#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q1HG44	uniprotkb:Q9NRD8	intact:EBI-25589731|ensembl:ENSP00000319705|uniprotkb:B2RPI9|uniprotkb:H0YNQ6	intact:EBI-12740885|ensembl:ENSP00000475084|uniprotkb:A8MQ13|uniprotkb:D2XI64|uniprotkb:Q9NR02|uniprotkb:Q9UHF9	psi-mi:doxa2_human(display_long)|uniprotkb:DUOXA2(gene name)|psi-mi:DUOXA2(display_short)|uniprotkb:Dual oxidase activator 2(gene name synonym)	psi-mi:duox2_human(display_long)|uniprotkb:DUOX2(gene name)|psi-mi:DUOX2(display_short)|uniprotkb:LNOX2(gene name synonym)|uniprotkb:THOX2(gene name synonym)|uniprotkb:Large NOX 2(gene name synonym)|uniprotkb:Long NOX 2(gene name synonym)|uniprotkb:NADH/NADPH thyroid oxidase p138-tox(gene name synonym)|uniprotkb:NADPH oxidase/peroxidase DUOX2(gene name synonym)|uniprotkb:NADPH thyroid oxidase 2(gene name synonym)|uniprotkb:Thyroid oxidase 2(gene name synonym)|uniprotkb:p138 thyroid oxidase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Carré et al. (2015)	pubmed:25761904|imex:IM-28137	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-25589762|imex:IM-28137-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005789"(endoplasmic reticulum membrane)|ensembl:ENSG00000140274(gene)|ensembl:ENST00000323030(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0031252"(cell leading edge)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042743"(hydrogen peroxide metabolic process)|go:"GO:0045177"(apical part of cell)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051604"(protein maturation)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000609"(regulation of thyroid hormone generation)|interpro:IPR018469|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008104"(protein localization)|go:"GO:0010729"(positive regulation of hydrogen peroxide biosynthetic process)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|refseq:NP_997464.2	ensembl:ENSG00000140279(gene)|ensembl:ENST00000603300(transcript)|go:"GO:0004601"(peroxidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006590"(thyroid hormone generation)|go:"GO:0006952"(defense response)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0009615"(response to virus)|go:"GO:0009986"(cell surface)|go:"GO:0016174"("NAD(P)H oxidase H2O2-forming activity")|go:"GO:0016175"("superoxide-generating NAD(P)H oxidase activity")|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0020037"(heme binding)|go:"GO:0030054"(cell junction)|go:"GO:0031252"(cell leading edge)|go:"GO:0042335"(cuticle development)|go:"GO:0042446"(hormone biosynthetic process)|go:"GO:0042554"(superoxide anion generation)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0043020"(NADPH oxidase complex)|go:"GO:0045177"(apical part of cell)|go:"GO:0050665"(hydrogen peroxide biosynthetic process)|go:"GO:0051591"(response to cAMP)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0106293"(NADH oxidase H202-forming activity)|go:"GO:0106294"(NADPH oxidase H202-forming activity)|go:"GO:2000147"(positive regulation of cell motility)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR010255(Haem peroxidase)|interpro:IPR011992(EF-Hand type)|interpro:IPR013112(FAD-binding 8)|interpro:IPR013121(Ferric reductase, NAD binding)|interpro:IPR013130(Ferric reductase-like transmembrane component, N-terminal)|interpro:IPR017927|interpro:IPR017938|interpro:IPR018247|interpro:IPR019791|interpro:IPR034818|interpro:IPR034821|interpro:IPR037120|interpro:IPR039261|reactome:R-HSA-209968|refseq:NP_054799.4	-	-	-	figure legend:Fig. 3A, Supp. Fig. 1B|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2020/04/26	2020/04/27	rogid:UEuv74mEuNDFBgKjJzXaYAsfYMY9606	rogid:CxjD4JIZ06U8HhY1yDN66mgp8T89606	rigid:zMQpZGZdT15+ua4dhQZGryEpDr8	false	-	mutation disrupting interaction strength:124-124	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q1HG44	uniprotkb:Q9NRD8	intact:EBI-25589731|ensembl:ENSP00000319705|uniprotkb:B2RPI9|uniprotkb:H0YNQ6	intact:EBI-12740885|ensembl:ENSP00000475084|uniprotkb:A8MQ13|uniprotkb:D2XI64|uniprotkb:Q9NR02|uniprotkb:Q9UHF9	psi-mi:doxa2_human(display_long)|uniprotkb:DUOXA2(gene name)|psi-mi:DUOXA2(display_short)|uniprotkb:Dual oxidase activator 2(gene name synonym)	psi-mi:duox2_human(display_long)|uniprotkb:DUOX2(gene name)|psi-mi:DUOX2(display_short)|uniprotkb:LNOX2(gene name synonym)|uniprotkb:THOX2(gene name synonym)|uniprotkb:Large NOX 2(gene name synonym)|uniprotkb:Long NOX 2(gene name synonym)|uniprotkb:NADH/NADPH thyroid oxidase p138-tox(gene name synonym)|uniprotkb:NADPH oxidase/peroxidase DUOX2(gene name synonym)|uniprotkb:NADPH thyroid oxidase 2(gene name synonym)|uniprotkb:Thyroid oxidase 2(gene name synonym)|uniprotkb:p138 thyroid oxidase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Carré et al. (2015)	pubmed:25761904|imex:IM-28137	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-25589819|imex:IM-28137-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005789"(endoplasmic reticulum membrane)|ensembl:ENSG00000140274(gene)|ensembl:ENST00000323030(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0031252"(cell leading edge)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042743"(hydrogen peroxide metabolic process)|go:"GO:0045177"(apical part of cell)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051604"(protein maturation)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000609"(regulation of thyroid hormone generation)|interpro:IPR018469|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008104"(protein localization)|go:"GO:0010729"(positive regulation of hydrogen peroxide biosynthetic process)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|refseq:NP_997464.2	ensembl:ENSG00000140279(gene)|ensembl:ENST00000603300(transcript)|go:"GO:0004601"(peroxidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006590"(thyroid hormone generation)|go:"GO:0006952"(defense response)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0009615"(response to virus)|go:"GO:0009986"(cell surface)|go:"GO:0016174"("NAD(P)H oxidase H2O2-forming activity")|go:"GO:0016175"("superoxide-generating NAD(P)H oxidase activity")|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0020037"(heme binding)|go:"GO:0030054"(cell junction)|go:"GO:0031252"(cell leading edge)|go:"GO:0042335"(cuticle development)|go:"GO:0042446"(hormone biosynthetic process)|go:"GO:0042554"(superoxide anion generation)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0043020"(NADPH oxidase complex)|go:"GO:0045177"(apical part of cell)|go:"GO:0050665"(hydrogen peroxide biosynthetic process)|go:"GO:0051591"(response to cAMP)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0106293"(NADH oxidase H202-forming activity)|go:"GO:0106294"(NADPH oxidase H202-forming activity)|go:"GO:2000147"(positive regulation of cell motility)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR010255(Haem peroxidase)|interpro:IPR011992(EF-Hand type)|interpro:IPR013112(FAD-binding 8)|interpro:IPR013121(Ferric reductase, NAD binding)|interpro:IPR013130(Ferric reductase-like transmembrane component, N-terminal)|interpro:IPR017927|interpro:IPR017938|interpro:IPR018247|interpro:IPR019791|interpro:IPR034818|interpro:IPR034821|interpro:IPR037120|interpro:IPR039261|reactome:R-HSA-209968|refseq:NP_054799.4	-	-	-	figure legend:Fig. 3C|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2020/04/26	2020/04/27	rogid:UEuv74mEuNDFBgKjJzXaYAsfYMY9606	rogid:CxjD4JIZ06U8HhY1yDN66mgp8T89606	rigid:zMQpZGZdT15+ua4dhQZGryEpDr8	false	myc tag:c-c	mutation disrupting interaction strength:124-124|mutation with no effect:351-351|mutation decreasing interaction strength:370-370|mutation disrupting interaction strength:568-568|mutation disrupting interaction strength:582-582	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q1HG44	uniprotkb:Q9NRD8	intact:EBI-25589731|ensembl:ENSP00000319705|uniprotkb:B2RPI9|uniprotkb:H0YNQ6	intact:EBI-12740885|ensembl:ENSP00000475084|uniprotkb:A8MQ13|uniprotkb:D2XI64|uniprotkb:Q9NR02|uniprotkb:Q9UHF9	psi-mi:doxa2_human(display_long)|uniprotkb:DUOXA2(gene name)|psi-mi:DUOXA2(display_short)|uniprotkb:Dual oxidase activator 2(gene name synonym)	psi-mi:duox2_human(display_long)|uniprotkb:DUOX2(gene name)|psi-mi:DUOX2(display_short)|uniprotkb:LNOX2(gene name synonym)|uniprotkb:THOX2(gene name synonym)|uniprotkb:Large NOX 2(gene name synonym)|uniprotkb:Long NOX 2(gene name synonym)|uniprotkb:NADH/NADPH thyroid oxidase p138-tox(gene name synonym)|uniprotkb:NADPH oxidase/peroxidase DUOX2(gene name synonym)|uniprotkb:NADPH thyroid oxidase 2(gene name synonym)|uniprotkb:Thyroid oxidase 2(gene name synonym)|uniprotkb:p138 thyroid oxidase(gene name synonym)	psi-mi:"MI:0404"(comigration in non denaturing gel electrophoresis)	Carré et al. (2015)	pubmed:25761904|imex:IM-28137	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-25589940|imex:IM-28137-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005789"(endoplasmic reticulum membrane)|ensembl:ENSG00000140274(gene)|ensembl:ENST00000323030(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0031252"(cell leading edge)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042743"(hydrogen peroxide metabolic process)|go:"GO:0045177"(apical part of cell)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051604"(protein maturation)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000609"(regulation of thyroid hormone generation)|interpro:IPR018469|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008104"(protein localization)|go:"GO:0010729"(positive regulation of hydrogen peroxide biosynthetic process)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|refseq:NP_997464.2	ensembl:ENSG00000140279(gene)|ensembl:ENST00000603300(transcript)|go:"GO:0004601"(peroxidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006590"(thyroid hormone generation)|go:"GO:0006952"(defense response)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0009615"(response to virus)|go:"GO:0009986"(cell surface)|go:"GO:0016174"("NAD(P)H oxidase H2O2-forming activity")|go:"GO:0016175"("superoxide-generating NAD(P)H oxidase activity")|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0020037"(heme binding)|go:"GO:0030054"(cell junction)|go:"GO:0031252"(cell leading edge)|go:"GO:0042335"(cuticle development)|go:"GO:0042446"(hormone biosynthetic process)|go:"GO:0042554"(superoxide anion generation)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0043020"(NADPH oxidase complex)|go:"GO:0045177"(apical part of cell)|go:"GO:0050665"(hydrogen peroxide biosynthetic process)|go:"GO:0051591"(response to cAMP)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0106293"(NADH oxidase H202-forming activity)|go:"GO:0106294"(NADPH oxidase H202-forming activity)|go:"GO:2000147"(positive regulation of cell motility)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR010255(Haem peroxidase)|interpro:IPR011992(EF-Hand type)|interpro:IPR013112(FAD-binding 8)|interpro:IPR013121(Ferric reductase, NAD binding)|interpro:IPR013130(Ferric reductase-like transmembrane component, N-terminal)|interpro:IPR017927|interpro:IPR017938|interpro:IPR018247|interpro:IPR019791|interpro:IPR034818|interpro:IPR034821|interpro:IPR037120|interpro:IPR039261|reactome:R-HSA-209968|refseq:NP_054799.4	-	-	-	figure legend:Fig. 3B|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2020/04/26	2020/04/27	rogid:UEuv74mEuNDFBgKjJzXaYAsfYMY9606	rogid:CxjD4JIZ06U8HhY1yDN66mgp8T89606	rigid:zMQpZGZdT15+ua4dhQZGryEpDr8	false	myc tag:c-c	mutation disrupting interaction strength:124-124	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q1HG44	uniprotkb:Q9NRD8	intact:EBI-25589731|ensembl:ENSP00000319705|uniprotkb:B2RPI9|uniprotkb:H0YNQ6	intact:EBI-12740885|ensembl:ENSP00000475084|uniprotkb:A8MQ13|uniprotkb:D2XI64|uniprotkb:Q9NR02|uniprotkb:Q9UHF9	psi-mi:doxa2_human(display_long)|uniprotkb:DUOXA2(gene name)|psi-mi:DUOXA2(display_short)|uniprotkb:Dual oxidase activator 2(gene name synonym)	psi-mi:duox2_human(display_long)|uniprotkb:DUOX2(gene name)|psi-mi:DUOX2(display_short)|uniprotkb:LNOX2(gene name synonym)|uniprotkb:THOX2(gene name synonym)|uniprotkb:Large NOX 2(gene name synonym)|uniprotkb:Long NOX 2(gene name synonym)|uniprotkb:NADH/NADPH thyroid oxidase p138-tox(gene name synonym)|uniprotkb:NADPH oxidase/peroxidase DUOX2(gene name synonym)|uniprotkb:NADPH thyroid oxidase 2(gene name synonym)|uniprotkb:Thyroid oxidase 2(gene name synonym)|uniprotkb:p138 thyroid oxidase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Carré et al. (2015)	pubmed:25761904|imex:IM-28137	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-25590185|imex:IM-28137-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005789"(endoplasmic reticulum membrane)|ensembl:ENSG00000140274(gene)|ensembl:ENST00000323030(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0031252"(cell leading edge)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042743"(hydrogen peroxide metabolic process)|go:"GO:0045177"(apical part of cell)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051604"(protein maturation)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000609"(regulation of thyroid hormone generation)|interpro:IPR018469|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008104"(protein localization)|go:"GO:0010729"(positive regulation of hydrogen peroxide biosynthetic process)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|refseq:NP_997464.2	ensembl:ENSG00000140279(gene)|ensembl:ENST00000603300(transcript)|go:"GO:0004601"(peroxidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006590"(thyroid hormone generation)|go:"GO:0006952"(defense response)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0009615"(response to virus)|go:"GO:0009986"(cell surface)|go:"GO:0016174"("NAD(P)H oxidase H2O2-forming activity")|go:"GO:0016175"("superoxide-generating NAD(P)H oxidase activity")|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0020037"(heme binding)|go:"GO:0030054"(cell junction)|go:"GO:0031252"(cell leading edge)|go:"GO:0042335"(cuticle development)|go:"GO:0042446"(hormone biosynthetic process)|go:"GO:0042554"(superoxide anion generation)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0043020"(NADPH oxidase complex)|go:"GO:0045177"(apical part of cell)|go:"GO:0050665"(hydrogen peroxide biosynthetic process)|go:"GO:0051591"(response to cAMP)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0106293"(NADH oxidase H202-forming activity)|go:"GO:0106294"(NADPH oxidase H202-forming activity)|go:"GO:2000147"(positive regulation of cell motility)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR010255(Haem peroxidase)|interpro:IPR011992(EF-Hand type)|interpro:IPR013112(FAD-binding 8)|interpro:IPR013121(Ferric reductase, NAD binding)|interpro:IPR013130(Ferric reductase-like transmembrane component, N-terminal)|interpro:IPR017927|interpro:IPR017938|interpro:IPR018247|interpro:IPR019791|interpro:IPR034818|interpro:IPR034821|interpro:IPR037120|interpro:IPR039261|reactome:R-HSA-209968|refseq:NP_054799.4	-	-	-	figure legend:Fig. 4C|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2020/04/26	2020/04/27	rogid:UEuv74mEuNDFBgKjJzXaYAsfYMY9606	rogid:CxjD4JIZ06U8HhY1yDN66mgp8T89606	rigid:zMQpZGZdT15+ua4dhQZGryEpDr8	false	myc tag:c-c	mutation disrupting interaction strength:1162-1162|ha tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q1HG44	uniprotkb:Q9NRD8	intact:EBI-25589731|ensembl:ENSP00000319705|uniprotkb:B2RPI9|uniprotkb:H0YNQ6	intact:EBI-12740885|ensembl:ENSP00000475084|uniprotkb:A8MQ13|uniprotkb:D2XI64|uniprotkb:Q9NR02|uniprotkb:Q9UHF9	psi-mi:doxa2_human(display_long)|uniprotkb:DUOXA2(gene name)|psi-mi:DUOXA2(display_short)|uniprotkb:Dual oxidase activator 2(gene name synonym)	psi-mi:duox2_human(display_long)|uniprotkb:DUOX2(gene name)|psi-mi:DUOX2(display_short)|uniprotkb:LNOX2(gene name synonym)|uniprotkb:THOX2(gene name synonym)|uniprotkb:Large NOX 2(gene name synonym)|uniprotkb:Long NOX 2(gene name synonym)|uniprotkb:NADH/NADPH thyroid oxidase p138-tox(gene name synonym)|uniprotkb:NADPH oxidase/peroxidase DUOX2(gene name synonym)|uniprotkb:NADPH thyroid oxidase 2(gene name synonym)|uniprotkb:Thyroid oxidase 2(gene name synonym)|uniprotkb:p138 thyroid oxidase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Carré et al. (2015)	pubmed:25761904|imex:IM-28137	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-25590243|imex:IM-28137-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005789"(endoplasmic reticulum membrane)|ensembl:ENSG00000140274(gene)|ensembl:ENST00000323030(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0031252"(cell leading edge)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042743"(hydrogen peroxide metabolic process)|go:"GO:0045177"(apical part of cell)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051604"(protein maturation)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000609"(regulation of thyroid hormone generation)|interpro:IPR018469|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008104"(protein localization)|go:"GO:0010729"(positive regulation of hydrogen peroxide biosynthetic process)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|refseq:NP_997464.2	ensembl:ENSG00000140279(gene)|ensembl:ENST00000603300(transcript)|go:"GO:0004601"(peroxidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006590"(thyroid hormone generation)|go:"GO:0006952"(defense response)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0009615"(response to virus)|go:"GO:0009986"(cell surface)|go:"GO:0016174"("NAD(P)H oxidase H2O2-forming activity")|go:"GO:0016175"("superoxide-generating NAD(P)H oxidase activity")|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0020037"(heme binding)|go:"GO:0030054"(cell junction)|go:"GO:0031252"(cell leading edge)|go:"GO:0042335"(cuticle development)|go:"GO:0042446"(hormone biosynthetic process)|go:"GO:0042554"(superoxide anion generation)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0043020"(NADPH oxidase complex)|go:"GO:0045177"(apical part of cell)|go:"GO:0050665"(hydrogen peroxide biosynthetic process)|go:"GO:0051591"(response to cAMP)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0106293"(NADH oxidase H202-forming activity)|go:"GO:0106294"(NADPH oxidase H202-forming activity)|go:"GO:2000147"(positive regulation of cell motility)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR010255(Haem peroxidase)|interpro:IPR011992(EF-Hand type)|interpro:IPR013112(FAD-binding 8)|interpro:IPR013121(Ferric reductase, NAD binding)|interpro:IPR013130(Ferric reductase-like transmembrane component, N-terminal)|interpro:IPR017927|interpro:IPR017938|interpro:IPR018247|interpro:IPR019791|interpro:IPR034818|interpro:IPR034821|interpro:IPR037120|interpro:IPR039261|reactome:R-HSA-209968|refseq:NP_054799.4	-	-	-	figure legend:Fig. 5D|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2020/04/26	2020/04/27	rogid:UEuv74mEuNDFBgKjJzXaYAsfYMY9606	rogid:CxjD4JIZ06U8HhY1yDN66mgp8T89606	rigid:zMQpZGZdT15+ua4dhQZGryEpDr8	false	mutation disrupting interaction strength:233-233|myc tag:c-c|mutation disrupting interaction strength:167-167	ha tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)