#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q8N4Q1 uniprotkb:Q96BQ5 intact:EBI-2562213|uniprotkb:A8K3Z9|uniprotkb:Q96AI2|uniprotkb:Q96MY6|ensembl:ENSP00000380122 intact:EBI-7219131|intact:MINT-1198594|ensembl:ENSP00000296824 psi-mi:mia40_human(display_long)|uniprotkb:MIA40(gene name synonym)|uniprotkb:Coiled-coil-helix-coiled-coil-helix domain-containing protein 4(gene name synonym)|uniprotkb:CHCHD4(gene name)|psi-mi:CHCHD4(display_short) psi-mi:cc127_human(display_long)|uniprotkb:CCDC127(gene name)|psi-mi:CCDC127(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Petrungaro et al. (2015) pubmed:26387864|imex:IM-28311 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-25744749|imex:IM-28311-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091972.1|refseq:NP_653237.1|ensembl:ENSG00000163528(gene)|ensembl:ENST00000396914(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0018171"(peptidyl-cysteine oxidation)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0045041"(protein import into mitochondrial intermembrane space)|go:"GO:0051084"('de novo' posttranslational protein folding)|interpro:IPR010625(CHCH)|interpro:IPR039289|mint:Q8N4Q1|rcsb pdb:2K3J|rcsb pdb:2L0Y|reactome:R-HSA-1268020|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|dip:DIP-48483N refseq:NP_660308.1|ensembl:ENST00000296824(transcript)|interpro:IPR034607|ensembl:ENSG00000164366(gene) - - comment:mint|comment:homomint comment:CHCHD2/9 also identified but could not be resolved to a single gene product|figure legend:Figure 1C;Tables S1,S2, andS3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens) - 2020/06/30 2020/06/30 rogid:ACH8CTQRjTwq7nz6toGTrn3VHlE9606 rogid:6g9aXdm9BxC971M1P45HmL4gFis9606 rigid:AMletA7dEZzMTF73rieVObCfS9E false strep tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N4Q1 uniprotkb:Q9BPX6 intact:EBI-2562213|uniprotkb:A8K3Z9|uniprotkb:Q96AI2|uniprotkb:Q96MY6|ensembl:ENSP00000380122 intact:EBI-2371996|uniprotkb:O75785|uniprotkb:Q9H9N6|uniprotkb:Q9UFX0|uniprotkb:A8MV96|uniprotkb:B3KN20|uniprotkb:B4DJH9|uniprotkb:B4DPI1|uniprotkb:B5MBY3|uniprotkb:D3YTJ3|ensembl:ENSP00000354415 psi-mi:mia40_human(display_long)|uniprotkb:MIA40(gene name synonym)|uniprotkb:Coiled-coil-helix-coiled-coil-helix domain-containing protein 4(gene name synonym)|uniprotkb:CHCHD4(gene name)|psi-mi:CHCHD4(display_short) psi-mi:micu1_human(display_long)|uniprotkb:MICU1(gene name)|psi-mi:MICU1(display_short)|uniprotkb:Calcium-binding atopy-related autoantigen 1(gene name synonym)|uniprotkb:CBARA1(gene name synonym)|uniprotkb:CALC(gene name synonym)|uniprotkb:Atopy-related autoantigen CALC(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Petrungaro et al. (2015) pubmed:26387864|imex:IM-28311 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-25744749|imex:IM-28311-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091972.1|refseq:NP_653237.1|ensembl:ENSG00000163528(gene)|ensembl:ENST00000396914(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0018171"(peptidyl-cysteine oxidation)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0045041"(protein import into mitochondrial intermembrane space)|go:"GO:0051084"('de novo' posttranslational protein folding)|interpro:IPR010625(CHCH)|interpro:IPR039289|mint:Q8N4Q1|rcsb pdb:2K3J|rcsb pdb:2L0Y|reactome:R-HSA-1268020|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|dip:DIP-48483N refseq:NP_001182447.1|refseq:NP_001182448.1|refseq:NP_006068.2|dip:DIP-53438N|ensembl:ENSG00000107745(gene)|ensembl:ENST00000361114(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005622"(intracellular anatomical structure)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0006952"(defense response)|go:"GO:0032592"(integral component of mitochondrial membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0042802"(identical protein binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0070509"(calcium ion import)|go:"GO:1900069"(regulation of cellular hyperosmotic salinity response)|go:"GO:1990246"(uniplex complex)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR039800|rcsb pdb:4NSC|rcsb pdb:4NSD|rcsb pdb:6K7Y|rcsb pdb:6LB7|rcsb pdb:6LB8|rcsb pdb:6LE5|rcsb pdb:6WDN|rcsb pdb:6WDO|rcsb pdb:6XJX|rcsb pdb:6XQN|rcsb pdb:6XQO|reactome:R-HSA-8949215|reactome:R-HSA-8949664|rcsb pdb:6XJV - - - comment:CHCHD2/9 also identified but could not be resolved to a single gene product|figure legend:Figure 1C;Tables S1,S2, andS3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens) - 2020/06/30 2020/06/30 rogid:ACH8CTQRjTwq7nz6toGTrn3VHlE9606 rogid:ieoktRyh6dR8RvLctKOhbT84qPU9606 rigid:AMletA7dEZzMTF73rieVObCfS9E false strep tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N4Q1 uniprotkb:O43805 intact:EBI-2562213|uniprotkb:A8K3Z9|uniprotkb:Q96AI2|uniprotkb:Q96MY6|ensembl:ENSP00000380122 intact:EBI-2515299|ensembl:ENSP00000313752|uniprotkb:Q9BVW8|uniprotkb:Q6FG70|uniprotkb:Q5VSG0 psi-mi:mia40_human(display_long)|uniprotkb:MIA40(gene name synonym)|uniprotkb:Coiled-coil-helix-coiled-coil-helix domain-containing protein 4(gene name synonym)|uniprotkb:CHCHD4(gene name)|psi-mi:CHCHD4(display_short) psi-mi:ssna1_human(display_long)|uniprotkb:SSNA1(gene name)|psi-mi:SSNA1(display_short)|uniprotkb:NA14(gene name synonym)|uniprotkb:Nuclear autoantigen of 14 kDa(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Petrungaro et al. (2015) pubmed:26387864|imex:IM-28311 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-25744749|imex:IM-28311-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091972.1|refseq:NP_653237.1|ensembl:ENSG00000163528(gene)|ensembl:ENST00000396914(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0018171"(peptidyl-cysteine oxidation)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0045041"(protein import into mitochondrial intermembrane space)|go:"GO:0051084"('de novo' posttranslational protein folding)|interpro:IPR010625(CHCH)|interpro:IPR039289|mint:Q8N4Q1|rcsb pdb:2K3J|rcsb pdb:2L0Y|reactome:R-HSA-1268020|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|dip:DIP-48483N ensembl:ENSG00000176101(gene)|ensembl:ENST00000322310(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042073"(intraciliary transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0060830"(ciliary receptor clustering involved in smoothened signaling pathway)|interpro:IPR033362|mint:O43805|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-8854518|refseq:NP_003722.2 - - - comment:CHCHD2/9 also identified but could not be resolved to a single gene product|figure legend:Figure 1C;Tables S1,S2, andS3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens) - 2020/06/30 2020/06/30 rogid:ACH8CTQRjTwq7nz6toGTrn3VHlE9606 rogid:W48R8M8go89X1aS1L1AHejuOO+g9606 rigid:AMletA7dEZzMTF73rieVObCfS9E false strep tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N4Q1 uniprotkb:O96000 intact:EBI-2562213|uniprotkb:A8K3Z9|uniprotkb:Q96AI2|uniprotkb:Q96MY6|ensembl:ENSP00000380122 intact:EBI-1246371|uniprotkb:Q96II6|ensembl:ENSP00000268668 psi-mi:mia40_human(display_long)|uniprotkb:MIA40(gene name synonym)|uniprotkb:Coiled-coil-helix-coiled-coil-helix domain-containing protein 4(gene name synonym)|uniprotkb:CHCHD4(gene name)|psi-mi:CHCHD4(display_short) psi-mi:nduba_human(display_long)|uniprotkb:NDUFB10(gene name)|psi-mi:NDUFB10(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase PDSW subunit(gene name synonym)|uniprotkb:Complex I-PDSW(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Petrungaro et al. (2015) pubmed:26387864|imex:IM-28311 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-25744749|imex:IM-28311-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091972.1|refseq:NP_653237.1|ensembl:ENSG00000163528(gene)|ensembl:ENST00000396914(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0018171"(peptidyl-cysteine oxidation)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0045041"(protein import into mitochondrial intermembrane space)|go:"GO:0051084"('de novo' posttranslational protein folding)|interpro:IPR010625(CHCH)|interpro:IPR039289|mint:Q8N4Q1|rcsb pdb:2K3J|rcsb pdb:2L0Y|reactome:R-HSA-1268020|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|dip:DIP-48483N refseq:NP_004539.1|ensembl:ENSG00000140990(gene)|ensembl:ENST00000268668(transcript)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|interpro:IPR019377|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR039993|rcsb pdb:5XTC|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198|dip:DIP-38298N - - - comment:CHCHD2/9 also identified but could not be resolved to a single gene product|figure legend:Figure 1C;Tables S1,S2, andS3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens) - 2020/06/30 2020/06/30 rogid:ACH8CTQRjTwq7nz6toGTrn3VHlE9606 rogid:CRQJLj/I1jZSnIU7GeuRDGN4hRA9606 rigid:AMletA7dEZzMTF73rieVObCfS9E false strep tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N4Q1 uniprotkb:Q9NX70 intact:EBI-2562213|uniprotkb:A8K3Z9|uniprotkb:Q96AI2|uniprotkb:Q96MY6|ensembl:ENSP00000380122 intact:EBI-394656|uniprotkb:Q9NTF4|uniprotkb:Q5XX09|uniprotkb:B4DNQ6|uniprotkb:M0R2E4|ensembl:ENSP00000314343 psi-mi:mia40_human(display_long)|uniprotkb:MIA40(gene name synonym)|uniprotkb:Coiled-coil-helix-coiled-coil-helix domain-containing protein 4(gene name synonym)|uniprotkb:CHCHD4(gene name)|psi-mi:CHCHD4(display_short) psi-mi:med29_human(display_long)|uniprotkb:MED29(gene name)|psi-mi:MED29(display_short)|uniprotkb:Mediator complex subunit 29(gene name synonym)|uniprotkb:Intersex-like protein(gene name synonym)|uniprotkb:IXL(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Petrungaro et al. (2015) pubmed:26387864|imex:IM-28311 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-25744749|imex:IM-28311-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091972.1|refseq:NP_653237.1|ensembl:ENSG00000163528(gene)|ensembl:ENST00000396914(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0018171"(peptidyl-cysteine oxidation)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0045041"(protein import into mitochondrial intermembrane space)|go:"GO:0051084"('de novo' posttranslational protein folding)|interpro:IPR010625(CHCH)|interpro:IPR039289|mint:Q8N4Q1|rcsb pdb:2K3J|rcsb pdb:2L0Y|reactome:R-HSA-1268020|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|dip:DIP-48483N refseq:NP_060062.1|refseq:NP_001304699.1|ensembl:ENSG00000063322(gene)|ensembl:ENST00000315588(transcript)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016592"(mediator complex)|interpro:IPR021018|mint:Q9NX70|rcsb pdb:7EMF|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7ENJ|rcsb pdb:7LBM|reactome:R-HSA-1989781|reactome:R-HSA-381340 - - - comment:CHCHD2/9 also identified but could not be resolved to a single gene product|figure legend:Figure 1C;Tables S1,S2, andS3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens) - 2020/06/30 2020/06/30 rogid:ACH8CTQRjTwq7nz6toGTrn3VHlE9606 rogid:WOrt3DAoOape6p0CwWSLIW55hVg9606 rigid:AMletA7dEZzMTF73rieVObCfS9E false strep tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N4Q1 uniprotkb:Q8IWC1 intact:EBI-2562213|uniprotkb:A8K3Z9|uniprotkb:Q96AI2|uniprotkb:Q96MY6|ensembl:ENSP00000380122 intact:EBI-1050284|uniprotkb:A6NCZ7|uniprotkb:A2A2J0|uniprotkb:A6NHR4|uniprotkb:Q5JXI5|uniprotkb:Q5JXI6|uniprotkb:Q9H9M8|uniprotkb:Q6P2S1|uniprotkb:B4DWD2|uniprotkb:H7BY77|ensembl:ENSP00000318086 psi-mi:mia40_human(display_long)|uniprotkb:MIA40(gene name synonym)|uniprotkb:Coiled-coil-helix-coiled-coil-helix domain-containing protein 4(gene name synonym)|uniprotkb:CHCHD4(gene name)|psi-mi:CHCHD4(display_short) psi-mi:ma7d3_human(display_long)|uniprotkb:MAP7D3(gene name)|psi-mi:MAP7D3(display_short)|uniprotkb:MDP3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Petrungaro et al. (2015) pubmed:26387864|imex:IM-28311 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-25744749|imex:IM-28311-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091972.1|refseq:NP_653237.1|ensembl:ENSG00000163528(gene)|ensembl:ENST00000396914(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0018171"(peptidyl-cysteine oxidation)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0045041"(protein import into mitochondrial intermembrane space)|go:"GO:0051084"('de novo' posttranslational protein folding)|interpro:IPR010625(CHCH)|interpro:IPR039289|mint:Q8N4Q1|rcsb pdb:2K3J|rcsb pdb:2L0Y|reactome:R-HSA-1268020|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|dip:DIP-48483N refseq:NP_001166987.1|refseq:NP_001166988.1|refseq:NP_078873.2|ensembl:ENSG00000129680(gene)|ensembl:ENST00000316077(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0008017"(microtubule binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0015631"(tubulin binding)|go:"GO:0016020"(membrane)|go:"GO:0046785"(microtubule polymerization)|interpro:IPR008604(E-MAP-115) - - - comment:CHCHD2/9 also identified but could not be resolved to a single gene product|figure legend:Figure 1C;Tables S1,S2, andS3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens) - 2020/06/30 2020/06/30 rogid:ACH8CTQRjTwq7nz6toGTrn3VHlE9606 rogid:9WwXvs5DT9zh5c7DC27VuemEeU09606 rigid:AMletA7dEZzMTF73rieVObCfS9E false strep tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N4Q1 uniprotkb:Q4VC31 intact:EBI-2562213|uniprotkb:A8K3Z9|uniprotkb:Q96AI2|uniprotkb:Q96MY6|ensembl:ENSP00000380122 intact:EBI-1051617|uniprotkb:Q32LY6|ensembl:ENSP00000291458 psi-mi:mia40_human(display_long)|uniprotkb:MIA40(gene name synonym)|uniprotkb:Coiled-coil-helix-coiled-coil-helix domain-containing protein 4(gene name synonym)|uniprotkb:CHCHD4(gene name)|psi-mi:CHCHD4(display_short) psi-mi:mix23_human(display_long)|uniprotkb:MIX23(gene name)|psi-mi:MIX23(display_short)|uniprotkb:CCDC58(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 58(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Petrungaro et al. (2015) pubmed:26387864|imex:IM-28311 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-25744749|imex:IM-28311-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091972.1|refseq:NP_653237.1|ensembl:ENSG00000163528(gene)|ensembl:ENST00000396914(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0018171"(peptidyl-cysteine oxidation)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0045041"(protein import into mitochondrial intermembrane space)|go:"GO:0051084"('de novo' posttranslational protein folding)|interpro:IPR010625(CHCH)|interpro:IPR039289|mint:Q8N4Q1|rcsb pdb:2K3J|rcsb pdb:2L0Y|reactome:R-HSA-1268020|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|dip:DIP-48483N refseq:NP_001017928.1|refseq:NP_001295255.1|ensembl:ENSG00000160124(gene)|ensembl:ENST00000291458(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|interpro:IPR019171 - - - comment:CHCHD2/9 also identified but could not be resolved to a single gene product|figure legend:Figure 1C;Tables S1,S2, andS3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens) - 2020/06/30 2020/06/30 rogid:ACH8CTQRjTwq7nz6toGTrn3VHlE9606 rogid:gB8FPCT9VG4P1zyieoDNbQbLW2w9606 rigid:AMletA7dEZzMTF73rieVObCfS9E false strep tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N4Q1 uniprotkb:Q96BR5 intact:EBI-2562213|uniprotkb:A8K3Z9|uniprotkb:Q96AI2|uniprotkb:Q96MY6|ensembl:ENSP00000380122 intact:EBI-6269632|ensembl:ENSP00000360593|uniprotkb:Q0P6I7|uniprotkb:Q9H9Z9 psi-mi:mia40_human(display_long)|uniprotkb:MIA40(gene name synonym)|uniprotkb:Coiled-coil-helix-coiled-coil-helix domain-containing protein 4(gene name synonym)|uniprotkb:CHCHD4(gene name)|psi-mi:CHCHD4(display_short) psi-mi:coa7_human(display_long)|uniprotkb:COA7(gene name)|psi-mi:COA7(display_short)|uniprotkb:Beta-lactamase hcp-like protein(gene name synonym)|uniprotkb:C1orf163(gene name synonym)|uniprotkb:RESA1(gene name synonym)|uniprotkb:Respiratory chain assembly factor 1(gene name synonym)|uniprotkb:SELRC1(gene name synonym)|uniprotkb:Sel1 repeat-containing protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Petrungaro et al. (2015) pubmed:26387864|imex:IM-28311 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-25744749|imex:IM-28311-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091972.1|refseq:NP_653237.1|ensembl:ENSG00000163528(gene)|ensembl:ENST00000396914(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0018171"(peptidyl-cysteine oxidation)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0045041"(protein import into mitochondrial intermembrane space)|go:"GO:0051084"('de novo' posttranslational protein folding)|interpro:IPR010625(CHCH)|interpro:IPR039289|mint:Q8N4Q1|rcsb pdb:2K3J|rcsb pdb:2L0Y|reactome:R-HSA-1268020|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|dip:DIP-48483N ensembl:ENSG00000162377(gene)|ensembl:ENST00000371538(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|interpro:IPR006597(Sel1-like)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR040239|refseq:NP_075565.2 - - - comment:CHCHD2/9 also identified but could not be resolved to a single gene product|figure legend:Figure 1C;Tables S1,S2, andS3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens) - 2020/06/30 2020/06/30 rogid:ACH8CTQRjTwq7nz6toGTrn3VHlE9606 rogid:lFzdNRL3Mr9Jhk+/zN6aEyZmfDI9606 rigid:AMletA7dEZzMTF73rieVObCfS9E false strep tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N4Q1 uniprotkb:Q9Y5L4 intact:EBI-2562213|uniprotkb:A8K3Z9|uniprotkb:Q96AI2|uniprotkb:Q96MY6|ensembl:ENSP00000380122 intact:EBI-1057344|uniprotkb:P62206|uniprotkb:Q9UHL8|uniprotkb:Q9WTL1|ensembl:ENSP00000215570 psi-mi:mia40_human(display_long)|uniprotkb:MIA40(gene name synonym)|uniprotkb:Coiled-coil-helix-coiled-coil-helix domain-containing protein 4(gene name synonym)|uniprotkb:CHCHD4(gene name)|psi-mi:CHCHD4(display_short) psi-mi:tim13_human(display_long)|uniprotkb:TIMM13(gene name)|psi-mi:TIMM13(display_short)|uniprotkb:TIM13B(gene name synonym)|uniprotkb:TIMM13A(gene name synonym)|uniprotkb:TIMM13B(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Petrungaro et al. (2015) pubmed:26387864|imex:IM-28311 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-25744749|imex:IM-28311-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091972.1|refseq:NP_653237.1|ensembl:ENSG00000163528(gene)|ensembl:ENST00000396914(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0018171"(peptidyl-cysteine oxidation)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0045041"(protein import into mitochondrial intermembrane space)|go:"GO:0051084"('de novo' posttranslational protein folding)|interpro:IPR010625(CHCH)|interpro:IPR039289|mint:Q8N4Q1|rcsb pdb:2K3J|rcsb pdb:2L0Y|reactome:R-HSA-1268020|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|dip:DIP-48483N refseq:NP_036590.1|ensembl:ENSG00000099800(gene)|ensembl:ENST00000215570(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008270"(zinc ion binding)|go:"GO:0042719"(mitochondrial intermembrane space protein transporter complex)|go:"GO:0045039"(protein insertion into mitochondrial inner membrane)|interpro:IPR004217(Zinc finger, Tim10/DDP-type)|interpro:IPR035427|interpro:IPR039238|mint:Q9Y5L4|reactome:R-HSA-1268020 - - - comment:CHCHD2/9 also identified but could not be resolved to a single gene product|figure legend:Figure 1C;Tables S1,S2, andS3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens) - 2020/06/30 2020/06/30 rogid:ACH8CTQRjTwq7nz6toGTrn3VHlE9606 rogid:kFNYBvKwUM0JECXq9FjvYv55JAM9606 rigid:AMletA7dEZzMTF73rieVObCfS9E false strep tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N4Q1 uniprotkb:P55789 intact:EBI-2562213|uniprotkb:A8K3Z9|uniprotkb:Q96AI2|uniprotkb:Q96MY6|ensembl:ENSP00000380122 intact:EBI-718281|uniprotkb:Q8TAH6|uniprotkb:Q9H290|uniprotkb:Q9UK40|intact:EBI-6137916|uniprotkb:Q53YM6|ensembl:ENSP00000248114 psi-mi:mia40_human(display_long)|uniprotkb:MIA40(gene name synonym)|uniprotkb:Coiled-coil-helix-coiled-coil-helix domain-containing protein 4(gene name synonym)|uniprotkb:CHCHD4(gene name)|psi-mi:CHCHD4(display_short) psi-mi:alr_human(display_long)|uniprotkb:Augmenter of liver regeneration(gene name synonym)|uniprotkb:GFER(gene name)|psi-mi:GFER(display_short)|uniprotkb:ALR(gene name synonym)|uniprotkb:HERV1(gene name synonym)|uniprotkb:HPO(gene name synonym)|uniprotkb:Hepatopoietin(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Petrungaro et al. (2015) pubmed:26387864|imex:IM-28311 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-25744749|imex:IM-28311-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091972.1|refseq:NP_653237.1|ensembl:ENSG00000163528(gene)|ensembl:ENST00000396914(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0018171"(peptidyl-cysteine oxidation)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0045041"(protein import into mitochondrial intermembrane space)|go:"GO:0051084"('de novo' posttranslational protein folding)|interpro:IPR010625(CHCH)|interpro:IPR039289|mint:Q8N4Q1|rcsb pdb:2K3J|rcsb pdb:2L0Y|reactome:R-HSA-1268020|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|dip:DIP-48483N refseq:NP_005253.3|ensembl:ENSG00000127554(gene)|ensembl:ENST00000248114(transcript)|go:"GO:0001889"(liver development)|go:"GO:0005576"(extracellular region)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0008083"(growth factor activity)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0016971"(flavin-linked sulfhydryl oxidase activity)|go:"GO:0050660"(flavin adenine dinucleotide binding)|interpro:IPR017905|interpro:IPR036774|interpro:IPR039799|rcsb pdb:3MBG|rcsb pdb:3O55|rcsb pdb:3TK0|rcsb pdb:3U2L|rcsb pdb:3U2M|rcsb pdb:3U5S|rcsb pdb:4LDK|reactome:R-HSA-1268020 - - - comment:CHCHD2/9 also identified but could not be resolved to a single gene product|figure legend:Figure 1C;Tables S1,S2, andS3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens) - 2020/06/30 2020/06/30 rogid:ACH8CTQRjTwq7nz6toGTrn3VHlE9606 rogid:ttWSaYxpd3WUg61NQC7eiybRFUg9606 rigid:AMletA7dEZzMTF73rieVObCfS9E false strep tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N4Q1 uniprotkb:Q96BQ5 intact:EBI-2562213|uniprotkb:A8K3Z9|uniprotkb:Q96AI2|uniprotkb:Q96MY6|ensembl:ENSP00000380122 intact:EBI-7219131|intact:MINT-1198594|ensembl:ENSP00000296824 psi-mi:mia40_human(display_long)|uniprotkb:MIA40(gene name synonym)|uniprotkb:Coiled-coil-helix-coiled-coil-helix domain-containing protein 4(gene name synonym)|uniprotkb:CHCHD4(gene name)|psi-mi:CHCHD4(display_short) psi-mi:cc127_human(display_long)|uniprotkb:CCDC127(gene name)|psi-mi:CCDC127(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Petrungaro et al. (2015) pubmed:26387864|imex:IM-28311 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-25744959|imex:IM-28311-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091972.1|refseq:NP_653237.1|ensembl:ENSG00000163528(gene)|ensembl:ENST00000396914(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0018171"(peptidyl-cysteine oxidation)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0045041"(protein import into mitochondrial intermembrane space)|go:"GO:0051084"('de novo' posttranslational protein folding)|interpro:IPR010625(CHCH)|interpro:IPR039289|mint:Q8N4Q1|rcsb pdb:2K3J|rcsb pdb:2L0Y|reactome:R-HSA-1268020|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|dip:DIP-48483N refseq:NP_660308.1|ensembl:ENST00000296824(transcript)|interpro:IPR034607|ensembl:ENSG00000164366(gene) - - comment:mint|comment:homomint comment:CHCHD2/9 also identified but could not be resolved to a single gene product|figure legend:Figure 1D;Tables S1,S2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens) - 2020/06/30 2020/07/01 rogid:ACH8CTQRjTwq7nz6toGTrn3VHlE9606 rogid:6g9aXdm9BxC971M1P45HmL4gFis9606 rigid:WRjTrDbZBbp3IZSUoz6Q510SmHc false strep tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N4Q1 uniprotkb:P62072 intact:EBI-2562213|uniprotkb:A8K3Z9|uniprotkb:Q96AI2|uniprotkb:Q96MY6|ensembl:ENSP00000380122 intact:EBI-1200391|uniprotkb:Q9WV99|uniprotkb:Q9WVA0|uniprotkb:Q9Y5J8|uniprotkb:A8K136|ensembl:ENSP00000257245|ensembl:ENSP00000433627|ensembl:ENSP00000435678 psi-mi:mia40_human(display_long)|uniprotkb:MIA40(gene name synonym)|uniprotkb:Coiled-coil-helix-coiled-coil-helix domain-containing protein 4(gene name synonym)|uniprotkb:CHCHD4(gene name)|psi-mi:CHCHD4(display_short) psi-mi:tim10_human(display_long)|uniprotkb:TIMM10(gene name)|psi-mi:TIMM10(display_short)|uniprotkb:TIM10(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Petrungaro et al. (2015) pubmed:26387864|imex:IM-28311 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-25744959|imex:IM-28311-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091972.1|refseq:NP_653237.1|ensembl:ENSG00000163528(gene)|ensembl:ENST00000396914(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0018171"(peptidyl-cysteine oxidation)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0045041"(protein import into mitochondrial intermembrane space)|go:"GO:0051084"('de novo' posttranslational protein folding)|interpro:IPR010625(CHCH)|interpro:IPR039289|mint:Q8N4Q1|rcsb pdb:2K3J|rcsb pdb:2L0Y|reactome:R-HSA-1268020|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|dip:DIP-48483N refseq:NP_036588.1|ensembl:ENSG00000134809(gene)|ensembl:ENST00000257245(transcript)|ensembl:ENST00000525158(transcript)|ensembl:ENST00000525587(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005744"(TIM23 mitochondrial import inner membrane translocase complex)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0008270"(zinc ion binding)|go:"GO:0032977"(membrane insertase activity)|go:"GO:0042719"(mitochondrial intermembrane space protein transporter complex)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045039"(protein insertion into mitochondrial inner membrane)|go:"GO:0051087"(chaperone binding)|interpro:IPR004217(Zinc finger, Tim10/DDP-type)|interpro:IPR027100|interpro:IPR035427|rcsb pdb:2BSK|rcsb pdb:7CGP|reactome:R-HSA-1268020|go:"GO:0007605"(sensory perception of sound) - - - comment:CHCHD2/9 also identified but could not be resolved to a single gene product|figure legend:Figure 1D;Tables S1,S2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens) - 2020/06/30 2020/07/01 rogid:ACH8CTQRjTwq7nz6toGTrn3VHlE9606 rogid:8Ygf3Hjx342xU28Mggg7oTD6hAQ9606 rigid:WRjTrDbZBbp3IZSUoz6Q510SmHc false strep tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N4Q1 uniprotkb:O60220 intact:EBI-2562213|uniprotkb:A8K3Z9|uniprotkb:Q96AI2|uniprotkb:Q96MY6|ensembl:ENSP00000380122 intact:EBI-1049822|uniprotkb:Q6IRW6|uniprotkb:B2R5A6|ensembl:ENSP00000361993 psi-mi:mia40_human(display_long)|uniprotkb:MIA40(gene name synonym)|uniprotkb:Coiled-coil-helix-coiled-coil-helix domain-containing protein 4(gene name synonym)|uniprotkb:CHCHD4(gene name)|psi-mi:CHCHD4(display_short) psi-mi:tim8a_human(display_long)|uniprotkb:Deafness dystonia protein 1(gene name synonym)|uniprotkb:X-linked deafness dystonia protein(gene name synonym)|uniprotkb:TIMM8A(gene name)|psi-mi:TIMM8A(display_short)|uniprotkb:DDP(gene name synonym)|uniprotkb:DDP1(gene name synonym)|uniprotkb:TIM8A(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Petrungaro et al. (2015) pubmed:26387864|imex:IM-28311 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-25744959|imex:IM-28311-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091972.1|refseq:NP_653237.1|ensembl:ENSG00000163528(gene)|ensembl:ENST00000396914(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0018171"(peptidyl-cysteine oxidation)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0045041"(protein import into mitochondrial intermembrane space)|go:"GO:0051084"('de novo' posttranslational protein folding)|interpro:IPR010625(CHCH)|interpro:IPR039289|mint:Q8N4Q1|rcsb pdb:2K3J|rcsb pdb:2L0Y|reactome:R-HSA-1268020|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|dip:DIP-48483N refseq:NP_004076.1|reactome:R-HSA-1268020|ensembl:ENSG00000126953(gene)|ensembl:ENST00000372902(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0007399"(nervous system development)|go:"GO:0042802"(identical protein binding)|go:"GO:0045039"(protein insertion into mitochondrial inner membrane)|go:"GO:0046872"(metal ion binding)|interpro:IPR004217(Zinc finger, Tim10/DDP-type)|interpro:IPR035427|interpro:IPR039238|mint:O60220 - - - comment:CHCHD2/9 also identified but could not be resolved to a single gene product|figure legend:Figure 1D;Tables S1,S2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens) - 2020/06/30 2020/07/01 rogid:ACH8CTQRjTwq7nz6toGTrn3VHlE9606 rogid:v01DxxXFU24eNjL3zVBvqQP9zA49606 rigid:WRjTrDbZBbp3IZSUoz6Q510SmHc false strep tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N4Q1 uniprotkb:Q96HS1 intact:EBI-2562213|uniprotkb:A8K3Z9|uniprotkb:Q96AI2|uniprotkb:Q96MY6|ensembl:ENSP00000380122 intact:EBI-713608|uniprotkb:Q96JB0|intact:EBI-2555528|ensembl:ENSP00000438465|uniprotkb:C9IZY7|uniprotkb:A9LN06 psi-mi:mia40_human(display_long)|uniprotkb:MIA40(gene name synonym)|uniprotkb:Coiled-coil-helix-coiled-coil-helix domain-containing protein 4(gene name synonym)|uniprotkb:CHCHD4(gene name)|psi-mi:CHCHD4(display_short) psi-mi:pgam5_human(display_long)|uniprotkb:Bcl-XL-binding protein v68(gene name synonym)|uniprotkb:PGAM5(gene name)|psi-mi:PGAM5(display_short)|uniprotkb:Phosphoglycerate mutase family member 5(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Petrungaro et al. (2015) pubmed:26387864|imex:IM-28311 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-25744959|imex:IM-28311-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091972.1|refseq:NP_653237.1|ensembl:ENSG00000163528(gene)|ensembl:ENST00000396914(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0018171"(peptidyl-cysteine oxidation)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0045041"(protein import into mitochondrial intermembrane space)|go:"GO:0051084"('de novo' posttranslational protein folding)|interpro:IPR010625(CHCH)|interpro:IPR039289|mint:Q8N4Q1|rcsb pdb:2K3J|rcsb pdb:2L0Y|reactome:R-HSA-1268020|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|dip:DIP-48483N refseq:NP_001164014.1|refseq:NP_612642.2|ensembl:ENSG00000247077(gene)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0016791"(phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0070266"(necroptotic process)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|interpro:IPR013078(Phosphoglycerate mutase)|interpro:IPR029033|mint:Q96HS1|rcsb pdb:3MXO|rcsb pdb:3O0T|rcsb pdb:5MUF|rcsb pdb:6CNI|rcsb pdb:6CNL|reactome:R-HSA-8934903|ensembl:ENST00000498926(transcript)|dip:DIP-50735N - - - comment:CHCHD2/9 also identified but could not be resolved to a single gene product|figure legend:Figure 1D;Tables S1,S2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens) - 2020/06/30 2020/07/01 rogid:ACH8CTQRjTwq7nz6toGTrn3VHlE9606 rogid:prE0I+tNIEjN9Y1NBZbh51DY2+Q9606 rigid:WRjTrDbZBbp3IZSUoz6Q510SmHc false strep tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N4Q1 uniprotkb:O00165 intact:EBI-2562213|uniprotkb:A8K3Z9|uniprotkb:Q96AI2|uniprotkb:Q96MY6|ensembl:ENSP00000380122 intact:EBI-357001|uniprotkb:A8W4W9|uniprotkb:A8W4X0|uniprotkb:B4DUJ7|uniprotkb:Q5VYD7|uniprotkb:Q5VYD5|uniprotkb:Q96AU4|uniprotkb:Q9BS80|ensembl:ENSP00000329002 psi-mi:mia40_human(display_long)|uniprotkb:MIA40(gene name synonym)|uniprotkb:Coiled-coil-helix-coiled-coil-helix domain-containing protein 4(gene name synonym)|uniprotkb:CHCHD4(gene name)|psi-mi:CHCHD4(display_short) psi-mi:hax1_human(display_long)|uniprotkb:HAX1(gene name)|psi-mi:HAX1(display_short)|uniprotkb:HS1BP1(gene name synonym)|uniprotkb:HS1-associating protein X-1(gene name synonym)|uniprotkb:HS1-binding protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Petrungaro et al. (2015) pubmed:26387864|imex:IM-28311 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-25744959|imex:IM-28311-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091972.1|refseq:NP_653237.1|ensembl:ENSG00000163528(gene)|ensembl:ENST00000396914(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0018171"(peptidyl-cysteine oxidation)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0045041"(protein import into mitochondrial intermembrane space)|go:"GO:0051084"('de novo' posttranslational protein folding)|interpro:IPR010625(CHCH)|interpro:IPR039289|mint:Q8N4Q1|rcsb pdb:2K3J|rcsb pdb:2L0Y|reactome:R-HSA-1268020|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|dip:DIP-48483N refseq:NP_001018238.1|refseq:NP_006109.2|dip:DIP-36771N|ensembl:ENSG00000143575(gene)|ensembl:ENST00000328703(transcript)|go:"GO:0000932"(P-body)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005938"(cell cortex)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019966"(interleukin-1 binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR017248(HS1-associating, X-1)|mint:O00165 - - - comment:CHCHD2/9 also identified but could not be resolved to a single gene product|figure legend:Figure 1D;Tables S1,S2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens) - 2020/06/30 2020/07/01 rogid:ACH8CTQRjTwq7nz6toGTrn3VHlE9606 rogid:XRyEPYge2cQFiWdmOaiNIAxd1yQ9606 rigid:WRjTrDbZBbp3IZSUoz6Q510SmHc false strep tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N4Q1 uniprotkb:P55008 intact:EBI-2562213|uniprotkb:A8K3Z9|uniprotkb:Q96AI2|uniprotkb:Q96MY6|ensembl:ENSP00000380122 intact:EBI-9031341|uniprotkb:A8K406|uniprotkb:O43904|uniprotkb:Q9UIV4|uniprotkb:Q9UKS9|ensembl:ENSP00000365227|ensembl:ENSP00000372966|ensembl:ENSP00000391720|ensembl:ENSP00000397842|ensembl:ENSP00000398013|ensembl:ENSP00000416061 psi-mi:mia40_human(display_long)|uniprotkb:MIA40(gene name synonym)|uniprotkb:Coiled-coil-helix-coiled-coil-helix domain-containing protein 4(gene name synonym)|uniprotkb:CHCHD4(gene name)|psi-mi:CHCHD4(display_short) psi-mi:aif1_human(display_long)|uniprotkb:AIF1(gene name)|psi-mi:AIF1(display_short)|uniprotkb:G1(gene name synonym)|uniprotkb:IBA1(gene name synonym)|uniprotkb:Ionized calcium-binding adapter molecule 1(gene name synonym)|uniprotkb:Protein G1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Petrungaro et al. (2015) pubmed:26387864|imex:IM-28311 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-25744959|imex:IM-28311-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091972.1|refseq:NP_653237.1|ensembl:ENSG00000163528(gene)|ensembl:ENST00000396914(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0018171"(peptidyl-cysteine oxidation)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0045041"(protein import into mitochondrial intermembrane space)|go:"GO:0051084"('de novo' posttranslational protein folding)|interpro:IPR010625(CHCH)|interpro:IPR039289|mint:Q8N4Q1|rcsb pdb:2K3J|rcsb pdb:2L0Y|reactome:R-HSA-1268020|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|dip:DIP-48483N refseq:NP_001305899.1|refseq:XP_016865821.1|refseq:NP_001614.3|refseq:NP_116573.1|ensembl:ENSG00000204472(gene)|ensembl:ENSG00000206428(gene)|ensembl:ENSG00000234836(gene)|ensembl:ENSG00000235588(gene)|ensembl:ENSG00000235985(gene)|ensembl:ENSG00000237727(gene)|ensembl:ENST00000376059(transcript)|ensembl:ENST00000383474(transcript)|ensembl:ENST00000413349(transcript)|ensembl:ENST00000414149(transcript)|ensembl:ENST00000425748(transcript)|ensembl:ENST00000440907(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006954"(inflammatory response)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014739"(positive regulation of muscle hyperplasia)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0021549"(cerebellum development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030046"(parallel actin filament bundle assembly)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043204"(perikaryon)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048678"(response to axon injury)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0051764"(actin crosslink formation)|go:"GO:0071315"(cellular response to morphine)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071447"(cellular response to hydroperoxide)|go:"GO:0071672"(negative regulation of smooth muscle cell chemotaxis)|go:"GO:0071677"(positive regulation of mononuclear cell migration)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090271"(positive regulation of fibroblast growth factor production)|go:"GO:0097178"(ruffle assembly)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR042433|rcsb pdb:2D58|rcsb pdb:2G2B|go:"GO:0071673"(positive regulation of smooth muscle cell chemotaxis) - - - comment:CHCHD2/9 also identified but could not be resolved to a single gene product|figure legend:Figure 1D;Tables S1,S2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens) - 2020/06/30 2020/07/01 rogid:ACH8CTQRjTwq7nz6toGTrn3VHlE9606 rogid:rKN2fpMIkINxzNg3lR1zGwxT7Eg9606 rigid:WRjTrDbZBbp3IZSUoz6Q510SmHc false strep tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N4Q1 uniprotkb:Q02952 intact:EBI-2562213|uniprotkb:A8K3Z9|uniprotkb:Q96AI2|uniprotkb:Q96MY6|ensembl:ENSP00000380122 intact:EBI-2562430|intact:EBI-2680946|uniprotkb:O00310|uniprotkb:O00498|uniprotkb:Q4LE68|uniprotkb:Q5SZ80|uniprotkb:Q5TGN1|uniprotkb:Q68D82|uniprotkb:Q99970|ensembl:ENSP00000253332|ensembl:ENSP00000384537 psi-mi:mia40_human(display_long)|uniprotkb:MIA40(gene name synonym)|uniprotkb:Coiled-coil-helix-coiled-coil-helix domain-containing protein 4(gene name synonym)|uniprotkb:CHCHD4(gene name)|psi-mi:CHCHD4(display_short) psi-mi:aka12_human(display_long)|uniprotkb:AKAP12(gene name)|psi-mi:AKAP12(display_short)|uniprotkb:AKAP250(gene name synonym)|uniprotkb:A-kinase anchor protein 250 kDa(gene name synonym)|uniprotkb:Gravin(gene name synonym)|uniprotkb:Myasthenia gravis autoantigen(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Petrungaro et al. (2015) pubmed:26387864|imex:IM-28311 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-25744959|imex:IM-28311-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091972.1|refseq:NP_653237.1|ensembl:ENSG00000163528(gene)|ensembl:ENST00000396914(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0018171"(peptidyl-cysteine oxidation)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0045041"(protein import into mitochondrial intermembrane space)|go:"GO:0051084"('de novo' posttranslational protein folding)|interpro:IPR010625(CHCH)|interpro:IPR039289|mint:Q8N4Q1|rcsb pdb:2K3J|rcsb pdb:2L0Y|reactome:R-HSA-1268020|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|dip:DIP-48483N refseq:NP_005091.2|refseq:NP_653080.1|ensembl:ENSG00000131016(gene)|ensembl:ENST00000253332(transcript)|ensembl:ENST00000402676(transcript)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010739"(positive regulation of protein kinase A signaling)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035733"(hepatic stellate cell activation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0061870"(positive regulation of hepatic stellate cell migration)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090036"(regulation of protein kinase C signaling)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:1900143"(positive regulation of oligodendrocyte apoptotic process)|interpro:IPR001573(Protein kinase A anchoring region)|interpro:IPR018459|interpro:IPR028540|mint:Q02952|reactome:R-HSA-9013405|reactome:R-HSA-9035034|refseq:XP_005267292.1|refseq:XP_016867006.1 - - - comment:CHCHD2/9 also identified but could not be resolved to a single gene product|figure legend:Figure 1D;Tables S1,S2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens) - 2020/06/30 2020/07/01 rogid:ACH8CTQRjTwq7nz6toGTrn3VHlE9606 rogid:vx4mziqb4PDChwfwSzb7mPrCn4w9606 rigid:WRjTrDbZBbp3IZSUoz6Q510SmHc false strep tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N4Q1 uniprotkb:P54819 intact:EBI-2562213|uniprotkb:A8K3Z9|uniprotkb:Q96AI2|uniprotkb:Q96MY6|ensembl:ENSP00000380122 intact:EBI-1056291|uniprotkb:Q16856|uniprotkb:Q5TIF7|uniprotkb:Q8TCY2|uniprotkb:Q8TCY3|uniprotkb:A8K6L1|uniprotkb:B4DHH7|uniprotkb:B4DL64|uniprotkb:Q5EB54|ensembl:ENSP00000499935 psi-mi:mia40_human(display_long)|uniprotkb:MIA40(gene name synonym)|uniprotkb:Coiled-coil-helix-coiled-coil-helix domain-containing protein 4(gene name synonym)|uniprotkb:CHCHD4(gene name)|psi-mi:CHCHD4(display_short) psi-mi:kad2_human(display_long)|uniprotkb:AK2(gene name)|psi-mi:AK2(display_short)|uniprotkb:ADK2(gene name synonym)|uniprotkb:ATP-AMP transphosphorylase 2(gene name synonym)|uniprotkb:"ATP:AMP phosphotransferase"(gene name synonym)|uniprotkb:Adenylate monophosphate kinase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Petrungaro et al. (2015) pubmed:26387864|imex:IM-28311 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-25744959|imex:IM-28311-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091972.1|refseq:NP_653237.1|ensembl:ENSG00000163528(gene)|ensembl:ENST00000396914(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0018171"(peptidyl-cysteine oxidation)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0045041"(protein import into mitochondrial intermembrane space)|go:"GO:0051084"('de novo' posttranslational protein folding)|interpro:IPR010625(CHCH)|interpro:IPR039289|mint:Q8N4Q1|rcsb pdb:2K3J|rcsb pdb:2L0Y|reactome:R-HSA-1268020|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|dip:DIP-48483N refseq:NP_001186128.1|refseq:NP_001616.1|refseq:NP_037543.1|refseq:NP_001306068.1|refseq:NP_001306069.1|ensembl:ENSG00000004455(gene)|ensembl:ENST00000672715(transcript)|go:"GO:0004017"(adenylate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006172"(ADP biosynthetic process)|go:"GO:0015949"(nucleobase-containing small molecule interconversion)|go:"GO:0046033"(AMP metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097226"(sperm mitochondrial sheath)|interpro:IPR000850(Adenylate kinase)|interpro:IPR006259(Adenylate kinase, subfamily)|interpro:IPR007862(Adenylate kinase, zinc-finger lid region)|interpro:IPR027417|interpro:IPR028587|interpro:IPR033690|mint:P54819|rcsb pdb:2C9Y|reactome:R-HSA-499943 - - - comment:CHCHD2/9 also identified but could not be resolved to a single gene product|figure legend:Figure 1D;Tables S1,S2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens) - 2020/06/30 2020/07/01 rogid:ACH8CTQRjTwq7nz6toGTrn3VHlE9606 rogid:pzIKBBzoytYPw3r87WMBueRNpWw9606 rigid:WRjTrDbZBbp3IZSUoz6Q510SmHc false strep tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N4Q1 uniprotkb:P63267 intact:EBI-2562213|uniprotkb:A8K3Z9|uniprotkb:Q96AI2|uniprotkb:Q96MY6|ensembl:ENSP00000380122 intact:EBI-297795|uniprotkb:P12718|uniprotkb:Q504R1|uniprotkb:Q6FI22|ensembl:ENSP00000295137|ensembl:ENSP00000386857|uniprotkb:B2R7E7|uniprotkb:D6W5H8|uniprotkb:B4E315|uniprotkb:E9PG30 psi-mi:mia40_human(display_long)|uniprotkb:MIA40(gene name synonym)|uniprotkb:Coiled-coil-helix-coiled-coil-helix domain-containing protein 4(gene name synonym)|uniprotkb:CHCHD4(gene name)|psi-mi:CHCHD4(display_short) psi-mi:acth_human(display_long)|uniprotkb:ACTG2(gene name)|psi-mi:ACTG2(display_short)|uniprotkb:ACTA3(gene name synonym)|uniprotkb:ACTSG(gene name synonym)|uniprotkb:Smooth muscle gamma-actin(gene name synonym)|uniprotkb:Gamma-2-actin(gene name synonym)|uniprotkb:Alpha-actin-3(gene name synonym)|uniprotkb:ACTL3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Petrungaro et al. (2015) pubmed:26387864|imex:IM-28311 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-25744959|imex:IM-28311-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091972.1|refseq:NP_653237.1|ensembl:ENSG00000163528(gene)|ensembl:ENST00000396914(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0018171"(peptidyl-cysteine oxidation)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0045041"(protein import into mitochondrial intermembrane space)|go:"GO:0051084"('de novo' posttranslational protein folding)|interpro:IPR010625(CHCH)|interpro:IPR039289|mint:Q8N4Q1|rcsb pdb:2K3J|rcsb pdb:2L0Y|reactome:R-HSA-1268020|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|dip:DIP-48483N go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0032982"(myosin filament)|go:"GO:0044297"(cell body)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071944"(cell periphery)|go:"GO:0072562"(blood microparticle)|go:"GO:0090131"(mesenchyme migration)|interpro:IPR004000(Actin/actin-like)|interpro:IPR004001(Actin, conserved site)|interpro:IPR020902|interpro:IPR043129|rcsb pdb:6JAT|reactome:R-HSA-445355|go:"GO:0010628"(positive regulation of gene expression)|ensembl:ENST00000345517(transcript)|ensembl:ENST00000409624(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005869"(dynactin complex)|ensembl:ENSG00000163017(gene)|refseq:NP_001186822.1|refseq:NP_001606.1 - - - comment:CHCHD2/9 also identified but could not be resolved to a single gene product|figure legend:Figure 1D;Tables S1,S2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens) - 2020/06/30 2020/07/01 rogid:ACH8CTQRjTwq7nz6toGTrn3VHlE9606 rogid:tp0JsXhrGsRl5i4Wg2dyaPGUPxA9606 rigid:WRjTrDbZBbp3IZSUoz6Q510SmHc false strep tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N4Q1 uniprotkb:Q9BPX6 intact:EBI-2562213|uniprotkb:A8K3Z9|uniprotkb:Q96AI2|uniprotkb:Q96MY6|ensembl:ENSP00000380122 intact:EBI-2371996|uniprotkb:O75785|uniprotkb:Q9H9N6|uniprotkb:Q9UFX0|uniprotkb:A8MV96|uniprotkb:B3KN20|uniprotkb:B4DJH9|uniprotkb:B4DPI1|uniprotkb:B5MBY3|uniprotkb:D3YTJ3|ensembl:ENSP00000354415 psi-mi:mia40_human(display_long)|uniprotkb:MIA40(gene name synonym)|uniprotkb:Coiled-coil-helix-coiled-coil-helix domain-containing protein 4(gene name synonym)|uniprotkb:CHCHD4(gene name)|psi-mi:CHCHD4(display_short) psi-mi:micu1_human(display_long)|uniprotkb:MICU1(gene name)|psi-mi:MICU1(display_short)|uniprotkb:Calcium-binding atopy-related autoantigen 1(gene name synonym)|uniprotkb:CBARA1(gene name synonym)|uniprotkb:CALC(gene name synonym)|uniprotkb:Atopy-related autoantigen CALC(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Petrungaro et al. (2015) pubmed:26387864|imex:IM-28311 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-25744959|imex:IM-28311-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091972.1|refseq:NP_653237.1|ensembl:ENSG00000163528(gene)|ensembl:ENST00000396914(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0018171"(peptidyl-cysteine oxidation)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0045041"(protein import into mitochondrial intermembrane space)|go:"GO:0051084"('de novo' posttranslational protein folding)|interpro:IPR010625(CHCH)|interpro:IPR039289|mint:Q8N4Q1|rcsb pdb:2K3J|rcsb pdb:2L0Y|reactome:R-HSA-1268020|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|dip:DIP-48483N refseq:NP_001182447.1|refseq:NP_001182448.1|refseq:NP_006068.2|dip:DIP-53438N|ensembl:ENSG00000107745(gene)|ensembl:ENST00000361114(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005622"(intracellular anatomical structure)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0006952"(defense response)|go:"GO:0032592"(integral component of mitochondrial membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0042802"(identical protein binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0070509"(calcium ion import)|go:"GO:1900069"(regulation of cellular hyperosmotic salinity response)|go:"GO:1990246"(uniplex complex)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR039800|rcsb pdb:4NSC|rcsb pdb:4NSD|rcsb pdb:6K7Y|rcsb pdb:6LB7|rcsb pdb:6LB8|rcsb pdb:6LE5|rcsb pdb:6WDN|rcsb pdb:6WDO|rcsb pdb:6XJX|rcsb pdb:6XQN|rcsb pdb:6XQO|reactome:R-HSA-8949215|reactome:R-HSA-8949664|rcsb pdb:6XJV - - - comment:CHCHD2/9 also identified but could not be resolved to a single gene product|figure legend:Figure 1D;Tables S1,S2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens) - 2020/06/30 2020/07/01 rogid:ACH8CTQRjTwq7nz6toGTrn3VHlE9606 rogid:ieoktRyh6dR8RvLctKOhbT84qPU9606 rigid:WRjTrDbZBbp3IZSUoz6Q510SmHc false strep tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N4Q1 uniprotkb:O43805 intact:EBI-2562213|uniprotkb:A8K3Z9|uniprotkb:Q96AI2|uniprotkb:Q96MY6|ensembl:ENSP00000380122 intact:EBI-2515299|ensembl:ENSP00000313752|uniprotkb:Q9BVW8|uniprotkb:Q6FG70|uniprotkb:Q5VSG0 psi-mi:mia40_human(display_long)|uniprotkb:MIA40(gene name synonym)|uniprotkb:Coiled-coil-helix-coiled-coil-helix domain-containing protein 4(gene name synonym)|uniprotkb:CHCHD4(gene name)|psi-mi:CHCHD4(display_short) psi-mi:ssna1_human(display_long)|uniprotkb:SSNA1(gene name)|psi-mi:SSNA1(display_short)|uniprotkb:NA14(gene name synonym)|uniprotkb:Nuclear autoantigen of 14 kDa(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Petrungaro et al. (2015) pubmed:26387864|imex:IM-28311 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-25744959|imex:IM-28311-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091972.1|refseq:NP_653237.1|ensembl:ENSG00000163528(gene)|ensembl:ENST00000396914(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0018171"(peptidyl-cysteine oxidation)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0045041"(protein import into mitochondrial intermembrane space)|go:"GO:0051084"('de novo' posttranslational protein folding)|interpro:IPR010625(CHCH)|interpro:IPR039289|mint:Q8N4Q1|rcsb pdb:2K3J|rcsb pdb:2L0Y|reactome:R-HSA-1268020|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|dip:DIP-48483N ensembl:ENSG00000176101(gene)|ensembl:ENST00000322310(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042073"(intraciliary transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0060830"(ciliary receptor clustering involved in smoothened signaling pathway)|interpro:IPR033362|mint:O43805|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-8854518|refseq:NP_003722.2 - - - comment:CHCHD2/9 also identified but could not be resolved to a single gene product|figure legend:Figure 1D;Tables S1,S2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens) - 2020/06/30 2020/07/01 rogid:ACH8CTQRjTwq7nz6toGTrn3VHlE9606 rogid:W48R8M8go89X1aS1L1AHejuOO+g9606 rigid:WRjTrDbZBbp3IZSUoz6Q510SmHc false strep tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N4Q1 uniprotkb:O96000 intact:EBI-2562213|uniprotkb:A8K3Z9|uniprotkb:Q96AI2|uniprotkb:Q96MY6|ensembl:ENSP00000380122 intact:EBI-1246371|uniprotkb:Q96II6|ensembl:ENSP00000268668 psi-mi:mia40_human(display_long)|uniprotkb:MIA40(gene name synonym)|uniprotkb:Coiled-coil-helix-coiled-coil-helix domain-containing protein 4(gene name synonym)|uniprotkb:CHCHD4(gene name)|psi-mi:CHCHD4(display_short) psi-mi:nduba_human(display_long)|uniprotkb:NDUFB10(gene name)|psi-mi:NDUFB10(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase PDSW subunit(gene name synonym)|uniprotkb:Complex I-PDSW(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Petrungaro et al. (2015) pubmed:26387864|imex:IM-28311 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-25744959|imex:IM-28311-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091972.1|refseq:NP_653237.1|ensembl:ENSG00000163528(gene)|ensembl:ENST00000396914(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0018171"(peptidyl-cysteine oxidation)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0045041"(protein import into mitochondrial intermembrane space)|go:"GO:0051084"('de novo' posttranslational protein folding)|interpro:IPR010625(CHCH)|interpro:IPR039289|mint:Q8N4Q1|rcsb pdb:2K3J|rcsb pdb:2L0Y|reactome:R-HSA-1268020|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|dip:DIP-48483N refseq:NP_004539.1|ensembl:ENSG00000140990(gene)|ensembl:ENST00000268668(transcript)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|interpro:IPR019377|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR039993|rcsb pdb:5XTC|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198|dip:DIP-38298N - - - comment:CHCHD2/9 also identified but could not be resolved to a single gene product|figure legend:Figure 1D;Tables S1,S2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens) - 2020/06/30 2020/07/01 rogid:ACH8CTQRjTwq7nz6toGTrn3VHlE9606 rogid:CRQJLj/I1jZSnIU7GeuRDGN4hRA9606 rigid:WRjTrDbZBbp3IZSUoz6Q510SmHc false strep tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N4Q1 uniprotkb:Q9NX70 intact:EBI-2562213|uniprotkb:A8K3Z9|uniprotkb:Q96AI2|uniprotkb:Q96MY6|ensembl:ENSP00000380122 intact:EBI-394656|uniprotkb:Q9NTF4|uniprotkb:Q5XX09|uniprotkb:B4DNQ6|uniprotkb:M0R2E4|ensembl:ENSP00000314343 psi-mi:mia40_human(display_long)|uniprotkb:MIA40(gene name synonym)|uniprotkb:Coiled-coil-helix-coiled-coil-helix domain-containing protein 4(gene name synonym)|uniprotkb:CHCHD4(gene name)|psi-mi:CHCHD4(display_short) psi-mi:med29_human(display_long)|uniprotkb:MED29(gene name)|psi-mi:MED29(display_short)|uniprotkb:Mediator complex subunit 29(gene name synonym)|uniprotkb:Intersex-like protein(gene name synonym)|uniprotkb:IXL(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Petrungaro et al. (2015) pubmed:26387864|imex:IM-28311 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-25744959|imex:IM-28311-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091972.1|refseq:NP_653237.1|ensembl:ENSG00000163528(gene)|ensembl:ENST00000396914(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0018171"(peptidyl-cysteine oxidation)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0045041"(protein import into mitochondrial intermembrane space)|go:"GO:0051084"('de novo' posttranslational protein folding)|interpro:IPR010625(CHCH)|interpro:IPR039289|mint:Q8N4Q1|rcsb pdb:2K3J|rcsb pdb:2L0Y|reactome:R-HSA-1268020|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|dip:DIP-48483N refseq:NP_060062.1|refseq:NP_001304699.1|ensembl:ENSG00000063322(gene)|ensembl:ENST00000315588(transcript)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016592"(mediator complex)|interpro:IPR021018|mint:Q9NX70|rcsb pdb:7EMF|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7ENJ|rcsb pdb:7LBM|reactome:R-HSA-1989781|reactome:R-HSA-381340 - - - comment:CHCHD2/9 also identified but could not be resolved to a single gene product|figure legend:Figure 1D;Tables S1,S2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens) - 2020/06/30 2020/07/01 rogid:ACH8CTQRjTwq7nz6toGTrn3VHlE9606 rogid:WOrt3DAoOape6p0CwWSLIW55hVg9606 rigid:WRjTrDbZBbp3IZSUoz6Q510SmHc false strep tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N4Q1 uniprotkb:Q8IWC1 intact:EBI-2562213|uniprotkb:A8K3Z9|uniprotkb:Q96AI2|uniprotkb:Q96MY6|ensembl:ENSP00000380122 intact:EBI-1050284|uniprotkb:A6NCZ7|uniprotkb:A2A2J0|uniprotkb:A6NHR4|uniprotkb:Q5JXI5|uniprotkb:Q5JXI6|uniprotkb:Q9H9M8|uniprotkb:Q6P2S1|uniprotkb:B4DWD2|uniprotkb:H7BY77|ensembl:ENSP00000318086 psi-mi:mia40_human(display_long)|uniprotkb:MIA40(gene name synonym)|uniprotkb:Coiled-coil-helix-coiled-coil-helix domain-containing protein 4(gene name synonym)|uniprotkb:CHCHD4(gene name)|psi-mi:CHCHD4(display_short) psi-mi:ma7d3_human(display_long)|uniprotkb:MAP7D3(gene name)|psi-mi:MAP7D3(display_short)|uniprotkb:MDP3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Petrungaro et al. (2015) pubmed:26387864|imex:IM-28311 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-25744959|imex:IM-28311-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091972.1|refseq:NP_653237.1|ensembl:ENSG00000163528(gene)|ensembl:ENST00000396914(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0018171"(peptidyl-cysteine oxidation)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0045041"(protein import into mitochondrial intermembrane space)|go:"GO:0051084"('de novo' posttranslational protein folding)|interpro:IPR010625(CHCH)|interpro:IPR039289|mint:Q8N4Q1|rcsb pdb:2K3J|rcsb pdb:2L0Y|reactome:R-HSA-1268020|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|dip:DIP-48483N refseq:NP_001166987.1|refseq:NP_001166988.1|refseq:NP_078873.2|ensembl:ENSG00000129680(gene)|ensembl:ENST00000316077(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0008017"(microtubule binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0015631"(tubulin binding)|go:"GO:0016020"(membrane)|go:"GO:0046785"(microtubule polymerization)|interpro:IPR008604(E-MAP-115) - - - comment:CHCHD2/9 also identified but could not be resolved to a single gene product|figure legend:Figure 1D;Tables S1,S2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens) - 2020/06/30 2020/07/01 rogid:ACH8CTQRjTwq7nz6toGTrn3VHlE9606 rogid:9WwXvs5DT9zh5c7DC27VuemEeU09606 rigid:WRjTrDbZBbp3IZSUoz6Q510SmHc false strep tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N4Q1 uniprotkb:Q4VC31 intact:EBI-2562213|uniprotkb:A8K3Z9|uniprotkb:Q96AI2|uniprotkb:Q96MY6|ensembl:ENSP00000380122 intact:EBI-1051617|uniprotkb:Q32LY6|ensembl:ENSP00000291458 psi-mi:mia40_human(display_long)|uniprotkb:MIA40(gene name synonym)|uniprotkb:Coiled-coil-helix-coiled-coil-helix domain-containing protein 4(gene name synonym)|uniprotkb:CHCHD4(gene name)|psi-mi:CHCHD4(display_short) psi-mi:mix23_human(display_long)|uniprotkb:MIX23(gene name)|psi-mi:MIX23(display_short)|uniprotkb:CCDC58(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 58(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Petrungaro et al. (2015) pubmed:26387864|imex:IM-28311 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-25744959|imex:IM-28311-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091972.1|refseq:NP_653237.1|ensembl:ENSG00000163528(gene)|ensembl:ENST00000396914(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0018171"(peptidyl-cysteine oxidation)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0045041"(protein import into mitochondrial intermembrane space)|go:"GO:0051084"('de novo' posttranslational protein folding)|interpro:IPR010625(CHCH)|interpro:IPR039289|mint:Q8N4Q1|rcsb pdb:2K3J|rcsb pdb:2L0Y|reactome:R-HSA-1268020|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|dip:DIP-48483N refseq:NP_001017928.1|refseq:NP_001295255.1|ensembl:ENSG00000160124(gene)|ensembl:ENST00000291458(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|interpro:IPR019171 - - - comment:CHCHD2/9 also identified but could not be resolved to a single gene product|figure legend:Figure 1D;Tables S1,S2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens) - 2020/06/30 2020/07/01 rogid:ACH8CTQRjTwq7nz6toGTrn3VHlE9606 rogid:gB8FPCT9VG4P1zyieoDNbQbLW2w9606 rigid:WRjTrDbZBbp3IZSUoz6Q510SmHc false strep tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N4Q1 uniprotkb:Q96BR5 intact:EBI-2562213|uniprotkb:A8K3Z9|uniprotkb:Q96AI2|uniprotkb:Q96MY6|ensembl:ENSP00000380122 intact:EBI-6269632|ensembl:ENSP00000360593|uniprotkb:Q0P6I7|uniprotkb:Q9H9Z9 psi-mi:mia40_human(display_long)|uniprotkb:MIA40(gene name synonym)|uniprotkb:Coiled-coil-helix-coiled-coil-helix domain-containing protein 4(gene name synonym)|uniprotkb:CHCHD4(gene name)|psi-mi:CHCHD4(display_short) psi-mi:coa7_human(display_long)|uniprotkb:COA7(gene name)|psi-mi:COA7(display_short)|uniprotkb:Beta-lactamase hcp-like protein(gene name synonym)|uniprotkb:C1orf163(gene name synonym)|uniprotkb:RESA1(gene name synonym)|uniprotkb:Respiratory chain assembly factor 1(gene name synonym)|uniprotkb:SELRC1(gene name synonym)|uniprotkb:Sel1 repeat-containing protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Petrungaro et al. (2015) pubmed:26387864|imex:IM-28311 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-25744959|imex:IM-28311-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091972.1|refseq:NP_653237.1|ensembl:ENSG00000163528(gene)|ensembl:ENST00000396914(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0018171"(peptidyl-cysteine oxidation)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0045041"(protein import into mitochondrial intermembrane space)|go:"GO:0051084"('de novo' posttranslational protein folding)|interpro:IPR010625(CHCH)|interpro:IPR039289|mint:Q8N4Q1|rcsb pdb:2K3J|rcsb pdb:2L0Y|reactome:R-HSA-1268020|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|dip:DIP-48483N ensembl:ENSG00000162377(gene)|ensembl:ENST00000371538(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|interpro:IPR006597(Sel1-like)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR040239|refseq:NP_075565.2 - - - comment:CHCHD2/9 also identified but could not be resolved to a single gene product|figure legend:Figure 1D;Tables S1,S2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens) - 2020/06/30 2020/07/01 rogid:ACH8CTQRjTwq7nz6toGTrn3VHlE9606 rogid:lFzdNRL3Mr9Jhk+/zN6aEyZmfDI9606 rigid:WRjTrDbZBbp3IZSUoz6Q510SmHc false strep tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N4Q1 uniprotkb:Q9Y5L4 intact:EBI-2562213|uniprotkb:A8K3Z9|uniprotkb:Q96AI2|uniprotkb:Q96MY6|ensembl:ENSP00000380122 intact:EBI-1057344|uniprotkb:P62206|uniprotkb:Q9UHL8|uniprotkb:Q9WTL1|ensembl:ENSP00000215570 psi-mi:mia40_human(display_long)|uniprotkb:MIA40(gene name synonym)|uniprotkb:Coiled-coil-helix-coiled-coil-helix domain-containing protein 4(gene name synonym)|uniprotkb:CHCHD4(gene name)|psi-mi:CHCHD4(display_short) psi-mi:tim13_human(display_long)|uniprotkb:TIMM13(gene name)|psi-mi:TIMM13(display_short)|uniprotkb:TIM13B(gene name synonym)|uniprotkb:TIMM13A(gene name synonym)|uniprotkb:TIMM13B(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Petrungaro et al. (2015) pubmed:26387864|imex:IM-28311 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-25744959|imex:IM-28311-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091972.1|refseq:NP_653237.1|ensembl:ENSG00000163528(gene)|ensembl:ENST00000396914(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0018171"(peptidyl-cysteine oxidation)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0045041"(protein import into mitochondrial intermembrane space)|go:"GO:0051084"('de novo' posttranslational protein folding)|interpro:IPR010625(CHCH)|interpro:IPR039289|mint:Q8N4Q1|rcsb pdb:2K3J|rcsb pdb:2L0Y|reactome:R-HSA-1268020|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|dip:DIP-48483N refseq:NP_036590.1|ensembl:ENSG00000099800(gene)|ensembl:ENST00000215570(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008270"(zinc ion binding)|go:"GO:0042719"(mitochondrial intermembrane space protein transporter complex)|go:"GO:0045039"(protein insertion into mitochondrial inner membrane)|interpro:IPR004217(Zinc finger, Tim10/DDP-type)|interpro:IPR035427|interpro:IPR039238|mint:Q9Y5L4|reactome:R-HSA-1268020 - - - comment:CHCHD2/9 also identified but could not be resolved to a single gene product|figure legend:Figure 1D;Tables S1,S2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens) - 2020/06/30 2020/07/01 rogid:ACH8CTQRjTwq7nz6toGTrn3VHlE9606 rogid:kFNYBvKwUM0JECXq9FjvYv55JAM9606 rigid:WRjTrDbZBbp3IZSUoz6Q510SmHc false strep tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N4Q1 uniprotkb:P55789 intact:EBI-2562213|uniprotkb:A8K3Z9|uniprotkb:Q96AI2|uniprotkb:Q96MY6|ensembl:ENSP00000380122 intact:EBI-718281|uniprotkb:Q8TAH6|uniprotkb:Q9H290|uniprotkb:Q9UK40|intact:EBI-6137916|uniprotkb:Q53YM6|ensembl:ENSP00000248114 psi-mi:mia40_human(display_long)|uniprotkb:MIA40(gene name synonym)|uniprotkb:Coiled-coil-helix-coiled-coil-helix domain-containing protein 4(gene name synonym)|uniprotkb:CHCHD4(gene name)|psi-mi:CHCHD4(display_short) psi-mi:alr_human(display_long)|uniprotkb:Augmenter of liver regeneration(gene name synonym)|uniprotkb:GFER(gene name)|psi-mi:GFER(display_short)|uniprotkb:ALR(gene name synonym)|uniprotkb:HERV1(gene name synonym)|uniprotkb:HPO(gene name synonym)|uniprotkb:Hepatopoietin(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Petrungaro et al. (2015) pubmed:26387864|imex:IM-28311 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-25744959|imex:IM-28311-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091972.1|refseq:NP_653237.1|ensembl:ENSG00000163528(gene)|ensembl:ENST00000396914(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0018171"(peptidyl-cysteine oxidation)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0045041"(protein import into mitochondrial intermembrane space)|go:"GO:0051084"('de novo' posttranslational protein folding)|interpro:IPR010625(CHCH)|interpro:IPR039289|mint:Q8N4Q1|rcsb pdb:2K3J|rcsb pdb:2L0Y|reactome:R-HSA-1268020|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|dip:DIP-48483N refseq:NP_005253.3|ensembl:ENSG00000127554(gene)|ensembl:ENST00000248114(transcript)|go:"GO:0001889"(liver development)|go:"GO:0005576"(extracellular region)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0008083"(growth factor activity)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0016971"(flavin-linked sulfhydryl oxidase activity)|go:"GO:0050660"(flavin adenine dinucleotide binding)|interpro:IPR017905|interpro:IPR036774|interpro:IPR039799|rcsb pdb:3MBG|rcsb pdb:3O55|rcsb pdb:3TK0|rcsb pdb:3U2L|rcsb pdb:3U2M|rcsb pdb:3U5S|rcsb pdb:4LDK|reactome:R-HSA-1268020 - - - comment:CHCHD2/9 also identified but could not be resolved to a single gene product|figure legend:Figure 1D;Tables S1,S2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens) - 2020/06/30 2020/07/01 rogid:ACH8CTQRjTwq7nz6toGTrn3VHlE9606 rogid:ttWSaYxpd3WUg61NQC7eiybRFUg9606 rigid:WRjTrDbZBbp3IZSUoz6Q510SmHc false strep tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9BPX6 uniprotkb:Q8N4Q1 intact:EBI-2371996|uniprotkb:O75785|uniprotkb:Q9H9N6|uniprotkb:Q9UFX0|uniprotkb:A8MV96|uniprotkb:B3KN20|uniprotkb:B4DJH9|uniprotkb:B4DPI1|uniprotkb:B5MBY3|uniprotkb:D3YTJ3|ensembl:ENSP00000354415 intact:EBI-2562213|uniprotkb:A8K3Z9|uniprotkb:Q96AI2|uniprotkb:Q96MY6|ensembl:ENSP00000380122 psi-mi:micu1_human(display_long)|uniprotkb:MICU1(gene name)|psi-mi:MICU1(display_short)|uniprotkb:Calcium-binding atopy-related autoantigen 1(gene name synonym)|uniprotkb:CBARA1(gene name synonym)|uniprotkb:CALC(gene name synonym)|uniprotkb:Atopy-related autoantigen CALC(gene name synonym) psi-mi:mia40_human(display_long)|uniprotkb:MIA40(gene name synonym)|uniprotkb:Coiled-coil-helix-coiled-coil-helix domain-containing protein 4(gene name synonym)|uniprotkb:CHCHD4(gene name)|psi-mi:CHCHD4(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Petrungaro et al. (2015) pubmed:26387864|imex:IM-28311 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-25745002|imex:IM-28311-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001182447.1|refseq:NP_001182448.1|refseq:NP_006068.2|dip:DIP-53438N|ensembl:ENSG00000107745(gene)|ensembl:ENST00000361114(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005622"(intracellular anatomical structure)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0006952"(defense response)|go:"GO:0032592"(integral component of mitochondrial membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0042802"(identical protein binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0070509"(calcium ion import)|go:"GO:1900069"(regulation of cellular hyperosmotic salinity response)|go:"GO:1990246"(uniplex complex)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR039800|rcsb pdb:4NSC|rcsb pdb:4NSD|rcsb pdb:6K7Y|rcsb pdb:6LB7|rcsb pdb:6LB8|rcsb pdb:6LE5|rcsb pdb:6WDN|rcsb pdb:6WDO|rcsb pdb:6XJX|rcsb pdb:6XQN|rcsb pdb:6XQO|reactome:R-HSA-8949215|reactome:R-HSA-8949664|rcsb pdb:6XJV refseq:NP_001091972.1|refseq:NP_653237.1|ensembl:ENSG00000163528(gene)|ensembl:ENST00000396914(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0018171"(peptidyl-cysteine oxidation)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0045041"(protein import into mitochondrial intermembrane space)|go:"GO:0051084"('de novo' posttranslational protein folding)|interpro:IPR010625(CHCH)|interpro:IPR039289|mint:Q8N4Q1|rcsb pdb:2K3J|rcsb pdb:2L0Y|reactome:R-HSA-1268020|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|dip:DIP-48483N - - - figure legend:Figure 2A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens) - 2020/06/30 2020/07/01 rogid:ieoktRyh6dR8RvLctKOhbT84qPU9606 rogid:ACH8CTQRjTwq7nz6toGTrn3VHlE9606 rigid:0f5fVmDhEigxKelXfeDnLI017Lg false - mutation with no effect:53-53|mutation disrupting interaction strength:55-55|mutation disrupting interaction strength:55-55,4-4,53-53|strep tag:c-c - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9BPX6 uniprotkb:Q8N4Q1 intact:EBI-2371996|uniprotkb:O75785|uniprotkb:Q9H9N6|uniprotkb:Q9UFX0|uniprotkb:A8MV96|uniprotkb:B3KN20|uniprotkb:B4DJH9|uniprotkb:B4DPI1|uniprotkb:B5MBY3|uniprotkb:D3YTJ3|ensembl:ENSP00000354415 intact:EBI-2562213|uniprotkb:A8K3Z9|uniprotkb:Q96AI2|uniprotkb:Q96MY6|ensembl:ENSP00000380122 psi-mi:micu1_human(display_long)|uniprotkb:MICU1(gene name)|psi-mi:MICU1(display_short)|uniprotkb:Calcium-binding atopy-related autoantigen 1(gene name synonym)|uniprotkb:CBARA1(gene name synonym)|uniprotkb:CALC(gene name synonym)|uniprotkb:Atopy-related autoantigen CALC(gene name synonym) psi-mi:mia40_human(display_long)|uniprotkb:MIA40(gene name synonym)|uniprotkb:Coiled-coil-helix-coiled-coil-helix domain-containing protein 4(gene name synonym)|uniprotkb:CHCHD4(gene name)|psi-mi:CHCHD4(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Petrungaro et al. (2015) pubmed:26387864|imex:IM-28311 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-25745275|imex:IM-28311-13 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001182447.1|refseq:NP_001182448.1|refseq:NP_006068.2|dip:DIP-53438N|ensembl:ENSG00000107745(gene)|ensembl:ENST00000361114(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005622"(intracellular anatomical structure)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0006952"(defense response)|go:"GO:0032592"(integral component of mitochondrial membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0042802"(identical protein binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0070509"(calcium ion import)|go:"GO:1900069"(regulation of cellular hyperosmotic salinity response)|go:"GO:1990246"(uniplex complex)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR039800|rcsb pdb:4NSC|rcsb pdb:4NSD|rcsb pdb:6K7Y|rcsb pdb:6LB7|rcsb pdb:6LB8|rcsb pdb:6LE5|rcsb pdb:6WDN|rcsb pdb:6WDO|rcsb pdb:6XJX|rcsb pdb:6XQN|rcsb pdb:6XQO|reactome:R-HSA-8949215|reactome:R-HSA-8949664|rcsb pdb:6XJV refseq:NP_001091972.1|refseq:NP_653237.1|ensembl:ENSG00000163528(gene)|ensembl:ENST00000396914(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0018171"(peptidyl-cysteine oxidation)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0045041"(protein import into mitochondrial intermembrane space)|go:"GO:0051084"('de novo' posttranslational protein folding)|interpro:IPR010625(CHCH)|interpro:IPR039289|mint:Q8N4Q1|rcsb pdb:2K3J|rcsb pdb:2L0Y|reactome:R-HSA-1268020|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|dip:DIP-48483N - - - figure legend:Figure 3h|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens) - 2020/06/30 2020/07/01 rogid:ieoktRyh6dR8RvLctKOhbT84qPU9606 rogid:ACH8CTQRjTwq7nz6toGTrn3VHlE9606 rigid:0f5fVmDhEigxKelXfeDnLI017Lg false ha tag:c-c|mutation disrupting interaction strength:463-463 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8NE86 uniprotkb:Q8IYU8 intact:EBI-6552124|ensembl:ENSP00000362144|uniprotkb:B2RDF3|uniprotkb:B3KXV7|uniprotkb:Q96FL3 intact:EBI-3197790|ensembl:ENSP00000371811|uniprotkb:Q8N0T6|uniprotkb:Q8NAX8 psi-mi:mcu_human(display_long)|uniprotkb:MCU(gene name)|psi-mi:MCU(display_short)|uniprotkb:C10orf42(gene name synonym)|uniprotkb:CCDC109A(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 109A(gene name synonym) psi-mi:micu2_human(display_long)|uniprotkb:MICU2(gene name)|psi-mi:MICU2(display_short)|uniprotkb:EF-hand domain-containing family member A1(gene name synonym)|uniprotkb:EFHA1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Petrungaro et al. (2015) pubmed:26387864|imex:IM-28311 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-25745458|imex:IM-28311-23 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0034704"(calcium channel complex)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1990246"(uniplex complex)|interpro:IPR006769(Protein of unknown function DUF607)|interpro:IPR039055|rcsb pdb:4XSJ|rcsb pdb:4XTB|rcsb pdb:5BZ6|rcsb pdb:5KUE|rcsb pdb:5KUG|rcsb pdb:5KUI|rcsb pdb:5KUJ|rcsb pdb:6JG0|rcsb pdb:6K7X|rcsb pdb:6K7Y|rcsb pdb:6KVX|rcsb pdb:6O58|rcsb pdb:6O5B|rcsb pdb:6WDN|rcsb pdb:6WDO|rcsb pdb:6XJV|rcsb pdb:6XJX|reactome:R-HSA-8949215|reactome:R-HSA-8949664|go:"GO:0019722"(calcium-mediated signaling)|ensembl:ENSG00000156026(gene)|ensembl:ENST00000373053(transcript)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0015292"(uniporter activity)|refseq:NP_001257608.1|refseq:NP_001257609.1|refseq:NP_612366.1|dip:DIP-60468N ensembl:ENSG00000165487(gene)|ensembl:ENST00000382374(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0034704"(calcium channel complex)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0051562"(negative regulation of mitochondrial calcium ion concentration)|go:"GO:1990246"(uniplex complex)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR039800|rcsb pdb:6AGH|rcsb pdb:6IIH|rcsb pdb:6K7Y|rcsb pdb:6LB7|rcsb pdb:6LB8|rcsb pdb:6LE5|rcsb pdb:6WDN|rcsb pdb:6WDO|rcsb pdb:6XJV|rcsb pdb:6XJX|rcsb pdb:6XQN|rcsb pdb:6XQO|reactome:R-HSA-8949215|reactome:R-HSA-8949664|refseq:NP_689939.1 - - - figure legend:Figure 6E, 6H|comment:The interaction decreased at high Ca2+concentrations|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens) - 2020/06/30 2020/07/01 rogid:t2fSATmrk7IEC0nMpquAoPB3CHs9606 rogid:qj7nAE+DvoW/RWlr4VWGSbhS6Mc9606 rigid:HXMbQmlBBO7pUB5gtCPtIb+Wers false flag tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8NE86 uniprotkb:Q9BPX6 intact:EBI-6552124|ensembl:ENSP00000362144|uniprotkb:B2RDF3|uniprotkb:B3KXV7|uniprotkb:Q96FL3 intact:EBI-2371996|uniprotkb:O75785|uniprotkb:Q9H9N6|uniprotkb:Q9UFX0|uniprotkb:A8MV96|uniprotkb:B3KN20|uniprotkb:B4DJH9|uniprotkb:B4DPI1|uniprotkb:B5MBY3|uniprotkb:D3YTJ3|ensembl:ENSP00000354415 psi-mi:mcu_human(display_long)|uniprotkb:MCU(gene name)|psi-mi:MCU(display_short)|uniprotkb:C10orf42(gene name synonym)|uniprotkb:CCDC109A(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 109A(gene name synonym) psi-mi:micu1_human(display_long)|uniprotkb:MICU1(gene name)|psi-mi:MICU1(display_short)|uniprotkb:Calcium-binding atopy-related autoantigen 1(gene name synonym)|uniprotkb:CBARA1(gene name synonym)|uniprotkb:CALC(gene name synonym)|uniprotkb:Atopy-related autoantigen CALC(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Petrungaro et al. (2015) pubmed:26387864|imex:IM-28311 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-25745458|imex:IM-28311-23 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0034704"(calcium channel complex)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1990246"(uniplex complex)|interpro:IPR006769(Protein of unknown function DUF607)|interpro:IPR039055|rcsb pdb:4XSJ|rcsb pdb:4XTB|rcsb pdb:5BZ6|rcsb pdb:5KUE|rcsb pdb:5KUG|rcsb pdb:5KUI|rcsb pdb:5KUJ|rcsb pdb:6JG0|rcsb pdb:6K7X|rcsb pdb:6K7Y|rcsb pdb:6KVX|rcsb pdb:6O58|rcsb pdb:6O5B|rcsb pdb:6WDN|rcsb pdb:6WDO|rcsb pdb:6XJV|rcsb pdb:6XJX|reactome:R-HSA-8949215|reactome:R-HSA-8949664|go:"GO:0019722"(calcium-mediated signaling)|ensembl:ENSG00000156026(gene)|ensembl:ENST00000373053(transcript)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0015292"(uniporter activity)|refseq:NP_001257608.1|refseq:NP_001257609.1|refseq:NP_612366.1|dip:DIP-60468N refseq:NP_001182447.1|refseq:NP_001182448.1|refseq:NP_006068.2|dip:DIP-53438N|ensembl:ENSG00000107745(gene)|ensembl:ENST00000361114(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005622"(intracellular anatomical structure)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0006952"(defense response)|go:"GO:0032592"(integral component of mitochondrial membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0042802"(identical protein binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0070509"(calcium ion import)|go:"GO:1900069"(regulation of cellular hyperosmotic salinity response)|go:"GO:1990246"(uniplex complex)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR039800|rcsb pdb:4NSC|rcsb pdb:4NSD|rcsb pdb:6K7Y|rcsb pdb:6LB7|rcsb pdb:6LB8|rcsb pdb:6LE5|rcsb pdb:6WDN|rcsb pdb:6WDO|rcsb pdb:6XJX|rcsb pdb:6XQN|rcsb pdb:6XQO|reactome:R-HSA-8949215|reactome:R-HSA-8949664|rcsb pdb:6XJV - - - figure legend:Figure 6E, 6H|comment:The interaction decreased at high Ca2+concentrations|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens) - 2020/06/30 2020/07/01 rogid:t2fSATmrk7IEC0nMpquAoPB3CHs9606 rogid:ieoktRyh6dR8RvLctKOhbT84qPU9606 rigid:HXMbQmlBBO7pUB5gtCPtIb+Wers false flag tag:c-c ha tag:c-c|mutation with no effect:463-463 - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9BPX6 uniprotkb:Q8N4Q1 intact:EBI-2371996|uniprotkb:O75785|uniprotkb:Q9H9N6|uniprotkb:Q9UFX0|uniprotkb:A8MV96|uniprotkb:B3KN20|uniprotkb:B4DJH9|uniprotkb:B4DPI1|uniprotkb:B5MBY3|uniprotkb:D3YTJ3|ensembl:ENSP00000354415 intact:EBI-2562213|uniprotkb:A8K3Z9|uniprotkb:Q96AI2|uniprotkb:Q96MY6|ensembl:ENSP00000380122 psi-mi:micu1_human(display_long)|uniprotkb:MICU1(gene name)|psi-mi:MICU1(display_short)|uniprotkb:Calcium-binding atopy-related autoantigen 1(gene name synonym)|uniprotkb:CBARA1(gene name synonym)|uniprotkb:CALC(gene name synonym)|uniprotkb:Atopy-related autoantigen CALC(gene name synonym) psi-mi:mia40_human(display_long)|uniprotkb:MIA40(gene name synonym)|uniprotkb:Coiled-coil-helix-coiled-coil-helix domain-containing protein 4(gene name synonym)|uniprotkb:CHCHD4(gene name)|psi-mi:CHCHD4(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Petrungaro et al. (2015) pubmed:26387864|imex:IM-28311 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-25745026|imex:IM-28311-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001182447.1|refseq:NP_001182448.1|refseq:NP_006068.2|dip:DIP-53438N|ensembl:ENSG00000107745(gene)|ensembl:ENST00000361114(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005622"(intracellular anatomical structure)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0006952"(defense response)|go:"GO:0032592"(integral component of mitochondrial membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0042802"(identical protein binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0070509"(calcium ion import)|go:"GO:1900069"(regulation of cellular hyperosmotic salinity response)|go:"GO:1990246"(uniplex complex)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR039800|rcsb pdb:4NSC|rcsb pdb:4NSD|rcsb pdb:6K7Y|rcsb pdb:6LB7|rcsb pdb:6LB8|rcsb pdb:6LE5|rcsb pdb:6WDN|rcsb pdb:6WDO|rcsb pdb:6XJX|rcsb pdb:6XQN|rcsb pdb:6XQO|reactome:R-HSA-8949215|reactome:R-HSA-8949664|rcsb pdb:6XJV refseq:NP_001091972.1|refseq:NP_653237.1|ensembl:ENSG00000163528(gene)|ensembl:ENST00000396914(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0018171"(peptidyl-cysteine oxidation)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0045041"(protein import into mitochondrial intermembrane space)|go:"GO:0051084"('de novo' posttranslational protein folding)|interpro:IPR010625(CHCH)|interpro:IPR039289|mint:Q8N4Q1|rcsb pdb:2K3J|rcsb pdb:2L0Y|reactome:R-HSA-1268020|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|dip:DIP-48483N - - - figure legend:Figure 2B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens) - 2020/06/30 2020/07/01 rogid:ieoktRyh6dR8RvLctKOhbT84qPU9606 rogid:ACH8CTQRjTwq7nz6toGTrn3VHlE9606 rigid:0f5fVmDhEigxKelXfeDnLI017Lg false ha tag:c-c strep tag:c-c - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9BPX6 uniprotkb:Q8NE86 intact:EBI-2371996|uniprotkb:O75785|uniprotkb:Q9H9N6|uniprotkb:Q9UFX0|uniprotkb:A8MV96|uniprotkb:B3KN20|uniprotkb:B4DJH9|uniprotkb:B4DPI1|uniprotkb:B5MBY3|uniprotkb:D3YTJ3|ensembl:ENSP00000354415 intact:EBI-6552124|ensembl:ENSP00000362144|uniprotkb:B2RDF3|uniprotkb:B3KXV7|uniprotkb:Q96FL3 psi-mi:micu1_human(display_long)|uniprotkb:MICU1(gene name)|psi-mi:MICU1(display_short)|uniprotkb:Calcium-binding atopy-related autoantigen 1(gene name synonym)|uniprotkb:CBARA1(gene name synonym)|uniprotkb:CALC(gene name synonym)|uniprotkb:Atopy-related autoantigen CALC(gene name synonym) psi-mi:mcu_human(display_long)|uniprotkb:MCU(gene name)|psi-mi:MCU(display_short)|uniprotkb:C10orf42(gene name synonym)|uniprotkb:CCDC109A(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 109A(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Petrungaro et al. (2015) pubmed:26387864|imex:IM-28311 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-25745303|imex:IM-28311-15 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001182447.1|refseq:NP_001182448.1|refseq:NP_006068.2|dip:DIP-53438N|ensembl:ENSG00000107745(gene)|ensembl:ENST00000361114(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005622"(intracellular anatomical structure)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0006952"(defense response)|go:"GO:0032592"(integral component of mitochondrial membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0042802"(identical protein binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0070509"(calcium ion import)|go:"GO:1900069"(regulation of cellular hyperosmotic salinity response)|go:"GO:1990246"(uniplex complex)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR039800|rcsb pdb:4NSC|rcsb pdb:4NSD|rcsb pdb:6K7Y|rcsb pdb:6LB7|rcsb pdb:6LB8|rcsb pdb:6LE5|rcsb pdb:6WDN|rcsb pdb:6WDO|rcsb pdb:6XJX|rcsb pdb:6XQN|rcsb pdb:6XQO|reactome:R-HSA-8949215|reactome:R-HSA-8949664|rcsb pdb:6XJV go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0034704"(calcium channel complex)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1990246"(uniplex complex)|interpro:IPR006769(Protein of unknown function DUF607)|interpro:IPR039055|rcsb pdb:4XSJ|rcsb pdb:4XTB|rcsb pdb:5BZ6|rcsb pdb:5KUE|rcsb pdb:5KUG|rcsb pdb:5KUI|rcsb pdb:5KUJ|rcsb pdb:6JG0|rcsb pdb:6K7X|rcsb pdb:6K7Y|rcsb pdb:6KVX|rcsb pdb:6O58|rcsb pdb:6O5B|rcsb pdb:6WDN|rcsb pdb:6WDO|rcsb pdb:6XJV|rcsb pdb:6XJX|reactome:R-HSA-8949215|reactome:R-HSA-8949664|go:"GO:0019722"(calcium-mediated signaling)|ensembl:ENSG00000156026(gene)|ensembl:ENST00000373053(transcript)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0015292"(uniporter activity)|refseq:NP_001257608.1|refseq:NP_001257609.1|refseq:NP_612366.1|dip:DIP-60468N - - - figure legend:Figure 4B, 6B, 6D, 6G, Supp. fig. 6B|comment:The interaction occurs only in the absence but not in the presence of Ca2+|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens) - 2020/06/30 2020/07/01 rogid:ieoktRyh6dR8RvLctKOhbT84qPU9606 rogid:t2fSATmrk7IEC0nMpquAoPB3CHs9606 rigid:dyNj1q0cqLByZZM2UZDZVKOafbE false ha tag:c-c|mutation with no effect:463-463 flag tag:c-c - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9BPX6 uniprotkb:Q8NE86 intact:EBI-2371996|uniprotkb:O75785|uniprotkb:Q9H9N6|uniprotkb:Q9UFX0|uniprotkb:A8MV96|uniprotkb:B3KN20|uniprotkb:B4DJH9|uniprotkb:B4DPI1|uniprotkb:B5MBY3|uniprotkb:D3YTJ3|ensembl:ENSP00000354415 intact:EBI-6552124|ensembl:ENSP00000362144|uniprotkb:B2RDF3|uniprotkb:B3KXV7|uniprotkb:Q96FL3 psi-mi:micu1_human(display_long)|uniprotkb:MICU1(gene name)|psi-mi:MICU1(display_short)|uniprotkb:Calcium-binding atopy-related autoantigen 1(gene name synonym)|uniprotkb:CBARA1(gene name synonym)|uniprotkb:CALC(gene name synonym)|uniprotkb:Atopy-related autoantigen CALC(gene name synonym) psi-mi:mcu_human(display_long)|uniprotkb:MCU(gene name)|psi-mi:MCU(display_short)|uniprotkb:C10orf42(gene name synonym)|uniprotkb:CCDC109A(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 109A(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Petrungaro et al. (2015) pubmed:26387864|imex:IM-28311 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-25745313|imex:IM-28311-17 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001182447.1|refseq:NP_001182448.1|refseq:NP_006068.2|dip:DIP-53438N|ensembl:ENSG00000107745(gene)|ensembl:ENST00000361114(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005622"(intracellular anatomical structure)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0006952"(defense response)|go:"GO:0032592"(integral component of mitochondrial membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0042802"(identical protein binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0070509"(calcium ion import)|go:"GO:1900069"(regulation of cellular hyperosmotic salinity response)|go:"GO:1990246"(uniplex complex)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR039800|rcsb pdb:4NSC|rcsb pdb:4NSD|rcsb pdb:6K7Y|rcsb pdb:6LB7|rcsb pdb:6LB8|rcsb pdb:6LE5|rcsb pdb:6WDN|rcsb pdb:6WDO|rcsb pdb:6XJX|rcsb pdb:6XQN|rcsb pdb:6XQO|reactome:R-HSA-8949215|reactome:R-HSA-8949664|rcsb pdb:6XJV go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0034704"(calcium channel complex)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1990246"(uniplex complex)|interpro:IPR006769(Protein of unknown function DUF607)|interpro:IPR039055|rcsb pdb:4XSJ|rcsb pdb:4XTB|rcsb pdb:5BZ6|rcsb pdb:5KUE|rcsb pdb:5KUG|rcsb pdb:5KUI|rcsb pdb:5KUJ|rcsb pdb:6JG0|rcsb pdb:6K7X|rcsb pdb:6K7Y|rcsb pdb:6KVX|rcsb pdb:6O58|rcsb pdb:6O5B|rcsb pdb:6WDN|rcsb pdb:6WDO|rcsb pdb:6XJV|rcsb pdb:6XJX|reactome:R-HSA-8949215|reactome:R-HSA-8949664|go:"GO:0019722"(calcium-mediated signaling)|ensembl:ENSG00000156026(gene)|ensembl:ENST00000373053(transcript)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0015292"(uniporter activity)|refseq:NP_001257608.1|refseq:NP_001257609.1|refseq:NP_612366.1|dip:DIP-60468N - - - figure legend:Figure 4A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens) - 2020/06/30 2020/07/01 rogid:ieoktRyh6dR8RvLctKOhbT84qPU9606 rogid:t2fSATmrk7IEC0nMpquAoPB3CHs9606 rigid:dyNj1q0cqLByZZM2UZDZVKOafbE false ha tag:c-c|mutation with no effect:463-463 flag tag:c-c - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9BPX6 uniprotkb:Q8N4Q1 intact:EBI-2371996|uniprotkb:O75785|uniprotkb:Q9H9N6|uniprotkb:Q9UFX0|uniprotkb:A8MV96|uniprotkb:B3KN20|uniprotkb:B4DJH9|uniprotkb:B4DPI1|uniprotkb:B5MBY3|uniprotkb:D3YTJ3|ensembl:ENSP00000354415 intact:EBI-2562213|uniprotkb:A8K3Z9|uniprotkb:Q96AI2|uniprotkb:Q96MY6|ensembl:ENSP00000380122 psi-mi:micu1_human(display_long)|uniprotkb:MICU1(gene name)|psi-mi:MICU1(display_short)|uniprotkb:Calcium-binding atopy-related autoantigen 1(gene name synonym)|uniprotkb:CBARA1(gene name synonym)|uniprotkb:CALC(gene name synonym)|uniprotkb:Atopy-related autoantigen CALC(gene name synonym) psi-mi:mia40_human(display_long)|uniprotkb:MIA40(gene name synonym)|uniprotkb:Coiled-coil-helix-coiled-coil-helix domain-containing protein 4(gene name synonym)|uniprotkb:CHCHD4(gene name)|psi-mi:CHCHD4(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Petrungaro et al. (2015) pubmed:26387864|imex:IM-28311 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-25745047|imex:IM-28311-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001182447.1|refseq:NP_001182448.1|refseq:NP_006068.2|dip:DIP-53438N|ensembl:ENSG00000107745(gene)|ensembl:ENST00000361114(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005622"(intracellular anatomical structure)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0006952"(defense response)|go:"GO:0032592"(integral component of mitochondrial membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0042802"(identical protein binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0070509"(calcium ion import)|go:"GO:1900069"(regulation of cellular hyperosmotic salinity response)|go:"GO:1990246"(uniplex complex)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR039800|rcsb pdb:4NSC|rcsb pdb:4NSD|rcsb pdb:6K7Y|rcsb pdb:6LB7|rcsb pdb:6LB8|rcsb pdb:6LE5|rcsb pdb:6WDN|rcsb pdb:6WDO|rcsb pdb:6XJX|rcsb pdb:6XQN|rcsb pdb:6XQO|reactome:R-HSA-8949215|reactome:R-HSA-8949664|rcsb pdb:6XJV refseq:NP_001091972.1|refseq:NP_653237.1|ensembl:ENSG00000163528(gene)|ensembl:ENST00000396914(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0018171"(peptidyl-cysteine oxidation)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0045041"(protein import into mitochondrial intermembrane space)|go:"GO:0051084"('de novo' posttranslational protein folding)|interpro:IPR010625(CHCH)|interpro:IPR039289|mint:Q8N4Q1|rcsb pdb:2K3J|rcsb pdb:2L0Y|reactome:R-HSA-1268020|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|dip:DIP-48483N - - - figure legend:Figure 2C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2020/06/30 2020/07/01 rogid:ieoktRyh6dR8RvLctKOhbT84qPU9606 rogid:ACH8CTQRjTwq7nz6toGTrn3VHlE9606 rigid:0f5fVmDhEigxKelXfeDnLI017Lg false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9BPX6 uniprotkb:Q8IYU8 intact:EBI-2371996|uniprotkb:O75785|uniprotkb:Q9H9N6|uniprotkb:Q9UFX0|uniprotkb:A8MV96|uniprotkb:B3KN20|uniprotkb:B4DJH9|uniprotkb:B4DPI1|uniprotkb:B5MBY3|uniprotkb:D3YTJ3|ensembl:ENSP00000354415 intact:EBI-3197790|ensembl:ENSP00000371811|uniprotkb:Q8N0T6|uniprotkb:Q8NAX8 psi-mi:micu1_human(display_long)|uniprotkb:MICU1(gene name)|psi-mi:MICU1(display_short)|uniprotkb:Calcium-binding atopy-related autoantigen 1(gene name synonym)|uniprotkb:CBARA1(gene name synonym)|uniprotkb:CALC(gene name synonym)|uniprotkb:Atopy-related autoantigen CALC(gene name synonym) psi-mi:micu2_human(display_long)|uniprotkb:MICU2(gene name)|psi-mi:MICU2(display_short)|uniprotkb:EF-hand domain-containing family member A1(gene name synonym)|uniprotkb:EFHA1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Petrungaro et al. (2015) pubmed:26387864|imex:IM-28311 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-25745066|imex:IM-28311-21 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001182447.1|refseq:NP_001182448.1|refseq:NP_006068.2|dip:DIP-53438N|ensembl:ENSG00000107745(gene)|ensembl:ENST00000361114(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005622"(intracellular anatomical structure)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0006952"(defense response)|go:"GO:0032592"(integral component of mitochondrial membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0042802"(identical protein binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0070509"(calcium ion import)|go:"GO:1900069"(regulation of cellular hyperosmotic salinity response)|go:"GO:1990246"(uniplex complex)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR039800|rcsb pdb:4NSC|rcsb pdb:4NSD|rcsb pdb:6K7Y|rcsb pdb:6LB7|rcsb pdb:6LB8|rcsb pdb:6LE5|rcsb pdb:6WDN|rcsb pdb:6WDO|rcsb pdb:6XJX|rcsb pdb:6XQN|rcsb pdb:6XQO|reactome:R-HSA-8949215|reactome:R-HSA-8949664|rcsb pdb:6XJV ensembl:ENSG00000165487(gene)|ensembl:ENST00000382374(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0034704"(calcium channel complex)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0051562"(negative regulation of mitochondrial calcium ion concentration)|go:"GO:1990246"(uniplex complex)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR039800|rcsb pdb:6AGH|rcsb pdb:6IIH|rcsb pdb:6K7Y|rcsb pdb:6LB7|rcsb pdb:6LB8|rcsb pdb:6LE5|rcsb pdb:6WDN|rcsb pdb:6WDO|rcsb pdb:6XJV|rcsb pdb:6XJX|rcsb pdb:6XQN|rcsb pdb:6XQO|reactome:R-HSA-8949215|reactome:R-HSA-8949664|refseq:NP_689939.1 - - - comment:CHCHD2/9 also identified but could not be resolved to a single gene product|figure legend:Figure 3A, 3C, 3D|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2020/06/30 2020/07/01 rogid:ieoktRyh6dR8RvLctKOhbT84qPU9606 rogid:qj7nAE+DvoW/RWlr4VWGSbhS6Mc9606 rigid:QgBUPv87WvTQeepSTaccY6umNAc false 35s radiolabel:?-? 35s radiolabel:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:Q9BPX6 uniprotkb:Q8IYU8 intact:EBI-2371996|uniprotkb:O75785|uniprotkb:Q9H9N6|uniprotkb:Q9UFX0|uniprotkb:A8MV96|uniprotkb:B3KN20|uniprotkb:B4DJH9|uniprotkb:B4DPI1|uniprotkb:B5MBY3|uniprotkb:D3YTJ3|ensembl:ENSP00000354415 intact:EBI-3197790|ensembl:ENSP00000371811|uniprotkb:Q8N0T6|uniprotkb:Q8NAX8 psi-mi:micu1_human(display_long)|uniprotkb:MICU1(gene name)|psi-mi:MICU1(display_short)|uniprotkb:Calcium-binding atopy-related autoantigen 1(gene name synonym)|uniprotkb:CBARA1(gene name synonym)|uniprotkb:CALC(gene name synonym)|uniprotkb:Atopy-related autoantigen CALC(gene name synonym) psi-mi:micu2_human(display_long)|uniprotkb:MICU2(gene name)|psi-mi:MICU2(display_short)|uniprotkb:EF-hand domain-containing family member A1(gene name synonym)|uniprotkb:EFHA1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Petrungaro et al. (2015) pubmed:26387864|imex:IM-28311 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-25745256|imex:IM-28311-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001182447.1|refseq:NP_001182448.1|refseq:NP_006068.2|dip:DIP-53438N|ensembl:ENSG00000107745(gene)|ensembl:ENST00000361114(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005622"(intracellular anatomical structure)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0006952"(defense response)|go:"GO:0032592"(integral component of mitochondrial membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0042802"(identical protein binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0070509"(calcium ion import)|go:"GO:1900069"(regulation of cellular hyperosmotic salinity response)|go:"GO:1990246"(uniplex complex)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR039800|rcsb pdb:4NSC|rcsb pdb:4NSD|rcsb pdb:6K7Y|rcsb pdb:6LB7|rcsb pdb:6LB8|rcsb pdb:6LE5|rcsb pdb:6WDN|rcsb pdb:6WDO|rcsb pdb:6XJX|rcsb pdb:6XQN|rcsb pdb:6XQO|reactome:R-HSA-8949215|reactome:R-HSA-8949664|rcsb pdb:6XJV ensembl:ENSG00000165487(gene)|ensembl:ENST00000382374(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0034704"(calcium channel complex)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0051562"(negative regulation of mitochondrial calcium ion concentration)|go:"GO:1990246"(uniplex complex)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR039800|rcsb pdb:6AGH|rcsb pdb:6IIH|rcsb pdb:6K7Y|rcsb pdb:6LB7|rcsb pdb:6LB8|rcsb pdb:6LE5|rcsb pdb:6WDN|rcsb pdb:6WDO|rcsb pdb:6XJV|rcsb pdb:6XJX|rcsb pdb:6XQN|rcsb pdb:6XQO|reactome:R-HSA-8949215|reactome:R-HSA-8949664|refseq:NP_689939.1 - - - figure legend:Figure 3A, 3C, 3D|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2020/06/30 2020/07/01 rogid:ieoktRyh6dR8RvLctKOhbT84qPU9606 rogid:qj7nAE+DvoW/RWlr4VWGSbhS6Mc9606 rigid:QgBUPv87WvTQeepSTaccY6umNAc false 35s radiolabel:?-? 35s radiolabel:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:Q9BPX6 uniprotkb:Q8NE86 intact:EBI-2371996|uniprotkb:O75785|uniprotkb:Q9H9N6|uniprotkb:Q9UFX0|uniprotkb:A8MV96|uniprotkb:B3KN20|uniprotkb:B4DJH9|uniprotkb:B4DPI1|uniprotkb:B5MBY3|uniprotkb:D3YTJ3|ensembl:ENSP00000354415 intact:EBI-6552124|ensembl:ENSP00000362144|uniprotkb:B2RDF3|uniprotkb:B3KXV7|uniprotkb:Q96FL3 psi-mi:micu1_human(display_long)|uniprotkb:MICU1(gene name)|psi-mi:MICU1(display_short)|uniprotkb:Calcium-binding atopy-related autoantigen 1(gene name synonym)|uniprotkb:CBARA1(gene name synonym)|uniprotkb:CALC(gene name synonym)|uniprotkb:Atopy-related autoantigen CALC(gene name synonym) psi-mi:mcu_human(display_long)|uniprotkb:MCU(gene name)|psi-mi:MCU(display_short)|uniprotkb:C10orf42(gene name synonym)|uniprotkb:CCDC109A(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 109A(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Petrungaro et al. (2015) pubmed:26387864|imex:IM-28311 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0486"(UniProt) intact:EBI-25745500|imex:IM-28311-19 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001182447.1|refseq:NP_001182448.1|refseq:NP_006068.2|dip:DIP-53438N|ensembl:ENSG00000107745(gene)|ensembl:ENST00000361114(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005622"(intracellular anatomical structure)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0006952"(defense response)|go:"GO:0032592"(integral component of mitochondrial membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0042802"(identical protein binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0070509"(calcium ion import)|go:"GO:1900069"(regulation of cellular hyperosmotic salinity response)|go:"GO:1990246"(uniplex complex)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR039800|rcsb pdb:4NSC|rcsb pdb:4NSD|rcsb pdb:6K7Y|rcsb pdb:6LB7|rcsb pdb:6LB8|rcsb pdb:6LE5|rcsb pdb:6WDN|rcsb pdb:6WDO|rcsb pdb:6XJX|rcsb pdb:6XQN|rcsb pdb:6XQO|reactome:R-HSA-8949215|reactome:R-HSA-8949664|rcsb pdb:6XJV go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0034704"(calcium channel complex)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1990246"(uniplex complex)|interpro:IPR006769(Protein of unknown function DUF607)|interpro:IPR039055|rcsb pdb:4XSJ|rcsb pdb:4XTB|rcsb pdb:5BZ6|rcsb pdb:5KUE|rcsb pdb:5KUG|rcsb pdb:5KUI|rcsb pdb:5KUJ|rcsb pdb:6JG0|rcsb pdb:6K7X|rcsb pdb:6K7Y|rcsb pdb:6KVX|rcsb pdb:6O58|rcsb pdb:6O5B|rcsb pdb:6WDN|rcsb pdb:6WDO|rcsb pdb:6XJV|rcsb pdb:6XJX|reactome:R-HSA-8949215|reactome:R-HSA-8949664|go:"GO:0019722"(calcium-mediated signaling)|ensembl:ENSG00000156026(gene)|ensembl:ENST00000373053(transcript)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0015292"(uniporter activity)|refseq:NP_001257608.1|refseq:NP_001257609.1|refseq:NP_612366.1|dip:DIP-60468N go:"GO:0005739"(mitochondrion) - - figure legend:Supp. Figure 1C|comment:The interaction occurs only in the absence but not in the presence of Ca2+|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens) - 2020/06/30 2020/07/01 rogid:ieoktRyh6dR8RvLctKOhbT84qPU9606 rogid:t2fSATmrk7IEC0nMpquAoPB3CHs9606 rigid:dyNj1q0cqLByZZM2UZDZVKOafbE false ha tag:c-c|mutation with no effect:463-463 flag tag:c-c - - psi-mi:"MI:1201"(anti-tag immunocytochemistry) psi-mi:"MI:1201"(anti-tag immunocytochemistry)