM|rcsb pdb:5ZWO|rcsb pdb:7B9V	refseq:NP_015111.1|sgd:S000006134|dip:DIP-2399N|mint:Q08963|ensemblfungi:YPL213W(gene)|ensemblfungi:YPL213W_mRNA(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005686"(U2 snRNP)|go:"GO:0005737"(cytoplasm)|go:"GO:0030620"(U2 snRNA binding)|go:"GO:0071004"(U2-type prespliceosome)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003603(U2A'/phosphoprotein 32 family A, C-terminal)|interpro:IPR032675|interpro:IPR044640|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5MQ0|rcsb pdb:5NRL|rcsb pdb:5WSG|rcsb pdb:5Y88|rcsb pdb:5YLZ|rcsb pdb:5ZWM|rcsb pdb:5ZWO|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:6G90|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q	-	crc64:DFAF7E3B7168D944	-	figure legend:Extended Data Fig 1a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/25	2021/01/05	rogid:2bNoVkou3QatkNCtPIiSdvPdgEo559292	rogid:PlKwD+gRYbhUBE4GcxTaP0wt8zM559292	rigid:icMPk+gSwfNCxH1Agk9cl1QN5wQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P32639	uniprotkb:Q12330	intact:EBI-861|uniprotkb:D3DM80|ensemblfungi:YER172C	intact:EBI-16359|uniprotkb:D6W2L6|ensemblfungi:YOR159C	psi-mi:brr2_yeast(display_long)|uniprotkb:BRR2(gene name)|psi-mi:BRR2(display_short)|uniprotkb:RSS1(gene name synonym)|uniprotkb:SNU246(gene name synonym)|uniprotkb:YER172C(locus name)|uniprotkb:SYGP-ORF66(orf name)|uniprotkb:Protein Snu246(gene name synonym)	psi-mi:ruxe_yeast(display_long)|uniprotkb:SME1(gene name)|psi-mi:SME1(display_short)|uniprotkb:YOR159C(locus name)|uniprotkb:Sm protein E(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Galej et al. (2016)	imex:IM-28615|pubmed:27459055	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26571789|imex:IM-28615-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011099.1|sgd:S000000974|dip:DIP-850N|mint:P32639|ensemblfungi:YER172C(gene)|ensemblfungi:YER172C_mRNA(transcript)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|rcsb pdb:3HIB|rcsb pdb:3IM1|rcsb pdb:3IM2|rcsb pdb:3JCM|rcsb pdb:4BGD|rcsb pdb:5DCA|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GAP|rcsb pdb:5GM6|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5M52|rcsb pdb:5M5P|rcsb pdb:5NRL|rcsb pdb:5ZWM|rcsb pdb:5ZWO|rcsb pdb:7B9V	ensemblfungi:YOR159C(gene)|ensemblfungi:YOR159C_mRNA(transcript)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005682"(U5 snRNP)|go:"GO:0005685"(U1 snRNP)|go:"GO:0005686"(U2 snRNP)|go:"GO:0005687"(U4 snRNP)|go:"GO:0005737"(cytoplasm)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071004"(U2-type prespliceosome)|go:"GO:0071011"(precatalytic spliceosome)|go:"GO:1990935"(splicing factor binding)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR027078|rcsb pdb:3JCM|rcsb pdb:5GAM|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GM6|rcsb pdb:5GMK|sgd:S000005685|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:5NRL|rcsb pdb:5WSG|rcsb pdb:5Y88|rcsb pdb:5YLZ|rcsb pdb:5ZWM|rcsb pdb:5ZWN|rcsb pdb:5ZWO|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:6G90|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q|rcsb pdb:6N7P|rcsb pdb:6N7R|rcsb pdb:6N7X|rcsb pdb:7B9V|refseq:NP_014802.3|dip:DIP-1633N|mint:Q12330	-	crc64:DFAF7E3B7168D944	crc64:B76D72DA8456F3B5	figure legend:Extended Data Fig 1a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/25	2021/01/05	rogid:2bNoVkou3QatkNCtPIiSdvPdgEo559292	rogid:IiV/AXz4zJjC7A2iuBixxiLYo9E559292	rigid:icMPk+gSwfNCxH1Agk9cl1QN5wQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P32639	uniprotkb:P54999	intact:EBI-861|uniprotkb:D3DM80|ensemblfungi:YER172C	intact:EBI-770|uniprotkb:D6W4I2|ensemblfungi:YPR182W	psi-mi:brr2_yeast(display_long)|uniprotkb:BRR2(gene name)|psi-mi:BRR2(display_short)|uniprotkb:RSS1(gene name synonym)|uniprotkb:SNU246(gene name synonym)|uniprotkb:YER172C(locus name)|uniprotkb:SYGP-ORF66(orf name)|uniprotkb:Protein Snu246(gene name synonym)	psi-mi:ruxf_yeast(display_long)|uniprotkb:SMX3(gene name)|psi-mi:SMX3(display_short)|uniprotkb:YPR182W(locus name)|uniprotkb:P9705.4(orf name)|uniprotkb:Sm protein F(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Galej et al. (2016)	imex:IM-28615|pubmed:27459055	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26571789|imex:IM-28615-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011099.1|sgd:S000000974|dip:DIP-850N|mint:P32639|ensemblfungi:YER172C(gene)|ensemblfungi:YER172C_mRNA(transcript)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|rcsb pdb:3HIB|rcsb pdb:3IM1|rcsb pdb:3IM2|rcsb pdb:3JCM|rcsb pdb:4BGD|rcsb pdb:5DCA|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GAP|rcsb pdb:5GM6|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5M52|rcsb pdb:5M5P|rcsb pdb:5NRL|rcsb pdb:5ZWM|rcsb pdb:5ZWO|rcsb pdb:7B9V	refseq:NP_015508.1|sgd:S000006386|dip:DIP-1634N|mint:P54999|ensemblfungi:YPR182W(gene)|ensemblfungi:YPR182W_mRNA(transcript)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005682"(U5 snRNP)|go:"GO:0005685"(U1 snRNP)|go:"GO:0005686"(U2 snRNP)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1990935"(splicing factor binding)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR016487(Small nuclear ribonucleoprotein SmF)|interpro:IPR034100|rcsb pdb:1N9R|rcsb pdb:1N9S|rcsb pdb:3JCM|rcsb pdb:5GAM|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GM6|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:5NRL|rcsb pdb:5WSG|rcsb pdb:5Y88|rcsb pdb:5YLZ|rcsb pdb:5ZWM|rcsb pdb:5ZWN|rcsb pdb:5ZWO|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:6G90|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q|rcsb pdb:6N7P|rcsb pdb:6N7R|rcsb pdb:6N7X|rcsb pdb:7B9V	-	crc64:DFAF7E3B7168D944	crc64:1640D3237597B2D8	figure legend:Extended Data Fig 1a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/25	2021/01/05	rogid:2bNoVkou3QatkNCtPIiSdvPdgEo559292	rogid:iyBbVNf2fgOIqhnOg9Etn3P2r3Q559292	rigid:icMPk+gSwfNCxH1Agk9cl1QN5wQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P32639	uniprotkb:P40204	intact:EBI-861|uniprotkb:D3DM80|ensemblfungi:YER172C	intact:EBI-637|uniprotkb:D6VTL2|ensemblfungi:YFL017W-A	psi-mi:brr2_yeast(display_long)|uniprotkb:BRR2(gene name)|psi-mi:BRR2(display_short)|uniprotkb:RSS1(gene name synonym)|uniprotkb:SNU246(gene name synonym)|uniprotkb:YER172C(locus name)|uniprotkb:SYGP-ORF66(orf name)|uniprotkb:Protein Snu246(gene name synonym)	psi-mi:ruxg_yeast(display_long)|uniprotkb:SNP2(gene name synonym)|uniprotkb:YFL017Bw(orf name)|uniprotkb:YFL017W-A(locus name)|uniprotkb:SMX2(gene name)|psi-mi:SMX2(display_short)|uniprotkb:Sm protein G(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Galej et al. (2016)	imex:IM-28615|pubmed:27459055	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26571789|imex:IM-28615-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011099.1|sgd:S000000974|dip:DIP-850N|mint:P32639|ensemblfungi:YER172C(gene)|ensemblfungi:YER172C_mRNA(transcript)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|rcsb pdb:3HIB|rcsb pdb:3IM1|rcsb pdb:3IM2|rcsb pdb:3JCM|rcsb pdb:4BGD|rcsb pdb:5DCA|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GAP|rcsb pdb:5GM6|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5M52|rcsb pdb:5M5P|rcsb pdb:5NRL|rcsb pdb:5ZWM|rcsb pdb:5ZWO|rcsb pdb:7B9V	refseq:NP_116636.1|sgd:S000002965|dip:DIP-6683N|mint:P40204|ensemblfungi:YFL017W-A(gene)|ensemblfungi:YFL017W-A_mRNA(transcript)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005682"(U5 snRNP)|go:"GO:0005685"(U1 snRNP)|go:"GO:0005686"(U2 snRNP)|go:"GO:0005687"(U4 snRNP)|go:"GO:0005689"(U12-type spliceosomal complex)|go:"GO:0034719"(SMN-Sm protein complex)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071004"(U2-type prespliceosome)|go:"GO:0071011"(precatalytic spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0097526"(spliceosomal tri-snRNP complex)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR034098|interpro:IPR044641|rcsb pdb:3JCM|rcsb pdb:5GAM|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GM6|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:5NRL|rcsb pdb:5WSG|rcsb pdb:5Y88|rcsb pdb:5YLZ|rcsb pdb:5ZWM|rcsb pdb:5ZWN|rcsb pdb:5ZWO|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:6G90|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q|rcsb pdb:6N7P|rcsb pdb:6N7R|rcsb pdb:6N7X|rcsb pdb:7B9V|rcsb pdb:7DCO	-	crc64:DFAF7E3B7168D944	crc64:5C6208B8C5A9AB33	figure legend:Extended Data Fig 1a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/25	2021/01/05	rogid:2bNoVkou3QatkNCtPIiSdvPdgEo559292	rogid:Wh37rGoSJFpJ5o+CuNkBnpiu/5s559292	rigid:icMPk+gSwfNCxH1Agk9cl1QN5wQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P32639	uniprotkb:P38241	intact:EBI-861|uniprotkb:D3DM80|ensemblfungi:YER172C	intact:EBI-780|uniprotkb:P89497|uniprotkb:D6VQ64|ensemblfungi:YBR065C	psi-mi:brr2_yeast(display_long)|uniprotkb:BRR2(gene name)|psi-mi:BRR2(display_short)|uniprotkb:RSS1(gene name synonym)|uniprotkb:SNU246(gene name synonym)|uniprotkb:YER172C(locus name)|uniprotkb:SYGP-ORF66(orf name)|uniprotkb:Protein Snu246(gene name synonym)	psi-mi:slt11_yeast(display_long)|uniprotkb:ECM2(gene name)|psi-mi:ECM2(display_short)|uniprotkb:SLT11(gene name synonym)|uniprotkb:YBR065C(locus name)|uniprotkb:YBR0614(orf name)|uniprotkb:Synthetic lethality with U2 protein 11(gene name synonym)|uniprotkb:Extracellular mutant protein 2(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Galej et al. (2016)	imex:IM-28615|pubmed:27459055	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26571789|imex:IM-28615-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011099.1|sgd:S000000974|dip:DIP-850N|mint:P32639|ensemblfungi:YER172C(gene)|ensemblfungi:YER172C_mRNA(transcript)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|rcsb pdb:3HIB|rcsb pdb:3IM1|rcsb pdb:3IM2|rcsb pdb:3JCM|rcsb pdb:4BGD|rcsb pdb:5DCA|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GAP|rcsb pdb:5GM6|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5M52|rcsb pdb:5M5P|rcsb pdb:5NRL|rcsb pdb:5ZWM|rcsb pdb:5ZWO|rcsb pdb:7B9V	sgd:S000000269|refseq:NP_009621.3|dip:DIP-5359N|mint:P38241|ensemblfungi:YBR065C(gene)|ensemblfungi:YBR065C_mRNA(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000974"(Prp19 complex)|go:"GO:0005634"(nucleus)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0071006"(U2-type catalytic step 1 spliceosome)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|interpro:IPR034356|interpro:IPR039171|rcsb pdb:5GM6|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:5WSG|rcsb pdb:5Y88|rcsb pdb:5YLZ|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q	-	crc64:DFAF7E3B7168D944	crc64:BF21E687817A42B4	figure legend:Extended Data Fig 1a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/25	2021/01/05	rogid:2bNoVkou3QatkNCtPIiSdvPdgEo559292	rogid:ioGlVp9msutMpWXME0tICQn8GDQ559292	rigid:icMPk+gSwfNCxH1Agk9cl1QN5wQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P32639	uniprotkb:Q02775	intact:EBI-861|uniprotkb:D3DM80|ensemblfungi:YER172C	intact:EBI-17379|uniprotkb:P89902|uniprotkb:Q6Q5U3|uniprotkb:D6VS75|ensemblfungi:YDR088C	psi-mi:brr2_yeast(display_long)|uniprotkb:BRR2(gene name)|psi-mi:BRR2(display_short)|uniprotkb:RSS1(gene name synonym)|uniprotkb:SNU246(gene name synonym)|uniprotkb:YER172C(locus name)|uniprotkb:SYGP-ORF66(orf name)|uniprotkb:Protein Snu246(gene name synonym)	psi-mi:slu7_yeast(display_long)|uniprotkb:SLU7(gene name)|psi-mi:SLU7(display_short)|uniprotkb:YDR088C(locus name)|uniprotkb:D4483(orf name)|uniprotkb:SLT17(gene name synonym)|uniprotkb:Synthetic lethal with U5 snRNA protein 7(gene name synonym)|uniprotkb:Synthetic lethal with U2 snRNA protein 17(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Galej et al. (2016)	imex:IM-28615|pubmed:27459055	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26571789|imex:IM-28615-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011099.1|sgd:S000000974|dip:DIP-850N|mint:P32639|ensemblfungi:YER172C(gene)|ensemblfungi:YER172C_mRNA(transcript)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|rcsb pdb:3HIB|rcsb pdb:3IM1|rcsb pdb:3IM2|rcsb pdb:3JCM|rcsb pdb:4BGD|rcsb pdb:5DCA|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GAP|rcsb pdb:5GM6|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5M52|rcsb pdb:5M5P|rcsb pdb:5NRL|rcsb pdb:5ZWM|rcsb pdb:5ZWO|rcsb pdb:7B9V	refseq:NP_010373.3|sgd:S000002495|ensemblfungi:YDR088C(gene)|ensemblfungi:YDR088C_mRNA(transcript)|go:"GO:0000350"(generation of catalytic spliceosome for second transesterification step)|go:"GO:0000386"(second spliceosomal transesterification activity)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0030628"(pre-mRNA 3'-splice site binding)|go:"GO:0071021"(U2-type post-spliceosomal complex)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR021715|interpro:IPR036875|interpro:IPR039974|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:5YLZ|mint:Q02775|dip:DIP-220N	-	crc64:DFAF7E3B7168D944	crc64:6405458FC367A7D3	figure legend:Extended Data Fig 1a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/25	2021/01/05	rogid:2bNoVkou3QatkNCtPIiSdvPdgEo559292	rogid:an3IJpPrRlLX0cALtTMg4C2JxUI559292	rigid:icMPk+gSwfNCxH1Agk9cl1QN5wQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P32639	uniprotkb:Q02260	intact:EBI-861|uniprotkb:D3DM80|ensemblfungi:YER172C	intact:EBI-585|uniprotkb:D6VUK6|ensemblfungi:YGR074W	psi-mi:brr2_yeast(display_long)|uniprotkb:BRR2(gene name)|psi-mi:BRR2(display_short)|uniprotkb:RSS1(gene name synonym)|uniprotkb:SNU246(gene name synonym)|uniprotkb:YER172C(locus name)|uniprotkb:SYGP-ORF66(orf name)|uniprotkb:Protein Snu246(gene name synonym)	psi-mi:smd1_yeast(display_long)|uniprotkb:YGR074W(locus name)|uniprotkb:SMD1(gene name)|psi-mi:SMD1(display_short)|uniprotkb:snRNP core protein D1(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Galej et al. (2016)	imex:IM-28615|pubmed:27459055	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26571789|imex:IM-28615-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011099.1|sgd:S000000974|dip:DIP-850N|mint:P32639|ensemblfungi:YER172C(gene)|ensemblfungi:YER172C_mRNA(transcript)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|rcsb pdb:3HIB|rcsb pdb:3IM1|rcsb pdb:3IM2|rcsb pdb:3JCM|rcsb pdb:4BGD|rcsb pdb:5DCA|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GAP|rcsb pdb:5GM6|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5M52|rcsb pdb:5M5P|rcsb pdb:5NRL|rcsb pdb:5ZWM|rcsb pdb:5ZWO|rcsb pdb:7B9V	sgd:S000003306|refseq:NP_011588.3|dip:DIP-227N|mint:Q02260|ensemblfungi:YGR074W(gene)|ensemblfungi:YGR074W_mRNA(transcript)|go:"GO:0000243"(commitment complex)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005682"(U5 snRNP)|go:"GO:0005685"(U1 snRNP)|go:"GO:0005686"(U2 snRNP)|go:"GO:0005689"(U12-type spliceosomal complex)|go:"GO:0005829"(cytosol)|go:"GO:0030532"(small nuclear ribonucleoprotein complex)|go:"GO:0034715"(pICln-Sm protein complex)|go:"GO:0005687"(U4 snRNP)|go:"GO:0034719"(SMN-Sm protein complex)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071004"(U2-type prespliceosome)|go:"GO:0071011"(precatalytic spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0097526"(spliceosomal tri-snRNP complex)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR027141|rcsb pdb:3JCM|rcsb pdb:5GAM|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GM6|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:5NRL|rcsb pdb:5WSG|rcsb pdb:5Y88|rcsb pdb:5YLZ|rcsb pdb:5ZWM|rcsb pdb:5ZWN|rcsb pdb:5ZWO|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:6G90|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q|rcsb pdb:6N7P|rcsb pdb:6N7R|rcsb pdb:6N7X|rcsb pdb:7B9V	-	crc64:DFAF7E3B7168D944	crc64:9929F21EB9218447	figure legend:Extended Data Fig 1a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/25	2021/01/05	rogid:2bNoVkou3QatkNCtPIiSdvPdgEo559292	rogid:SvOKDbY05xgJXKZ8uS+keXsC41I559292	rigid:icMPk+gSwfNCxH1Agk9cl1QN5wQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P32639	uniprotkb:Q06217	intact:EBI-861|uniprotkb:D3DM80|ensemblfungi:YER172C	intact:EBI-235|uniprotkb:D6VYS2|ensemblfungi:YLR275W	psi-mi:brr2_yeast(display_long)|uniprotkb:BRR2(gene name)|psi-mi:BRR2(display_short)|uniprotkb:RSS1(gene name synonym)|uniprotkb:SNU246(gene name synonym)|uniprotkb:YER172C(locus name)|uniprotkb:SYGP-ORF66(orf name)|uniprotkb:Protein Snu246(gene name synonym)	psi-mi:smd2_yeast(display_long)|uniprotkb:SMD2(gene name)|psi-mi:SMD2(display_short)|uniprotkb:YLR275W(locus name)|uniprotkb:L9328.5(orf name)|uniprotkb:snRNP core protein D2(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Galej et al. (2016)	imex:IM-28615|pubmed:27459055	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26571789|imex:IM-28615-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011099.1|sgd:S000000974|dip:DIP-850N|mint:P32639|ensemblfungi:YER172C(gene)|ensemblfungi:YER172C_mRNA(transcript)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|rcsb pdb:3HIB|rcsb pdb:3IM1|rcsb pdb:3IM2|rcsb pdb:3JCM|rcsb pdb:4BGD|rcsb pdb:5DCA|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GAP|rcsb pdb:5GM6|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5M52|rcsb pdb:5M5P|rcsb pdb:5NRL|rcsb pdb:5ZWM|rcsb pdb:5ZWO|rcsb pdb:7B9V	sgd:S000004265|refseq:NP_013377.1|mint:Q06217|dip:DIP-1421N|ensemblfungi:YLR275W(gene)|ensemblfungi:YLR275W_mRNA(transcript)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0003723"(RNA binding)|go:"GO:0005682"(U5 snRNP)|go:"GO:0005685"(U1 snRNP)|go:"GO:0005686"(U2 snRNP)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071004"(U2-type prespliceosome)|go:"GO:0071011"(precatalytic spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR027248|rcsb pdb:3JCM|rcsb pdb:5GAM|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GM6|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:5NRL|rcsb pdb:5WSG|rcsb pdb:5Y88|rcsb pdb:5YLZ|rcsb pdb:5ZWM|rcsb pdb:5ZWN|rcsb pdb:5ZWO|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:6G90|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q|rcsb pdb:6N7P|rcsb pdb:6N7R|rcsb pdb:6N7X|rcsb pdb:7B9V	-	crc64:DFAF7E3B7168D944	crc64:7287070B10E090C0	figure legend:Extended Data Fig 1a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/25	2021/01/05	rogid:2bNoVkou3QatkNCtPIiSdvPdgEo559292	rogid:rglZ3AQuJfa1rFYIeZLqiYj+L4U559292	rigid:icMPk+gSwfNCxH1Agk9cl1QN5wQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P32639	uniprotkb:P43321	intact:EBI-861|uniprotkb:D3DM80|ensemblfungi:YER172C	intact:EBI-529|ensemblfungi:YLR147C|uniprotkb:D6VYE2|uniprotkb:E9P8W3	psi-mi:brr2_yeast(display_long)|uniprotkb:BRR2(gene name)|psi-mi:BRR2(display_short)|uniprotkb:RSS1(gene name synonym)|uniprotkb:SNU246(gene name synonym)|uniprotkb:YER172C(locus name)|uniprotkb:SYGP-ORF66(orf name)|uniprotkb:Protein Snu246(gene name synonym)	psi-mi:smd3_yeast(display_long)|uniprotkb:SMD3(gene name)|psi-mi:SMD3(display_short)|uniprotkb:YLR147C(locus name)|uniprotkb:L9634.6(orf name)|uniprotkb:snRNP core protein D3(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Galej et al. (2016)	imex:IM-28615|pubmed:27459055	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26571789|imex:IM-28615-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011099.1|sgd:S000000974|dip:DIP-850N|mint:P32639|ensemblfungi:YER172C(gene)|ensemblfungi:YER172C_mRNA(transcript)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|rcsb pdb:3HIB|rcsb pdb:3IM1|rcsb pdb:3IM2|rcsb pdb:3JCM|rcsb pdb:4BGD|rcsb pdb:5DCA|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GAP|rcsb pdb:5GM6|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5M52|rcsb pdb:5M5P|rcsb pdb:5NRL|rcsb pdb:5ZWM|rcsb pdb:5ZWO|rcsb pdb:7B9V	refseq:NP_013248.1|sgd:S000004137|rcsb pdb:5YLZ|rcsb pdb:5ZWM|rcsb pdb:5ZWN|rcsb pdb:5ZWO|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:6G90|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q|rcsb pdb:6N7P|rcsb pdb:6N7R|rcsb pdb:6N7X|rcsb pdb:7B9V|ensemblfungi:YLR147C(gene)|ensemblfungi:YLR147C_mRNA(transcript)|go:"GO:0000243"(commitment complex)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005682"(U5 snRNP)|go:"GO:0005685"(U1 snRNP)|go:"GO:0005686"(U2 snRNP)|go:"GO:0005687"(U4 snRNP)|go:"GO:0005689"(U12-type spliceosomal complex)|go:"GO:0034715"(pICln-Sm protein complex)|go:"GO:0034719"(SMN-Sm protein complex)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071004"(U2-type prespliceosome)|go:"GO:0071011"(precatalytic spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0097526"(spliceosomal tri-snRNP complex)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR027141|interpro:IPR034099|rcsb pdb:3JCM|rcsb pdb:5GAM|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GM6|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:5NRL|rcsb pdb:5WSG|rcsb pdb:5Y88|dip:DIP-715N|mint:P43321	-	crc64:DFAF7E3B7168D944	crc64:BB02A56C5AD70CF2	figure legend:Extended Data Fig 1a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/25	2021/01/05	rogid:2bNoVkou3QatkNCtPIiSdvPdgEo559292	rogid:ueJ4D76t8ilvz/p9qMzIGiCzqWk559292	rigid:icMPk+gSwfNCxH1Agk9cl1QN5wQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P32639	uniprotkb:P36048	intact:EBI-861|uniprotkb:D3DM80|ensemblfungi:YER172C	intact:EBI-243|uniprotkb:D6VX27|ensemblfungi:YKL173W	psi-mi:brr2_yeast(display_long)|uniprotkb:BRR2(gene name)|psi-mi:BRR2(display_short)|uniprotkb:RSS1(gene name synonym)|uniprotkb:SNU246(gene name synonym)|uniprotkb:YER172C(locus name)|uniprotkb:SYGP-ORF66(orf name)|uniprotkb:Protein Snu246(gene name synonym)	psi-mi:sn114_yeast(display_long)|uniprotkb:GIN10(gene name synonym)|uniprotkb:YKL173W(locus name)|uniprotkb:YKL637(orf name)|uniprotkb:SNU114(gene name)|psi-mi:SNU114(display_short)|uniprotkb:Growth inhibitory protein 10(gene name synonym)|uniprotkb:114 kDa U5 small nuclear ribonucleoprotein component(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Galej et al. (2016)	imex:IM-28615|pubmed:27459055	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26571789|imex:IM-28615-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011099.1|sgd:S000000974|dip:DIP-850N|mint:P32639|ensemblfungi:YER172C(gene)|ensemblfungi:YER172C_mRNA(transcript)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|rcsb pdb:3HIB|rcsb pdb:3IM1|rcsb pdb:3IM2|rcsb pdb:3JCM|rcsb pdb:4BGD|rcsb pdb:5DCA|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GAP|rcsb pdb:5GM6|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5M52|rcsb pdb:5M5P|rcsb pdb:5NRL|rcsb pdb:5ZWM|rcsb pdb:5ZWO|rcsb pdb:7B9V	refseq:NP_012748.1|sgd:S000001656|mint:P36048|dip:DIP-759N|ensemblfungi:YKL173W(gene)|ensemblfungi:YKL173W_mRNA(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000349"(generation of catalytic spliceosome for first transesterification step)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005682"(U5 snRNP)|go:"GO:0030623"(U5 snRNA binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000640(Translation elongation factor EFG/EF2, C-terminal)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR005517(Translation elongation factor EFG/EF2, domain IV)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR020568|interpro:IPR027417|interpro:IPR031950|interpro:IPR035647|interpro:IPR035655|interpro:IPR044121|rcsb pdb:3JCM|rcsb pdb:5GAM|rcsb pdb:5GAN|rcsb pdb:5GM6|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:5NRL|rcsb pdb:5WSG|rcsb pdb:5Y88|rcsb pdb:5YLZ|rcsb pdb:5ZWM|rcsb pdb:5ZWO|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q|rcsb pdb:6TEO	-	crc64:DFAF7E3B7168D944	crc64:5CE30CEFF154D013	figure legend:Extended Data Fig 1a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/25	2021/01/05	rogid:2bNoVkou3QatkNCtPIiSdvPdgEo559292	rogid:eHDUPadk87+Qb525xpL1tMWb3S4559292	rigid:icMPk+gSwfNCxH1Agk9cl1QN5wQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P32639	uniprotkb:Q06091	intact:EBI-861|uniprotkb:D3DM80|ensemblfungi:YER172C	intact:EBI-818|uniprotkb:D6W499|ensemblfungi:YPR101W	psi-mi:brr2_yeast(display_long)|uniprotkb:BRR2(gene name)|psi-mi:BRR2(display_short)|uniprotkb:RSS1(gene name synonym)|uniprotkb:SNU246(gene name synonym)|uniprotkb:YER172C(locus name)|uniprotkb:SYGP-ORF66(orf name)|uniprotkb:Protein Snu246(gene name synonym)	psi-mi:sn309_yeast(display_long)|uniprotkb:YPR101W(locus name)|uniprotkb:SNT309(gene name)|psi-mi:SNT309(display_short)|uniprotkb:NTC25(gene name synonym)|uniprotkb:Synergistic to PRP19 mutation protein 309(gene name synonym)|uniprotkb:PRP19-associated complex protein 25(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Galej et al. (2016)	imex:IM-28615|pubmed:27459055	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26571789|imex:IM-28615-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011099.1|sgd:S000000974|dip:DIP-850N|mint:P32639|ensemblfungi:YER172C(gene)|ensemblfungi:YER172C_mRNA(transcript)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|rcsb pdb:3HIB|rcsb pdb:3IM1|rcsb pdb:3IM2|rcsb pdb:3JCM|rcsb pdb:4BGD|rcsb pdb:5DCA|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GAP|rcsb pdb:5GM6|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5M52|rcsb pdb:5M5P|rcsb pdb:5NRL|rcsb pdb:5ZWM|rcsb pdb:5ZWO|rcsb pdb:7B9V	sgd:S000006305|refseq:NP_015426.1|dip:DIP-2864N|mint:Q06091|ensemblfungi:YPR101W(gene)|ensemblfungi:YPR101W_mRNA(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000974"(Prp19 complex)|go:"GO:0071006"(U2-type catalytic step 1 spliceosome)|rcsb pdb:5GM6|rcsb pdb:5GMK|rcsb pdb:5LJ5|rcsb pdb:5MQ0|rcsb pdb:5WSG|rcsb pdb:5Y88|rcsb pdb:5YLZ|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q	-	crc64:DFAF7E3B7168D944	crc64:B781CA65BC9A1918	figure legend:Extended Data Fig 1a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/25	2021/01/05	rogid:2bNoVkou3QatkNCtPIiSdvPdgEo559292	rogid:ELyyYlQDmNRzWKQx/63xvHuAG8M559292	rigid:icMPk+gSwfNCxH1Agk9cl1QN5wQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P32639	uniprotkb:Q04048	intact:EBI-861|uniprotkb:D3DM80|ensemblfungi:YER172C	intact:EBI-540|uniprotkb:D6VT47|ensemblfungi:YDR416W	psi-mi:brr2_yeast(display_long)|uniprotkb:BRR2(gene name)|psi-mi:BRR2(display_short)|uniprotkb:RSS1(gene name synonym)|uniprotkb:SNU246(gene name synonym)|uniprotkb:YER172C(locus name)|uniprotkb:SYGP-ORF66(orf name)|uniprotkb:Protein Snu246(gene name synonym)	psi-mi:syf1_yeast(display_long)|uniprotkb:SYF1(gene name)|psi-mi:SYF1(display_short)|uniprotkb:NTC90(gene name synonym)|uniprotkb:Synthetic lethal with CDC40 protein 1(gene name synonym)|uniprotkb:PRP19-associated complex protein 90(gene name synonym)|uniprotkb:YDR416W(locus name)	psi-mi:"MI:0071"(molecular sieving)	Galej et al. (2016)	imex:IM-28615|pubmed:27459055	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26571789|imex:IM-28615-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011099.1|sgd:S000000974|dip:DIP-850N|mint:P32639|ensemblfungi:YER172C(gene)|ensemblfungi:YER172C_mRNA(transcript)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|rcsb pdb:3HIB|rcsb pdb:3IM1|rcsb pdb:3IM2|rcsb pdb:3JCM|rcsb pdb:4BGD|rcsb pdb:5DCA|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GAP|rcsb pdb:5GM6|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5M52|rcsb pdb:5M5P|rcsb pdb:5NRL|rcsb pdb:5ZWM|rcsb pdb:5ZWO|rcsb pdb:7B9V	refseq:NP_010704.1|sgd:S000002824|rcsb pdb:5YLZ|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q|reactome:R-SCE-6781823|reactome:R-SCE-6782135|reactome:R-SCE-6782210|rcsb pdb:5Y88|ensemblfungi:YDR416W(gene)|ensemblfungi:YDR416W_mRNA(transcript)|go:"GO:0000349"(generation of catalytic spliceosome for first transesterification step)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000974"(Prp19 complex)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0071004"(U2-type prespliceosome)|go:"GO:0071006"(U2-type catalytic step 1 spliceosome)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071008"(U2-type post-mRNA release spliceosomal complex)|go:"GO:0071014"(post-mRNA release spliceosomal complex)|interpro:IPR003107(RNA-processing protein, HAT helix)|interpro:IPR011990(Tetratricopeptide-like helical)|rcsb pdb:5GM6|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:5WSG|dip:DIP-1681N|mint:Q04048	-	crc64:DFAF7E3B7168D944	crc64:ED4368A624A40E7C	figure legend:Extended Data Fig 1a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/25	2021/01/05	rogid:2bNoVkou3QatkNCtPIiSdvPdgEo559292	rogid:+1TwiqsQv1IcWxuoIWcJGtTCUFU559292	rigid:icMPk+gSwfNCxH1Agk9cl1QN5wQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P32639	uniprotkb:P28320	intact:EBI-861|uniprotkb:D3DM80|ensemblfungi:YER172C	intact:EBI-26795|uniprotkb:D6VXJ3|ensemblfungi:YKL095W	psi-mi:brr2_yeast(display_long)|uniprotkb:BRR2(gene name)|psi-mi:BRR2(display_short)|uniprotkb:RSS1(gene name synonym)|uniprotkb:SNU246(gene name synonym)|uniprotkb:YER172C(locus name)|uniprotkb:SYGP-ORF66(orf name)|uniprotkb:Protein Snu246(gene name synonym)	psi-mi:yju2_yeast(display_long)|uniprotkb:YKL095W(locus name)|uniprotkb:YKL442(orf name)|uniprotkb:YJU2(gene name)|psi-mi:YJU2(display_short)|uniprotkb:CWC16(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Galej et al. (2016)	imex:IM-28615|pubmed:27459055	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-26571789|imex:IM-28615-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011099.1|sgd:S000000974|dip:DIP-850N|mint:P32639|ensemblfungi:YER172C(gene)|ensemblfungi:YER172C_mRNA(transcript)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|rcsb pdb:3HIB|rcsb pdb:3IM1|rcsb pdb:3IM2|rcsb pdb:3JCM|rcsb pdb:4BGD|rcsb pdb:5DCA|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GAP|rcsb pdb:5GM6|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5M52|rcsb pdb:5M5P|rcsb pdb:5NRL|rcsb pdb:5ZWM|rcsb pdb:5ZWO|rcsb pdb:7B9V	refseq:NP_012828.1|sgd:S000001578|mint:P28320|dip:DIP-1915N|ensemblfungi:YKL095W(gene)|ensemblfungi:YKL095W_mRNA(transcript)|go:"GO:0000349"(generation of catalytic spliceosome for first transesterification step)|go:"GO:0000350"(generation of catalytic spliceosome for second transesterification step)|go:"GO:0005634"(nucleus)|go:"GO:0008380"(RNA splicing)|go:"GO:0030620"(U2 snRNA binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0071006"(U2-type catalytic step 1 spliceosome)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|interpro:IPR007590(Protein of unknown function DUF572)|interpro:IPR043701|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5Y88|rcsb pdb:6EXN|rcsb pdb:6J6Q	-	crc64:DFAF7E3B7168D944	crc64:B57F3A173A2113FD	figure legend:Extended Data Fig 1a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/25	2021/01/05	rogid:2bNoVkou3QatkNCtPIiSdvPdgEo559292	rogid:RB1yjFkujiRVEYwnEtk3x0Beo88559292	rigid:icMPk+gSwfNCxH1Agk9cl1QN5wQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)