#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
chebi:"CHEBI:149679"	uniprotkb:K9N7C7-PRO_0000422443	intact:EBI-25596057	intact:EBI-25592576	psi-mi:compound number 6(display_short)|psi-mi:"CHEBI:149679"(display_long)	psi-mi:k9n7c7-pro_0000422443(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0114"(x-ray crystallography)	Tomar et al. (2015)	imex:IM-27970|pubmed:26055715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:1263720(cvemc)|taxid:1263720("Middle East respiratory syndrome-related coronavirus (isolate United Kingdom/H123990006/2012) (Betacoronavirus England 1)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25595989|wwpdb:4RSP|imex:IM-27970-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	intact:EBI-25591996(chain-parent)	-	-	chain-seq-start:3248|chain-seq-end:3553	figure legend:Table 4|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/05/07	2020/05/07	-	rogid:y7LRjUSjTxAlsiZYr/YWDysjvA81263720	-	false	-	L-cysteine sulfenic acid:145-145	-	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:149680"	uniprotkb:K9N7C7-PRO_0000422443	intact:EBI-25596070	intact:EBI-25592576	psi-mi:compound number 11(display_short)|psi-mi:"CHEBI:149680"(display_long)	psi-mi:k9n7c7-pro_0000422443(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0114"(x-ray crystallography)	Tomar et al. (2015)	imex:IM-27970|pubmed:26055715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:1263720(cvemc)|taxid:1263720("Middle East respiratory syndrome-related coronavirus (isolate United Kingdom/H123990006/2012) (Betacoronavirus England 1)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25595991|wwpdb:4YLU|imex:IM-27970-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	intact:EBI-25591996(chain-parent)	-	-	chain-seq-start:3248|chain-seq-end:3553	figure legend:table 4|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/05/07	2020/05/07	-	rogid:y7LRjUSjTxAlsiZYr/YWDysjvA81263720	-	false	-	-	-	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-25596087	uniprotkb:K9N7C7-PRO_0000422443	-	intact:EBI-25592576	psi-mi:generic peptide substrate(display_short)|psi-mi:EBI-25596087(display_long)	psi-mi:k9n7c7-pro_0000422443(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0435"(protease assay)	Tomar et al. (2015)	imex:IM-27970|pubmed:26055715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:1263720(cvemc)|taxid:1263720("Middle East respiratory syndrome-related coronavirus (isolate United Kingdom/H123990006/2012) (Betacoronavirus England 1)")	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25596084|imex:IM-27970-21	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0327"(peptide)	psi-mi:"MI:0326"(protein)	-	intact:EBI-25591996(chain-parent)	-	-	chain-seq-start:3248|chain-seq-end:3553	figure legend:1A/B, 2,  number 1, figure 3, 5A|kinetics:"The enzymatic efficiency of MERS-CoV 3CLpro (kcat/Km = 3.1 ± 0.03 × 10E2 /um /min) is noticeably lower than other 3CLpro enzymes tested."|comment:The response of MERS-CoV 3CLpro enzymatic activity to an increasing enzyme concentration is nonlinear. There is a substantial reduction in the ability of MERS-CoV 3CLpro to dimerize compared with the other 3CLpro enzymes.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/05/07	2020/05/07	rogid:2I7yQsEkeM0SyIiEBpBFPXy67KA-2	rogid:y7LRjUSjTxAlsiZYr/YWDysjvA81263720	rigid:Qyv2qvAabU5XRy4IDlM8GhvAKjM	false	qx 520:c-c|hilyte fluor 488:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-25596087	uniprotkb:P0C6X7-PRO_0000037312	-	intact:EBI-25487250	psi-mi:generic peptide substrate(display_short)|psi-mi:EBI-25596087(display_long)	psi-mi:p0c6x7-pro_0000037312(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0435"(protease assay)	Tomar et al. (2015)	imex:IM-27970|pubmed:26055715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25596831|imex:IM-27970-5	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0327"(peptide)	psi-mi:"MI:0326"(protein)	-	intact:EBI-7843867(chain-parent)	-	-	chain-seq-start:3241|chain-seq-end:3546	figure legend:1A/B, 2,  number 2|kinetics:"kcat/Km =15.5  × 10E2 /um /min)"|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/05/07	2020/05/11	rogid:2I7yQsEkeM0SyIiEBpBFPXy67KA-2	rogid:6LbRC/jITHtqNPZLpKst/+pNdOQ694009	rigid:2/nI5sRPUJSfdGbQT9W6dX2l09o	false	qx 520:c-c|hilyte fluor 488:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-25596087	uniprotkb:P0C6W4-PRO_0000290307	-	intact:EBI-25596950	psi-mi:generic peptide substrate(display_short)|psi-mi:EBI-25596087(display_long)	psi-mi:p0c6w4-pro_0000290307(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0435"(protease assay)	Tomar et al. (2015)	imex:IM-27970|pubmed:26055715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:694008(BtCoV-1)|taxid:694008(Bat coronavirus HKU5)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25596845|imex:IM-27970-7	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0327"(peptide)	psi-mi:"MI:0326"(protein)	-	intact:EBI-25596878(chain-parent)	-	-	chain-seq-start:3339|chain-seq-end:3644	figure legend:1A/B, 2,  number 3|kinetics:"kcat/Km =8.8  × 10E2 /um /min)"|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/05/07	2020/05/11	rogid:2I7yQsEkeM0SyIiEBpBFPXy67KA-2	rogid:4zplVKoZ7AI5c/ak1aqJMCzNVU4694008	rigid:PEj8PPQwQOebDGXwzNrrbSwNtI4	false	qx 520:c-c|hilyte fluor 488:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-25596087	uniprotkb:P0C6W3-PRO_0000290292	-	intact:EBI-25597045	psi-mi:generic peptide substrate(display_short)|psi-mi:EBI-25596087(display_long)	psi-mi:p0c6w3-pro_0000290292(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0435"(protease assay)	Tomar et al. (2015)	imex:IM-27970|pubmed:26055715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:694007(BtCoV)|taxid:694007(Bat coronavirus HKU4)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25596956|imex:IM-27970-9	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0327"(peptide)	psi-mi:"MI:0326"(protein)	-	intact:EBI-25596965(chain-parent)	-	-	chain-seq-start:3292|chain-seq-end:3597	figure legend:1A/B, 2,  number 4|kinetics:"kcat/Km =11.3  × 10E2 /um /min)"|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/05/07	2020/05/11	rogid:2I7yQsEkeM0SyIiEBpBFPXy67KA-2	rogid:ftPCTmpPVr9XG8ladR96sNOZ6/A694007	rigid:hLcUo64bt0YsuDOGPw92CZlaEj0	false	qx 520:c-c|hilyte fluor 488:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:149679"	intact:EBI-25596087	intact:EBI-25596057	-	psi-mi:compound number 6(display_short)|psi-mi:"CHEBI:149679"(display_long)	psi-mi:generic peptide substrate(display_short)|psi-mi:EBI-25596087(display_long)	psi-mi:"MI:0435"(protease assay)	Tomar et al. (2015)	imex:IM-27970|pubmed:26055715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25597053|imex:IM-27970-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0327"(peptide)	-	-	-	-	-	figure legend:Figure 3, Table 3|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ki:3.6x10^-6(molar)	2020/05/07	2020/05/11	-	rogid:2I7yQsEkeM0SyIiEBpBFPXy67KA-2	-	false	-	qx 520:c-c|hilyte fluor 488:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:149679"	uniprotkb:K9N7C7-PRO_0000422443	intact:EBI-25596057	intact:EBI-25592576	psi-mi:compound number 6(display_short)|psi-mi:"CHEBI:149679"(display_long)	psi-mi:k9n7c7-pro_0000422443(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0435"(protease assay)	Tomar et al. (2015)	imex:IM-27970|pubmed:26055715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:1263720(cvemc)|taxid:1263720("Middle East respiratory syndrome-related coronavirus (isolate United Kingdom/H123990006/2012) (Betacoronavirus England 1)")	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25597053|imex:IM-27970-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	intact:EBI-25591996(chain-parent)	-	-	chain-seq-start:3248|chain-seq-end:3553	figure legend:Figure 3, Table 3|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ki:3.6x10^-6(molar)	2020/05/07	2020/05/11	-	rogid:y7LRjUSjTxAlsiZYr/YWDysjvA81263720	-	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:149679"	intact:EBI-25596087	intact:EBI-25596057	-	psi-mi:compound number 6(display_short)|psi-mi:"CHEBI:149679"(display_long)	psi-mi:generic peptide substrate(display_short)|psi-mi:EBI-25596087(display_long)	psi-mi:"MI:0435"(protease assay)	Tomar et al. (2015)	imex:IM-27970|pubmed:26055715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25597065|imex:IM-27970-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0327"(peptide)	-	-	-	-	-	figure legend:text only, HKU5|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ki:0.49x10^-6(molar)	2020/05/07	2020/05/11	-	rogid:2I7yQsEkeM0SyIiEBpBFPXy67KA-2	-	false	-	qx 520:c-c|hilyte fluor 488:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:149679"	uniprotkb:P0C6W4-PRO_0000290307	intact:EBI-25596057	intact:EBI-25596950	psi-mi:compound number 6(display_short)|psi-mi:"CHEBI:149679"(display_long)	psi-mi:p0c6w4-pro_0000290307(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0435"(protease assay)	Tomar et al. (2015)	imex:IM-27970|pubmed:26055715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:694008(BtCoV-1)|taxid:694008(Bat coronavirus HKU5)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25597065|imex:IM-27970-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	intact:EBI-25596878(chain-parent)	-	-	chain-seq-start:3339|chain-seq-end:3644	figure legend:text only, HKU5|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ki:0.49x10^-6(molar)	2020/05/07	2020/05/11	-	rogid:4zplVKoZ7AI5c/ak1aqJMCzNVU4694008	-	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:149679"	intact:EBI-25596087	intact:EBI-25596057	-	psi-mi:compound number 6(display_short)|psi-mi:"CHEBI:149679"(display_long)	psi-mi:generic peptide substrate(display_short)|psi-mi:EBI-25596087(display_long)	psi-mi:"MI:0435"(protease assay)	Tomar et al. (2015)	imex:IM-27970|pubmed:26055715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25597075|imex:IM-27970-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0327"(peptide)	-	-	-	-	-	figure legend:text only, HKU4|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ki:0.39x10^-6(molar)	2020/05/07	2020/05/11	-	rogid:2I7yQsEkeM0SyIiEBpBFPXy67KA-2	-	false	-	qx 520:c-c|hilyte fluor 488:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:149679"	uniprotkb:P0C6W3-PRO_0000290292	intact:EBI-25596057	intact:EBI-25597045	psi-mi:compound number 6(display_short)|psi-mi:"CHEBI:149679"(display_long)	psi-mi:p0c6w3-pro_0000290292(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0435"(protease assay)	Tomar et al. (2015)	imex:IM-27970|pubmed:26055715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:694007(BtCoV)|taxid:694007(Bat coronavirus HKU4)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25597075|imex:IM-27970-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	intact:EBI-25596965(chain-parent)	-	-	chain-seq-start:3292|chain-seq-end:3597	figure legend:text only, HKU4|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ki:0.39x10^-6(molar)	2020/05/07	2020/05/11	-	rogid:ftPCTmpPVr9XG8ladR96sNOZ6/A694007	-	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:149693"	intact:EBI-25596087	intact:EBI-25597149	-	psi-mi:compound 10(display_short)|psi-mi:"CHEBI:149693"(display_long)	psi-mi:generic peptide substrate(display_short)|psi-mi:EBI-25596087(display_long)	psi-mi:"MI:0435"(protease assay)	Tomar et al. (2015)	imex:IM-27970|pubmed:26055715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25597139|imex:IM-27970-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0327"(peptide)	-	-	-	-	-	figure legend:Table 3, figure 5A|inhibition:"Ki=>100uM. Data from Table 3 derived from these experimentaal conditions: incubation of 500 nm MERS-CoV 3CLpro with 50 um of  compound 10."|comment:"An increase in the activity of MERS-CoV 3CLpro, as high as 195%, was observed in the presence of low inhibitor concentrations (0.1 to 20 um). Inhibition of enzymatic activity was observed only at higher inhibitor concentrations (40 um or greater)."|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/05/07	2020/05/11	-	rogid:2I7yQsEkeM0SyIiEBpBFPXy67KA-2	-	false	-	qx 520:c-c|hilyte fluor 488:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:149693"	uniprotkb:K9N7C7-PRO_0000422443	intact:EBI-25597149	intact:EBI-25592576	psi-mi:compound 10(display_short)|psi-mi:"CHEBI:149693"(display_long)	psi-mi:k9n7c7-pro_0000422443(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0435"(protease assay)	Tomar et al. (2015)	imex:IM-27970|pubmed:26055715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:1263720(cvemc)|taxid:1263720("Middle East respiratory syndrome-related coronavirus (isolate United Kingdom/H123990006/2012) (Betacoronavirus England 1)")	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25597139|imex:IM-27970-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	intact:EBI-25591996(chain-parent)	-	-	chain-seq-start:3248|chain-seq-end:3553	figure legend:Table 3, figure 5A|inhibition:"Ki=>100uM. Data from Table 3 derived from these experimentaal conditions: incubation of 500 nm MERS-CoV 3CLpro with 50 um of  compound 10."|comment:"An increase in the activity of MERS-CoV 3CLpro, as high as 195%, was observed in the presence of low inhibitor concentrations (0.1 to 20 um). Inhibition of enzymatic activity was observed only at higher inhibitor concentrations (40 um or greater)."|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/05/07	2020/05/11	-	rogid:y7LRjUSjTxAlsiZYr/YWDysjvA81263720	-	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:K9N7C7-PRO_0000422443	uniprotkb:K9N7C7-PRO_0000422443	intact:EBI-25592576	intact:EBI-25592576	psi-mi:k9n7c7-pro_0000422443(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:k9n7c7-pro_0000422443(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0028"(cosedimentation in solution)	Tomar et al. (2015)	imex:IM-27970|pubmed:26055715	taxid:1263720(cvemc)|taxid:1263720("Middle East respiratory syndrome-related coronavirus (isolate United Kingdom/H123990006/2012) (Betacoronavirus England 1)")	taxid:1263720(cvemc)|taxid:1263720("Middle East respiratory syndrome-related coronavirus (isolate United Kingdom/H123990006/2012) (Betacoronavirus England 1)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25597094|imex:IM-27970-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-25591996(chain-parent)	intact:EBI-25591996(chain-parent)	-	chain-seq-start:3248|chain-seq-end:3553	chain-seq-start:3248|chain-seq-end:3553	figure legend:4A|comment:The dimer peak becoming more pronounced at higher enzyme concentrations.|agonist:"Compound 6 -CHEBI:149679"|agonist:"Compound 10 -CHEBI:149693"|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:52.0x10^-6(molar)	2020/05/07	2020/05/11	rogid:y7LRjUSjTxAlsiZYr/YWDysjvA81263720	rogid:y7LRjUSjTxAlsiZYr/YWDysjvA81263720	rigid:RS3Aga9NH9xFly5UR0ILgy4YTaA	false	-	-	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:149679"	uniprotkb:K9N7C7-PRO_0000422443	intact:EBI-25596057	intact:EBI-25592576	psi-mi:compound number 6(display_short)|psi-mi:"CHEBI:149679"(display_long)	psi-mi:k9n7c7-pro_0000422443(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0028"(cosedimentation in solution)	Tomar et al. (2015)	imex:IM-27970|pubmed:26055715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:1263720(cvemc)|taxid:1263720("Middle East respiratory syndrome-related coronavirus (isolate United Kingdom/H123990006/2012) (Betacoronavirus England 1)")	psi-mi:"MI:0195"(covalent binding)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25597124|imex:IM-27970-15	-	-	psi-mi:"MI:0840"(stimulator)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	intact:EBI-25591996(chain-parent)	-	-	chain-seq-start:3248|chain-seq-end:3553	figure legend:4B|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/05/07	2020/05/11	-	rogid:y7LRjUSjTxAlsiZYr/YWDysjvA81263720	-	false	binding-associated region:?-?	L-cysteine residue:?-?	-	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:149693"	uniprotkb:K9N7C7-PRO_0000422443	intact:EBI-25597149	intact:EBI-25592576	psi-mi:compound 10(display_short)|psi-mi:"CHEBI:149693"(display_long)	psi-mi:k9n7c7-pro_0000422443(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0028"(cosedimentation in solution)	Tomar et al. (2015)	imex:IM-27970|pubmed:26055715	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:1263720(cvemc)|taxid:1263720("Middle East respiratory syndrome-related coronavirus (isolate United Kingdom/H123990006/2012) (Betacoronavirus England 1)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25597168|imex:IM-27970-19	-	-	psi-mi:"MI:0840"(stimulator)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	intact:EBI-25591996(chain-parent)	-	-	chain-seq-start:3248|chain-seq-end:3553	figure legend:4C|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/05/07	2020/05/11	-	rogid:y7LRjUSjTxAlsiZYr/YWDysjvA81263720	-	false	-	-	-	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)