#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9H334	uniprotkb:Q9H334	intact:EBI-983809|uniprotkb:Q9H332|uniprotkb:Q9H333|uniprotkb:Q9P0R1|intact:EBI-28984754|ensembl:ENSP00000318902|ensembl:ENSP00000418102|ensembl:ENSP00000419393|ensembl:ENSP00000496990|ensembl:ENSP00000497344|ensembl:ENSP00000497369|uniprotkb:A3QVP8|uniprotkb:Q9BSG9|uniprotkb:B3KV70|uniprotkb:G5E9V8|uniprotkb:Q8NAN6	intact:EBI-983809|uniprotkb:Q9H332|uniprotkb:Q9H333|uniprotkb:Q9P0R1|intact:EBI-28984754|ensembl:ENSP00000318902|ensembl:ENSP00000418102|ensembl:ENSP00000419393|ensembl:ENSP00000496990|ensembl:ENSP00000497344|ensembl:ENSP00000497369|uniprotkb:A3QVP8|uniprotkb:Q9BSG9|uniprotkb:B3KV70|uniprotkb:G5E9V8|uniprotkb:Q8NAN6	psi-mi:foxp1_human(display_long)|uniprotkb:FOXP1(gene name)|psi-mi:FOXP1(display_short)|uniprotkb:Mac-1-regulated forkhead(gene name synonym)|uniprotkb:HSPC215(orf name)	psi-mi:foxp1_human(display_long)|uniprotkb:FOXP1(gene name)|psi-mi:FOXP1(display_short)|uniprotkb:Mac-1-regulated forkhead(gene name synonym)|uniprotkb:HSPC215(orf name)	psi-mi:"MI:0012"(bioluminescence resonance energy transfer)	Lozano et al. (2015)	imex:IM-28574|pubmed:25853299	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26564909|imex:IM-28574-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006713165.1|refseq:XP_006713166.1|refseq:XP_006713167.1|go:"GO:0032655"(regulation of interleukin-12 production)|go:"GO:0032680"(regulation of tumor necrosis factor production)|go:"GO:0032651"(regulation of interleukin-1 beta production)|go:"GO:0032745"(positive regulation of interleukin-21 production)|go:"GO:0036035"(osteoclast development)|go:"GO:0042116"(macrophage activation)|go:"GO:0042117"(monocyte activation)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045655"(regulation of monocyte differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0050727"(regulation of inflammatory response)|ensembl:ENSG00000114861(gene)|ensembl:ENST00000318789(transcript)|ensembl:ENST00000475937(transcript)|ensembl:ENST00000498215(transcript)|ensembl:ENST00000648380(transcript)|ensembl:ENST00000649528(transcript)|ensembl:ENST00000649631(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002903"(negative regulation of B cell apoptotic process)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|rcsb pdb:2KIU|reactome:R-HSA-452723|mint:Q9H334|go:"GO:0050861"(positive regulation of B cell receptor signaling pathway)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0061470"(T follicular helper cell differentiation)|go:"GO:1900424"(regulation of defense response to bacterium)|go:"GO:1901256"(regulation of macrophage colony-stimulating factor production)|go:"GO:1901509"(regulation of endothelial tube morphogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000341"("regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR001766(Fork head transcription factor)|interpro:IPR030456|interpro:IPR032354|interpro:IPR036388|interpro:IPR036390|refseq:XP_011531886.1|refseq:XP_011531887.1|refseq:NP_116071.2|refseq:NP_001231743.1|refseq:NP_001231745.1|refseq:NP_001231744.1|refseq:NP_001012523.1|ensembl:ENST00000318779|ensembl:ENSP00000318721|ensembl:ENSP00000318902|ensembl:ENSP00000419393|ensembl:ENST00000484350|ensembl:ENSP00000417857|ensembl:ENST00000493089|ensembl:ENSP00000418524|ensembl:ENSP00000418102|ensembl:ENST00000615603|ensembl:ENSP00000484803|ensembl:ENST00000622151|ensembl:ENSP00000477918|ensembl:ENST00000648107|ensembl:ENSP00000497914|ensembl:ENSP00000497344|ensembl:ENST00000648426|ensembl:ENSP00000498110|ensembl:ENST00000648662|ensembl:ENSP00000496873|ensembl:ENST00000648718|ensembl:ENSP00000496810|ensembl:ENSP00000497369|ensembl:ENSP00000496990|ensembl:ENST00000674446|ensembl:ENSP00000501439|dip:DIP-36585N|refseq:XP_016861654.1|refseq:XP_016861655.1|refseq:XP_016861657.1|refseq:NP_001231741.1|refseq:NP_001231737.1|refseq:NP_001231739.1	refseq:XP_006713165.1|refseq:XP_006713166.1|refseq:XP_006713167.1|go:"GO:0032655"(regulation of interleukin-12 production)|go:"GO:0032680"(regulation of tumor necrosis factor production)|go:"GO:0032651"(regulation of interleukin-1 beta production)|go:"GO:0032745"(positive regulation of interleukin-21 production)|go:"GO:0036035"(osteoclast development)|go:"GO:0042116"(macrophage activation)|go:"GO:0042117"(monocyte activation)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045655"(regulation of monocyte differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0050727"(regulation of inflammatory response)|ensembl:ENSG00000114861(gene)|ensembl:ENST00000318789(transcript)|ensembl:ENST00000475937(transcript)|ensembl:ENST00000498215(transcript)|ensembl:ENST00000648380(transcript)|ensembl:ENST00000649528(transcript)|ensembl:ENST00000649631(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002903"(negative regulation of B cell apoptotic process)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|rcsb pdb:2KIU|reactome:R-HSA-452723|mint:Q9H334|go:"GO:0050861"(positive regulation of B cell receptor signaling pathway)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0061470"(T follicular helper cell differentiation)|go:"GO:1900424"(regulation of defense response to bacterium)|go:"GO:1901256"(regulation of macrophage colony-stimulating factor production)|go:"GO:1901509"(regulation of endothelial tube morphogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000341"("regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR001766(Fork head transcription factor)|interpro:IPR030456|interpro:IPR032354|interpro:IPR036388|interpro:IPR036390|refseq:XP_011531886.1|refseq:XP_011531887.1|refseq:NP_116071.2|refseq:NP_001231743.1|refseq:NP_001231745.1|refseq:NP_001231744.1|refseq:NP_001012523.1|ensembl:ENST00000318779|ensembl:ENSP00000318721|ensembl:ENSP00000318902|ensembl:ENSP00000419393|ensembl:ENST00000484350|ensembl:ENSP00000417857|ensembl:ENST00000493089|ensembl:ENSP00000418524|ensembl:ENSP00000418102|ensembl:ENST00000615603|ensembl:ENSP00000484803|ensembl:ENST00000622151|ensembl:ENSP00000477918|ensembl:ENST00000648107|ensembl:ENSP00000497914|ensembl:ENSP00000497344|ensembl:ENST00000648426|ensembl:ENSP00000498110|ensembl:ENST00000648662|ensembl:ENSP00000496873|ensembl:ENST00000648718|ensembl:ENSP00000496810|ensembl:ENSP00000497369|ensembl:ENSP00000496990|ensembl:ENST00000674446|ensembl:ENSP00000501439|dip:DIP-36585N|refseq:XP_016861654.1|refseq:XP_016861655.1|refseq:XP_016861657.1|refseq:NP_001231741.1|refseq:NP_001231737.1|refseq:NP_001231739.1	-	-	-	figure legend:fig. 2D|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2020/12/15	2020/12/15	rogid:NREo12e1TLPfsul6Ie0l62NqIa89606	rogid:NREo12e1TLPfsul6Ie0l62NqIa89606	rigid:tnb3LF63UiToOd8jT6SYJnrvEQY	false	yellow fluorescent protein tag:?-?|mutation with no effect:423-677(rs786200948)	luciferase tag:?-?	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:Q9H334	uniprotkb:O15409	intact:EBI-983809|uniprotkb:Q9H332|uniprotkb:Q9H333|uniprotkb:Q9P0R1|intact:EBI-28984754|ensembl:ENSP00000318902|ensembl:ENSP00000418102|ensembl:ENSP00000419393|ensembl:ENSP00000496990|ensembl:ENSP00000497344|ensembl:ENSP00000497369|uniprotkb:A3QVP8|uniprotkb:Q9BSG9|uniprotkb:B3KV70|uniprotkb:G5E9V8|uniprotkb:Q8NAN6	intact:EBI-983612|uniprotkb:A0AUV6|uniprotkb:A4D0U8|uniprotkb:Q6ZND1|uniprotkb:Q75MJ3|uniprotkb:Q8IZE0|uniprotkb:Q8N0W2|uniprotkb:Q8N6B7|uniprotkb:Q8N6B8|uniprotkb:Q8NFQ1|uniprotkb:Q8NFQ2|uniprotkb:Q8NFQ3|uniprotkb:Q8NFQ4|uniprotkb:Q8TD74|ensembl:ENSP00000265436|ensembl:ENSP00000377132|uniprotkb:A6NNW4|uniprotkb:B4DLD9	psi-mi:foxp1_human(display_long)|uniprotkb:FOXP1(gene name)|psi-mi:FOXP1(display_short)|uniprotkb:Mac-1-regulated forkhead(gene name synonym)|uniprotkb:HSPC215(orf name)	psi-mi:foxp2_human(display_long)|uniprotkb:CAG repeat protein 44(gene name synonym)|uniprotkb:Trinucleotide repeat-containing gene 10 protein(gene name synonym)|uniprotkb:FOXP2(gene name)|psi-mi:FOXP2(display_short)|uniprotkb:CAGH44(gene name synonym)|uniprotkb:TNRC10(gene name synonym)	psi-mi:"MI:0012"(bioluminescence resonance energy transfer)	Lozano et al. (2015)	imex:IM-28574|pubmed:25853299	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26565047|imex:IM-28574-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006713165.1|refseq:XP_006713166.1|refseq:XP_006713167.1|go:"GO:0032655"(regulation of interleukin-12 production)|go:"GO:0032680"(regulation of tumor necrosis factor production)|go:"GO:0032651"(regulation of interleukin-1 beta production)|go:"GO:0032745"(positive regulation of interleukin-21 production)|go:"GO:0036035"(osteoclast development)|go:"GO:0042116"(macrophage activation)|go:"GO:0042117"(monocyte activation)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045655"(regulation of monocyte differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0050727"(regulation of inflammatory response)|ensembl:ENSG00000114861(gene)|ensembl:ENST00000318789(transcript)|ensembl:ENST00000475937(transcript)|ensembl:ENST00000498215(transcript)|ensembl:ENST00000648380(transcript)|ensembl:ENST00000649528(transcript)|ensembl:ENST00000649631(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002903"(negative regulation of B cell apoptotic process)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|rcsb pdb:2KIU|reactome:R-HSA-452723|mint:Q9H334|go:"GO:0050861"(positive regulation of B cell receptor signaling pathway)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0061470"(T follicular helper cell differentiation)|go:"GO:1900424"(regulation of defense response to bacterium)|go:"GO:1901256"(regulation of macrophage colony-stimulating factor production)|go:"GO:1901509"(regulation of endothelial tube morphogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000341"("regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR001766(Fork head transcription factor)|interpro:IPR030456|interpro:IPR032354|interpro:IPR036388|interpro:IPR036390|refseq:XP_011531886.1|refseq:XP_011531887.1|refseq:NP_116071.2|refseq:NP_001231743.1|refseq:NP_001231745.1|refseq:NP_001231744.1|refseq:NP_001012523.1|ensembl:ENST00000318779|ensembl:ENSP00000318721|ensembl:ENSP00000318902|ensembl:ENSP00000419393|ensembl:ENST00000484350|ensembl:ENSP00000417857|ensembl:ENST00000493089|ensembl:ENSP00000418524|ensembl:ENSP00000418102|ensembl:ENST00000615603|ensembl:ENSP00000484803|ensembl:ENST00000622151|ensembl:ENSP00000477918|ensembl:ENST00000648107|ensembl:ENSP00000497914|ensembl:ENSP00000497344|ensembl:ENST00000648426|ensembl:ENSP00000498110|ensembl:ENST00000648662|ensembl:ENSP00000496873|ensembl:ENST00000648718|ensembl:ENSP00000496810|ensembl:ENSP00000497369|ensembl:ENSP00000496990|ensembl:ENST00000674446|ensembl:ENSP00000501439|dip:DIP-36585N|refseq:XP_016861654.1|refseq:XP_016861655.1|refseq:XP_016861657.1|refseq:NP_001231741.1|refseq:NP_001231737.1|refseq:NP_001231739.1	ensembl:ENSG00000128573(gene)|ensembl:ENST00000350908(transcript)|ensembl:ENST00000393494(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0021757"(caudate nucleus development)|go:"GO:0021758"(putamen development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0033574"(response to testosterone)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0098582"(innate vocalization behavior)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR030456|interpro:IPR032354|interpro:IPR036388|interpro:IPR036390|mint:O15409|rcsb pdb:2A07|rcsb pdb:2AS5|go:"GO:0046872"(metal ion binding)|refseq:NP_001166237.1|refseq:NP_001166238.1|refseq:NP_055306.1|refseq:NP_683696.2|refseq:NP_683697.2|refseq:NP_683698.2|dip:DIP-29004N|refseq:XP_016868290.1	-	-	-	figure legend:fig. 2D|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2020/12/15	2020/12/15	rogid:NREo12e1TLPfsul6Ie0l62NqIa89606	rogid:XRN9auLs2qtK6W3mjHJHAQPbO9s9606	rigid:zXjmRyOSMZge1sszh6NclUm6d5M	false	yellow fluorescent protein tag:?-?|mutation with no effect:423-677(rs786200948)	luciferase tag:?-?	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:Q9H334	uniprotkb:O15409	intact:EBI-983809|uniprotkb:Q9H332|uniprotkb:Q9H333|uniprotkb:Q9P0R1|intact:EBI-28984754|ensembl:ENSP00000318902|ensembl:ENSP00000418102|ensembl:ENSP00000419393|ensembl:ENSP00000496990|ensembl:ENSP00000497344|ensembl:ENSP00000497369|uniprotkb:A3QVP8|uniprotkb:Q9BSG9|uniprotkb:B3KV70|uniprotkb:G5E9V8|uniprotkb:Q8NAN6	intact:EBI-983612|uniprotkb:A0AUV6|uniprotkb:A4D0U8|uniprotkb:Q6ZND1|uniprotkb:Q75MJ3|uniprotkb:Q8IZE0|uniprotkb:Q8N0W2|uniprotkb:Q8N6B7|uniprotkb:Q8N6B8|uniprotkb:Q8NFQ1|uniprotkb:Q8NFQ2|uniprotkb:Q8NFQ3|uniprotkb:Q8NFQ4|uniprotkb:Q8TD74|ensembl:ENSP00000265436|ensembl:ENSP00000377132|uniprotkb:A6NNW4|uniprotkb:B4DLD9	psi-mi:foxp1_human(display_long)|uniprotkb:FOXP1(gene name)|psi-mi:FOXP1(display_short)|uniprotkb:Mac-1-regulated forkhead(gene name synonym)|uniprotkb:HSPC215(orf name)	psi-mi:foxp2_human(display_long)|uniprotkb:CAG repeat protein 44(gene name synonym)|uniprotkb:Trinucleotide repeat-containing gene 10 protein(gene name synonym)|uniprotkb:FOXP2(gene name)|psi-mi:FOXP2(display_short)|uniprotkb:CAGH44(gene name synonym)|uniprotkb:TNRC10(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Lozano et al. (2015)	imex:IM-28574|pubmed:25853299	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-26565086|imex:IM-28574-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006713165.1|refseq:XP_006713166.1|refseq:XP_006713167.1|go:"GO:0032655"(regulation of interleukin-12 production)|go:"GO:0032680"(regulation of tumor necrosis factor production)|go:"GO:0032651"(regulation of interleukin-1 beta production)|go:"GO:0032745"(positive regulation of interleukin-21 production)|go:"GO:0036035"(osteoclast development)|go:"GO:0042116"(macrophage activation)|go:"GO:0042117"(monocyte activation)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045655"(regulation of monocyte differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0050727"(regulation of inflammatory response)|ensembl:ENSG00000114861(gene)|ensembl:ENST00000318789(transcript)|ensembl:ENST00000475937(transcript)|ensembl:ENST00000498215(transcript)|ensembl:ENST00000648380(transcript)|ensembl:ENST00000649528(transcript)|ensembl:ENST00000649631(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002903"(negative regulation of B cell apoptotic process)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|rcsb pdb:2KIU|reactome:R-HSA-452723|mint:Q9H334|go:"GO:0050861"(positive regulation of B cell receptor signaling pathway)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0061470"(T follicular helper cell differentiation)|go:"GO:1900424"(regulation of defense response to bacterium)|go:"GO:1901256"(regulation of macrophage colony-stimulating factor production)|go:"GO:1901509"(regulation of endothelial tube morphogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000341"("regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR001766(Fork head transcription factor)|interpro:IPR030456|interpro:IPR032354|interpro:IPR036388|interpro:IPR036390|refseq:XP_011531886.1|refseq:XP_011531887.1|refseq:NP_116071.2|refseq:NP_001231743.1|refseq:NP_001231745.1|refseq:NP_001231744.1|refseq:NP_001012523.1|ensembl:ENST00000318779|ensembl:ENSP00000318721|ensembl:ENSP00000318902|ensembl:ENSP00000419393|ensembl:ENST00000484350|ensembl:ENSP00000417857|ensembl:ENST00000493089|ensembl:ENSP00000418524|ensembl:ENSP00000418102|ensembl:ENST00000615603|ensembl:ENSP00000484803|ensembl:ENST00000622151|ensembl:ENSP00000477918|ensembl:ENST00000648107|ensembl:ENSP00000497914|ensembl:ENSP00000497344|ensembl:ENST00000648426|ensembl:ENSP00000498110|ensembl:ENST00000648662|ensembl:ENSP00000496873|ensembl:ENST00000648718|ensembl:ENSP00000496810|ensembl:ENSP00000497369|ensembl:ENSP00000496990|ensembl:ENST00000674446|ensembl:ENSP00000501439|dip:DIP-36585N|refseq:XP_016861654.1|refseq:XP_016861655.1|refseq:XP_016861657.1|refseq:NP_001231741.1|refseq:NP_001231737.1|refseq:NP_001231739.1	ensembl:ENSG00000128573(gene)|ensembl:ENST00000350908(transcript)|ensembl:ENST00000393494(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0021757"(caudate nucleus development)|go:"GO:0021758"(putamen development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0033574"(response to testosterone)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0098582"(innate vocalization behavior)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR030456|interpro:IPR032354|interpro:IPR036388|interpro:IPR036390|mint:O15409|rcsb pdb:2A07|rcsb pdb:2AS5|go:"GO:0046872"(metal ion binding)|refseq:NP_001166237.1|refseq:NP_001166238.1|refseq:NP_055306.1|refseq:NP_683696.2|refseq:NP_683697.2|refseq:NP_683698.2|dip:DIP-29004N|refseq:XP_016868290.1	go:"GO:0005634"(nucleus)	-	-	figure legend:fig. S3C|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-sh_sy5y)|taxid:9606(Homo sapiens SH-SY5Y cell line)	-	2020/12/15	2020/12/15	rogid:NREo12e1TLPfsul6Ie0l62NqIa89606	rogid:XRN9auLs2qtK6W3mjHJHAQPbO9s9606	rigid:zXjmRyOSMZge1sszh6NclUm6d5M	false	mcherry fluorescent protein tag:?-?|mutation disrupting interaction strength:423-677(rs786200948)	yellow fluorescent protein tag:?-?	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:Q9H334	uniprotkb:Q9H334	intact:EBI-983809|uniprotkb:Q9H332|uniprotkb:Q9H333|uniprotkb:Q9P0R1|intact:EBI-28984754|ensembl:ENSP00000318902|ensembl:ENSP00000418102|ensembl:ENSP00000419393|ensembl:ENSP00000496990|ensembl:ENSP00000497344|ensembl:ENSP00000497369|uniprotkb:A3QVP8|uniprotkb:Q9BSG9|uniprotkb:B3KV70|uniprotkb:G5E9V8|uniprotkb:Q8NAN6	intact:EBI-983809|uniprotkb:Q9H332|uniprotkb:Q9H333|uniprotkb:Q9P0R1|intact:EBI-28984754|ensembl:ENSP00000318902|ensembl:ENSP00000418102|ensembl:ENSP00000419393|ensembl:ENSP00000496990|ensembl:ENSP00000497344|ensembl:ENSP00000497369|uniprotkb:A3QVP8|uniprotkb:Q9BSG9|uniprotkb:B3KV70|uniprotkb:G5E9V8|uniprotkb:Q8NAN6	psi-mi:foxp1_human(display_long)|uniprotkb:FOXP1(gene name)|psi-mi:FOXP1(display_short)|uniprotkb:Mac-1-regulated forkhead(gene name synonym)|uniprotkb:HSPC215(orf name)	psi-mi:foxp1_human(display_long)|uniprotkb:FOXP1(gene name)|psi-mi:FOXP1(display_short)|uniprotkb:Mac-1-regulated forkhead(gene name synonym)|uniprotkb:HSPC215(orf name)	psi-mi:"MI:0416"(fluorescence microscopy)	Lozano et al. (2015)	imex:IM-28574|pubmed:25853299	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-26565063|imex:IM-28574-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006713165.1|refseq:XP_006713166.1|refseq:XP_006713167.1|go:"GO:0032655"(regulation of interleukin-12 production)|go:"GO:0032680"(regulation of tumor necrosis factor production)|go:"GO:0032651"(regulation of interleukin-1 beta production)|go:"GO:0032745"(positive regulation of interleukin-21 production)|go:"GO:0036035"(osteoclast development)|go:"GO:0042116"(macrophage activation)|go:"GO:0042117"(monocyte activation)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045655"(regulation of monocyte differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0050727"(regulation of inflammatory response)|ensembl:ENSG00000114861(gene)|ensembl:ENST00000318789(transcript)|ensembl:ENST00000475937(transcript)|ensembl:ENST00000498215(transcript)|ensembl:ENST00000648380(transcript)|ensembl:ENST00000649528(transcript)|ensembl:ENST00000649631(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002903"(negative regulation of B cell apoptotic process)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|rcsb pdb:2KIU|reactome:R-HSA-452723|mint:Q9H334|go:"GO:0050861"(positive regulation of B cell receptor signaling pathway)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0061470"(T follicular helper cell differentiation)|go:"GO:1900424"(regulation of defense response to bacterium)|go:"GO:1901256"(regulation of macrophage colony-stimulating factor production)|go:"GO:1901509"(regulation of endothelial tube morphogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000341"("regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR001766(Fork head transcription factor)|interpro:IPR030456|interpro:IPR032354|interpro:IPR036388|interpro:IPR036390|refseq:XP_011531886.1|refseq:XP_011531887.1|refseq:NP_116071.2|refseq:NP_001231743.1|refseq:NP_001231745.1|refseq:NP_001231744.1|refseq:NP_001012523.1|ensembl:ENST00000318779|ensembl:ENSP00000318721|ensembl:ENSP00000318902|ensembl:ENSP00000419393|ensembl:ENST00000484350|ensembl:ENSP00000417857|ensembl:ENST00000493089|ensembl:ENSP00000418524|ensembl:ENSP00000418102|ensembl:ENST00000615603|ensembl:ENSP00000484803|ensembl:ENST00000622151|ensembl:ENSP00000477918|ensembl:ENST00000648107|ensembl:ENSP00000497914|ensembl:ENSP00000497344|ensembl:ENST00000648426|ensembl:ENSP00000498110|ensembl:ENST00000648662|ensembl:ENSP00000496873|ensembl:ENST00000648718|ensembl:ENSP00000496810|ensembl:ENSP00000497369|ensembl:ENSP00000496990|ensembl:ENST00000674446|ensembl:ENSP00000501439|dip:DIP-36585N|refseq:XP_016861654.1|refseq:XP_016861655.1|refseq:XP_016861657.1|refseq:NP_001231741.1|refseq:NP_001231737.1|refseq:NP_001231739.1	refseq:XP_006713165.1|refseq:XP_006713166.1|refseq:XP_006713167.1|go:"GO:0032655"(regulation of interleukin-12 production)|go:"GO:0032680"(regulation of tumor necrosis factor production)|go:"GO:0032651"(regulation of interleukin-1 beta production)|go:"GO:0032745"(positive regulation of interleukin-21 production)|go:"GO:0036035"(osteoclast development)|go:"GO:0042116"(macrophage activation)|go:"GO:0042117"(monocyte activation)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045655"(regulation of monocyte differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0050727"(regulation of inflammatory response)|ensembl:ENSG00000114861(gene)|ensembl:ENST00000318789(transcript)|ensembl:ENST00000475937(transcript)|ensembl:ENST00000498215(transcript)|ensembl:ENST00000648380(transcript)|ensembl:ENST00000649528(transcript)|ensembl:ENST00000649631(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002903"(negative regulation of B cell apoptotic process)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|rcsb pdb:2KIU|reactome:R-HSA-452723|mint:Q9H334|go:"GO:0050861"(positive regulation of B cell receptor signaling pathway)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0061470"(T follicular helper cell differentiation)|go:"GO:1900424"(regulation of defense response to bacterium)|go:"GO:1901256"(regulation of macrophage colony-stimulating factor production)|go:"GO:1901509"(regulation of endothelial tube morphogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000341"("regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR001766(Fork head transcription factor)|interpro:IPR030456|interpro:IPR032354|interpro:IPR036388|interpro:IPR036390|refseq:XP_011531886.1|refseq:XP_011531887.1|refseq:NP_116071.2|refseq:NP_001231743.1|refseq:NP_001231745.1|refseq:NP_001231744.1|refseq:NP_001012523.1|ensembl:ENST00000318779|ensembl:ENSP00000318721|ensembl:ENSP00000318902|ensembl:ENSP00000419393|ensembl:ENST00000484350|ensembl:ENSP00000417857|ensembl:ENST00000493089|ensembl:ENSP00000418524|ensembl:ENSP00000418102|ensembl:ENST00000615603|ensembl:ENSP00000484803|ensembl:ENST00000622151|ensembl:ENSP00000477918|ensembl:ENST00000648107|ensembl:ENSP00000497914|ensembl:ENSP00000497344|ensembl:ENST00000648426|ensembl:ENSP00000498110|ensembl:ENST00000648662|ensembl:ENSP00000496873|ensembl:ENST00000648718|ensembl:ENSP00000496810|ensembl:ENSP00000497369|ensembl:ENSP00000496990|ensembl:ENST00000674446|ensembl:ENSP00000501439|dip:DIP-36585N|refseq:XP_016861654.1|refseq:XP_016861655.1|refseq:XP_016861657.1|refseq:NP_001231741.1|refseq:NP_001231737.1|refseq:NP_001231739.1	go:"GO:0005634"(nucleus)	-	-	figure legend:fig. S3C|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2020/12/15	2020/12/15	rogid:NREo12e1TLPfsul6Ie0l62NqIa89606	rogid:NREo12e1TLPfsul6Ie0l62NqIa89606	rigid:tnb3LF63UiToOd8jT6SYJnrvEQY	false	mcherry fluorescent protein tag:?-?|mutation with complex effect:423-677(rs786200948)	yellow fluorescent protein tag:?-?	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:Q9H334	uniprotkb:Q9H334	intact:EBI-983809|uniprotkb:Q9H332|uniprotkb:Q9H333|uniprotkb:Q9P0R1|intact:EBI-28984754|ensembl:ENSP00000318902|ensembl:ENSP00000418102|ensembl:ENSP00000419393|ensembl:ENSP00000496990|ensembl:ENSP00000497344|ensembl:ENSP00000497369|uniprotkb:A3QVP8|uniprotkb:Q9BSG9|uniprotkb:B3KV70|uniprotkb:G5E9V8|uniprotkb:Q8NAN6	intact:EBI-983809|uniprotkb:Q9H332|uniprotkb:Q9H333|uniprotkb:Q9P0R1|intact:EBI-28984754|ensembl:ENSP00000318902|ensembl:ENSP00000418102|ensembl:ENSP00000419393|ensembl:ENSP00000496990|ensembl:ENSP00000497344|ensembl:ENSP00000497369|uniprotkb:A3QVP8|uniprotkb:Q9BSG9|uniprotkb:B3KV70|uniprotkb:G5E9V8|uniprotkb:Q8NAN6	psi-mi:foxp1_human(display_long)|uniprotkb:FOXP1(gene name)|psi-mi:FOXP1(display_short)|uniprotkb:Mac-1-regulated forkhead(gene name synonym)|uniprotkb:HSPC215(orf name)	psi-mi:foxp1_human(display_long)|uniprotkb:FOXP1(gene name)|psi-mi:FOXP1(display_short)|uniprotkb:Mac-1-regulated forkhead(gene name synonym)|uniprotkb:HSPC215(orf name)	psi-mi:"MI:0416"(fluorescence microscopy)	Lozano et al. (2015)	imex:IM-28574|pubmed:25853299	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-26565116|imex:IM-28574-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006713165.1|refseq:XP_006713166.1|refseq:XP_006713167.1|go:"GO:0032655"(regulation of interleukin-12 production)|go:"GO:0032680"(regulation of tumor necrosis factor production)|go:"GO:0032651"(regulation of interleukin-1 beta production)|go:"GO:0032745"(positive regulation of interleukin-21 production)|go:"GO:0036035"(osteoclast development)|go:"GO:0042116"(macrophage activation)|go:"GO:0042117"(monocyte activation)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045655"(regulation of monocyte differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0050727"(regulation of inflammatory response)|ensembl:ENSG00000114861(gene)|ensembl:ENST00000318789(transcript)|ensembl:ENST00000475937(transcript)|ensembl:ENST00000498215(transcript)|ensembl:ENST00000648380(transcript)|ensembl:ENST00000649528(transcript)|ensembl:ENST00000649631(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002903"(negative regulation of B cell apoptotic process)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|rcsb pdb:2KIU|reactome:R-HSA-452723|mint:Q9H334|go:"GO:0050861"(positive regulation of B cell receptor signaling pathway)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0061470"(T follicular helper cell differentiation)|go:"GO:1900424"(regulation of defense response to bacterium)|go:"GO:1901256"(regulation of macrophage colony-stimulating factor production)|go:"GO:1901509"(regulation of endothelial tube morphogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000341"("regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR001766(Fork head transcription factor)|interpro:IPR030456|interpro:IPR032354|interpro:IPR036388|interpro:IPR036390|refseq:XP_011531886.1|refseq:XP_011531887.1|refseq:NP_116071.2|refseq:NP_001231743.1|refseq:NP_001231745.1|refseq:NP_001231744.1|refseq:NP_001012523.1|ensembl:ENST00000318779|ensembl:ENSP00000318721|ensembl:ENSP00000318902|ensembl:ENSP00000419393|ensembl:ENST00000484350|ensembl:ENSP00000417857|ensembl:ENST00000493089|ensembl:ENSP00000418524|ensembl:ENSP00000418102|ensembl:ENST00000615603|ensembl:ENSP00000484803|ensembl:ENST00000622151|ensembl:ENSP00000477918|ensembl:ENST00000648107|ensembl:ENSP00000497914|ensembl:ENSP00000497344|ensembl:ENST00000648426|ensembl:ENSP00000498110|ensembl:ENST00000648662|ensembl:ENSP00000496873|ensembl:ENST00000648718|ensembl:ENSP00000496810|ensembl:ENSP00000497369|ensembl:ENSP00000496990|ensembl:ENST00000674446|ensembl:ENSP00000501439|dip:DIP-36585N|refseq:XP_016861654.1|refseq:XP_016861655.1|refseq:XP_016861657.1|refseq:NP_001231741.1|refseq:NP_001231737.1|refseq:NP_001231739.1	refseq:XP_006713165.1|refseq:XP_006713166.1|refseq:XP_006713167.1|go:"GO:0032655"(regulation of interleukin-12 production)|go:"GO:0032680"(regulation of tumor necrosis factor production)|go:"GO:0032651"(regulation of interleukin-1 beta production)|go:"GO:0032745"(positive regulation of interleukin-21 production)|go:"GO:0036035"(osteoclast development)|go:"GO:0042116"(macrophage activation)|go:"GO:0042117"(monocyte activation)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045655"(regulation of monocyte differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0050727"(regulation of inflammatory response)|ensembl:ENSG00000114861(gene)|ensembl:ENST00000318789(transcript)|ensembl:ENST00000475937(transcript)|ensembl:ENST00000498215(transcript)|ensembl:ENST00000648380(transcript)|ensembl:ENST00000649528(transcript)|ensembl:ENST00000649631(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002903"(negative regulation of B cell apoptotic process)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|rcsb pdb:2KIU|reactome:R-HSA-452723|mint:Q9H334|go:"GO:0050861"(positive regulation of B cell receptor signaling pathway)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0061470"(T follicular helper cell differentiation)|go:"GO:1900424"(regulation of defense response to bacterium)|go:"GO:1901256"(regulation of macrophage colony-stimulating factor production)|go:"GO:1901509"(regulation of endothelial tube morphogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000341"("regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR001766(Fork head transcription factor)|interpro:IPR030456|interpro:IPR032354|interpro:IPR036388|interpro:IPR036390|refseq:XP_011531886.1|refseq:XP_011531887.1|refseq:NP_116071.2|refseq:NP_001231743.1|refseq:NP_001231745.1|refseq:NP_001231744.1|refseq:NP_001012523.1|ensembl:ENST00000318779|ensembl:ENSP00000318721|ensembl:ENSP00000318902|ensembl:ENSP00000419393|ensembl:ENST00000484350|ensembl:ENSP00000417857|ensembl:ENST00000493089|ensembl:ENSP00000418524|ensembl:ENSP00000418102|ensembl:ENST00000615603|ensembl:ENSP00000484803|ensembl:ENST00000622151|ensembl:ENSP00000477918|ensembl:ENST00000648107|ensembl:ENSP00000497914|ensembl:ENSP00000497344|ensembl:ENST00000648426|ensembl:ENSP00000498110|ensembl:ENST00000648662|ensembl:ENSP00000496873|ensembl:ENST00000648718|ensembl:ENSP00000496810|ensembl:ENSP00000497369|ensembl:ENSP00000496990|ensembl:ENST00000674446|ensembl:ENSP00000501439|dip:DIP-36585N|refseq:XP_016861654.1|refseq:XP_016861655.1|refseq:XP_016861657.1|refseq:NP_001231741.1|refseq:NP_001231737.1|refseq:NP_001231739.1	go:"GO:0005634"(nucleus)	-	-	figure legend:fig. 2E|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2020/12/15	2020/12/15	rogid:NREo12e1TLPfsul6Ie0l62NqIa89606	rogid:NREo12e1TLPfsul6Ie0l62NqIa89606	rigid:tnb3LF63UiToOd8jT6SYJnrvEQY	false	mcherry fluorescent protein tag:?-?|mutation with complex effect:423-677(rs786200948)	yellow fluorescent protein tag:?-?	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:O15409	uniprotkb:Q9H334	intact:EBI-983612|uniprotkb:A0AUV6|uniprotkb:A4D0U8|uniprotkb:Q6ZND1|uniprotkb:Q75MJ3|uniprotkb:Q8IZE0|uniprotkb:Q8N0W2|uniprotkb:Q8N6B7|uniprotkb:Q8N6B8|uniprotkb:Q8NFQ1|uniprotkb:Q8NFQ2|uniprotkb:Q8NFQ3|uniprotkb:Q8NFQ4|uniprotkb:Q8TD74|ensembl:ENSP00000265436|ensembl:ENSP00000377132|uniprotkb:A6NNW4|uniprotkb:B4DLD9	intact:EBI-983809|uniprotkb:Q9H332|uniprotkb:Q9H333|uniprotkb:Q9P0R1|intact:EBI-28984754|ensembl:ENSP00000318902|ensembl:ENSP00000418102|ensembl:ENSP00000419393|ensembl:ENSP00000496990|ensembl:ENSP00000497344|ensembl:ENSP00000497369|uniprotkb:A3QVP8|uniprotkb:Q9BSG9|uniprotkb:B3KV70|uniprotkb:G5E9V8|uniprotkb:Q8NAN6	psi-mi:foxp2_human(display_long)|uniprotkb:CAG repeat protein 44(gene name synonym)|uniprotkb:Trinucleotide repeat-containing gene 10 protein(gene name synonym)|uniprotkb:FOXP2(gene name)|psi-mi:FOXP2(display_short)|uniprotkb:CAGH44(gene name synonym)|uniprotkb:TNRC10(gene name synonym)	psi-mi:foxp1_human(display_long)|uniprotkb:FOXP1(gene name)|psi-mi:FOXP1(display_short)|uniprotkb:Mac-1-regulated forkhead(gene name synonym)|uniprotkb:HSPC215(orf name)	psi-mi:"MI:0416"(fluorescence microscopy)	Lozano et al. (2015)	imex:IM-28574|pubmed:25853299	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-26565104|imex:IM-28574-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000128573(gene)|ensembl:ENST00000350908(transcript)|ensembl:ENST00000393494(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0021757"(caudate nucleus development)|go:"GO:0021758"(putamen development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0033574"(response to testosterone)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0098582"(innate vocalization behavior)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR030456|interpro:IPR032354|interpro:IPR036388|interpro:IPR036390|mint:O15409|rcsb pdb:2A07|rcsb pdb:2AS5|go:"GO:0046872"(metal ion binding)|refseq:NP_001166237.1|refseq:NP_001166238.1|refseq:NP_055306.1|refseq:NP_683696.2|refseq:NP_683697.2|refseq:NP_683698.2|dip:DIP-29004N|refseq:XP_016868290.1	refseq:XP_006713165.1|refseq:XP_006713166.1|refseq:XP_006713167.1|go:"GO:0032655"(regulation of interleukin-12 production)|go:"GO:0032680"(regulation of tumor necrosis factor production)|go:"GO:0032651"(regulation of interleukin-1 beta production)|go:"GO:0032745"(positive regulation of interleukin-21 production)|go:"GO:0036035"(osteoclast development)|go:"GO:0042116"(macrophage activation)|go:"GO:0042117"(monocyte activation)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045655"(regulation of monocyte differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0050727"(regulation of inflammatory response)|ensembl:ENSG00000114861(gene)|ensembl:ENST00000318789(transcript)|ensembl:ENST00000475937(transcript)|ensembl:ENST00000498215(transcript)|ensembl:ENST00000648380(transcript)|ensembl:ENST00000649528(transcript)|ensembl:ENST00000649631(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002903"(negative regulation of B cell apoptotic process)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|rcsb pdb:2KIU|reactome:R-HSA-452723|mint:Q9H334|go:"GO:0050861"(positive regulation of B cell receptor signaling pathway)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0061470"(T follicular helper cell differentiation)|go:"GO:1900424"(regulation of defense response to bacterium)|go:"GO:1901256"(regulation of macrophage colony-stimulating factor production)|go:"GO:1901509"(regulation of endothelial tube morphogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000341"("regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR001766(Fork head transcription factor)|interpro:IPR030456|interpro:IPR032354|interpro:IPR036388|interpro:IPR036390|refseq:XP_011531886.1|refseq:XP_011531887.1|refseq:NP_116071.2|refseq:NP_001231743.1|refseq:NP_001231745.1|refseq:NP_001231744.1|refseq:NP_001012523.1|ensembl:ENST00000318779|ensembl:ENSP00000318721|ensembl:ENSP00000318902|ensembl:ENSP00000419393|ensembl:ENST00000484350|ensembl:ENSP00000417857|ensembl:ENST00000493089|ensembl:ENSP00000418524|ensembl:ENSP00000418102|ensembl:ENST00000615603|ensembl:ENSP00000484803|ensembl:ENST00000622151|ensembl:ENSP00000477918|ensembl:ENST00000648107|ensembl:ENSP00000497914|ensembl:ENSP00000497344|ensembl:ENST00000648426|ensembl:ENSP00000498110|ensembl:ENST00000648662|ensembl:ENSP00000496873|ensembl:ENST00000648718|ensembl:ENSP00000496810|ensembl:ENSP00000497369|ensembl:ENSP00000496990|ensembl:ENST00000674446|ensembl:ENSP00000501439|dip:DIP-36585N|refseq:XP_016861654.1|refseq:XP_016861655.1|refseq:XP_016861657.1|refseq:NP_001231741.1|refseq:NP_001231737.1|refseq:NP_001231739.1	go:"GO:0005634"(nucleus)	-	-	figure legend:fig. 2E|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2020/12/15	2020/12/15	rogid:XRN9auLs2qtK6W3mjHJHAQPbO9s9606	rogid:NREo12e1TLPfsul6Ie0l62NqIa89606	rigid:zXjmRyOSMZge1sszh6NclUm6d5M	false	yellow fluorescent protein tag:?-?	mcherry fluorescent protein tag:?-?|mutation with complex effect:423-677(rs786200948)	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)