#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P19711 uniprotkb:P19711 intact:EBI-9350498 intact:EBI-9350498 psi-mi:polg_bvdvn(display_long) psi-mi:polg_bvdvn(display_long) psi-mi:"MI:0114"(x-ray crystallography) Li et al. (2013) imex:IM-28497|pubmed:23569276 taxid:11100(bvdvn)|taxid:11100("Bovine viral diarrhea virus (isolate NADL)") taxid:11100(bvdvn)|taxid:11100("Bovine viral diarrhea virus (isolate NADL)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-25777343|wwpdb:4JNT|imex:IM-28497-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:5GVU|interpro:IPR030399|interpro:IPR033130|interpro:IPR032521|refseq:NP_040937.1|interpro:IPR021824|interpro:IPR011492(DEAD box, Flavivirus)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR027417|interpro:IPR022120|interpro:IPR008751(Peptidase C53, pestivirus Npro)|interpro:IPR000280(Peptidase S31, pestivurus polyprotein NS3/p80)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR002166(RNA dependent RNA polymerase, hepatitis C virus)|rcsb pdb:1S48|rcsb pdb:1S49|rcsb pdb:1S4F|rcsb pdb:4ILD|rcsb pdb:4JNT|interpro:IPR032843|interpro:IPR036430|rcsb pdb:5WSO|interpro:IPR042309|interpro:IPR042310|interpro:IPR042311|interpro:IPR042542|interpro:IPR043502|interpro:IPR043128|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019082"(viral protein processing)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0033897"(ribonuclease T2 activity)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039548"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043489"(RNA stabilization)|go:"GO:0044161"(host cell cytoplasmic vesicle)|go:"GO:0044177"(host cell Golgi apparatus)|go:"GO:0044228"(host cell surface)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0055036"(virion membrane)|go:"GO:0070008"(serine-type exopeptidase activity)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990814"(DNA/DNA annealing activity)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:0016021"(integral component of membrane) rcsb pdb:5GVU|interpro:IPR030399|interpro:IPR033130|interpro:IPR032521|refseq:NP_040937.1|interpro:IPR021824|interpro:IPR011492(DEAD box, Flavivirus)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR027417|interpro:IPR022120|interpro:IPR008751(Peptidase C53, pestivirus Npro)|interpro:IPR000280(Peptidase S31, pestivurus polyprotein NS3/p80)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR002166(RNA dependent RNA polymerase, hepatitis C virus)|rcsb pdb:1S48|rcsb pdb:1S49|rcsb pdb:1S4F|rcsb pdb:4ILD|rcsb pdb:4JNT|interpro:IPR032843|interpro:IPR036430|rcsb pdb:5WSO|interpro:IPR042309|interpro:IPR042310|interpro:IPR042311|interpro:IPR042542|interpro:IPR043502|interpro:IPR043128|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019082"(viral protein processing)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0033897"(ribonuclease T2 activity)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039548"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043489"(RNA stabilization)|go:"GO:0044161"(host cell cytoplasmic vesicle)|go:"GO:0044177"(host cell Golgi apparatus)|go:"GO:0044228"(host cell surface)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0055036"(virion membrane)|go:"GO:0070008"(serine-type exopeptidase activity)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990814"(DNA/DNA annealing activity)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:0016021"(integral component of membrane) - - - figure legend:Fig 1, Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7108(spofr-sf_9)|taxid:7108(Spodoptera frugiperda insect cells) - 2020/08/14 2020/08/14 rogid:/LMBqV3d4KvB39WGcTDo7YnJM3w11100 rogid:/LMBqV3d4KvB39WGcTDo7YnJM3w11100 rigid:shCq1FoY/NlESkjUCOmSgpxE808 false binding-associated region:693-1030|mutation:788-788 binding-associated region:693-1030|mutation:788-788 2 0 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P19711 uniprotkb:P19711 intact:EBI-9350498 intact:EBI-9350498 psi-mi:polg_bvdvn(display_long) psi-mi:polg_bvdvn(display_long) psi-mi:"MI:0071"(molecular sieving) Li et al. (2013) imex:IM-28497|pubmed:23569276 taxid:11100(bvdvn)|taxid:11100("Bovine viral diarrhea virus (isolate NADL)") taxid:11100(bvdvn)|taxid:11100("Bovine viral diarrhea virus (isolate NADL)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-25777365|imex:IM-28497-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:5GVU|interpro:IPR030399|interpro:IPR033130|interpro:IPR032521|refseq:NP_040937.1|interpro:IPR021824|interpro:IPR011492(DEAD box, Flavivirus)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR027417|interpro:IPR022120|interpro:IPR008751(Peptidase C53, pestivirus Npro)|interpro:IPR000280(Peptidase S31, pestivurus polyprotein NS3/p80)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR002166(RNA dependent RNA polymerase, hepatitis C virus)|rcsb pdb:1S48|rcsb pdb:1S49|rcsb pdb:1S4F|rcsb pdb:4ILD|rcsb pdb:4JNT|interpro:IPR032843|interpro:IPR036430|rcsb pdb:5WSO|interpro:IPR042309|interpro:IPR042310|interpro:IPR042311|interpro:IPR042542|interpro:IPR043502|interpro:IPR043128|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019082"(viral protein processing)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0033897"(ribonuclease T2 activity)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039548"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043489"(RNA stabilization)|go:"GO:0044161"(host cell cytoplasmic vesicle)|go:"GO:0044177"(host cell Golgi apparatus)|go:"GO:0044228"(host cell surface)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0055036"(virion membrane)|go:"GO:0070008"(serine-type exopeptidase activity)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990814"(DNA/DNA annealing activity)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:0016021"(integral component of membrane) rcsb pdb:5GVU|interpro:IPR030399|interpro:IPR033130|interpro:IPR032521|refseq:NP_040937.1|interpro:IPR021824|interpro:IPR011492(DEAD box, Flavivirus)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR027417|interpro:IPR022120|interpro:IPR008751(Peptidase C53, pestivirus Npro)|interpro:IPR000280(Peptidase S31, pestivurus polyprotein NS3/p80)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR002166(RNA dependent RNA polymerase, hepatitis C virus)|rcsb pdb:1S48|rcsb pdb:1S49|rcsb pdb:1S4F|rcsb pdb:4ILD|rcsb pdb:4JNT|interpro:IPR032843|interpro:IPR036430|rcsb pdb:5WSO|interpro:IPR042309|interpro:IPR042310|interpro:IPR042311|interpro:IPR042542|interpro:IPR043502|interpro:IPR043128|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019082"(viral protein processing)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0033897"(ribonuclease T2 activity)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039548"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043489"(RNA stabilization)|go:"GO:0044161"(host cell cytoplasmic vesicle)|go:"GO:0044177"(host cell Golgi apparatus)|go:"GO:0044228"(host cell surface)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0055036"(virion membrane)|go:"GO:0070008"(serine-type exopeptidase activity)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990814"(DNA/DNA annealing activity)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:0016021"(integral component of membrane) - - - figure legend:Fig S2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7108(spofr-sf_9)|taxid:7108(Spodoptera frugiperda insect cells) - 2020/08/14 2020/11/16 rogid:/LMBqV3d4KvB39WGcTDo7YnJM3w11100 rogid:/LMBqV3d4KvB39WGcTDo7YnJM3w11100 rigid:shCq1FoY/NlESkjUCOmSgpxE808 false binding-associated region:693-1030 binding-associated region:693-1030 2 0 psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:P19711 uniprotkb:P19711 intact:EBI-9350498 intact:EBI-9350498 psi-mi:polg_bvdvn(display_long) psi-mi:polg_bvdvn(display_long) psi-mi:"MI:0114"(x-ray crystallography) Li et al. (2013) imex:IM-28497|pubmed:23569276 taxid:11100(bvdvn)|taxid:11100("Bovine viral diarrhea virus (isolate NADL)") taxid:11100(bvdvn)|taxid:11100("Bovine viral diarrhea virus (isolate NADL)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-26447531|imex:IM-28497-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:5GVU|interpro:IPR030399|interpro:IPR033130|interpro:IPR032521|refseq:NP_040937.1|interpro:IPR021824|interpro:IPR011492(DEAD box, Flavivirus)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR027417|interpro:IPR022120|interpro:IPR008751(Peptidase C53, pestivirus Npro)|interpro:IPR000280(Peptidase S31, pestivurus polyprotein NS3/p80)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR002166(RNA dependent RNA polymerase, hepatitis C virus)|rcsb pdb:1S48|rcsb pdb:1S49|rcsb pdb:1S4F|rcsb pdb:4ILD|rcsb pdb:4JNT|interpro:IPR032843|interpro:IPR036430|rcsb pdb:5WSO|interpro:IPR042309|interpro:IPR042310|interpro:IPR042311|interpro:IPR042542|interpro:IPR043502|interpro:IPR043128|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019082"(viral protein processing)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0033897"(ribonuclease T2 activity)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039548"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043489"(RNA stabilization)|go:"GO:0044161"(host cell cytoplasmic vesicle)|go:"GO:0044177"(host cell Golgi apparatus)|go:"GO:0044228"(host cell surface)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0055036"(virion membrane)|go:"GO:0070008"(serine-type exopeptidase activity)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990814"(DNA/DNA annealing activity)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:0016021"(integral component of membrane) rcsb pdb:5GVU|interpro:IPR030399|interpro:IPR033130|interpro:IPR032521|refseq:NP_040937.1|interpro:IPR021824|interpro:IPR011492(DEAD box, Flavivirus)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR027417|interpro:IPR022120|interpro:IPR008751(Peptidase C53, pestivirus Npro)|interpro:IPR000280(Peptidase S31, pestivurus polyprotein NS3/p80)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR002166(RNA dependent RNA polymerase, hepatitis C virus)|rcsb pdb:1S48|rcsb pdb:1S49|rcsb pdb:1S4F|rcsb pdb:4ILD|rcsb pdb:4JNT|interpro:IPR032843|interpro:IPR036430|rcsb pdb:5WSO|interpro:IPR042309|interpro:IPR042310|interpro:IPR042311|interpro:IPR042542|interpro:IPR043502|interpro:IPR043128|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019082"(viral protein processing)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0033897"(ribonuclease T2 activity)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039548"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043489"(RNA stabilization)|go:"GO:0044161"(host cell cytoplasmic vesicle)|go:"GO:0044177"(host cell Golgi apparatus)|go:"GO:0044228"(host cell surface)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0055036"(virion membrane)|go:"GO:0070008"(serine-type exopeptidase activity)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990814"(DNA/DNA annealing activity)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:0016021"(integral component of membrane) - - - figure legend:Fig 1, Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7111(trini-high_5)|taxid:7111(Trichoplusia ni cell line from eggs) - 2020/08/14 2020/11/16 rogid:/LMBqV3d4KvB39WGcTDo7YnJM3w11100 rogid:/LMBqV3d4KvB39WGcTDo7YnJM3w11100 rigid:shCq1FoY/NlESkjUCOmSgpxE808 false binding-associated region:783-1030 binding-associated region:783-1030 2 0 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)