#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9BRZ2	uniprotkb:Q8IUC6	intact:EBI-1048636|uniprotkb:Q6PJS5|uniprotkb:Q86VT6|uniprotkb:Q8N2H8|uniprotkb:Q8NAC0|uniprotkb:Q9H031|intact:EBI-2129929|ensembl:ENSP00000305161	intact:EBI-525995|uniprotkb:O75532|uniprotkb:Q86XP8|uniprotkb:Q96GA0|uniprotkb:B3Y691|ensembl:ENSP00000248244	psi-mi:tri56_human(display_long)|uniprotkb:RING-type E3 ubiquitin transferase TRIM56(gene name synonym)|uniprotkb:RING finger protein 109(gene name synonym)|uniprotkb:TRIM56(gene name)|psi-mi:TRIM56(display_short)|uniprotkb:RNF109(gene name synonym)|uniprotkb:Tripartite motif-containing protein 56(gene name synonym)	psi-mi:tcam1_human(display_long)|uniprotkb:PRVTIRB(gene name synonym)|uniprotkb:TRIF(gene name synonym)|uniprotkb:Proline-rich, vinculin and TIR domain-containing protein B(gene name synonym)|uniprotkb:Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta(gene name synonym)|uniprotkb:Putative NF-kappa-B-activating protein 502H(gene name synonym)|uniprotkb:TICAM1(gene name)|psi-mi:TICAM1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2012)	imex:IM-28347|pubmed:22948160	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25829457|imex:IM-28347-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_112223.1|refseq:XP_011514891.1|ensembl:ENSG00000169871(gene)|ensembl:ENST00000306085(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0032479"(regulation of type I interferon production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0034340"(response to type I interferon)|go:"GO:0045087"(innate immune response)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051607"(defense response to virus)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR027370|rcsb pdb:5JW7|reactome:R-HSA-3134975	refseq:NP_891549.1|ensembl:ENSG00000127666(gene)|ensembl:ENST00000248244(transcript)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002735"(positive regulation of myeloid dendritic cell cytokine production)|go:"GO:0005739"(mitochondrion)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006954"(inflammatory response)|go:"GO:0010008"(endosome membrane)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032816"(positive regulation of natural killer cell activation)|go:"GO:0035666"(TRIF-dependent toll-like receptor signaling pathway)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0045087"(innate immune response)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097342"(ripoptosome)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR017278(Toll-interleukin I receptor domain-containing adaptor protein, Ticam)|interpro:IPR025735|interpro:IPR035897|interpro:IPR040886|rcsb pdb:2M1X|rcsb pdb:2M63|rcsb pdb:3RC4|rcsb pdb:4BSX|rcsb pdb:4C0M|rcsb pdb:5JEL|reactome:R-HSA-140534|reactome:R-HSA-166166|reactome:R-HSA-168164|reactome:R-HSA-168927|reactome:R-HSA-1810476|reactome:R-HSA-2562578|reactome:R-HSA-5602566|reactome:R-HSA-5602571|reactome:R-HSA-9013957|reactome:R-HSA-9013973|reactome:R-HSA-9014325|reactome:R-HSA-936964|reactome:R-HSA-937041|reactome:R-HSA-937072|reactome:R-HSA-975163|dip:DIP-33490N	-	-	-	figure legend:8B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2020/09/14	2020/09/15	rogid:ezli6d8R3mc5aNovKvPv2ayypbE9606	rogid:QolsJvUL2R6GSyE8ZmpFyJIBoH89606	rigid:pjpGe3xrYhIB1Wo/+BXj84MMr2w	false	ha tag:n-n	flag tag:c-c|mutation:687-690	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9BRZ2	uniprotkb:Q8IUC6	intact:EBI-1048636|uniprotkb:Q6PJS5|uniprotkb:Q86VT6|uniprotkb:Q8N2H8|uniprotkb:Q8NAC0|uniprotkb:Q9H031|intact:EBI-2129929|ensembl:ENSP00000305161	intact:EBI-525995|uniprotkb:O75532|uniprotkb:Q86XP8|uniprotkb:Q96GA0|uniprotkb:B3Y691|ensembl:ENSP00000248244	psi-mi:tri56_human(display_long)|uniprotkb:RING-type E3 ubiquitin transferase TRIM56(gene name synonym)|uniprotkb:RING finger protein 109(gene name synonym)|uniprotkb:TRIM56(gene name)|psi-mi:TRIM56(display_short)|uniprotkb:RNF109(gene name synonym)|uniprotkb:Tripartite motif-containing protein 56(gene name synonym)	psi-mi:tcam1_human(display_long)|uniprotkb:PRVTIRB(gene name synonym)|uniprotkb:TRIF(gene name synonym)|uniprotkb:Proline-rich, vinculin and TIR domain-containing protein B(gene name synonym)|uniprotkb:Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta(gene name synonym)|uniprotkb:Putative NF-kappa-B-activating protein 502H(gene name synonym)|uniprotkb:TICAM1(gene name)|psi-mi:TICAM1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2012)	imex:IM-28347|pubmed:22948160	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25829507|imex:IM-28347-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_112223.1|refseq:XP_011514891.1|ensembl:ENSG00000169871(gene)|ensembl:ENST00000306085(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0032479"(regulation of type I interferon production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0034340"(response to type I interferon)|go:"GO:0045087"(innate immune response)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051607"(defense response to virus)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR027370|rcsb pdb:5JW7|reactome:R-HSA-3134975	refseq:NP_891549.1|ensembl:ENSG00000127666(gene)|ensembl:ENST00000248244(transcript)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002735"(positive regulation of myeloid dendritic cell cytokine production)|go:"GO:0005739"(mitochondrion)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006954"(inflammatory response)|go:"GO:0010008"(endosome membrane)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032816"(positive regulation of natural killer cell activation)|go:"GO:0035666"(TRIF-dependent toll-like receptor signaling pathway)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0045087"(innate immune response)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097342"(ripoptosome)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR017278(Toll-interleukin I receptor domain-containing adaptor protein, Ticam)|interpro:IPR025735|interpro:IPR035897|interpro:IPR040886|rcsb pdb:2M1X|rcsb pdb:2M63|rcsb pdb:3RC4|rcsb pdb:4BSX|rcsb pdb:4C0M|rcsb pdb:5JEL|reactome:R-HSA-140534|reactome:R-HSA-166166|reactome:R-HSA-168164|reactome:R-HSA-168927|reactome:R-HSA-1810476|reactome:R-HSA-2562578|reactome:R-HSA-5602566|reactome:R-HSA-5602571|reactome:R-HSA-9013957|reactome:R-HSA-9013973|reactome:R-HSA-9014325|reactome:R-HSA-936964|reactome:R-HSA-937041|reactome:R-HSA-937072|reactome:R-HSA-975163|dip:DIP-33490N	-	-	-	figure legend:8C, Supp. figure 4|comment:"A RING domain-deleted TRIM56 (mutant A, probable amino acid  range 21..21-60..60) still associated with TRIF."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2020/09/14	2020/09/15	rogid:ezli6d8R3mc5aNovKvPv2ayypbE9606	rogid:QolsJvUL2R6GSyE8ZmpFyJIBoH89606	rigid:pjpGe3xrYhIB1Wo/+BXj84MMr2w	false	necessary binding region:621-695|ha tag:n-n|necessary binding region:693-750	flag tag:c-c|mutation:687-690	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)