#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q8IBE8 uniprotkb:P02724 intact:EBI-781633|ensemblprotists:CAD51055 intact:EBI-702665|uniprotkb:Q9BS51|uniprotkb:A8K3E6|uniprotkb:B8Q182|uniprotkb:B8Q185 psi-mi:q8ibe8_plaf7(display_long)|uniprotkb:PF3D7_0731500(orf name) psi-mi:glpa_human(display_long)|uniprotkb:PAS-2(gene name synonym)|uniprotkb:Sialoglycoprotein alpha(gene name synonym)|uniprotkb:MN sialoglycoprotein(gene name synonym)|uniprotkb:GYPA(gene name)|psi-mi:GYPA(display_short)|uniprotkb:GPA(gene name synonym) psi-mi:"MI:2189"(avexis) Wanaguru et al. (2013) imex:IM-28092|pubmed:24297912 taxid:36329(plaf7)|taxid:36329("Plasmodium falciparum (isolate 3D7)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-25648071|imex:IM-28092-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR042202|interpro:IPR008602(Plasmodium Duffy binding)|interpro:IPR021620|refseq:XP_001349207.2|rcsb pdb:4K2U|interpro:IPR043057|ensemblprotists:CAD51055(transcript)|ensemblprotists:PF3D7_0731500(gene)|go:"GO:0008201"(heparin binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020009"(microneme)|go:"GO:0044409"(entry into host)|go:"GO:0046789"(host cell surface receptor binding) refseq:NP_002090.4|interpro:IPR001195(Glycophorin A and B)|interpro:IPR018938|rcsb pdb:1AFO|rcsb pdb:1MSR|rcsb pdb:2KPE|rcsb pdb:2KPF|rcsb pdb:5EH4|rcsb pdb:5EH6|refseq:NP_001295119.1|refseq:XP_016863624.1|reactome:R-HSA-202733|go:"GO:0001618"(virus receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding) - - - figure legend:1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/05/08 2020/06/16 rogid:iDsa85bICLNH3PvhbZPClDUdGlc36329 rogid:QYkwVSmE7sIqAeoopqJRWvEu1PI9606 rigid:NJsTFfub5tBqgKgi8j0xGUmtXnA false tag:c-c|tag:c-c|tag:c-c|sufficient binding region:142-764 biotin tag:c-c|carbohydrate chemical modification:?-?|tag:c-c 5 - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9N9G9 uniprotkb:P02724 intact:EBI-25648255 intact:EBI-702665|uniprotkb:Q9BS51|uniprotkb:A8K3E6|uniprotkb:B8Q182|uniprotkb:B8Q185 psi-mi:q9n9g9_plare(display_long)|uniprotkb:EBP(gene name)|psi-mi:EBP(display_short) psi-mi:glpa_human(display_long)|uniprotkb:PAS-2(gene name synonym)|uniprotkb:Sialoglycoprotein alpha(gene name synonym)|uniprotkb:MN sialoglycoprotein(gene name synonym)|uniprotkb:GYPA(gene name)|psi-mi:GYPA(display_short)|uniprotkb:GPA(gene name synonym) psi-mi:"MI:2189"(avexis) Wanaguru et al. (2013) imex:IM-28092|pubmed:24297912 taxid:5854(Plasmodium reichenowi)|taxid:5854(Plasmodium reichenowi) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-25648238|imex:IM-28092-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016021"(integral component of membrane)|go:"GO:0046789"(host cell surface receptor binding)|interpro:IPR042202|interpro:IPR008602(Plasmodium Duffy binding)|interpro:IPR021620|interpro:IPR043057 refseq:NP_002090.4|interpro:IPR001195(Glycophorin A and B)|interpro:IPR018938|rcsb pdb:1AFO|rcsb pdb:1MSR|rcsb pdb:2KPE|rcsb pdb:2KPF|rcsb pdb:5EH4|rcsb pdb:5EH6|refseq:NP_001295119.1|refseq:XP_016863624.1|reactome:R-HSA-202733|go:"GO:0001618"(virus receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding) - - - figure legend:1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/05/08 2020/06/16 rogid:zN6ECWx3KFLgIc0PkJi6FS5Jym85854 rogid:QYkwVSmE7sIqAeoopqJRWvEu1PI9606 rigid:d71vvSaq3FZHpDtad/6wA/2H608 false sufficient binding region:?-?|tag:c-c|tag:c-c|tag:c-c biotin tag:c-c|carbohydrate chemical modification:?-?|tag:c-c 5 - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:V9XTM1 uniprotkb:P02724 intact:EBI-25648284 intact:EBI-702665|uniprotkb:Q9BS51|uniprotkb:A8K3E6|uniprotkb:B8Q182|uniprotkb:B8Q185 psi-mi:v9xtm1_9apic(display_long)|uniprotkb:EBA-175(gene name)|psi-mi:EBA-175(display_short) psi-mi:glpa_human(display_long)|uniprotkb:PAS-2(gene name synonym)|uniprotkb:Sialoglycoprotein alpha(gene name synonym)|uniprotkb:MN sialoglycoprotein(gene name synonym)|uniprotkb:GYPA(gene name)|psi-mi:GYPA(display_short)|uniprotkb:GPA(gene name synonym) psi-mi:"MI:2189"(avexis) Wanaguru et al. (2013) imex:IM-28092|pubmed:24297912 taxid:880533(Plasmodium sp. chimpanzee clade C3)|taxid:880533(Plasmodium sp. chimpanzee clade C3) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-25648267|imex:IM-28092-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016021"(integral component of membrane)|go:"GO:0046789"(host cell surface receptor binding)|interpro:IPR042202|interpro:IPR008602(Plasmodium Duffy binding) refseq:NP_002090.4|interpro:IPR001195(Glycophorin A and B)|interpro:IPR018938|rcsb pdb:1AFO|rcsb pdb:1MSR|rcsb pdb:2KPE|rcsb pdb:2KPF|rcsb pdb:5EH4|rcsb pdb:5EH6|refseq:NP_001295119.1|refseq:XP_016863624.1|reactome:R-HSA-202733|go:"GO:0001618"(virus receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding) - - - figure legend:1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/05/08 2020/06/16 rogid:OWUTmdFsd3TmGIIRGljPtgeQ/H0880533 rogid:QYkwVSmE7sIqAeoopqJRWvEu1PI9606 rigid:GX7bMXz0kV6dZZ1CruKsOMpz/0Q false sufficient binding region:?-?|tag:c-c|tag:c-c|tag:c-c biotin tag:c-c|carbohydrate chemical modification:?-?|tag:c-c 5 - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P35613-2 uniprotkb:Q8IFM5 intact:EBI-11037868|ensembl:ENSP00000343809 intact:EBI-22304327|ensemblprotists:CAD49275 psi-mi:p35613-2(display_long)|uniprotkb:Short(isoform synonym)|uniprotkb:BSG(gene name)|psi-mi:BSG(display_short)|uniprotkb:5F7(gene name synonym)|uniprotkb:Collagenase stimulatory factor(gene name synonym)|uniprotkb:Extracellular matrix metalloproteinase inducer(gene name synonym)|uniprotkb:Leukocyte activation antigen M6(gene name synonym)|uniprotkb:OK blood group antigen(gene name synonym)|uniprotkb:Tumor cell-derived collagenase stimulatory factor(gene name synonym)|uniprotkb:UNQ6505/PRO21383(orf name)|uniprotkb:Hepatoma-associated antigen(gene name synonym)|uniprotkb:Basigin-2(isoform synonym) psi-mi:rh5_plaf7(display_long)|uniprotkb:RH5(gene name)|psi-mi:RH5(display_short)|uniprotkb:PFD1145c(gene name synonym)|uniprotkb:PF3D7_0424100(orf name) psi-mi:"MI:2189"(avexis) Wanaguru et al. (2013) imex:IM-28092|pubmed:24297912 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:36329(plaf7)|taxid:36329("Plasmodium falciparum (isolate 3D7)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-25648399|imex:IM-28092-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-750709(isoform-parent)|uniprotkb:P35613-2(isoform-parent)|ensembl:ENSG00000172270(gene)|ensembl:ENST00000353555(transcript) ensemblprotists:CAD49275(transcript)|ensemblprotists:PF3D7_0424100(gene)|go:"GO:0005576"(extracellular region)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0008201"(heparin binding)|go:"GO:0016020"(membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0020008"(rhoptry)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033644"(host cell membrane)|go:"GO:0034591"(rhoptry lumen)|go:"GO:0043655"(host extracellular space)|go:"GO:0044409"(entry into host)|go:"GO:0045177"(apical part of cell)|go:"GO:0046789"(host cell surface receptor binding)|refseq:XP_001351544.1|rcsb pdb:4WAT|rcsb pdb:5MI0|rcsb pdb:6MPV|rcsb pdb:6RCU|rcsb pdb:6RCV|interpro:IPR041668 - - - figure legend:2A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/05/08 2020/06/16 rogid:Ui/CkPFs2l/jofO7diENHX7vLr49606 rogid:7nMfdfdkkXUf812aMUZCX9JDkk036329 rigid:yxnAWPY6FsEUgjXPBketv0io5Fk false tag:c-c|tag:c-c|tag:c-c|sufficient binding region:1-206 biotin tag:c-c|tag:c-c 5 - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:A0A0M5L610 uniprotkb:Q8IFM5 intact:EBI-25648504 intact:EBI-22304327|ensemblprotists:CAD49275 psi-mi:a0a0m5l610_pantr(display_long)|uniprotkb:BSG(gene name)|psi-mi:BSG(display_short) psi-mi:rh5_plaf7(display_long)|uniprotkb:RH5(gene name)|psi-mi:RH5(display_short)|uniprotkb:PFD1145c(gene name synonym)|uniprotkb:PF3D7_0424100(orf name) psi-mi:"MI:2189"(avexis) Wanaguru et al. (2013) imex:IM-28092|pubmed:24297912 taxid:9598(pantr)|taxid:9598("Pan troglodytes (Chimpanzee)") taxid:36329(plaf7)|taxid:36329("Plasmodium falciparum (isolate 3D7)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-25648433|imex:IM-28092-23 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005537"(mannose binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007411"(axon guidance)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR043204|interpro:IPR044157 ensemblprotists:CAD49275(transcript)|ensemblprotists:PF3D7_0424100(gene)|go:"GO:0005576"(extracellular region)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0008201"(heparin binding)|go:"GO:0016020"(membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0020008"(rhoptry)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033644"(host cell membrane)|go:"GO:0034591"(rhoptry lumen)|go:"GO:0043655"(host extracellular space)|go:"GO:0044409"(entry into host)|go:"GO:0045177"(apical part of cell)|go:"GO:0046789"(host cell surface receptor binding)|refseq:XP_001351544.1|rcsb pdb:4WAT|rcsb pdb:5MI0|rcsb pdb:6MPV|rcsb pdb:6RCU|rcsb pdb:6RCV|interpro:IPR041668 - - - figure legend:2A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/05/08 2020/06/16 rogid:IrCblCkcVFZGPEMa5OnMxMu4I849598 rogid:7nMfdfdkkXUf812aMUZCX9JDkk036329 rigid:tNUgjw4L8lJDTsDROWfv/T4vyYM false mutation:164-164,168-168,184-184|tag:c-c|tag:c-c|tag:c-c|sufficient binding region:1-206 biotin tag:c-c|tag:c-c 5 - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:G3S3K5 uniprotkb:Q8IFM5 intact:EBI-25648549|ensembl:ENSGGOP00000022655|uniprotkb:A0A0M4NH76 intact:EBI-22304327|ensemblprotists:CAD49275 psi-mi:g3s3k5_gorgo(display_long)|uniprotkb:BSG(gene name)|psi-mi:BSG(display_short) psi-mi:rh5_plaf7(display_long)|uniprotkb:RH5(gene name)|psi-mi:RH5(display_short)|uniprotkb:PFD1145c(gene name synonym)|uniprotkb:PF3D7_0424100(orf name) psi-mi:"MI:2189"(avexis) Wanaguru et al. (2013) imex:IM-28092|pubmed:24297912 taxid:9595(Western lowland gorilla)|taxid:9595(Gorilla gorilla gorilla) taxid:36329(plaf7)|taxid:36329("Plasmodium falciparum (isolate 3D7)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-25648528|imex:IM-28092-13 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSGGOG00000006872(gene)|ensembl:ENSGGOT00000028132(transcript)|go:"GO:0005537"(mannose binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007411"(axon guidance)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR043204|interpro:IPR044157 ensemblprotists:CAD49275(transcript)|ensemblprotists:PF3D7_0424100(gene)|go:"GO:0005576"(extracellular region)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0008201"(heparin binding)|go:"GO:0016020"(membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0020008"(rhoptry)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033644"(host cell membrane)|go:"GO:0034591"(rhoptry lumen)|go:"GO:0043655"(host extracellular space)|go:"GO:0044409"(entry into host)|go:"GO:0045177"(apical part of cell)|go:"GO:0046789"(host cell surface receptor binding)|refseq:XP_001351544.1|rcsb pdb:4WAT|rcsb pdb:5MI0|rcsb pdb:6MPV|rcsb pdb:6RCU|rcsb pdb:6RCV|interpro:IPR041668 - - - figure legend:2A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/05/08 2020/06/16 rogid:Oa1nMF85lTfaJK+Qt7Me/B8mSC89595 rogid:7nMfdfdkkXUf812aMUZCX9JDkk036329 rigid:U8tIeJTA5UzcJTuSpzIHb0jTw+0 false mutation:100-100|tag:c-c|tag:c-c|tag:c-c|sufficient binding region:1-207 biotin tag:c-c|tag:c-c 5 - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8IFM5 uniprotkb:A0A0M5L610 intact:EBI-22304327|ensemblprotists:CAD49275 intact:EBI-25648504 psi-mi:rh5_plaf7(display_long)|uniprotkb:RH5(gene name)|psi-mi:RH5(display_short)|uniprotkb:PFD1145c(gene name synonym)|uniprotkb:PF3D7_0424100(orf name) psi-mi:a0a0m5l610_pantr(display_long)|uniprotkb:BSG(gene name)|psi-mi:BSG(display_short) psi-mi:"MI:2189"(avexis) Wanaguru et al. (2013) imex:IM-28092|pubmed:24297912 taxid:36329(plaf7)|taxid:36329("Plasmodium falciparum (isolate 3D7)") taxid:9598(pantr)|taxid:9598("Pan troglodytes (Chimpanzee)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-25648886|imex:IM-28092-15 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblprotists:CAD49275(transcript)|ensemblprotists:PF3D7_0424100(gene)|go:"GO:0005576"(extracellular region)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0008201"(heparin binding)|go:"GO:0016020"(membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0020008"(rhoptry)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033644"(host cell membrane)|go:"GO:0034591"(rhoptry lumen)|go:"GO:0043655"(host extracellular space)|go:"GO:0044409"(entry into host)|go:"GO:0045177"(apical part of cell)|go:"GO:0046789"(host cell surface receptor binding)|refseq:XP_001351544.1|rcsb pdb:4WAT|rcsb pdb:5MI0|rcsb pdb:6MPV|rcsb pdb:6RCU|rcsb pdb:6RCV|interpro:IPR041668 go:"GO:0005537"(mannose binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007411"(axon guidance)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR043204|interpro:IPR044157 - - - figure legend:3A|comment:"The mutations P164Q, and L184R also had no effect on the interaction. The mutation \"G145E\" has been entered as \"G146E\" as there is no \"G\" at position 145."|caution:"The sequence used here for chimpanzee (PtBSG), Ensembl ENSPTRP00000017252, is \"retired\" - \"This transcript is not in the current gene set.\". Trembl entry A0A0M5L610 is the nearest match with >98% identity. The \"mutations of no effect\" P164Q, and L184R cannot be entered as there is already a Q and R residue in the current sequence A0A0M5L610."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/05/08 2020/06/17 rogid:7nMfdfdkkXUf812aMUZCX9JDkk036329 rogid:IrCblCkcVFZGPEMa5OnMxMu4I849598 rigid:tNUgjw4L8lJDTsDROWfv/T4vyYM false tag:c-c|tag:c-c|tag:c-c mutation with no effect:123-123|mutation with no effect:163-163|sufficient binding region:1-206|biotin tag:c-c|tag:c-c|mutation causing an interaction:191-191|mutation with no effect:188-188|mutation with no effect:197-197|mutation with no effect:146-146|mutation with no effect:168-168 5 - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8IFM5 uniprotkb:P35613-2 intact:EBI-22304327|ensemblprotists:CAD49275 intact:EBI-11037868|ensembl:ENSP00000343809 psi-mi:rh5_plaf7(display_long)|uniprotkb:RH5(gene name)|psi-mi:RH5(display_short)|uniprotkb:PFD1145c(gene name synonym)|uniprotkb:PF3D7_0424100(orf name) psi-mi:p35613-2(display_long)|uniprotkb:Short(isoform synonym)|uniprotkb:BSG(gene name)|psi-mi:BSG(display_short)|uniprotkb:5F7(gene name synonym)|uniprotkb:Collagenase stimulatory factor(gene name synonym)|uniprotkb:Extracellular matrix metalloproteinase inducer(gene name synonym)|uniprotkb:Leukocyte activation antigen M6(gene name synonym)|uniprotkb:OK blood group antigen(gene name synonym)|uniprotkb:Tumor cell-derived collagenase stimulatory factor(gene name synonym)|uniprotkb:UNQ6505/PRO21383(orf name)|uniprotkb:Hepatoma-associated antigen(gene name synonym)|uniprotkb:Basigin-2(isoform synonym) psi-mi:"MI:2189"(avexis) Wanaguru et al. (2013) imex:IM-28092|pubmed:24297912 taxid:36329(plaf7)|taxid:36329("Plasmodium falciparum (isolate 3D7)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-25648949|imex:IM-28092-17 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblprotists:CAD49275(transcript)|ensemblprotists:PF3D7_0424100(gene)|go:"GO:0005576"(extracellular region)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0008201"(heparin binding)|go:"GO:0016020"(membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0020008"(rhoptry)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033644"(host cell membrane)|go:"GO:0034591"(rhoptry lumen)|go:"GO:0043655"(host extracellular space)|go:"GO:0044409"(entry into host)|go:"GO:0045177"(apical part of cell)|go:"GO:0046789"(host cell surface receptor binding)|refseq:XP_001351544.1|rcsb pdb:4WAT|rcsb pdb:5MI0|rcsb pdb:6MPV|rcsb pdb:6RCU|rcsb pdb:6RCV|interpro:IPR041668 intact:EBI-750709(isoform-parent)|uniprotkb:P35613-2(isoform-parent)|ensembl:ENSG00000172270(gene)|ensembl:ENST00000353555(transcript) - - - figure legend:3C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/05/08 2020/06/17 rogid:7nMfdfdkkXUf812aMUZCX9JDkk036329 rogid:Ui/CkPFs2l/jofO7diENHX7vLr49606 rigid:yxnAWPY6FsEUgjXPBketv0io5Fk false tag:c-c|tag:c-c|tag:c-c sufficient binding region:1-206|mutation decreasing interaction strength:27-27|mutation with no effect:32-32|mutation with no effect:75-75|biotin tag:c-c|tag:c-c|mutation decreasing interaction strength:100-100|mutation decreasing interaction strength:102-103 5 - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:V9XTM1 uniprotkb:P02724 intact:EBI-25648284 intact:EBI-702665|uniprotkb:Q9BS51|uniprotkb:A8K3E6|uniprotkb:B8Q182|uniprotkb:B8Q185 psi-mi:v9xtm1_9apic(display_long)|uniprotkb:EBA-175(gene name)|psi-mi:EBA-175(display_short) psi-mi:glpa_human(display_long)|uniprotkb:PAS-2(gene name synonym)|uniprotkb:Sialoglycoprotein alpha(gene name synonym)|uniprotkb:MN sialoglycoprotein(gene name synonym)|uniprotkb:GYPA(gene name)|psi-mi:GYPA(display_short)|uniprotkb:GPA(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) Wanaguru et al. (2013) imex:IM-28092|pubmed:24297912 taxid:880533(Plasmodium sp. chimpanzee clade C3)|taxid:880533(Plasmodium sp. chimpanzee clade C3) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-25648356|imex:IM-28092-21 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016021"(integral component of membrane)|go:"GO:0046789"(host cell surface receptor binding)|interpro:IPR042202|interpro:IPR008602(Plasmodium Duffy binding) refseq:NP_002090.4|interpro:IPR001195(Glycophorin A and B)|interpro:IPR018938|rcsb pdb:1AFO|rcsb pdb:1MSR|rcsb pdb:2KPE|rcsb pdb:2KPF|rcsb pdb:5EH4|rcsb pdb:5EH6|refseq:NP_001295119.1|refseq:XP_016863624.1|reactome:R-HSA-202733|go:"GO:0001618"(virus receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding) - - - figure legend:1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:6.0x10^-6(molar) 2020/05/08 2020/06/16 rogid:OWUTmdFsd3TmGIIRGljPtgeQ/H0880533 rogid:QYkwVSmE7sIqAeoopqJRWvEu1PI9606 rigid:GX7bMXz0kV6dZZ1CruKsOMpz/0Q false sufficient binding region:?-?|his tag:c-c|tag:c-c biotin tag:c-c|tag:c-c 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9N9G9 uniprotkb:P02724 intact:EBI-25648255 intact:EBI-702665|uniprotkb:Q9BS51|uniprotkb:A8K3E6|uniprotkb:B8Q182|uniprotkb:B8Q185 psi-mi:q9n9g9_plare(display_long)|uniprotkb:EBP(gene name)|psi-mi:EBP(display_short) psi-mi:glpa_human(display_long)|uniprotkb:PAS-2(gene name synonym)|uniprotkb:Sialoglycoprotein alpha(gene name synonym)|uniprotkb:MN sialoglycoprotein(gene name synonym)|uniprotkb:GYPA(gene name)|psi-mi:GYPA(display_short)|uniprotkb:GPA(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) Wanaguru et al. (2013) imex:IM-28092|pubmed:24297912 taxid:5854(Plasmodium reichenowi)|taxid:5854(Plasmodium reichenowi) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-25648338|imex:IM-28092-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016021"(integral component of membrane)|go:"GO:0046789"(host cell surface receptor binding)|interpro:IPR042202|interpro:IPR008602(Plasmodium Duffy binding)|interpro:IPR021620|interpro:IPR043057 refseq:NP_002090.4|interpro:IPR001195(Glycophorin A and B)|interpro:IPR018938|rcsb pdb:1AFO|rcsb pdb:1MSR|rcsb pdb:2KPE|rcsb pdb:2KPF|rcsb pdb:5EH4|rcsb pdb:5EH6|refseq:NP_001295119.1|refseq:XP_016863624.1|reactome:R-HSA-202733|go:"GO:0001618"(virus receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding) - - - figure legend:1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:5.7x10^-6(molar) 2020/05/08 2020/06/16 rogid:zN6ECWx3KFLgIc0PkJi6FS5Jym85854 rogid:QYkwVSmE7sIqAeoopqJRWvEu1PI9606 rigid:d71vvSaq3FZHpDtad/6wA/2H608 false sufficient binding region:?-?|his tag:c-c|tag:c-c biotin tag:c-c|tag:c-c 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8IBE8 uniprotkb:P02724 intact:EBI-781633|ensemblprotists:CAD51055 intact:EBI-702665|uniprotkb:Q9BS51|uniprotkb:A8K3E6|uniprotkb:B8Q182|uniprotkb:B8Q185 psi-mi:q8ibe8_plaf7(display_long)|uniprotkb:PF3D7_0731500(orf name) psi-mi:glpa_human(display_long)|uniprotkb:PAS-2(gene name synonym)|uniprotkb:Sialoglycoprotein alpha(gene name synonym)|uniprotkb:MN sialoglycoprotein(gene name synonym)|uniprotkb:GYPA(gene name)|psi-mi:GYPA(display_short)|uniprotkb:GPA(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) Wanaguru et al. (2013) imex:IM-28092|pubmed:24297912 taxid:36329(plaf7)|taxid:36329("Plasmodium falciparum (isolate 3D7)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-25648374|imex:IM-28092-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR042202|interpro:IPR008602(Plasmodium Duffy binding)|interpro:IPR021620|refseq:XP_001349207.2|rcsb pdb:4K2U|interpro:IPR043057|ensemblprotists:CAD51055(transcript)|ensemblprotists:PF3D7_0731500(gene)|go:"GO:0008201"(heparin binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020009"(microneme)|go:"GO:0044409"(entry into host)|go:"GO:0046789"(host cell surface receptor binding) refseq:NP_002090.4|interpro:IPR001195(Glycophorin A and B)|interpro:IPR018938|rcsb pdb:1AFO|rcsb pdb:1MSR|rcsb pdb:2KPE|rcsb pdb:2KPF|rcsb pdb:5EH4|rcsb pdb:5EH6|refseq:NP_001295119.1|refseq:XP_016863624.1|reactome:R-HSA-202733|go:"GO:0001618"(virus receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding) - - - figure legend:1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:2.5x10^-6(molar) 2020/05/08 2020/06/16 rogid:iDsa85bICLNH3PvhbZPClDUdGlc36329 rogid:QYkwVSmE7sIqAeoopqJRWvEu1PI9606 rigid:NJsTFfub5tBqgKgi8j0xGUmtXnA false his tag:c-c|tag:c-c|sufficient binding region:142-764 biotin tag:c-c|tag:c-c 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:A0A0M5L610 uniprotkb:Q8IFM5 intact:EBI-25648504 intact:EBI-22304327|ensemblprotists:CAD49275 psi-mi:a0a0m5l610_pantr(display_long)|uniprotkb:BSG(gene name)|psi-mi:BSG(display_short) psi-mi:rh5_plaf7(display_long)|uniprotkb:RH5(gene name)|psi-mi:RH5(display_short)|uniprotkb:PFD1145c(gene name synonym)|uniprotkb:PF3D7_0424100(orf name) psi-mi:"MI:0107"(surface plasmon resonance) Wanaguru et al. (2013) imex:IM-28092|pubmed:24297912 taxid:9598(pantr)|taxid:9598("Pan troglodytes (Chimpanzee)") taxid:36329(plaf7)|taxid:36329("Plasmodium falciparum (isolate 3D7)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-25648595|imex:IM-28092-25 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005537"(mannose binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007411"(axon guidance)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR043204|interpro:IPR044157 ensemblprotists:CAD49275(transcript)|ensemblprotists:PF3D7_0424100(gene)|go:"GO:0005576"(extracellular region)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0008201"(heparin binding)|go:"GO:0016020"(membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0020008"(rhoptry)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033644"(host cell membrane)|go:"GO:0034591"(rhoptry lumen)|go:"GO:0043655"(host extracellular space)|go:"GO:0044409"(entry into host)|go:"GO:0045177"(apical part of cell)|go:"GO:0046789"(host cell surface receptor binding)|refseq:XP_001351544.1|rcsb pdb:4WAT|rcsb pdb:5MI0|rcsb pdb:6MPV|rcsb pdb:6RCU|rcsb pdb:6RCV|interpro:IPR041668 - - - figure legend:2B, Supp. Fig. 5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:10.4x10^-6(molar) 2020/05/08 2020/06/16 rogid:IrCblCkcVFZGPEMa5OnMxMu4I849598 rogid:7nMfdfdkkXUf812aMUZCX9JDkk036329 rigid:tNUgjw4L8lJDTsDROWfv/T4vyYM false biotin tag:c-c|tag:c-c|sufficient binding region:1-206|mutation:168-168,164-164,184-184 his tag:c-c|tag:c-c - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8IFM5 uniprotkb:P35613-2 intact:EBI-22304327|ensemblprotists:CAD49275 intact:EBI-11037868|ensembl:ENSP00000343809 psi-mi:rh5_plaf7(display_long)|uniprotkb:RH5(gene name)|psi-mi:RH5(display_short)|uniprotkb:PFD1145c(gene name synonym)|uniprotkb:PF3D7_0424100(orf name) psi-mi:p35613-2(display_long)|uniprotkb:Short(isoform synonym)|uniprotkb:BSG(gene name)|psi-mi:BSG(display_short)|uniprotkb:5F7(gene name synonym)|uniprotkb:Collagenase stimulatory factor(gene name synonym)|uniprotkb:Extracellular matrix metalloproteinase inducer(gene name synonym)|uniprotkb:Leukocyte activation antigen M6(gene name synonym)|uniprotkb:OK blood group antigen(gene name synonym)|uniprotkb:Tumor cell-derived collagenase stimulatory factor(gene name synonym)|uniprotkb:UNQ6505/PRO21383(orf name)|uniprotkb:Hepatoma-associated antigen(gene name synonym)|uniprotkb:Basigin-2(isoform synonym) psi-mi:"MI:0107"(surface plasmon resonance) Wanaguru et al. (2013) imex:IM-28092|pubmed:24297912 taxid:36329(plaf7)|taxid:36329("Plasmodium falciparum (isolate 3D7)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-25649007|imex:IM-28092-19 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblprotists:CAD49275(transcript)|ensemblprotists:PF3D7_0424100(gene)|go:"GO:0005576"(extracellular region)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0008201"(heparin binding)|go:"GO:0016020"(membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0020008"(rhoptry)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033644"(host cell membrane)|go:"GO:0034591"(rhoptry lumen)|go:"GO:0043655"(host extracellular space)|go:"GO:0044409"(entry into host)|go:"GO:0045177"(apical part of cell)|go:"GO:0046789"(host cell surface receptor binding)|refseq:XP_001351544.1|rcsb pdb:4WAT|rcsb pdb:5MI0|rcsb pdb:6MPV|rcsb pdb:6RCU|rcsb pdb:6RCV|interpro:IPR041668 intact:EBI-750709(isoform-parent)|uniprotkb:P35613-2(isoform-parent)|ensembl:ENSG00000172270(gene)|ensembl:ENST00000353555(transcript) - - - figure legend:2B, 3D, Supp. fig. 5|comment:"The affinities of the mutants F27L, Q100K, and +H103 for PfRH5 were lower than that of human BSG by approximately eightfold,11-fold, and 10-fold, respectively (Fig. 3D)."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:0.8x10^-6(molar) 2020/05/08 2020/06/17 rogid:7nMfdfdkkXUf812aMUZCX9JDkk036329 rogid:Ui/CkPFs2l/jofO7diENHX7vLr49606 rigid:yxnAWPY6FsEUgjXPBketv0io5Fk false tag:c-c|tag:c-c|tag:c-c sufficient binding region:1-206|mutation decreasing interaction strength:27-27|biotin tag:c-c|tag:c-c|mutation decreasing interaction strength:100-100|mutation decreasing interaction strength:102-103 5 - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)