#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P48788	uniprotkb:P63316	intact:EBI-7746394|ensembl:ENSP00000252898|ensembl:ENSP00000371331|ensembl:ENSP00000371336|ensembl:ENSP00000500044|ensembl:ENSP00000500698|ensembl:ENSP00000500770|uniprotkb:A6NJU5|uniprotkb:A6NIV8|intact:MINT-3016990	intact:EBI-3906339|uniprotkb:P02590|uniprotkb:P04463|uniprotkb:O14800|ensembl:ENSP00000232975	psi-mi:tnni2_human(display_long)|uniprotkb:TNNI2(gene name)|psi-mi:TNNI2(display_short)|uniprotkb:Troponin I, fast-twitch isoform(gene name synonym)	psi-mi:tnnc1_human(display_long)|uniprotkb:TNNC1(gene name)|psi-mi:TNNC1(display_short)|uniprotkb:TNNC(gene name synonym)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Robertson et al. (2014)	pubmed:24333682|imex:IM-28225	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25668736|imex:IM-28225-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139313.1|ensembl:ENSG00000130598(gene)|ensembl:ENSG00000288219(gene)|ensembl:ENST00000252898(transcript)|ensembl:ENST00000381906(transcript)|ensembl:ENST00000381911(transcript)|ensembl:ENST00000672014(transcript)|ensembl:ENST00000672632(transcript)|ensembl:ENST00000673526(transcript)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005861"(troponin complex)|go:"GO:0006936"(muscle contraction)|go:"GO:0006937"(regulation of muscle contraction)|go:"GO:0031014"(troponin T binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0060048"(cardiac muscle contraction)|interpro:IPR001978(Troponin)|interpro:IPR038077|mint:P48788|rcsb pdb:2MKP|rcsb pdb:7KAA|reactome:R-HSA-390522|refseq:NP_003273.1|refseq:NP_001139301.1	refseq:NP_003271.1|ensembl:ENSG00000114854(gene)|ensembl:ENST00000232975(transcript)|go:"GO:0002086"(diaphragm contraction)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005829"(cytosol)|go:"GO:0005861"(troponin complex)|go:"GO:0006937"(regulation of muscle contraction)|go:"GO:0010038"(response to metal ion)|go:"GO:0014883"(transition between fast and slow fiber)|go:"GO:0031013"(troponin I binding)|go:"GO:0031014"(troponin T binding)|go:"GO:0032972"(regulation of muscle filament sliding speed)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043462"(regulation of ATP-dependent activity)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:1990584"(cardiac Troponin complex)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|rcsb pdb:1AP4|rcsb pdb:1IH0|rcsb pdb:1J1D|rcsb pdb:1J1E|rcsb pdb:1LXF|rcsb pdb:1MXL|rcsb pdb:1OZS|rcsb pdb:1SPY|rcsb pdb:1WRK|rcsb pdb:1WRL|rcsb pdb:2JT0|rcsb pdb:2JT3|rcsb pdb:2JT8|rcsb pdb:2JTZ|rcsb pdb:2JXL|rcsb pdb:2KDH|rcsb pdb:2KFX|rcsb pdb:2KGB|rcsb pdb:2KRD|rcsb pdb:2L1R|rcsb pdb:2L98|rcsb pdb:2MKP|rcsb pdb:2MLE|rcsb pdb:2MLF|rcsb pdb:2MZP|rcsb pdb:2N79|rcsb pdb:2N7L|rcsb pdb:3RV5|rcsb pdb:3SD6|rcsb pdb:3SWB|rcsb pdb:4GJE|rcsb pdb:4GJF|rcsb pdb:4GJG|rcsb pdb:4Y99|rcsb pdb:5VLN|rcsb pdb:5W88|rcsb pdb:5WCL|rcsb pdb:6KN7|rcsb pdb:6KN8|rcsb pdb:6MV3|rcsb pdb:7JGI|reactome:R-HSA-390522	pdbe:2mpk	function:Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity|comment:mint|function:"Defects in TNNI2 are a cause of distal arthrogryposis type 2B (DA2B) [MIM:601680]; also known as arthrogryposis multiplex congenita, distal, type 2B (AMCD2B). DA2B is a form of inherited multiple congenital contractures. Affected individuals have vertical talus, ulnar deviation in the hands, severe camptodactyly, and a distinctive face characterized by a triangular shape, prominent nasolabial folds, small mouth and a prominent chin"	-	figure legend:Fig. 4a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/06/18	2020/06/18	rogid:Klnf5MLsOn9oudllC4XPmbkdF+89606	rogid:XsWAxSgP8gvX6F0jwWQxFk4skkU9606	rigid:SjQTelWoJAW+BqS38GGCL9bWHwI	false	sufficient binding region:116-132	sufficient binding region:1-89	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)