#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P52823 uniprotkb:P52823 intact:EBI-12268818|ensembl:ENSP00000290271|uniprotkb:B4DN22|uniprotkb:Q71UE5 intact:EBI-12268818|ensembl:ENSP00000290271|uniprotkb:B4DN22|uniprotkb:Q71UE5 psi-mi:stc1_human(display_long)|uniprotkb:STC1(gene name)|psi-mi:STC1(display_short)|uniprotkb:STC(gene name synonym) psi-mi:stc1_human(display_long)|uniprotkb:STC1(gene name)|psi-mi:STC1(display_short)|uniprotkb:STC(gene name synonym) psi-mi:"MI:0404"(comigration in non denaturing gel electrophoresis) Kløverpris et al. (2015) imex:IM-27992|pubmed:26195635 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0486"(UniProt) intact:EBI-25612888|imex:IM-27992-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0035988"(chondrocyte proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0044070"(regulation of anion transport)|go:"GO:0046697"(decidualization)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0060348"(bone development)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1903403"(negative regulation of renal phosphate excretion)|interpro:IPR004978(Stanniocalcin)|go:"GO:0033280"(response to vitamin D)|ensembl:ENSG00000159167(gene)|ensembl:ENST00000290271(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001886"(endothelial cell morphogenesis)|go:"GO:0003421"(growth plate cartilage axis specification)|go:"GO:0005179"(hormone activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007566"(embryo implantation)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030336"(negative regulation of cell migration)|refseq:NP_003146.1 go:"GO:0035988"(chondrocyte proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0044070"(regulation of anion transport)|go:"GO:0046697"(decidualization)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0060348"(bone development)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1903403"(negative regulation of renal phosphate excretion)|interpro:IPR004978(Stanniocalcin)|go:"GO:0033280"(response to vitamin D)|ensembl:ENSG00000159167(gene)|ensembl:ENST00000290271(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001886"(endothelial cell morphogenesis)|go:"GO:0003421"(growth plate cartilage axis specification)|go:"GO:0005179"(hormone activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007566"(embryo implantation)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030336"(negative regulation of cell migration)|refseq:NP_003146.1 - - - figure legend:Fig. 2A,|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2020/05/18 2020/05/18 rogid:0Ve9JjjgCCQEsygZa1AkagTBESs9606 rogid:0Ve9JjjgCCQEsygZa1AkagTBESs9606 rigid:Zp5+et+AMSFeoM83cqPd/A531PM false his tag:?-? his tag:?-? 1 1 psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)|psi-mi:"MI:0039"(edman degradation) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)|psi-mi:"MI:0039"(edman degradation) uniprotkb:P52823 uniprotkb:P52823 intact:EBI-12268818|ensembl:ENSP00000290271|uniprotkb:B4DN22|uniprotkb:Q71UE5 intact:EBI-12268818|ensembl:ENSP00000290271|uniprotkb:B4DN22|uniprotkb:Q71UE5 psi-mi:stc1_human(display_long)|uniprotkb:STC1(gene name)|psi-mi:STC1(display_short)|uniprotkb:STC(gene name synonym) psi-mi:stc1_human(display_long)|uniprotkb:STC1(gene name)|psi-mi:STC1(display_short)|uniprotkb:STC(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Kløverpris et al. (2015) imex:IM-27992|pubmed:26195635 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0486"(UniProt) intact:EBI-25612905|imex:IM-27992-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0035988"(chondrocyte proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0044070"(regulation of anion transport)|go:"GO:0046697"(decidualization)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0060348"(bone development)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1903403"(negative regulation of renal phosphate excretion)|interpro:IPR004978(Stanniocalcin)|go:"GO:0033280"(response to vitamin D)|ensembl:ENSG00000159167(gene)|ensembl:ENST00000290271(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001886"(endothelial cell morphogenesis)|go:"GO:0003421"(growth plate cartilage axis specification)|go:"GO:0005179"(hormone activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007566"(embryo implantation)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030336"(negative regulation of cell migration)|refseq:NP_003146.1 go:"GO:0035988"(chondrocyte proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0044070"(regulation of anion transport)|go:"GO:0046697"(decidualization)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0060348"(bone development)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1903403"(negative regulation of renal phosphate excretion)|interpro:IPR004978(Stanniocalcin)|go:"GO:0033280"(response to vitamin D)|ensembl:ENSG00000159167(gene)|ensembl:ENST00000290271(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001886"(endothelial cell morphogenesis)|go:"GO:0003421"(growth plate cartilage axis specification)|go:"GO:0005179"(hormone activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007566"(embryo implantation)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030336"(negative regulation of cell migration)|refseq:NP_003146.1 - - - figure legend:Fig. 2B, 3, Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2020/05/18 2020/05/18 rogid:0Ve9JjjgCCQEsygZa1AkagTBESs9606 rogid:0Ve9JjjgCCQEsygZa1AkagTBESs9606 rigid:Zp5+et+AMSFeoM83cqPd/A531PM false his tag:?-?|cross linker:202-202 his tag:?-?|cross linker:202-202 1 1 psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)|psi-mi:"MI:0082"(peptide massfingerprinting) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)|psi-mi:"MI:0082"(peptide massfingerprinting) uniprotkb:Q13219 uniprotkb:P52823 intact:EBI-1221991|uniprotkb:Q08371|uniprotkb:Q68G52|uniprotkb:Q9UDK7|uniprotkb:B1AMF9|ensembl:ENSP00000330658 intact:EBI-12268818|ensembl:ENSP00000290271|uniprotkb:B4DN22|uniprotkb:Q71UE5 psi-mi:papp1_human(display_long)|uniprotkb:PAPPA(gene name)|psi-mi:PAPPA(display_short)|uniprotkb:Pregnancy-associated plasma protein A(gene name synonym)|uniprotkb:Insulin-like growth factor-dependent IGF-binding protein 4 protease(gene name synonym) psi-mi:stc1_human(display_long)|uniprotkb:STC1(gene name)|psi-mi:STC1(display_short)|uniprotkb:STC(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) Kløverpris et al. (2015) imex:IM-27992|pubmed:26195635 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0486"(UniProt) intact:EBI-25612949|imex:IM-27992-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002572.2|ensembl:ENSG00000182752(gene)|ensembl:ENST00000328252(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007565"(female pregnancy)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0032354"(response to follicle-stimulating hormone)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0051384"(response to glucocorticoid)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR000800(Notch region)|interpro:IPR006558(LamG-like jellyroll fold)|interpro:IPR008754(Peptidase M43B, pregnancy-associated plasma-A)|interpro:IPR011936(Myxococcus cysteine-rich repeat)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR024079|interpro:IPR030433|interpro:IPR035976|interpro:IPR043543|reactome:R-HSA-381426 go:"GO:0035988"(chondrocyte proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0044070"(regulation of anion transport)|go:"GO:0046697"(decidualization)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0060348"(bone development)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1903403"(negative regulation of renal phosphate excretion)|interpro:IPR004978(Stanniocalcin)|go:"GO:0033280"(response to vitamin D)|ensembl:ENSG00000159167(gene)|ensembl:ENST00000290271(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001886"(endothelial cell morphogenesis)|go:"GO:0003421"(growth plate cartilage axis specification)|go:"GO:0005179"(hormone activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007566"(embryo implantation)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030336"(negative regulation of cell migration)|refseq:NP_003146.1 - - - figure legend:Fig. 5A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:7.5x10^-11(molar) 2020/05/18 2020/05/19 rogid:N9by5mwLLG+HMB9KCZhmOP4tW5g9606 rogid:0Ve9JjjgCCQEsygZa1AkagTBESs9606 rigid:4XOzuHeyY6M9KkTnDEEfL/vlx3Y false - his tag:?-? - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)