#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P05231	uniprotkb:Q99523	intact:EBI-720533|uniprotkb:Q9UCU4|uniprotkb:Q9UCU2|uniprotkb:Q9UCU3|ensembl:ENSP00000258743|ensembl:ENSP00000385675	intact:EBI-1057058|uniprotkb:Q8IZ49|uniprotkb:C0JYZ0|uniprotkb:B4DWI3|ensembl:ENSP00000256637	psi-mi:il6_human(display_long)|uniprotkb:B-cell stimulatory factor 2(gene name synonym)|uniprotkb:Interferon beta-2(gene name synonym)|uniprotkb:Hybridoma growth factor(gene name synonym)|uniprotkb:CTL differentiation factor(gene name synonym)|uniprotkb:IL6(gene name)|psi-mi:IL6(display_short)|uniprotkb:IFNB2(gene name synonym)	psi-mi:sort_human(display_long)|uniprotkb:SORT1(gene name)|psi-mi:SORT1(display_short)|uniprotkb:Neurotensin receptor 3(gene name synonym)|uniprotkb:Glycoprotein 95(gene name synonym)|uniprotkb:100 kDa NT receptor(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Mortensen et al. (2014)	pubmed:25401472|imex:IM-27639	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25396627|imex:IM-27639-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0001781"(neutrophil apoptotic process)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0050871"(positive regulation of B cell activation)|refseq:NP_000591.1|refseq:XP_011513692.1|dip:DIP-482N|ensembl:ENSG00000136244(gene)|ensembl:ENST00000258743(transcript)|ensembl:ENST00000404625(transcript)|go:"GO:0002384"(hepatic immune response)|go:"GO:0002446"(neutrophil mediated immunity)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0002675"(positive regulation of acute inflammatory response)|go:"GO:0002690"(positive regulation of leukocyte chemotaxis)|go:"GO:0005125"(cytokine activity)|go:"GO:0005138"(interleukin-6 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005896"(interleukin-6 receptor complex)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0002314"(germinal center B cell differentiation)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010574"(regulation of vascular endothelial growth factor production)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0014823"(response to activity)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030168"(platelet activation)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0031175"(neuron projection development)|go:"GO:0032494"(response to peptidoglycan)|go:"GO:0032682"(negative regulation of chemokine production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032745"(positive regulation of interleukin-21 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032966"(negative regulation of collagen biosynthetic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051607"(defense response to virus)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0061470"(T follicular helper cell differentiation)|go:"GO:0061888"(regulation of astrocyte activation)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070091"(glucagon secretion)|go:"GO:0070092"(regulation of glucagon secretion)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0072574"(hepatocyte proliferation)|go:"GO:0090091"(positive regulation of extracellular matrix disassembly)|go:"GO:0097421"(liver regeneration)|go:"GO:0098586"(cellular response to virus)|go:"GO:0150077"(regulation of neuroinflammatory response)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901731"(positive regulation of platelet aggregation)|go:"GO:1902512"(positive regulation of apoptotic DNA fragmentation)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903978"(regulation of microglial cell activation)|go:"GO:1904894"(positive regulation of receptor signaling pathway via STAT)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000660"(negative regulation of interleukin-1-mediated signaling pathway)|go:"GO:2000676"(positive regulation of type B pancreatic cell apoptotic process)|interpro:IPR003574(Interleukin-6)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR030473|interpro:IPR030474|rcsb pdb:1ALU|rcsb pdb:1IL6|rcsb pdb:1N2Q|rcsb pdb:1P9M|rcsb pdb:2IL6|rcsb pdb:4CNI|rcsb pdb:4J4L|rcsb pdb:4NI7|rcsb pdb:4NI9|rcsb pdb:4O9H|rcsb pdb:4ZS7|rcsb pdb:5FUC|rcsb pdb:7NXZ|reactome:R-HSA-1059683|reactome:R-HSA-110056|reactome:R-HSA-112411|reactome:R-HSA-2559582|reactome:R-HSA-381426|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8853884|reactome:R-HSA-8957275|reactome:R-HSA-9660821|reactome:R-HSA-9662834	refseq:NP_001192157.1|refseq:NP_002950.3|ensembl:ENSG00000134243(gene)|ensembl:ENST00000256637(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0006895"(Golgi to endosome transport)|go:"GO:0006897"(endocytosis)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010465"(nerve growth factor receptor activity)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014902"(myotube differentiation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016050"(vesicle organization)|go:"GO:0019899"(enzyme binding)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030379"(neurotensin receptor activity, non-G protein-coupled)|go:"GO:0030425"(dendrite)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032509"(endosome transport via multivesicular body sorting pathway)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0046323"(glucose import)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048227"(plasma membrane to endosome transport)|go:"GO:0048406"(nerve growth factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051005"(negative regulation of lipoprotein lipase activity)|go:"GO:0090160"(Golgi to lysosome transport)|go:"GO:1904037"(positive regulation of epithelial cell apoptotic process)|go:"GO:1905394"(retromer complex binding)|interpro:IPR006581(VPS10)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR031777|interpro:IPR031778|mint:Q99523|rcsb pdb:3F6K|rcsb pdb:3G2U|rcsb pdb:3G2V|rcsb pdb:4MSL|rcsb pdb:4N7E|rcsb pdb:4PO7|rcsb pdb:5MRH|rcsb pdb:5MRI|rcsb pdb:6EHO|rcsb pdb:6X3L|rcsb pdb:6X48|rcsb pdb:6X4H|reactome:R-HSA-432722|go:"GO:0032868"(response to insulin)|dip:DIP-41798N	-	-	-	figure legend:"2A (C)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:7.0x10^-9(molar)	2020/01/02	2020/01/14	rogid:6vjM8nCX9dFO2PtS54SfLqw0K0w9606	rogid:h/+2jen/dw+5leVis906F7iBs/A9606	rigid:a1z6jt//VsaBCniyMqO+SGWkdbk	false	sufficient binding region:29-212	sufficient binding region:33-725|his tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01580-PRO_0000016453	uniprotkb:Q99523	intact:EBI-25396641	intact:EBI-1057058|uniprotkb:Q8IZ49|uniprotkb:C0JYZ0|uniprotkb:B4DWI3|ensembl:ENSP00000256637	psi-mi:p01580-pro_0000016453(display_long)|uniprotkb:Ifng(gene name)|psi-mi:Ifng(display_short)	psi-mi:sort_human(display_long)|uniprotkb:SORT1(gene name)|psi-mi:SORT1(display_short)|uniprotkb:Neurotensin receptor 3(gene name synonym)|uniprotkb:Glycoprotein 95(gene name synonym)|uniprotkb:100 kDa NT receptor(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Mortensen et al. (2014)	pubmed:25401472|imex:IM-27639	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25396634|imex:IM-27639-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-7892102(chain-parent)	refseq:NP_001192157.1|refseq:NP_002950.3|ensembl:ENSG00000134243(gene)|ensembl:ENST00000256637(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0006895"(Golgi to endosome transport)|go:"GO:0006897"(endocytosis)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010465"(nerve growth factor receptor activity)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014902"(myotube differentiation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016050"(vesicle organization)|go:"GO:0019899"(enzyme binding)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030379"(neurotensin receptor activity, non-G protein-coupled)|go:"GO:0030425"(dendrite)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032509"(endosome transport via multivesicular body sorting pathway)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0046323"(glucose import)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048227"(plasma membrane to endosome transport)|go:"GO:0048406"(nerve growth factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051005"(negative regulation of lipoprotein lipase activity)|go:"GO:0090160"(Golgi to lysosome transport)|go:"GO:1904037"(positive regulation of epithelial cell apoptotic process)|go:"GO:1905394"(retromer complex binding)|interpro:IPR006581(VPS10)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR031777|interpro:IPR031778|mint:Q99523|rcsb pdb:3F6K|rcsb pdb:3G2U|rcsb pdb:3G2V|rcsb pdb:4MSL|rcsb pdb:4N7E|rcsb pdb:4PO7|rcsb pdb:5MRH|rcsb pdb:5MRI|rcsb pdb:6EHO|rcsb pdb:6X3L|rcsb pdb:6X48|rcsb pdb:6X4H|reactome:R-HSA-432722|go:"GO:0032868"(response to insulin)|dip:DIP-41798N	-	chain-seq-start:23|chain-seq-end:155	-	figure legend:2B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1.0x10^-9(molar)	2020/01/02	2020/01/14	rogid:GNjrUT1h2EwLUtsWSObBF9Mzzfc10090	rogid:h/+2jen/dw+5leVis906F7iBs/A9606	rigid:YlhfMhGL4gUpb3bKOa7kQMjpwd4	false	-	sufficient binding region:33-725|his tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q99523	uniprotkb:Q99523-PRO_0000033162	intact:EBI-1057058|uniprotkb:Q8IZ49|uniprotkb:C0JYZ0|uniprotkb:B4DWI3|ensembl:ENSP00000256637	intact:EBI-21474780	psi-mi:sort_human(display_long)|uniprotkb:SORT1(gene name)|psi-mi:SORT1(display_short)|uniprotkb:Neurotensin receptor 3(gene name synonym)|uniprotkb:Glycoprotein 95(gene name synonym)|uniprotkb:100 kDa NT receptor(gene name synonym)	psi-mi:q99523-pro_0000033162(display_long)|uniprotkb:SORT1(gene name)|psi-mi:SORT1(display_short)|uniprotkb:100 kDa NT receptor(gene name synonym)|uniprotkb:Glycoprotein 95(gene name synonym)|uniprotkb:Neurotensin receptor 3(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Mortensen et al. (2014)	pubmed:25401472|imex:IM-27639	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25396647|imex:IM-27639-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001192157.1|refseq:NP_002950.3|ensembl:ENSG00000134243(gene)|ensembl:ENST00000256637(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0006895"(Golgi to endosome transport)|go:"GO:0006897"(endocytosis)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010465"(nerve growth factor receptor activity)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014902"(myotube differentiation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016050"(vesicle organization)|go:"GO:0019899"(enzyme binding)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030379"(neurotensin receptor activity, non-G protein-coupled)|go:"GO:0030425"(dendrite)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032509"(endosome transport via multivesicular body sorting pathway)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0046323"(glucose import)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048227"(plasma membrane to endosome transport)|go:"GO:0048406"(nerve growth factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051005"(negative regulation of lipoprotein lipase activity)|go:"GO:0090160"(Golgi to lysosome transport)|go:"GO:1904037"(positive regulation of epithelial cell apoptotic process)|go:"GO:1905394"(retromer complex binding)|interpro:IPR006581(VPS10)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR031777|interpro:IPR031778|mint:Q99523|rcsb pdb:3F6K|rcsb pdb:3G2U|rcsb pdb:3G2V|rcsb pdb:4MSL|rcsb pdb:4N7E|rcsb pdb:4PO7|rcsb pdb:5MRH|rcsb pdb:5MRI|rcsb pdb:6EHO|rcsb pdb:6X3L|rcsb pdb:6X48|rcsb pdb:6X4H|reactome:R-HSA-432722|go:"GO:0032868"(response to insulin)|dip:DIP-41798N	intact:EBI-1057058(chain-parent)	-	-	chain-seq-start:34|chain-seq-end:77	figure legend:2C-2|comment:Binding of IL6 to sortilin was abolished by sortilin propeptide.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/01/02	2020/02/14	rogid:h/+2jen/dw+5leVis906F7iBs/A9606	rogid:roj1C3Ad8e8pA+G7IZ7LQeKF2I09606	rigid:u6aC/p4LIMND7ITJIepBSmOZNiM	false	sufficient binding region:33-725|his tag:c-c	glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q99523	uniprotkb:P05231	intact:EBI-1057058|uniprotkb:Q8IZ49|uniprotkb:C0JYZ0|uniprotkb:B4DWI3|ensembl:ENSP00000256637	intact:EBI-720533|uniprotkb:Q9UCU4|uniprotkb:Q9UCU2|uniprotkb:Q9UCU3|ensembl:ENSP00000258743|ensembl:ENSP00000385675	psi-mi:sort_human(display_long)|uniprotkb:SORT1(gene name)|psi-mi:SORT1(display_short)|uniprotkb:Neurotensin receptor 3(gene name synonym)|uniprotkb:Glycoprotein 95(gene name synonym)|uniprotkb:100 kDa NT receptor(gene name synonym)	psi-mi:il6_human(display_long)|uniprotkb:B-cell stimulatory factor 2(gene name synonym)|uniprotkb:Interferon beta-2(gene name synonym)|uniprotkb:Hybridoma growth factor(gene name synonym)|uniprotkb:CTL differentiation factor(gene name synonym)|uniprotkb:IL6(gene name)|psi-mi:IL6(display_short)|uniprotkb:IFNB2(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Mortensen et al. (2014)	pubmed:25401472|imex:IM-27639	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25396647|imex:IM-27639-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001192157.1|refseq:NP_002950.3|ensembl:ENSG00000134243(gene)|ensembl:ENST00000256637(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0006895"(Golgi to endosome transport)|go:"GO:0006897"(endocytosis)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010465"(nerve growth factor receptor activity)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014902"(myotube differentiation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016050"(vesicle organization)|go:"GO:0019899"(enzyme binding)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030379"(neurotensin receptor activity, non-G protein-coupled)|go:"GO:0030425"(dendrite)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032509"(endosome transport via multivesicular body sorting pathway)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0046323"(glucose import)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048227"(plasma membrane to endosome transport)|go:"GO:0048406"(nerve growth factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051005"(negative regulation of lipoprotein lipase activity)|go:"GO:0090160"(Golgi to lysosome transport)|go:"GO:1904037"(positive regulation of epithelial cell apoptotic process)|go:"GO:1905394"(retromer complex binding)|interpro:IPR006581(VPS10)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR031777|interpro:IPR031778|mint:Q99523|rcsb pdb:3F6K|rcsb pdb:3G2U|rcsb pdb:3G2V|rcsb pdb:4MSL|rcsb pdb:4N7E|rcsb pdb:4PO7|rcsb pdb:5MRH|rcsb pdb:5MRI|rcsb pdb:6EHO|rcsb pdb:6X3L|rcsb pdb:6X48|rcsb pdb:6X4H|reactome:R-HSA-432722|go:"GO:0032868"(response to insulin)|dip:DIP-41798N	go:"GO:0001781"(neutrophil apoptotic process)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0050871"(positive regulation of B cell activation)|refseq:NP_000591.1|refseq:XP_011513692.1|dip:DIP-482N|ensembl:ENSG00000136244(gene)|ensembl:ENST00000258743(transcript)|ensembl:ENST00000404625(transcript)|go:"GO:0002384"(hepatic immune response)|go:"GO:0002446"(neutrophil mediated immunity)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0002675"(positive regulation of acute inflammatory response)|go:"GO:0002690"(positive regulation of leukocyte chemotaxis)|go:"GO:0005125"(cytokine activity)|go:"GO:0005138"(interleukin-6 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005896"(interleukin-6 receptor complex)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0002314"(germinal center B cell differentiation)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010574"(regulation of vascular endothelial growth factor production)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0014823"(response to activity)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030168"(platelet activation)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0031175"(neuron projection development)|go:"GO:0032494"(response to peptidoglycan)|go:"GO:0032682"(negative regulation of chemokine production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032745"(positive regulation of interleukin-21 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032966"(negative regulation of collagen biosynthetic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051607"(defense response to virus)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0061470"(T follicular helper cell differentiation)|go:"GO:0061888"(regulation of astrocyte activation)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070091"(glucagon secretion)|go:"GO:0070092"(regulation of glucagon secretion)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0072574"(hepatocyte proliferation)|go:"GO:0090091"(positive regulation of extracellular matrix disassembly)|go:"GO:0097421"(liver regeneration)|go:"GO:0098586"(cellular response to virus)|go:"GO:0150077"(regulation of neuroinflammatory response)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901731"(positive regulation of platelet aggregation)|go:"GO:1902512"(positive regulation of apoptotic DNA fragmentation)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903978"(regulation of microglial cell activation)|go:"GO:1904894"(positive regulation of receptor signaling pathway via STAT)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000660"(negative regulation of interleukin-1-mediated signaling pathway)|go:"GO:2000676"(positive regulation of type B pancreatic cell apoptotic process)|interpro:IPR003574(Interleukin-6)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR030473|interpro:IPR030474|rcsb pdb:1ALU|rcsb pdb:1IL6|rcsb pdb:1N2Q|rcsb pdb:1P9M|rcsb pdb:2IL6|rcsb pdb:4CNI|rcsb pdb:4J4L|rcsb pdb:4NI7|rcsb pdb:4NI9|rcsb pdb:4O9H|rcsb pdb:4ZS7|rcsb pdb:5FUC|rcsb pdb:7NXZ|reactome:R-HSA-1059683|reactome:R-HSA-110056|reactome:R-HSA-112411|reactome:R-HSA-2559582|reactome:R-HSA-381426|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8853884|reactome:R-HSA-8957275|reactome:R-HSA-9660821|reactome:R-HSA-9662834	-	-	-	figure legend:2C-2|comment:Binding of IL6 to sortilin was abolished by sortilin propeptide.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/01/02	2020/02/14	rogid:h/+2jen/dw+5leVis906F7iBs/A9606	rogid:6vjM8nCX9dFO2PtS54SfLqw0K0w9606	rigid:u6aC/p4LIMND7ITJIepBSmOZNiM	false	sufficient binding region:33-725|his tag:c-c	sufficient binding region:29-212	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q99523-PRO_0000033162	uniprotkb:Q99523	intact:EBI-21474780	intact:EBI-1057058|uniprotkb:Q8IZ49|uniprotkb:C0JYZ0|uniprotkb:B4DWI3|ensembl:ENSP00000256637	psi-mi:q99523-pro_0000033162(display_long)|uniprotkb:SORT1(gene name)|psi-mi:SORT1(display_short)|uniprotkb:100 kDa NT receptor(gene name synonym)|uniprotkb:Glycoprotein 95(gene name synonym)|uniprotkb:Neurotensin receptor 3(gene name synonym)	psi-mi:sort_human(display_long)|uniprotkb:SORT1(gene name)|psi-mi:SORT1(display_short)|uniprotkb:Neurotensin receptor 3(gene name synonym)|uniprotkb:Glycoprotein 95(gene name synonym)|uniprotkb:100 kDa NT receptor(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Mortensen et al. (2014)	pubmed:25401472|imex:IM-27639	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25396654|imex:IM-27639-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1057058(chain-parent)	refseq:NP_001192157.1|refseq:NP_002950.3|ensembl:ENSG00000134243(gene)|ensembl:ENST00000256637(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0006895"(Golgi to endosome transport)|go:"GO:0006897"(endocytosis)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010465"(nerve growth factor receptor activity)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014902"(myotube differentiation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016050"(vesicle organization)|go:"GO:0019899"(enzyme binding)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030379"(neurotensin receptor activity, non-G protein-coupled)|go:"GO:0030425"(dendrite)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032509"(endosome transport via multivesicular body sorting pathway)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0046323"(glucose import)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048227"(plasma membrane to endosome transport)|go:"GO:0048406"(nerve growth factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051005"(negative regulation of lipoprotein lipase activity)|go:"GO:0090160"(Golgi to lysosome transport)|go:"GO:1904037"(positive regulation of epithelial cell apoptotic process)|go:"GO:1905394"(retromer complex binding)|interpro:IPR006581(VPS10)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR031777|interpro:IPR031778|mint:Q99523|rcsb pdb:3F6K|rcsb pdb:3G2U|rcsb pdb:3G2V|rcsb pdb:4MSL|rcsb pdb:4N7E|rcsb pdb:4PO7|rcsb pdb:5MRH|rcsb pdb:5MRI|rcsb pdb:6EHO|rcsb pdb:6X3L|rcsb pdb:6X48|rcsb pdb:6X4H|reactome:R-HSA-432722|go:"GO:0032868"(response to insulin)|dip:DIP-41798N	-	chain-seq-start:34|chain-seq-end:77	-	figure legend:2C-1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/01/02	2020/01/14	rogid:roj1C3Ad8e8pA+G7IZ7LQeKF2I09606	rogid:h/+2jen/dw+5leVis906F7iBs/A9606	rigid:R2ODHfFn4vHy9sM2YFAC9mfWRHQ	false	glutathione s tranferase tag:n-n	sufficient binding region:33-725|his tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P05231	uniprotkb:Q99523	intact:EBI-720533|uniprotkb:Q9UCU4|uniprotkb:Q9UCU2|uniprotkb:Q9UCU3|ensembl:ENSP00000258743|ensembl:ENSP00000385675	intact:EBI-1057058|uniprotkb:Q8IZ49|uniprotkb:C0JYZ0|uniprotkb:B4DWI3|ensembl:ENSP00000256637	psi-mi:il6_human(display_long)|uniprotkb:B-cell stimulatory factor 2(gene name synonym)|uniprotkb:Interferon beta-2(gene name synonym)|uniprotkb:Hybridoma growth factor(gene name synonym)|uniprotkb:CTL differentiation factor(gene name synonym)|uniprotkb:IL6(gene name)|psi-mi:IL6(display_short)|uniprotkb:IFNB2(gene name synonym)	psi-mi:sort_human(display_long)|uniprotkb:SORT1(gene name)|psi-mi:SORT1(display_short)|uniprotkb:Neurotensin receptor 3(gene name synonym)|uniprotkb:Glycoprotein 95(gene name synonym)|uniprotkb:100 kDa NT receptor(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Mortensen et al. (2014)	pubmed:25401472|imex:IM-27639	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25396666|imex:IM-27639-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0001781"(neutrophil apoptotic process)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0050871"(positive regulation of B cell activation)|refseq:NP_000591.1|refseq:XP_011513692.1|dip:DIP-482N|ensembl:ENSG00000136244(gene)|ensembl:ENST00000258743(transcript)|ensembl:ENST00000404625(transcript)|go:"GO:0002384"(hepatic immune response)|go:"GO:0002446"(neutrophil mediated immunity)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0002675"(positive regulation of acute inflammatory response)|go:"GO:0002690"(positive regulation of leukocyte chemotaxis)|go:"GO:0005125"(cytokine activity)|go:"GO:0005138"(interleukin-6 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005896"(interleukin-6 receptor complex)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0002314"(germinal center B cell differentiation)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010574"(regulation of vascular endothelial growth factor production)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0014823"(response to activity)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030168"(platelet activation)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0031175"(neuron projection development)|go:"GO:0032494"(response to peptidoglycan)|go:"GO:0032682"(negative regulation of chemokine production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032745"(positive regulation of interleukin-21 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032966"(negative regulation of collagen biosynthetic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051607"(defense response to virus)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0061470"(T follicular helper cell differentiation)|go:"GO:0061888"(regulation of astrocyte activation)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070091"(glucagon secretion)|go:"GO:0070092"(regulation of glucagon secretion)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0072574"(hepatocyte proliferation)|go:"GO:0090091"(positive regulation of extracellular matrix disassembly)|go:"GO:0097421"(liver regeneration)|go:"GO:0098586"(cellular response to virus)|go:"GO:0150077"(regulation of neuroinflammatory response)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901731"(positive regulation of platelet aggregation)|go:"GO:1902512"(positive regulation of apoptotic DNA fragmentation)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903978"(regulation of microglial cell activation)|go:"GO:1904894"(positive regulation of receptor signaling pathway via STAT)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000660"(negative regulation of interleukin-1-mediated signaling pathway)|go:"GO:2000676"(positive regulation of type B pancreatic cell apoptotic process)|interpro:IPR003574(Interleukin-6)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR030473|interpro:IPR030474|rcsb pdb:1ALU|rcsb pdb:1IL6|rcsb pdb:1N2Q|rcsb pdb:1P9M|rcsb pdb:2IL6|rcsb pdb:4CNI|rcsb pdb:4J4L|rcsb pdb:4NI7|rcsb pdb:4NI9|rcsb pdb:4O9H|rcsb pdb:4ZS7|rcsb pdb:5FUC|rcsb pdb:7NXZ|reactome:R-HSA-1059683|reactome:R-HSA-110056|reactome:R-HSA-112411|reactome:R-HSA-2559582|reactome:R-HSA-381426|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8853884|reactome:R-HSA-8957275|reactome:R-HSA-9660821|reactome:R-HSA-9662834	refseq:NP_001192157.1|refseq:NP_002950.3|ensembl:ENSG00000134243(gene)|ensembl:ENST00000256637(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0006895"(Golgi to endosome transport)|go:"GO:0006897"(endocytosis)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010465"(nerve growth factor receptor activity)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014902"(myotube differentiation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016050"(vesicle organization)|go:"GO:0019899"(enzyme binding)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030379"(neurotensin receptor activity, non-G protein-coupled)|go:"GO:0030425"(dendrite)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032509"(endosome transport via multivesicular body sorting pathway)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0046323"(glucose import)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048227"(plasma membrane to endosome transport)|go:"GO:0048406"(nerve growth factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051005"(negative regulation of lipoprotein lipase activity)|go:"GO:0090160"(Golgi to lysosome transport)|go:"GO:1904037"(positive regulation of epithelial cell apoptotic process)|go:"GO:1905394"(retromer complex binding)|interpro:IPR006581(VPS10)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR031777|interpro:IPR031778|mint:Q99523|rcsb pdb:3F6K|rcsb pdb:3G2U|rcsb pdb:3G2V|rcsb pdb:4MSL|rcsb pdb:4N7E|rcsb pdb:4PO7|rcsb pdb:5MRH|rcsb pdb:5MRI|rcsb pdb:6EHO|rcsb pdb:6X3L|rcsb pdb:6X48|rcsb pdb:6X4H|reactome:R-HSA-432722|go:"GO:0032868"(response to insulin)|dip:DIP-41798N	go:"GO:0005886"(plasma membrane)	-	-	figure legend:2D|antagonist:Sortilin pro-peptide -PRO_0000033162.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/01/02	2020/01/14	rogid:6vjM8nCX9dFO2PtS54SfLqw0K0w9606	rogid:h/+2jen/dw+5leVis906F7iBs/A9606	rigid:a1z6jt//VsaBCniyMqO+SGWkdbk	false	sufficient binding region:29-212	-	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)
uniprotkb:P05231	uniprotkb:Q99523	intact:EBI-720533|uniprotkb:Q9UCU4|uniprotkb:Q9UCU2|uniprotkb:Q9UCU3|ensembl:ENSP00000258743|ensembl:ENSP00000385675	intact:EBI-1057058|uniprotkb:Q8IZ49|uniprotkb:C0JYZ0|uniprotkb:B4DWI3|ensembl:ENSP00000256637	psi-mi:il6_human(display_long)|uniprotkb:B-cell stimulatory factor 2(gene name synonym)|uniprotkb:Interferon beta-2(gene name synonym)|uniprotkb:Hybridoma growth factor(gene name synonym)|uniprotkb:CTL differentiation factor(gene name synonym)|uniprotkb:IL6(gene name)|psi-mi:IL6(display_short)|uniprotkb:IFNB2(gene name synonym)	psi-mi:sort_human(display_long)|uniprotkb:SORT1(gene name)|psi-mi:SORT1(display_short)|uniprotkb:Neurotensin receptor 3(gene name synonym)|uniprotkb:Glycoprotein 95(gene name synonym)|uniprotkb:100 kDa NT receptor(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Mortensen et al. (2014)	pubmed:25401472|imex:IM-27639	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25396692|imex:IM-27639-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0001781"(neutrophil apoptotic process)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0050871"(positive regulation of B cell activation)|refseq:NP_000591.1|refseq:XP_011513692.1|dip:DIP-482N|ensembl:ENSG00000136244(gene)|ensembl:ENST00000258743(transcript)|ensembl:ENST00000404625(transcript)|go:"GO:0002384"(hepatic immune response)|go:"GO:0002446"(neutrophil mediated immunity)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0002675"(positive regulation of acute inflammatory response)|go:"GO:0002690"(positive regulation of leukocyte chemotaxis)|go:"GO:0005125"(cytokine activity)|go:"GO:0005138"(interleukin-6 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005896"(interleukin-6 receptor complex)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0002314"(germinal center B cell differentiation)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010574"(regulation of vascular endothelial growth factor production)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0014823"(response to activity)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030168"(platelet activation)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0031175"(neuron projection development)|go:"GO:0032494"(response to peptidoglycan)|go:"GO:0032682"(negative regulation of chemokine production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032745"(positive regulation of interleukin-21 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032966"(negative regulation of collagen biosynthetic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051607"(defense response to virus)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0061470"(T follicular helper cell differentiation)|go:"GO:0061888"(regulation of astrocyte activation)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070091"(glucagon secretion)|go:"GO:0070092"(regulation of glucagon secretion)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0072574"(hepatocyte proliferation)|go:"GO:0090091"(positive regulation of extracellular matrix disassembly)|go:"GO:0097421"(liver regeneration)|go:"GO:0098586"(cellular response to virus)|go:"GO:0150077"(regulation of neuroinflammatory response)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901731"(positive regulation of platelet aggregation)|go:"GO:1902512"(positive regulation of apoptotic DNA fragmentation)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903978"(regulation of microglial cell activation)|go:"GO:1904894"(positive regulation of receptor signaling pathway via STAT)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000660"(negative regulation of interleukin-1-mediated signaling pathway)|go:"GO:2000676"(positive regulation of type B pancreatic cell apoptotic process)|interpro:IPR003574(Interleukin-6)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR030473|interpro:IPR030474|rcsb pdb:1ALU|rcsb pdb:1IL6|rcsb pdb:1N2Q|rcsb pdb:1P9M|rcsb pdb:2IL6|rcsb pdb:4CNI|rcsb pdb:4J4L|rcsb pdb:4NI7|rcsb pdb:4NI9|rcsb pdb:4O9H|rcsb pdb:4ZS7|rcsb pdb:5FUC|rcsb pdb:7NXZ|reactome:R-HSA-1059683|reactome:R-HSA-110056|reactome:R-HSA-112411|reactome:R-HSA-2559582|reactome:R-HSA-381426|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8853884|reactome:R-HSA-8957275|reactome:R-HSA-9660821|reactome:R-HSA-9662834	refseq:NP_001192157.1|refseq:NP_002950.3|ensembl:ENSG00000134243(gene)|ensembl:ENST00000256637(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0006895"(Golgi to endosome transport)|go:"GO:0006897"(endocytosis)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010465"(nerve growth factor receptor activity)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014902"(myotube differentiation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016050"(vesicle organization)|go:"GO:0019899"(enzyme binding)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030379"(neurotensin receptor activity, non-G protein-coupled)|go:"GO:0030425"(dendrite)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032509"(endosome transport via multivesicular body sorting pathway)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0046323"(glucose import)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048227"(plasma membrane to endosome transport)|go:"GO:0048406"(nerve growth factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051005"(negative regulation of lipoprotein lipase activity)|go:"GO:0090160"(Golgi to lysosome transport)|go:"GO:1904037"(positive regulation of epithelial cell apoptotic process)|go:"GO:1905394"(retromer complex binding)|interpro:IPR006581(VPS10)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR031777|interpro:IPR031778|mint:Q99523|rcsb pdb:3F6K|rcsb pdb:3G2U|rcsb pdb:3G2V|rcsb pdb:4MSL|rcsb pdb:4N7E|rcsb pdb:4PO7|rcsb pdb:5MRH|rcsb pdb:5MRI|rcsb pdb:6EHO|rcsb pdb:6X3L|rcsb pdb:6X48|rcsb pdb:6X4H|reactome:R-HSA-432722|go:"GO:0032868"(response to insulin)|dip:DIP-41798N	-	-	-	figure legend:2F|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2020/01/02	2020/01/14	rogid:6vjM8nCX9dFO2PtS54SfLqw0K0w9606	rogid:h/+2jen/dw+5leVis906F7iBs/A9606	rigid:a1z6jt//VsaBCniyMqO+SGWkdbk	false	green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)