#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q15139 uniprotkb:P53367 intact:EBI-1181072|uniprotkb:A6NL64|uniprotkb:B2RAF6|ensembl:ENSP00000333568|ensembl:ENSP00000482645 intact:EBI-2808808|uniprotkb:Q9Y2X6|uniprotkb:Q3SYL4|uniprotkb:B4DS69|uniprotkb:Q2M2X4|ensembl:ENSP00000296557|ensembl:ENSP00000395083 psi-mi:kpcd1_human(display_long)|uniprotkb:nPKC-D1(gene name synonym)|uniprotkb:Protein kinase D(gene name synonym)|uniprotkb:Protein kinase C mu type(gene name synonym)|uniprotkb:nPKC-mu(gene name synonym)|uniprotkb:PRKD1(gene name)|psi-mi:PRKD1(display_short)|uniprotkb:PKD(gene name synonym)|uniprotkb:PKD1(gene name synonym)|uniprotkb:PRKCM(gene name synonym) psi-mi:arfp1_human(display_long)|uniprotkb:ARFIP1(gene name)|psi-mi:ARFIP1(display_short)|uniprotkb:ADP-ribosylation factor-interacting protein 1(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Gehart et al. (2012) pubmed:22981988|imex:IM-27889 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-25506844|imex:IM-27889-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002733.2|ensembl:ENSG00000184304(gene)|ensembl:ENST00000331968(transcript)|ensembl:ENST00000616995(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0001525"(angiogenesis)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007030"(Golgi organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010837"(regulation of keratinocyte proliferation)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030154"(cell differentiation)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032793"(positive regulation of CREB transcription factor activity)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0038033"(positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048193"(Golgi vesicle transport)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0071447"(cellular response to hydroperoxide)|go:"GO:0089700"(protein kinase D signaling)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015727(Protein kinase C mu-related)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|go:"GO:0006915"(apoptotic process)|reactome:R-HSA-1660661|interpro:IPR020454|dip:DIP-38481N refseq:XP_011530171.1|refseq:NP_001020764.1|refseq:NP_001020766.1|refseq:NP_055262.1|refseq:XP_011530172.1|refseq:NP_001274360.1|refseq:NP_001274361.1|refseq:NP_001274362.1|ensembl:ENSG00000164144(gene)|ensembl:ENST00000353617(transcript)|ensembl:ENST00000451320(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0034315"(regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:1905280"(negative regulation of retrograde transport, endosome to Golgi)|interpro:IPR010504(Arfaptin-like)|interpro:IPR027267|interpro:IPR030793|interpro:IPR030798|mint:P53367 go:"GO:0016301"(kinase activity)|go:"GO:0006468"(protein phosphorylation) - - figure legend:1b|antagonist:"PKD inhibitor Gö6976 (CHEBI:51913)"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/04/07 2020/04/29 rogid:L92XaEb6RJRv/HwB9Z56hiEl3jI9606 rogid:KEZ1eqEIdGfgFYIlc3WlNvqg9/89606 rigid:BHXeJO8BJGLCFh3Ru2Wet9OWp8U false - mutation disrupting interaction rate:132-132|glutathione s tranferase tag:n-n|32p radiolabel:?-? - - psi-mi:"MI:0833"(autoradiography) psi-mi:"MI:0833"(autoradiography) uniprotkb:Q15139 uniprotkb:P53367 intact:EBI-1181072|uniprotkb:A6NL64|uniprotkb:B2RAF6|ensembl:ENSP00000333568|ensembl:ENSP00000482645 intact:EBI-2808808|uniprotkb:Q9Y2X6|uniprotkb:Q3SYL4|uniprotkb:B4DS69|uniprotkb:Q2M2X4|ensembl:ENSP00000296557|ensembl:ENSP00000395083 psi-mi:kpcd1_human(display_long)|uniprotkb:nPKC-D1(gene name synonym)|uniprotkb:Protein kinase D(gene name synonym)|uniprotkb:Protein kinase C mu type(gene name synonym)|uniprotkb:nPKC-mu(gene name synonym)|uniprotkb:PRKD1(gene name)|psi-mi:PRKD1(display_short)|uniprotkb:PKD(gene name synonym)|uniprotkb:PKD1(gene name synonym)|uniprotkb:PRKCM(gene name synonym) psi-mi:arfp1_human(display_long)|uniprotkb:ARFIP1(gene name)|psi-mi:ARFIP1(display_short)|uniprotkb:ADP-ribosylation factor-interacting protein 1(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Gehart et al. (2012) pubmed:22981988|imex:IM-27889 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-25507053|imex:IM-27889-3 - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002733.2|ensembl:ENSG00000184304(gene)|ensembl:ENST00000331968(transcript)|ensembl:ENST00000616995(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0001525"(angiogenesis)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007030"(Golgi organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010837"(regulation of keratinocyte proliferation)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030154"(cell differentiation)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032793"(positive regulation of CREB transcription factor activity)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0038033"(positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048193"(Golgi vesicle transport)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0071447"(cellular response to hydroperoxide)|go:"GO:0089700"(protein kinase D signaling)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015727(Protein kinase C mu-related)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|go:"GO:0006915"(apoptotic process)|reactome:R-HSA-1660661|interpro:IPR020454|dip:DIP-38481N refseq:XP_011530171.1|refseq:NP_001020764.1|refseq:NP_001020766.1|refseq:NP_055262.1|refseq:XP_011530172.1|refseq:NP_001274360.1|refseq:NP_001274361.1|refseq:NP_001274362.1|ensembl:ENSG00000164144(gene)|ensembl:ENST00000353617(transcript)|ensembl:ENST00000451320(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0034315"(regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:1905280"(negative regulation of retrograde transport, endosome to Golgi)|interpro:IPR010504(Arfaptin-like)|interpro:IPR027267|interpro:IPR030793|interpro:IPR030798|mint:P53367 go:"GO:0006468"(protein phosphorylation)|go:"GO:0016301"(kinase activity) - - figure legend:1c|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/04/07 2020/04/23 rogid:L92XaEb6RJRv/HwB9Z56hiEl3jI9606 rogid:KEZ1eqEIdGfgFYIlc3WlNvqg9/89606 rigid:BHXeJO8BJGLCFh3Ru2Wet9OWp8U false - O-phospho-L-serine:132-132|glutathione s tranferase tag:n-n|mutation disrupting interaction rate:132-132 - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P84077 uniprotkb:P53367 intact:EBI-447171|uniprotkb:P10947|uniprotkb:P32889|ensembl:ENSP00000272102|ensembl:ENSP00000440005|ensembl:ENSP00000442980 intact:EBI-2808808|uniprotkb:Q9Y2X6|uniprotkb:Q3SYL4|uniprotkb:B4DS69|uniprotkb:Q2M2X4|ensembl:ENSP00000296557|ensembl:ENSP00000395083 psi-mi:arf1_human(display_long)|uniprotkb:ARF1(gene name)|psi-mi:ARF1(display_short) psi-mi:arfp1_human(display_long)|uniprotkb:ARFIP1(gene name)|psi-mi:ARFIP1(display_short)|uniprotkb:ADP-ribosylation factor-interacting protein 1(gene name synonym) psi-mi:"MI:0096"(pull down) Gehart et al. (2012) pubmed:22981988|imex:IM-27889 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-25507070|imex:IM-27889-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001019397.1|refseq:NP_001019398.1|refseq:NP_001019399.1|refseq:NP_001649.1|dip:DIP-31597N|ensembl:ENSG00000143761(gene)|ensembl:ENST00000272102(transcript)|ensembl:ENST00000540651(transcript)|ensembl:ENST00000541182(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0002090"(regulation of receptor internalization)|go:"GO:0003723"(RNA binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005770"(late endosome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007015"(actin filament organization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019003"(GDP binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030137"(COPI-coated vesicle)|go:"GO:0031252"(cell leading edge)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034315"(regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0043005"(neuron projection)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045956"(positive regulation of calcium ion-dependent exocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0055108"(Golgi to transport vesicle transport)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070142"(synaptic vesicle budding)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097212"(lysosomal membrane organization)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902307"(positive regulation of sodium ion transmembrane transport)|go:"GO:1902824"(positive regulation of late endosome to lysosome transport)|go:"GO:0034379"(very-low-density lipoprotein particle assembly)|go:"GO:1903725"(regulation of phospholipid metabolic process)|go:"GO:1990386"(mitotic cleavage furrow ingression)|go:"GO:1990583"(phospholipase D activator activity)|interpro:IPR005225(Small GTP-binding protein)|go:"GO:1902953"(positive regulation of ER to Golgi vesicle-mediated transport)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR027417|mint:P84077|rcsb pdb:1HUR|rcsb pdb:1RE0|rcsb pdb:1U81|rcsb pdb:3O47|rcsb pdb:4HMY|rcsb pdb:6CM9|rcsb pdb:6CRI|rcsb pdb:6D83|rcsb pdb:6D84|rcsb pdb:6DFF|rcsb pdb:6FAE|rcsb pdb:7MGE|reactome:R-HSA-1660499|reactome:R-HSA-1660514|reactome:R-HSA-167590|reactome:R-HSA-199992|reactome:R-HSA-2132295|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811438|reactome:R-HSA-8950505 refseq:XP_011530171.1|refseq:NP_001020764.1|refseq:NP_001020766.1|refseq:NP_055262.1|refseq:XP_011530172.1|refseq:NP_001274360.1|refseq:NP_001274361.1|refseq:NP_001274362.1|ensembl:ENSG00000164144(gene)|ensembl:ENST00000353617(transcript)|ensembl:ENST00000451320(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0034315"(regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:1905280"(negative regulation of retrograde transport, endosome to Golgi)|interpro:IPR010504(Arfaptin-like)|interpro:IPR027267|interpro:IPR030793|interpro:IPR030798|mint:P53367 - - - figure legend:3A S2C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/04/07 2020/04/15 rogid:zray9asm6VonxpuJpv0dRBspPt89606 rogid:KEZ1eqEIdGfgFYIlc3WlNvqg9/89606 rigid:Ycq6GBEk+6/8Q/oDkhmKqT5I8aQ false ha tag:n-n glutathione s tranferase tag:n-n|O-phospho-L-serine:132-132|mutation disrupting interaction strength:132-132|mutation with no effect:132-132 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P40616 uniprotkb:P53367 intact:EBI-1052746|uniprotkb:P80417|uniprotkb:Q53XB1|uniprotkb:B4DWW1|ensembl:ENSP00000261636|intact:EBI-11157530 intact:EBI-2808808|uniprotkb:Q9Y2X6|uniprotkb:Q3SYL4|uniprotkb:B4DS69|uniprotkb:Q2M2X4|ensembl:ENSP00000296557|ensembl:ENSP00000395083 psi-mi:arl1_human(display_long)|uniprotkb:ARL1(gene name)|psi-mi:ARL1(display_short) psi-mi:arfp1_human(display_long)|uniprotkb:ARFIP1(gene name)|psi-mi:ARFIP1(display_short)|uniprotkb:ADP-ribosylation factor-interacting protein 1(gene name synonym) psi-mi:"MI:0096"(pull down) Gehart et al. (2012) pubmed:22981988|imex:IM-27889 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-25568900|imex:IM-27889-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001168.1|ensembl:ENSG00000120805(gene)|ensembl:ENST00000261636(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007030"(Golgi organization)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0009404"(toxin metabolic process)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0046872"(metal ion binding)|go:"GO:0048193"(Golgi vesicle transport)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR027417|mint:P40616|rcsb pdb:1UPT|rcsb pdb:4DCN|rcsb pdb:5EE5|rcsb pdb:5J5C|reactome:R-HSA-6811440|interpro:IPR005225(Small GTP-binding protein) refseq:XP_011530171.1|refseq:NP_001020764.1|refseq:NP_001020766.1|refseq:NP_055262.1|refseq:XP_011530172.1|refseq:NP_001274360.1|refseq:NP_001274361.1|refseq:NP_001274362.1|ensembl:ENSG00000164144(gene)|ensembl:ENST00000353617(transcript)|ensembl:ENST00000451320(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0034315"(regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:1905280"(negative regulation of retrograde transport, endosome to Golgi)|interpro:IPR010504(Arfaptin-like)|interpro:IPR027267|interpro:IPR030793|interpro:IPR030798|mint:P53367 - - - figure legend:3B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/04/07 2020/04/22 rogid:4sRUSYrH1mt5ol85HlMNSEn1j9M9606 rogid:KEZ1eqEIdGfgFYIlc3WlNvqg9/89606 rigid:Tt4SjM94zrGe7akMatgIU/hplXo false myc tag:n-n glutathione s tranferase tag:n-n|mutation disrupting interaction rate:132-132|mutation with no effect:132-132 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P61204 uniprotkb:P53367 intact:EBI-641535|uniprotkb:P16587|uniprotkb:A8K6G8|ensembl:ENSP00000256682|ensembl:ENSP00000438510|uniprotkb:B7ZB63 intact:EBI-2808808|uniprotkb:Q9Y2X6|uniprotkb:Q3SYL4|uniprotkb:B4DS69|uniprotkb:Q2M2X4|ensembl:ENSP00000296557|ensembl:ENSP00000395083 psi-mi:arf3_human(display_long)|uniprotkb:ARF3(gene name)|psi-mi:ARF3(display_short) psi-mi:arfp1_human(display_long)|uniprotkb:ARFIP1(gene name)|psi-mi:ARFIP1(display_short)|uniprotkb:ADP-ribosylation factor-interacting protein 1(gene name synonym) psi-mi:"MI:0096"(pull down) Gehart et al. (2012) pubmed:22981988|imex:IM-27889 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-25568957|imex:IM-27889-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001650.1|ensembl:ENSG00000134287(gene)|ensembl:ENST00000256682(transcript)|ensembl:ENST00000541959(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070062"(extracellular exosome)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR027417|mint:P61204|rcsb pdb:6II6|reactome:R-HSA-1660514|reactome:R-HSA-6807878|reactome:R-HSA-6811434|refseq:XP_005268913.1 refseq:XP_011530171.1|refseq:NP_001020764.1|refseq:NP_001020766.1|refseq:NP_055262.1|refseq:XP_011530172.1|refseq:NP_001274360.1|refseq:NP_001274361.1|refseq:NP_001274362.1|ensembl:ENSG00000164144(gene)|ensembl:ENST00000353617(transcript)|ensembl:ENST00000451320(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0034315"(regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:1905280"(negative regulation of retrograde transport, endosome to Golgi)|interpro:IPR010504(Arfaptin-like)|interpro:IPR027267|interpro:IPR030793|interpro:IPR030798|mint:P53367 - - - figure legend:S2B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/04/07 2020/04/23 rogid:np09WjdbXRu9vgMbiXn9EA3ExqA9606 rogid:KEZ1eqEIdGfgFYIlc3WlNvqg9/89606 rigid:h6WOuFwwvdF/ThzHYTzFOpjhvOY false ha tag:n-n glutathione s tranferase tag:n-n|mutation disrupting interaction strength:132-132|mutation with no effect:132-132 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P53367 uniprotkb:P53367 intact:EBI-2808808|uniprotkb:Q9Y2X6|uniprotkb:Q3SYL4|uniprotkb:B4DS69|uniprotkb:Q2M2X4|ensembl:ENSP00000296557|ensembl:ENSP00000395083 intact:EBI-2808808|uniprotkb:Q9Y2X6|uniprotkb:Q3SYL4|uniprotkb:B4DS69|uniprotkb:Q2M2X4|ensembl:ENSP00000296557|ensembl:ENSP00000395083 psi-mi:arfp1_human(display_long)|uniprotkb:ARFIP1(gene name)|psi-mi:ARFIP1(display_short)|uniprotkb:ADP-ribosylation factor-interacting protein 1(gene name synonym) psi-mi:arfp1_human(display_long)|uniprotkb:ARFIP1(gene name)|psi-mi:ARFIP1(display_short)|uniprotkb:ADP-ribosylation factor-interacting protein 1(gene name synonym) psi-mi:"MI:0096"(pull down) Gehart et al. (2012) pubmed:22981988|imex:IM-27889 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-25569679|imex:IM-27889-13 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0898"(putative self) psi-mi:"MI:0898"(putative self) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011530171.1|refseq:NP_001020764.1|refseq:NP_001020766.1|refseq:NP_055262.1|refseq:XP_011530172.1|refseq:NP_001274360.1|refseq:NP_001274361.1|refseq:NP_001274362.1|ensembl:ENSG00000164144(gene)|ensembl:ENST00000353617(transcript)|ensembl:ENST00000451320(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0034315"(regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:1905280"(negative regulation of retrograde transport, endosome to Golgi)|interpro:IPR010504(Arfaptin-like)|interpro:IPR027267|interpro:IPR030793|interpro:IPR030798|mint:P53367 refseq:XP_011530171.1|refseq:NP_001020764.1|refseq:NP_001020766.1|refseq:NP_055262.1|refseq:XP_011530172.1|refseq:NP_001274360.1|refseq:NP_001274361.1|refseq:NP_001274362.1|ensembl:ENSG00000164144(gene)|ensembl:ENST00000353617(transcript)|ensembl:ENST00000451320(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0034315"(regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:1905280"(negative regulation of retrograde transport, endosome to Golgi)|interpro:IPR010504(Arfaptin-like)|interpro:IPR027267|interpro:IPR030793|interpro:IPR030798|mint:P53367 go:"GO:0051260"(protein homooligomerization) - - figure legend:S2A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/04/07 2021/04/26 rogid:KEZ1eqEIdGfgFYIlc3WlNvqg9/89606 rogid:KEZ1eqEIdGfgFYIlc3WlNvqg9/89606 rigid:gqCGucNdm7GZBJs7uyg6+D25xqc false flag tag:n-n glutathione s tranferase tag:n-n|mutation with no effect:132-132|mutation with no effect:132-132 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P84077 uniprotkb:P53367 intact:EBI-447171|uniprotkb:P10947|uniprotkb:P32889|ensembl:ENSP00000272102|ensembl:ENSP00000440005|ensembl:ENSP00000442980 intact:EBI-2808808|uniprotkb:Q9Y2X6|uniprotkb:Q3SYL4|uniprotkb:B4DS69|uniprotkb:Q2M2X4|ensembl:ENSP00000296557|ensembl:ENSP00000395083 psi-mi:arf1_human(display_long)|uniprotkb:ARF1(gene name)|psi-mi:ARF1(display_short) psi-mi:arfp1_human(display_long)|uniprotkb:ARFIP1(gene name)|psi-mi:ARFIP1(display_short)|uniprotkb:ADP-ribosylation factor-interacting protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gehart et al. (2012) pubmed:22981988|imex:IM-27889 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-25564495|imex:IM-27889-8 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001019397.1|refseq:NP_001019398.1|refseq:NP_001019399.1|refseq:NP_001649.1|dip:DIP-31597N|ensembl:ENSG00000143761(gene)|ensembl:ENST00000272102(transcript)|ensembl:ENST00000540651(transcript)|ensembl:ENST00000541182(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0002090"(regulation of receptor internalization)|go:"GO:0003723"(RNA binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005770"(late endosome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007015"(actin filament organization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019003"(GDP binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030137"(COPI-coated vesicle)|go:"GO:0031252"(cell leading edge)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034315"(regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0043005"(neuron projection)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045956"(positive regulation of calcium ion-dependent exocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0055108"(Golgi to transport vesicle transport)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070142"(synaptic vesicle budding)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097212"(lysosomal membrane organization)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902307"(positive regulation of sodium ion transmembrane transport)|go:"GO:1902824"(positive regulation of late endosome to lysosome transport)|go:"GO:0034379"(very-low-density lipoprotein particle assembly)|go:"GO:1903725"(regulation of phospholipid metabolic process)|go:"GO:1990386"(mitotic cleavage furrow ingression)|go:"GO:1990583"(phospholipase D activator activity)|interpro:IPR005225(Small GTP-binding protein)|go:"GO:1902953"(positive regulation of ER to Golgi vesicle-mediated transport)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR027417|mint:P84077|rcsb pdb:1HUR|rcsb pdb:1RE0|rcsb pdb:1U81|rcsb pdb:3O47|rcsb pdb:4HMY|rcsb pdb:6CM9|rcsb pdb:6CRI|rcsb pdb:6D83|rcsb pdb:6D84|rcsb pdb:6DFF|rcsb pdb:6FAE|rcsb pdb:7MGE|reactome:R-HSA-1660499|reactome:R-HSA-1660514|reactome:R-HSA-167590|reactome:R-HSA-199992|reactome:R-HSA-2132295|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811438|reactome:R-HSA-8950505 refseq:XP_011530171.1|refseq:NP_001020764.1|refseq:NP_001020766.1|refseq:NP_055262.1|refseq:XP_011530172.1|refseq:NP_001274360.1|refseq:NP_001274361.1|refseq:NP_001274362.1|ensembl:ENSG00000164144(gene)|ensembl:ENST00000353617(transcript)|ensembl:ENST00000451320(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0034315"(regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:1905280"(negative regulation of retrograde transport, endosome to Golgi)|interpro:IPR010504(Arfaptin-like)|interpro:IPR027267|interpro:IPR030793|interpro:IPR030798|mint:P53367 - - - figure legend:3c|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2020/04/07 2020/04/22 rogid:zray9asm6VonxpuJpv0dRBspPt89606 rogid:KEZ1eqEIdGfgFYIlc3WlNvqg9/89606 rigid:Ycq6GBEk+6/8Q/oDkhmKqT5I8aQ false mutation:71-71|ha tag:n-n mutation disrupting interaction strength:132-132|flag tag:n-n|mutation with no effect:132-132 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P40616 uniprotkb:P53367 intact:EBI-1052746|uniprotkb:P80417|uniprotkb:Q53XB1|uniprotkb:B4DWW1|ensembl:ENSP00000261636|intact:EBI-11157530 intact:EBI-2808808|uniprotkb:Q9Y2X6|uniprotkb:Q3SYL4|uniprotkb:B4DS69|uniprotkb:Q2M2X4|ensembl:ENSP00000296557|ensembl:ENSP00000395083 psi-mi:arl1_human(display_long)|uniprotkb:ARL1(gene name)|psi-mi:ARL1(display_short) psi-mi:arfp1_human(display_long)|uniprotkb:ARFIP1(gene name)|psi-mi:ARFIP1(display_short)|uniprotkb:ADP-ribosylation factor-interacting protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gehart et al. (2012) pubmed:22981988|imex:IM-27889 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-25569940|imex:IM-27889-15 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001168.1|ensembl:ENSG00000120805(gene)|ensembl:ENST00000261636(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007030"(Golgi organization)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0009404"(toxin metabolic process)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0046872"(metal ion binding)|go:"GO:0048193"(Golgi vesicle transport)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR027417|mint:P40616|rcsb pdb:1UPT|rcsb pdb:4DCN|rcsb pdb:5EE5|rcsb pdb:5J5C|reactome:R-HSA-6811440|interpro:IPR005225(Small GTP-binding protein) refseq:XP_011530171.1|refseq:NP_001020764.1|refseq:NP_001020766.1|refseq:NP_055262.1|refseq:XP_011530172.1|refseq:NP_001274360.1|refseq:NP_001274361.1|refseq:NP_001274362.1|ensembl:ENSG00000164144(gene)|ensembl:ENST00000353617(transcript)|ensembl:ENST00000451320(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0034315"(regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:1905280"(negative regulation of retrograde transport, endosome to Golgi)|interpro:IPR010504(Arfaptin-like)|interpro:IPR027267|interpro:IPR030793|interpro:IPR030798|mint:P53367 - - - figure legend:3d|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2020/04/07 2020/04/23 rogid:4sRUSYrH1mt5ol85HlMNSEn1j9M9606 rogid:KEZ1eqEIdGfgFYIlc3WlNvqg9/89606 rigid:Tt4SjM94zrGe7akMatgIU/hplXo false - flag tag:n-n|mutation disrupting interaction strength:132-132|mutation with no effect:132-132 - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)