#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P27487 uniprotkb:K9N5Q8 intact:EBI-2871277|uniprotkb:Q53TN1|ensembl:ENSP00000353731 intact:EBI-25474996 psi-mi:dpp4_human(display_long)|uniprotkb:DPP4(gene name)|psi-mi:DPP4(display_short)|uniprotkb:ADCP2(gene name synonym)|uniprotkb:CD26(gene name synonym)|uniprotkb:ADABP(gene name synonym)|uniprotkb:Adenosine deaminase complexing protein 2(gene name synonym)|uniprotkb:Dipeptidyl peptidase IV(gene name synonym)|uniprotkb:T-cell activation antigen CD26(gene name synonym)|uniprotkb:TP103(gene name synonym) psi-mi:spike_mers1(display_long)|uniprotkb:E2(gene name synonym)|uniprotkb:Peplomer protein(gene name synonym)|uniprotkb:3(orf name)|uniprotkb:S(gene name)|psi-mi:S(display_short) psi-mi:"MI:0107"(surface plasmon resonance) Song et al. (2014) imex:IM-28333|pubmed:25461530 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:1263720(cvemc)|taxid:1263720("Middle East respiratory syndrome-related coronavirus (isolate United Kingdom/H123990006/2012) (Betacoronavirus England 1)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-25827610|imex:IM-28333-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001926.2|dip:DIP-351N|ensembl:ENSG00000197635(gene)|ensembl:ENST00000360534(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002020"(protease binding)|go:"GO:0004177"(aminopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0007155"(cell adhesion)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008239"(dipeptidyl-peptidase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010716"(negative regulation of extracellular matrix disassembly)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0033632"(regulation of cell-cell adhesion mediated by integrin)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0036343"(psychomotor behavior)|go:"GO:0042110"(T cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045121"(membrane raft)|go:"GO:0045499"(chemorepellent activity)|go:"GO:0046581"(intercellular canaliculus)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090024"(negative regulation of neutrophil chemotaxis)|interpro:IPR001375(Peptidase S9, prolyl oligopeptidase active site region)|interpro:IPR002469(Peptidase S9B, dipeptidylpeptidase IV N-terminal)|interpro:IPR002471(Peptidase S9, serine active site)|interpro:IPR029058|mint:P27487|rcsb pdb:1J2E|rcsb pdb:1N1M|rcsb pdb:1NU6|rcsb pdb:1NU8|rcsb pdb:1PFQ|rcsb pdb:1R9M|rcsb pdb:1R9N|rcsb pdb:1RWQ|rcsb pdb:1TK3|rcsb pdb:1TKR|rcsb pdb:1U8E|rcsb pdb:1W1I|rcsb pdb:1WCY|rcsb pdb:1X70|rcsb pdb:2AJL|rcsb pdb:2BGN|rcsb pdb:2BGR|rcsb pdb:2BUB|rcsb pdb:2FJP|rcsb pdb:2G5P|rcsb pdb:2G5T|rcsb pdb:2G63|rcsb pdb:2HHA|rcsb pdb:2I03|rcsb pdb:2I78|rcsb pdb:2IIV|rcsb pdb:2JID|rcsb pdb:2OAG|rcsb pdb:2OGZ|rcsb pdb:2OLE|rcsb pdb:2ONC|rcsb pdb:2OPH|rcsb pdb:2OQI|rcsb pdb:2OQV|rcsb pdb:2P8S|rcsb pdb:2QJR|rcsb pdb:2QKY|rcsb pdb:2QOE|rcsb pdb:2QT9|rcsb pdb:2IIT|rcsb pdb:2QTB|rcsb pdb:2RGU|rcsb pdb:2RIP|rcsb pdb:3BJM|rcsb pdb:3C43|rcsb pdb:3C45|rcsb pdb:3CCB|rcsb pdb:3CCC|rcsb pdb:3D4L|rcsb pdb:3EIO|rcsb pdb:3F8S|rcsb pdb:3G0B|rcsb pdb:3G0C|rcsb pdb:3G0D|rcsb pdb:3G0G|rcsb pdb:3H0C|rcsb pdb:3HAB|rcsb pdb:3HAC|rcsb pdb:3KWF|rcsb pdb:3KWJ|rcsb pdb:3NOX|rcsb pdb:3O95|rcsb pdb:3O9V|rcsb pdb:3OC0|rcsb pdb:3OPM|rcsb pdb:3Q0T|rcsb pdb:3Q8W|rcsb pdb:3SWW|rcsb pdb:3SX4|rcsb pdb:3VJK|rcsb pdb:3VJL|rcsb pdb:3VJM|rcsb pdb:3W2T|rcsb pdb:3WQH|rcsb pdb:4A5S|rcsb pdb:4DSA|rcsb pdb:4DSZ|rcsb pdb:4DTC|rcsb pdb:4G1F|rcsb pdb:4J3J|rcsb pdb:4JH0|rcsb pdb:4KR0|rcsb pdb:4L72|rcsb pdb:4LKO|rcsb pdb:4N8D|rcsb pdb:4N8E|rcsb pdb:4PNZ|rcsb pdb:4PV7|rcsb pdb:4QZV|rcsb pdb:5I7U|rcsb pdb:5ISM|rcsb pdb:5J3J|rcsb pdb:5KBY|rcsb pdb:5T4B|rcsb pdb:5T4E|rcsb pdb:5T4F|rcsb pdb:5T4H|rcsb pdb:5Y7H|rcsb pdb:5Y7J|rcsb pdb:5Y7K|rcsb pdb:5ZID|rcsb pdb:6B1E|rcsb pdb:6B1O|reactome:R-HSA-381771|reactome:R-HSA-400511|rcsb pdb:3QBJ interpro:IPR043002|interpro:IPR044873|interpro:IPR044874|rcsb pdb:7M55|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0044173"(host cell endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|interpro:IPR043473|rcsb pdb:7C02|interpro:IPR044337|interpro:IPR044376|rcsb pdb:6J11|rcsb pdb:6J2J|rcsb pdb:4L72|rcsb pdb:4MOD|rcsb pdb:4XAK|rcsb pdb:4ZPT|rcsb pdb:4ZPV|rcsb pdb:4ZPW|rcsb pdb:5GMQ|rcsb pdb:5GR7|rcsb pdb:5GSB|rcsb pdb:5GSR|rcsb pdb:5GSV|rcsb pdb:5GSX|rcsb pdb:5VYH|rcsb pdb:5W9H|rcsb pdb:5W9I|rcsb pdb:5W9J|rcsb pdb:5W9K|rcsb pdb:5W9L|rcsb pdb:5W9M|rcsb pdb:5W9N|rcsb pdb:5W9O|rcsb pdb:5W9P|rcsb pdb:5X4R|rcsb pdb:5X59|rcsb pdb:5X5C|rcsb pdb:5X5F|rcsb pdb:5YY5|rcsb pdb:5ZVK|rcsb pdb:5ZXV|rcsb pdb:6C6Y|rcsb pdb:6C6Z|interpro:IPR042578|interpro:IPR002552(Coronavirus S2 glycoprotein)|interpro:IPR018548|interpro:IPR036326|rcsb pdb:6PXH|interpro:IPR032500|interpro:IPR043607|interpro:IPR043614|rcsb pdb:6L8Q|rcsb pdb:6WAR - - - figure legend:Figure 2, Table 1.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:1.2x10^-8(molar) 2020/09/08 2020/09/11 rogid:D8cgqdBbAfEQk+G2GhDuJvrkBcE9606 rogid:6bq0dCMRZIrh+JDav4MxdGChyEg1263720 rigid:dxhhwvfLARtemaVN7+ExQ8KUxtI false tag:n-n|his tag:c-c|mutation disrupting interaction strength:267-267|mutation decreasing interaction strength:336-336|mutation with no effect:344-344|mutation disrupting interaction strength:267-267|mutation disrupting interaction strength:294-295|mutation disrupting interaction strength:294-295|mutation decreasing interaction strength:317-317|sufficient binding region:39-766 tag:n-n|his tag:c-c|sufficient binding region:367-606 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)