#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P49682 uniprotkb:Q9NPB9 intact:EBI-12836456|ensembl:ENSP00000362797|uniprotkb:B2R982|uniprotkb:O15185|uniprotkb:Q7Z710|uniprotkb:Q9P2T4|uniprotkb:Q9P2T5 intact:EBI-3914445|uniprotkb:B2R9U7|ensembl:ENSP00000249887 psi-mi:cxcr3_human(display_long)|uniprotkb:CXCR3(gene name)|psi-mi:CXCR3(display_short)|uniprotkb:CKR-L2(gene name synonym)|uniprotkb:G protein-coupled receptor 9(gene name synonym)|uniprotkb:GPR9(gene name synonym)|uniprotkb:Interferon-inducible protein 10 receptor(gene name synonym) psi-mi:ackr4_human(display_long)|uniprotkb:ACKR4(gene name)|psi-mi:ACKR4(display_short)|uniprotkb:C-C chemokine receptor type 11(gene name synonym)|uniprotkb:CC chemokine receptor-like 1(gene name synonym)|uniprotkb:CCBP2(gene name synonym)|uniprotkb:CCR11(gene name synonym)|uniprotkb:CCRL1(gene name synonym)|uniprotkb:CCX CKR(gene name synonym)|uniprotkb:VSHK1(gene name synonym) psi-mi:"MI:0055"(fluorescent resonance energy transfer) Vinet et al. (2013) imex:IM-28127|pubmed:23121557 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-25569746|imex:IM-28127-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0584"(fluorescence acceptor) psi-mi:"MI:0583"(fluorescence donor) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0038023"(signaling receptor activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0060326"(cell chemotaxis)|go:"GO:1900118"(negative regulation of execution phase of apoptosis)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000355(Chemokine receptor)|interpro:IPR004070(C-X-C chemokine receptor, type 3)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-HSA-380108|reactome:R-HSA-418594|go:"GO:0030155"(regulation of cell adhesion)|ensembl:ENSG00000186810(gene)|ensembl:ENST00000373693(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002685"(regulation of leukocyte migration)|go:"GO:0004950"(chemokine receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0016494"(C-X-C chemokine receptor activity)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019956"(chemokine binding)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0019958"(C-X-C chemokine binding)|refseq:NP_001136269.1|refseq:NP_001495.1|refseq:XP_016884924.1|dip:DIP-5891N refseq:NP_057641.1|refseq:NP_848540.1|ensembl:ENSG00000129048(gene)|ensembl:ENST00000249887(transcript)|go:"GO:0004950"(chemokine receptor activity)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0006955"(immune response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0055037"(recycling endosome)|go:"GO:0060326"(cell chemotaxis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000355(Chemokine receptor)|interpro:IPR005383(C-C chemokine receptor, type 11)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-HSA-380108|dip:DIP-5918N - - - figure legend:Fig. 3A, 3B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2020/04/23 2020/04/23 rogid:P9WxnLkV6IH50a6feWDd6KsoNlA9606 rogid:4hT5Tu8UmQCNU/yz5vIWYQXjEis9606 rigid:GBytAfZjKr+Any6qqPSkNujvbg4 false venus fluorescent protein tag:c-c cyan fluorescent protein tag:c-c - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:P49682 uniprotkb:P49682 intact:EBI-12836456|ensembl:ENSP00000362797|uniprotkb:B2R982|uniprotkb:O15185|uniprotkb:Q7Z710|uniprotkb:Q9P2T4|uniprotkb:Q9P2T5 intact:EBI-12836456|ensembl:ENSP00000362797|uniprotkb:B2R982|uniprotkb:O15185|uniprotkb:Q7Z710|uniprotkb:Q9P2T4|uniprotkb:Q9P2T5 psi-mi:cxcr3_human(display_long)|uniprotkb:CXCR3(gene name)|psi-mi:CXCR3(display_short)|uniprotkb:CKR-L2(gene name synonym)|uniprotkb:G protein-coupled receptor 9(gene name synonym)|uniprotkb:GPR9(gene name synonym)|uniprotkb:Interferon-inducible protein 10 receptor(gene name synonym) psi-mi:cxcr3_human(display_long)|uniprotkb:CXCR3(gene name)|psi-mi:CXCR3(display_short)|uniprotkb:CKR-L2(gene name synonym)|uniprotkb:G protein-coupled receptor 9(gene name synonym)|uniprotkb:GPR9(gene name synonym)|uniprotkb:Interferon-inducible protein 10 receptor(gene name synonym) psi-mi:"MI:0055"(fluorescent resonance energy transfer) Vinet et al. (2013) imex:IM-28127|pubmed:23121557 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-25569789|imex:IM-28127-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0584"(fluorescence acceptor) psi-mi:"MI:0583"(fluorescence donor) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0038023"(signaling receptor activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0060326"(cell chemotaxis)|go:"GO:1900118"(negative regulation of execution phase of apoptosis)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000355(Chemokine receptor)|interpro:IPR004070(C-X-C chemokine receptor, type 3)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-HSA-380108|reactome:R-HSA-418594|go:"GO:0030155"(regulation of cell adhesion)|ensembl:ENSG00000186810(gene)|ensembl:ENST00000373693(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002685"(regulation of leukocyte migration)|go:"GO:0004950"(chemokine receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0016494"(C-X-C chemokine receptor activity)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019956"(chemokine binding)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0019958"(C-X-C chemokine binding)|refseq:NP_001136269.1|refseq:NP_001495.1|refseq:XP_016884924.1|dip:DIP-5891N go:"GO:0038023"(signaling receptor activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0060326"(cell chemotaxis)|go:"GO:1900118"(negative regulation of execution phase of apoptosis)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000355(Chemokine receptor)|interpro:IPR004070(C-X-C chemokine receptor, type 3)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-HSA-380108|reactome:R-HSA-418594|go:"GO:0030155"(regulation of cell adhesion)|ensembl:ENSG00000186810(gene)|ensembl:ENST00000373693(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002685"(regulation of leukocyte migration)|go:"GO:0004950"(chemokine receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0016494"(C-X-C chemokine receptor activity)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019956"(chemokine binding)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0019958"(C-X-C chemokine binding)|refseq:NP_001136269.1|refseq:NP_001495.1|refseq:XP_016884924.1|dip:DIP-5891N - - - figure legend:Fig. 3A, 3B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2020/04/23 2020/04/23 rogid:P9WxnLkV6IH50a6feWDd6KsoNlA9606 rogid:P9WxnLkV6IH50a6feWDd6KsoNlA9606 rigid:jeB/eTdYkWzl1NOgaTMlyvAiIGU false venus fluorescent protein tag:c-c cyan fluorescent protein tag:c-c - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:P51681 uniprotkb:P51681 intact:EBI-489374|uniprotkb:O14692|uniprotkb:O14693|uniprotkb:O14695|uniprotkb:O14696|uniprotkb:O14697|uniprotkb:O14698|uniprotkb:O14699|uniprotkb:O14700|uniprotkb:O14701|uniprotkb:O14702|uniprotkb:O14703|uniprotkb:O14704|uniprotkb:O14705|uniprotkb:O14706|uniprotkb:O14707|uniprotkb:O14708|uniprotkb:O15538|uniprotkb:Q9UPA4|ensembl:ENSP00000292303|ensembl:ENSP00000404881 intact:EBI-489374|uniprotkb:O14692|uniprotkb:O14693|uniprotkb:O14695|uniprotkb:O14696|uniprotkb:O14697|uniprotkb:O14698|uniprotkb:O14699|uniprotkb:O14700|uniprotkb:O14701|uniprotkb:O14702|uniprotkb:O14703|uniprotkb:O14704|uniprotkb:O14705|uniprotkb:O14706|uniprotkb:O14707|uniprotkb:O14708|uniprotkb:O15538|uniprotkb:Q9UPA4|ensembl:ENSP00000292303|ensembl:ENSP00000404881 psi-mi:ccr5_human(display_long)|uniprotkb:HIV-1 fusion coreceptor(gene name synonym)|uniprotkb:CHEMR13(gene name synonym)|uniprotkb:CCR5(gene name)|psi-mi:CCR5(display_short)|uniprotkb:CMKBR5(gene name synonym) psi-mi:ccr5_human(display_long)|uniprotkb:HIV-1 fusion coreceptor(gene name synonym)|uniprotkb:CHEMR13(gene name synonym)|uniprotkb:CCR5(gene name)|psi-mi:CCR5(display_short)|uniprotkb:CMKBR5(gene name synonym) psi-mi:"MI:0055"(fluorescent resonance energy transfer) Vinet et al. (2013) imex:IM-28127|pubmed:23121557 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-25569798|imex:IM-28127-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0583"(fluorescence donor) psi-mi:"MI:0584"(fluorescence acceptor) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0019722"(calcium-mediated signaling)|refseq:NP_000570.1|refseq:NP_001093638.1|ensembl:ENSG00000160791(gene)|ensembl:ENST00000292303(transcript)|ensembl:ENST00000445772(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001618"(virus receptor activity)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0003779"(actin binding)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004950"(chemokine receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0014808"(release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016493"(C-C chemokine receptor activity)|rcsb pdb:4MBS|rcsb pdb:5UIW|rcsb pdb:5YD3|rcsb pdb:5YD4|rcsb pdb:5YD5|rcsb pdb:5YY4|rcsb pdb:6FGP|rcsb pdb:6MEO|rcsb pdb:6MET|rcsb pdb:7O7F|reactome:R-HSA-173107|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:2RRS|go:"GO:0023052"(signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071791"("chemokine (C-C motif) ligand 5 binding")|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000355(Chemokine receptor)|interpro:IPR002240(C-C chemokine receptor, type 5)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P51681|rcsb pdb:1ND8|rcsb pdb:1NE0|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:2L87|go:"GO:0019957"(C-C chemokine binding)|rcsb pdb:2MZX|rcsb pdb:2RLL|dip:DIP-5866N go:"GO:0019722"(calcium-mediated signaling)|refseq:NP_000570.1|refseq:NP_001093638.1|ensembl:ENSG00000160791(gene)|ensembl:ENST00000292303(transcript)|ensembl:ENST00000445772(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001618"(virus receptor activity)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0003779"(actin binding)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004950"(chemokine receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0014808"(release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016493"(C-C chemokine receptor activity)|rcsb pdb:4MBS|rcsb pdb:5UIW|rcsb pdb:5YD3|rcsb pdb:5YD4|rcsb pdb:5YD5|rcsb pdb:5YY4|rcsb pdb:6FGP|rcsb pdb:6MEO|rcsb pdb:6MET|rcsb pdb:7O7F|reactome:R-HSA-173107|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:2RRS|go:"GO:0023052"(signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071791"("chemokine (C-C motif) ligand 5 binding")|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000355(Chemokine receptor)|interpro:IPR002240(C-C chemokine receptor, type 5)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P51681|rcsb pdb:1ND8|rcsb pdb:1NE0|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:2L87|go:"GO:0019957"(C-C chemokine binding)|rcsb pdb:2MZX|rcsb pdb:2RLL|dip:DIP-5866N - - - figure legend:Fig. 3B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2020/04/23 2020/04/23 rogid:qpXGapPDi9co6c1kf2NgfM1qkA89606 rogid:qpXGapPDi9co6c1kf2NgfM1qkA89606 rigid:zUCEJrSLDNqZL/slT5Aj4wl+Ucc false venus fluorescent protein tag:?-? cyan fluorescent protein tag:?-? - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence)