#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q19QW5 uniprotkb:Q13287 intact:EBI-25493595|uniprotkb:J9TC54 intact:EBI-372942|uniprotkb:Q53TI8|intact:EBI-10174268|uniprotkb:Q8WTW2|uniprotkb:Q9BVE5|uniprotkb:B5BU69|ensembl:ENSP00000243346 psi-mi:q19qw5_sars(display_long)|uniprotkb:ORF6(gene name)|psi-mi:ORF6(display_short)|uniprotkb:sars6(gene name synonym) psi-mi:nmi_human(display_long)|uniprotkb:NMI(gene name)|psi-mi:NMI(display_short)|uniprotkb:N-myc and STAT interactor(gene name synonym) psi-mi:"MI:0018"(two hybrid) Cheng et al. (2015) pubmed:25907116|imex:IM-28094 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-25649488|imex:IM-28094-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016020"(membrane)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044178"(host cell Golgi membrane)|interpro:IPR022736|refseq:NP_828856.1 refseq:NP_004679.2|refseq:XP_005246998.1|ensembl:ENSG00000123609(gene)|ensembl:ENST00000243346(transcript)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009615"(response to virus)|go:"GO:0016020"(membrane)|go:"GO:0032687"(negative regulation of interferon-alpha production)|go:"GO:0032688"(negative regulation of interferon-beta production)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045824"(negative regulation of innate immune response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902524"(positive regulation of protein K48-linked ubiquitination)|interpro:IPR009909(Nmi/IFP 35)|interpro:IPR009938(Interferon-induced 35 kDa, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033527|mint:Q13287|refseq:XP_016860736.1 - - - figure legend:Table 2|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/06/17 2020/06/17 rogid:FbI4KIsNxOBCtk9JMPiabQsxtXM694009 rogid:qOkzIuloaWW88apb9JH2DT/Bnuk9606 rigid:6uQXnPqkRJvgcY8zRqr1522oGXk false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:O95295 uniprotkb:Q19QW5 intact:EBI-296723|ensembl:ENSP00000357674|uniprotkb:Q5SXU8|uniprotkb:D3DV56 intact:EBI-25493595|uniprotkb:J9TC54 psi-mi:snapn_human(display_long)|uniprotkb:SNAPIN(gene name)|psi-mi:SNAPIN(display_short)|uniprotkb:SNAP25BP(gene name synonym)|uniprotkb:SNAPAP(gene name synonym)|uniprotkb:Synaptosomal-associated protein 25-binding protein(gene name synonym)|uniprotkb:BLOC1S7(gene name synonym)|uniprotkb:Biogenesis of lysosome-related organelles complex 1 subunit 7(gene name synonym) psi-mi:q19qw5_sars(display_long)|uniprotkb:ORF6(gene name)|psi-mi:ORF6(display_short)|uniprotkb:sars6(gene name synonym) psi-mi:"MI:0018"(two hybrid) Cheng et al. (2015) pubmed:25907116|imex:IM-28094 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-25649498|imex:IM-28094-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000143553(gene)|ensembl:ENST00000368685(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0002177"(manchette)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007040"(lysosome organization)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0030141"(secretory granule)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031083"(BLOC-1 complex)|go:"GO:0031175"(neuron projection development)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0032418"(lysosome localization)|go:"GO:0032438"(melanosome organization)|go:"GO:0034629"|go:"GO:0043393"(regulation of protein binding)|go:"GO:0045202"(synapse)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0048490"(anterograde synaptic vesicle transport)|go:"GO:0051604"(protein maturation)|go:"GO:0072553"(terminal button organization)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0099078"(BORC complex)|go:"GO:1902774"(late endosome to lysosome transport)|go:"GO:1902824"(positive regulation of late endosome to lysosome transport)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR017246(Snapin)|interpro:IPR028119|reactome:R-HSA-432722|refseq:NP_036569.1 go:"GO:0016020"(membrane)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044178"(host cell Golgi membrane)|interpro:IPR022736|refseq:NP_828856.1 - - - figure legend:Table 2|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/06/17 2020/06/17 rogid:V43p5MNgzla9VrcFKxPEIGWxYCM9606 rogid:FbI4KIsNxOBCtk9JMPiabQsxtXM694009 rigid:5nKw+3zNEGR9GYnoEL0O4mi7tlA false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q5XPI4 uniprotkb:Q19QW5 intact:EBI-1057418|uniprotkb:A6NLS5|uniprotkb:Q5I022|uniprotkb:Q6PFW4|uniprotkb:Q71RH0|uniprotkb:Q8IW18|uniprotkb:Q9H0M8|uniprotkb:Q9H5L8|uniprotkb:Q9H9T2|uniprotkb:A1L4Q3|ensembl:ENSP00000328287 intact:EBI-25493595|uniprotkb:J9TC54 psi-mi:rn123_human(display_long)|uniprotkb:RING-type E3 ubiquitin transferase RNF123(gene name synonym)|uniprotkb:FP1477(orf name)|uniprotkb:RNF123(gene name)|psi-mi:RNF123(display_short)|uniprotkb:KPC1(gene name synonym)|uniprotkb:RING finger protein 123(gene name synonym)|uniprotkb:Kip1 ubiquitination-promoting complex protein 1(gene name synonym) psi-mi:q19qw5_sars(display_long)|uniprotkb:ORF6(gene name)|psi-mi:ORF6(display_short)|uniprotkb:sars6(gene name synonym) psi-mi:"MI:0018"(two hybrid) Cheng et al. (2015) pubmed:25907116|imex:IM-28094 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-25649507|imex:IM-28094-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_071347.2|refseq:XP_011532297.1|refseq:XP_006713348.1|ensembl:ENSG00000164068(gene)|ensembl:ENST00000327697(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0031965"(nuclear membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR035773|interpro:IPR043136|rcsb pdb:2MA6|reactome:R-HSA-5689880|reactome:R-HSA-983168|refseq:XP_016862507.1 go:"GO:0016020"(membrane)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044178"(host cell Golgi membrane)|interpro:IPR022736|refseq:NP_828856.1 - - - figure legend:Table 2|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/06/17 2020/06/17 rogid:g+T7G1ZM4jNkUY+M0KP+MF3eeJU9606 rogid:FbI4KIsNxOBCtk9JMPiabQsxtXM694009 rigid:SYBaNVp73fr8JUSfWzF8nEg6N30 false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9UMX0 uniprotkb:Q19QW5 intact:EBI-741480|uniprotkb:Q8IXS9|uniprotkb:Q8N2Q3|uniprotkb:Q9H0T8|uniprotkb:Q9H3R4|uniprotkb:Q9HAZ5|intact:EBI-28967608|ensembl:ENSP00000365576|uniprotkb:Q5T6J5|uniprotkb:Q5T6J9|uniprotkb:A0A024R284 intact:EBI-25493595|uniprotkb:J9TC54 psi-mi:ubql1_human(display_long)|uniprotkb:Protein linking IAP with cytoskeleton 1(gene name synonym)|uniprotkb:UBQLN1(gene name)|psi-mi:UBQLN1(display_short)|uniprotkb:DA41(gene name synonym)|uniprotkb:PLIC1(gene name synonym) psi-mi:q19qw5_sars(display_long)|uniprotkb:ORF6(gene name)|psi-mi:ORF6(display_short)|uniprotkb:sars6(gene name synonym) psi-mi:"MI:0018"(two hybrid) Cheng et al. (2015) pubmed:25907116|imex:IM-28094 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-25649511|imex:IM-28094-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000257468|ensembl:ENSP00000257468|ensembl:ENSP00000365576|ensembl:ENSG00000135018(gene)|ensembl:ENST00000376395(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000502"(proteasome complex)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016235"(aggresome)|go:"GO:0016236"(macroautophagy)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0019900"(kinase binding)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035973"(aggrephagy)|go:"GO:0042802"(identical protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097352"(autophagosome maturation)|go:"GO:1901340"(negative regulation of store-operated calcium channel activity)|go:"GO:1902175"(regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903071"(positive regulation of ER-associated ubiquitin-dependent protein catabolic process)|interpro:IPR000626(Ubiquitin)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR009060(UBA-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR028430|interpro:IPR029071|mint:Q9UMX0|rcsb pdb:2JY5|rcsb pdb:2JY6|rcsb pdb:2KLC|reactome:R-HSA-8856825|refseq:NP_038466.2|refseq:NP_444295.1|dip:DIP-41629N go:"GO:0016020"(membrane)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044178"(host cell Golgi membrane)|interpro:IPR022736|refseq:NP_828856.1 - - - figure legend:Table 2|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/06/17 2020/06/17 rogid:nCFfZbGCTvRYaXhQ4R99XblslvM9606 rogid:FbI4KIsNxOBCtk9JMPiabQsxtXM694009 rigid:ad4cZbTrYAVYCSdEYYm8AIK4DNs false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P25685 uniprotkb:Q19QW5 intact:EBI-357034|ensembl:ENSP00000254322|uniprotkb:B4DX52 intact:EBI-25493595|uniprotkb:J9TC54 psi-mi:dnjb1_human(display_long)|uniprotkb:DNAJB1(gene name)|psi-mi:DNAJB1(display_short)|uniprotkb:DNAJ1(gene name synonym)|uniprotkb:HDJ1(gene name synonym)|uniprotkb:HSPF1(gene name synonym)|uniprotkb:Heat shock 40 kDa protein 1(gene name synonym)|uniprotkb:Human DnaJ protein 1(gene name synonym)|uniprotkb:DnaJ protein homolog 1(gene name synonym) psi-mi:q19qw5_sars(display_long)|uniprotkb:ORF6(gene name)|psi-mi:ORF6(display_short)|uniprotkb:sars6(gene name synonym) psi-mi:"MI:0018"(two hybrid) Cheng et al. (2015) pubmed:25907116|imex:IM-28094 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-25649515|imex:IM-28094-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-41180N|ensembl:ENSG00000132002(gene)|ensembl:ENST00000254322(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030900"(forebrain development)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|refseq:NP_006136.1|refseq:XP_006722796.1|refseq:NP_001287843.1|refseq:NP_001300893.1|refseq:XP_011526258.1|refseq:XP_006722797.1|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0061827"(sperm head)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090084"(negative regulation of inclusion body assembly)|go:"GO:0097201"(negative regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900034"(regulation of cellular response to heat)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR018253|interpro:IPR036869|mint:P25685|rcsb pdb:1HDJ|rcsb pdb:2QLD|rcsb pdb:3AGX|rcsb pdb:3AGY|rcsb pdb:3AGZ|rcsb pdb:4WB7|rcsb pdb:6BYR|rcsb pdb:6WJF|rcsb pdb:6WJG|rcsb pdb:6Z5N|reactome:R-HSA-3371453|reactome:R-HSA-3371497|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-5687128|interpro:IPR008971(HSP40/DnaJ peptide-binding) go:"GO:0016020"(membrane)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044178"(host cell Golgi membrane)|interpro:IPR022736|refseq:NP_828856.1 - - - figure legend:Table 2|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/06/17 2020/06/17 rogid:8NJHM7hHFc+zqulNiUM9UMxT/ws9606 rogid:FbI4KIsNxOBCtk9JMPiabQsxtXM694009 rigid:PjiFZrqWSBFADRab7m/PJN9LYtM false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P98161 uniprotkb:Q19QW5 intact:EBI-1752013|uniprotkb:Q15140|uniprotkb:Q15141|intact:EBI-28973367|ensembl:ENSP00000262304 intact:EBI-25493595|uniprotkb:J9TC54 psi-mi:pkd1_human(display_long)|uniprotkb:PKD1(gene name)|psi-mi:PKD1(display_short)|uniprotkb:Autosomal dominant polycystic kidney disease 1 protein(gene name synonym) psi-mi:q19qw5_sars(display_long)|uniprotkb:ORF6(gene name)|psi-mi:ORF6(display_short)|uniprotkb:sars6(gene name synonym) psi-mi:"MI:0018"(two hybrid) Cheng et al. (2015) pubmed:25907116|imex:IM-28094 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-25649519|imex:IM-28094-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000262304|ensembl:ENST00000423118|ensembl:ENSP00000399501|refseq:NP_000287.3|refseq:NP_001009944.2|dip:DIP-52317N|ensembl:ENSG00000008710(gene)|ensembl:ENST00000262304(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001822"(kidney development)|go:"GO:0001889"(liver development)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002133"(polycystin complex)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007161"(calcium-independent cell-matrix adhesion)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007507"(heart development)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021510"(spinal cord development)|go:"GO:0021915"(neural tube development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030660"(Golgi-associated vesicle membrane)|go:"GO:0031514"(motile cilium)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0034405"(response to fluid shear stress)|go:"GO:0034703"(cation channel complex)|go:"GO:0034704"(calcium channel complex)|go:"GO:0036303"(lymph vessel morphogenesis)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0043588"(skin development)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048565"(digestive tract development)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048806"(genitalia development)|go:"GO:0050982"(detection of mechanical stimulus)|go:"GO:0051216"(cartilage development)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0060428"(lung epithelium development)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0072164"(mesonephric tubule development)|go:"GO:0072177"(mesonephric duct development)|go:"GO:0072205"(metanephric collecting duct development)|go:"GO:0072218"(metanephric ascending thin limb development)|go:"GO:0072237"(metanephric proximal tubule development)|go:"GO:0072287"(metanephric distal tubule morphogenesis)|go:"GO:0198738"(cell-cell signaling by wnt)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000203(GPS)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR000434(Polycystic kidney disease type 1 protein)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR000601(PKD)|interpro:IPR001024(Lipoxygenase, LH2)|interpro:IPR001304(C-type lectin)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR002859(PKD/REJ-like protein)|interpro:IPR002889(Carbohydrate-binding WSC)|interpro:IPR006228(Polycystin cation channel)|interpro:IPR013122(Polycystin cation channel, PKD1/PKD2)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014010(Egg jelly receptor, REJ-like)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR022409|interpro:IPR032675|interpro:IPR035986|interpro:IPR036392|interpro:IPR042060|mint:P98161|rcsb pdb:1B4R|rcsb pdb:6A70|reactome:R-HSA-5620916|interpro:IPR003591(Leucine-rich repeat, typical subtype) go:"GO:0016020"(membrane)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044178"(host cell Golgi membrane)|interpro:IPR022736|refseq:NP_828856.1 - - - figure legend:Table 2|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/06/17 2020/06/17 rogid:5sjZUQZacorsQPt5nSELPNsvfX09606 rogid:FbI4KIsNxOBCtk9JMPiabQsxtXM694009 rigid:v1DvyZ/myHBtuzS4lbSI6vFLlfw false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q13009 uniprotkb:Q19QW5 intact:EBI-1050007|uniprotkb:Q17RT7|ensembl:ENSP00000286827|uniprotkb:B7ZLR6|uniprotkb:F5GZ53 intact:EBI-25493595|uniprotkb:J9TC54 psi-mi:tiam1_human(display_long)|uniprotkb:TIAM1(gene name)|psi-mi:TIAM1(display_short)|uniprotkb:T-lymphoma invasion and metastasis-inducing protein 1(gene name synonym) psi-mi:q19qw5_sars(display_long)|uniprotkb:ORF6(gene name)|psi-mi:ORF6(display_short)|uniprotkb:sars6(gene name synonym) psi-mi:"MI:0018"(two hybrid) Cheng et al. (2015) pubmed:25907116|imex:IM-28094 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-25649523|imex:IM-28094-13 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003244.2|refseq:XP_016883936.1|refseq:XP_016883937.1|refseq:XP_016883938.1|refseq:XP_016883939.1|refseq:XP_016883940.1|refseq:XP_016883941.1|refseq:XP_016883942.1|ensembl:ENSG00000156299(gene)|ensembl:ENST00000286827(transcript)|go:"GO:0003300"(cardiac muscle hypertrophy)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006915"(apoptotic process)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008017"(microtubule binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0019900"(kinase binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0034622"|go:"GO:0042220"(response to cocaine)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0008289"(lipid binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044304"(main axon)|go:"GO:0045202"(synapse)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098989"(NMDA selective glutamate receptor signaling pathway)|go:"GO:0099147"(extrinsic component of postsynaptic density membrane)|go:"GO:1904268"(positive regulation of Schwann cell chemotaxis)|go:"GO:1904338"(regulation of dopaminergic neuron differentiation)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:1990138"(neuron projection extension)|go:"GO:2000050"(regulation of non-canonical Wnt signaling pathway)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR033360|interpro:IPR035899|interpro:IPR036034|interpro:IPR040655|interpro:IPR043537|mint:Q13009|rcsb pdb:2D8I|rcsb pdb:3KZD|rcsb pdb:3KZE|rcsb pdb:4GVC|rcsb pdb:4GVD|rcsb pdb:4K2O|rcsb pdb:4K2P|rcsb pdb:4NXP|rcsb pdb:4NXQ|rcsb pdb:4NXR|reactome:R-HSA-193648|reactome:R-HSA-3928662|reactome:R-HSA-3928665|reactome:R-HSA-416482|reactome:R-HSA-8980692|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9032845|refseq:XP_005261094.1|refseq:XP_005261095.1|refseq:XP_011528013.1|refseq:XP_011528014.1|refseq:XP_011528015.1|dip:DIP-38309N go:"GO:0016020"(membrane)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044178"(host cell Golgi membrane)|interpro:IPR022736|refseq:NP_828856.1 - - - dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/06/17 2020/06/17 rogid:h0ruHb93yvgrex2b+d2JNrph60A9606 rogid:FbI4KIsNxOBCtk9JMPiabQsxtXM694009 rigid:rM6PKvx78qonT3LqHhFAR1+OaWg false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q5TBA9 uniprotkb:Q19QW5 intact:EBI-2816917|uniprotkb:Q9Y3N6|intact:EBI-28984104|ensembl:ENSP00000445043 intact:EBI-25493595|uniprotkb:J9TC54 psi-mi:fry_human(display_long)|uniprotkb:FRY(gene name)|psi-mi:FRY(display_short)|uniprotkb:C13orf14(gene name synonym) psi-mi:q19qw5_sars(display_long)|uniprotkb:ORF6(gene name)|psi-mi:ORF6(display_short)|uniprotkb:sars6(gene name synonym) psi-mi:"MI:0018"(two hybrid) Cheng et al. (2015) pubmed:25907116|imex:IM-28094 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-25649532|imex:IM-28094-15 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_075463.2|ensembl:ENSP00000445043|ensembl:ENSG00000073910(gene)|ensembl:ENST00000542859(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000922"(spindle pole)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005938"(cell cortex)|go:"GO:0030427"(site of polarized growth)|go:"GO:0031175"(neuron projection development)|go:"GO:1904428"(negative regulation of tubulin deacetylation)|interpro:IPR025481|interpro:IPR025614|interpro:IPR029473|interpro:IPR039867|mint:Q5TBA9 go:"GO:0016020"(membrane)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044178"(host cell Golgi membrane)|interpro:IPR022736|refseq:NP_828856.1 - - - figure legend:Table 2|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/06/17 2020/06/17 rogid:XSGKUpD+VVyYJ1ew69qbPQnoJWg9606 rogid:FbI4KIsNxOBCtk9JMPiabQsxtXM694009 rigid:UYJ59uwmB1Fo/67kV/kDI/rUELs false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q19QW5 uniprotkb:Q13287 intact:EBI-25493595|uniprotkb:J9TC54 intact:EBI-372942|uniprotkb:Q53TI8|intact:EBI-10174268|uniprotkb:Q8WTW2|uniprotkb:Q9BVE5|uniprotkb:B5BU69|ensembl:ENSP00000243346 psi-mi:q19qw5_sars(display_long)|uniprotkb:ORF6(gene name)|psi-mi:ORF6(display_short)|uniprotkb:sars6(gene name synonym) psi-mi:nmi_human(display_long)|uniprotkb:NMI(gene name)|psi-mi:NMI(display_short)|uniprotkb:N-myc and STAT interactor(gene name synonym) psi-mi:"MI:0018"(two hybrid) Cheng et al. (2015) pubmed:25907116|imex:IM-28094 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-25649547|imex:IM-28094-17 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016020"(membrane)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044178"(host cell Golgi membrane)|interpro:IPR022736|refseq:NP_828856.1 refseq:NP_004679.2|refseq:XP_005246998.1|ensembl:ENSG00000123609(gene)|ensembl:ENST00000243346(transcript)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009615"(response to virus)|go:"GO:0016020"(membrane)|go:"GO:0032687"(negative regulation of interferon-alpha production)|go:"GO:0032688"(negative regulation of interferon-beta production)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045824"(negative regulation of innate immune response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902524"(positive regulation of protein K48-linked ubiquitination)|interpro:IPR009909(Nmi/IFP 35)|interpro:IPR009938(Interferon-induced 35 kDa, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033527|mint:Q13287|refseq:XP_016860736.1 - - - figure legend:Fig. 1|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/06/17 2020/06/17 rogid:FbI4KIsNxOBCtk9JMPiabQsxtXM694009 rogid:qOkzIuloaWW88apb9JH2DT/Bnuk9606 rigid:6uQXnPqkRJvgcY8zRqr1522oGXk false necessary binding region:40-63|sufficient binding region:40-63 sufficient binding region:1-260 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q19QW5 uniprotkb:Q13287 intact:EBI-25493595|uniprotkb:J9TC54 intact:EBI-372942|uniprotkb:Q53TI8|intact:EBI-10174268|uniprotkb:Q8WTW2|uniprotkb:Q9BVE5|uniprotkb:B5BU69|ensembl:ENSP00000243346 psi-mi:q19qw5_sars(display_long)|uniprotkb:ORF6(gene name)|psi-mi:ORF6(display_short)|uniprotkb:sars6(gene name synonym) psi-mi:nmi_human(display_long)|uniprotkb:NMI(gene name)|psi-mi:NMI(display_short)|uniprotkb:N-myc and STAT interactor(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Cheng et al. (2015) pubmed:25907116|imex:IM-28094 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-25649570|imex:IM-28094-19 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016020"(membrane)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044178"(host cell Golgi membrane)|interpro:IPR022736|refseq:NP_828856.1 refseq:NP_004679.2|refseq:XP_005246998.1|ensembl:ENSG00000123609(gene)|ensembl:ENST00000243346(transcript)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009615"(response to virus)|go:"GO:0016020"(membrane)|go:"GO:0032687"(negative regulation of interferon-alpha production)|go:"GO:0032688"(negative regulation of interferon-beta production)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045824"(negative regulation of innate immune response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902524"(positive regulation of protein K48-linked ubiquitination)|interpro:IPR009909(Nmi/IFP 35)|interpro:IPR009938(Interferon-induced 35 kDa, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033527|mint:Q13287|refseq:XP_016860736.1 - - - figure legend:Fig. 2|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2020/06/17 2020/06/17 rogid:FbI4KIsNxOBCtk9JMPiabQsxtXM694009 rogid:qOkzIuloaWW88apb9JH2DT/Bnuk9606 rigid:6uQXnPqkRJvgcY8zRqr1522oGXk false ha tag:?-? green fluorescent protein tag:?-? - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0422"(immunostaining)