#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P51148	uniprotkb:Q5ZRP9	intact:EBI-1054923|intact:EBI-2798296|uniprotkb:Q9P0Y5|uniprotkb:Q6FH55|uniprotkb:F8W1H5|ensembl:ENSP00000345689|ensembl:ENSP00000377440	intact:EBI-26364295|ensemblbacteria:AAU28879	psi-mi:rab5c_human(display_long)|uniprotkb:RABL(gene name synonym)|uniprotkb:RAB5C(gene name)|psi-mi:RAB5C(display_short)|uniprotkb:RAB5L(gene name synonym)|uniprotkb:L1880(gene name synonym)	psi-mi:q5zrp9_legph(display_long)|uniprotkb:vipD(gene name)|psi-mi:vipD(display_short)|uniprotkb:lpg2831(locus name)	psi-mi:"MI:0114"(x-ray crystallography)	Lucas et al. (2014)	pubmed:25114243|imex:IM-28402	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:272624(legph)|taxid:272624(Legionella pneumophila subsp. pneumophila)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-26364308|imex:IM-28402-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004574.2|refseq:NP_958842.1|refseq:XP_011523392.1|refseq:XP_011523393.1|refseq:NP_001238968.1|ensembl:ENSG00000108774(gene)|ensembl:ENST00000346213(transcript)|ensembl:ENST00000393860(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005811"(lipid droplet)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0012505"(endomembrane system)|go:"GO:0019003"(GDP binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042470"(melanosome)|go:"GO:0048227"(plasma membrane to endosome transport)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|rcsb pdb:4KYI|reactome:R-HSA-432722|reactome:R-HSA-6798695|reactome:R-HSA-8854214|reactome:R-HSA-8856828|reactome:R-HSA-8873719|reactome:R-HSA-8876198	ensemblbacteria:AAU28879(transcript)|ensemblbacteria:lpg2831(gene)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016787"(hydrolase activity)|refseq:YP_096826.1|rcsb pdb:4AKF|rcsb pdb:4KYI|interpro:IPR016035(Acyl transferase/acyl hydrolase/lysophospholipase)|interpro:IPR002641(Patatin)	pdbe:4kyi	-	-	figure legend:f1 f2 t1 sf1|comment:"he final model for the VipD19–564-Rab5c18–182(Q80L)-GppNHp structure was refined at 3.1 Å, with values for Rfactor and Rfree of 0.23 and 0.28, respectively"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/10/05	2020/10/06	rogid:sz3lmmxPJk0/IzQ9dZF0PzfNhBY9606	rogid:+GMms/JxD2Ftf8LsGcwSINkoIaY272624	rigid:4AOfcuQ06NmTWIifJKHTT/wuLwA	false	mutation:80-80|binding-associated region:18-182	binding-associated region:19-564	2	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P51148	uniprotkb:Q5ZRP9	intact:EBI-1054923|intact:EBI-2798296|uniprotkb:Q9P0Y5|uniprotkb:Q6FH55|uniprotkb:F8W1H5|ensembl:ENSP00000345689|ensembl:ENSP00000377440	intact:EBI-26364295|ensemblbacteria:AAU28879	psi-mi:rab5c_human(display_long)|uniprotkb:RABL(gene name synonym)|uniprotkb:RAB5C(gene name)|psi-mi:RAB5C(display_short)|uniprotkb:RAB5L(gene name synonym)|uniprotkb:L1880(gene name synonym)	psi-mi:q5zrp9_legph(display_long)|uniprotkb:vipD(gene name)|psi-mi:vipD(display_short)|uniprotkb:lpg2831(locus name)	psi-mi:"MI:0096"(pull down)	Lucas et al. (2014)	pubmed:25114243|imex:IM-28402	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:272624(legph)|taxid:272624(Legionella pneumophila subsp. pneumophila)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-26364339|imex:IM-28402-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004574.2|refseq:NP_958842.1|refseq:XP_011523392.1|refseq:XP_011523393.1|refseq:NP_001238968.1|ensembl:ENSG00000108774(gene)|ensembl:ENST00000346213(transcript)|ensembl:ENST00000393860(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005811"(lipid droplet)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0012505"(endomembrane system)|go:"GO:0019003"(GDP binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042470"(melanosome)|go:"GO:0048227"(plasma membrane to endosome transport)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|rcsb pdb:4KYI|reactome:R-HSA-432722|reactome:R-HSA-6798695|reactome:R-HSA-8854214|reactome:R-HSA-8856828|reactome:R-HSA-8873719|reactome:R-HSA-8876198	ensemblbacteria:AAU28879(transcript)|ensemblbacteria:lpg2831(gene)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016787"(hydrolase activity)|refseq:YP_096826.1|rcsb pdb:4AKF|rcsb pdb:4KYI|interpro:IPR016035(Acyl transferase/acyl hydrolase/lysophospholipase)|interpro:IPR002641(Patatin)	-	-	-	figure legend:f4a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/10/05	2020/10/05	rogid:sz3lmmxPJk0/IzQ9dZF0PzfNhBY9606	rogid:+GMms/JxD2Ftf8LsGcwSINkoIaY272624	rigid:4AOfcuQ06NmTWIifJKHTT/wuLwA	false	mutation:80-80|binding-associated region:18-182	mutation disrupting interaction:442-442|glutathione s tranferase tag:n-n|mutation decreasing interaction:449-449|mutation disrupting interaction:453-453|mutation decreasing interaction:461-461|mutation decreasing interaction:473-473|mutation with no effect:476-476|mutation decreasing interaction:479-479|mutation with no effect:484-484	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:P51148	uniprotkb:Q5ZRP9	intact:EBI-1054923|intact:EBI-2798296|uniprotkb:Q9P0Y5|uniprotkb:Q6FH55|uniprotkb:F8W1H5|ensembl:ENSP00000345689|ensembl:ENSP00000377440	intact:EBI-26364295|ensemblbacteria:AAU28879	psi-mi:rab5c_human(display_long)|uniprotkb:RABL(gene name synonym)|uniprotkb:RAB5C(gene name)|psi-mi:RAB5C(display_short)|uniprotkb:RAB5L(gene name synonym)|uniprotkb:L1880(gene name synonym)	psi-mi:q5zrp9_legph(display_long)|uniprotkb:vipD(gene name)|psi-mi:vipD(display_short)|uniprotkb:lpg2831(locus name)	psi-mi:"MI:0096"(pull down)	Lucas et al. (2014)	pubmed:25114243|imex:IM-28402	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:272624(legph)|taxid:272624(Legionella pneumophila subsp. pneumophila)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-26364372|imex:IM-28402-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004574.2|refseq:NP_958842.1|refseq:XP_011523392.1|refseq:XP_011523393.1|refseq:NP_001238968.1|ensembl:ENSG00000108774(gene)|ensembl:ENST00000346213(transcript)|ensembl:ENST00000393860(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005811"(lipid droplet)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0012505"(endomembrane system)|go:"GO:0019003"(GDP binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042470"(melanosome)|go:"GO:0048227"(plasma membrane to endosome transport)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|rcsb pdb:4KYI|reactome:R-HSA-432722|reactome:R-HSA-6798695|reactome:R-HSA-8854214|reactome:R-HSA-8856828|reactome:R-HSA-8873719|reactome:R-HSA-8876198	ensemblbacteria:AAU28879(transcript)|ensemblbacteria:lpg2831(gene)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016787"(hydrolase activity)|refseq:YP_096826.1|rcsb pdb:4AKF|rcsb pdb:4KYI|interpro:IPR016035(Acyl transferase/acyl hydrolase/lysophospholipase)|interpro:IPR002641(Patatin)	-	-	-	figure legend:f4b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/10/05	2020/10/05	rogid:sz3lmmxPJk0/IzQ9dZF0PzfNhBY9606	rogid:+GMms/JxD2Ftf8LsGcwSINkoIaY272624	rigid:4AOfcuQ06NmTWIifJKHTT/wuLwA	false	mutation disrupting interaction:58-58|mutation with no effect:73-73|mutation decreasing interaction:75-75|mutation decreasing interaction:82-82|mutation disrupting interaction:83-83|mutation decreasing interaction:89-89|mutation with no effect:80-80|binding-associated region:18-182|glutathione s tranferase tag:n-n|mutation with no effect:90-90|mutation disrupting interaction:92-92	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:Q9UL26	uniprotkb:Q5ZRP9	intact:EBI-399456|uniprotkb:Q8TF12|uniprotkb:Q9H4E6|uniprotkb:B3KR86|uniprotkb:E1P605|ensembl:ENSP00000244040	intact:EBI-26364295|ensemblbacteria:AAU28879	psi-mi:rb22a_human(display_long)|uniprotkb:RAB22A(gene name)|psi-mi:RAB22A(display_short)|uniprotkb:RAB22(gene name synonym)	psi-mi:q5zrp9_legph(display_long)|uniprotkb:vipD(gene name)|psi-mi:vipD(display_short)|uniprotkb:lpg2831(locus name)	psi-mi:"MI:0096"(pull down)	Lucas et al. (2014)	pubmed:25114243|imex:IM-28402	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:272624(legph)|taxid:272624(Legionella pneumophila subsp. pneumophila)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-26364446|imex:IM-28402-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_065724.1|ensembl:ENSG00000124209(gene)|ensembl:ENST00000244040(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0007032"(endosome organization)|go:"GO:0010008"(endosome membrane)|go:"GO:0012505"(endomembrane system)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019003"(GDP binding)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097494"(regulation of vesicle size)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:Q9UL26|reactome:R-HSA-8873719	ensemblbacteria:AAU28879(transcript)|ensemblbacteria:lpg2831(gene)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016787"(hydrolase activity)|refseq:YP_096826.1|rcsb pdb:4AKF|rcsb pdb:4KYI|interpro:IPR016035(Acyl transferase/acyl hydrolase/lysophospholipase)|interpro:IPR002641(Patatin)	-	-	-	figure legend:f4C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/10/05	2020/10/06	rogid:K6gpzvSza/iYmgPSX0RHLH6y7qM9606	rogid:+GMms/JxD2Ftf8LsGcwSINkoIaY272624	rigid:pNA68tF37DxZHa0qOs5w0vlQxfI	false	mutation:64-64|binding-associated region:18-182	mutation disrupting interaction:442-442|glutathione s tranferase tag:n-n|mutation disrupting interaction:449-449|mutation decreasing interaction:453-453|mutation disrupting interaction:461-461|mutation decreasing interaction:473-473|mutation with no effect:476-476|mutation decreasing interaction:479-479|mutation with no effect:484-484	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:P51148	uniprotkb:Q5ZRP9	intact:EBI-1054923|intact:EBI-2798296|uniprotkb:Q9P0Y5|uniprotkb:Q6FH55|uniprotkb:F8W1H5|ensembl:ENSP00000345689|ensembl:ENSP00000377440	intact:EBI-26364295|ensemblbacteria:AAU28879	psi-mi:rab5c_human(display_long)|uniprotkb:RABL(gene name synonym)|uniprotkb:RAB5C(gene name)|psi-mi:RAB5C(display_short)|uniprotkb:RAB5L(gene name synonym)|uniprotkb:L1880(gene name synonym)	psi-mi:q5zrp9_legph(display_long)|uniprotkb:vipD(gene name)|psi-mi:vipD(display_short)|uniprotkb:lpg2831(locus name)	psi-mi:"MI:0107"(surface plasmon resonance)	Lucas et al. (2014)	pubmed:25114243|imex:IM-28402	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:272624(legph)|taxid:272624(Legionella pneumophila subsp. pneumophila)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-26364594|imex:IM-28402-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004574.2|refseq:NP_958842.1|refseq:XP_011523392.1|refseq:XP_011523393.1|refseq:NP_001238968.1|ensembl:ENSG00000108774(gene)|ensembl:ENST00000346213(transcript)|ensembl:ENST00000393860(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005811"(lipid droplet)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0012505"(endomembrane system)|go:"GO:0019003"(GDP binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042470"(melanosome)|go:"GO:0048227"(plasma membrane to endosome transport)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|rcsb pdb:4KYI|reactome:R-HSA-432722|reactome:R-HSA-6798695|reactome:R-HSA-8854214|reactome:R-HSA-8856828|reactome:R-HSA-8873719|reactome:R-HSA-8876198	ensemblbacteria:AAU28879(transcript)|ensemblbacteria:lpg2831(gene)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016787"(hydrolase activity)|refseq:YP_096826.1|rcsb pdb:4AKF|rcsb pdb:4KYI|interpro:IPR016035(Acyl transferase/acyl hydrolase/lysophospholipase)|interpro:IPR002641(Patatin)	-	-	-	figure legend:f7b f7c sf6|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:0.11x10^-6(molar)	2020/10/05	2020/10/06	rogid:sz3lmmxPJk0/IzQ9dZF0PzfNhBY9606	rogid:+GMms/JxD2Ftf8LsGcwSINkoIaY272624	rigid:4AOfcuQ06NmTWIifJKHTT/wuLwA	false	mutation:80-80|binding-associated region:18-182|mutation decreasing interaction:92-92	glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P51148	uniprotkb:Q15075	intact:EBI-1054923|intact:EBI-2798296|uniprotkb:Q9P0Y5|uniprotkb:Q6FH55|uniprotkb:F8W1H5|ensembl:ENSP00000345689|ensembl:ENSP00000377440	intact:EBI-298113|uniprotkb:Q14221|ensembl:ENSP00000317955	psi-mi:rab5c_human(display_long)|uniprotkb:RABL(gene name synonym)|uniprotkb:RAB5C(gene name)|psi-mi:RAB5C(display_short)|uniprotkb:RAB5L(gene name synonym)|uniprotkb:L1880(gene name synonym)	psi-mi:eea1_human(display_long)|uniprotkb:EEA1(gene name)|psi-mi:EEA1(display_short)|uniprotkb:ZFYVE2(gene name synonym)|uniprotkb:Endosome-associated protein p162(gene name synonym)|uniprotkb:Zinc finger FYVE domain-containing protein 2(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Lucas et al. (2014)	pubmed:25114243|imex:IM-28402	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-26364613|imex:IM-28402-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004574.2|refseq:NP_958842.1|refseq:XP_011523392.1|refseq:XP_011523393.1|refseq:NP_001238968.1|ensembl:ENSG00000108774(gene)|ensembl:ENST00000346213(transcript)|ensembl:ENST00000393860(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005811"(lipid droplet)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0012505"(endomembrane system)|go:"GO:0019003"(GDP binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042470"(melanosome)|go:"GO:0048227"(plasma membrane to endosome transport)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|rcsb pdb:4KYI|reactome:R-HSA-432722|reactome:R-HSA-6798695|reactome:R-HSA-8854214|reactome:R-HSA-8856828|reactome:R-HSA-8873719|reactome:R-HSA-8876198	ensembl:ENSG00000102189(gene)|ensembl:ENST00000322349(transcript)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005969"(serine-pyruvate aminotransferase complex)|go:"GO:0006897"(endocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0016189"(synaptic vesicle to endosome fusion)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044308"(axonal spine)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR017455(Zinc finger, FYVE-related)|mint:Q15075|rcsb pdb:1HYI|rcsb pdb:1HYJ|rcsb pdb:1JOC|rcsb pdb:3MJH|reactome:R-HSA-168138|refseq:NP_003557.2	-	-	-	figure legend:f7b f7c sf6|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:7.4x10^-6(molar)	2020/10/05	2020/10/06	rogid:sz3lmmxPJk0/IzQ9dZF0PzfNhBY9606	rogid:aKGquyBsTFm+hhbJiIbz1Lv88Hw9606	rigid:iXCthlXASItRp6DTOd1h6c+2Auo	false	mutation:80-80|binding-associated region:18-182|mutation decreasing interaction:92-92	glutathione s tranferase tag:n-n|binding-associated region:36-91	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P51148	uniprotkb:Q9H1K0	intact:EBI-1054923|intact:EBI-2798296|uniprotkb:Q9P0Y5|uniprotkb:Q6FH55|uniprotkb:F8W1H5|ensembl:ENSP00000345689|ensembl:ENSP00000377440	intact:EBI-1105310|uniprotkb:Q3KP30|uniprotkb:Q59EY8|uniprotkb:Q8NAQ1|uniprotkb:B4DWY8|uniprotkb:C9J4P5|ensembl:ENSP00000253699|ensembl:ENSP00000422551	psi-mi:rab5c_human(display_long)|uniprotkb:RABL(gene name synonym)|uniprotkb:RAB5C(gene name)|psi-mi:RAB5C(display_short)|uniprotkb:RAB5L(gene name synonym)|uniprotkb:L1880(gene name synonym)	psi-mi:rbns5_human(display_long)|uniprotkb:RBSN(gene name)|psi-mi:RBSN(display_short)|uniprotkb:110 kDa protein(gene name synonym)|uniprotkb:FYVE finger-containing Rab5 effector protein rabenosyn-5(gene name synonym)|uniprotkb:RAB effector RBSN(gene name synonym)|uniprotkb:ZFYVE20(gene name synonym)|uniprotkb:Zinc finger FYVE domain-containing protein 20(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Lucas et al. (2014)	pubmed:25114243|imex:IM-28402	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-26364631|imex:IM-28402-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004574.2|refseq:NP_958842.1|refseq:XP_011523392.1|refseq:XP_011523393.1|refseq:NP_001238968.1|ensembl:ENSG00000108774(gene)|ensembl:ENST00000346213(transcript)|ensembl:ENST00000393860(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005811"(lipid droplet)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0012505"(endomembrane system)|go:"GO:0019003"(GDP binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042470"(melanosome)|go:"GO:0048227"(plasma membrane to endosome transport)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|rcsb pdb:4KYI|reactome:R-HSA-432722|reactome:R-HSA-6798695|reactome:R-HSA-8854214|reactome:R-HSA-8856828|reactome:R-HSA-8873719|reactome:R-HSA-8876198	refseq:NP_071735.2|refseq:NP_001289307.1|ensembl:ENSG00000131381(gene)|ensembl:ENST00000253699(transcript)|ensembl:ENST00000476527(transcript)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010008"(endosome membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0031901"(early endosome membrane)|go:"GO:0034498"(early endosome to Golgi transport)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090160"(Golgi to lysosome transport)|go:"GO:1903358"(regulation of Golgi organization)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR021565|interpro:IPR036531|mint:Q9H1K0|rcsb pdb:1YZM|rcsb pdb:1Z0J|rcsb pdb:1Z0K|reactome:R-HSA-168138|reactome:R-HSA-983231|refseq:XP_005265441.1|refseq:XP_005265442.1|refseq:XP_016862512.1	-	-	-	figure legend:f7b f7c sf6|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:12.3x10^-6(molar)	2020/10/05	2020/10/06	rogid:sz3lmmxPJk0/IzQ9dZF0PzfNhBY9606	rogid:fKkis2EhJdqQj04oUTABbwxEI2Y9606	rigid:81bOuDCppBSt2A5XDLozTS7WTnQ	false	mutation:80-80|binding-associated region:18-182|mutation decreasing interaction:92-92	glutathione s tranferase tag:n-n|binding-associated region:1-70	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P51148	uniprotkb:Q15276	intact:EBI-1054923|intact:EBI-2798296|uniprotkb:Q9P0Y5|uniprotkb:Q6FH55|uniprotkb:F8W1H5|ensembl:ENSP00000345689|ensembl:ENSP00000377440	intact:EBI-447043|uniprotkb:O95369|uniprotkb:Q8IVX3|uniprotkb:B2RAG7|ensembl:ENSP00000445408	psi-mi:rab5c_human(display_long)|uniprotkb:RABL(gene name synonym)|uniprotkb:RAB5C(gene name)|psi-mi:RAB5C(display_short)|uniprotkb:RAB5L(gene name synonym)|uniprotkb:L1880(gene name synonym)	psi-mi:rabe1_human(display_long)|uniprotkb:Rabaptin-5(gene name synonym)|uniprotkb:Rabaptin-5alpha(gene name synonym)|uniprotkb:Rabaptin-4(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-17(gene name synonym)|uniprotkb:RABEP1(gene name)|psi-mi:RABEP1(display_short)|uniprotkb:RABPT5(gene name synonym)|uniprotkb:RABPT5A(gene name synonym)|uniprotkb:RAB5EP(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Lucas et al. (2014)	pubmed:25114243|imex:IM-28402	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-26364649|imex:IM-28402-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004574.2|refseq:NP_958842.1|refseq:XP_011523392.1|refseq:XP_011523393.1|refseq:NP_001238968.1|ensembl:ENSG00000108774(gene)|ensembl:ENST00000346213(transcript)|ensembl:ENST00000393860(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005811"(lipid droplet)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0012505"(endomembrane system)|go:"GO:0019003"(GDP binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042470"(melanosome)|go:"GO:0048227"(plasma membrane to endosome transport)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|rcsb pdb:4KYI|reactome:R-HSA-432722|reactome:R-HSA-6798695|reactome:R-HSA-8854214|reactome:R-HSA-8856828|reactome:R-HSA-8873719|reactome:R-HSA-8876198	refseq:NP_001278510.1|refseq:NP_001077054.1|refseq:NP_004694.2|dip:DIP-29350N|go:"GO:0008083"(growth factor activity)|go:"GO:0015031"(protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0055037"(recycling endosome)|go:"GO:0061025"(membrane fusion)|go:"GO:1903441"(protein localization to ciliary membrane)|interpro:IPR003914(Rabaptin)|interpro:IPR015390(Rabaptin, GTPase-Rab5 binding)|interpro:IPR018514|interpro:IPR029880|rcsb pdb:1P4U|rcsb pdb:1TU3|rcsb pdb:1X79|rcsb pdb:4N3Y|rcsb pdb:4N3Z|rcsb pdb:4Q9U|reactome:R-HSA-8854214|ensembl:ENSG00000029725(gene)|ensembl:ENST00000537505(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0006897"(endocytosis)|go:"GO:0006915"(apoptotic process)	-	-	-	figure legend:f7b f7c sf6|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/10/05	2020/10/06	rogid:sz3lmmxPJk0/IzQ9dZF0PzfNhBY9606	rogid:FDHgN8w6jbAPC3iQfeLY6sdLkrs9606	rigid:C1NVNsa8hTKThmEC/ve75PixL+Y	false	mutation:80-80|binding-associated region:18-182|mutation with no effect:92-92	glutathione s tranferase tag:n-n|binding-associated region:739-862	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P51148	uniprotkb:Q5ZRP9	intact:EBI-1054923|intact:EBI-2798296|uniprotkb:Q9P0Y5|uniprotkb:Q6FH55|uniprotkb:F8W1H5|ensembl:ENSP00000345689|ensembl:ENSP00000377440	intact:EBI-26364295|ensemblbacteria:AAU28879	psi-mi:rab5c_human(display_long)|uniprotkb:RABL(gene name synonym)|uniprotkb:RAB5C(gene name)|psi-mi:RAB5C(display_short)|uniprotkb:RAB5L(gene name synonym)|uniprotkb:L1880(gene name synonym)	psi-mi:q5zrp9_legph(display_long)|uniprotkb:vipD(gene name)|psi-mi:vipD(display_short)|uniprotkb:lpg2831(locus name)	psi-mi:"MI:0416"(fluorescence microscopy)	Lucas et al. (2014)	pubmed:25114243|imex:IM-28402	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:272624(legph)|taxid:272624(Legionella pneumophila subsp. pneumophila)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-26364674|imex:IM-28402-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004574.2|refseq:NP_958842.1|refseq:XP_011523392.1|refseq:XP_011523393.1|refseq:NP_001238968.1|ensembl:ENSG00000108774(gene)|ensembl:ENST00000346213(transcript)|ensembl:ENST00000393860(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005811"(lipid droplet)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0012505"(endomembrane system)|go:"GO:0019003"(GDP binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042470"(melanosome)|go:"GO:0048227"(plasma membrane to endosome transport)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|rcsb pdb:4KYI|reactome:R-HSA-432722|reactome:R-HSA-6798695|reactome:R-HSA-8854214|reactome:R-HSA-8856828|reactome:R-HSA-8873719|reactome:R-HSA-8876198	ensemblbacteria:AAU28879(transcript)|ensemblbacteria:lpg2831(gene)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016787"(hydrolase activity)|refseq:YP_096826.1|rcsb pdb:4AKF|rcsb pdb:4KYI|interpro:IPR016035(Acyl transferase/acyl hydrolase/lysophospholipase)|interpro:IPR002641(Patatin)	go:"GO:0005768"(endosome)	-	-	figure legend:f5|caution:The figure shows Rab5a-Q79L, not Rab5c-Q80L, but the text refers to Rab5c-Q80L. We believe it is probably a typo error and curated the interaction with Rab5c.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2020/10/05	2020/10/06	rogid:sz3lmmxPJk0/IzQ9dZF0PzfNhBY9606	rogid:+GMms/JxD2Ftf8LsGcwSINkoIaY272624	rigid:4AOfcuQ06NmTWIifJKHTT/wuLwA	false	green fluorescent protein tag:n-n|mutation:80-80|binding-associated region:18-182	mutation disrupting interaction:442-442|mcherry fluorescent protein tag:n-n|mutation with no effect:476-476|mutation with no effect:461-461	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:P51148	uniprotkb:Q5ZRP9	intact:EBI-1054923|intact:EBI-2798296|uniprotkb:Q9P0Y5|uniprotkb:Q6FH55|uniprotkb:F8W1H5|ensembl:ENSP00000345689|ensembl:ENSP00000377440	intact:EBI-26364295|ensemblbacteria:AAU28879	psi-mi:rab5c_human(display_long)|uniprotkb:RABL(gene name synonym)|uniprotkb:RAB5C(gene name)|psi-mi:RAB5C(display_short)|uniprotkb:RAB5L(gene name synonym)|uniprotkb:L1880(gene name synonym)	psi-mi:q5zrp9_legph(display_long)|uniprotkb:vipD(gene name)|psi-mi:vipD(display_short)|uniprotkb:lpg2831(locus name)	psi-mi:"MI:0071"(molecular sieving)	Lucas et al. (2014)	pubmed:25114243|imex:IM-28402	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:272624(legph)|taxid:272624(Legionella pneumophila subsp. pneumophila)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-26364713|imex:IM-28402-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004574.2|refseq:NP_958842.1|refseq:XP_011523392.1|refseq:XP_011523393.1|refseq:NP_001238968.1|ensembl:ENSG00000108774(gene)|ensembl:ENST00000346213(transcript)|ensembl:ENST00000393860(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005811"(lipid droplet)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0012505"(endomembrane system)|go:"GO:0019003"(GDP binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042470"(melanosome)|go:"GO:0048227"(plasma membrane to endosome transport)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|rcsb pdb:4KYI|reactome:R-HSA-432722|reactome:R-HSA-6798695|reactome:R-HSA-8854214|reactome:R-HSA-8856828|reactome:R-HSA-8873719|reactome:R-HSA-8876198	ensemblbacteria:AAU28879(transcript)|ensemblbacteria:lpg2831(gene)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016787"(hydrolase activity)|refseq:YP_096826.1|rcsb pdb:4AKF|rcsb pdb:4KYI|interpro:IPR016035(Acyl transferase/acyl hydrolase/lysophospholipase)|interpro:IPR002641(Patatin)	-	-	-	figure legend:sf3|comment:"Small angle X-ray scattering (SAXS) and gel filtration chromatography analysis suggest a heterodimeric VipD1–621–Rab5c18–182(Q80L) complex in solution, indicating that N18 was not involved in any oligomer formation (Fig. 6 A and B and Fig. S3)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/10/05	2020/10/06	rogid:sz3lmmxPJk0/IzQ9dZF0PzfNhBY9606	rogid:+GMms/JxD2Ftf8LsGcwSINkoIaY272624	rigid:4AOfcuQ06NmTWIifJKHTT/wuLwA	false	mutation:80-80|binding-associated region:18-182	binding-associated region:1-621	2	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P51148	uniprotkb:Q5ZRP9	intact:EBI-1054923|intact:EBI-2798296|uniprotkb:Q9P0Y5|uniprotkb:Q6FH55|uniprotkb:F8W1H5|ensembl:ENSP00000345689|ensembl:ENSP00000377440	intact:EBI-26364295|ensemblbacteria:AAU28879	psi-mi:rab5c_human(display_long)|uniprotkb:RABL(gene name synonym)|uniprotkb:RAB5C(gene name)|psi-mi:RAB5C(display_short)|uniprotkb:RAB5L(gene name synonym)|uniprotkb:L1880(gene name synonym)	psi-mi:q5zrp9_legph(display_long)|uniprotkb:vipD(gene name)|psi-mi:vipD(display_short)|uniprotkb:lpg2831(locus name)	psi-mi:"MI:0826"(x ray scattering)	Lucas et al. (2014)	pubmed:25114243|imex:IM-28402	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:272624(legph)|taxid:272624(Legionella pneumophila subsp. pneumophila)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-26364761|imex:IM-28402-23	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004574.2|refseq:NP_958842.1|refseq:XP_011523392.1|refseq:XP_011523393.1|refseq:NP_001238968.1|ensembl:ENSG00000108774(gene)|ensembl:ENST00000346213(transcript)|ensembl:ENST00000393860(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005811"(lipid droplet)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0012505"(endomembrane system)|go:"GO:0019003"(GDP binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042470"(melanosome)|go:"GO:0048227"(plasma membrane to endosome transport)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|rcsb pdb:4KYI|reactome:R-HSA-432722|reactome:R-HSA-6798695|reactome:R-HSA-8854214|reactome:R-HSA-8856828|reactome:R-HSA-8873719|reactome:R-HSA-8876198	ensemblbacteria:AAU28879(transcript)|ensemblbacteria:lpg2831(gene)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016787"(hydrolase activity)|refseq:YP_096826.1|rcsb pdb:4AKF|rcsb pdb:4KYI|interpro:IPR016035(Acyl transferase/acyl hydrolase/lysophospholipase)|interpro:IPR002641(Patatin)	-	-	-	figure legend:f6|comment:"Small angle X-ray scattering (SAXS) and gel filtration chromatography analysis suggest a heterodimeric VipD1–621–Rab5c18–182(Q80L) complex in solution, indicating that N18 was not involved in any oligomer formation (Fig. 6 A and B and Fig. S3)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/10/05	2020/10/06	rogid:sz3lmmxPJk0/IzQ9dZF0PzfNhBY9606	rogid:+GMms/JxD2Ftf8LsGcwSINkoIaY272624	rigid:4AOfcuQ06NmTWIifJKHTT/wuLwA	false	mutation:80-80|binding-associated region:18-182	binding-associated region:19-564	2	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)