#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P11226	uniprotkb:P17927	intact:EBI-5325353|ensembl:ENSP00000363079|ensembl:ENSP00000502615|ensembl:ENSP00000502789|uniprotkb:Q4VB12|uniprotkb:Q4VB13|uniprotkb:Q86SI4|uniprotkb:Q96KE4|uniprotkb:Q96TF7|uniprotkb:Q96TF8|uniprotkb:Q96TF9|uniprotkb:Q4VB14|uniprotkb:Q5SQS3	intact:EBI-2807625|ensembl:ENSP00000356018|ensembl:ENSP00000356020|ensembl:ENSP00000383744|uniprotkb:Q5SR43|uniprotkb:Q9UQV2|uniprotkb:Q5SR45|uniprotkb:Q16745|uniprotkb:Q16744	psi-mi:mbl2_human(display_long)|uniprotkb:MBL2(gene name)|psi-mi:MBL2(display_short)|uniprotkb:COLEC1(gene name synonym)|uniprotkb:MBL(gene name synonym)|uniprotkb:Collectin-1(gene name synonym)|uniprotkb:MBP1(gene name synonym)|uniprotkb:Mannan-binding protein(gene name synonym)|uniprotkb:Mannose-binding lectin(gene name synonym)	psi-mi:cr1_human(display_long)|uniprotkb:CR1(gene name)|psi-mi:CR1(display_short)|uniprotkb:C3BR(gene name synonym)|uniprotkb:C3b/C4b receptor(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Jacquet et al. (2013)	imex:IM-29091|pubmed:23460739	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27034273|imex:IM-29091-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000165471(gene)|ensembl:ENST00000373968(transcript)|ensembl:ENST00000674931(transcript)|ensembl:ENST00000675947(transcript)|go:"GO:0001867"(complement activation, lectin pathway)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005537"(mannose binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0006953"(acute-phase response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008228"(opsonization)|go:"GO:0009986"(cell surface)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048525"(negative regulation of viral process)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR001304(C-type lectin)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR016186(C-type lectin-like)|refseq:XP_011538118.1|interpro:IPR018378|interpro:IPR033990|interpro:IPR037570|rcsb pdb:1HUP|interpro:IPR016187(C-type lectin fold)|reactome:R-HSA-166662|reactome:R-HSA-166663|refseq:NP_000233.1|refseq:XP_006717924.1|dip:DIP-61381N	ensembl:ENSG00000203710(gene)|go:"GO:0001855"(complement component C4b binding)|go:"GO:0001861"(complement component C4b receptor activity)|go:"GO:0001970"(positive regulation of activation of membrane attack complex)|go:"GO:0001971"(negative regulation of activation of membrane attack complex)|go:"GO:0002430"(complement receptor mediated signaling pathway)|go:"GO:0002435"(immune complex clearance by erythrocytes)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0004877"(complement component C3b receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005856"(cytoskeleton)|ensembl:ENST00000367051(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|ensembl:ENST00000367053(transcript)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0006958"(complement activation, classical pathway)|ensembl:ENST00000400960(transcript)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0001618"(virus receptor activity)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0001851"(complement component C3b binding)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045916"(negative regulation of complement activation)|go:"GO:0045918"(negative regulation of cytolysis)|go:"GO:0045957"(negative regulation of complement activation, alternative pathway)|go:"GO:0045959"(negative regulation of complement activation, classical pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:1900004"(negative regulation of serine-type endopeptidase activity)|go:"GO:1900005"(positive regulation of serine-type endopeptidase activity)|go:"GO:1900099"(negative regulation of plasma cell differentiation)|go:"GO:1904669"(ATP export)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|rcsb pdb:1GKG|rcsb pdb:1GKN|rcsb pdb:1GOP|rcsb pdb:1PPQ|rcsb pdb:2MCY|rcsb pdb:2MCZ|rcsb pdb:2Q7Z|reactome:R-HSA-6798695|reactome:R-HSA-8877330|reactome:R-HSA-977606|rcsb pdb:5FO9|refseq:NP_000564.2|refseq:NP_000642.3	-	-	-	figure legend:2A, 3A, 4A, 5A.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:0.76x10^-9(molar)	2020/12/18	2021/07/15	rogid:uo0RM88uw3otObIVnOhUcOfW8yo9606	rogid:gwNvQZmPMP1PCX8z/svSxkVBZt49606	rigid:lTfTcf19ABoAM9EFegN6riIXxFA	false	mutation disrupting interaction strength:75-75|mutation disrupting interaction strength:75-75	his tag:c-c|mutation:1208-1208|sufficient binding region:42-1971	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15485	uniprotkb:P17927	intact:EBI-7468784|uniprotkb:A6NFG7|uniprotkb:Q9UC57|uniprotkb:Q6IS69|intact:MINT-5223224|uniprotkb:Q7M4P4|uniprotkb:A8K478|ensembl:ENSP00000291744	intact:EBI-2807625|ensembl:ENSP00000356018|ensembl:ENSP00000356020|ensembl:ENSP00000383744|uniprotkb:Q5SR43|uniprotkb:Q9UQV2|uniprotkb:Q5SR45|uniprotkb:Q16745|uniprotkb:Q16744	psi-mi:fcn2_human(display_long)|uniprotkb:FCN2(gene name)|psi-mi:FCN2(display_short)|uniprotkb:FCNL(gene name synonym)|uniprotkb:Ficolin-B(gene name synonym)|uniprotkb:Ficolin-beta(gene name synonym)|uniprotkb:L-ficolin(gene name synonym)|uniprotkb:Collagen/fibrinogen domain-containing protein 2(gene name synonym)|uniprotkb:Serum lectin p35(gene name synonym)|uniprotkb:37 kDa elastin-binding protein(gene name synonym)|uniprotkb:EBP-37(gene name synonym)|uniprotkb:Hucolin(gene name synonym)	psi-mi:cr1_human(display_long)|uniprotkb:CR1(gene name)|psi-mi:CR1(display_short)|uniprotkb:C3BR(gene name synonym)|uniprotkb:C3b/C4b receptor(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Jacquet et al. (2013)	imex:IM-29091|pubmed:23460739	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27034283|imex:IM-29091-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004099.2|refseq:NP_056652.1|ensembl:ENSG00000160339(gene)|ensembl:ENST00000291744(transcript)|go:"GO:0001867"(complement activation, lectin pathway)|go:"GO:0003823"(antigen binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0008228"(opsonization)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0043654"(recognition of apoptotic cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0097367"(carbohydrate derivative binding)|go:"GO:2001065"(mannan binding)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|interpro:IPR036056|mint:Q15485|rcsb pdb:2J0G|rcsb pdb:2J0H|rcsb pdb:2J0Y|rcsb pdb:2J1G|rcsb pdb:2J2P|rcsb pdb:2J3F|rcsb pdb:2J3G|rcsb pdb:2J3O|rcsb pdb:2J3U|rcsb pdb:2J61|rcsb pdb:4NYT|rcsb pdb:4R9J|rcsb pdb:4R9T|reactome:R-HSA-166662|reactome:R-HSA-166663|reactome:R-HSA-2855086	ensembl:ENSG00000203710(gene)|go:"GO:0001855"(complement component C4b binding)|go:"GO:0001861"(complement component C4b receptor activity)|go:"GO:0001970"(positive regulation of activation of membrane attack complex)|go:"GO:0001971"(negative regulation of activation of membrane attack complex)|go:"GO:0002430"(complement receptor mediated signaling pathway)|go:"GO:0002435"(immune complex clearance by erythrocytes)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0004877"(complement component C3b receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005856"(cytoskeleton)|ensembl:ENST00000367051(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|ensembl:ENST00000367053(transcript)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0006958"(complement activation, classical pathway)|ensembl:ENST00000400960(transcript)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0001618"(virus receptor activity)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0001851"(complement component C3b binding)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045916"(negative regulation of complement activation)|go:"GO:0045918"(negative regulation of cytolysis)|go:"GO:0045957"(negative regulation of complement activation, alternative pathway)|go:"GO:0045959"(negative regulation of complement activation, classical pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:1900004"(negative regulation of serine-type endopeptidase activity)|go:"GO:1900005"(positive regulation of serine-type endopeptidase activity)|go:"GO:1900099"(negative regulation of plasma cell differentiation)|go:"GO:1904669"(ATP export)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|rcsb pdb:1GKG|rcsb pdb:1GKN|rcsb pdb:1GOP|rcsb pdb:1PPQ|rcsb pdb:2MCY|rcsb pdb:2MCZ|rcsb pdb:2Q7Z|reactome:R-HSA-6798695|reactome:R-HSA-8877330|reactome:R-HSA-977606|rcsb pdb:5FO9|refseq:NP_000564.2|refseq:NP_000642.3	-	comment:mint|function:Calcium-dependent and GlcNAc-binding lectin. Enhanced phagocytosis of S.typhimurium by neutrophils, suggesting an opsonic effect via the collagen region	-	figure legend:2A, 3B, 4A.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:0.92x10^-9(molar)	2020/12/18	2021/07/15	rogid:j6vRtYG3I6cn0c2TId/73bE/1To9606	rogid:gwNvQZmPMP1PCX8z/svSxkVBZt49606	rigid:jq/CFRTEQgy+uTqaobd/U87zRy0	false	-	his tag:c-c|mutation:1208-1208|sufficient binding region:42-1971	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75636	uniprotkb:P17927	intact:EBI-11786958|uniprotkb:Q6IBJ5|uniprotkb:Q8WW86|ensembl:ENSP00000270879	intact:EBI-2807625|ensembl:ENSP00000356018|ensembl:ENSP00000356020|ensembl:ENSP00000383744|uniprotkb:Q5SR43|uniprotkb:Q9UQV2|uniprotkb:Q5SR45|uniprotkb:Q16745|uniprotkb:Q16744	psi-mi:fcn3_human(display_long)|uniprotkb:FCN3(gene name)|psi-mi:FCN3(display_short)|uniprotkb:FCNH(gene name synonym)|uniprotkb:HAKA1(gene name synonym)|uniprotkb:Collagen/fibrinogen domain-containing lectin 3 p35(gene name synonym)|uniprotkb:Collagen/fibrinogen domain-containing protein 3(gene name synonym)|uniprotkb:Hakata antigen(gene name synonym)	psi-mi:cr1_human(display_long)|uniprotkb:CR1(gene name)|psi-mi:CR1(display_short)|uniprotkb:C3BR(gene name synonym)|uniprotkb:C3b/C4b receptor(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Jacquet et al. (2013)	imex:IM-29091|pubmed:23460739	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27034293|imex:IM-29091-23	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003656.2|refseq:NP_775628.1|ensembl:ENSG00000142748(gene)|ensembl:ENST00000270879(transcript)|go:"GO:0001867"(complement activation, lectin pathway)|go:"GO:0003823"(antigen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0006956"(complement activation)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0043654"(recognition of apoptotic cell)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0072562"(blood microparticle)|go:"GO:1902679"(negative regulation of RNA biosynthetic process)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|interpro:IPR036056|rcsb pdb:1LA5|rcsb pdb:2J5Z|rcsb pdb:2J60|rcsb pdb:2J64|reactome:R-HSA-166662|reactome:R-HSA-166663|reactome:R-HSA-2855086	ensembl:ENSG00000203710(gene)|go:"GO:0001855"(complement component C4b binding)|go:"GO:0001861"(complement component C4b receptor activity)|go:"GO:0001970"(positive regulation of activation of membrane attack complex)|go:"GO:0001971"(negative regulation of activation of membrane attack complex)|go:"GO:0002430"(complement receptor mediated signaling pathway)|go:"GO:0002435"(immune complex clearance by erythrocytes)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0004877"(complement component C3b receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005856"(cytoskeleton)|ensembl:ENST00000367051(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|ensembl:ENST00000367053(transcript)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0006958"(complement activation, classical pathway)|ensembl:ENST00000400960(transcript)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0001618"(virus receptor activity)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0001851"(complement component C3b binding)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045916"(negative regulation of complement activation)|go:"GO:0045918"(negative regulation of cytolysis)|go:"GO:0045957"(negative regulation of complement activation, alternative pathway)|go:"GO:0045959"(negative regulation of complement activation, classical pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:1900004"(negative regulation of serine-type endopeptidase activity)|go:"GO:1900005"(positive regulation of serine-type endopeptidase activity)|go:"GO:1900099"(negative regulation of plasma cell differentiation)|go:"GO:1904669"(ATP export)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|rcsb pdb:1GKG|rcsb pdb:1GKN|rcsb pdb:1GOP|rcsb pdb:1PPQ|rcsb pdb:2MCY|rcsb pdb:2MCZ|rcsb pdb:2Q7Z|reactome:R-HSA-6798695|reactome:R-HSA-8877330|reactome:R-HSA-977606|rcsb pdb:5FO9|refseq:NP_000564.2|refseq:NP_000642.3	-	-	-	figure legend:2A, number 3.|comment:weak interaction|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/18	2021/08/23	rogid:Uqrs95TKW2LaGqmcRkU9cu3v2FA9606	rogid:gwNvQZmPMP1PCX8z/svSxkVBZt49606	rigid:pCmpmK830xVd9xgt8iVbZ2pYACs	false	-	his tag:c-c|mutation:1208-1208|sufficient binding region:42-1971	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P11226	uniprotkb:P17927	intact:EBI-5325353|ensembl:ENSP00000363079|ensembl:ENSP00000502615|ensembl:ENSP00000502789|uniprotkb:Q4VB12|uniprotkb:Q4VB13|uniprotkb:Q86SI4|uniprotkb:Q96KE4|uniprotkb:Q96TF7|uniprotkb:Q96TF8|uniprotkb:Q96TF9|uniprotkb:Q4VB14|uniprotkb:Q5SQS3	intact:EBI-2807625|ensembl:ENSP00000356018|ensembl:ENSP00000356020|ensembl:ENSP00000383744|uniprotkb:Q5SR43|uniprotkb:Q9UQV2|uniprotkb:Q5SR45|uniprotkb:Q16745|uniprotkb:Q16744	psi-mi:mbl2_human(display_long)|uniprotkb:MBL2(gene name)|psi-mi:MBL2(display_short)|uniprotkb:COLEC1(gene name synonym)|uniprotkb:MBL(gene name synonym)|uniprotkb:Collectin-1(gene name synonym)|uniprotkb:MBP1(gene name synonym)|uniprotkb:Mannan-binding protein(gene name synonym)|uniprotkb:Mannose-binding lectin(gene name synonym)	psi-mi:cr1_human(display_long)|uniprotkb:CR1(gene name)|psi-mi:CR1(display_short)|uniprotkb:C3BR(gene name synonym)|uniprotkb:C3b/C4b receptor(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Jacquet et al. (2013)	imex:IM-29091|pubmed:23460739	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27034304|imex:IM-29091-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000165471(gene)|ensembl:ENST00000373968(transcript)|ensembl:ENST00000674931(transcript)|ensembl:ENST00000675947(transcript)|go:"GO:0001867"(complement activation, lectin pathway)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005537"(mannose binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0006953"(acute-phase response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008228"(opsonization)|go:"GO:0009986"(cell surface)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048525"(negative regulation of viral process)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR001304(C-type lectin)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR016186(C-type lectin-like)|refseq:XP_011538118.1|interpro:IPR018378|interpro:IPR033990|interpro:IPR037570|rcsb pdb:1HUP|interpro:IPR016187(C-type lectin fold)|reactome:R-HSA-166662|reactome:R-HSA-166663|refseq:NP_000233.1|refseq:XP_006717924.1|dip:DIP-61381N	ensembl:ENSG00000203710(gene)|go:"GO:0001855"(complement component C4b binding)|go:"GO:0001861"(complement component C4b receptor activity)|go:"GO:0001970"(positive regulation of activation of membrane attack complex)|go:"GO:0001971"(negative regulation of activation of membrane attack complex)|go:"GO:0002430"(complement receptor mediated signaling pathway)|go:"GO:0002435"(immune complex clearance by erythrocytes)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0004877"(complement component C3b receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005856"(cytoskeleton)|ensembl:ENST00000367051(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|ensembl:ENST00000367053(transcript)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0006958"(complement activation, classical pathway)|ensembl:ENST00000400960(transcript)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0001618"(virus receptor activity)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0001851"(complement component C3b binding)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045916"(negative regulation of complement activation)|go:"GO:0045918"(negative regulation of cytolysis)|go:"GO:0045957"(negative regulation of complement activation, alternative pathway)|go:"GO:0045959"(negative regulation of complement activation, classical pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:1900004"(negative regulation of serine-type endopeptidase activity)|go:"GO:1900005"(positive regulation of serine-type endopeptidase activity)|go:"GO:1900099"(negative regulation of plasma cell differentiation)|go:"GO:1904669"(ATP export)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|rcsb pdb:1GKG|rcsb pdb:1GKN|rcsb pdb:1GOP|rcsb pdb:1PPQ|rcsb pdb:2MCY|rcsb pdb:2MCZ|rcsb pdb:2Q7Z|reactome:R-HSA-6798695|reactome:R-HSA-8877330|reactome:R-HSA-977606|rcsb pdb:5FO9|refseq:NP_000564.2|refseq:NP_000642.3	-	-	-	figure legend:2B, number 1, 6C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/18	2021/07/15	rogid:uo0RM88uw3otObIVnOhUcOfW8yo9606	rogid:gwNvQZmPMP1PCX8z/svSxkVBZt49606	rigid:lTfTcf19ABoAM9EFegN6riIXxFA	false	-	his tag:c-c|sufficient binding region:1395-1648..1648	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75636	uniprotkb:P17927	intact:EBI-11786958|uniprotkb:Q6IBJ5|uniprotkb:Q8WW86|ensembl:ENSP00000270879	intact:EBI-2807625|ensembl:ENSP00000356018|ensembl:ENSP00000356020|ensembl:ENSP00000383744|uniprotkb:Q5SR43|uniprotkb:Q9UQV2|uniprotkb:Q5SR45|uniprotkb:Q16745|uniprotkb:Q16744	psi-mi:fcn3_human(display_long)|uniprotkb:FCN3(gene name)|psi-mi:FCN3(display_short)|uniprotkb:FCNH(gene name synonym)|uniprotkb:HAKA1(gene name synonym)|uniprotkb:Collagen/fibrinogen domain-containing lectin 3 p35(gene name synonym)|uniprotkb:Collagen/fibrinogen domain-containing protein 3(gene name synonym)|uniprotkb:Hakata antigen(gene name synonym)	psi-mi:cr1_human(display_long)|uniprotkb:CR1(gene name)|psi-mi:CR1(display_short)|uniprotkb:C3BR(gene name synonym)|uniprotkb:C3b/C4b receptor(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Jacquet et al. (2013)	imex:IM-29091|pubmed:23460739	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27034315|imex:IM-29091-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003656.2|refseq:NP_775628.1|ensembl:ENSG00000142748(gene)|ensembl:ENST00000270879(transcript)|go:"GO:0001867"(complement activation, lectin pathway)|go:"GO:0003823"(antigen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0006956"(complement activation)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0043654"(recognition of apoptotic cell)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0072562"(blood microparticle)|go:"GO:1902679"(negative regulation of RNA biosynthetic process)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|interpro:IPR036056|rcsb pdb:1LA5|rcsb pdb:2J5Z|rcsb pdb:2J60|rcsb pdb:2J64|reactome:R-HSA-166662|reactome:R-HSA-166663|reactome:R-HSA-2855086	ensembl:ENSG00000203710(gene)|go:"GO:0001855"(complement component C4b binding)|go:"GO:0001861"(complement component C4b receptor activity)|go:"GO:0001970"(positive regulation of activation of membrane attack complex)|go:"GO:0001971"(negative regulation of activation of membrane attack complex)|go:"GO:0002430"(complement receptor mediated signaling pathway)|go:"GO:0002435"(immune complex clearance by erythrocytes)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0004877"(complement component C3b receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005856"(cytoskeleton)|ensembl:ENST00000367051(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|ensembl:ENST00000367053(transcript)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0006958"(complement activation, classical pathway)|ensembl:ENST00000400960(transcript)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0001618"(virus receptor activity)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0001851"(complement component C3b binding)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045916"(negative regulation of complement activation)|go:"GO:0045918"(negative regulation of cytolysis)|go:"GO:0045957"(negative regulation of complement activation, alternative pathway)|go:"GO:0045959"(negative regulation of complement activation, classical pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:1900004"(negative regulation of serine-type endopeptidase activity)|go:"GO:1900005"(positive regulation of serine-type endopeptidase activity)|go:"GO:1900099"(negative regulation of plasma cell differentiation)|go:"GO:1904669"(ATP export)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|rcsb pdb:1GKG|rcsb pdb:1GKN|rcsb pdb:1GOP|rcsb pdb:1PPQ|rcsb pdb:2MCY|rcsb pdb:2MCZ|rcsb pdb:2Q7Z|reactome:R-HSA-6798695|reactome:R-HSA-8877330|reactome:R-HSA-977606|rcsb pdb:5FO9|refseq:NP_000564.2|refseq:NP_000642.3	-	-	-	figure legend:2B, number 3.|comment:weak interaction|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/18	2021/08/23	rogid:Uqrs95TKW2LaGqmcRkU9cu3v2FA9606	rogid:gwNvQZmPMP1PCX8z/svSxkVBZt49606	rigid:pCmpmK830xVd9xgt8iVbZ2pYACs	false	-	his tag:c-c|sufficient binding region:1395-1969	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15485	uniprotkb:P17927	intact:EBI-7468784|uniprotkb:A6NFG7|uniprotkb:Q9UC57|uniprotkb:Q6IS69|intact:MINT-5223224|uniprotkb:Q7M4P4|uniprotkb:A8K478|ensembl:ENSP00000291744	intact:EBI-2807625|ensembl:ENSP00000356018|ensembl:ENSP00000356020|ensembl:ENSP00000383744|uniprotkb:Q5SR43|uniprotkb:Q9UQV2|uniprotkb:Q5SR45|uniprotkb:Q16745|uniprotkb:Q16744	psi-mi:fcn2_human(display_long)|uniprotkb:FCN2(gene name)|psi-mi:FCN2(display_short)|uniprotkb:FCNL(gene name synonym)|uniprotkb:Ficolin-B(gene name synonym)|uniprotkb:Ficolin-beta(gene name synonym)|uniprotkb:L-ficolin(gene name synonym)|uniprotkb:Collagen/fibrinogen domain-containing protein 2(gene name synonym)|uniprotkb:Serum lectin p35(gene name synonym)|uniprotkb:37 kDa elastin-binding protein(gene name synonym)|uniprotkb:EBP-37(gene name synonym)|uniprotkb:Hucolin(gene name synonym)	psi-mi:cr1_human(display_long)|uniprotkb:CR1(gene name)|psi-mi:CR1(display_short)|uniprotkb:C3BR(gene name synonym)|uniprotkb:C3b/C4b receptor(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Jacquet et al. (2013)	imex:IM-29091|pubmed:23460739	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27034326|imex:IM-29091-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004099.2|refseq:NP_056652.1|ensembl:ENSG00000160339(gene)|ensembl:ENST00000291744(transcript)|go:"GO:0001867"(complement activation, lectin pathway)|go:"GO:0003823"(antigen binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0008228"(opsonization)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0043654"(recognition of apoptotic cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0097367"(carbohydrate derivative binding)|go:"GO:2001065"(mannan binding)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|interpro:IPR036056|mint:Q15485|rcsb pdb:2J0G|rcsb pdb:2J0H|rcsb pdb:2J0Y|rcsb pdb:2J1G|rcsb pdb:2J2P|rcsb pdb:2J3F|rcsb pdb:2J3G|rcsb pdb:2J3O|rcsb pdb:2J3U|rcsb pdb:2J61|rcsb pdb:4NYT|rcsb pdb:4R9J|rcsb pdb:4R9T|reactome:R-HSA-166662|reactome:R-HSA-166663|reactome:R-HSA-2855086	ensembl:ENSG00000203710(gene)|go:"GO:0001855"(complement component C4b binding)|go:"GO:0001861"(complement component C4b receptor activity)|go:"GO:0001970"(positive regulation of activation of membrane attack complex)|go:"GO:0001971"(negative regulation of activation of membrane attack complex)|go:"GO:0002430"(complement receptor mediated signaling pathway)|go:"GO:0002435"(immune complex clearance by erythrocytes)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0004877"(complement component C3b receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005856"(cytoskeleton)|ensembl:ENST00000367051(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|ensembl:ENST00000367053(transcript)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0006958"(complement activation, classical pathway)|ensembl:ENST00000400960(transcript)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0001618"(virus receptor activity)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0001851"(complement component C3b binding)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045916"(negative regulation of complement activation)|go:"GO:0045918"(negative regulation of cytolysis)|go:"GO:0045957"(negative regulation of complement activation, alternative pathway)|go:"GO:0045959"(negative regulation of complement activation, classical pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:1900004"(negative regulation of serine-type endopeptidase activity)|go:"GO:1900005"(positive regulation of serine-type endopeptidase activity)|go:"GO:1900099"(negative regulation of plasma cell differentiation)|go:"GO:1904669"(ATP export)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|rcsb pdb:1GKG|rcsb pdb:1GKN|rcsb pdb:1GOP|rcsb pdb:1PPQ|rcsb pdb:2MCY|rcsb pdb:2MCZ|rcsb pdb:2Q7Z|reactome:R-HSA-6798695|reactome:R-HSA-8877330|reactome:R-HSA-977606|rcsb pdb:5FO9|refseq:NP_000564.2|refseq:NP_000642.3	-	comment:mint|function:Calcium-dependent and GlcNAc-binding lectin. Enhanced phagocytosis of S.typhimurium by neutrophils, suggesting an opsonic effect via the collagen region	-	figure legend:2B, number 2, 6C|comment:weak interaction|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/18	2021/07/15	rogid:j6vRtYG3I6cn0c2TId/73bE/1To9606	rogid:gwNvQZmPMP1PCX8z/svSxkVBZt49606	rigid:jq/CFRTEQgy+uTqaobd/U87zRy0	false	-	his tag:c-c|sufficient binding region:1395-1648..1648	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P11226	uniprotkb:P17927	intact:EBI-5325353|ensembl:ENSP00000363079|ensembl:ENSP00000502615|ensembl:ENSP00000502789|uniprotkb:Q4VB12|uniprotkb:Q4VB13|uniprotkb:Q86SI4|uniprotkb:Q96KE4|uniprotkb:Q96TF7|uniprotkb:Q96TF8|uniprotkb:Q96TF9|uniprotkb:Q4VB14|uniprotkb:Q5SQS3	intact:EBI-2807625|ensembl:ENSP00000356018|ensembl:ENSP00000356020|ensembl:ENSP00000383744|uniprotkb:Q5SR43|uniprotkb:Q9UQV2|uniprotkb:Q5SR45|uniprotkb:Q16745|uniprotkb:Q16744	psi-mi:mbl2_human(display_long)|uniprotkb:MBL2(gene name)|psi-mi:MBL2(display_short)|uniprotkb:COLEC1(gene name synonym)|uniprotkb:MBL(gene name synonym)|uniprotkb:Collectin-1(gene name synonym)|uniprotkb:MBP1(gene name synonym)|uniprotkb:Mannan-binding protein(gene name synonym)|uniprotkb:Mannose-binding lectin(gene name synonym)	psi-mi:cr1_human(display_long)|uniprotkb:CR1(gene name)|psi-mi:CR1(display_short)|uniprotkb:C3BR(gene name synonym)|uniprotkb:C3b/C4b receptor(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Jacquet et al. (2013)	imex:IM-29091|pubmed:23460739	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27034337|imex:IM-29091-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000165471(gene)|ensembl:ENST00000373968(transcript)|ensembl:ENST00000674931(transcript)|ensembl:ENST00000675947(transcript)|go:"GO:0001867"(complement activation, lectin pathway)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005537"(mannose binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0006953"(acute-phase response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008228"(opsonization)|go:"GO:0009986"(cell surface)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048525"(negative regulation of viral process)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR001304(C-type lectin)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR016186(C-type lectin-like)|refseq:XP_011538118.1|interpro:IPR018378|interpro:IPR033990|interpro:IPR037570|rcsb pdb:1HUP|interpro:IPR016187(C-type lectin fold)|reactome:R-HSA-166662|reactome:R-HSA-166663|refseq:NP_000233.1|refseq:XP_006717924.1|dip:DIP-61381N	ensembl:ENSG00000203710(gene)|go:"GO:0001855"(complement component C4b binding)|go:"GO:0001861"(complement component C4b receptor activity)|go:"GO:0001970"(positive regulation of activation of membrane attack complex)|go:"GO:0001971"(negative regulation of activation of membrane attack complex)|go:"GO:0002430"(complement receptor mediated signaling pathway)|go:"GO:0002435"(immune complex clearance by erythrocytes)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0004877"(complement component C3b receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005856"(cytoskeleton)|ensembl:ENST00000367051(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|ensembl:ENST00000367053(transcript)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0006958"(complement activation, classical pathway)|ensembl:ENST00000400960(transcript)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0001618"(virus receptor activity)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0001851"(complement component C3b binding)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045916"(negative regulation of complement activation)|go:"GO:0045918"(negative regulation of cytolysis)|go:"GO:0045957"(negative regulation of complement activation, alternative pathway)|go:"GO:0045959"(negative regulation of complement activation, classical pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:1900004"(negative regulation of serine-type endopeptidase activity)|go:"GO:1900005"(positive regulation of serine-type endopeptidase activity)|go:"GO:1900099"(negative regulation of plasma cell differentiation)|go:"GO:1904669"(ATP export)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|rcsb pdb:1GKG|rcsb pdb:1GKN|rcsb pdb:1GOP|rcsb pdb:1PPQ|rcsb pdb:2MCY|rcsb pdb:2MCZ|rcsb pdb:2Q7Z|reactome:R-HSA-6798695|reactome:R-HSA-8877330|reactome:R-HSA-977606|rcsb pdb:5FO9|refseq:NP_000564.2|refseq:NP_000642.3	-	-	-	figure legend:2C, number 1.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/18	2021/07/15	rogid:uo0RM88uw3otObIVnOhUcOfW8yo9606	rogid:gwNvQZmPMP1PCX8z/svSxkVBZt49606	rigid:lTfTcf19ABoAM9EFegN6riIXxFA	false	-	his tag:c-c|sufficient binding region:1395-1969	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P11226	uniprotkb:P17927	intact:EBI-5325353|ensembl:ENSP00000363079|ensembl:ENSP00000502615|ensembl:ENSP00000502789|uniprotkb:Q4VB12|uniprotkb:Q4VB13|uniprotkb:Q86SI4|uniprotkb:Q96KE4|uniprotkb:Q96TF7|uniprotkb:Q96TF8|uniprotkb:Q96TF9|uniprotkb:Q4VB14|uniprotkb:Q5SQS3	intact:EBI-2807625|ensembl:ENSP00000356018|ensembl:ENSP00000356020|ensembl:ENSP00000383744|uniprotkb:Q5SR43|uniprotkb:Q9UQV2|uniprotkb:Q5SR45|uniprotkb:Q16745|uniprotkb:Q16744	psi-mi:mbl2_human(display_long)|uniprotkb:MBL2(gene name)|psi-mi:MBL2(display_short)|uniprotkb:COLEC1(gene name synonym)|uniprotkb:MBL(gene name synonym)|uniprotkb:Collectin-1(gene name synonym)|uniprotkb:MBP1(gene name synonym)|uniprotkb:Mannan-binding protein(gene name synonym)|uniprotkb:Mannose-binding lectin(gene name synonym)	psi-mi:cr1_human(display_long)|uniprotkb:CR1(gene name)|psi-mi:CR1(display_short)|uniprotkb:C3BR(gene name synonym)|uniprotkb:C3b/C4b receptor(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Jacquet et al. (2013)	imex:IM-29091|pubmed:23460739	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27034345|imex:IM-29091-25	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000165471(gene)|ensembl:ENST00000373968(transcript)|ensembl:ENST00000674931(transcript)|ensembl:ENST00000675947(transcript)|go:"GO:0001867"(complement activation, lectin pathway)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005537"(mannose binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0006953"(acute-phase response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008228"(opsonization)|go:"GO:0009986"(cell surface)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048525"(negative regulation of viral process)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR001304(C-type lectin)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR016186(C-type lectin-like)|refseq:XP_011538118.1|interpro:IPR018378|interpro:IPR033990|interpro:IPR037570|rcsb pdb:1HUP|interpro:IPR016187(C-type lectin fold)|reactome:R-HSA-166662|reactome:R-HSA-166663|refseq:NP_000233.1|refseq:XP_006717924.1|dip:DIP-61381N	ensembl:ENSG00000203710(gene)|go:"GO:0001855"(complement component C4b binding)|go:"GO:0001861"(complement component C4b receptor activity)|go:"GO:0001970"(positive regulation of activation of membrane attack complex)|go:"GO:0001971"(negative regulation of activation of membrane attack complex)|go:"GO:0002430"(complement receptor mediated signaling pathway)|go:"GO:0002435"(immune complex clearance by erythrocytes)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0004877"(complement component C3b receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005856"(cytoskeleton)|ensembl:ENST00000367051(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|ensembl:ENST00000367053(transcript)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0006958"(complement activation, classical pathway)|ensembl:ENST00000400960(transcript)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0001618"(virus receptor activity)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0001851"(complement component C3b binding)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045916"(negative regulation of complement activation)|go:"GO:0045918"(negative regulation of cytolysis)|go:"GO:0045957"(negative regulation of complement activation, alternative pathway)|go:"GO:0045959"(negative regulation of complement activation, classical pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:1900004"(negative regulation of serine-type endopeptidase activity)|go:"GO:1900005"(positive regulation of serine-type endopeptidase activity)|go:"GO:1900099"(negative regulation of plasma cell differentiation)|go:"GO:1904669"(ATP export)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|rcsb pdb:1GKG|rcsb pdb:1GKN|rcsb pdb:1GOP|rcsb pdb:1PPQ|rcsb pdb:2MCY|rcsb pdb:2MCZ|rcsb pdb:2Q7Z|reactome:R-HSA-6798695|reactome:R-HSA-8877330|reactome:R-HSA-977606|rcsb pdb:5FO9|refseq:NP_000564.2|refseq:NP_000642.3	-	-	-	figure legend:2C, number 2.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/18	2021/07/15	rogid:uo0RM88uw3otObIVnOhUcOfW8yo9606	rogid:gwNvQZmPMP1PCX8z/svSxkVBZt49606	rigid:lTfTcf19ABoAM9EFegN6riIXxFA	false	-	sufficient binding region:1395-1969	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15485	uniprotkb:P17927	intact:EBI-7468784|uniprotkb:A6NFG7|uniprotkb:Q9UC57|uniprotkb:Q6IS69|intact:MINT-5223224|uniprotkb:Q7M4P4|uniprotkb:A8K478|ensembl:ENSP00000291744	intact:EBI-2807625|ensembl:ENSP00000356018|ensembl:ENSP00000356020|ensembl:ENSP00000383744|uniprotkb:Q5SR43|uniprotkb:Q9UQV2|uniprotkb:Q5SR45|uniprotkb:Q16745|uniprotkb:Q16744	psi-mi:fcn2_human(display_long)|uniprotkb:FCN2(gene name)|psi-mi:FCN2(display_short)|uniprotkb:FCNL(gene name synonym)|uniprotkb:Ficolin-B(gene name synonym)|uniprotkb:Ficolin-beta(gene name synonym)|uniprotkb:L-ficolin(gene name synonym)|uniprotkb:Collagen/fibrinogen domain-containing protein 2(gene name synonym)|uniprotkb:Serum lectin p35(gene name synonym)|uniprotkb:37 kDa elastin-binding protein(gene name synonym)|uniprotkb:EBP-37(gene name synonym)|uniprotkb:Hucolin(gene name synonym)	psi-mi:cr1_human(display_long)|uniprotkb:CR1(gene name)|psi-mi:CR1(display_short)|uniprotkb:C3BR(gene name synonym)|uniprotkb:C3b/C4b receptor(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Jacquet et al. (2013)	imex:IM-29091|pubmed:23460739	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27034353|imex:IM-29091-27	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004099.2|refseq:NP_056652.1|ensembl:ENSG00000160339(gene)|ensembl:ENST00000291744(transcript)|go:"GO:0001867"(complement activation, lectin pathway)|go:"GO:0003823"(antigen binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0008228"(opsonization)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0043654"(recognition of apoptotic cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0097367"(carbohydrate derivative binding)|go:"GO:2001065"(mannan binding)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|interpro:IPR036056|mint:Q15485|rcsb pdb:2J0G|rcsb pdb:2J0H|rcsb pdb:2J0Y|rcsb pdb:2J1G|rcsb pdb:2J2P|rcsb pdb:2J3F|rcsb pdb:2J3G|rcsb pdb:2J3O|rcsb pdb:2J3U|rcsb pdb:2J61|rcsb pdb:4NYT|rcsb pdb:4R9J|rcsb pdb:4R9T|reactome:R-HSA-166662|reactome:R-HSA-166663|reactome:R-HSA-2855086	ensembl:ENSG00000203710(gene)|go:"GO:0001855"(complement component C4b binding)|go:"GO:0001861"(complement component C4b receptor activity)|go:"GO:0001970"(positive regulation of activation of membrane attack complex)|go:"GO:0001971"(negative regulation of activation of membrane attack complex)|go:"GO:0002430"(complement receptor mediated signaling pathway)|go:"GO:0002435"(immune complex clearance by erythrocytes)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0004877"(complement component C3b receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005856"(cytoskeleton)|ensembl:ENST00000367051(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|ensembl:ENST00000367053(transcript)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0006958"(complement activation, classical pathway)|ensembl:ENST00000400960(transcript)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0001618"(virus receptor activity)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0001851"(complement component C3b binding)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045916"(negative regulation of complement activation)|go:"GO:0045918"(negative regulation of cytolysis)|go:"GO:0045957"(negative regulation of complement activation, alternative pathway)|go:"GO:0045959"(negative regulation of complement activation, classical pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:1900004"(negative regulation of serine-type endopeptidase activity)|go:"GO:1900005"(positive regulation of serine-type endopeptidase activity)|go:"GO:1900099"(negative regulation of plasma cell differentiation)|go:"GO:1904669"(ATP export)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|rcsb pdb:1GKG|rcsb pdb:1GKN|rcsb pdb:1GOP|rcsb pdb:1PPQ|rcsb pdb:2MCY|rcsb pdb:2MCZ|rcsb pdb:2Q7Z|reactome:R-HSA-6798695|reactome:R-HSA-8877330|reactome:R-HSA-977606|rcsb pdb:5FO9|refseq:NP_000564.2|refseq:NP_000642.3	-	comment:mint|function:Calcium-dependent and GlcNAc-binding lectin. Enhanced phagocytosis of S.typhimurium by neutrophils, suggesting an opsonic effect via the collagen region	-	figure legend:2D, number 1.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/18	2021/07/15	rogid:j6vRtYG3I6cn0c2TId/73bE/1To9606	rogid:gwNvQZmPMP1PCX8z/svSxkVBZt49606	rigid:jq/CFRTEQgy+uTqaobd/U87zRy0	false	-	his tag:c-c|sufficient binding region:1395-1969	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15485	uniprotkb:P17927	intact:EBI-7468784|uniprotkb:A6NFG7|uniprotkb:Q9UC57|uniprotkb:Q6IS69|intact:MINT-5223224|uniprotkb:Q7M4P4|uniprotkb:A8K478|ensembl:ENSP00000291744	intact:EBI-2807625|ensembl:ENSP00000356018|ensembl:ENSP00000356020|ensembl:ENSP00000383744|uniprotkb:Q5SR43|uniprotkb:Q9UQV2|uniprotkb:Q5SR45|uniprotkb:Q16745|uniprotkb:Q16744	psi-mi:fcn2_human(display_long)|uniprotkb:FCN2(gene name)|psi-mi:FCN2(display_short)|uniprotkb:FCNL(gene name synonym)|uniprotkb:Ficolin-B(gene name synonym)|uniprotkb:Ficolin-beta(gene name synonym)|uniprotkb:L-ficolin(gene name synonym)|uniprotkb:Collagen/fibrinogen domain-containing protein 2(gene name synonym)|uniprotkb:Serum lectin p35(gene name synonym)|uniprotkb:37 kDa elastin-binding protein(gene name synonym)|uniprotkb:EBP-37(gene name synonym)|uniprotkb:Hucolin(gene name synonym)	psi-mi:cr1_human(display_long)|uniprotkb:CR1(gene name)|psi-mi:CR1(display_short)|uniprotkb:C3BR(gene name synonym)|uniprotkb:C3b/C4b receptor(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Jacquet et al. (2013)	imex:IM-29091|pubmed:23460739	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27034361|imex:IM-29091-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004099.2|refseq:NP_056652.1|ensembl:ENSG00000160339(gene)|ensembl:ENST00000291744(transcript)|go:"GO:0001867"(complement activation, lectin pathway)|go:"GO:0003823"(antigen binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0008228"(opsonization)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0043654"(recognition of apoptotic cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0097367"(carbohydrate derivative binding)|go:"GO:2001065"(mannan binding)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|interpro:IPR036056|mint:Q15485|rcsb pdb:2J0G|rcsb pdb:2J0H|rcsb pdb:2J0Y|rcsb pdb:2J1G|rcsb pdb:2J2P|rcsb pdb:2J3F|rcsb pdb:2J3G|rcsb pdb:2J3O|rcsb pdb:2J3U|rcsb pdb:2J61|rcsb pdb:4NYT|rcsb pdb:4R9J|rcsb pdb:4R9T|reactome:R-HSA-166662|reactome:R-HSA-166663|reactome:R-HSA-2855086	ensembl:ENSG00000203710(gene)|go:"GO:0001855"(complement component C4b binding)|go:"GO:0001861"(complement component C4b receptor activity)|go:"GO:0001970"(positive regulation of activation of membrane attack complex)|go:"GO:0001971"(negative regulation of activation of membrane attack complex)|go:"GO:0002430"(complement receptor mediated signaling pathway)|go:"GO:0002435"(immune complex clearance by erythrocytes)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0004877"(complement component C3b receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005856"(cytoskeleton)|ensembl:ENST00000367051(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|ensembl:ENST00000367053(transcript)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0006958"(complement activation, classical pathway)|ensembl:ENST00000400960(transcript)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0001618"(virus receptor activity)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0001851"(complement component C3b binding)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045916"(negative regulation of complement activation)|go:"GO:0045918"(negative regulation of cytolysis)|go:"GO:0045957"(negative regulation of complement activation, alternative pathway)|go:"GO:0045959"(negative regulation of complement activation, classical pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:1900004"(negative regulation of serine-type endopeptidase activity)|go:"GO:1900005"(positive regulation of serine-type endopeptidase activity)|go:"GO:1900099"(negative regulation of plasma cell differentiation)|go:"GO:1904669"(ATP export)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|rcsb pdb:1GKG|rcsb pdb:1GKN|rcsb pdb:1GOP|rcsb pdb:1PPQ|rcsb pdb:2MCY|rcsb pdb:2MCZ|rcsb pdb:2Q7Z|reactome:R-HSA-6798695|reactome:R-HSA-8877330|reactome:R-HSA-977606|rcsb pdb:5FO9|refseq:NP_000564.2|refseq:NP_000642.3	-	comment:mint|function:Calcium-dependent and GlcNAc-binding lectin. Enhanced phagocytosis of S.typhimurium by neutrophils, suggesting an opsonic effect via the collagen region	-	figure legend:2D, number 2.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/18	2021/07/15	rogid:j6vRtYG3I6cn0c2TId/73bE/1To9606	rogid:gwNvQZmPMP1PCX8z/svSxkVBZt49606	rigid:jq/CFRTEQgy+uTqaobd/U87zRy0	false	-	sufficient binding region:1395-1969	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15485	uniprotkb:P17927	intact:EBI-7468784|uniprotkb:A6NFG7|uniprotkb:Q9UC57|uniprotkb:Q6IS69|intact:MINT-5223224|uniprotkb:Q7M4P4|uniprotkb:A8K478|ensembl:ENSP00000291744	intact:EBI-2807625|ensembl:ENSP00000356018|ensembl:ENSP00000356020|ensembl:ENSP00000383744|uniprotkb:Q5SR43|uniprotkb:Q9UQV2|uniprotkb:Q5SR45|uniprotkb:Q16745|uniprotkb:Q16744	psi-mi:fcn2_human(display_long)|uniprotkb:FCN2(gene name)|psi-mi:FCN2(display_short)|uniprotkb:FCNL(gene name synonym)|uniprotkb:Ficolin-B(gene name synonym)|uniprotkb:Ficolin-beta(gene name synonym)|uniprotkb:L-ficolin(gene name synonym)|uniprotkb:Collagen/fibrinogen domain-containing protein 2(gene name synonym)|uniprotkb:Serum lectin p35(gene name synonym)|uniprotkb:37 kDa elastin-binding protein(gene name synonym)|uniprotkb:EBP-37(gene name synonym)|uniprotkb:Hucolin(gene name synonym)	psi-mi:cr1_human(display_long)|uniprotkb:CR1(gene name)|psi-mi:CR1(display_short)|uniprotkb:C3BR(gene name synonym)|uniprotkb:C3b/C4b receptor(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Jacquet et al. (2013)	imex:IM-29091|pubmed:23460739	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27034818|imex:IM-29091-29	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004099.2|refseq:NP_056652.1|ensembl:ENSG00000160339(gene)|ensembl:ENST00000291744(transcript)|go:"GO:0001867"(complement activation, lectin pathway)|go:"GO:0003823"(antigen binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0008228"(opsonization)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0043654"(recognition of apoptotic cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0097367"(carbohydrate derivative binding)|go:"GO:2001065"(mannan binding)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|interpro:IPR036056|mint:Q15485|rcsb pdb:2J0G|rcsb pdb:2J0H|rcsb pdb:2J0Y|rcsb pdb:2J1G|rcsb pdb:2J2P|rcsb pdb:2J3F|rcsb pdb:2J3G|rcsb pdb:2J3O|rcsb pdb:2J3U|rcsb pdb:2J61|rcsb pdb:4NYT|rcsb pdb:4R9J|rcsb pdb:4R9T|reactome:R-HSA-166662|reactome:R-HSA-166663|reactome:R-HSA-2855086	ensembl:ENSG00000203710(gene)|go:"GO:0001855"(complement component C4b binding)|go:"GO:0001861"(complement component C4b receptor activity)|go:"GO:0001970"(positive regulation of activation of membrane attack complex)|go:"GO:0001971"(negative regulation of activation of membrane attack complex)|go:"GO:0002430"(complement receptor mediated signaling pathway)|go:"GO:0002435"(immune complex clearance by erythrocytes)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0004877"(complement component C3b receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005856"(cytoskeleton)|ensembl:ENST00000367051(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|ensembl:ENST00000367053(transcript)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0006958"(complement activation, classical pathway)|ensembl:ENST00000400960(transcript)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0001618"(virus receptor activity)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0001851"(complement component C3b binding)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045916"(negative regulation of complement activation)|go:"GO:0045918"(negative regulation of cytolysis)|go:"GO:0045957"(negative regulation of complement activation, alternative pathway)|go:"GO:0045959"(negative regulation of complement activation, classical pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:1900004"(negative regulation of serine-type endopeptidase activity)|go:"GO:1900005"(positive regulation of serine-type endopeptidase activity)|go:"GO:1900099"(negative regulation of plasma cell differentiation)|go:"GO:1904669"(ATP export)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|rcsb pdb:1GKG|rcsb pdb:1GKN|rcsb pdb:1GOP|rcsb pdb:1PPQ|rcsb pdb:2MCY|rcsb pdb:2MCZ|rcsb pdb:2Q7Z|reactome:R-HSA-6798695|reactome:R-HSA-8877330|reactome:R-HSA-977606|rcsb pdb:5FO9|refseq:NP_000564.2|refseq:NP_000642.3	-	comment:mint|function:Calcium-dependent and GlcNAc-binding lectin. Enhanced phagocytosis of S.typhimurium by neutrophils, suggesting an opsonic effect via the collagen region	-	figure legend:3B, 4B|comment:"CR1:The expression system and presence/absence of a His-tag is not stated."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:0.63x10^-9(molar)	2020/12/18	2021/07/15	rogid:j6vRtYG3I6cn0c2TId/73bE/1To9606	rogid:gwNvQZmPMP1PCX8z/svSxkVBZt49606	rigid:jq/CFRTEQgy+uTqaobd/U87zRy0	false	-	his tag:c-c|sufficient binding region:1395-1969	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P11226	uniprotkb:P17927	intact:EBI-5325353|ensembl:ENSP00000363079|ensembl:ENSP00000502615|ensembl:ENSP00000502789|uniprotkb:Q4VB12|uniprotkb:Q4VB13|uniprotkb:Q86SI4|uniprotkb:Q96KE4|uniprotkb:Q96TF7|uniprotkb:Q96TF8|uniprotkb:Q96TF9|uniprotkb:Q4VB14|uniprotkb:Q5SQS3	intact:EBI-2807625|ensembl:ENSP00000356018|ensembl:ENSP00000356020|ensembl:ENSP00000383744|uniprotkb:Q5SR43|uniprotkb:Q9UQV2|uniprotkb:Q5SR45|uniprotkb:Q16745|uniprotkb:Q16744	psi-mi:mbl2_human(display_long)|uniprotkb:MBL2(gene name)|psi-mi:MBL2(display_short)|uniprotkb:COLEC1(gene name synonym)|uniprotkb:MBL(gene name synonym)|uniprotkb:Collectin-1(gene name synonym)|uniprotkb:MBP1(gene name synonym)|uniprotkb:Mannan-binding protein(gene name synonym)|uniprotkb:Mannose-binding lectin(gene name synonym)	psi-mi:cr1_human(display_long)|uniprotkb:CR1(gene name)|psi-mi:CR1(display_short)|uniprotkb:C3BR(gene name synonym)|uniprotkb:C3b/C4b receptor(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Jacquet et al. (2013)	imex:IM-29091|pubmed:23460739	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27034832|imex:IM-29091-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000165471(gene)|ensembl:ENST00000373968(transcript)|ensembl:ENST00000674931(transcript)|ensembl:ENST00000675947(transcript)|go:"GO:0001867"(complement activation, lectin pathway)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005537"(mannose binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0006953"(acute-phase response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008228"(opsonization)|go:"GO:0009986"(cell surface)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048525"(negative regulation of viral process)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR001304(C-type lectin)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR016186(C-type lectin-like)|refseq:XP_011538118.1|interpro:IPR018378|interpro:IPR033990|interpro:IPR037570|rcsb pdb:1HUP|interpro:IPR016187(C-type lectin fold)|reactome:R-HSA-166662|reactome:R-HSA-166663|refseq:NP_000233.1|refseq:XP_006717924.1|dip:DIP-61381N	ensembl:ENSG00000203710(gene)|go:"GO:0001855"(complement component C4b binding)|go:"GO:0001861"(complement component C4b receptor activity)|go:"GO:0001970"(positive regulation of activation of membrane attack complex)|go:"GO:0001971"(negative regulation of activation of membrane attack complex)|go:"GO:0002430"(complement receptor mediated signaling pathway)|go:"GO:0002435"(immune complex clearance by erythrocytes)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0004877"(complement component C3b receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005856"(cytoskeleton)|ensembl:ENST00000367051(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|ensembl:ENST00000367053(transcript)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0006958"(complement activation, classical pathway)|ensembl:ENST00000400960(transcript)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0001618"(virus receptor activity)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0001851"(complement component C3b binding)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045916"(negative regulation of complement activation)|go:"GO:0045918"(negative regulation of cytolysis)|go:"GO:0045957"(negative regulation of complement activation, alternative pathway)|go:"GO:0045959"(negative regulation of complement activation, classical pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:1900004"(negative regulation of serine-type endopeptidase activity)|go:"GO:1900005"(positive regulation of serine-type endopeptidase activity)|go:"GO:1900099"(negative regulation of plasma cell differentiation)|go:"GO:1904669"(ATP export)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|rcsb pdb:1GKG|rcsb pdb:1GKN|rcsb pdb:1GOP|rcsb pdb:1PPQ|rcsb pdb:2MCY|rcsb pdb:2MCZ|rcsb pdb:2Q7Z|reactome:R-HSA-6798695|reactome:R-HSA-8877330|reactome:R-HSA-977606|rcsb pdb:5FO9|refseq:NP_000564.2|refseq:NP_000642.3	-	-	-	figure legend:3A,4A, 5B|comment:"CR1:The expression system and presence/absence of a His-tag is not stated."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:0.37x10^-9(molar)	2020/12/18	2021/07/15	rogid:uo0RM88uw3otObIVnOhUcOfW8yo9606	rogid:gwNvQZmPMP1PCX8z/svSxkVBZt49606	rigid:lTfTcf19ABoAM9EFegN6riIXxFA	false	mutation disrupting interaction strength:75-75	his tag:c-c|sufficient binding region:1395-1969	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P17927	uniprotkb:Q15485	intact:EBI-2807625|ensembl:ENSP00000356018|ensembl:ENSP00000356020|ensembl:ENSP00000383744|uniprotkb:Q5SR43|uniprotkb:Q9UQV2|uniprotkb:Q5SR45|uniprotkb:Q16745|uniprotkb:Q16744	intact:EBI-7468784|uniprotkb:A6NFG7|uniprotkb:Q9UC57|uniprotkb:Q6IS69|intact:MINT-5223224|uniprotkb:Q7M4P4|uniprotkb:A8K478|ensembl:ENSP00000291744	psi-mi:cr1_human(display_long)|uniprotkb:CR1(gene name)|psi-mi:CR1(display_short)|uniprotkb:C3BR(gene name synonym)|uniprotkb:C3b/C4b receptor(gene name synonym)	psi-mi:fcn2_human(display_long)|uniprotkb:FCN2(gene name)|psi-mi:FCN2(display_short)|uniprotkb:FCNL(gene name synonym)|uniprotkb:Ficolin-B(gene name synonym)|uniprotkb:Ficolin-beta(gene name synonym)|uniprotkb:L-ficolin(gene name synonym)|uniprotkb:Collagen/fibrinogen domain-containing protein 2(gene name synonym)|uniprotkb:Serum lectin p35(gene name synonym)|uniprotkb:37 kDa elastin-binding protein(gene name synonym)|uniprotkb:EBP-37(gene name synonym)|uniprotkb:Hucolin(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Jacquet et al. (2013)	imex:IM-29091|pubmed:23460739	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27034879|imex:IM-29091-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000203710(gene)|go:"GO:0001855"(complement component C4b binding)|go:"GO:0001861"(complement component C4b receptor activity)|go:"GO:0001970"(positive regulation of activation of membrane attack complex)|go:"GO:0001971"(negative regulation of activation of membrane attack complex)|go:"GO:0002430"(complement receptor mediated signaling pathway)|go:"GO:0002435"(immune complex clearance by erythrocytes)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0004877"(complement component C3b receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005856"(cytoskeleton)|ensembl:ENST00000367051(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|ensembl:ENST00000367053(transcript)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0006958"(complement activation, classical pathway)|ensembl:ENST00000400960(transcript)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0001618"(virus receptor activity)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0001851"(complement component C3b binding)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045916"(negative regulation of complement activation)|go:"GO:0045918"(negative regulation of cytolysis)|go:"GO:0045957"(negative regulation of complement activation, alternative pathway)|go:"GO:0045959"(negative regulation of complement activation, classical pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:1900004"(negative regulation of serine-type endopeptidase activity)|go:"GO:1900005"(positive regulation of serine-type endopeptidase activity)|go:"GO:1900099"(negative regulation of plasma cell differentiation)|go:"GO:1904669"(ATP export)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|rcsb pdb:1GKG|rcsb pdb:1GKN|rcsb pdb:1GOP|rcsb pdb:1PPQ|rcsb pdb:2MCY|rcsb pdb:2MCZ|rcsb pdb:2Q7Z|reactome:R-HSA-6798695|reactome:R-HSA-8877330|reactome:R-HSA-977606|rcsb pdb:5FO9|refseq:NP_000564.2|refseq:NP_000642.3	refseq:NP_004099.2|refseq:NP_056652.1|ensembl:ENSG00000160339(gene)|ensembl:ENST00000291744(transcript)|go:"GO:0001867"(complement activation, lectin pathway)|go:"GO:0003823"(antigen binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0008228"(opsonization)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0043654"(recognition of apoptotic cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0097367"(carbohydrate derivative binding)|go:"GO:2001065"(mannan binding)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|interpro:IPR036056|mint:Q15485|rcsb pdb:2J0G|rcsb pdb:2J0H|rcsb pdb:2J0Y|rcsb pdb:2J1G|rcsb pdb:2J2P|rcsb pdb:2J3F|rcsb pdb:2J3G|rcsb pdb:2J3O|rcsb pdb:2J3U|rcsb pdb:2J61|rcsb pdb:4NYT|rcsb pdb:4R9J|rcsb pdb:4R9T|reactome:R-HSA-166662|reactome:R-HSA-166663|reactome:R-HSA-2855086	-	-	comment:mint|function:Calcium-dependent and GlcNAc-binding lectin. Enhanced phagocytosis of S.typhimurium by neutrophils, suggesting an opsonic effect via the collagen region	figure legend:4B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/18	2021/07/15	rogid:gwNvQZmPMP1PCX8z/svSxkVBZt49606	rogid:j6vRtYG3I6cn0c2TId/73bE/1To9606	rigid:gMezkIqmmTkgscuhtkMJj/JuUQw	false	his tag:c-c|mutation:1208-1208|sufficient binding region:42-1971	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P17927	uniprotkb:P48740-2	intact:EBI-2807625|ensembl:ENSP00000356018|ensembl:ENSP00000356020|ensembl:ENSP00000383744|uniprotkb:Q5SR43|uniprotkb:Q9UQV2|uniprotkb:Q5SR45|uniprotkb:Q16745|uniprotkb:Q16744	intact:EBI-26435098|ensembl:ENSP00000296280	psi-mi:cr1_human(display_long)|uniprotkb:CR1(gene name)|psi-mi:CR1(display_short)|uniprotkb:C3BR(gene name synonym)|uniprotkb:C3b/C4b receptor(gene name synonym)	psi-mi:p48740-2(display_long)|uniprotkb:Mannose-binding protein-associated serine protease(gene name synonym)|uniprotkb:Ra-reactive factor serine protease p100(gene name synonym)|uniprotkb:Serine protease 5(gene name synonym)|uniprotkb:MASP-3(isoform synonym)|uniprotkb:MASP1(gene name)|psi-mi:MASP1(display_short)|uniprotkb:CRARF(gene name synonym)|uniprotkb:CRARF1(gene name synonym)|uniprotkb:PRSS5(gene name synonym)|uniprotkb:Complement factor MASP-3(gene name synonym)|uniprotkb:Complement-activating component of Ra-reactive factor(gene name synonym)|uniprotkb:Mannose-binding lectin-associated serine protease 1(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Jacquet et al. (2013)	imex:IM-29091|pubmed:23460739	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27034879|imex:IM-29091-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000203710(gene)|go:"GO:0001855"(complement component C4b binding)|go:"GO:0001861"(complement component C4b receptor activity)|go:"GO:0001970"(positive regulation of activation of membrane attack complex)|go:"GO:0001971"(negative regulation of activation of membrane attack complex)|go:"GO:0002430"(complement receptor mediated signaling pathway)|go:"GO:0002435"(immune complex clearance by erythrocytes)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0004877"(complement component C3b receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005856"(cytoskeleton)|ensembl:ENST00000367051(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|ensembl:ENST00000367053(transcript)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0006958"(complement activation, classical pathway)|ensembl:ENST00000400960(transcript)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0001618"(virus receptor activity)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0001851"(complement component C3b binding)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045916"(negative regulation of complement activation)|go:"GO:0045918"(negative regulation of cytolysis)|go:"GO:0045957"(negative regulation of complement activation, alternative pathway)|go:"GO:0045959"(negative regulation of complement activation, classical pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:1900004"(negative regulation of serine-type endopeptidase activity)|go:"GO:1900005"(positive regulation of serine-type endopeptidase activity)|go:"GO:1900099"(negative regulation of plasma cell differentiation)|go:"GO:1904669"(ATP export)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|rcsb pdb:1GKG|rcsb pdb:1GKN|rcsb pdb:1GOP|rcsb pdb:1PPQ|rcsb pdb:2MCY|rcsb pdb:2MCZ|rcsb pdb:2Q7Z|reactome:R-HSA-6798695|reactome:R-HSA-8877330|reactome:R-HSA-977606|rcsb pdb:5FO9|refseq:NP_000564.2|refseq:NP_000642.3	ensembl:ENSG00000127241(gene)|ensembl:ENST00000296280(transcript)|intact:EBI-6380536(isoform-parent)	-	-	-	figure legend:4B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/18	2021/07/15	rogid:gwNvQZmPMP1PCX8z/svSxkVBZt49606	rogid:tXsz/6dPTPLuD03oT3LxFm6yDA09606	rigid:gMezkIqmmTkgscuhtkMJj/JuUQw	false	his tag:c-c|mutation:1208-1208|sufficient binding region:42-1971	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P17927	uniprotkb:P48740-2	intact:EBI-2807625|ensembl:ENSP00000356018|ensembl:ENSP00000356020|ensembl:ENSP00000383744|uniprotkb:Q5SR43|uniprotkb:Q9UQV2|uniprotkb:Q5SR45|uniprotkb:Q16745|uniprotkb:Q16744	intact:EBI-26435098|ensembl:ENSP00000296280	psi-mi:cr1_human(display_long)|uniprotkb:CR1(gene name)|psi-mi:CR1(display_short)|uniprotkb:C3BR(gene name synonym)|uniprotkb:C3b/C4b receptor(gene name synonym)	psi-mi:p48740-2(display_long)|uniprotkb:Mannose-binding protein-associated serine protease(gene name synonym)|uniprotkb:Ra-reactive factor serine protease p100(gene name synonym)|uniprotkb:Serine protease 5(gene name synonym)|uniprotkb:MASP-3(isoform synonym)|uniprotkb:MASP1(gene name)|psi-mi:MASP1(display_short)|uniprotkb:CRARF(gene name synonym)|uniprotkb:CRARF1(gene name synonym)|uniprotkb:PRSS5(gene name synonym)|uniprotkb:Complement factor MASP-3(gene name synonym)|uniprotkb:Complement-activating component of Ra-reactive factor(gene name synonym)|uniprotkb:Mannose-binding lectin-associated serine protease 1(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Jacquet et al. (2013)	imex:IM-29091|pubmed:23460739	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27034921|imex:IM-29091-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000203710(gene)|go:"GO:0001855"(complement component C4b binding)|go:"GO:0001861"(complement component C4b receptor activity)|go:"GO:0001970"(positive regulation of activation of membrane attack complex)|go:"GO:0001971"(negative regulation of activation of membrane attack complex)|go:"GO:0002430"(complement receptor mediated signaling pathway)|go:"GO:0002435"(immune complex clearance by erythrocytes)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0004877"(complement component C3b receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005856"(cytoskeleton)|ensembl:ENST00000367051(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|ensembl:ENST00000367053(transcript)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0006958"(complement activation, classical pathway)|ensembl:ENST00000400960(transcript)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0001618"(virus receptor activity)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0001851"(complement component C3b binding)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045916"(negative regulation of complement activation)|go:"GO:0045918"(negative regulation of cytolysis)|go:"GO:0045957"(negative regulation of complement activation, alternative pathway)|go:"GO:0045959"(negative regulation of complement activation, classical pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:1900004"(negative regulation of serine-type endopeptidase activity)|go:"GO:1900005"(positive regulation of serine-type endopeptidase activity)|go:"GO:1900099"(negative regulation of plasma cell differentiation)|go:"GO:1904669"(ATP export)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|rcsb pdb:1GKG|rcsb pdb:1GKN|rcsb pdb:1GOP|rcsb pdb:1PPQ|rcsb pdb:2MCY|rcsb pdb:2MCZ|rcsb pdb:2Q7Z|reactome:R-HSA-6798695|reactome:R-HSA-8877330|reactome:R-HSA-977606|rcsb pdb:5FO9|refseq:NP_000564.2|refseq:NP_000642.3	ensembl:ENSG00000127241(gene)|ensembl:ENST00000296280(transcript)|intact:EBI-6380536(isoform-parent)	-	-	-	figure legend:4A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/18	2021/07/15	rogid:gwNvQZmPMP1PCX8z/svSxkVBZt49606	rogid:tXsz/6dPTPLuD03oT3LxFm6yDA09606	rigid:p65B4H2Q4XppL2V4ca2AAmxES6A	false	his tag:c-c|mutation:1208-1208|sufficient binding region:42-1971	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P17927	uniprotkb:P11226	intact:EBI-2807625|ensembl:ENSP00000356018|ensembl:ENSP00000356020|ensembl:ENSP00000383744|uniprotkb:Q5SR43|uniprotkb:Q9UQV2|uniprotkb:Q5SR45|uniprotkb:Q16745|uniprotkb:Q16744	intact:EBI-5325353|ensembl:ENSP00000363079|ensembl:ENSP00000502615|ensembl:ENSP00000502789|uniprotkb:Q4VB12|uniprotkb:Q4VB13|uniprotkb:Q86SI4|uniprotkb:Q96KE4|uniprotkb:Q96TF7|uniprotkb:Q96TF8|uniprotkb:Q96TF9|uniprotkb:Q4VB14|uniprotkb:Q5SQS3	psi-mi:cr1_human(display_long)|uniprotkb:CR1(gene name)|psi-mi:CR1(display_short)|uniprotkb:C3BR(gene name synonym)|uniprotkb:C3b/C4b receptor(gene name synonym)	psi-mi:mbl2_human(display_long)|uniprotkb:MBL2(gene name)|psi-mi:MBL2(display_short)|uniprotkb:COLEC1(gene name synonym)|uniprotkb:MBL(gene name synonym)|uniprotkb:Collectin-1(gene name synonym)|uniprotkb:MBP1(gene name synonym)|uniprotkb:Mannan-binding protein(gene name synonym)|uniprotkb:Mannose-binding lectin(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Jacquet et al. (2013)	imex:IM-29091|pubmed:23460739	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27034921|imex:IM-29091-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000203710(gene)|go:"GO:0001855"(complement component C4b binding)|go:"GO:0001861"(complement component C4b receptor activity)|go:"GO:0001970"(positive regulation of activation of membrane attack complex)|go:"GO:0001971"(negative regulation of activation of membrane attack complex)|go:"GO:0002430"(complement receptor mediated signaling pathway)|go:"GO:0002435"(immune complex clearance by erythrocytes)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0004877"(complement component C3b receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005856"(cytoskeleton)|ensembl:ENST00000367051(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|ensembl:ENST00000367053(transcript)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0006958"(complement activation, classical pathway)|ensembl:ENST00000400960(transcript)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0001618"(virus receptor activity)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0001851"(complement component C3b binding)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045916"(negative regulation of complement activation)|go:"GO:0045918"(negative regulation of cytolysis)|go:"GO:0045957"(negative regulation of complement activation, alternative pathway)|go:"GO:0045959"(negative regulation of complement activation, classical pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:1900004"(negative regulation of serine-type endopeptidase activity)|go:"GO:1900005"(positive regulation of serine-type endopeptidase activity)|go:"GO:1900099"(negative regulation of plasma cell differentiation)|go:"GO:1904669"(ATP export)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|rcsb pdb:1GKG|rcsb pdb:1GKN|rcsb pdb:1GOP|rcsb pdb:1PPQ|rcsb pdb:2MCY|rcsb pdb:2MCZ|rcsb pdb:2Q7Z|reactome:R-HSA-6798695|reactome:R-HSA-8877330|reactome:R-HSA-977606|rcsb pdb:5FO9|refseq:NP_000564.2|refseq:NP_000642.3	ensembl:ENSG00000165471(gene)|ensembl:ENST00000373968(transcript)|ensembl:ENST00000674931(transcript)|ensembl:ENST00000675947(transcript)|go:"GO:0001867"(complement activation, lectin pathway)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005537"(mannose binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0006953"(acute-phase response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008228"(opsonization)|go:"GO:0009986"(cell surface)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048525"(negative regulation of viral process)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR001304(C-type lectin)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR016186(C-type lectin-like)|refseq:XP_011538118.1|interpro:IPR018378|interpro:IPR033990|interpro:IPR037570|rcsb pdb:1HUP|interpro:IPR016187(C-type lectin fold)|reactome:R-HSA-166662|reactome:R-HSA-166663|refseq:NP_000233.1|refseq:XP_006717924.1|dip:DIP-61381N	-	-	-	figure legend:4A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/18	2021/07/15	rogid:gwNvQZmPMP1PCX8z/svSxkVBZt49606	rogid:uo0RM88uw3otObIVnOhUcOfW8yo9606	rigid:p65B4H2Q4XppL2V4ca2AAmxES6A	false	his tag:c-c|mutation:1208-1208|sufficient binding region:42-1971	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P17927	uniprotkb:P48740-2	intact:EBI-2807625|ensembl:ENSP00000356018|ensembl:ENSP00000356020|ensembl:ENSP00000383744|uniprotkb:Q5SR43|uniprotkb:Q9UQV2|uniprotkb:Q5SR45|uniprotkb:Q16745|uniprotkb:Q16744	intact:EBI-26435098|ensembl:ENSP00000296280	psi-mi:cr1_human(display_long)|uniprotkb:CR1(gene name)|psi-mi:CR1(display_short)|uniprotkb:C3BR(gene name synonym)|uniprotkb:C3b/C4b receptor(gene name synonym)	psi-mi:p48740-2(display_long)|uniprotkb:Mannose-binding protein-associated serine protease(gene name synonym)|uniprotkb:Ra-reactive factor serine protease p100(gene name synonym)|uniprotkb:Serine protease 5(gene name synonym)|uniprotkb:MASP-3(isoform synonym)|uniprotkb:MASP1(gene name)|psi-mi:MASP1(display_short)|uniprotkb:CRARF(gene name synonym)|uniprotkb:CRARF1(gene name synonym)|uniprotkb:PRSS5(gene name synonym)|uniprotkb:Complement factor MASP-3(gene name synonym)|uniprotkb:Complement-activating component of Ra-reactive factor(gene name synonym)|uniprotkb:Mannose-binding lectin-associated serine protease 1(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Jacquet et al. (2013)	imex:IM-29091|pubmed:23460739	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27034954|imex:IM-29091-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000203710(gene)|go:"GO:0001855"(complement component C4b binding)|go:"GO:0001861"(complement component C4b receptor activity)|go:"GO:0001970"(positive regulation of activation of membrane attack complex)|go:"GO:0001971"(negative regulation of activation of membrane attack complex)|go:"GO:0002430"(complement receptor mediated signaling pathway)|go:"GO:0002435"(immune complex clearance by erythrocytes)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0004877"(complement component C3b receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005856"(cytoskeleton)|ensembl:ENST00000367051(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|ensembl:ENST00000367053(transcript)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0006958"(complement activation, classical pathway)|ensembl:ENST00000400960(transcript)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0001618"(virus receptor activity)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0001851"(complement component C3b binding)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045916"(negative regulation of complement activation)|go:"GO:0045918"(negative regulation of cytolysis)|go:"GO:0045957"(negative regulation of complement activation, alternative pathway)|go:"GO:0045959"(negative regulation of complement activation, classical pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:1900004"(negative regulation of serine-type endopeptidase activity)|go:"GO:1900005"(positive regulation of serine-type endopeptidase activity)|go:"GO:1900099"(negative regulation of plasma cell differentiation)|go:"GO:1904669"(ATP export)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|rcsb pdb:1GKG|rcsb pdb:1GKN|rcsb pdb:1GOP|rcsb pdb:1PPQ|rcsb pdb:2MCY|rcsb pdb:2MCZ|rcsb pdb:2Q7Z|reactome:R-HSA-6798695|reactome:R-HSA-8877330|reactome:R-HSA-977606|rcsb pdb:5FO9|refseq:NP_000564.2|refseq:NP_000642.3	ensembl:ENSG00000127241(gene)|ensembl:ENST00000296280(transcript)|intact:EBI-6380536(isoform-parent)	-	-	-	figure legend:4A|comment:"CR1:The expression system and presence/absence of a His-tag is not stated."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:0.37x10^-9(molar)	2020/12/18	2021/07/15	rogid:gwNvQZmPMP1PCX8z/svSxkVBZt49606	rogid:tXsz/6dPTPLuD03oT3LxFm6yDA09606	rigid:p65B4H2Q4XppL2V4ca2AAmxES6A	false	his tag:c-c|sufficient binding region:1395-1969	-	1	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P17927	uniprotkb:P11226	intact:EBI-2807625|ensembl:ENSP00000356018|ensembl:ENSP00000356020|ensembl:ENSP00000383744|uniprotkb:Q5SR43|uniprotkb:Q9UQV2|uniprotkb:Q5SR45|uniprotkb:Q16745|uniprotkb:Q16744	intact:EBI-5325353|ensembl:ENSP00000363079|ensembl:ENSP00000502615|ensembl:ENSP00000502789|uniprotkb:Q4VB12|uniprotkb:Q4VB13|uniprotkb:Q86SI4|uniprotkb:Q96KE4|uniprotkb:Q96TF7|uniprotkb:Q96TF8|uniprotkb:Q96TF9|uniprotkb:Q4VB14|uniprotkb:Q5SQS3	psi-mi:cr1_human(display_long)|uniprotkb:CR1(gene name)|psi-mi:CR1(display_short)|uniprotkb:C3BR(gene name synonym)|uniprotkb:C3b/C4b receptor(gene name synonym)	psi-mi:mbl2_human(display_long)|uniprotkb:MBL2(gene name)|psi-mi:MBL2(display_short)|uniprotkb:COLEC1(gene name synonym)|uniprotkb:MBL(gene name synonym)|uniprotkb:Collectin-1(gene name synonym)|uniprotkb:MBP1(gene name synonym)|uniprotkb:Mannan-binding protein(gene name synonym)|uniprotkb:Mannose-binding lectin(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Jacquet et al. (2013)	imex:IM-29091|pubmed:23460739	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27034954|imex:IM-29091-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000203710(gene)|go:"GO:0001855"(complement component C4b binding)|go:"GO:0001861"(complement component C4b receptor activity)|go:"GO:0001970"(positive regulation of activation of membrane attack complex)|go:"GO:0001971"(negative regulation of activation of membrane attack complex)|go:"GO:0002430"(complement receptor mediated signaling pathway)|go:"GO:0002435"(immune complex clearance by erythrocytes)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0004877"(complement component C3b receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005856"(cytoskeleton)|ensembl:ENST00000367051(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|ensembl:ENST00000367053(transcript)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0006958"(complement activation, classical pathway)|ensembl:ENST00000400960(transcript)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0001618"(virus receptor activity)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0001851"(complement component C3b binding)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045916"(negative regulation of complement activation)|go:"GO:0045918"(negative regulation of cytolysis)|go:"GO:0045957"(negative regulation of complement activation, alternative pathway)|go:"GO:0045959"(negative regulation of complement activation, classical pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:1900004"(negative regulation of serine-type endopeptidase activity)|go:"GO:1900005"(positive regulation of serine-type endopeptidase activity)|go:"GO:1900099"(negative regulation of plasma cell differentiation)|go:"GO:1904669"(ATP export)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|rcsb pdb:1GKG|rcsb pdb:1GKN|rcsb pdb:1GOP|rcsb pdb:1PPQ|rcsb pdb:2MCY|rcsb pdb:2MCZ|rcsb pdb:2Q7Z|reactome:R-HSA-6798695|reactome:R-HSA-8877330|reactome:R-HSA-977606|rcsb pdb:5FO9|refseq:NP_000564.2|refseq:NP_000642.3	ensembl:ENSG00000165471(gene)|ensembl:ENST00000373968(transcript)|ensembl:ENST00000674931(transcript)|ensembl:ENST00000675947(transcript)|go:"GO:0001867"(complement activation, lectin pathway)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005537"(mannose binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0006953"(acute-phase response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008228"(opsonization)|go:"GO:0009986"(cell surface)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048525"(negative regulation of viral process)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR001304(C-type lectin)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR016186(C-type lectin-like)|refseq:XP_011538118.1|interpro:IPR018378|interpro:IPR033990|interpro:IPR037570|rcsb pdb:1HUP|interpro:IPR016187(C-type lectin fold)|reactome:R-HSA-166662|reactome:R-HSA-166663|refseq:NP_000233.1|refseq:XP_006717924.1|dip:DIP-61381N	-	-	-	figure legend:4A|comment:"CR1:The expression system and presence/absence of a His-tag is not stated."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:0.37x10^-9(molar)	2020/12/18	2021/07/15	rogid:gwNvQZmPMP1PCX8z/svSxkVBZt49606	rogid:uo0RM88uw3otObIVnOhUcOfW8yo9606	rigid:p65B4H2Q4XppL2V4ca2AAmxES6A	false	his tag:c-c|sufficient binding region:1395-1969	-	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P17927	uniprotkb:Q15485	intact:EBI-2807625|ensembl:ENSP00000356018|ensembl:ENSP00000356020|ensembl:ENSP00000383744|uniprotkb:Q5SR43|uniprotkb:Q9UQV2|uniprotkb:Q5SR45|uniprotkb:Q16745|uniprotkb:Q16744	intact:EBI-7468784|uniprotkb:A6NFG7|uniprotkb:Q9UC57|uniprotkb:Q6IS69|intact:MINT-5223224|uniprotkb:Q7M4P4|uniprotkb:A8K478|ensembl:ENSP00000291744	psi-mi:cr1_human(display_long)|uniprotkb:CR1(gene name)|psi-mi:CR1(display_short)|uniprotkb:C3BR(gene name synonym)|uniprotkb:C3b/C4b receptor(gene name synonym)	psi-mi:fcn2_human(display_long)|uniprotkb:FCN2(gene name)|psi-mi:FCN2(display_short)|uniprotkb:FCNL(gene name synonym)|uniprotkb:Ficolin-B(gene name synonym)|uniprotkb:Ficolin-beta(gene name synonym)|uniprotkb:L-ficolin(gene name synonym)|uniprotkb:Collagen/fibrinogen domain-containing protein 2(gene name synonym)|uniprotkb:Serum lectin p35(gene name synonym)|uniprotkb:37 kDa elastin-binding protein(gene name synonym)|uniprotkb:EBP-37(gene name synonym)|uniprotkb:Hucolin(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Jacquet et al. (2013)	imex:IM-29091|pubmed:23460739	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27034965|imex:IM-29091-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000203710(gene)|go:"GO:0001855"(complement component C4b binding)|go:"GO:0001861"(complement component C4b receptor activity)|go:"GO:0001970"(positive regulation of activation of membrane attack complex)|go:"GO:0001971"(negative regulation of activation of membrane attack complex)|go:"GO:0002430"(complement receptor mediated signaling pathway)|go:"GO:0002435"(immune complex clearance by erythrocytes)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0004877"(complement component C3b receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005856"(cytoskeleton)|ensembl:ENST00000367051(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|ensembl:ENST00000367053(transcript)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0006958"(complement activation, classical pathway)|ensembl:ENST00000400960(transcript)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0001618"(virus receptor activity)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0001851"(complement component C3b binding)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045916"(negative regulation of complement activation)|go:"GO:0045918"(negative regulation of cytolysis)|go:"GO:0045957"(negative regulation of complement activation, alternative pathway)|go:"GO:0045959"(negative regulation of complement activation, classical pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:1900004"(negative regulation of serine-type endopeptidase activity)|go:"GO:1900005"(positive regulation of serine-type endopeptidase activity)|go:"GO:1900099"(negative regulation of plasma cell differentiation)|go:"GO:1904669"(ATP export)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|rcsb pdb:1GKG|rcsb pdb:1GKN|rcsb pdb:1GOP|rcsb pdb:1PPQ|rcsb pdb:2MCY|rcsb pdb:2MCZ|rcsb pdb:2Q7Z|reactome:R-HSA-6798695|reactome:R-HSA-8877330|reactome:R-HSA-977606|rcsb pdb:5FO9|refseq:NP_000564.2|refseq:NP_000642.3	refseq:NP_004099.2|refseq:NP_056652.1|ensembl:ENSG00000160339(gene)|ensembl:ENST00000291744(transcript)|go:"GO:0001867"(complement activation, lectin pathway)|go:"GO:0003823"(antigen binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0008228"(opsonization)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0043654"(recognition of apoptotic cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0097367"(carbohydrate derivative binding)|go:"GO:2001065"(mannan binding)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|interpro:IPR036056|mint:Q15485|rcsb pdb:2J0G|rcsb pdb:2J0H|rcsb pdb:2J0Y|rcsb pdb:2J1G|rcsb pdb:2J2P|rcsb pdb:2J3F|rcsb pdb:2J3G|rcsb pdb:2J3O|rcsb pdb:2J3U|rcsb pdb:2J61|rcsb pdb:4NYT|rcsb pdb:4R9J|rcsb pdb:4R9T|reactome:R-HSA-166662|reactome:R-HSA-166663|reactome:R-HSA-2855086	-	-	comment:mint|function:Calcium-dependent and GlcNAc-binding lectin. Enhanced phagocytosis of S.typhimurium by neutrophils, suggesting an opsonic effect via the collagen region	figure legend:4B|comment:"CR1:The expression system and presence/absence of a His-tag is not stated."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/18	2021/07/15	rogid:gwNvQZmPMP1PCX8z/svSxkVBZt49606	rogid:j6vRtYG3I6cn0c2TId/73bE/1To9606	rigid:gMezkIqmmTkgscuhtkMJj/JuUQw	false	his tag:c-c|sufficient binding region:1395-1969	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P17927	uniprotkb:P48740-2	intact:EBI-2807625|ensembl:ENSP00000356018|ensembl:ENSP00000356020|ensembl:ENSP00000383744|uniprotkb:Q5SR43|uniprotkb:Q9UQV2|uniprotkb:Q5SR45|uniprotkb:Q16745|uniprotkb:Q16744	intact:EBI-26435098|ensembl:ENSP00000296280	psi-mi:cr1_human(display_long)|uniprotkb:CR1(gene name)|psi-mi:CR1(display_short)|uniprotkb:C3BR(gene name synonym)|uniprotkb:C3b/C4b receptor(gene name synonym)	psi-mi:p48740-2(display_long)|uniprotkb:Mannose-binding protein-associated serine protease(gene name synonym)|uniprotkb:Ra-reactive factor serine protease p100(gene name synonym)|uniprotkb:Serine protease 5(gene name synonym)|uniprotkb:MASP-3(isoform synonym)|uniprotkb:MASP1(gene name)|psi-mi:MASP1(display_short)|uniprotkb:CRARF(gene name synonym)|uniprotkb:CRARF1(gene name synonym)|uniprotkb:PRSS5(gene name synonym)|uniprotkb:Complement factor MASP-3(gene name synonym)|uniprotkb:Complement-activating component of Ra-reactive factor(gene name synonym)|uniprotkb:Mannose-binding lectin-associated serine protease 1(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Jacquet et al. (2013)	imex:IM-29091|pubmed:23460739	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27034965|imex:IM-29091-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000203710(gene)|go:"GO:0001855"(complement component C4b binding)|go:"GO:0001861"(complement component C4b receptor activity)|go:"GO:0001970"(positive regulation of activation of membrane attack complex)|go:"GO:0001971"(negative regulation of activation of membrane attack complex)|go:"GO:0002430"(complement receptor mediated signaling pathway)|go:"GO:0002435"(immune complex clearance by erythrocytes)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0004877"(complement component C3b receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005856"(cytoskeleton)|ensembl:ENST00000367051(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|ensembl:ENST00000367053(transcript)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0006958"(complement activation, classical pathway)|ensembl:ENST00000400960(transcript)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0001618"(virus receptor activity)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0001851"(complement component C3b binding)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045916"(negative regulation of complement activation)|go:"GO:0045918"(negative regulation of cytolysis)|go:"GO:0045957"(negative regulation of complement activation, alternative pathway)|go:"GO:0045959"(negative regulation of complement activation, classical pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:1900004"(negative regulation of serine-type endopeptidase activity)|go:"GO:1900005"(positive regulation of serine-type endopeptidase activity)|go:"GO:1900099"(negative regulation of plasma cell differentiation)|go:"GO:1904669"(ATP export)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|rcsb pdb:1GKG|rcsb pdb:1GKN|rcsb pdb:1GOP|rcsb pdb:1PPQ|rcsb pdb:2MCY|rcsb pdb:2MCZ|rcsb pdb:2Q7Z|reactome:R-HSA-6798695|reactome:R-HSA-8877330|reactome:R-HSA-977606|rcsb pdb:5FO9|refseq:NP_000564.2|refseq:NP_000642.3	ensembl:ENSG00000127241(gene)|ensembl:ENST00000296280(transcript)|intact:EBI-6380536(isoform-parent)	-	-	-	figure legend:4B|comment:"CR1:The expression system and presence/absence of a His-tag is not stated."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/18	2021/07/15	rogid:gwNvQZmPMP1PCX8z/svSxkVBZt49606	rogid:tXsz/6dPTPLuD03oT3LxFm6yDA09606	rigid:gMezkIqmmTkgscuhtkMJj/JuUQw	false	his tag:c-c|sufficient binding region:1395-1969	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)