#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q96R06 uniprotkb:Q9BZF1 intact:EBI-413317|uniprotkb:O95213|uniprotkb:Q9BWE8|uniprotkb:Q9NT17|uniprotkb:Q9UFE6|intact:EBI-28972684|ensembl:ENSP00000323300 intact:EBI-2684038|uniprotkb:Q52LQ3|uniprotkb:Q9P277|uniprotkb:Q8WXP8|uniprotkb:A8K1T2|uniprotkb:E9PE66|uniprotkb:E9PE68|uniprotkb:Q68D75|ensembl:ENSP00000261183 psi-mi:spag5_human(display_long)|uniprotkb:SPAG5(gene name)|psi-mi:SPAG5(display_short)|uniprotkb:Astrin(gene name synonym)|uniprotkb:Mitotic spindle-associated protein p126(gene name synonym)|uniprotkb:Deepest(gene name synonym) psi-mi:osbl8_human(display_long)|uniprotkb:KIAA1451(gene name synonym)|uniprotkb:ORP8(gene name synonym)|uniprotkb:OSBP10(gene name synonym)|uniprotkb:OSBPL8(gene name)|psi-mi:OSBPL8(display_short) psi-mi:"MI:0018"(two hybrid) Zhong et al. (2014) imex:IM-28061|pubmed:24424245 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-25466806|imex:IM-28061-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006452.3|ensembl:ENSP00000323300|ensembl:ENSG00000076382(gene)|ensembl:ENST00000321765(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000776"(kinetochore)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007051"(spindle organization)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008017"(microtubule binding)|go:"GO:0016604"(nuclear body)|go:"GO:0030496"(midbody)|go:"GO:0032388"(positive regulation of intracellular transport)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035253"(ciliary rootlet)|go:"GO:0035371"(microtubule plus-end)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051294"(establishment of spindle orientation)|go:"GO:0051301"(cell division)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090235"(regulation of metaphase plate congression)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:1905832"(positive regulation of spindle assembly)|interpro:IPR028728|mint:Q96R06|dip:DIP-30998N refseq:NP_001003712.1|refseq:NP_065892.1|refseq:NP_001306581.1|refseq:NP_001306584.1|ensembl:ENSG00000091039(gene)|ensembl:ENST00000261183(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005548"(phospholipid transporter activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010891"(negative regulation of sequestering of triglyceride)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0015914"(phospholipid transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032541"(cortical endoplasmic reticulum)|go:"GO:0032934"(sterol binding)|go:"GO:0036150"(phosphatidylserine acyl-chain remodeling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0090204"(protein localization to nuclear pore)|go:"GO:0140343"(phosphatidylserine transfer activity)|interpro:IPR000648(Oxysterol-binding protein)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018494|interpro:IPR037239|mint:Q9BZF1|rcsb pdb:1V88|rcsb pdb:5U77|rcsb pdb:5U78|reactome:R-HSA-1482801|refseq:XP_005268678.1|refseq:XP_006719287.1|dip:DIP-56130N - - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/09 2020/03/09 rogid:WOMksaINKpqSxqeGIzbmcSRcgdw9606 rogid:KwZ5DFeGTIM3p/yP3XBNgr/v3O09606 rigid:7fbPf34bnA2HqVhz4bLUrhyXDuo false sufficient binding region:550..550-1193..1193 sufficient binding region:1-870 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q96R06 uniprotkb:Q9BZF1 intact:EBI-413317|uniprotkb:O95213|uniprotkb:Q9BWE8|uniprotkb:Q9NT17|uniprotkb:Q9UFE6|intact:EBI-28972684|ensembl:ENSP00000323300 intact:EBI-2684038|uniprotkb:Q52LQ3|uniprotkb:Q9P277|uniprotkb:Q8WXP8|uniprotkb:A8K1T2|uniprotkb:E9PE66|uniprotkb:E9PE68|uniprotkb:Q68D75|ensembl:ENSP00000261183 psi-mi:spag5_human(display_long)|uniprotkb:SPAG5(gene name)|psi-mi:SPAG5(display_short)|uniprotkb:Astrin(gene name synonym)|uniprotkb:Mitotic spindle-associated protein p126(gene name synonym)|uniprotkb:Deepest(gene name synonym) psi-mi:osbl8_human(display_long)|uniprotkb:KIAA1451(gene name synonym)|uniprotkb:ORP8(gene name synonym)|uniprotkb:OSBP10(gene name synonym)|uniprotkb:OSBPL8(gene name)|psi-mi:OSBPL8(display_short) psi-mi:"MI:0096"(pull down) Zhong et al. (2014) imex:IM-28061|pubmed:24424245 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-25466819|imex:IM-28061-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006452.3|ensembl:ENSP00000323300|ensembl:ENSG00000076382(gene)|ensembl:ENST00000321765(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000776"(kinetochore)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007051"(spindle organization)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008017"(microtubule binding)|go:"GO:0016604"(nuclear body)|go:"GO:0030496"(midbody)|go:"GO:0032388"(positive regulation of intracellular transport)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035253"(ciliary rootlet)|go:"GO:0035371"(microtubule plus-end)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051294"(establishment of spindle orientation)|go:"GO:0051301"(cell division)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090235"(regulation of metaphase plate congression)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:1905832"(positive regulation of spindle assembly)|interpro:IPR028728|mint:Q96R06|dip:DIP-30998N refseq:NP_001003712.1|refseq:NP_065892.1|refseq:NP_001306581.1|refseq:NP_001306584.1|ensembl:ENSG00000091039(gene)|ensembl:ENST00000261183(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005548"(phospholipid transporter activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010891"(negative regulation of sequestering of triglyceride)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0015914"(phospholipid transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032541"(cortical endoplasmic reticulum)|go:"GO:0032934"(sterol binding)|go:"GO:0036150"(phosphatidylserine acyl-chain remodeling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0090204"(protein localization to nuclear pore)|go:"GO:0140343"(phosphatidylserine transfer activity)|interpro:IPR000648(Oxysterol-binding protein)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018494|interpro:IPR037239|mint:Q9BZF1|rcsb pdb:1V88|rcsb pdb:5U77|rcsb pdb:5U78|reactome:R-HSA-1482801|refseq:XP_005268678.1|refseq:XP_006719287.1|dip:DIP-56130N - - - figure legend:Fig. 1A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/03/09 2020/08/03 rogid:WOMksaINKpqSxqeGIzbmcSRcgdw9606 rogid:KwZ5DFeGTIM3p/yP3XBNgr/v3O09606 rigid:7fbPf34bnA2HqVhz4bLUrhyXDuo false - sufficient binding region:1-870|glutathione s tranferase tag:n-n - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q96R06 uniprotkb:Q9BZF1 intact:EBI-413317|uniprotkb:O95213|uniprotkb:Q9BWE8|uniprotkb:Q9NT17|uniprotkb:Q9UFE6|intact:EBI-28972684|ensembl:ENSP00000323300 intact:EBI-2684038|uniprotkb:Q52LQ3|uniprotkb:Q9P277|uniprotkb:Q8WXP8|uniprotkb:A8K1T2|uniprotkb:E9PE66|uniprotkb:E9PE68|uniprotkb:Q68D75|ensembl:ENSP00000261183 psi-mi:spag5_human(display_long)|uniprotkb:SPAG5(gene name)|psi-mi:SPAG5(display_short)|uniprotkb:Astrin(gene name synonym)|uniprotkb:Mitotic spindle-associated protein p126(gene name synonym)|uniprotkb:Deepest(gene name synonym) psi-mi:osbl8_human(display_long)|uniprotkb:KIAA1451(gene name synonym)|uniprotkb:ORP8(gene name synonym)|uniprotkb:OSBP10(gene name synonym)|uniprotkb:OSBPL8(gene name)|psi-mi:OSBPL8(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Zhong et al. (2014) imex:IM-28061|pubmed:24424245 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-25466882|imex:IM-28061-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006452.3|ensembl:ENSP00000323300|ensembl:ENSG00000076382(gene)|ensembl:ENST00000321765(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000776"(kinetochore)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007051"(spindle organization)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008017"(microtubule binding)|go:"GO:0016604"(nuclear body)|go:"GO:0030496"(midbody)|go:"GO:0032388"(positive regulation of intracellular transport)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035253"(ciliary rootlet)|go:"GO:0035371"(microtubule plus-end)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051294"(establishment of spindle orientation)|go:"GO:0051301"(cell division)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090235"(regulation of metaphase plate congression)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:1905832"(positive regulation of spindle assembly)|interpro:IPR028728|mint:Q96R06|dip:DIP-30998N refseq:NP_001003712.1|refseq:NP_065892.1|refseq:NP_001306581.1|refseq:NP_001306584.1|ensembl:ENSG00000091039(gene)|ensembl:ENST00000261183(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005548"(phospholipid transporter activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010891"(negative regulation of sequestering of triglyceride)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0015914"(phospholipid transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032541"(cortical endoplasmic reticulum)|go:"GO:0032934"(sterol binding)|go:"GO:0036150"(phosphatidylserine acyl-chain remodeling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0090204"(protein localization to nuclear pore)|go:"GO:0140343"(phosphatidylserine transfer activity)|interpro:IPR000648(Oxysterol-binding protein)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018494|interpro:IPR037239|mint:Q9BZF1|rcsb pdb:1V88|rcsb pdb:5U77|rcsb pdb:5U78|reactome:R-HSA-1482801|refseq:XP_005268678.1|refseq:XP_006719287.1|dip:DIP-56130N - - - figure legend:Fig. 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).") - 2020/03/09 2020/03/09 rogid:WOMksaINKpqSxqeGIzbmcSRcgdw9606 rogid:KwZ5DFeGTIM3p/yP3XBNgr/v3O09606 rigid:7fbPf34bnA2HqVhz4bLUrhyXDuo false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9BZF1 uniprotkb:Q96R06 intact:EBI-2684038|uniprotkb:Q52LQ3|uniprotkb:Q9P277|uniprotkb:Q8WXP8|uniprotkb:A8K1T2|uniprotkb:E9PE66|uniprotkb:E9PE68|uniprotkb:Q68D75|ensembl:ENSP00000261183 intact:EBI-413317|uniprotkb:O95213|uniprotkb:Q9BWE8|uniprotkb:Q9NT17|uniprotkb:Q9UFE6|intact:EBI-28972684|ensembl:ENSP00000323300 psi-mi:osbl8_human(display_long)|uniprotkb:KIAA1451(gene name synonym)|uniprotkb:ORP8(gene name synonym)|uniprotkb:OSBP10(gene name synonym)|uniprotkb:OSBPL8(gene name)|psi-mi:OSBPL8(display_short) psi-mi:spag5_human(display_long)|uniprotkb:SPAG5(gene name)|psi-mi:SPAG5(display_short)|uniprotkb:Astrin(gene name synonym)|uniprotkb:Mitotic spindle-associated protein p126(gene name synonym)|uniprotkb:Deepest(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Zhong et al. (2014) imex:IM-28061|pubmed:24424245 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0486"(UniProt) intact:EBI-25466923|imex:IM-28061-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001003712.1|refseq:NP_065892.1|refseq:NP_001306581.1|refseq:NP_001306584.1|ensembl:ENSG00000091039(gene)|ensembl:ENST00000261183(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005548"(phospholipid transporter activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010891"(negative regulation of sequestering of triglyceride)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0015914"(phospholipid transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032541"(cortical endoplasmic reticulum)|go:"GO:0032934"(sterol binding)|go:"GO:0036150"(phosphatidylserine acyl-chain remodeling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0090204"(protein localization to nuclear pore)|go:"GO:0140343"(phosphatidylserine transfer activity)|interpro:IPR000648(Oxysterol-binding protein)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018494|interpro:IPR037239|mint:Q9BZF1|rcsb pdb:1V88|rcsb pdb:5U77|rcsb pdb:5U78|reactome:R-HSA-1482801|refseq:XP_005268678.1|refseq:XP_006719287.1|dip:DIP-56130N refseq:NP_006452.3|ensembl:ENSP00000323300|ensembl:ENSG00000076382(gene)|ensembl:ENST00000321765(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000776"(kinetochore)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007051"(spindle organization)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008017"(microtubule binding)|go:"GO:0016604"(nuclear body)|go:"GO:0030496"(midbody)|go:"GO:0032388"(positive regulation of intracellular transport)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035253"(ciliary rootlet)|go:"GO:0035371"(microtubule plus-end)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051294"(establishment of spindle orientation)|go:"GO:0051301"(cell division)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090235"(regulation of metaphase plate congression)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:1905832"(positive regulation of spindle assembly)|interpro:IPR028728|mint:Q96R06|dip:DIP-30998N go:"GO:0005816"(spindle pole body) - - figure legend:Fig. 2A|comment:A minor overlap between OSBPL8 and SPAG5 was observed in the spindle pole region.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).") - 2020/03/09 2020/03/09 rogid:KwZ5DFeGTIM3p/yP3XBNgr/v3O09606 rogid:WOMksaINKpqSxqeGIzbmcSRcgdw9606 rigid:7fbPf34bnA2HqVhz4bLUrhyXDuo false - - - - psi-mi:"MI:1200"(immunocytochemistry) psi-mi:"MI:1200"(immunocytochemistry) uniprotkb:Q9BZF1 uniprotkb:Q96R06 intact:EBI-2684038|uniprotkb:Q52LQ3|uniprotkb:Q9P277|uniprotkb:Q8WXP8|uniprotkb:A8K1T2|uniprotkb:E9PE66|uniprotkb:E9PE68|uniprotkb:Q68D75|ensembl:ENSP00000261183 intact:EBI-413317|uniprotkb:O95213|uniprotkb:Q9BWE8|uniprotkb:Q9NT17|uniprotkb:Q9UFE6|intact:EBI-28972684|ensembl:ENSP00000323300 psi-mi:osbl8_human(display_long)|uniprotkb:KIAA1451(gene name synonym)|uniprotkb:ORP8(gene name synonym)|uniprotkb:OSBP10(gene name synonym)|uniprotkb:OSBPL8(gene name)|psi-mi:OSBPL8(display_short) psi-mi:spag5_human(display_long)|uniprotkb:SPAG5(gene name)|psi-mi:SPAG5(display_short)|uniprotkb:Astrin(gene name synonym)|uniprotkb:Mitotic spindle-associated protein p126(gene name synonym)|uniprotkb:Deepest(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Zhong et al. (2014) imex:IM-28061|pubmed:24424245 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0486"(UniProt) intact:EBI-25466952|imex:IM-28061-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001003712.1|refseq:NP_065892.1|refseq:NP_001306581.1|refseq:NP_001306584.1|ensembl:ENSG00000091039(gene)|ensembl:ENST00000261183(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005548"(phospholipid transporter activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010891"(negative regulation of sequestering of triglyceride)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0015914"(phospholipid transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032541"(cortical endoplasmic reticulum)|go:"GO:0032934"(sterol binding)|go:"GO:0036150"(phosphatidylserine acyl-chain remodeling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0090204"(protein localization to nuclear pore)|go:"GO:0140343"(phosphatidylserine transfer activity)|interpro:IPR000648(Oxysterol-binding protein)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018494|interpro:IPR037239|mint:Q9BZF1|rcsb pdb:1V88|rcsb pdb:5U77|rcsb pdb:5U78|reactome:R-HSA-1482801|refseq:XP_005268678.1|refseq:XP_006719287.1|dip:DIP-56130N refseq:NP_006452.3|ensembl:ENSP00000323300|ensembl:ENSG00000076382(gene)|ensembl:ENST00000321765(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000776"(kinetochore)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007051"(spindle organization)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008017"(microtubule binding)|go:"GO:0016604"(nuclear body)|go:"GO:0030496"(midbody)|go:"GO:0032388"(positive regulation of intracellular transport)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035253"(ciliary rootlet)|go:"GO:0035371"(microtubule plus-end)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051294"(establishment of spindle orientation)|go:"GO:0051301"(cell division)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090235"(regulation of metaphase plate congression)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:1905832"(positive regulation of spindle assembly)|interpro:IPR028728|mint:Q96R06|dip:DIP-30998N go:"GO:0005816"(spindle pole body) - - figure legend:Fig. 2E|comment:A minor overlap between OSBPL8 and SPAG5 was observed in the spindle pole region.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).") - 2020/03/09 2020/03/09 rogid:KwZ5DFeGTIM3p/yP3XBNgr/v3O09606 rogid:WOMksaINKpqSxqeGIzbmcSRcgdw9606 rigid:7fbPf34bnA2HqVhz4bLUrhyXDuo false - xpress tag:?-? - - psi-mi:"MI:1200"(immunocytochemistry) psi-mi:"MI:1200"(immunocytochemistry) uniprotkb:Q96R06 uniprotkb:Q9BZF1 intact:EBI-413317|uniprotkb:O95213|uniprotkb:Q9BWE8|uniprotkb:Q9NT17|uniprotkb:Q9UFE6|intact:EBI-28972684|ensembl:ENSP00000323300 intact:EBI-2684038|uniprotkb:Q52LQ3|uniprotkb:Q9P277|uniprotkb:Q8WXP8|uniprotkb:A8K1T2|uniprotkb:E9PE66|uniprotkb:E9PE68|uniprotkb:Q68D75|ensembl:ENSP00000261183 psi-mi:spag5_human(display_long)|uniprotkb:SPAG5(gene name)|psi-mi:SPAG5(display_short)|uniprotkb:Astrin(gene name synonym)|uniprotkb:Mitotic spindle-associated protein p126(gene name synonym)|uniprotkb:Deepest(gene name synonym) psi-mi:osbl8_human(display_long)|uniprotkb:KIAA1451(gene name synonym)|uniprotkb:ORP8(gene name synonym)|uniprotkb:OSBP10(gene name synonym)|uniprotkb:OSBPL8(gene name)|psi-mi:OSBPL8(display_short) psi-mi:"MI:0663"(confocal microscopy) Zhong et al. (2014) imex:IM-28061|pubmed:24424245 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0486"(UniProt) intact:EBI-25466942|imex:IM-28061-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006452.3|ensembl:ENSP00000323300|ensembl:ENSG00000076382(gene)|ensembl:ENST00000321765(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000776"(kinetochore)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007051"(spindle organization)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008017"(microtubule binding)|go:"GO:0016604"(nuclear body)|go:"GO:0030496"(midbody)|go:"GO:0032388"(positive regulation of intracellular transport)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035253"(ciliary rootlet)|go:"GO:0035371"(microtubule plus-end)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051294"(establishment of spindle orientation)|go:"GO:0051301"(cell division)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090235"(regulation of metaphase plate congression)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:1905832"(positive regulation of spindle assembly)|interpro:IPR028728|mint:Q96R06|dip:DIP-30998N refseq:NP_001003712.1|refseq:NP_065892.1|refseq:NP_001306581.1|refseq:NP_001306584.1|ensembl:ENSG00000091039(gene)|ensembl:ENST00000261183(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005548"(phospholipid transporter activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010891"(negative regulation of sequestering of triglyceride)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0015914"(phospholipid transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032541"(cortical endoplasmic reticulum)|go:"GO:0032934"(sterol binding)|go:"GO:0036150"(phosphatidylserine acyl-chain remodeling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0090204"(protein localization to nuclear pore)|go:"GO:0140343"(phosphatidylserine transfer activity)|interpro:IPR000648(Oxysterol-binding protein)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018494|interpro:IPR037239|mint:Q9BZF1|rcsb pdb:1V88|rcsb pdb:5U77|rcsb pdb:5U78|reactome:R-HSA-1482801|refseq:XP_005268678.1|refseq:XP_006719287.1|dip:DIP-56130N go:"GO:0005816"(spindle pole body) - - figure legend:Fig. 2B|comment:A minor overlap between OSBPL8 and SPAG5 was observed in the spindle pole region.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-huh7)|taxid:9606(Homo sapiens hepatoma cell line established from a hepatocellular carcinoma) - 2020/03/09 2020/03/09 rogid:WOMksaINKpqSxqeGIzbmcSRcgdw9606 rogid:KwZ5DFeGTIM3p/yP3XBNgr/v3O09606 rigid:7fbPf34bnA2HqVhz4bLUrhyXDuo false - - - - psi-mi:"MI:1200"(immunocytochemistry) psi-mi:"MI:1200"(immunocytochemistry)