#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P32366	uniprotkb:P17255	intact:EBI-20201|uniprotkb:D6VZ81|ensemblfungi:YLR447C	intact:EBI-20245|uniprotkb:O74301|uniprotkb:Q9Y7W5|uniprotkb:D6VRG7|ensemblfungi:YDL185W	psi-mi:va0d_yeast(display_long)|uniprotkb:VMA6(gene name)|psi-mi:VMA6(display_short)|uniprotkb:YLR447C(locus name)|uniprotkb:L9324.8(orf name)|uniprotkb:Vacuolar proton pump subunit d(gene name synonym)|uniprotkb:V-ATPase 39 kDa subunit(gene name synonym)|uniprotkb:V-ATPase subunit M39(gene name synonym)	psi-mi:vata_yeast(display_long)|uniprotkb:VMA1(gene name)|psi-mi:VMA1(display_short)|uniprotkb:CLS8(gene name synonym)|uniprotkb:TFP1(gene name synonym)|uniprotkb:YDL185W(locus name)|uniprotkb:D1286(orf name)|uniprotkb:Vacuolar proton pump subunit A(gene name synonym)	psi-mi:"MI:2338"(electron tomography)	Zhao et al. (2015)	imex:IM-27701|pubmed:25971514	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-25419483|wwpdb:3J9T|wwpdb:3J9U|wwpdb:3J9V|emdb:EMD-6284|emdb:EMD-6285|emdb:EMD-6286|imex:IM-27701-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000004439|refseq:NP_013552.3|mint:P32366|interpro:IPR016727(ATPase, V0 complex, subunit D)|interpro:IPR035067|interpro:IPR036079|interpro:IPR044911|rcsb pdb:3J9T|rcsb pdb:3J9U|rcsb pdb:3J9V|rcsb pdb:5TJ5|rcsb pdb:5VOX|rcsb pdb:5VOY|rcsb pdb:5VOZ|rcsb pdb:6C6L|rcsb pdb:6M0R|rcsb pdb:6M0S|rcsb pdb:6O7T|rcsb pdb:6O7U|interpro:IPR002843(ATPase, V0/A0 complex, subunit C/D)|rcsb pdb:6O7V|rcsb pdb:6O7W|rcsb pdb:6O7X|ensemblfungi:YLR447C(gene)|ensemblfungi:YLR447C_mRNA(transcript)|go:"GO:0000220"(vacuolar proton-transporting V-type ATPase, V0 domain)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0007034"(vacuolar transport)|go:"GO:0007035"(vacuolar acidification)|go:"GO:0016471"(vacuolar proton-transporting V-type ATPase complex)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|rcsb pdb:6PE5|reactome:R-SCE-1222556|reactome:R-SCE-77387|reactome:R-SCE-917977|reactome:R-SCE-9639288|rcsb pdb:6PE4|dip:DIP-1737N	refseq:NP_010096.1|sgd:S000002344|mint:P17255|ensemblfungi:YDL185W(gene)|ensemblfungi:YDL185W_mRNA(transcript)|go:"GO:0000221"(vacuolar proton-transporting V-type ATPase, V1 domain)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0003677"(DNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006314"(intron homing)|go:"GO:0007035"(vacuolar acidification)|go:"GO:0012505"(endomembrane system)|go:"GO:0016539"(intein-mediated protein splicing)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0046933"(proton-transporting ATP synthase activity, rotational mechanism)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR000194(ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding)|interpro:IPR003586(Hedgehog/intein hint domain, C-terminal)|interpro:IPR003587(Hedgehog/intein hint, N-terminal)|interpro:IPR004042(Intein DOD homing endonuclease)|interpro:IPR004100(ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal)|interpro:IPR006141(Intein splicing site)|interpro:IPR006142(Intein)|interpro:IPR007868(Hom-end-associated Hint)|interpro:IPR007869(Homing endonuclease)|interpro:IPR020003|interpro:IPR022878|interpro:IPR023366|interpro:IPR027417|interpro:IPR027434|interpro:IPR030934|interpro:IPR031686|interpro:IPR036121|interpro:IPR036844|rcsb pdb:1DFA|rcsb pdb:1EF0|rcsb pdb:1GPP|rcsb pdb:1JVA|rcsb pdb:1LWS|rcsb pdb:1LWT|rcsb pdb:1UM2|rcsb pdb:1VDE|rcsb pdb:3J9T|rcsb pdb:3J9U|rcsb pdb:3J9V|rcsb pdb:5BW9|rcsb pdb:5D80|rcsb pdb:5VOX|rcsb pdb:5VOY|rcsb pdb:5VOZ|reactome:R-SCE-1222556|reactome:R-SCE-77387|reactome:R-SCE-917977|reactome:R-SCE-9639288|interpro:IPR024034|dip:DIP-2293N	-	crc64:53A19450CAF35632	crc64:2A4C65D2F59426FD	figure legend:Figure 1, Extended Data Figure 4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/01/28	2020/02/06	rogid:Ux3Cd8Fl9t/GGgcKAzJevZQFWnE559292	rogid:YdmGZxIMX2IXMHC4EO85uOAf1Hg559292	rigid:9zXv+zR9pGSxm35h9wU0XmDOLhg	false	-	flag tag:c-c	1	3	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P32366	uniprotkb:P16140	intact:EBI-20201|uniprotkb:D6VZ81|ensemblfungi:YLR447C	intact:EBI-20254|uniprotkb:P32123|uniprotkb:D6VQC4|ensemblfungi:YBR127C	psi-mi:va0d_yeast(display_long)|uniprotkb:VMA6(gene name)|psi-mi:VMA6(display_short)|uniprotkb:YLR447C(locus name)|uniprotkb:L9324.8(orf name)|uniprotkb:Vacuolar proton pump subunit d(gene name synonym)|uniprotkb:V-ATPase 39 kDa subunit(gene name synonym)|uniprotkb:V-ATPase subunit M39(gene name synonym)	psi-mi:vatb_yeast(display_long)|uniprotkb:VMA2(gene name)|psi-mi:VMA2(display_short)|uniprotkb:Vacuolar proton pump subunit B(gene name synonym)|uniprotkb:V-ATPase 57 kDa subunit(gene name synonym)|uniprotkb:VAT2(gene name synonym)|uniprotkb:YBR1002(orf name)|uniprotkb:YBR127C(locus name)	psi-mi:"MI:2338"(electron tomography)	Zhao et al. (2015)	imex:IM-27701|pubmed:25971514	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-25419483|wwpdb:3J9T|wwpdb:3J9U|wwpdb:3J9V|emdb:EMD-6284|emdb:EMD-6285|emdb:EMD-6286|imex:IM-27701-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000004439|refseq:NP_013552.3|mint:P32366|interpro:IPR016727(ATPase, V0 complex, subunit D)|interpro:IPR035067|interpro:IPR036079|interpro:IPR044911|rcsb pdb:3J9T|rcsb pdb:3J9U|rcsb pdb:3J9V|rcsb pdb:5TJ5|rcsb pdb:5VOX|rcsb pdb:5VOY|rcsb pdb:5VOZ|rcsb pdb:6C6L|rcsb pdb:6M0R|rcsb pdb:6M0S|rcsb pdb:6O7T|rcsb pdb:6O7U|interpro:IPR002843(ATPase, V0/A0 complex, subunit C/D)|rcsb pdb:6O7V|rcsb pdb:6O7W|rcsb pdb:6O7X|ensemblfungi:YLR447C(gene)|ensemblfungi:YLR447C_mRNA(transcript)|go:"GO:0000220"(vacuolar proton-transporting V-type ATPase, V0 domain)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0007034"(vacuolar transport)|go:"GO:0007035"(vacuolar acidification)|go:"GO:0016471"(vacuolar proton-transporting V-type ATPase complex)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|rcsb pdb:6PE5|reactome:R-SCE-1222556|reactome:R-SCE-77387|reactome:R-SCE-917977|reactome:R-SCE-9639288|rcsb pdb:6PE4|dip:DIP-1737N	sgd:S000000331|refseq:NP_009685.3|ensemblfungi:YBR127C(gene)|ensemblfungi:YBR127C_mRNA(transcript)|go:"GO:0000221"(vacuolar proton-transporting V-type ATPase, V1 domain)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0000425"(pexophagy)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007035"(vacuolar acidification)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016787"(hydrolase activity)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:0055085"(transmembrane transport)|go:"GO:1902906"(proteasome storage granule assembly)|go:"GO:1990816"(vacuole-mitochondrion membrane contact site)|interpro:IPR000194(ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding)|interpro:IPR004100(ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal)|interpro:IPR005723(ATPase, V1 complex, subunit B)|interpro:IPR020003|interpro:IPR022879|interpro:IPR027417|rcsb pdb:3J9T|rcsb pdb:3J9U|rcsb pdb:3J9V|rcsb pdb:5BW9|rcsb pdb:5D80|rcsb pdb:5VOX|rcsb pdb:5VOY|rcsb pdb:5VOZ|rcsb pdb:6O7V|rcsb pdb:6O7W|rcsb pdb:6O7X|reactome:R-SCE-1222556|reactome:R-SCE-77387|reactome:R-SCE-917977|reactome:R-SCE-9639288|dip:DIP-2292N|mint:P16140	-	crc64:53A19450CAF35632	crc64:02A7DEC571EFF7C2	figure legend:Figure 1, Extended Data Figure 4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/01/28	2020/02/06	rogid:Ux3Cd8Fl9t/GGgcKAzJevZQFWnE559292	rogid:plrXuzL+4el/8brAJsClEbg+p0E559292	rigid:9zXv+zR9pGSxm35h9wU0XmDOLhg	false	-	-	1	3	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P32366	uniprotkb:P31412	intact:EBI-20201|uniprotkb:D6VZ81|ensemblfungi:YLR447C	intact:EBI-20260|uniprotkb:D6VXK7|ensemblfungi:YKL080W	psi-mi:va0d_yeast(display_long)|uniprotkb:VMA6(gene name)|psi-mi:VMA6(display_short)|uniprotkb:YLR447C(locus name)|uniprotkb:L9324.8(orf name)|uniprotkb:Vacuolar proton pump subunit d(gene name synonym)|uniprotkb:V-ATPase 39 kDa subunit(gene name synonym)|uniprotkb:V-ATPase subunit M39(gene name synonym)	psi-mi:vatc_yeast(display_long)|uniprotkb:VMA5(gene name)|psi-mi:VMA5(display_short)|uniprotkb:VAT3(gene name synonym)|uniprotkb:VATC(gene name synonym)|uniprotkb:YKL410(orf name)|uniprotkb:YKL080W(locus name)|uniprotkb:Vacuolar proton pump subunit C(gene name synonym)|uniprotkb:V-ATPase 42 kDa subunit(gene name synonym)	psi-mi:"MI:2338"(electron tomography)	Zhao et al. (2015)	imex:IM-27701|pubmed:25971514	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-25419483|wwpdb:3J9T|wwpdb:3J9U|wwpdb:3J9V|emdb:EMD-6284|emdb:EMD-6285|emdb:EMD-6286|imex:IM-27701-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000004439|refseq:NP_013552.3|mint:P32366|interpro:IPR016727(ATPase, V0 complex, subunit D)|interpro:IPR035067|interpro:IPR036079|interpro:IPR044911|rcsb pdb:3J9T|rcsb pdb:3J9U|rcsb pdb:3J9V|rcsb pdb:5TJ5|rcsb pdb:5VOX|rcsb pdb:5VOY|rcsb pdb:5VOZ|rcsb pdb:6C6L|rcsb pdb:6M0R|rcsb pdb:6M0S|rcsb pdb:6O7T|rcsb pdb:6O7U|interpro:IPR002843(ATPase, V0/A0 complex, subunit C/D)|rcsb pdb:6O7V|rcsb pdb:6O7W|rcsb pdb:6O7X|ensemblfungi:YLR447C(gene)|ensemblfungi:YLR447C_mRNA(transcript)|go:"GO:0000220"(vacuolar proton-transporting V-type ATPase, V0 domain)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0007034"(vacuolar transport)|go:"GO:0007035"(vacuolar acidification)|go:"GO:0016471"(vacuolar proton-transporting V-type ATPase complex)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|rcsb pdb:6PE5|reactome:R-SCE-1222556|reactome:R-SCE-77387|reactome:R-SCE-917977|reactome:R-SCE-9639288|rcsb pdb:6PE4|dip:DIP-1737N	refseq:NP_012843.1|sgd:S000001563|ensemblfungi:YKL080W(gene)|ensemblfungi:YKL080W_mRNA(transcript)|go:"GO:0000221"(vacuolar proton-transporting V-type ATPase, V1 domain)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0005524"(ATP binding)|go:"GO:0007035"(vacuolar acidification)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|interpro:IPR004907(ATPase, V1 complex, subunit C)|interpro:IPR036132|rcsb pdb:1U7L|rcsb pdb:3J9T|rcsb pdb:3J9U|rcsb pdb:3J9V|rcsb pdb:4DL0|rcsb pdb:4EFA|rcsb pdb:5VOX|rcsb pdb:5VOY|rcsb pdb:5VOZ|rcsb pdb:6O7V|rcsb pdb:6O7W|rcsb pdb:6O7X|reactome:R-SCE-1222556|reactome:R-SCE-77387|reactome:R-SCE-917977|reactome:R-SCE-9639288|dip:DIP-4701N|mint:P31412	-	crc64:53A19450CAF35632	crc64:0CD1B814046C377E	figure legend:Figure 1, Extended Data Figure 4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/01/28	2020/02/06	rogid:Ux3Cd8Fl9t/GGgcKAzJevZQFWnE559292	rogid:NBI0upCB5yxAyMQgccBcLhjZk8s559292	rigid:9zXv+zR9pGSxm35h9wU0XmDOLhg	false	-	-	1	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P32366	uniprotkb:P32610	intact:EBI-20201|uniprotkb:D6VZ81|ensemblfungi:YLR447C	intact:EBI-20264|uniprotkb:D3DLJ9|ensemblfungi:YEL051W	psi-mi:va0d_yeast(display_long)|uniprotkb:VMA6(gene name)|psi-mi:VMA6(display_short)|uniprotkb:YLR447C(locus name)|uniprotkb:L9324.8(orf name)|uniprotkb:Vacuolar proton pump subunit d(gene name synonym)|uniprotkb:V-ATPase 39 kDa subunit(gene name synonym)|uniprotkb:V-ATPase subunit M39(gene name synonym)	psi-mi:vatd_yeast(display_long)|uniprotkb:VMA8(gene name)|psi-mi:VMA8(display_short)|uniprotkb:YEL051W(locus name)|uniprotkb:SYGP-ORF11(orf name)|uniprotkb:Vacuolar proton pump subunit D(gene name synonym)	psi-mi:"MI:2338"(electron tomography)	Zhao et al. (2015)	imex:IM-27701|pubmed:25971514	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-25419483|wwpdb:3J9T|wwpdb:3J9U|wwpdb:3J9V|emdb:EMD-6284|emdb:EMD-6285|emdb:EMD-6286|imex:IM-27701-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000004439|refseq:NP_013552.3|mint:P32366|interpro:IPR016727(ATPase, V0 complex, subunit D)|interpro:IPR035067|interpro:IPR036079|interpro:IPR044911|rcsb pdb:3J9T|rcsb pdb:3J9U|rcsb pdb:3J9V|rcsb pdb:5TJ5|rcsb pdb:5VOX|rcsb pdb:5VOY|rcsb pdb:5VOZ|rcsb pdb:6C6L|rcsb pdb:6M0R|rcsb pdb:6M0S|rcsb pdb:6O7T|rcsb pdb:6O7U|interpro:IPR002843(ATPase, V0/A0 complex, subunit C/D)|rcsb pdb:6O7V|rcsb pdb:6O7W|rcsb pdb:6O7X|ensemblfungi:YLR447C(gene)|ensemblfungi:YLR447C_mRNA(transcript)|go:"GO:0000220"(vacuolar proton-transporting V-type ATPase, V0 domain)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0007034"(vacuolar transport)|go:"GO:0007035"(vacuolar acidification)|go:"GO:0016471"(vacuolar proton-transporting V-type ATPase complex)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|rcsb pdb:6PE5|reactome:R-SCE-1222556|reactome:R-SCE-77387|reactome:R-SCE-917977|reactome:R-SCE-9639288|rcsb pdb:6PE4|dip:DIP-1737N	refseq:NP_010863.1|sgd:S000000777|ensemblfungi:YEL051W(gene)|ensemblfungi:YEL051W_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0005774"(vacuolar membrane)|go:"GO:0007035"(vacuolar acidification)|go:"GO:0016471"(vacuolar proton-transporting V-type ATPase complex)|go:"GO:0033176"(proton-transporting V-type ATPase complex)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR002699(ATPase, V1/A1 complex, subunit D)|rcsb pdb:3J9T|rcsb pdb:3J9U|rcsb pdb:3J9V|rcsb pdb:4RND|rcsb pdb:5BW9|rcsb pdb:5D80|rcsb pdb:5VOX|rcsb pdb:5VOY|rcsb pdb:5VOZ|rcsb pdb:6O7V|rcsb pdb:6O7W|rcsb pdb:6O7X|reactome:R-SCE-1222556|reactome:R-SCE-6798695|reactome:R-SCE-77387|reactome:R-SCE-917977|reactome:R-SCE-9639288|dip:DIP-2959N|mint:P32610	-	crc64:53A19450CAF35632	crc64:FDE93E1FAF0AEC5B	figure legend:Figure 1, Extended Data Figure 4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/01/28	2020/02/06	rogid:Ux3Cd8Fl9t/GGgcKAzJevZQFWnE559292	rogid:rrwRno7lCnDeTNwawONkGwV8Hkg559292	rigid:9zXv+zR9pGSxm35h9wU0XmDOLhg	false	-	-	1	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P32366	uniprotkb:P22203	intact:EBI-20201|uniprotkb:D6VZ81|ensemblfungi:YLR447C	intact:EBI-20268|uniprotkb:D6W328|ensemblfungi:YOR332W	psi-mi:va0d_yeast(display_long)|uniprotkb:VMA6(gene name)|psi-mi:VMA6(display_short)|uniprotkb:YLR447C(locus name)|uniprotkb:L9324.8(orf name)|uniprotkb:Vacuolar proton pump subunit d(gene name synonym)|uniprotkb:V-ATPase 39 kDa subunit(gene name synonym)|uniprotkb:V-ATPase subunit M39(gene name synonym)	psi-mi:vate_yeast(display_long)|uniprotkb:VMA4(gene name)|psi-mi:VMA4(display_short)|uniprotkb:VAT5(gene name synonym)|uniprotkb:O6241(orf name)|uniprotkb:YOR332W(locus name)|uniprotkb:Vacuolar proton pump subunit E(gene name synonym)|uniprotkb:V-ATPase 27 kDa subunit(gene name synonym)	psi-mi:"MI:2338"(electron tomography)	Zhao et al. (2015)	imex:IM-27701|pubmed:25971514	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-25419483|wwpdb:3J9T|wwpdb:3J9U|wwpdb:3J9V|emdb:EMD-6284|emdb:EMD-6285|emdb:EMD-6286|imex:IM-27701-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000004439|refseq:NP_013552.3|mint:P32366|interpro:IPR016727(ATPase, V0 complex, subunit D)|interpro:IPR035067|interpro:IPR036079|interpro:IPR044911|rcsb pdb:3J9T|rcsb pdb:3J9U|rcsb pdb:3J9V|rcsb pdb:5TJ5|rcsb pdb:5VOX|rcsb pdb:5VOY|rcsb pdb:5VOZ|rcsb pdb:6C6L|rcsb pdb:6M0R|rcsb pdb:6M0S|rcsb pdb:6O7T|rcsb pdb:6O7U|interpro:IPR002843(ATPase, V0/A0 complex, subunit C/D)|rcsb pdb:6O7V|rcsb pdb:6O7W|rcsb pdb:6O7X|ensemblfungi:YLR447C(gene)|ensemblfungi:YLR447C_mRNA(transcript)|go:"GO:0000220"(vacuolar proton-transporting V-type ATPase, V0 domain)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0007034"(vacuolar transport)|go:"GO:0007035"(vacuolar acidification)|go:"GO:0016471"(vacuolar proton-transporting V-type ATPase complex)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|rcsb pdb:6PE5|reactome:R-SCE-1222556|reactome:R-SCE-77387|reactome:R-SCE-917977|reactome:R-SCE-9639288|rcsb pdb:6PE4|dip:DIP-1737N	reactome:R-SCE-77387|sgd:S000005859|reactome:R-SCE-1222556|refseq:NP_014977.3|ensemblfungi:YOR332W(gene)|ensemblfungi:YOR332W_mRNA(transcript)|go:"GO:0000221"(vacuolar proton-transporting V-type ATPase, V1 domain)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0007035"(vacuolar acidification)|go:"GO:0008553"(P-type proton-exporting transporter activity)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|interpro:IPR002842(ATPase, V1/A1 complex, subunit E)|interpro:IPR038495|rcsb pdb:2KZ9|rcsb pdb:3J9T|rcsb pdb:3J9U|rcsb pdb:3J9V|rcsb pdb:4DL0|rcsb pdb:4EFA|rcsb pdb:5BW9|rcsb pdb:5D80|rcsb pdb:5VOX|rcsb pdb:5VOY|rcsb pdb:5VOZ|rcsb pdb:6O7V|rcsb pdb:6O7W|rcsb pdb:6O7X|dip:DIP-4595N|reactome:R-SCE-917977|reactome:R-SCE-9639288	-	crc64:53A19450CAF35632	crc64:7AC5169FF7E5A39C	figure legend:Figure 1, Extended Data Figure 4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/01/28	2020/02/06	rogid:Ux3Cd8Fl9t/GGgcKAzJevZQFWnE559292	rogid:g5fE3fwOSqcB4fXde9P8p6BD4T8559292	rigid:9zXv+zR9pGSxm35h9wU0XmDOLhg	false	-	-	1	3	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P32366	uniprotkb:P39111	intact:EBI-20201|uniprotkb:D6VZ81|ensemblfungi:YLR447C	intact:EBI-20272|uniprotkb:D6VUF5|ensemblfungi:YGR020C	psi-mi:va0d_yeast(display_long)|uniprotkb:VMA6(gene name)|psi-mi:VMA6(display_short)|uniprotkb:YLR447C(locus name)|uniprotkb:L9324.8(orf name)|uniprotkb:Vacuolar proton pump subunit d(gene name synonym)|uniprotkb:V-ATPase 39 kDa subunit(gene name synonym)|uniprotkb:V-ATPase subunit M39(gene name synonym)	psi-mi:vatf_yeast(display_long)|uniprotkb:VMA7(gene name)|psi-mi:VMA7(display_short)|uniprotkb:YGR020C(locus name)|uniprotkb:Vacuolar proton pump subunit F(gene name synonym)|uniprotkb:V-ATPase 14 kDa subunit(gene name synonym)	psi-mi:"MI:2338"(electron tomography)	Zhao et al. (2015)	imex:IM-27701|pubmed:25971514	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-25419483|wwpdb:3J9T|wwpdb:3J9U|wwpdb:3J9V|emdb:EMD-6284|emdb:EMD-6285|emdb:EMD-6286|imex:IM-27701-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000004439|refseq:NP_013552.3|mint:P32366|interpro:IPR016727(ATPase, V0 complex, subunit D)|interpro:IPR035067|interpro:IPR036079|interpro:IPR044911|rcsb pdb:3J9T|rcsb pdb:3J9U|rcsb pdb:3J9V|rcsb pdb:5TJ5|rcsb pdb:5VOX|rcsb pdb:5VOY|rcsb pdb:5VOZ|rcsb pdb:6C6L|rcsb pdb:6M0R|rcsb pdb:6M0S|rcsb pdb:6O7T|rcsb pdb:6O7U|interpro:IPR002843(ATPase, V0/A0 complex, subunit C/D)|rcsb pdb:6O7V|rcsb pdb:6O7W|rcsb pdb:6O7X|ensemblfungi:YLR447C(gene)|ensemblfungi:YLR447C_mRNA(transcript)|go:"GO:0000220"(vacuolar proton-transporting V-type ATPase, V0 domain)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0007034"(vacuolar transport)|go:"GO:0007035"(vacuolar acidification)|go:"GO:0016471"(vacuolar proton-transporting V-type ATPase complex)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|rcsb pdb:6PE5|reactome:R-SCE-1222556|reactome:R-SCE-77387|reactome:R-SCE-917977|reactome:R-SCE-9639288|rcsb pdb:6PE4|dip:DIP-1737N	refseq:NP_011534.1|sgd:S000003252|ensemblfungi:YGR020C(gene)|ensemblfungi:YGR020C_mRNA(transcript)|go:"GO:0000221"(vacuolar proton-transporting V-type ATPase, V1 domain)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0007035"(vacuolar acidification)|go:"GO:0016020"(membrane)|go:"GO:0042625"(ATPase-coupled ion transmembrane transporter activity)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|interpro:IPR005772(ATPase, V1 complex, subunit F, eukaryotic)|interpro:IPR008218(ATPase, V1/A1 complex, subunit F)|interpro:IPR036906|rcsb pdb:3J9T|rcsb pdb:3J9U|rcsb pdb:3J9V|rcsb pdb:4IX9|rcsb pdb:4RND|rcsb pdb:5D80|rcsb pdb:5VOX|rcsb pdb:5VOY|rcsb pdb:5VOZ|rcsb pdb:6O7V|rcsb pdb:6O7W|rcsb pdb:6O7X|reactome:R-SCE-1222556|reactome:R-SCE-77387|reactome:R-SCE-917977|reactome:R-SCE-9639288|dip:DIP-2077N|mint:P39111	-	crc64:53A19450CAF35632	crc64:D21EC0980EB99DFF	figure legend:Figure 1, Extended Data Figure 4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/01/28	2020/02/06	rogid:Ux3Cd8Fl9t/GGgcKAzJevZQFWnE559292	rogid:VtthQl2jj9fpjv3psX0YUNbIAKU559292	rigid:9zXv+zR9pGSxm35h9wU0XmDOLhg	false	-	-	1	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P32366	uniprotkb:P48836	intact:EBI-20201|uniprotkb:D6VZ81|ensemblfungi:YLR447C	intact:EBI-20276|uniprotkb:D3DKY7|ensemblfungi:YHR039C-A	psi-mi:va0d_yeast(display_long)|uniprotkb:VMA6(gene name)|psi-mi:VMA6(display_short)|uniprotkb:YLR447C(locus name)|uniprotkb:L9324.8(orf name)|uniprotkb:Vacuolar proton pump subunit d(gene name synonym)|uniprotkb:V-ATPase 39 kDa subunit(gene name synonym)|uniprotkb:V-ATPase subunit M39(gene name synonym)	psi-mi:vatg_yeast(display_long)|uniprotkb:VMA10(gene name)|psi-mi:VMA10(display_short)|uniprotkb:YHR039C-A(locus name)|uniprotkb:YHR039BC(orf name)|uniprotkb:YHR039C-B(orf name)|uniprotkb:Vacuolar proton pump subunit G(gene name synonym)|uniprotkb:V-ATPase 13 kDa subunit(gene name synonym)	psi-mi:"MI:2338"(electron tomography)	Zhao et al. (2015)	imex:IM-27701|pubmed:25971514	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-25419483|wwpdb:3J9T|wwpdb:3J9U|wwpdb:3J9V|emdb:EMD-6284|emdb:EMD-6285|emdb:EMD-6286|imex:IM-27701-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000004439|refseq:NP_013552.3|mint:P32366|interpro:IPR016727(ATPase, V0 complex, subunit D)|interpro:IPR035067|interpro:IPR036079|interpro:IPR044911|rcsb pdb:3J9T|rcsb pdb:3J9U|rcsb pdb:3J9V|rcsb pdb:5TJ5|rcsb pdb:5VOX|rcsb pdb:5VOY|rcsb pdb:5VOZ|rcsb pdb:6C6L|rcsb pdb:6M0R|rcsb pdb:6M0S|rcsb pdb:6O7T|rcsb pdb:6O7U|interpro:IPR002843(ATPase, V0/A0 complex, subunit C/D)|rcsb pdb:6O7V|rcsb pdb:6O7W|rcsb pdb:6O7X|ensemblfungi:YLR447C(gene)|ensemblfungi:YLR447C_mRNA(transcript)|go:"GO:0000220"(vacuolar proton-transporting V-type ATPase, V0 domain)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0007034"(vacuolar transport)|go:"GO:0007035"(vacuolar acidification)|go:"GO:0016471"(vacuolar proton-transporting V-type ATPase complex)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|rcsb pdb:6PE5|reactome:R-SCE-1222556|reactome:R-SCE-77387|reactome:R-SCE-917977|reactome:R-SCE-9639288|rcsb pdb:6PE4|dip:DIP-1737N	refseq:NP_011905.1|sgd:S000002100|ensemblfungi:YHR039C-A(gene)|ensemblfungi:YHR039C-A_mRNA(transcript)|go:"GO:0000221"(vacuolar proton-transporting V-type ATPase, V1 domain)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0007035"(vacuolar acidification)|go:"GO:0016471"(vacuolar proton-transporting V-type ATPase complex)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|interpro:IPR005124("Vacuolar (H+)-ATPase G subunit")|rcsb pdb:2K88|rcsb pdb:2KWY|rcsb pdb:3J9T|rcsb pdb:3J9U|rcsb pdb:3J9V|rcsb pdb:4DL0|rcsb pdb:4EFA|rcsb pdb:5BW9|rcsb pdb:5D80|rcsb pdb:5VOX|rcsb pdb:5VOY|rcsb pdb:5VOZ|rcsb pdb:6O7V|rcsb pdb:6O7W|rcsb pdb:6O7X|reactome:R-SCE-1222556|reactome:R-SCE-77387|reactome:R-SCE-917977|reactome:R-SCE-9639288|dip:DIP-2720N|mint:P48836	-	crc64:53A19450CAF35632	crc64:259660D440A933D0	figure legend:Figure 1, Extended Data Figure 4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/01/28	2020/02/06	rogid:Ux3Cd8Fl9t/GGgcKAzJevZQFWnE559292	rogid:386WeuS2dVB/D2DmtUc9J7YddHg559292	rigid:9zXv+zR9pGSxm35h9wU0XmDOLhg	false	-	-	1	3	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P32366	uniprotkb:P41807	intact:EBI-20201|uniprotkb:D6VZ81|ensemblfungi:YLR447C	intact:EBI-20281|uniprotkb:D6W446|ensemblfungi:YPR036W	psi-mi:va0d_yeast(display_long)|uniprotkb:VMA6(gene name)|psi-mi:VMA6(display_short)|uniprotkb:YLR447C(locus name)|uniprotkb:L9324.8(orf name)|uniprotkb:Vacuolar proton pump subunit d(gene name synonym)|uniprotkb:V-ATPase 39 kDa subunit(gene name synonym)|uniprotkb:V-ATPase subunit M39(gene name synonym)	psi-mi:vath_yeast(display_long)|uniprotkb:YP3085.02(orf name)|uniprotkb:VMA13(gene name)|psi-mi:VMA13(display_short)|uniprotkb:CLS11(gene name synonym)|uniprotkb:YPR036W(locus name)|uniprotkb:Vacuolar proton pump subunit H(gene name synonym)|uniprotkb:V-ATPase 54 kDa subunit(gene name synonym)	psi-mi:"MI:2338"(electron tomography)	Zhao et al. (2015)	imex:IM-27701|pubmed:25971514	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-25419483|wwpdb:3J9T|wwpdb:3J9U|wwpdb:3J9V|emdb:EMD-6284|emdb:EMD-6285|emdb:EMD-6286|imex:IM-27701-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000004439|refseq:NP_013552.3|mint:P32366|interpro:IPR016727(ATPase, V0 complex, subunit D)|interpro:IPR035067|interpro:IPR036079|interpro:IPR044911|rcsb pdb:3J9T|rcsb pdb:3J9U|rcsb pdb:3J9V|rcsb pdb:5TJ5|rcsb pdb:5VOX|rcsb pdb:5VOY|rcsb pdb:5VOZ|rcsb pdb:6C6L|rcsb pdb:6M0R|rcsb pdb:6M0S|rcsb pdb:6O7T|rcsb pdb:6O7U|interpro:IPR002843(ATPase, V0/A0 complex, subunit C/D)|rcsb pdb:6O7V|rcsb pdb:6O7W|rcsb pdb:6O7X|ensemblfungi:YLR447C(gene)|ensemblfungi:YLR447C_mRNA(transcript)|go:"GO:0000220"(vacuolar proton-transporting V-type ATPase, V0 domain)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0007034"(vacuolar transport)|go:"GO:0007035"(vacuolar acidification)|go:"GO:0016471"(vacuolar proton-transporting V-type ATPase complex)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|rcsb pdb:6PE5|reactome:R-SCE-1222556|reactome:R-SCE-77387|reactome:R-SCE-917977|reactome:R-SCE-9639288|rcsb pdb:6PE4|dip:DIP-1737N	refseq:NP_015361.1|sgd:S000006240|go:"GO:0007035"(vacuolar acidification)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|interpro:IPR004908(ATPase, V1 complex, subunit H)|interpro:IPR011987(ATPase, V1 complex, subunit H, C-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR038497|rcsb pdb:1HO8|rcsb pdb:3J9T|rcsb pdb:3J9U|rcsb pdb:3J9V|rcsb pdb:5BW9|rcsb pdb:5D80|rcsb pdb:5VOX|rcsb pdb:5VOY|rcsb pdb:5VOZ|rcsb pdb:6O7V|rcsb pdb:6O7W|rcsb pdb:6O7X|reactome:R-SCE-1222556|reactome:R-SCE-77387|reactome:R-SCE-917977|reactome:R-SCE-9639288|ensemblfungi:YPR036W(gene)|ensemblfungi:YPR036W_mRNA(transcript)|go:"GO:0000221"(vacuolar proton-transporting V-type ATPase, V1 domain)|go:"GO:0000329"(fungal-type vacuole membrane)|dip:DIP-6640N|mint:P41807	-	crc64:53A19450CAF35632	crc64:54131FF9C2C87594	figure legend:Figure 1, Extended Data Figure 4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/01/28	2020/02/06	rogid:Ux3Cd8Fl9t/GGgcKAzJevZQFWnE559292	rogid:kEXWvOsnTk0WdgGOny+mufz4lTo559292	rigid:9zXv+zR9pGSxm35h9wU0XmDOLhg	false	-	-	1	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P32366	uniprotkb:P25515	intact:EBI-20201|uniprotkb:D6VZ81|ensemblfungi:YLR447C	intact:EBI-7739233|ensemblfungi:YEL027W|intact:MINT-1353979|uniprotkb:D3DLM1	psi-mi:va0d_yeast(display_long)|uniprotkb:VMA6(gene name)|psi-mi:VMA6(display_short)|uniprotkb:YLR447C(locus name)|uniprotkb:L9324.8(orf name)|uniprotkb:Vacuolar proton pump subunit d(gene name synonym)|uniprotkb:V-ATPase 39 kDa subunit(gene name synonym)|uniprotkb:V-ATPase subunit M39(gene name synonym)	psi-mi:vatl1_yeast(display_long)|uniprotkb:VMA3(gene name)|psi-mi:VMA3(display_short)|uniprotkb:CLS7(gene name synonym)|uniprotkb:CUP5(gene name synonym)|uniprotkb:GEF2(gene name synonym)|uniprotkb:YEL027W(locus name)|uniprotkb:Vacuolar proton pump c subunit(gene name synonym)|uniprotkb:V-ATPase 16 kDa proteolipid subunit 1(gene name synonym)|uniprotkb:Guanine nucleotide exchange factor 2(gene name synonym)	psi-mi:"MI:2338"(electron tomography)	Zhao et al. (2015)	imex:IM-27701|pubmed:25971514	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-25419483|wwpdb:3J9T|wwpdb:3J9U|wwpdb:3J9V|emdb:EMD-6284|emdb:EMD-6285|emdb:EMD-6286|imex:IM-27701-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000004439|refseq:NP_013552.3|mint:P32366|interpro:IPR016727(ATPase, V0 complex, subunit D)|interpro:IPR035067|interpro:IPR036079|interpro:IPR044911|rcsb pdb:3J9T|rcsb pdb:3J9U|rcsb pdb:3J9V|rcsb pdb:5TJ5|rcsb pdb:5VOX|rcsb pdb:5VOY|rcsb pdb:5VOZ|rcsb pdb:6C6L|rcsb pdb:6M0R|rcsb pdb:6M0S|rcsb pdb:6O7T|rcsb pdb:6O7U|interpro:IPR002843(ATPase, V0/A0 complex, subunit C/D)|rcsb pdb:6O7V|rcsb pdb:6O7W|rcsb pdb:6O7X|ensemblfungi:YLR447C(gene)|ensemblfungi:YLR447C_mRNA(transcript)|go:"GO:0000220"(vacuolar proton-transporting V-type ATPase, V0 domain)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0007034"(vacuolar transport)|go:"GO:0007035"(vacuolar acidification)|go:"GO:0016471"(vacuolar proton-transporting V-type ATPase complex)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|rcsb pdb:6PE5|reactome:R-SCE-1222556|reactome:R-SCE-77387|reactome:R-SCE-917977|reactome:R-SCE-9639288|rcsb pdb:6PE4|dip:DIP-1737N	interpro:IPR002379(ATPase, F0/V0 complex, subunit C)|interpro:IPR011555(ATPase, V0 complex, proteolipid subunit C, eukaryotic)|interpro:IPR035921|rcsb pdb:3J9T|rcsb pdb:3J9U|rcsb pdb:3J9V|rcsb pdb:5TJ5|rcsb pdb:5VOX|rcsb pdb:5VOY|rcsb pdb:5VOZ|rcsb pdb:6C6L|rcsb pdb:6M0R|rcsb pdb:6M0S|rcsb pdb:6O7T|rcsb pdb:6O7U|rcsb pdb:6O7V|rcsb pdb:6O7W|rcsb pdb:6O7X|rcsb pdb:6PE4|rcsb pdb:6PE5|reactome:R-SCE-1222556|reactome:R-SCE-6798695|reactome:R-SCE-77387|reactome:R-SCE-917977|reactome:R-SCE-9639288|ensemblfungi:YEL027W(gene)|ensemblfungi:YEL027W_mRNA(transcript)|go:"GO:0000220"(vacuolar proton-transporting V-type ATPase, V0 domain)|go:"GO:0005774"(vacuolar membrane)|go:"GO:0006623"(protein targeting to vacuole)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0006897"(endocytosis)|go:"GO:0007033"(vacuole organization)|go:"GO:0007035"(vacuolar acidification)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR000245(ATPase, V0 complex, proteolipid subunit C,)|sgd:S000000753|mint:P25515|refseq:NP_010887.3|dip:DIP-8123N	-	crc64:53A19450CAF35632	crc64:FB8A142FFA1FA964|comment:mint|function:Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. It is an electrogenic proton pump that generates a proton motive force of 180 mv, inside positive and acidic, in the vacuolar membrane vesicles	figure legend:Figure 1, Extended Data Figure 4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/01/28	2020/02/06	rogid:Ux3Cd8Fl9t/GGgcKAzJevZQFWnE559292	rogid:MAXfIOCwZyeV4Vy1T0eKqIbS4ZQ559292	rigid:9zXv+zR9pGSxm35h9wU0XmDOLhg	false	-	-	1	10	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P32366	uniprotkb:P32563	intact:EBI-20201|uniprotkb:D6VZ81|ensemblfungi:YLR447C	intact:EBI-20455|uniprotkb:D6W2X0|ensemblfungi:YOR270C	psi-mi:va0d_yeast(display_long)|uniprotkb:VMA6(gene name)|psi-mi:VMA6(display_short)|uniprotkb:YLR447C(locus name)|uniprotkb:L9324.8(orf name)|uniprotkb:Vacuolar proton pump subunit d(gene name synonym)|uniprotkb:V-ATPase 39 kDa subunit(gene name synonym)|uniprotkb:V-ATPase subunit M39(gene name synonym)	psi-mi:vph1_yeast(display_long)|uniprotkb:VPH1(gene name)|psi-mi:VPH1(display_short)|uniprotkb:Vacuolar proton pump a subunit(gene name synonym)|uniprotkb:V-ATPase 95 kDa subunit(gene name synonym)|uniprotkb:Vacuolar pH protein 1(gene name synonym)|uniprotkb:Vacuolar proton translocating ATPase subunit a 1(gene name synonym)|uniprotkb:YOR270C(locus name)	psi-mi:"MI:2338"(electron tomography)	Zhao et al. (2015)	imex:IM-27701|pubmed:25971514	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-25419483|wwpdb:3J9T|wwpdb:3J9U|wwpdb:3J9V|emdb:EMD-6284|emdb:EMD-6285|emdb:EMD-6286|imex:IM-27701-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000004439|refseq:NP_013552.3|mint:P32366|interpro:IPR016727(ATPase, V0 complex, subunit D)|interpro:IPR035067|interpro:IPR036079|interpro:IPR044911|rcsb pdb:3J9T|rcsb pdb:3J9U|rcsb pdb:3J9V|rcsb pdb:5TJ5|rcsb pdb:5VOX|rcsb pdb:5VOY|rcsb pdb:5VOZ|rcsb pdb:6C6L|rcsb pdb:6M0R|rcsb pdb:6M0S|rcsb pdb:6O7T|rcsb pdb:6O7U|interpro:IPR002843(ATPase, V0/A0 complex, subunit C/D)|rcsb pdb:6O7V|rcsb pdb:6O7W|rcsb pdb:6O7X|ensemblfungi:YLR447C(gene)|ensemblfungi:YLR447C_mRNA(transcript)|go:"GO:0000220"(vacuolar proton-transporting V-type ATPase, V0 domain)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0007034"(vacuolar transport)|go:"GO:0007035"(vacuolar acidification)|go:"GO:0016471"(vacuolar proton-transporting V-type ATPase complex)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|rcsb pdb:6PE5|reactome:R-SCE-1222556|reactome:R-SCE-77387|reactome:R-SCE-917977|reactome:R-SCE-9639288|rcsb pdb:6PE4|dip:DIP-1737N	sgd:S000005796|refseq:NP_014913.3|ensemblfungi:YOR270C(gene)|ensemblfungi:YOR270C_mRNA(transcript)|go:"GO:0000220"(vacuolar proton-transporting V-type ATPase, V0 domain)|go:"GO:0000324"(fungal-type vacuole)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0006797"(polyphosphate metabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016471"(vacuolar proton-transporting V-type ATPase complex)|go:"GO:0034622"|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:0051117"(ATPase binding)|go:"GO:0071469"(cellular response to alkaline pH)|go:"GO:0071474"(cellular hyperosmotic response)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR002490(ATPase, V0/A0 complex, 116-kDa subunit)|interpro:IPR026028|rcsb pdb:2JTW|rcsb pdb:2NVJ|rcsb pdb:2RPW|rcsb pdb:3J9T|go:"GO:0007035"(vacuolar acidification)|rcsb pdb:3J9U|rcsb pdb:3J9V|rcsb pdb:5I1M|rcsb pdb:5TJ5|rcsb pdb:5VOX|rcsb pdb:5VOY|rcsb pdb:5VOZ|rcsb pdb:6C6L|rcsb pdb:6HH0|rcsb pdb:6M0R|rcsb pdb:6M0S|rcsb pdb:6O7T|rcsb pdb:6PE4|rcsb pdb:6PE5|reactome:R-SCE-1222556|reactome:R-SCE-6798695|reactome:R-SCE-77387|reactome:R-SCE-917977|reactome:R-SCE-9639288|dip:DIP-2960N|mint:P32563	-	crc64:53A19450CAF35632	crc64:77709A914410CD4D	figure legend:Figure 1, Extended Data Figure 4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/01/28	2020/02/06	rogid:Ux3Cd8Fl9t/GGgcKAzJevZQFWnE559292	rogid:c+aKW/ZUnBlGW7ZqOLD/0mpICdQ559292	rigid:9zXv+zR9pGSxm35h9wU0XmDOLhg	false	-	-	1	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)