#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B chebi:"CHEBI:59524" uniprotkb:P11226-PRO_0000017401 intact:EBI-26878120 intact:EBI-25427940 psi-mi:lipoarabinomannan(display_short)|psi-mi:"CHEBI:59524"(display_long)|intact:LAMs(synonym)|intact:lipoarabinomannans(synonym)|intact:LAM(synonym) psi-mi:p11226-pro_0000017401(display_long)|uniprotkb:Collectin-1(gene name synonym)|uniprotkb:MBP1(gene name synonym)|uniprotkb:Mannan-binding protein(gene name synonym)|uniprotkb:Mannose-binding lectin(gene name synonym)|uniprotkb:MBL2(gene name)|psi-mi:MBL2(display_short)|uniprotkb:COLEC1(gene name synonym)|uniprotkb:MBL(gene name synonym) psi-mi:"MI:0892"(solid phase assay) Świerzko et al. (2016) imex:IM-28818|pubmed:27141819 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26878118|imex:IM-28818-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - intact:EBI-5325353(chain-parent) - - chain-seq-start:21|chain-seq-end:248 figure legend:2A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/12/18 2021/04/19 - rogid:niwSuVS9f0s8HBqDB7SSsrtneS89606 - false carbohydrate chemical modification:?-? - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P11226-PRO_0000017401 uniprotkb:P9WQP3-PRO_0000000214 intact:EBI-25427940 intact:EBI-26878164 psi-mi:p11226-pro_0000017401(display_long)|uniprotkb:Collectin-1(gene name synonym)|uniprotkb:MBP1(gene name synonym)|uniprotkb:Mannan-binding protein(gene name synonym)|uniprotkb:Mannose-binding lectin(gene name synonym)|uniprotkb:MBL2(gene name)|psi-mi:MBL2(display_short)|uniprotkb:COLEC1(gene name synonym)|uniprotkb:MBL(gene name synonym) psi-mi:p9wqp3-pro_0000000214(display_long)|uniprotkb:fbpA(gene name)|psi-mi:fbpA(display_short)|uniprotkb:mpt44(gene name synonym)|uniprotkb:MTV026.09c(orf name)|uniprotkb:Rv3804c(locus name)|uniprotkb:"Acyl-CoA:diacylglycerol acyltransferase"(gene name synonym)|uniprotkb:Antigen 85 complex A(gene name synonym)|uniprotkb:Fibronectin-binding protein A(gene name synonym) psi-mi:"MI:0892"(solid phase assay) Świerzko et al. (2016) imex:IM-28818|pubmed:27141819 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:83332(myctu)|taxid:83332("Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26878129|imex:IM-28818-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-5325353(chain-parent) intact:EBI-26878135(chain-parent) - chain-seq-start:21|chain-seq-end:248 chain-seq-start:44|chain-seq-end:338 figure legend:2B, number 1|comment:"weak interaction (Ag85A with MBL)."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/12/18 2021/03/18 rogid:niwSuVS9f0s8HBqDB7SSsrtneS89606 rogid:Mzt8Fm4pOKzsx7P1aOdMO8CWRag83332 rigid:wJVqgTVfNuw8JmKxQFu/En49ICw false - his tag:c-c - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:O00602-PRO_0000009136 uniprotkb:P9WQP3-PRO_0000000214 intact:EBI-11784425 intact:EBI-26878164 psi-mi:o00602-pro_0000009136(display_long)|uniprotkb:FCN1(gene name)|psi-mi:FCN1(display_short)|uniprotkb:FCNM(gene name synonym)|uniprotkb:Collagen/fibrinogen domain-containing protein 1(gene name synonym)|uniprotkb:Ficolin-A(gene name synonym)|uniprotkb:Ficolin-alpha(gene name synonym)|uniprotkb:M-ficolin(gene name synonym) psi-mi:p9wqp3-pro_0000000214(display_long)|uniprotkb:fbpA(gene name)|psi-mi:fbpA(display_short)|uniprotkb:mpt44(gene name synonym)|uniprotkb:MTV026.09c(orf name)|uniprotkb:Rv3804c(locus name)|uniprotkb:"Acyl-CoA:diacylglycerol acyltransferase"(gene name synonym)|uniprotkb:Antigen 85 complex A(gene name synonym)|uniprotkb:Fibronectin-binding protein A(gene name synonym) psi-mi:"MI:0892"(solid phase assay) Świerzko et al. (2016) imex:IM-28818|pubmed:27141819 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:83332(myctu)|taxid:83332("Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26878175|imex:IM-28818-21 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-5282479(chain-parent) intact:EBI-26878135(chain-parent) - chain-seq-start:30|chain-seq-end:326 chain-seq-start:44|chain-seq-end:338 figure legend:2B, number 2|comment:Ag85A with Ficolin 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/12/18 2021/03/18 rogid:lTaQw2TU6drH0Rwv4iOyx5zQXZo9606 rogid:Mzt8Fm4pOKzsx7P1aOdMO8CWRag83332 rigid:rj5ZQsvw+PtYL6PKj0qW3fLx/1c false his tag:c-c his tag:c-c - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:Q15485 uniprotkb:P9WQP3-PRO_0000000214 intact:EBI-7468784|uniprotkb:A6NFG7|uniprotkb:Q9UC57|uniprotkb:Q6IS69|intact:MINT-5223224|uniprotkb:Q7M4P4|uniprotkb:A8K478|ensembl:ENSP00000291744 intact:EBI-26878164 psi-mi:fcn2_human(display_long)|uniprotkb:FCN2(gene name)|psi-mi:FCN2(display_short)|uniprotkb:FCNL(gene name synonym)|uniprotkb:Ficolin-B(gene name synonym)|uniprotkb:Ficolin-beta(gene name synonym)|uniprotkb:L-ficolin(gene name synonym)|uniprotkb:Collagen/fibrinogen domain-containing protein 2(gene name synonym)|uniprotkb:Serum lectin p35(gene name synonym)|uniprotkb:37 kDa elastin-binding protein(gene name synonym)|uniprotkb:EBP-37(gene name synonym)|uniprotkb:Hucolin(gene name synonym) psi-mi:p9wqp3-pro_0000000214(display_long)|uniprotkb:fbpA(gene name)|psi-mi:fbpA(display_short)|uniprotkb:mpt44(gene name synonym)|uniprotkb:MTV026.09c(orf name)|uniprotkb:Rv3804c(locus name)|uniprotkb:"Acyl-CoA:diacylglycerol acyltransferase"(gene name synonym)|uniprotkb:Antigen 85 complex A(gene name synonym)|uniprotkb:Fibronectin-binding protein A(gene name synonym) psi-mi:"MI:0892"(solid phase assay) Świerzko et al. (2016) imex:IM-28818|pubmed:27141819 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:83332(myctu)|taxid:83332("Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26878185|imex:IM-28818-41 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004099.2|refseq:NP_056652.1|ensembl:ENSG00000160339(gene)|ensembl:ENST00000291744(transcript)|go:"GO:0001867"(complement activation, lectin pathway)|go:"GO:0003823"(antigen binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0008228"(opsonization)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0043654"(recognition of apoptotic cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0097367"(carbohydrate derivative binding)|go:"GO:2001065"(mannan binding)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|interpro:IPR036056|mint:Q15485|rcsb pdb:2J0G|rcsb pdb:2J0H|rcsb pdb:2J0Y|rcsb pdb:2J1G|rcsb pdb:2J2P|rcsb pdb:2J3F|rcsb pdb:2J3G|rcsb pdb:2J3O|rcsb pdb:2J3U|rcsb pdb:2J61|rcsb pdb:4NYT|rcsb pdb:4R9J|rcsb pdb:4R9T|reactome:R-HSA-166662|reactome:R-HSA-166663|reactome:R-HSA-2855086 intact:EBI-26878135(chain-parent) - comment:mint|function:Calcium-dependent and GlcNAc-binding lectin. Enhanced phagocytosis of S.typhimurium by neutrophils, suggesting an opsonic effect via the collagen region chain-seq-start:44|chain-seq-end:338 figure legend:2B, number 3|comment:Ag85A with Ficolin 2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/12/18 2021/03/18 rogid:j6vRtYG3I6cn0c2TId/73bE/1To9606 rogid:Mzt8Fm4pOKzsx7P1aOdMO8CWRag83332 rigid:ENcDabKR7UQ410z3ScpNmxeKu9c false his tag:c-c|sufficient binding region:26-313 his tag:c-c - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:O75636 uniprotkb:P9WQP3-PRO_0000000214 intact:EBI-11786958|uniprotkb:Q6IBJ5|uniprotkb:Q8WW86|ensembl:ENSP00000270879 intact:EBI-26878164 psi-mi:fcn3_human(display_long)|uniprotkb:FCN3(gene name)|psi-mi:FCN3(display_short)|uniprotkb:FCNH(gene name synonym)|uniprotkb:HAKA1(gene name synonym)|uniprotkb:Collagen/fibrinogen domain-containing lectin 3 p35(gene name synonym)|uniprotkb:Collagen/fibrinogen domain-containing protein 3(gene name synonym)|uniprotkb:Hakata antigen(gene name synonym) psi-mi:p9wqp3-pro_0000000214(display_long)|uniprotkb:fbpA(gene name)|psi-mi:fbpA(display_short)|uniprotkb:mpt44(gene name synonym)|uniprotkb:MTV026.09c(orf name)|uniprotkb:Rv3804c(locus name)|uniprotkb:"Acyl-CoA:diacylglycerol acyltransferase"(gene name synonym)|uniprotkb:Antigen 85 complex A(gene name synonym)|uniprotkb:Fibronectin-binding protein A(gene name synonym) psi-mi:"MI:0892"(solid phase assay) Świerzko et al. (2016) imex:IM-28818|pubmed:27141819 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:83332(myctu)|taxid:83332("Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26878194|imex:IM-28818-43 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003656.2|refseq:NP_775628.1|ensembl:ENSG00000142748(gene)|ensembl:ENST00000270879(transcript)|go:"GO:0001867"(complement activation, lectin pathway)|go:"GO:0003823"(antigen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0006956"(complement activation)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0043654"(recognition of apoptotic cell)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0072562"(blood microparticle)|go:"GO:1902679"(negative regulation of RNA biosynthetic process)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|interpro:IPR036056|rcsb pdb:1LA5|rcsb pdb:2J5Z|rcsb pdb:2J60|rcsb pdb:2J64|reactome:R-HSA-166662|reactome:R-HSA-166663|reactome:R-HSA-2855086 intact:EBI-26878135(chain-parent) - - chain-seq-start:44|chain-seq-end:338 figure legend:2B, number 4|comment:Ag85A with Ficolin 3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/12/18 2021/03/18 rogid:Uqrs95TKW2LaGqmcRkU9cu3v2FA9606 rogid:Mzt8Fm4pOKzsx7P1aOdMO8CWRag83332 rigid:lrPubyhgmwqcTkoybAOObXthI5Y false his tag:c-c|sufficient binding region:22-299 his tag:c-c - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P11226-PRO_0000017401 uniprotkb:P9WQP1 intact:EBI-25427940 intact:EBI-26878221|uniprotkb:D6MJP5|uniprotkb:F2GHQ8|uniprotkb:P0C5B9|uniprotkb:P31952|uniprotkb:Q9RMI0 psi-mi:p11226-pro_0000017401(display_long)|uniprotkb:Collectin-1(gene name synonym)|uniprotkb:MBP1(gene name synonym)|uniprotkb:Mannan-binding protein(gene name synonym)|uniprotkb:Mannose-binding lectin(gene name synonym)|uniprotkb:MBL2(gene name)|psi-mi:MBL2(display_short)|uniprotkb:COLEC1(gene name synonym)|uniprotkb:MBL(gene name synonym) psi-mi:a85b_myctu(display_long)|uniprotkb:fbpB(gene name)|psi-mi:fbpB(display_short)|uniprotkb:30 kDa extracellular protein(gene name synonym)|uniprotkb:"Acyl-CoA:diacylglycerol acyltransferase"(gene name synonym)|uniprotkb:Antigen 85 complex B(gene name synonym)|uniprotkb:Extracellular alpha-antigen(gene name synonym)|uniprotkb:Fibronectin-binding protein B(gene name synonym)|uniprotkb:MTCY180.32(orf name)|uniprotkb:Rv1886c(locus name) psi-mi:"MI:0892"(solid phase assay) Świerzko et al. (2016) imex:IM-28818|pubmed:27141819 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:83332(myctu)|taxid:83332("Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26878214|imex:IM-28818-23 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-5325353(chain-parent) go:"GO:0001968"(fibronectin binding)|go:"GO:0004144"(diacylglycerol O-acyltransferase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005618"(cell wall)|go:"GO:0005886"(plasma membrane)|go:"GO:0010756"(positive regulation of plasminogen activation)|go:"GO:0016747"(acyltransferase activity, transferring groups other than amino-acyl groups)|go:"GO:0035375"(zymogen binding)|go:"GO:0040009"(regulation of growth rate)|go:"GO:0046677"(response to antibiotic)|go:"GO:0050348"(trehalose O-mycolyltransferase activity)|go:"GO:0052572"(response to host immune response)|go:"GO:0071769"(mycolate cell wall layer assembly)|refseq:NP_216402.1|refseq:WP_003409456.1|rcsb pdb:1F0N|rcsb pdb:1F0P|rcsb pdb:5TRZ|rcsb pdb:5TS1|interpro:IPR029058|interpro:IPR000801(Putative esterase) - chain-seq-start:21|chain-seq-end:248 - figure legend:2C, 3, number 1|comment:"weak interaction (Ag85B with MBL)."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/12/18 2021/03/18 rogid:niwSuVS9f0s8HBqDB7SSsrtneS89606 rogid:5szrASs87LZuw0JpQGKhPP+lcFU83332 rigid:a8BEIwdxTRqTc0e19FCPl24rpjk false - - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:O00602-PRO_0000009136 uniprotkb:P9WQP1 intact:EBI-11784425 intact:EBI-26878221|uniprotkb:D6MJP5|uniprotkb:F2GHQ8|uniprotkb:P0C5B9|uniprotkb:P31952|uniprotkb:Q9RMI0 psi-mi:o00602-pro_0000009136(display_long)|uniprotkb:FCN1(gene name)|psi-mi:FCN1(display_short)|uniprotkb:FCNM(gene name synonym)|uniprotkb:Collagen/fibrinogen domain-containing protein 1(gene name synonym)|uniprotkb:Ficolin-A(gene name synonym)|uniprotkb:Ficolin-alpha(gene name synonym)|uniprotkb:M-ficolin(gene name synonym) psi-mi:a85b_myctu(display_long)|uniprotkb:fbpB(gene name)|psi-mi:fbpB(display_short)|uniprotkb:30 kDa extracellular protein(gene name synonym)|uniprotkb:"Acyl-CoA:diacylglycerol acyltransferase"(gene name synonym)|uniprotkb:Antigen 85 complex B(gene name synonym)|uniprotkb:Extracellular alpha-antigen(gene name synonym)|uniprotkb:Fibronectin-binding protein B(gene name synonym)|uniprotkb:MTCY180.32(orf name)|uniprotkb:Rv1886c(locus name) psi-mi:"MI:0892"(solid phase assay) Świerzko et al. (2016) imex:IM-28818|pubmed:27141819 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:83332(myctu)|taxid:83332("Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26878254|imex:IM-28818-25 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-5282479(chain-parent) go:"GO:0001968"(fibronectin binding)|go:"GO:0004144"(diacylglycerol O-acyltransferase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005618"(cell wall)|go:"GO:0005886"(plasma membrane)|go:"GO:0010756"(positive regulation of plasminogen activation)|go:"GO:0016747"(acyltransferase activity, transferring groups other than amino-acyl groups)|go:"GO:0035375"(zymogen binding)|go:"GO:0040009"(regulation of growth rate)|go:"GO:0046677"(response to antibiotic)|go:"GO:0050348"(trehalose O-mycolyltransferase activity)|go:"GO:0052572"(response to host immune response)|go:"GO:0071769"(mycolate cell wall layer assembly)|refseq:NP_216402.1|refseq:WP_003409456.1|rcsb pdb:1F0N|rcsb pdb:1F0P|rcsb pdb:5TRZ|rcsb pdb:5TS1|interpro:IPR029058|interpro:IPR000801(Putative esterase) - chain-seq-start:30|chain-seq-end:326 - figure legend:2C, 3, number 2|comment:Ag85B with Ficolin 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/12/18 2021/03/18 rogid:lTaQw2TU6drH0Rwv4iOyx5zQXZo9606 rogid:5szrASs87LZuw0JpQGKhPP+lcFU83332 rigid:81w4NojGXWr7PfV3tKi5l+LD0sw false - - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:Q15485 uniprotkb:P9WQP1 intact:EBI-7468784|uniprotkb:A6NFG7|uniprotkb:Q9UC57|uniprotkb:Q6IS69|intact:MINT-5223224|uniprotkb:Q7M4P4|uniprotkb:A8K478|ensembl:ENSP00000291744 intact:EBI-26878221|uniprotkb:D6MJP5|uniprotkb:F2GHQ8|uniprotkb:P0C5B9|uniprotkb:P31952|uniprotkb:Q9RMI0 psi-mi:fcn2_human(display_long)|uniprotkb:FCN2(gene name)|psi-mi:FCN2(display_short)|uniprotkb:FCNL(gene name synonym)|uniprotkb:Ficolin-B(gene name synonym)|uniprotkb:Ficolin-beta(gene name synonym)|uniprotkb:L-ficolin(gene name synonym)|uniprotkb:Collagen/fibrinogen domain-containing protein 2(gene name synonym)|uniprotkb:Serum lectin p35(gene name synonym)|uniprotkb:37 kDa elastin-binding protein(gene name synonym)|uniprotkb:EBP-37(gene name synonym)|uniprotkb:Hucolin(gene name synonym) psi-mi:a85b_myctu(display_long)|uniprotkb:fbpB(gene name)|psi-mi:fbpB(display_short)|uniprotkb:30 kDa extracellular protein(gene name synonym)|uniprotkb:"Acyl-CoA:diacylglycerol acyltransferase"(gene name synonym)|uniprotkb:Antigen 85 complex B(gene name synonym)|uniprotkb:Extracellular alpha-antigen(gene name synonym)|uniprotkb:Fibronectin-binding protein B(gene name synonym)|uniprotkb:MTCY180.32(orf name)|uniprotkb:Rv1886c(locus name) psi-mi:"MI:0892"(solid phase assay) Świerzko et al. (2016) imex:IM-28818|pubmed:27141819 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:83332(myctu)|taxid:83332("Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26878260|imex:IM-28818-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004099.2|refseq:NP_056652.1|ensembl:ENSG00000160339(gene)|ensembl:ENST00000291744(transcript)|go:"GO:0001867"(complement activation, lectin pathway)|go:"GO:0003823"(antigen binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0008228"(opsonization)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0043654"(recognition of apoptotic cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0097367"(carbohydrate derivative binding)|go:"GO:2001065"(mannan binding)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|interpro:IPR036056|mint:Q15485|rcsb pdb:2J0G|rcsb pdb:2J0H|rcsb pdb:2J0Y|rcsb pdb:2J1G|rcsb pdb:2J2P|rcsb pdb:2J3F|rcsb pdb:2J3G|rcsb pdb:2J3O|rcsb pdb:2J3U|rcsb pdb:2J61|rcsb pdb:4NYT|rcsb pdb:4R9J|rcsb pdb:4R9T|reactome:R-HSA-166662|reactome:R-HSA-166663|reactome:R-HSA-2855086 go:"GO:0001968"(fibronectin binding)|go:"GO:0004144"(diacylglycerol O-acyltransferase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005618"(cell wall)|go:"GO:0005886"(plasma membrane)|go:"GO:0010756"(positive regulation of plasminogen activation)|go:"GO:0016747"(acyltransferase activity, transferring groups other than amino-acyl groups)|go:"GO:0035375"(zymogen binding)|go:"GO:0040009"(regulation of growth rate)|go:"GO:0046677"(response to antibiotic)|go:"GO:0050348"(trehalose O-mycolyltransferase activity)|go:"GO:0052572"(response to host immune response)|go:"GO:0071769"(mycolate cell wall layer assembly)|refseq:NP_216402.1|refseq:WP_003409456.1|rcsb pdb:1F0N|rcsb pdb:1F0P|rcsb pdb:5TRZ|rcsb pdb:5TS1|interpro:IPR029058|interpro:IPR000801(Putative esterase) - comment:mint|function:Calcium-dependent and GlcNAc-binding lectin. Enhanced phagocytosis of S.typhimurium by neutrophils, suggesting an opsonic effect via the collagen region - figure legend:2C, 3, number 3|comment:Ag85B with Ficolin 2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/12/18 2021/03/18 rogid:j6vRtYG3I6cn0c2TId/73bE/1To9606 rogid:5szrASs87LZuw0JpQGKhPP+lcFU83332 rigid:8shUNR4yIHWvmZYzS5Ji2dKoCKc false - - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:O75636 uniprotkb:P9WQP1 intact:EBI-11786958|uniprotkb:Q6IBJ5|uniprotkb:Q8WW86|ensembl:ENSP00000270879 intact:EBI-26878221|uniprotkb:D6MJP5|uniprotkb:F2GHQ8|uniprotkb:P0C5B9|uniprotkb:P31952|uniprotkb:Q9RMI0 psi-mi:fcn3_human(display_long)|uniprotkb:FCN3(gene name)|psi-mi:FCN3(display_short)|uniprotkb:FCNH(gene name synonym)|uniprotkb:HAKA1(gene name synonym)|uniprotkb:Collagen/fibrinogen domain-containing lectin 3 p35(gene name synonym)|uniprotkb:Collagen/fibrinogen domain-containing protein 3(gene name synonym)|uniprotkb:Hakata antigen(gene name synonym) psi-mi:a85b_myctu(display_long)|uniprotkb:fbpB(gene name)|psi-mi:fbpB(display_short)|uniprotkb:30 kDa extracellular protein(gene name synonym)|uniprotkb:"Acyl-CoA:diacylglycerol acyltransferase"(gene name synonym)|uniprotkb:Antigen 85 complex B(gene name synonym)|uniprotkb:Extracellular alpha-antigen(gene name synonym)|uniprotkb:Fibronectin-binding protein B(gene name synonym)|uniprotkb:MTCY180.32(orf name)|uniprotkb:Rv1886c(locus name) psi-mi:"MI:0892"(solid phase assay) Świerzko et al. (2016) imex:IM-28818|pubmed:27141819 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:83332(myctu)|taxid:83332("Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26878265|imex:IM-28818-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003656.2|refseq:NP_775628.1|ensembl:ENSG00000142748(gene)|ensembl:ENST00000270879(transcript)|go:"GO:0001867"(complement activation, lectin pathway)|go:"GO:0003823"(antigen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0006956"(complement activation)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0043654"(recognition of apoptotic cell)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0072562"(blood microparticle)|go:"GO:1902679"(negative regulation of RNA biosynthetic process)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|interpro:IPR036056|rcsb pdb:1LA5|rcsb pdb:2J5Z|rcsb pdb:2J60|rcsb pdb:2J64|reactome:R-HSA-166662|reactome:R-HSA-166663|reactome:R-HSA-2855086 go:"GO:0001968"(fibronectin binding)|go:"GO:0004144"(diacylglycerol O-acyltransferase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005618"(cell wall)|go:"GO:0005886"(plasma membrane)|go:"GO:0010756"(positive regulation of plasminogen activation)|go:"GO:0016747"(acyltransferase activity, transferring groups other than amino-acyl groups)|go:"GO:0035375"(zymogen binding)|go:"GO:0040009"(regulation of growth rate)|go:"GO:0046677"(response to antibiotic)|go:"GO:0050348"(trehalose O-mycolyltransferase activity)|go:"GO:0052572"(response to host immune response)|go:"GO:0071769"(mycolate cell wall layer assembly)|refseq:NP_216402.1|refseq:WP_003409456.1|rcsb pdb:1F0N|rcsb pdb:1F0P|rcsb pdb:5TRZ|rcsb pdb:5TS1|interpro:IPR029058|interpro:IPR000801(Putative esterase) - - - figure legend:2C, 3, number 4|comment:Ag85B with Ficolin 3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/12/18 2021/03/18 rogid:Uqrs95TKW2LaGqmcRkU9cu3v2FA9606 rogid:5szrASs87LZuw0JpQGKhPP+lcFU83332 rigid:W5F83kFpK9pcJi1AvN5vHvkFkO4 false - - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) chebi:"CHEBI:4208" uniprotkb:P9WQP3-PRO_0000000214 intact:EBI-26878491 intact:EBI-26878164 psi-mi:d-mannopyranose(display_short)|psi-mi:"CHEBI:4208"(display_long)|intact:Carubinose(synonym)|intact:D-mannose(synonym)|intact:D-Mannose(synonym)|intact:mannopyranose(synonym)|intact:Seminose(synonym)|intact:D-mannopyranose(iupac name) psi-mi:p9wqp3-pro_0000000214(display_long)|uniprotkb:fbpA(gene name)|psi-mi:fbpA(display_short)|uniprotkb:mpt44(gene name synonym)|uniprotkb:MTV026.09c(orf name)|uniprotkb:Rv3804c(locus name)|uniprotkb:"Acyl-CoA:diacylglycerol acyltransferase"(gene name synonym)|uniprotkb:Antigen 85 complex A(gene name synonym)|uniprotkb:Fibronectin-binding protein A(gene name synonym) psi-mi:"MI:0892"(solid phase assay) Świerzko et al. (2016) imex:IM-28818|pubmed:27141819 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:83332(myctu)|taxid:83332("Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26878480|imex:IM-28818-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0586"(inhibitor) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - intact:EBI-26878135(chain-parent) - - chain-seq-start:44|chain-seq-end:338 figure legend:6|comment:"weak interaction (Ag85A with MBL)."|comment:"Approximately 60% of d‐mannose in solution occurs in the crystallized form of alpha‐d‐pyranose (CHEBI:28729), and the rest occurs in the form of beta‐d‐pyranose (CHEBI:28563)."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/12/18 2021/03/18 - rogid:Mzt8Fm4pOKzsx7P1aOdMO8CWRag83332 - false - his tag:c-c - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P9WQP3-PRO_0000000214 uniprotkb:P11226-PRO_0000017401 intact:EBI-26878164 intact:EBI-25427940 psi-mi:p9wqp3-pro_0000000214(display_long)|uniprotkb:fbpA(gene name)|psi-mi:fbpA(display_short)|uniprotkb:mpt44(gene name synonym)|uniprotkb:MTV026.09c(orf name)|uniprotkb:Rv3804c(locus name)|uniprotkb:"Acyl-CoA:diacylglycerol acyltransferase"(gene name synonym)|uniprotkb:Antigen 85 complex A(gene name synonym)|uniprotkb:Fibronectin-binding protein A(gene name synonym) psi-mi:p11226-pro_0000017401(display_long)|uniprotkb:Collectin-1(gene name synonym)|uniprotkb:MBP1(gene name synonym)|uniprotkb:Mannan-binding protein(gene name synonym)|uniprotkb:Mannose-binding lectin(gene name synonym)|uniprotkb:MBL2(gene name)|psi-mi:MBL2(display_short)|uniprotkb:COLEC1(gene name synonym)|uniprotkb:MBL(gene name synonym) psi-mi:"MI:0892"(solid phase assay) Świerzko et al. (2016) imex:IM-28818|pubmed:27141819 taxid:83332(myctu)|taxid:83332("Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26878480|imex:IM-28818-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-26878135(chain-parent) intact:EBI-5325353(chain-parent) - chain-seq-start:44|chain-seq-end:338 chain-seq-start:21|chain-seq-end:248 figure legend:6|comment:"weak interaction (Ag85A with MBL)."|comment:"Approximately 60% of d‐mannose in solution occurs in the crystallized form of alpha‐d‐pyranose (CHEBI:28729), and the rest occurs in the form of beta‐d‐pyranose (CHEBI:28563)."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/12/18 2021/03/18 rogid:Mzt8Fm4pOKzsx7P1aOdMO8CWRag83332 rogid:niwSuVS9f0s8HBqDB7SSsrtneS89606 - false his tag:c-c - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P9WQP3-PRO_0000000214 uniprotkb:P02769 intact:EBI-26878164 intact:EBI-2296927|uniprotkb:A5PJX3|uniprotkb:O02787|uniprotkb:P04277|uniprotkb:Q3SZR2 psi-mi:p9wqp3-pro_0000000214(display_long)|uniprotkb:fbpA(gene name)|psi-mi:fbpA(display_short)|uniprotkb:mpt44(gene name synonym)|uniprotkb:MTV026.09c(orf name)|uniprotkb:Rv3804c(locus name)|uniprotkb:"Acyl-CoA:diacylglycerol acyltransferase"(gene name synonym)|uniprotkb:Antigen 85 complex A(gene name synonym)|uniprotkb:Fibronectin-binding protein A(gene name synonym) psi-mi:albu_bovin(display_long)|uniprotkb:ALB(gene name)|psi-mi:ALB(display_short)|uniprotkb:BSA(gene name synonym) psi-mi:"MI:0892"(solid phase assay) Świerzko et al. (2016) imex:IM-28818|pubmed:27141819 taxid:83332(myctu)|taxid:83332("Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)") taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26878568|imex:IM-28818-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0586"(inhibitor) psi-mi:"MI:0496"(bait) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-26878135(chain-parent) rcsb pdb:4JK4|refseq:NP_851335.1|interpro:IPR000264(Serum albumin)|interpro:IPR020858|interpro:IPR020857|interpro:IPR014760(Serum albumin, N-terminal)|interpro:IPR021177|rcsb pdb:2L7U|rcsb pdb:3V03|rcsb pdb:4F5S|rcsb pdb:4OR0|rcsb pdb:6QS9|rcsb pdb:6RJV|go:"GO:0003677"(DNA binding)|go:"GO:0005504"(fatty acid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0015643"(toxic substance binding)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0051659"(maintenance of mitochondrion location)|go:"GO:1903981"(enterobactin binding) - chain-seq-start:44|chain-seq-end:338 - figure legend:6|comment:Ag85A with Ficolin 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/12/18 2021/03/18 rogid:Mzt8Fm4pOKzsx7P1aOdMO8CWRag83332 rogid:J8N23Xjyoe+UM5phxwqJtC2a1+M9913 rigid:CWz8fZSRy0y5ZajvKeTKWyVeyV8 false his tag:c-c monoacetylated residue:?-? - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P9WQP3-PRO_0000000214 uniprotkb:O00602-PRO_0000009136 intact:EBI-26878164 intact:EBI-11784425 psi-mi:p9wqp3-pro_0000000214(display_long)|uniprotkb:fbpA(gene name)|psi-mi:fbpA(display_short)|uniprotkb:mpt44(gene name synonym)|uniprotkb:MTV026.09c(orf name)|uniprotkb:Rv3804c(locus name)|uniprotkb:"Acyl-CoA:diacylglycerol acyltransferase"(gene name synonym)|uniprotkb:Antigen 85 complex A(gene name synonym)|uniprotkb:Fibronectin-binding protein A(gene name synonym) psi-mi:o00602-pro_0000009136(display_long)|uniprotkb:FCN1(gene name)|psi-mi:FCN1(display_short)|uniprotkb:FCNM(gene name synonym)|uniprotkb:Collagen/fibrinogen domain-containing protein 1(gene name synonym)|uniprotkb:Ficolin-A(gene name synonym)|uniprotkb:Ficolin-alpha(gene name synonym)|uniprotkb:M-ficolin(gene name synonym) psi-mi:"MI:0892"(solid phase assay) Świerzko et al. (2016) imex:IM-28818|pubmed:27141819 taxid:83332(myctu)|taxid:83332("Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26878568|imex:IM-28818-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-26878135(chain-parent) intact:EBI-5282479(chain-parent) - chain-seq-start:44|chain-seq-end:338 chain-seq-start:30|chain-seq-end:326 figure legend:6|comment:Ag85A with Ficolin 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/12/18 2021/03/18 rogid:Mzt8Fm4pOKzsx7P1aOdMO8CWRag83332 rogid:lTaQw2TU6drH0Rwv4iOyx5zQXZo9606 rigid:CWz8fZSRy0y5ZajvKeTKWyVeyV8 false his tag:c-c his tag:c-c - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P9WQP3-PRO_0000000214 uniprotkb:Q15485 intact:EBI-26878164 intact:EBI-7468784|uniprotkb:A6NFG7|uniprotkb:Q9UC57|uniprotkb:Q6IS69|intact:MINT-5223224|uniprotkb:Q7M4P4|uniprotkb:A8K478|ensembl:ENSP00000291744 psi-mi:p9wqp3-pro_0000000214(display_long)|uniprotkb:fbpA(gene name)|psi-mi:fbpA(display_short)|uniprotkb:mpt44(gene name synonym)|uniprotkb:MTV026.09c(orf name)|uniprotkb:Rv3804c(locus name)|uniprotkb:"Acyl-CoA:diacylglycerol acyltransferase"(gene name synonym)|uniprotkb:Antigen 85 complex A(gene name synonym)|uniprotkb:Fibronectin-binding protein A(gene name synonym) psi-mi:fcn2_human(display_long)|uniprotkb:FCN2(gene name)|psi-mi:FCN2(display_short)|uniprotkb:FCNL(gene name synonym)|uniprotkb:Ficolin-B(gene name synonym)|uniprotkb:Ficolin-beta(gene name synonym)|uniprotkb:L-ficolin(gene name synonym)|uniprotkb:Collagen/fibrinogen domain-containing protein 2(gene name synonym)|uniprotkb:Serum lectin p35(gene name synonym)|uniprotkb:37 kDa elastin-binding protein(gene name synonym)|uniprotkb:EBP-37(gene name synonym)|uniprotkb:Hucolin(gene name synonym) psi-mi:"MI:0892"(solid phase assay) Świerzko et al. (2016) imex:IM-28818|pubmed:27141819 taxid:83332(myctu)|taxid:83332("Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26878582|imex:IM-28818-33 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-26878135(chain-parent) refseq:NP_004099.2|refseq:NP_056652.1|ensembl:ENSG00000160339(gene)|ensembl:ENST00000291744(transcript)|go:"GO:0001867"(complement activation, lectin pathway)|go:"GO:0003823"(antigen binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0008228"(opsonization)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0043654"(recognition of apoptotic cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0097367"(carbohydrate derivative binding)|go:"GO:2001065"(mannan binding)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|interpro:IPR036056|mint:Q15485|rcsb pdb:2J0G|rcsb pdb:2J0H|rcsb pdb:2J0Y|rcsb pdb:2J1G|rcsb pdb:2J2P|rcsb pdb:2J3F|rcsb pdb:2J3G|rcsb pdb:2J3O|rcsb pdb:2J3U|rcsb pdb:2J61|rcsb pdb:4NYT|rcsb pdb:4R9J|rcsb pdb:4R9T|reactome:R-HSA-166662|reactome:R-HSA-166663|reactome:R-HSA-2855086 - chain-seq-start:44|chain-seq-end:338 comment:mint|function:Calcium-dependent and GlcNAc-binding lectin. Enhanced phagocytosis of S.typhimurium by neutrophils, suggesting an opsonic effect via the collagen region figure legend:6|comment:Ag85A with Ficolin 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/12/18 2021/03/18 rogid:Mzt8Fm4pOKzsx7P1aOdMO8CWRag83332 rogid:j6vRtYG3I6cn0c2TId/73bE/1To9606 rigid:X23JwOz6SBztap/QrVcZKtnERhA false his tag:c-c his tag:c-c - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P9WQP3-PRO_0000000214 uniprotkb:P02769 intact:EBI-26878164 intact:EBI-2296927|uniprotkb:A5PJX3|uniprotkb:O02787|uniprotkb:P04277|uniprotkb:Q3SZR2 psi-mi:p9wqp3-pro_0000000214(display_long)|uniprotkb:fbpA(gene name)|psi-mi:fbpA(display_short)|uniprotkb:mpt44(gene name synonym)|uniprotkb:MTV026.09c(orf name)|uniprotkb:Rv3804c(locus name)|uniprotkb:"Acyl-CoA:diacylglycerol acyltransferase"(gene name synonym)|uniprotkb:Antigen 85 complex A(gene name synonym)|uniprotkb:Fibronectin-binding protein A(gene name synonym) psi-mi:albu_bovin(display_long)|uniprotkb:ALB(gene name)|psi-mi:ALB(display_short)|uniprotkb:BSA(gene name synonym) psi-mi:"MI:0892"(solid phase assay) Świerzko et al. (2016) imex:IM-28818|pubmed:27141819 taxid:83332(myctu)|taxid:83332("Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)") taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26878582|imex:IM-28818-33 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0586"(inhibitor) psi-mi:"MI:0496"(bait) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-26878135(chain-parent) rcsb pdb:4JK4|refseq:NP_851335.1|interpro:IPR000264(Serum albumin)|interpro:IPR020858|interpro:IPR020857|interpro:IPR014760(Serum albumin, N-terminal)|interpro:IPR021177|rcsb pdb:2L7U|rcsb pdb:3V03|rcsb pdb:4F5S|rcsb pdb:4OR0|rcsb pdb:6QS9|rcsb pdb:6RJV|go:"GO:0003677"(DNA binding)|go:"GO:0005504"(fatty acid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0015643"(toxic substance binding)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0051659"(maintenance of mitochondrion location)|go:"GO:1903981"(enterobactin binding) - chain-seq-start:44|chain-seq-end:338 - figure legend:6|comment:Ag85A with Ficolin 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/12/18 2021/03/18 rogid:Mzt8Fm4pOKzsx7P1aOdMO8CWRag83332 rogid:J8N23Xjyoe+UM5phxwqJtC2a1+M9913 rigid:X23JwOz6SBztap/QrVcZKtnERhA false his tag:c-c monoacetylated residue:?-? - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) chebi:"CHEBI:167705" uniprotkb:P9WQP3-PRO_0000000214 intact:EBI-26878665 intact:EBI-26878164 psi-mi:pcm 1200 lps(display_short)|psi-mi:"CHEBI:167705"(display_long) psi-mi:p9wqp3-pro_0000000214(display_long)|uniprotkb:fbpA(gene name)|psi-mi:fbpA(display_short)|uniprotkb:mpt44(gene name synonym)|uniprotkb:MTV026.09c(orf name)|uniprotkb:Rv3804c(locus name)|uniprotkb:"Acyl-CoA:diacylglycerol acyltransferase"(gene name synonym)|uniprotkb:Antigen 85 complex A(gene name synonym)|uniprotkb:Fibronectin-binding protein A(gene name synonym) psi-mi:"MI:0892"(solid phase assay) Świerzko et al. (2016) imex:IM-28818|pubmed:27141819 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:83332(myctu)|taxid:83332("Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26878624|imex:IM-28818-51 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0586"(inhibitor) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - intact:EBI-26878135(chain-parent) - - chain-seq-start:44|chain-seq-end:338 figure legend:6|comment:Ag85A with Ficolin 3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/12/18 2021/03/18 - rogid:Mzt8Fm4pOKzsx7P1aOdMO8CWRag83332 - false - his tag:c-c - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P9WQP3-PRO_0000000214 uniprotkb:O75636 intact:EBI-26878164 intact:EBI-11786958|uniprotkb:Q6IBJ5|uniprotkb:Q8WW86|ensembl:ENSP00000270879 psi-mi:p9wqp3-pro_0000000214(display_long)|uniprotkb:fbpA(gene name)|psi-mi:fbpA(display_short)|uniprotkb:mpt44(gene name synonym)|uniprotkb:MTV026.09c(orf name)|uniprotkb:Rv3804c(locus name)|uniprotkb:"Acyl-CoA:diacylglycerol acyltransferase"(gene name synonym)|uniprotkb:Antigen 85 complex A(gene name synonym)|uniprotkb:Fibronectin-binding protein A(gene name synonym) psi-mi:fcn3_human(display_long)|uniprotkb:FCN3(gene name)|psi-mi:FCN3(display_short)|uniprotkb:FCNH(gene name synonym)|uniprotkb:HAKA1(gene name synonym)|uniprotkb:Collagen/fibrinogen domain-containing lectin 3 p35(gene name synonym)|uniprotkb:Collagen/fibrinogen domain-containing protein 3(gene name synonym)|uniprotkb:Hakata antigen(gene name synonym) psi-mi:"MI:0892"(solid phase assay) Świerzko et al. (2016) imex:IM-28818|pubmed:27141819 taxid:83332(myctu)|taxid:83332("Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26878624|imex:IM-28818-51 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-26878135(chain-parent) refseq:NP_003656.2|refseq:NP_775628.1|ensembl:ENSG00000142748(gene)|ensembl:ENST00000270879(transcript)|go:"GO:0001867"(complement activation, lectin pathway)|go:"GO:0003823"(antigen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0006956"(complement activation)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0043654"(recognition of apoptotic cell)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0072562"(blood microparticle)|go:"GO:1902679"(negative regulation of RNA biosynthetic process)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|interpro:IPR036056|rcsb pdb:1LA5|rcsb pdb:2J5Z|rcsb pdb:2J60|rcsb pdb:2J64|reactome:R-HSA-166662|reactome:R-HSA-166663|reactome:R-HSA-2855086 - chain-seq-start:44|chain-seq-end:338 - figure legend:6|comment:Ag85A with Ficolin 3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/12/18 2021/03/18 rogid:Mzt8Fm4pOKzsx7P1aOdMO8CWRag83332 rogid:Uqrs95TKW2LaGqmcRkU9cu3v2FA9606 - false his tag:c-c his tag:c-c|sufficient binding region:22-299 - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P11226-PRO_0000017401 uniprotkb:P02751 intact:EBI-25427940 intact:EBI-1220319|uniprotkb:Q7Z391|uniprotkb:O95609|uniprotkb:O95610|uniprotkb:Q14312|uniprotkb:Q14325|uniprotkb:Q14326|uniprotkb:Q17RV7|uniprotkb:Q585T2|uniprotkb:Q59EH1|uniprotkb:Q60FE4|uniprotkb:Q68DP8|uniprotkb:Q68DP9|uniprotkb:Q68DT4|uniprotkb:Q6LDP6|uniprotkb:Q6MZU5|uniprotkb:Q6N025|uniprotkb:Q6N0A6|uniprotkb:Q86T27|uniprotkb:Q8IVI8|uniprotkb:Q96KP7|uniprotkb:Q96KP8|uniprotkb:Q96KP9|uniprotkb:Q9H1B8|uniprotkb:Q9HAP3|uniprotkb:Q9UMK2|uniprotkb:Q6MZS0|uniprotkb:B7ZLF0|uniprotkb:E9PE77|uniprotkb:E9PG29|uniprotkb:Q564H7|uniprotkb:Q53S27|ensembl:ENSP00000346839 psi-mi:p11226-pro_0000017401(display_long)|uniprotkb:Collectin-1(gene name synonym)|uniprotkb:MBP1(gene name synonym)|uniprotkb:Mannan-binding protein(gene name synonym)|uniprotkb:Mannose-binding lectin(gene name synonym)|uniprotkb:MBL2(gene name)|psi-mi:MBL2(display_short)|uniprotkb:COLEC1(gene name synonym)|uniprotkb:MBL(gene name synonym) psi-mi:finc_human(display_long)|uniprotkb:FN1(gene name)|psi-mi:FN1(display_short)|uniprotkb:FN(gene name synonym)|uniprotkb:Cold-insoluble globulin(gene name synonym) psi-mi:"MI:0892"(solid phase assay) Świerzko et al. (2016) imex:IM-28818|pubmed:27141819 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26880646|imex:IM-28818-35 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-5325353(chain-parent) refseq:NP_002017.1|refseq:NP_473375.2|refseq:NP_997639.1|refseq:NP_997641.1|refseq:NP_997643.1|refseq:NP_997647.1|refseq:NP_001293058.1|refseq:NP_001293059.1|refseq:NP_001293060.1|refseq:NP_001293061.1|refseq:XP_005246463.1|dip:DIP-29547N|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009611"(response to wounding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0019899"(enzyme binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0033622"(integrin activation)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0051087"(chaperone binding)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|ensembl:ENSG00000115414(gene)|ensembl:ENST00000354785(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005577"(fibrinogen complex)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006953"(acute-phase response)|go:"GO:0007044"(cell-substrate junction assembly)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007161"(calcium-independent cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071635"(negative regulation of transforming growth factor beta production)|go:"GO:0072378"(blood coagulation, fibrin clot formation)|go:"GO:0072562"(blood microparticle)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1901166"(neural crest cell migration involved in autonomic nervous system development)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|interpro:IPR000083(Fibronectin, type I)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013806(Kringle-like fold)|interpro:IPR036116|interpro:IPR036943|mint:P02751|rcsb pdb:1E88|rcsb pdb:1E8B|rcsb pdb:1FBR|rcsb pdb:1FNA|rcsb pdb:1FNF|rcsb pdb:1FNH|rcsb pdb:1J8K|rcsb pdb:1O9A|rcsb pdb:1OWW|rcsb pdb:1Q38|rcsb pdb:1QGB|rcsb pdb:1QO6|rcsb pdb:1TTF|rcsb pdb:1TTG|rcsb pdb:2CG6|rcsb pdb:2CG7|rcsb pdb:2CK2|rcsb pdb:2CKU|rcsb pdb:2EC3|rcsb pdb:2FN2|rcsb pdb:2FNB|rcsb pdb:2GEE|rcsb pdb:2H41|rcsb pdb:2H45|rcsb pdb:2HA1|rcsb pdb:2MNU|rcsb pdb:2N1K|rcsb pdb:2OCF|rcsb pdb:2RKY|rcsb pdb:2RKZ|rcsb pdb:2RL0|rcsb pdb:3CAL|rcsb pdb:3EJH|rcsb pdb:3GXE|rcsb pdb:3M7P|rcsb pdb:3MQL|rcsb pdb:3R8Q|rcsb pdb:3T1W|rcsb pdb:3ZRZ|rcsb pdb:4GH7|rcsb pdb:4JE4|rcsb pdb:4JEG|rcsb pdb:4LXO|rcsb pdb:4MMX|rcsb pdb:4MMY|rcsb pdb:4MMZ|rcsb pdb:4PZ5|rcsb pdb:5DC0|rcsb pdb:5DC4|rcsb pdb:5DC9|rcsb pdb:5DFT|rcsb pdb:5J6Z|rcsb pdb:5J7C|rcsb pdb:5M0A|rcsb pdb:5N47|rcsb pdb:5N48|rcsb pdb:6HNF|rcsb pdb:6MFA|rcsb pdb:6MSV|rcsb pdb:6NAJ|rcsb pdb:6XAX|rcsb pdb:6XAY|rcsb pdb:7NWL|reactome:R-HSA-114608|reactome:R-HSA-1474228|reactome:R-HSA-1474244|reactome:R-HSA-1566977|reactome:R-HSA-202733|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-3000170|reactome:R-HSA-3000171|reactome:R-HSA-3000178|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-381426|reactome:R-HSA-5674135|reactome:R-HSA-6785807|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8874081|reactome:R-HSA-8957275|reactome:R-HSA-9649948|reactome:R-HSA-9656223 - chain-seq-start:21|chain-seq-end:248 - figure legend:8A, number 1|comment:"weak interaction (FN with MBL)."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/12/18 2021/03/18 rogid:niwSuVS9f0s8HBqDB7SSsrtneS89606 rogid:4arZu49X8b+dthqaX4DIh59V8h09606 rigid:gscAtYcw29zmrifc5Z/fQAWcWQU false - - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:O00602-PRO_0000009136 uniprotkb:P02751 intact:EBI-11784425 intact:EBI-1220319|uniprotkb:Q7Z391|uniprotkb:O95609|uniprotkb:O95610|uniprotkb:Q14312|uniprotkb:Q14325|uniprotkb:Q14326|uniprotkb:Q17RV7|uniprotkb:Q585T2|uniprotkb:Q59EH1|uniprotkb:Q60FE4|uniprotkb:Q68DP8|uniprotkb:Q68DP9|uniprotkb:Q68DT4|uniprotkb:Q6LDP6|uniprotkb:Q6MZU5|uniprotkb:Q6N025|uniprotkb:Q6N0A6|uniprotkb:Q86T27|uniprotkb:Q8IVI8|uniprotkb:Q96KP7|uniprotkb:Q96KP8|uniprotkb:Q96KP9|uniprotkb:Q9H1B8|uniprotkb:Q9HAP3|uniprotkb:Q9UMK2|uniprotkb:Q6MZS0|uniprotkb:B7ZLF0|uniprotkb:E9PE77|uniprotkb:E9PG29|uniprotkb:Q564H7|uniprotkb:Q53S27|ensembl:ENSP00000346839 psi-mi:o00602-pro_0000009136(display_long)|uniprotkb:FCN1(gene name)|psi-mi:FCN1(display_short)|uniprotkb:FCNM(gene name synonym)|uniprotkb:Collagen/fibrinogen domain-containing protein 1(gene name synonym)|uniprotkb:Ficolin-A(gene name synonym)|uniprotkb:Ficolin-alpha(gene name synonym)|uniprotkb:M-ficolin(gene name synonym) psi-mi:finc_human(display_long)|uniprotkb:FN1(gene name)|psi-mi:FN1(display_short)|uniprotkb:FN(gene name synonym)|uniprotkb:Cold-insoluble globulin(gene name synonym) psi-mi:"MI:0892"(solid phase assay) Świerzko et al. (2016) imex:IM-28818|pubmed:27141819 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26880653|imex:IM-28818-37 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-5282479(chain-parent) refseq:NP_002017.1|refseq:NP_473375.2|refseq:NP_997639.1|refseq:NP_997641.1|refseq:NP_997643.1|refseq:NP_997647.1|refseq:NP_001293058.1|refseq:NP_001293059.1|refseq:NP_001293060.1|refseq:NP_001293061.1|refseq:XP_005246463.1|dip:DIP-29547N|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009611"(response to wounding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0019899"(enzyme binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0033622"(integrin activation)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0051087"(chaperone binding)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|ensembl:ENSG00000115414(gene)|ensembl:ENST00000354785(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005577"(fibrinogen complex)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006953"(acute-phase response)|go:"GO:0007044"(cell-substrate junction assembly)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007161"(calcium-independent cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071635"(negative regulation of transforming growth factor beta production)|go:"GO:0072378"(blood coagulation, fibrin clot formation)|go:"GO:0072562"(blood microparticle)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1901166"(neural crest cell migration involved in autonomic nervous system development)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|interpro:IPR000083(Fibronectin, type I)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013806(Kringle-like fold)|interpro:IPR036116|interpro:IPR036943|mint:P02751|rcsb pdb:1E88|rcsb pdb:1E8B|rcsb pdb:1FBR|rcsb pdb:1FNA|rcsb pdb:1FNF|rcsb pdb:1FNH|rcsb pdb:1J8K|rcsb pdb:1O9A|rcsb pdb:1OWW|rcsb pdb:1Q38|rcsb pdb:1QGB|rcsb pdb:1QO6|rcsb pdb:1TTF|rcsb pdb:1TTG|rcsb pdb:2CG6|rcsb pdb:2CG7|rcsb pdb:2CK2|rcsb pdb:2CKU|rcsb pdb:2EC3|rcsb pdb:2FN2|rcsb pdb:2FNB|rcsb pdb:2GEE|rcsb pdb:2H41|rcsb pdb:2H45|rcsb pdb:2HA1|rcsb pdb:2MNU|rcsb pdb:2N1K|rcsb pdb:2OCF|rcsb pdb:2RKY|rcsb pdb:2RKZ|rcsb pdb:2RL0|rcsb pdb:3CAL|rcsb pdb:3EJH|rcsb pdb:3GXE|rcsb pdb:3M7P|rcsb pdb:3MQL|rcsb pdb:3R8Q|rcsb pdb:3T1W|rcsb pdb:3ZRZ|rcsb pdb:4GH7|rcsb pdb:4JE4|rcsb pdb:4JEG|rcsb pdb:4LXO|rcsb pdb:4MMX|rcsb pdb:4MMY|rcsb pdb:4MMZ|rcsb pdb:4PZ5|rcsb pdb:5DC0|rcsb pdb:5DC4|rcsb pdb:5DC9|rcsb pdb:5DFT|rcsb pdb:5J6Z|rcsb pdb:5J7C|rcsb pdb:5M0A|rcsb pdb:5N47|rcsb pdb:5N48|rcsb pdb:6HNF|rcsb pdb:6MFA|rcsb pdb:6MSV|rcsb pdb:6NAJ|rcsb pdb:6XAX|rcsb pdb:6XAY|rcsb pdb:7NWL|reactome:R-HSA-114608|reactome:R-HSA-1474228|reactome:R-HSA-1474244|reactome:R-HSA-1566977|reactome:R-HSA-202733|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-3000170|reactome:R-HSA-3000171|reactome:R-HSA-3000178|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-381426|reactome:R-HSA-5674135|reactome:R-HSA-6785807|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8874081|reactome:R-HSA-8957275|reactome:R-HSA-9649948|reactome:R-HSA-9656223 - chain-seq-start:30|chain-seq-end:326 - figure legend:8A, number 2|comment:FN with Ficolin 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/12/18 2021/03/18 rogid:lTaQw2TU6drH0Rwv4iOyx5zQXZo9606 rogid:4arZu49X8b+dthqaX4DIh59V8h09606 rigid:+ADZ7GUG4kmqV0AzgVUwyKK4ccE false his tag:c-c - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:Q15485 uniprotkb:P02751 intact:EBI-7468784|uniprotkb:A6NFG7|uniprotkb:Q9UC57|uniprotkb:Q6IS69|intact:MINT-5223224|uniprotkb:Q7M4P4|uniprotkb:A8K478|ensembl:ENSP00000291744 intact:EBI-1220319|uniprotkb:Q7Z391|uniprotkb:O95609|uniprotkb:O95610|uniprotkb:Q14312|uniprotkb:Q14325|uniprotkb:Q14326|uniprotkb:Q17RV7|uniprotkb:Q585T2|uniprotkb:Q59EH1|uniprotkb:Q60FE4|uniprotkb:Q68DP8|uniprotkb:Q68DP9|uniprotkb:Q68DT4|uniprotkb:Q6LDP6|uniprotkb:Q6MZU5|uniprotkb:Q6N025|uniprotkb:Q6N0A6|uniprotkb:Q86T27|uniprotkb:Q8IVI8|uniprotkb:Q96KP7|uniprotkb:Q96KP8|uniprotkb:Q96KP9|uniprotkb:Q9H1B8|uniprotkb:Q9HAP3|uniprotkb:Q9UMK2|uniprotkb:Q6MZS0|uniprotkb:B7ZLF0|uniprotkb:E9PE77|uniprotkb:E9PG29|uniprotkb:Q564H7|uniprotkb:Q53S27|ensembl:ENSP00000346839 psi-mi:fcn2_human(display_long)|uniprotkb:FCN2(gene name)|psi-mi:FCN2(display_short)|uniprotkb:FCNL(gene name synonym)|uniprotkb:Ficolin-B(gene name synonym)|uniprotkb:Ficolin-beta(gene name synonym)|uniprotkb:L-ficolin(gene name synonym)|uniprotkb:Collagen/fibrinogen domain-containing protein 2(gene name synonym)|uniprotkb:Serum lectin p35(gene name synonym)|uniprotkb:37 kDa elastin-binding protein(gene name synonym)|uniprotkb:EBP-37(gene name synonym)|uniprotkb:Hucolin(gene name synonym) psi-mi:finc_human(display_long)|uniprotkb:FN1(gene name)|psi-mi:FN1(display_short)|uniprotkb:FN(gene name synonym)|uniprotkb:Cold-insoluble globulin(gene name synonym) psi-mi:"MI:0892"(solid phase assay) Świerzko et al. (2016) imex:IM-28818|pubmed:27141819 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26880687|imex:IM-28818-19 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004099.2|refseq:NP_056652.1|ensembl:ENSG00000160339(gene)|ensembl:ENST00000291744(transcript)|go:"GO:0001867"(complement activation, lectin pathway)|go:"GO:0003823"(antigen binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0008228"(opsonization)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0043654"(recognition of apoptotic cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0097367"(carbohydrate derivative binding)|go:"GO:2001065"(mannan binding)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|interpro:IPR036056|mint:Q15485|rcsb pdb:2J0G|rcsb pdb:2J0H|rcsb pdb:2J0Y|rcsb pdb:2J1G|rcsb pdb:2J2P|rcsb pdb:2J3F|rcsb pdb:2J3G|rcsb pdb:2J3O|rcsb pdb:2J3U|rcsb pdb:2J61|rcsb pdb:4NYT|rcsb pdb:4R9J|rcsb pdb:4R9T|reactome:R-HSA-166662|reactome:R-HSA-166663|reactome:R-HSA-2855086 refseq:NP_002017.1|refseq:NP_473375.2|refseq:NP_997639.1|refseq:NP_997641.1|refseq:NP_997643.1|refseq:NP_997647.1|refseq:NP_001293058.1|refseq:NP_001293059.1|refseq:NP_001293060.1|refseq:NP_001293061.1|refseq:XP_005246463.1|dip:DIP-29547N|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009611"(response to wounding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0019899"(enzyme binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0033622"(integrin activation)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0051087"(chaperone binding)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|ensembl:ENSG00000115414(gene)|ensembl:ENST00000354785(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005577"(fibrinogen complex)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006953"(acute-phase response)|go:"GO:0007044"(cell-substrate junction assembly)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007161"(calcium-independent cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071635"(negative regulation of transforming growth factor beta production)|go:"GO:0072378"(blood coagulation, fibrin clot formation)|go:"GO:0072562"(blood microparticle)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1901166"(neural crest cell migration involved in autonomic nervous system development)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|interpro:IPR000083(Fibronectin, type I)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013806(Kringle-like fold)|interpro:IPR036116|interpro:IPR036943|mint:P02751|rcsb pdb:1E88|rcsb pdb:1E8B|rcsb pdb:1FBR|rcsb pdb:1FNA|rcsb pdb:1FNF|rcsb pdb:1FNH|rcsb pdb:1J8K|rcsb pdb:1O9A|rcsb pdb:1OWW|rcsb pdb:1Q38|rcsb pdb:1QGB|rcsb pdb:1QO6|rcsb pdb:1TTF|rcsb pdb:1TTG|rcsb pdb:2CG6|rcsb pdb:2CG7|rcsb pdb:2CK2|rcsb pdb:2CKU|rcsb pdb:2EC3|rcsb pdb:2FN2|rcsb pdb:2FNB|rcsb pdb:2GEE|rcsb pdb:2H41|rcsb pdb:2H45|rcsb pdb:2HA1|rcsb pdb:2MNU|rcsb pdb:2N1K|rcsb pdb:2OCF|rcsb pdb:2RKY|rcsb pdb:2RKZ|rcsb pdb:2RL0|rcsb pdb:3CAL|rcsb pdb:3EJH|rcsb pdb:3GXE|rcsb pdb:3M7P|rcsb pdb:3MQL|rcsb pdb:3R8Q|rcsb pdb:3T1W|rcsb pdb:3ZRZ|rcsb pdb:4GH7|rcsb pdb:4JE4|rcsb pdb:4JEG|rcsb pdb:4LXO|rcsb pdb:4MMX|rcsb pdb:4MMY|rcsb pdb:4MMZ|rcsb pdb:4PZ5|rcsb pdb:5DC0|rcsb pdb:5DC4|rcsb pdb:5DC9|rcsb pdb:5DFT|rcsb pdb:5J6Z|rcsb pdb:5J7C|rcsb pdb:5M0A|rcsb pdb:5N47|rcsb pdb:5N48|rcsb pdb:6HNF|rcsb pdb:6MFA|rcsb pdb:6MSV|rcsb pdb:6NAJ|rcsb pdb:6XAX|rcsb pdb:6XAY|rcsb pdb:7NWL|reactome:R-HSA-114608|reactome:R-HSA-1474228|reactome:R-HSA-1474244|reactome:R-HSA-1566977|reactome:R-HSA-202733|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-3000170|reactome:R-HSA-3000171|reactome:R-HSA-3000178|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-381426|reactome:R-HSA-5674135|reactome:R-HSA-6785807|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8874081|reactome:R-HSA-8957275|reactome:R-HSA-9649948|reactome:R-HSA-9656223 - comment:mint|function:Calcium-dependent and GlcNAc-binding lectin. Enhanced phagocytosis of S.typhimurium by neutrophils, suggesting an opsonic effect via the collagen region - figure legend:8A, number 3|comment:FN with Ficolin 2|comment:weak interaction|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/12/18 2021/03/18 rogid:j6vRtYG3I6cn0c2TId/73bE/1To9606 rogid:4arZu49X8b+dthqaX4DIh59V8h09606 rigid:3zqQco/6fk6t9Q69mZ4bpHNV1tA false his tag:c-c|sufficient binding region:26-313 - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:O75636 uniprotkb:P02751 intact:EBI-11786958|uniprotkb:Q6IBJ5|uniprotkb:Q8WW86|ensembl:ENSP00000270879 intact:EBI-1220319|uniprotkb:Q7Z391|uniprotkb:O95609|uniprotkb:O95610|uniprotkb:Q14312|uniprotkb:Q14325|uniprotkb:Q14326|uniprotkb:Q17RV7|uniprotkb:Q585T2|uniprotkb:Q59EH1|uniprotkb:Q60FE4|uniprotkb:Q68DP8|uniprotkb:Q68DP9|uniprotkb:Q68DT4|uniprotkb:Q6LDP6|uniprotkb:Q6MZU5|uniprotkb:Q6N025|uniprotkb:Q6N0A6|uniprotkb:Q86T27|uniprotkb:Q8IVI8|uniprotkb:Q96KP7|uniprotkb:Q96KP8|uniprotkb:Q96KP9|uniprotkb:Q9H1B8|uniprotkb:Q9HAP3|uniprotkb:Q9UMK2|uniprotkb:Q6MZS0|uniprotkb:B7ZLF0|uniprotkb:E9PE77|uniprotkb:E9PG29|uniprotkb:Q564H7|uniprotkb:Q53S27|ensembl:ENSP00000346839 psi-mi:fcn3_human(display_long)|uniprotkb:FCN3(gene name)|psi-mi:FCN3(display_short)|uniprotkb:FCNH(gene name synonym)|uniprotkb:HAKA1(gene name synonym)|uniprotkb:Collagen/fibrinogen domain-containing lectin 3 p35(gene name synonym)|uniprotkb:Collagen/fibrinogen domain-containing protein 3(gene name synonym)|uniprotkb:Hakata antigen(gene name synonym) psi-mi:finc_human(display_long)|uniprotkb:FN1(gene name)|psi-mi:FN1(display_short)|uniprotkb:FN(gene name synonym)|uniprotkb:Cold-insoluble globulin(gene name synonym) psi-mi:"MI:0892"(solid phase assay) Świerzko et al. (2016) imex:IM-28818|pubmed:27141819 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26880699|imex:IM-28818-39 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003656.2|refseq:NP_775628.1|ensembl:ENSG00000142748(gene)|ensembl:ENST00000270879(transcript)|go:"GO:0001867"(complement activation, lectin pathway)|go:"GO:0003823"(antigen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0006956"(complement activation)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0043654"(recognition of apoptotic cell)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0072562"(blood microparticle)|go:"GO:1902679"(negative regulation of RNA biosynthetic process)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|interpro:IPR036056|rcsb pdb:1LA5|rcsb pdb:2J5Z|rcsb pdb:2J60|rcsb pdb:2J64|reactome:R-HSA-166662|reactome:R-HSA-166663|reactome:R-HSA-2855086 refseq:NP_002017.1|refseq:NP_473375.2|refseq:NP_997639.1|refseq:NP_997641.1|refseq:NP_997643.1|refseq:NP_997647.1|refseq:NP_001293058.1|refseq:NP_001293059.1|refseq:NP_001293060.1|refseq:NP_001293061.1|refseq:XP_005246463.1|dip:DIP-29547N|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009611"(response to wounding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0019899"(enzyme binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0033622"(integrin activation)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0051087"(chaperone binding)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|ensembl:ENSG00000115414(gene)|ensembl:ENST00000354785(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005577"(fibrinogen complex)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006953"(acute-phase response)|go:"GO:0007044"(cell-substrate junction assembly)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007161"(calcium-independent cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071635"(negative regulation of transforming growth factor beta production)|go:"GO:0072378"(blood coagulation, fibrin clot formation)|go:"GO:0072562"(blood microparticle)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1901166"(neural crest cell migration involved in autonomic nervous system development)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|interpro:IPR000083(Fibronectin, type I)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013806(Kringle-like fold)|interpro:IPR036116|interpro:IPR036943|mint:P02751|rcsb pdb:1E88|rcsb pdb:1E8B|rcsb pdb:1FBR|rcsb pdb:1FNA|rcsb pdb:1FNF|rcsb pdb:1FNH|rcsb pdb:1J8K|rcsb pdb:1O9A|rcsb pdb:1OWW|rcsb pdb:1Q38|rcsb pdb:1QGB|rcsb pdb:1QO6|rcsb pdb:1TTF|rcsb pdb:1TTG|rcsb pdb:2CG6|rcsb pdb:2CG7|rcsb pdb:2CK2|rcsb pdb:2CKU|rcsb pdb:2EC3|rcsb pdb:2FN2|rcsb pdb:2FNB|rcsb pdb:2GEE|rcsb pdb:2H41|rcsb pdb:2H45|rcsb pdb:2HA1|rcsb pdb:2MNU|rcsb pdb:2N1K|rcsb pdb:2OCF|rcsb pdb:2RKY|rcsb pdb:2RKZ|rcsb pdb:2RL0|rcsb pdb:3CAL|rcsb pdb:3EJH|rcsb pdb:3GXE|rcsb pdb:3M7P|rcsb pdb:3MQL|rcsb pdb:3R8Q|rcsb pdb:3T1W|rcsb pdb:3ZRZ|rcsb pdb:4GH7|rcsb pdb:4JE4|rcsb pdb:4JEG|rcsb pdb:4LXO|rcsb pdb:4MMX|rcsb pdb:4MMY|rcsb pdb:4MMZ|rcsb pdb:4PZ5|rcsb pdb:5DC0|rcsb pdb:5DC4|rcsb pdb:5DC9|rcsb pdb:5DFT|rcsb pdb:5J6Z|rcsb pdb:5J7C|rcsb pdb:5M0A|rcsb pdb:5N47|rcsb pdb:5N48|rcsb pdb:6HNF|rcsb pdb:6MFA|rcsb pdb:6MSV|rcsb pdb:6NAJ|rcsb pdb:6XAX|rcsb pdb:6XAY|rcsb pdb:7NWL|reactome:R-HSA-114608|reactome:R-HSA-1474228|reactome:R-HSA-1474244|reactome:R-HSA-1566977|reactome:R-HSA-202733|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-3000170|reactome:R-HSA-3000171|reactome:R-HSA-3000178|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-381426|reactome:R-HSA-5674135|reactome:R-HSA-6785807|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8874081|reactome:R-HSA-8957275|reactome:R-HSA-9649948|reactome:R-HSA-9656223 - - - figure legend:8A, number 4|comment:FN with Ficolin 3;a strong interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/12/18 2021/03/18 rogid:Uqrs95TKW2LaGqmcRkU9cu3v2FA9606 rogid:4arZu49X8b+dthqaX4DIh59V8h09606 rigid:Vbc3JFppbXRDpkfuV/kjcerFAEU false his tag:c-c|sufficient binding region:22-299 - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P02751 uniprotkb:O75636 intact:EBI-1220319|uniprotkb:Q7Z391|uniprotkb:O95609|uniprotkb:O95610|uniprotkb:Q14312|uniprotkb:Q14325|uniprotkb:Q14326|uniprotkb:Q17RV7|uniprotkb:Q585T2|uniprotkb:Q59EH1|uniprotkb:Q60FE4|uniprotkb:Q68DP8|uniprotkb:Q68DP9|uniprotkb:Q68DT4|uniprotkb:Q6LDP6|uniprotkb:Q6MZU5|uniprotkb:Q6N025|uniprotkb:Q6N0A6|uniprotkb:Q86T27|uniprotkb:Q8IVI8|uniprotkb:Q96KP7|uniprotkb:Q96KP8|uniprotkb:Q96KP9|uniprotkb:Q9H1B8|uniprotkb:Q9HAP3|uniprotkb:Q9UMK2|uniprotkb:Q6MZS0|uniprotkb:B7ZLF0|uniprotkb:E9PE77|uniprotkb:E9PG29|uniprotkb:Q564H7|uniprotkb:Q53S27|ensembl:ENSP00000346839 intact:EBI-11786958|uniprotkb:Q6IBJ5|uniprotkb:Q8WW86|ensembl:ENSP00000270879 psi-mi:finc_human(display_long)|uniprotkb:FN1(gene name)|psi-mi:FN1(display_short)|uniprotkb:FN(gene name synonym)|uniprotkb:Cold-insoluble globulin(gene name synonym) psi-mi:fcn3_human(display_long)|uniprotkb:FCN3(gene name)|psi-mi:FCN3(display_short)|uniprotkb:FCNH(gene name synonym)|uniprotkb:HAKA1(gene name synonym)|uniprotkb:Collagen/fibrinogen domain-containing lectin 3 p35(gene name synonym)|uniprotkb:Collagen/fibrinogen domain-containing protein 3(gene name synonym)|uniprotkb:Hakata antigen(gene name synonym) psi-mi:"MI:0892"(solid phase assay) Świerzko et al. (2016) imex:IM-28818|pubmed:27141819 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-26880710|imex:IM-28818-53 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0941"(competitor) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002017.1|refseq:NP_473375.2|refseq:NP_997639.1|refseq:NP_997641.1|refseq:NP_997643.1|refseq:NP_997647.1|refseq:NP_001293058.1|refseq:NP_001293059.1|refseq:NP_001293060.1|refseq:NP_001293061.1|refseq:XP_005246463.1|dip:DIP-29547N|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009611"(response to wounding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0019899"(enzyme binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0033622"(integrin activation)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0051087"(chaperone binding)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|ensembl:ENSG00000115414(gene)|ensembl:ENST00000354785(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005577"(fibrinogen complex)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006953"(acute-phase response)|go:"GO:0007044"(cell-substrate junction assembly)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007161"(calcium-independent cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071635"(negative regulation of transforming growth factor beta production)|go:"GO:0072378"(blood coagulation, fibrin clot formation)|go:"GO:0072562"(blood microparticle)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1901166"(neural crest cell migration involved in autonomic nervous system development)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|interpro:IPR000083(Fibronectin, type I)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013806(Kringle-like fold)|interpro:IPR036116|interpro:IPR036943|mint:P02751|rcsb pdb:1E88|rcsb pdb:1E8B|rcsb pdb:1FBR|rcsb pdb:1FNA|rcsb pdb:1FNF|rcsb pdb:1FNH|rcsb pdb:1J8K|rcsb pdb:1O9A|rcsb pdb:1OWW|rcsb pdb:1Q38|rcsb pdb:1QGB|rcsb pdb:1QO6|rcsb pdb:1TTF|rcsb pdb:1TTG|rcsb pdb:2CG6|rcsb pdb:2CG7|rcsb pdb:2CK2|rcsb pdb:2CKU|rcsb pdb:2EC3|rcsb pdb:2FN2|rcsb pdb:2FNB|rcsb pdb:2GEE|rcsb pdb:2H41|rcsb pdb:2H45|rcsb pdb:2HA1|rcsb pdb:2MNU|rcsb pdb:2N1K|rcsb pdb:2OCF|rcsb pdb:2RKY|rcsb pdb:2RKZ|rcsb pdb:2RL0|rcsb pdb:3CAL|rcsb pdb:3EJH|rcsb pdb:3GXE|rcsb pdb:3M7P|rcsb pdb:3MQL|rcsb pdb:3R8Q|rcsb pdb:3T1W|rcsb pdb:3ZRZ|rcsb pdb:4GH7|rcsb pdb:4JE4|rcsb pdb:4JEG|rcsb pdb:4LXO|rcsb pdb:4MMX|rcsb pdb:4MMY|rcsb pdb:4MMZ|rcsb pdb:4PZ5|rcsb pdb:5DC0|rcsb pdb:5DC4|rcsb pdb:5DC9|rcsb pdb:5DFT|rcsb pdb:5J6Z|rcsb pdb:5J7C|rcsb pdb:5M0A|rcsb pdb:5N47|rcsb pdb:5N48|rcsb pdb:6HNF|rcsb pdb:6MFA|rcsb pdb:6MSV|rcsb pdb:6NAJ|rcsb pdb:6XAX|rcsb pdb:6XAY|rcsb pdb:7NWL|reactome:R-HSA-114608|reactome:R-HSA-1474228|reactome:R-HSA-1474244|reactome:R-HSA-1566977|reactome:R-HSA-202733|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-3000170|reactome:R-HSA-3000171|reactome:R-HSA-3000178|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-381426|reactome:R-HSA-5674135|reactome:R-HSA-6785807|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8874081|reactome:R-HSA-8957275|reactome:R-HSA-9649948|reactome:R-HSA-9656223 refseq:NP_003656.2|refseq:NP_775628.1|ensembl:ENSG00000142748(gene)|ensembl:ENST00000270879(transcript)|go:"GO:0001867"(complement activation, lectin pathway)|go:"GO:0003823"(antigen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0006956"(complement activation)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0043654"(recognition of apoptotic cell)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0072562"(blood microparticle)|go:"GO:1902679"(negative regulation of RNA biosynthetic process)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|interpro:IPR036056|rcsb pdb:1LA5|rcsb pdb:2J5Z|rcsb pdb:2J60|rcsb pdb:2J64|reactome:R-HSA-166662|reactome:R-HSA-166663|reactome:R-HSA-2855086 - - - figure legend:8B|comment:Fibronectin interacting with Ag85A; Ficolin 3 as competitor/inhibitor.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/12/18 2021/03/18 rogid:4arZu49X8b+dthqaX4DIh59V8h09606 rogid:Uqrs95TKW2LaGqmcRkU9cu3v2FA9606 rigid:ZlNzepozXTlaZ9+kgsDE01Ncz3c false - his tag:c-c|sufficient binding region:22-299 - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P02751 uniprotkb:P9WQP3-PRO_0000000214 intact:EBI-1220319|uniprotkb:Q7Z391|uniprotkb:O95609|uniprotkb:O95610|uniprotkb:Q14312|uniprotkb:Q14325|uniprotkb:Q14326|uniprotkb:Q17RV7|uniprotkb:Q585T2|uniprotkb:Q59EH1|uniprotkb:Q60FE4|uniprotkb:Q68DP8|uniprotkb:Q68DP9|uniprotkb:Q68DT4|uniprotkb:Q6LDP6|uniprotkb:Q6MZU5|uniprotkb:Q6N025|uniprotkb:Q6N0A6|uniprotkb:Q86T27|uniprotkb:Q8IVI8|uniprotkb:Q96KP7|uniprotkb:Q96KP8|uniprotkb:Q96KP9|uniprotkb:Q9H1B8|uniprotkb:Q9HAP3|uniprotkb:Q9UMK2|uniprotkb:Q6MZS0|uniprotkb:B7ZLF0|uniprotkb:E9PE77|uniprotkb:E9PG29|uniprotkb:Q564H7|uniprotkb:Q53S27|ensembl:ENSP00000346839 intact:EBI-26878164 psi-mi:finc_human(display_long)|uniprotkb:FN1(gene name)|psi-mi:FN1(display_short)|uniprotkb:FN(gene name synonym)|uniprotkb:Cold-insoluble globulin(gene name synonym) psi-mi:p9wqp3-pro_0000000214(display_long)|uniprotkb:fbpA(gene name)|psi-mi:fbpA(display_short)|uniprotkb:mpt44(gene name synonym)|uniprotkb:MTV026.09c(orf name)|uniprotkb:Rv3804c(locus name)|uniprotkb:"Acyl-CoA:diacylglycerol acyltransferase"(gene name synonym)|uniprotkb:Antigen 85 complex A(gene name synonym)|uniprotkb:Fibronectin-binding protein A(gene name synonym) psi-mi:"MI:0892"(solid phase assay) Świerzko et al. (2016) imex:IM-28818|pubmed:27141819 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:83332(myctu)|taxid:83332("Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-26880710|imex:IM-28818-53 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002017.1|refseq:NP_473375.2|refseq:NP_997639.1|refseq:NP_997641.1|refseq:NP_997643.1|refseq:NP_997647.1|refseq:NP_001293058.1|refseq:NP_001293059.1|refseq:NP_001293060.1|refseq:NP_001293061.1|refseq:XP_005246463.1|dip:DIP-29547N|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009611"(response to wounding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0019899"(enzyme binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0033622"(integrin activation)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0051087"(chaperone binding)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|ensembl:ENSG00000115414(gene)|ensembl:ENST00000354785(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005577"(fibrinogen complex)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006953"(acute-phase response)|go:"GO:0007044"(cell-substrate junction assembly)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007161"(calcium-independent cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071635"(negative regulation of transforming growth factor beta production)|go:"GO:0072378"(blood coagulation, fibrin clot formation)|go:"GO:0072562"(blood microparticle)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1901166"(neural crest cell migration involved in autonomic nervous system development)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|interpro:IPR000083(Fibronectin, type I)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013806(Kringle-like fold)|interpro:IPR036116|interpro:IPR036943|mint:P02751|rcsb pdb:1E88|rcsb pdb:1E8B|rcsb pdb:1FBR|rcsb pdb:1FNA|rcsb pdb:1FNF|rcsb pdb:1FNH|rcsb pdb:1J8K|rcsb pdb:1O9A|rcsb pdb:1OWW|rcsb pdb:1Q38|rcsb pdb:1QGB|rcsb pdb:1QO6|rcsb pdb:1TTF|rcsb pdb:1TTG|rcsb pdb:2CG6|rcsb pdb:2CG7|rcsb pdb:2CK2|rcsb pdb:2CKU|rcsb pdb:2EC3|rcsb pdb:2FN2|rcsb pdb:2FNB|rcsb pdb:2GEE|rcsb pdb:2H41|rcsb pdb:2H45|rcsb pdb:2HA1|rcsb pdb:2MNU|rcsb pdb:2N1K|rcsb pdb:2OCF|rcsb pdb:2RKY|rcsb pdb:2RKZ|rcsb pdb:2RL0|rcsb pdb:3CAL|rcsb pdb:3EJH|rcsb pdb:3GXE|rcsb pdb:3M7P|rcsb pdb:3MQL|rcsb pdb:3R8Q|rcsb pdb:3T1W|rcsb pdb:3ZRZ|rcsb pdb:4GH7|rcsb pdb:4JE4|rcsb pdb:4JEG|rcsb pdb:4LXO|rcsb pdb:4MMX|rcsb pdb:4MMY|rcsb pdb:4MMZ|rcsb pdb:4PZ5|rcsb pdb:5DC0|rcsb pdb:5DC4|rcsb pdb:5DC9|rcsb pdb:5DFT|rcsb pdb:5J6Z|rcsb pdb:5J7C|rcsb pdb:5M0A|rcsb pdb:5N47|rcsb pdb:5N48|rcsb pdb:6HNF|rcsb pdb:6MFA|rcsb pdb:6MSV|rcsb pdb:6NAJ|rcsb pdb:6XAX|rcsb pdb:6XAY|rcsb pdb:7NWL|reactome:R-HSA-114608|reactome:R-HSA-1474228|reactome:R-HSA-1474244|reactome:R-HSA-1566977|reactome:R-HSA-202733|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-3000170|reactome:R-HSA-3000171|reactome:R-HSA-3000178|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-381426|reactome:R-HSA-5674135|reactome:R-HSA-6785807|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8874081|reactome:R-HSA-8957275|reactome:R-HSA-9649948|reactome:R-HSA-9656223 intact:EBI-26878135(chain-parent) - - chain-seq-start:44|chain-seq-end:338 figure legend:8B|comment:Fibronectin interacting with Ag85A; Ficolin 3 as competitor/inhibitor.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/12/18 2021/03/18 rogid:4arZu49X8b+dthqaX4DIh59V8h09606 rogid:Mzt8Fm4pOKzsx7P1aOdMO8CWRag83332 rigid:ZlNzepozXTlaZ9+kgsDE01Ncz3c false - his tag:c-c - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P02751 uniprotkb:O75636 intact:EBI-1220319|uniprotkb:Q7Z391|uniprotkb:O95609|uniprotkb:O95610|uniprotkb:Q14312|uniprotkb:Q14325|uniprotkb:Q14326|uniprotkb:Q17RV7|uniprotkb:Q585T2|uniprotkb:Q59EH1|uniprotkb:Q60FE4|uniprotkb:Q68DP8|uniprotkb:Q68DP9|uniprotkb:Q68DT4|uniprotkb:Q6LDP6|uniprotkb:Q6MZU5|uniprotkb:Q6N025|uniprotkb:Q6N0A6|uniprotkb:Q86T27|uniprotkb:Q8IVI8|uniprotkb:Q96KP7|uniprotkb:Q96KP8|uniprotkb:Q96KP9|uniprotkb:Q9H1B8|uniprotkb:Q9HAP3|uniprotkb:Q9UMK2|uniprotkb:Q6MZS0|uniprotkb:B7ZLF0|uniprotkb:E9PE77|uniprotkb:E9PG29|uniprotkb:Q564H7|uniprotkb:Q53S27|ensembl:ENSP00000346839 intact:EBI-11786958|uniprotkb:Q6IBJ5|uniprotkb:Q8WW86|ensembl:ENSP00000270879 psi-mi:finc_human(display_long)|uniprotkb:FN1(gene name)|psi-mi:FN1(display_short)|uniprotkb:FN(gene name synonym)|uniprotkb:Cold-insoluble globulin(gene name synonym) psi-mi:fcn3_human(display_long)|uniprotkb:FCN3(gene name)|psi-mi:FCN3(display_short)|uniprotkb:FCNH(gene name synonym)|uniprotkb:HAKA1(gene name synonym)|uniprotkb:Collagen/fibrinogen domain-containing lectin 3 p35(gene name synonym)|uniprotkb:Collagen/fibrinogen domain-containing protein 3(gene name synonym)|uniprotkb:Hakata antigen(gene name synonym) psi-mi:"MI:0892"(solid phase assay) Świerzko et al. (2016) imex:IM-28818|pubmed:27141819 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-26880722|imex:IM-28818-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002017.1|refseq:NP_473375.2|refseq:NP_997639.1|refseq:NP_997641.1|refseq:NP_997643.1|refseq:NP_997647.1|refseq:NP_001293058.1|refseq:NP_001293059.1|refseq:NP_001293060.1|refseq:NP_001293061.1|refseq:XP_005246463.1|dip:DIP-29547N|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009611"(response to wounding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0019899"(enzyme binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0033622"(integrin activation)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0051087"(chaperone binding)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|ensembl:ENSG00000115414(gene)|ensembl:ENST00000354785(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005577"(fibrinogen complex)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006953"(acute-phase response)|go:"GO:0007044"(cell-substrate junction assembly)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007161"(calcium-independent cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071635"(negative regulation of transforming growth factor beta production)|go:"GO:0072378"(blood coagulation, fibrin clot formation)|go:"GO:0072562"(blood microparticle)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1901166"(neural crest cell migration involved in autonomic nervous system development)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|interpro:IPR000083(Fibronectin, type I)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013806(Kringle-like fold)|interpro:IPR036116|interpro:IPR036943|mint:P02751|rcsb pdb:1E88|rcsb pdb:1E8B|rcsb pdb:1FBR|rcsb pdb:1FNA|rcsb pdb:1FNF|rcsb pdb:1FNH|rcsb pdb:1J8K|rcsb pdb:1O9A|rcsb pdb:1OWW|rcsb pdb:1Q38|rcsb pdb:1QGB|rcsb pdb:1QO6|rcsb pdb:1TTF|rcsb pdb:1TTG|rcsb pdb:2CG6|rcsb pdb:2CG7|rcsb pdb:2CK2|rcsb pdb:2CKU|rcsb pdb:2EC3|rcsb pdb:2FN2|rcsb pdb:2FNB|rcsb pdb:2GEE|rcsb pdb:2H41|rcsb pdb:2H45|rcsb pdb:2HA1|rcsb pdb:2MNU|rcsb pdb:2N1K|rcsb pdb:2OCF|rcsb pdb:2RKY|rcsb pdb:2RKZ|rcsb pdb:2RL0|rcsb pdb:3CAL|rcsb pdb:3EJH|rcsb pdb:3GXE|rcsb pdb:3M7P|rcsb pdb:3MQL|rcsb pdb:3R8Q|rcsb pdb:3T1W|rcsb pdb:3ZRZ|rcsb pdb:4GH7|rcsb pdb:4JE4|rcsb pdb:4JEG|rcsb pdb:4LXO|rcsb pdb:4MMX|rcsb pdb:4MMY|rcsb pdb:4MMZ|rcsb pdb:4PZ5|rcsb pdb:5DC0|rcsb pdb:5DC4|rcsb pdb:5DC9|rcsb pdb:5DFT|rcsb pdb:5J6Z|rcsb pdb:5J7C|rcsb pdb:5M0A|rcsb pdb:5N47|rcsb pdb:5N48|rcsb pdb:6HNF|rcsb pdb:6MFA|rcsb pdb:6MSV|rcsb pdb:6NAJ|rcsb pdb:6XAX|rcsb pdb:6XAY|rcsb pdb:7NWL|reactome:R-HSA-114608|reactome:R-HSA-1474228|reactome:R-HSA-1474244|reactome:R-HSA-1566977|reactome:R-HSA-202733|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-3000170|reactome:R-HSA-3000171|reactome:R-HSA-3000178|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-381426|reactome:R-HSA-5674135|reactome:R-HSA-6785807|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8874081|reactome:R-HSA-8957275|reactome:R-HSA-9649948|reactome:R-HSA-9656223 refseq:NP_003656.2|refseq:NP_775628.1|ensembl:ENSG00000142748(gene)|ensembl:ENST00000270879(transcript)|go:"GO:0001867"(complement activation, lectin pathway)|go:"GO:0003823"(antigen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0006956"(complement activation)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0043654"(recognition of apoptotic cell)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0072562"(blood microparticle)|go:"GO:1902679"(negative regulation of RNA biosynthetic process)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|interpro:IPR036056|rcsb pdb:1LA5|rcsb pdb:2J5Z|rcsb pdb:2J60|rcsb pdb:2J64|reactome:R-HSA-166662|reactome:R-HSA-166663|reactome:R-HSA-2855086 - - - figure legend:8C|comment:Fibronectin interacting with Ficolin 3;Ag85A as a competitor/inhibitor.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/12/18 2021/03/18 rogid:4arZu49X8b+dthqaX4DIh59V8h09606 rogid:Uqrs95TKW2LaGqmcRkU9cu3v2FA9606 rigid:ZlNzepozXTlaZ9+kgsDE01Ncz3c false - his tag:c-c|sufficient binding region:22-299 - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P02751 uniprotkb:P9WQP3-PRO_0000000214 intact:EBI-1220319|uniprotkb:Q7Z391|uniprotkb:O95609|uniprotkb:O95610|uniprotkb:Q14312|uniprotkb:Q14325|uniprotkb:Q14326|uniprotkb:Q17RV7|uniprotkb:Q585T2|uniprotkb:Q59EH1|uniprotkb:Q60FE4|uniprotkb:Q68DP8|uniprotkb:Q68DP9|uniprotkb:Q68DT4|uniprotkb:Q6LDP6|uniprotkb:Q6MZU5|uniprotkb:Q6N025|uniprotkb:Q6N0A6|uniprotkb:Q86T27|uniprotkb:Q8IVI8|uniprotkb:Q96KP7|uniprotkb:Q96KP8|uniprotkb:Q96KP9|uniprotkb:Q9H1B8|uniprotkb:Q9HAP3|uniprotkb:Q9UMK2|uniprotkb:Q6MZS0|uniprotkb:B7ZLF0|uniprotkb:E9PE77|uniprotkb:E9PG29|uniprotkb:Q564H7|uniprotkb:Q53S27|ensembl:ENSP00000346839 intact:EBI-26878164 psi-mi:finc_human(display_long)|uniprotkb:FN1(gene name)|psi-mi:FN1(display_short)|uniprotkb:FN(gene name synonym)|uniprotkb:Cold-insoluble globulin(gene name synonym) psi-mi:p9wqp3-pro_0000000214(display_long)|uniprotkb:fbpA(gene name)|psi-mi:fbpA(display_short)|uniprotkb:mpt44(gene name synonym)|uniprotkb:MTV026.09c(orf name)|uniprotkb:Rv3804c(locus name)|uniprotkb:"Acyl-CoA:diacylglycerol acyltransferase"(gene name synonym)|uniprotkb:Antigen 85 complex A(gene name synonym)|uniprotkb:Fibronectin-binding protein A(gene name synonym) psi-mi:"MI:0892"(solid phase assay) Świerzko et al. (2016) imex:IM-28818|pubmed:27141819 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:83332(myctu)|taxid:83332("Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-26880722|imex:IM-28818-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0941"(competitor) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002017.1|refseq:NP_473375.2|refseq:NP_997639.1|refseq:NP_997641.1|refseq:NP_997643.1|refseq:NP_997647.1|refseq:NP_001293058.1|refseq:NP_001293059.1|refseq:NP_001293060.1|refseq:NP_001293061.1|refseq:XP_005246463.1|dip:DIP-29547N|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009611"(response to wounding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0019899"(enzyme binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0033622"(integrin activation)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0051087"(chaperone binding)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|ensembl:ENSG00000115414(gene)|ensembl:ENST00000354785(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005577"(fibrinogen complex)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006953"(acute-phase response)|go:"GO:0007044"(cell-substrate junction assembly)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007161"(calcium-independent cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071635"(negative regulation of transforming growth factor beta production)|go:"GO:0072378"(blood coagulation, fibrin clot formation)|go:"GO:0072562"(blood microparticle)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1901166"(neural crest cell migration involved in autonomic nervous system development)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|interpro:IPR000083(Fibronectin, type I)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013806(Kringle-like fold)|interpro:IPR036116|interpro:IPR036943|mint:P02751|rcsb pdb:1E88|rcsb pdb:1E8B|rcsb pdb:1FBR|rcsb pdb:1FNA|rcsb pdb:1FNF|rcsb pdb:1FNH|rcsb pdb:1J8K|rcsb pdb:1O9A|rcsb pdb:1OWW|rcsb pdb:1Q38|rcsb pdb:1QGB|rcsb pdb:1QO6|rcsb pdb:1TTF|rcsb pdb:1TTG|rcsb pdb:2CG6|rcsb pdb:2CG7|rcsb pdb:2CK2|rcsb pdb:2CKU|rcsb pdb:2EC3|rcsb pdb:2FN2|rcsb pdb:2FNB|rcsb pdb:2GEE|rcsb pdb:2H41|rcsb pdb:2H45|rcsb pdb:2HA1|rcsb pdb:2MNU|rcsb pdb:2N1K|rcsb pdb:2OCF|rcsb pdb:2RKY|rcsb pdb:2RKZ|rcsb pdb:2RL0|rcsb pdb:3CAL|rcsb pdb:3EJH|rcsb pdb:3GXE|rcsb pdb:3M7P|rcsb pdb:3MQL|rcsb pdb:3R8Q|rcsb pdb:3T1W|rcsb pdb:3ZRZ|rcsb pdb:4GH7|rcsb pdb:4JE4|rcsb pdb:4JEG|rcsb pdb:4LXO|rcsb pdb:4MMX|rcsb pdb:4MMY|rcsb pdb:4MMZ|rcsb pdb:4PZ5|rcsb pdb:5DC0|rcsb pdb:5DC4|rcsb pdb:5DC9|rcsb pdb:5DFT|rcsb pdb:5J6Z|rcsb pdb:5J7C|rcsb pdb:5M0A|rcsb pdb:5N47|rcsb pdb:5N48|rcsb pdb:6HNF|rcsb pdb:6MFA|rcsb pdb:6MSV|rcsb pdb:6NAJ|rcsb pdb:6XAX|rcsb pdb:6XAY|rcsb pdb:7NWL|reactome:R-HSA-114608|reactome:R-HSA-1474228|reactome:R-HSA-1474244|reactome:R-HSA-1566977|reactome:R-HSA-202733|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-3000170|reactome:R-HSA-3000171|reactome:R-HSA-3000178|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-381426|reactome:R-HSA-5674135|reactome:R-HSA-6785807|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8874081|reactome:R-HSA-8957275|reactome:R-HSA-9649948|reactome:R-HSA-9656223 intact:EBI-26878135(chain-parent) - - chain-seq-start:44|chain-seq-end:338 figure legend:8C|comment:Fibronectin interacting with Ficolin 3;Ag85A as a competitor/inhibitor.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/12/18 2021/03/18 rogid:4arZu49X8b+dthqaX4DIh59V8h09606 rogid:Mzt8Fm4pOKzsx7P1aOdMO8CWRag83332 rigid:ZlNzepozXTlaZ9+kgsDE01Ncz3c false - his tag:c-c - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) chebi:"CHEBI:59524" uniprotkb:P11226-PRO_0000017401 intact:EBI-26878120 intact:EBI-25427940 psi-mi:lipoarabinomannan(display_short)|psi-mi:"CHEBI:59524"(display_long)|intact:LAMs(synonym)|intact:lipoarabinomannans(synonym)|intact:LAM(synonym) psi-mi:p11226-pro_0000017401(display_long)|uniprotkb:Collectin-1(gene name synonym)|uniprotkb:MBP1(gene name synonym)|uniprotkb:Mannan-binding protein(gene name synonym)|uniprotkb:Mannose-binding lectin(gene name synonym)|uniprotkb:MBL2(gene name)|psi-mi:MBL2(display_short)|uniprotkb:COLEC1(gene name synonym)|uniprotkb:MBL(gene name synonym) psi-mi:"MI:0047"(far western blotting) Świerzko et al. (2016) imex:IM-28818|pubmed:27141819 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26878280|imex:IM-28818-27 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - intact:EBI-5325353(chain-parent) - - chain-seq-start:21|chain-seq-end:248 figure legend:4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/12/18 2021/04/19 - rogid:niwSuVS9f0s8HBqDB7SSsrtneS89606 - false carbohydrate chemical modification:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P11226-PRO_0000017401 uniprotkb:P9WQP1 intact:EBI-25427940 intact:EBI-26878221|uniprotkb:D6MJP5|uniprotkb:F2GHQ8|uniprotkb:P0C5B9|uniprotkb:P31952|uniprotkb:Q9RMI0 psi-mi:p11226-pro_0000017401(display_long)|uniprotkb:Collectin-1(gene name synonym)|uniprotkb:MBP1(gene name synonym)|uniprotkb:Mannan-binding protein(gene name synonym)|uniprotkb:Mannose-binding lectin(gene name synonym)|uniprotkb:MBL2(gene name)|psi-mi:MBL2(display_short)|uniprotkb:COLEC1(gene name synonym)|uniprotkb:MBL(gene name synonym) psi-mi:a85b_myctu(display_long)|uniprotkb:fbpB(gene name)|psi-mi:fbpB(display_short)|uniprotkb:30 kDa extracellular protein(gene name synonym)|uniprotkb:"Acyl-CoA:diacylglycerol acyltransferase"(gene name synonym)|uniprotkb:Antigen 85 complex B(gene name synonym)|uniprotkb:Extracellular alpha-antigen(gene name synonym)|uniprotkb:Fibronectin-binding protein B(gene name synonym)|uniprotkb:MTCY180.32(orf name)|uniprotkb:Rv1886c(locus name) psi-mi:"MI:0047"(far western blotting) Świerzko et al. (2016) imex:IM-28818|pubmed:27141819 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:83332(myctu)|taxid:83332("Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26878286|imex:IM-28818-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-5325353(chain-parent) go:"GO:0001968"(fibronectin binding)|go:"GO:0004144"(diacylglycerol O-acyltransferase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005618"(cell wall)|go:"GO:0005886"(plasma membrane)|go:"GO:0010756"(positive regulation of plasminogen activation)|go:"GO:0016747"(acyltransferase activity, transferring groups other than amino-acyl groups)|go:"GO:0035375"(zymogen binding)|go:"GO:0040009"(regulation of growth rate)|go:"GO:0046677"(response to antibiotic)|go:"GO:0050348"(trehalose O-mycolyltransferase activity)|go:"GO:0052572"(response to host immune response)|go:"GO:0071769"(mycolate cell wall layer assembly)|refseq:NP_216402.1|refseq:WP_003409456.1|rcsb pdb:1F0N|rcsb pdb:1F0P|rcsb pdb:5TRZ|rcsb pdb:5TS1|interpro:IPR029058|interpro:IPR000801(Putative esterase) - chain-seq-start:21|chain-seq-end:248 - figure legend:4|comment:Ag85B with MBL|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/12/18 2021/03/18 rogid:niwSuVS9f0s8HBqDB7SSsrtneS89606 rogid:5szrASs87LZuw0JpQGKhPP+lcFU83332 rigid:a8BEIwdxTRqTc0e19FCPl24rpjk false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:O00602-PRO_0000009136 uniprotkb:P9WQP1 intact:EBI-11784425 intact:EBI-26878221|uniprotkb:D6MJP5|uniprotkb:F2GHQ8|uniprotkb:P0C5B9|uniprotkb:P31952|uniprotkb:Q9RMI0 psi-mi:o00602-pro_0000009136(display_long)|uniprotkb:FCN1(gene name)|psi-mi:FCN1(display_short)|uniprotkb:FCNM(gene name synonym)|uniprotkb:Collagen/fibrinogen domain-containing protein 1(gene name synonym)|uniprotkb:Ficolin-A(gene name synonym)|uniprotkb:Ficolin-alpha(gene name synonym)|uniprotkb:M-ficolin(gene name synonym) psi-mi:a85b_myctu(display_long)|uniprotkb:fbpB(gene name)|psi-mi:fbpB(display_short)|uniprotkb:30 kDa extracellular protein(gene name synonym)|uniprotkb:"Acyl-CoA:diacylglycerol acyltransferase"(gene name synonym)|uniprotkb:Antigen 85 complex B(gene name synonym)|uniprotkb:Extracellular alpha-antigen(gene name synonym)|uniprotkb:Fibronectin-binding protein B(gene name synonym)|uniprotkb:MTCY180.32(orf name)|uniprotkb:Rv1886c(locus name) psi-mi:"MI:0047"(far western blotting) Świerzko et al. (2016) imex:IM-28818|pubmed:27141819 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:83332(myctu)|taxid:83332("Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26878291|imex:IM-28818-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-5282479(chain-parent) go:"GO:0001968"(fibronectin binding)|go:"GO:0004144"(diacylglycerol O-acyltransferase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005618"(cell wall)|go:"GO:0005886"(plasma membrane)|go:"GO:0010756"(positive regulation of plasminogen activation)|go:"GO:0016747"(acyltransferase activity, transferring groups other than amino-acyl groups)|go:"GO:0035375"(zymogen binding)|go:"GO:0040009"(regulation of growth rate)|go:"GO:0046677"(response to antibiotic)|go:"GO:0050348"(trehalose O-mycolyltransferase activity)|go:"GO:0052572"(response to host immune response)|go:"GO:0071769"(mycolate cell wall layer assembly)|refseq:NP_216402.1|refseq:WP_003409456.1|rcsb pdb:1F0N|rcsb pdb:1F0P|rcsb pdb:5TRZ|rcsb pdb:5TS1|interpro:IPR029058|interpro:IPR000801(Putative esterase) - chain-seq-start:30|chain-seq-end:326 - figure legend:4|comment:Ag85B with Ficolin 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/12/18 2021/03/18 rogid:lTaQw2TU6drH0Rwv4iOyx5zQXZo9606 rogid:5szrASs87LZuw0JpQGKhPP+lcFU83332 rigid:81w4NojGXWr7PfV3tKi5l+LD0sw false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q15485 uniprotkb:P9WQP1 intact:EBI-7468784|uniprotkb:A6NFG7|uniprotkb:Q9UC57|uniprotkb:Q6IS69|intact:MINT-5223224|uniprotkb:Q7M4P4|uniprotkb:A8K478|ensembl:ENSP00000291744 intact:EBI-26878221|uniprotkb:D6MJP5|uniprotkb:F2GHQ8|uniprotkb:P0C5B9|uniprotkb:P31952|uniprotkb:Q9RMI0 psi-mi:fcn2_human(display_long)|uniprotkb:FCN2(gene name)|psi-mi:FCN2(display_short)|uniprotkb:FCNL(gene name synonym)|uniprotkb:Ficolin-B(gene name synonym)|uniprotkb:Ficolin-beta(gene name synonym)|uniprotkb:L-ficolin(gene name synonym)|uniprotkb:Collagen/fibrinogen domain-containing protein 2(gene name synonym)|uniprotkb:Serum lectin p35(gene name synonym)|uniprotkb:37 kDa elastin-binding protein(gene name synonym)|uniprotkb:EBP-37(gene name synonym)|uniprotkb:Hucolin(gene name synonym) psi-mi:a85b_myctu(display_long)|uniprotkb:fbpB(gene name)|psi-mi:fbpB(display_short)|uniprotkb:30 kDa extracellular protein(gene name synonym)|uniprotkb:"Acyl-CoA:diacylglycerol acyltransferase"(gene name synonym)|uniprotkb:Antigen 85 complex B(gene name synonym)|uniprotkb:Extracellular alpha-antigen(gene name synonym)|uniprotkb:Fibronectin-binding protein B(gene name synonym)|uniprotkb:MTCY180.32(orf name)|uniprotkb:Rv1886c(locus name) psi-mi:"MI:0047"(far western blotting) Świerzko et al. (2016) imex:IM-28818|pubmed:27141819 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:83332(myctu)|taxid:83332("Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26878296|imex:IM-28818-29 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004099.2|refseq:NP_056652.1|ensembl:ENSG00000160339(gene)|ensembl:ENST00000291744(transcript)|go:"GO:0001867"(complement activation, lectin pathway)|go:"GO:0003823"(antigen binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0008228"(opsonization)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0043654"(recognition of apoptotic cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0097367"(carbohydrate derivative binding)|go:"GO:2001065"(mannan binding)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|interpro:IPR036056|mint:Q15485|rcsb pdb:2J0G|rcsb pdb:2J0H|rcsb pdb:2J0Y|rcsb pdb:2J1G|rcsb pdb:2J2P|rcsb pdb:2J3F|rcsb pdb:2J3G|rcsb pdb:2J3O|rcsb pdb:2J3U|rcsb pdb:2J61|rcsb pdb:4NYT|rcsb pdb:4R9J|rcsb pdb:4R9T|reactome:R-HSA-166662|reactome:R-HSA-166663|reactome:R-HSA-2855086 go:"GO:0001968"(fibronectin binding)|go:"GO:0004144"(diacylglycerol O-acyltransferase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005618"(cell wall)|go:"GO:0005886"(plasma membrane)|go:"GO:0010756"(positive regulation of plasminogen activation)|go:"GO:0016747"(acyltransferase activity, transferring groups other than amino-acyl groups)|go:"GO:0035375"(zymogen binding)|go:"GO:0040009"(regulation of growth rate)|go:"GO:0046677"(response to antibiotic)|go:"GO:0050348"(trehalose O-mycolyltransferase activity)|go:"GO:0052572"(response to host immune response)|go:"GO:0071769"(mycolate cell wall layer assembly)|refseq:NP_216402.1|refseq:WP_003409456.1|rcsb pdb:1F0N|rcsb pdb:1F0P|rcsb pdb:5TRZ|rcsb pdb:5TS1|interpro:IPR029058|interpro:IPR000801(Putative esterase) - comment:mint|function:Calcium-dependent and GlcNAc-binding lectin. Enhanced phagocytosis of S.typhimurium by neutrophils, suggesting an opsonic effect via the collagen region - figure legend:4|comment:Ag85B with Ficolin 2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/12/18 2021/03/18 rogid:j6vRtYG3I6cn0c2TId/73bE/1To9606 rogid:5szrASs87LZuw0JpQGKhPP+lcFU83332 rigid:8shUNR4yIHWvmZYzS5Ji2dKoCKc false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:O75636 uniprotkb:P9WQP1 intact:EBI-11786958|uniprotkb:Q6IBJ5|uniprotkb:Q8WW86|ensembl:ENSP00000270879 intact:EBI-26878221|uniprotkb:D6MJP5|uniprotkb:F2GHQ8|uniprotkb:P0C5B9|uniprotkb:P31952|uniprotkb:Q9RMI0 psi-mi:fcn3_human(display_long)|uniprotkb:FCN3(gene name)|psi-mi:FCN3(display_short)|uniprotkb:FCNH(gene name synonym)|uniprotkb:HAKA1(gene name synonym)|uniprotkb:Collagen/fibrinogen domain-containing lectin 3 p35(gene name synonym)|uniprotkb:Collagen/fibrinogen domain-containing protein 3(gene name synonym)|uniprotkb:Hakata antigen(gene name synonym) psi-mi:a85b_myctu(display_long)|uniprotkb:fbpB(gene name)|psi-mi:fbpB(display_short)|uniprotkb:30 kDa extracellular protein(gene name synonym)|uniprotkb:"Acyl-CoA:diacylglycerol acyltransferase"(gene name synonym)|uniprotkb:Antigen 85 complex B(gene name synonym)|uniprotkb:Extracellular alpha-antigen(gene name synonym)|uniprotkb:Fibronectin-binding protein B(gene name synonym)|uniprotkb:MTCY180.32(orf name)|uniprotkb:Rv1886c(locus name) psi-mi:"MI:0047"(far western blotting) Świerzko et al. (2016) imex:IM-28818|pubmed:27141819 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:83332(myctu)|taxid:83332("Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26878301|imex:IM-28818-31 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003656.2|refseq:NP_775628.1|ensembl:ENSG00000142748(gene)|ensembl:ENST00000270879(transcript)|go:"GO:0001867"(complement activation, lectin pathway)|go:"GO:0003823"(antigen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0006956"(complement activation)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0043654"(recognition of apoptotic cell)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0072562"(blood microparticle)|go:"GO:1902679"(negative regulation of RNA biosynthetic process)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|interpro:IPR036056|rcsb pdb:1LA5|rcsb pdb:2J5Z|rcsb pdb:2J60|rcsb pdb:2J64|reactome:R-HSA-166662|reactome:R-HSA-166663|reactome:R-HSA-2855086 go:"GO:0001968"(fibronectin binding)|go:"GO:0004144"(diacylglycerol O-acyltransferase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005618"(cell wall)|go:"GO:0005886"(plasma membrane)|go:"GO:0010756"(positive regulation of plasminogen activation)|go:"GO:0016747"(acyltransferase activity, transferring groups other than amino-acyl groups)|go:"GO:0035375"(zymogen binding)|go:"GO:0040009"(regulation of growth rate)|go:"GO:0046677"(response to antibiotic)|go:"GO:0050348"(trehalose O-mycolyltransferase activity)|go:"GO:0052572"(response to host immune response)|go:"GO:0071769"(mycolate cell wall layer assembly)|refseq:NP_216402.1|refseq:WP_003409456.1|rcsb pdb:1F0N|rcsb pdb:1F0P|rcsb pdb:5TRZ|rcsb pdb:5TS1|interpro:IPR029058|interpro:IPR000801(Putative esterase) - - - figure legend:4|comment:Ag85B with Ficolin 3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/12/18 2021/03/18 rogid:Uqrs95TKW2LaGqmcRkU9cu3v2FA9606 rogid:5szrASs87LZuw0JpQGKhPP+lcFU83332 rigid:W5F83kFpK9pcJi1AvN5vHvkFkO4 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:O00602-PRO_0000009136 uniprotkb:P9WQP1 intact:EBI-11784425 intact:EBI-26878221|uniprotkb:D6MJP5|uniprotkb:F2GHQ8|uniprotkb:P0C5B9|uniprotkb:P31952|uniprotkb:Q9RMI0 psi-mi:o00602-pro_0000009136(display_long)|uniprotkb:FCN1(gene name)|psi-mi:FCN1(display_short)|uniprotkb:FCNM(gene name synonym)|uniprotkb:Collagen/fibrinogen domain-containing protein 1(gene name synonym)|uniprotkb:Ficolin-A(gene name synonym)|uniprotkb:Ficolin-alpha(gene name synonym)|uniprotkb:M-ficolin(gene name synonym) psi-mi:a85b_myctu(display_long)|uniprotkb:fbpB(gene name)|psi-mi:fbpB(display_short)|uniprotkb:30 kDa extracellular protein(gene name synonym)|uniprotkb:"Acyl-CoA:diacylglycerol acyltransferase"(gene name synonym)|uniprotkb:Antigen 85 complex B(gene name synonym)|uniprotkb:Extracellular alpha-antigen(gene name synonym)|uniprotkb:Fibronectin-binding protein B(gene name synonym)|uniprotkb:MTCY180.32(orf name)|uniprotkb:Rv1886c(locus name) psi-mi:"MI:0107"(surface plasmon resonance) Świerzko et al. (2016) imex:IM-28818|pubmed:27141819 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:83332(myctu)|taxid:83332("Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26878402|imex:IM-28818-45 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-5282479(chain-parent) go:"GO:0001968"(fibronectin binding)|go:"GO:0004144"(diacylglycerol O-acyltransferase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005618"(cell wall)|go:"GO:0005886"(plasma membrane)|go:"GO:0010756"(positive regulation of plasminogen activation)|go:"GO:0016747"(acyltransferase activity, transferring groups other than amino-acyl groups)|go:"GO:0035375"(zymogen binding)|go:"GO:0040009"(regulation of growth rate)|go:"GO:0046677"(response to antibiotic)|go:"GO:0050348"(trehalose O-mycolyltransferase activity)|go:"GO:0052572"(response to host immune response)|go:"GO:0071769"(mycolate cell wall layer assembly)|refseq:NP_216402.1|refseq:WP_003409456.1|rcsb pdb:1F0N|rcsb pdb:1F0P|rcsb pdb:5TRZ|rcsb pdb:5TS1|interpro:IPR029058|interpro:IPR000801(Putative esterase) - chain-seq-start:30|chain-seq-end:326 - figure legend:5, Table 1|comment:Ag85B with Ficolin 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:6.3x10^-8(molar) 2020/12/18 2021/03/18 rogid:lTaQw2TU6drH0Rwv4iOyx5zQXZo9606 rogid:5szrASs87LZuw0JpQGKhPP+lcFU83332 rigid:81w4NojGXWr7PfV3tKi5l+LD0sw false - - 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q15485 uniprotkb:P9WQP1 intact:EBI-7468784|uniprotkb:A6NFG7|uniprotkb:Q9UC57|uniprotkb:Q6IS69|intact:MINT-5223224|uniprotkb:Q7M4P4|uniprotkb:A8K478|ensembl:ENSP00000291744 intact:EBI-26878221|uniprotkb:D6MJP5|uniprotkb:F2GHQ8|uniprotkb:P0C5B9|uniprotkb:P31952|uniprotkb:Q9RMI0 psi-mi:fcn2_human(display_long)|uniprotkb:FCN2(gene name)|psi-mi:FCN2(display_short)|uniprotkb:FCNL(gene name synonym)|uniprotkb:Ficolin-B(gene name synonym)|uniprotkb:Ficolin-beta(gene name synonym)|uniprotkb:L-ficolin(gene name synonym)|uniprotkb:Collagen/fibrinogen domain-containing protein 2(gene name synonym)|uniprotkb:Serum lectin p35(gene name synonym)|uniprotkb:37 kDa elastin-binding protein(gene name synonym)|uniprotkb:EBP-37(gene name synonym)|uniprotkb:Hucolin(gene name synonym) psi-mi:a85b_myctu(display_long)|uniprotkb:fbpB(gene name)|psi-mi:fbpB(display_short)|uniprotkb:30 kDa extracellular protein(gene name synonym)|uniprotkb:"Acyl-CoA:diacylglycerol acyltransferase"(gene name synonym)|uniprotkb:Antigen 85 complex B(gene name synonym)|uniprotkb:Extracellular alpha-antigen(gene name synonym)|uniprotkb:Fibronectin-binding protein B(gene name synonym)|uniprotkb:MTCY180.32(orf name)|uniprotkb:Rv1886c(locus name) psi-mi:"MI:0107"(surface plasmon resonance) Świerzko et al. (2016) imex:IM-28818|pubmed:27141819 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:83332(myctu)|taxid:83332("Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26878407|imex:IM-28818-47 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004099.2|refseq:NP_056652.1|ensembl:ENSG00000160339(gene)|ensembl:ENST00000291744(transcript)|go:"GO:0001867"(complement activation, lectin pathway)|go:"GO:0003823"(antigen binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0008228"(opsonization)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0043654"(recognition of apoptotic cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0097367"(carbohydrate derivative binding)|go:"GO:2001065"(mannan binding)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|interpro:IPR036056|mint:Q15485|rcsb pdb:2J0G|rcsb pdb:2J0H|rcsb pdb:2J0Y|rcsb pdb:2J1G|rcsb pdb:2J2P|rcsb pdb:2J3F|rcsb pdb:2J3G|rcsb pdb:2J3O|rcsb pdb:2J3U|rcsb pdb:2J61|rcsb pdb:4NYT|rcsb pdb:4R9J|rcsb pdb:4R9T|reactome:R-HSA-166662|reactome:R-HSA-166663|reactome:R-HSA-2855086 go:"GO:0001968"(fibronectin binding)|go:"GO:0004144"(diacylglycerol O-acyltransferase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005618"(cell wall)|go:"GO:0005886"(plasma membrane)|go:"GO:0010756"(positive regulation of plasminogen activation)|go:"GO:0016747"(acyltransferase activity, transferring groups other than amino-acyl groups)|go:"GO:0035375"(zymogen binding)|go:"GO:0040009"(regulation of growth rate)|go:"GO:0046677"(response to antibiotic)|go:"GO:0050348"(trehalose O-mycolyltransferase activity)|go:"GO:0052572"(response to host immune response)|go:"GO:0071769"(mycolate cell wall layer assembly)|refseq:NP_216402.1|refseq:WP_003409456.1|rcsb pdb:1F0N|rcsb pdb:1F0P|rcsb pdb:5TRZ|rcsb pdb:5TS1|interpro:IPR029058|interpro:IPR000801(Putative esterase) - comment:mint|function:Calcium-dependent and GlcNAc-binding lectin. Enhanced phagocytosis of S.typhimurium by neutrophils, suggesting an opsonic effect via the collagen region - figure legend:5, table 1|comment:Ag85B with Ficolin 2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:6.2x10^-8(molar) 2020/12/18 2021/03/18 rogid:j6vRtYG3I6cn0c2TId/73bE/1To9606 rogid:5szrASs87LZuw0JpQGKhPP+lcFU83332 rigid:8shUNR4yIHWvmZYzS5Ji2dKoCKc false - - 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O75636 uniprotkb:P9WQP1 intact:EBI-11786958|uniprotkb:Q6IBJ5|uniprotkb:Q8WW86|ensembl:ENSP00000270879 intact:EBI-26878221|uniprotkb:D6MJP5|uniprotkb:F2GHQ8|uniprotkb:P0C5B9|uniprotkb:P31952|uniprotkb:Q9RMI0 psi-mi:fcn3_human(display_long)|uniprotkb:FCN3(gene name)|psi-mi:FCN3(display_short)|uniprotkb:FCNH(gene name synonym)|uniprotkb:HAKA1(gene name synonym)|uniprotkb:Collagen/fibrinogen domain-containing lectin 3 p35(gene name synonym)|uniprotkb:Collagen/fibrinogen domain-containing protein 3(gene name synonym)|uniprotkb:Hakata antigen(gene name synonym) psi-mi:a85b_myctu(display_long)|uniprotkb:fbpB(gene name)|psi-mi:fbpB(display_short)|uniprotkb:30 kDa extracellular protein(gene name synonym)|uniprotkb:"Acyl-CoA:diacylglycerol acyltransferase"(gene name synonym)|uniprotkb:Antigen 85 complex B(gene name synonym)|uniprotkb:Extracellular alpha-antigen(gene name synonym)|uniprotkb:Fibronectin-binding protein B(gene name synonym)|uniprotkb:MTCY180.32(orf name)|uniprotkb:Rv1886c(locus name) psi-mi:"MI:0107"(surface plasmon resonance) Świerzko et al. (2016) imex:IM-28818|pubmed:27141819 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:83332(myctu)|taxid:83332("Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26878412|imex:IM-28818-49 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003656.2|refseq:NP_775628.1|ensembl:ENSG00000142748(gene)|ensembl:ENST00000270879(transcript)|go:"GO:0001867"(complement activation, lectin pathway)|go:"GO:0003823"(antigen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0006956"(complement activation)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0043654"(recognition of apoptotic cell)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0072562"(blood microparticle)|go:"GO:1902679"(negative regulation of RNA biosynthetic process)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|interpro:IPR036056|rcsb pdb:1LA5|rcsb pdb:2J5Z|rcsb pdb:2J60|rcsb pdb:2J64|reactome:R-HSA-166662|reactome:R-HSA-166663|reactome:R-HSA-2855086 go:"GO:0001968"(fibronectin binding)|go:"GO:0004144"(diacylglycerol O-acyltransferase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005618"(cell wall)|go:"GO:0005886"(plasma membrane)|go:"GO:0010756"(positive regulation of plasminogen activation)|go:"GO:0016747"(acyltransferase activity, transferring groups other than amino-acyl groups)|go:"GO:0035375"(zymogen binding)|go:"GO:0040009"(regulation of growth rate)|go:"GO:0046677"(response to antibiotic)|go:"GO:0050348"(trehalose O-mycolyltransferase activity)|go:"GO:0052572"(response to host immune response)|go:"GO:0071769"(mycolate cell wall layer assembly)|refseq:NP_216402.1|refseq:WP_003409456.1|rcsb pdb:1F0N|rcsb pdb:1F0P|rcsb pdb:5TRZ|rcsb pdb:5TS1|interpro:IPR029058|interpro:IPR000801(Putative esterase) - - - figure legend:5, Table 1|comment:Ag85B with Ficolin 3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:7.8x10^-8(molar) 2020/12/18 2021/03/18 rogid:Uqrs95TKW2LaGqmcRkU9cu3v2FA9606 rogid:5szrASs87LZuw0JpQGKhPP+lcFU83332 rigid:W5F83kFpK9pcJi1AvN5vHvkFkO4 false - - 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P9WQP1 uniprotkb:O75636 intact:EBI-26878221|uniprotkb:D6MJP5|uniprotkb:F2GHQ8|uniprotkb:P0C5B9|uniprotkb:P31952|uniprotkb:Q9RMI0 intact:EBI-11786958|uniprotkb:Q6IBJ5|uniprotkb:Q8WW86|ensembl:ENSP00000270879 psi-mi:a85b_myctu(display_long)|uniprotkb:fbpB(gene name)|psi-mi:fbpB(display_short)|uniprotkb:30 kDa extracellular protein(gene name synonym)|uniprotkb:"Acyl-CoA:diacylglycerol acyltransferase"(gene name synonym)|uniprotkb:Antigen 85 complex B(gene name synonym)|uniprotkb:Extracellular alpha-antigen(gene name synonym)|uniprotkb:Fibronectin-binding protein B(gene name synonym)|uniprotkb:MTCY180.32(orf name)|uniprotkb:Rv1886c(locus name) psi-mi:fcn3_human(display_long)|uniprotkb:FCN3(gene name)|psi-mi:FCN3(display_short)|uniprotkb:FCNH(gene name synonym)|uniprotkb:HAKA1(gene name synonym)|uniprotkb:Collagen/fibrinogen domain-containing lectin 3 p35(gene name synonym)|uniprotkb:Collagen/fibrinogen domain-containing protein 3(gene name synonym)|uniprotkb:Hakata antigen(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Świerzko et al. (2016) imex:IM-28818|pubmed:27141819 taxid:83332(myctu)|taxid:83332("Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-26880611|imex:IM-28818-17 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001968"(fibronectin binding)|go:"GO:0004144"(diacylglycerol O-acyltransferase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005618"(cell wall)|go:"GO:0005886"(plasma membrane)|go:"GO:0010756"(positive regulation of plasminogen activation)|go:"GO:0016747"(acyltransferase activity, transferring groups other than amino-acyl groups)|go:"GO:0035375"(zymogen binding)|go:"GO:0040009"(regulation of growth rate)|go:"GO:0046677"(response to antibiotic)|go:"GO:0050348"(trehalose O-mycolyltransferase activity)|go:"GO:0052572"(response to host immune response)|go:"GO:0071769"(mycolate cell wall layer assembly)|refseq:NP_216402.1|refseq:WP_003409456.1|rcsb pdb:1F0N|rcsb pdb:1F0P|rcsb pdb:5TRZ|rcsb pdb:5TS1|interpro:IPR029058|interpro:IPR000801(Putative esterase) refseq:NP_003656.2|refseq:NP_775628.1|ensembl:ENSG00000142748(gene)|ensembl:ENST00000270879(transcript)|go:"GO:0001867"(complement activation, lectin pathway)|go:"GO:0003823"(antigen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0006956"(complement activation)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0043654"(recognition of apoptotic cell)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0072562"(blood microparticle)|go:"GO:1902679"(negative regulation of RNA biosynthetic process)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|interpro:IPR036056|rcsb pdb:1LA5|rcsb pdb:2J5Z|rcsb pdb:2J60|rcsb pdb:2J64|reactome:R-HSA-166662|reactome:R-HSA-166663|reactome:R-HSA-2855086 - - - figure legend:7|comment:Ag85B with Ficolin 3|comment:"Weak interaction; Text states:-\"The black arrow (A panel) marks a subtle band suspected to correspond to Ag85.\""|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:7.8x10^-8(molar) 2020/12/18 2021/03/18 rogid:5szrASs87LZuw0JpQGKhPP+lcFU83332 rogid:Uqrs95TKW2LaGqmcRkU9cu3v2FA9606 rigid:W5F83kFpK9pcJi1AvN5vHvkFkO4 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)