#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
chebi:"CHEBI:28808"	uniprotkb:P11226	intact:EBI-25613000|chebi:"CHEBI:6684"|chebi:"CHEBI:25159"	intact:EBI-5325353|ensembl:ENSP00000363079|ensembl:ENSP00000502615|ensembl:ENSP00000502789|uniprotkb:Q4VB12|uniprotkb:Q4VB13|uniprotkb:Q86SI4|uniprotkb:Q96KE4|uniprotkb:Q96TF7|uniprotkb:Q96TF8|uniprotkb:Q96TF9|uniprotkb:Q4VB14|uniprotkb:Q5SQS3	psi-mi:mannan(display_short)|psi-mi:"CHEBI:28808"(display_long)|intact:Mannan(synonym)|intact:mannans(synonym)|intact:Mannoglycan(synonym)|intact:mannan(iupac name)	psi-mi:mbl2_human(display_long)|uniprotkb:MBL2(gene name)|psi-mi:MBL2(display_short)|uniprotkb:COLEC1(gene name synonym)|uniprotkb:MBL(gene name synonym)|uniprotkb:Collectin-1(gene name synonym)|uniprotkb:MBP1(gene name synonym)|uniprotkb:Mannan-binding protein(gene name synonym)|uniprotkb:Mannose-binding lectin(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Keizer et al. (2015)	pubmed:25359215|imex:IM-29223	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27087845|imex:IM-29223-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000165471(gene)|ensembl:ENST00000373968(transcript)|ensembl:ENST00000674931(transcript)|ensembl:ENST00000675947(transcript)|go:"GO:0001867"(complement activation, lectin pathway)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005537"(mannose binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0006953"(acute-phase response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008228"(opsonization)|go:"GO:0009986"(cell surface)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048525"(negative regulation of viral process)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR001304(C-type lectin)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR016186(C-type lectin-like)|refseq:XP_011538118.1|interpro:IPR018378|interpro:IPR033990|interpro:IPR037570|rcsb pdb:1HUP|interpro:IPR016187(C-type lectin fold)|reactome:R-HSA-166662|reactome:R-HSA-166663|refseq:NP_000233.1|refseq:XP_006717924.1|dip:DIP-61381N	-	-	-	figure legend:1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/17	2021/09/16	-	rogid:uo0RM88uw3otObIVnOhUcOfW8yo9606	-	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:180472"	uniprotkb:O00187	intact:EBI-27087858	intact:EBI-7965040|uniprotkb:Q9UMV3|intact:MINT-7970114|uniprotkb:Q9ULC7|uniprotkb:Q9Y270|uniprotkb:A8MWJ2|uniprotkb:O75754|uniprotkb:Q96QG4|uniprotkb:Q9UBP3|uniprotkb:Q5TEQ5|uniprotkb:Q5TER0|uniprotkb:Q9H498|uniprotkb:Q9UC48|uniprotkb:A8K458|uniprotkb:Q9H499|uniprotkb:Q9BZH0|ensembl:ENSP00000383690	psi-mi:z-l-lys-sbzl hydrochloride(display_short)|psi-mi:"CHEBI:180472"(display_long)	psi-mi:masp2_human(display_long)|uniprotkb:MASP2(gene name)|psi-mi:MASP2(display_short)|uniprotkb:Mannose-binding protein-associated serine protease 2(gene name synonym)|uniprotkb:MBL-associated serine protease 2(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Keizer et al. (2015)	pubmed:25359215|imex:IM-29223	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27087856|imex:IM-29223-3	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_631947.1|refseq:NP_006601.2|ensembl:ENSG00000009724(gene)|ensembl:ENST00000400897(transcript)|go:"GO:0001855"(complement component C4b binding)|go:"GO:0001867"(complement activation, lectin pathway)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0008233"(peptidase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000859(CUB)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR018097|interpro:IPR033116|interpro:IPR035914|interpro:IPR035976|interpro:IPR037571|interpro:IPR043504|rcsb pdb:1Q3X|rcsb pdb:1SZB|rcsb pdb:1ZJK|rcsb pdb:3TVJ|rcsb pdb:4FXG|rcsb pdb:5JPM|reactome:R-HSA-166662|reactome:R-HSA-166663|reactome:R-HSA-2855086	-	-	comment:mint	figure legend:2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/17	2021/09/16	-	rogid:S48IDwjdZ8M6vIJD6iM0XplSN609606	-	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O00187	uniprotkb:P10646	intact:EBI-7965040|uniprotkb:Q9UMV3|intact:MINT-7970114|uniprotkb:Q9ULC7|uniprotkb:Q9Y270|uniprotkb:A8MWJ2|uniprotkb:O75754|uniprotkb:Q96QG4|uniprotkb:Q9UBP3|uniprotkb:Q5TEQ5|uniprotkb:Q5TER0|uniprotkb:Q9H498|uniprotkb:Q9UC48|uniprotkb:A8K458|uniprotkb:Q9H499|uniprotkb:Q9BZH0|ensembl:ENSP00000383690	intact:EBI-5458302|uniprotkb:O95103|uniprotkb:Q53TS4|ensembl:ENSP00000233156|ensembl:ENSP00000376172	psi-mi:masp2_human(display_long)|uniprotkb:MASP2(gene name)|psi-mi:MASP2(display_short)|uniprotkb:Mannose-binding protein-associated serine protease 2(gene name synonym)|uniprotkb:MBL-associated serine protease 2(gene name synonym)	psi-mi:tfpi1_human(display_long)|uniprotkb:TFPI(gene name)|psi-mi:TFPI(display_short)|uniprotkb:LACI(gene name synonym)|uniprotkb:TFPI1(gene name synonym)|uniprotkb:Extrinsic pathway inhibitor(gene name synonym)|uniprotkb:Lipoprotein-associated coagulation inhibitor(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Keizer et al. (2015)	pubmed:25359215|imex:IM-29223	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27087916|imex:IM-29223-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_631947.1|refseq:NP_006601.2|ensembl:ENSG00000009724(gene)|ensembl:ENST00000400897(transcript)|go:"GO:0001855"(complement component C4b binding)|go:"GO:0001867"(complement activation, lectin pathway)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0008233"(peptidase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000859(CUB)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR018097|interpro:IPR033116|interpro:IPR035914|interpro:IPR035976|interpro:IPR037571|interpro:IPR043504|rcsb pdb:1Q3X|rcsb pdb:1SZB|rcsb pdb:1ZJK|rcsb pdb:3TVJ|rcsb pdb:4FXG|rcsb pdb:5JPM|reactome:R-HSA-166662|reactome:R-HSA-166663|reactome:R-HSA-2855086	refseq:XP_011510011.1|refseq:NP_001305870.1|refseq:NP_001027452.1|refseq:NP_006278.1|refseq:XP_005246876.1|refseq:XP_006712783.1|refseq:NP_001316168.1|refseq:NP_001316169.1|refseq:NP_001316170.1|ensembl:ENSG00000003436(gene)|ensembl:ENST00000233156(transcript)|ensembl:ENST00000392365(transcript)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0007596"(blood coagulation)|go:"GO:0009986"(cell surface)|go:"GO:0030195"(negative regulation of blood coagulation)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0032355"(response to estradiol)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071383"(cellular response to steroid hormone stimulus)|interpro:IPR002223(Proteinase inhibitor I2, Kunitz metazoa)|interpro:IPR008296(Proteinase inhibitor I2, tissue factor pathway inhibitor)|interpro:IPR020901|interpro:IPR036880|rcsb pdb:1ADZ|rcsb pdb:1IRH|rcsb pdb:1TFX|rcsb pdb:4BQD|rcsb pdb:4DTG|rcsb pdb:5NMV|rcsb pdb:6BX8|reactome:R-HSA-140834	-	comment:mint	-	figure legend:2A, 3|comment:"The Kunitz-2 domain (possibly aas 125-175) is the primary domain of TFPI involved in MASP-2 inhibition, as shown by the use of antibodies to various regions of TFPI."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/17	2021/09/16	rogid:S48IDwjdZ8M6vIJD6iM0XplSN609606	rogid:ht+foTagAsRCPXND2I7g3ILSWUo9606	-	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:180472"	uniprotkb:O00187	intact:EBI-27087858	intact:EBI-7965040|uniprotkb:Q9UMV3|intact:MINT-7970114|uniprotkb:Q9ULC7|uniprotkb:Q9Y270|uniprotkb:A8MWJ2|uniprotkb:O75754|uniprotkb:Q96QG4|uniprotkb:Q9UBP3|uniprotkb:Q5TEQ5|uniprotkb:Q5TER0|uniprotkb:Q9H498|uniprotkb:Q9UC48|uniprotkb:A8K458|uniprotkb:Q9H499|uniprotkb:Q9BZH0|ensembl:ENSP00000383690	psi-mi:z-l-lys-sbzl hydrochloride(display_short)|psi-mi:"CHEBI:180472"(display_long)	psi-mi:masp2_human(display_long)|uniprotkb:MASP2(gene name)|psi-mi:MASP2(display_short)|uniprotkb:Mannose-binding protein-associated serine protease 2(gene name synonym)|uniprotkb:MBL-associated serine protease 2(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Keizer et al. (2015)	pubmed:25359215|imex:IM-29223	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27087916|imex:IM-29223-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_631947.1|refseq:NP_006601.2|ensembl:ENSG00000009724(gene)|ensembl:ENST00000400897(transcript)|go:"GO:0001855"(complement component C4b binding)|go:"GO:0001867"(complement activation, lectin pathway)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0008233"(peptidase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000859(CUB)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR018097|interpro:IPR033116|interpro:IPR035914|interpro:IPR035976|interpro:IPR037571|interpro:IPR043504|rcsb pdb:1Q3X|rcsb pdb:1SZB|rcsb pdb:1ZJK|rcsb pdb:3TVJ|rcsb pdb:4FXG|rcsb pdb:5JPM|reactome:R-HSA-166662|reactome:R-HSA-166663|reactome:R-HSA-2855086	-	-	comment:mint	figure legend:2A, 3|comment:"The Kunitz-2 domain (possibly aas 125-175) is the primary domain of TFPI involved in MASP-2 inhibition, as shown by the use of antibodies to various regions of TFPI."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/17	2021/09/16	-	rogid:S48IDwjdZ8M6vIJD6iM0XplSN609606	-	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P05155	uniprotkb:O00187	intact:EBI-1223454|uniprotkb:Q547W3|uniprotkb:Q59EI5|uniprotkb:Q96FE0|uniprotkb:A6NMU0|uniprotkb:A8KAI9|uniprotkb:B2R6L5|uniprotkb:Q16304|uniprotkb:Q7Z455|uniprotkb:Q9UC49|uniprotkb:Q9UCF9|uniprotkb:B4E1F0|uniprotkb:B4E1H2|ensembl:ENSP00000278407|ensembl:ENSP00000504807	intact:EBI-7965040|uniprotkb:Q9UMV3|intact:MINT-7970114|uniprotkb:Q9ULC7|uniprotkb:Q9Y270|uniprotkb:A8MWJ2|uniprotkb:O75754|uniprotkb:Q96QG4|uniprotkb:Q9UBP3|uniprotkb:Q5TEQ5|uniprotkb:Q5TER0|uniprotkb:Q9H498|uniprotkb:Q9UC48|uniprotkb:A8K458|uniprotkb:Q9H499|uniprotkb:Q9BZH0|ensembl:ENSP00000383690	psi-mi:ic1_human(display_long)|uniprotkb:SERPING1(gene name)|psi-mi:SERPING1(display_short)|uniprotkb:C1IN(gene name synonym)|uniprotkb:C1NH(gene name synonym)|uniprotkb:C1 esterase inhibitor(gene name synonym)|uniprotkb:C1-inhibiting factor(gene name synonym)|uniprotkb:Serpin G1(gene name synonym)	psi-mi:masp2_human(display_long)|uniprotkb:MASP2(gene name)|psi-mi:MASP2(display_short)|uniprotkb:Mannose-binding protein-associated serine protease 2(gene name synonym)|uniprotkb:MBL-associated serine protease 2(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Keizer et al. (2015)	pubmed:25359215|imex:IM-29223	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27087923|imex:IM-29223-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000053.2|refseq:NP_001027466.1|dip:DIP-45635N|ensembl:ENSG00000149131(gene)|ensembl:ENST00000278407(transcript)|ensembl:ENST00000676670(transcript)|go:"GO:0001869"(negative regulation of complement activation, lectin pathway)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0007568"(aging)|go:"GO:0007596"(blood coagulation)|go:"GO:0008015"(blood circulation)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0042730"(fibrinolysis)|go:"GO:0045087"(innate immune response)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR015553(Protease inhibitor I4, serpin C1)|interpro:IPR023795|interpro:IPR023796|interpro:IPR036186|interpro:IPR042178|interpro:IPR042185|mint:P05155|rcsb pdb:1M6Q|rcsb pdb:2OAY|rcsb pdb:5DU3|rcsb pdb:5DUQ|rcsb pdb:7AKV|reactome:R-HSA-114608|reactome:R-HSA-140837|reactome:R-HSA-9657689|reactome:R-HSA-977606	refseq:NP_631947.1|refseq:NP_006601.2|ensembl:ENSG00000009724(gene)|ensembl:ENST00000400897(transcript)|go:"GO:0001855"(complement component C4b binding)|go:"GO:0001867"(complement activation, lectin pathway)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0008233"(peptidase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000859(CUB)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR018097|interpro:IPR033116|interpro:IPR035914|interpro:IPR035976|interpro:IPR037571|interpro:IPR043504|rcsb pdb:1Q3X|rcsb pdb:1SZB|rcsb pdb:1ZJK|rcsb pdb:3TVJ|rcsb pdb:4FXG|rcsb pdb:5JPM|reactome:R-HSA-166662|reactome:R-HSA-166663|reactome:R-HSA-2855086	-	-	comment:mint	figure legend:2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/17	2021/09/16	rogid:Y7cqCZ6Ryz51dsi6jM86EXdfeWc9606	rogid:S48IDwjdZ8M6vIJD6iM0XplSN609606	-	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:180472"	uniprotkb:P05155	intact:EBI-27087858	intact:EBI-1223454|uniprotkb:Q547W3|uniprotkb:Q59EI5|uniprotkb:Q96FE0|uniprotkb:A6NMU0|uniprotkb:A8KAI9|uniprotkb:B2R6L5|uniprotkb:Q16304|uniprotkb:Q7Z455|uniprotkb:Q9UC49|uniprotkb:Q9UCF9|uniprotkb:B4E1F0|uniprotkb:B4E1H2|ensembl:ENSP00000278407|ensembl:ENSP00000504807	psi-mi:z-l-lys-sbzl hydrochloride(display_short)|psi-mi:"CHEBI:180472"(display_long)	psi-mi:ic1_human(display_long)|uniprotkb:SERPING1(gene name)|psi-mi:SERPING1(display_short)|uniprotkb:C1IN(gene name synonym)|uniprotkb:C1NH(gene name synonym)|uniprotkb:C1 esterase inhibitor(gene name synonym)|uniprotkb:C1-inhibiting factor(gene name synonym)|uniprotkb:Serpin G1(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Keizer et al. (2015)	pubmed:25359215|imex:IM-29223	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27087923|imex:IM-29223-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000053.2|refseq:NP_001027466.1|dip:DIP-45635N|ensembl:ENSG00000149131(gene)|ensembl:ENST00000278407(transcript)|ensembl:ENST00000676670(transcript)|go:"GO:0001869"(negative regulation of complement activation, lectin pathway)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0007568"(aging)|go:"GO:0007596"(blood coagulation)|go:"GO:0008015"(blood circulation)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0042730"(fibrinolysis)|go:"GO:0045087"(innate immune response)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR015553(Protease inhibitor I4, serpin C1)|interpro:IPR023795|interpro:IPR023796|interpro:IPR036186|interpro:IPR042178|interpro:IPR042185|mint:P05155|rcsb pdb:1M6Q|rcsb pdb:2OAY|rcsb pdb:5DU3|rcsb pdb:5DUQ|rcsb pdb:7AKV|reactome:R-HSA-114608|reactome:R-HSA-140837|reactome:R-HSA-9657689|reactome:R-HSA-977606	-	-	-	figure legend:2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/17	2021/09/16	-	rogid:Y7cqCZ6Ryz51dsi6jM86EXdfeWc9606	-	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P09871	uniprotkb:P05155	intact:EBI-2810045|uniprotkb:Q9UCU9|uniprotkb:Q9UCV3|uniprotkb:Q9UCU7|uniprotkb:Q9UCV5|uniprotkb:Q9UCV4|uniprotkb:Q9UCU8|uniprotkb:Q9UCV2|uniprotkb:Q9UCV1|uniprotkb:Q9UCV0|uniprotkb:Q9UM14|uniprotkb:D3DUT4|ensembl:ENSP00000328173|ensembl:ENSP00000354057|ensembl:ENSP00000385035	intact:EBI-1223454|uniprotkb:Q547W3|uniprotkb:Q59EI5|uniprotkb:Q96FE0|uniprotkb:A6NMU0|uniprotkb:A8KAI9|uniprotkb:B2R6L5|uniprotkb:Q16304|uniprotkb:Q7Z455|uniprotkb:Q9UC49|uniprotkb:Q9UCF9|uniprotkb:B4E1F0|uniprotkb:B4E1H2|ensembl:ENSP00000278407|ensembl:ENSP00000504807	psi-mi:c1s_human(display_long)|uniprotkb:C1S(gene name)|psi-mi:C1S(display_short)|uniprotkb:C1 esterase(gene name synonym)|uniprotkb:Complement component 1 subcomponent s(gene name synonym)	psi-mi:ic1_human(display_long)|uniprotkb:SERPING1(gene name)|psi-mi:SERPING1(display_short)|uniprotkb:C1IN(gene name synonym)|uniprotkb:C1NH(gene name synonym)|uniprotkb:C1 esterase inhibitor(gene name synonym)|uniprotkb:C1-inhibiting factor(gene name synonym)|uniprotkb:Serpin G1(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Keizer et al. (2015)	pubmed:25359215|imex:IM-29223	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27087929|imex:IM-29223-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001725.1|refseq:NP_958850.1|ensembl:ENSG00000182326(gene)|ensembl:ENST00000328916(transcript)|ensembl:ENST00000360817(transcript)|ensembl:ENST00000406697(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0072562"(blood microparticle)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR000859(CUB)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR018097|interpro:IPR033116|interpro:IPR035708|interpro:IPR035914|interpro:IPR035976|interpro:IPR043504|rcsb pdb:1ELV|rcsb pdb:1NZI|rcsb pdb:4J1Y|rcsb pdb:4LMF|rcsb pdb:4LOR|rcsb pdb:4LOS|rcsb pdb:4LOT|rcsb pdb:6F1C|rcsb pdb:6F1H|reactome:R-HSA-166663|reactome:R-HSA-173623|reactome:R-HSA-977606|refseq:NP_001333779.1|refseq:XP_005253817.1	refseq:NP_000053.2|refseq:NP_001027466.1|dip:DIP-45635N|ensembl:ENSG00000149131(gene)|ensembl:ENST00000278407(transcript)|ensembl:ENST00000676670(transcript)|go:"GO:0001869"(negative regulation of complement activation, lectin pathway)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0007568"(aging)|go:"GO:0007596"(blood coagulation)|go:"GO:0008015"(blood circulation)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0042730"(fibrinolysis)|go:"GO:0045087"(innate immune response)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR015553(Protease inhibitor I4, serpin C1)|interpro:IPR023795|interpro:IPR023796|interpro:IPR036186|interpro:IPR042178|interpro:IPR042185|mint:P05155|rcsb pdb:1M6Q|rcsb pdb:2OAY|rcsb pdb:5DU3|rcsb pdb:5DUQ|rcsb pdb:7AKV|reactome:R-HSA-114608|reactome:R-HSA-140837|reactome:R-HSA-9657689|reactome:R-HSA-977606	-	-	-	figure legend:2C|comment:Excess amounts of C1-Inh were required to inhibit C1s activity.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/17	2021/09/16	rogid:3zz5RwIqLyPO71zdCp5Vx7aVl+Y9606	rogid:Y7cqCZ6Ryz51dsi6jM86EXdfeWc9606	-	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:180472"	uniprotkb:P09871	intact:EBI-27087858	intact:EBI-2810045|uniprotkb:Q9UCU9|uniprotkb:Q9UCV3|uniprotkb:Q9UCU7|uniprotkb:Q9UCV5|uniprotkb:Q9UCV4|uniprotkb:Q9UCU8|uniprotkb:Q9UCV2|uniprotkb:Q9UCV1|uniprotkb:Q9UCV0|uniprotkb:Q9UM14|uniprotkb:D3DUT4|ensembl:ENSP00000328173|ensembl:ENSP00000354057|ensembl:ENSP00000385035	psi-mi:z-l-lys-sbzl hydrochloride(display_short)|psi-mi:"CHEBI:180472"(display_long)	psi-mi:c1s_human(display_long)|uniprotkb:C1S(gene name)|psi-mi:C1S(display_short)|uniprotkb:C1 esterase(gene name synonym)|uniprotkb:Complement component 1 subcomponent s(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Keizer et al. (2015)	pubmed:25359215|imex:IM-29223	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27087929|imex:IM-29223-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001725.1|refseq:NP_958850.1|ensembl:ENSG00000182326(gene)|ensembl:ENST00000328916(transcript)|ensembl:ENST00000360817(transcript)|ensembl:ENST00000406697(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0072562"(blood microparticle)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR000859(CUB)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR018097|interpro:IPR033116|interpro:IPR035708|interpro:IPR035914|interpro:IPR035976|interpro:IPR043504|rcsb pdb:1ELV|rcsb pdb:1NZI|rcsb pdb:4J1Y|rcsb pdb:4LMF|rcsb pdb:4LOR|rcsb pdb:4LOS|rcsb pdb:4LOT|rcsb pdb:6F1C|rcsb pdb:6F1H|reactome:R-HSA-166663|reactome:R-HSA-173623|reactome:R-HSA-977606|refseq:NP_001333779.1|refseq:XP_005253817.1	-	-	-	figure legend:2C|comment:Excess amounts of C1-Inh were required to inhibit C1s activity.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/17	2021/09/16	-	rogid:3zz5RwIqLyPO71zdCp5Vx7aVl+Y9606	-	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:180472"	uniprotkb:P09871	intact:EBI-27087858	intact:EBI-2810045|uniprotkb:Q9UCU9|uniprotkb:Q9UCV3|uniprotkb:Q9UCU7|uniprotkb:Q9UCV5|uniprotkb:Q9UCV4|uniprotkb:Q9UCU8|uniprotkb:Q9UCV2|uniprotkb:Q9UCV1|uniprotkb:Q9UCV0|uniprotkb:Q9UM14|uniprotkb:D3DUT4|ensembl:ENSP00000328173|ensembl:ENSP00000354057|ensembl:ENSP00000385035	psi-mi:z-l-lys-sbzl hydrochloride(display_short)|psi-mi:"CHEBI:180472"(display_long)	psi-mi:c1s_human(display_long)|uniprotkb:C1S(gene name)|psi-mi:C1S(display_short)|uniprotkb:C1 esterase(gene name synonym)|uniprotkb:Complement component 1 subcomponent s(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Keizer et al. (2015)	pubmed:25359215|imex:IM-29223	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27087934|imex:IM-29223-11	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001725.1|refseq:NP_958850.1|ensembl:ENSG00000182326(gene)|ensembl:ENST00000328916(transcript)|ensembl:ENST00000360817(transcript)|ensembl:ENST00000406697(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0072562"(blood microparticle)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR000859(CUB)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR018097|interpro:IPR033116|interpro:IPR035708|interpro:IPR035914|interpro:IPR035976|interpro:IPR043504|rcsb pdb:1ELV|rcsb pdb:1NZI|rcsb pdb:4J1Y|rcsb pdb:4LMF|rcsb pdb:4LOR|rcsb pdb:4LOS|rcsb pdb:4LOT|rcsb pdb:6F1C|rcsb pdb:6F1H|reactome:R-HSA-166663|reactome:R-HSA-173623|reactome:R-HSA-977606|refseq:NP_001333779.1|refseq:XP_005253817.1	-	-	-	figure legend:2C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/17	2021/09/16	-	rogid:3zz5RwIqLyPO71zdCp5Vx7aVl+Y9606	-	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)