#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9UGM3	uniprotkb:P11226	intact:EBI-1044970|uniprotkb:Q59EX0|uniprotkb:Q5JR26|uniprotkb:Q6MZN4|uniprotkb:Q96DU4|uniprotkb:Q9UGM2|uniprotkb:Q9UJ57|uniprotkb:Q9UKJ4|uniprotkb:Q9Y211|uniprotkb:Q9Y4V9|uniprotkb:A6NDG4|uniprotkb:A6NDJ5|uniprotkb:A8E4R5|uniprotkb:B1ARE7|uniprotkb:B1ARE8|uniprotkb:B1ARE9|uniprotkb:B1ARF0|uniprotkb:B7Z8Y2|uniprotkb:F8WEF7|ensembl:ENSP00000357905|ensembl:ENSP00000484603|ensembl:ENSP00000498825	intact:EBI-5325353|ensembl:ENSP00000363079|ensembl:ENSP00000502615|ensembl:ENSP00000502789|uniprotkb:Q4VB12|uniprotkb:Q4VB13|uniprotkb:Q86SI4|uniprotkb:Q96KE4|uniprotkb:Q96TF7|uniprotkb:Q96TF8|uniprotkb:Q96TF9|uniprotkb:Q4VB14|uniprotkb:Q5SQS3	psi-mi:dmbt1_human(display_long)|uniprotkb:Glycoprotein 340(gene name synonym)|uniprotkb:Surfactant pulmonary-associated D-binding protein(gene name synonym)|uniprotkb:Hensin(gene name synonym)|uniprotkb:DMBT1(gene name)|psi-mi:DMBT1(display_short)|uniprotkb:GP340(gene name synonym)|uniprotkb:Salivary agglutinin(gene name synonym)	psi-mi:mbl2_human(display_long)|uniprotkb:MBL2(gene name)|psi-mi:MBL2(display_short)|uniprotkb:COLEC1(gene name synonym)|uniprotkb:MBL(gene name synonym)|uniprotkb:Collectin-1(gene name synonym)|uniprotkb:MBP1(gene name synonym)|uniprotkb:Mannan-binding protein(gene name synonym)|uniprotkb:Mannose-binding lectin(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Reichhardt et al. (2011)	pubmed:22811680|imex:IM-28603	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26581826|imex:IM-28603-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004397.2|refseq:NP_015568.2|refseq:NP_060049.2|refseq:XP_011537690.1|refseq:XP_011537693.1|refseq:XP_011537707.1|refseq:NP_001307573.1|dip:DIP-50763N|ensembl:ENSG00000187908(gene)|ensembl:ENST00000368909(transcript)|ensembl:ENST00000619379(transcript)|ensembl:ENST00000652446(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006952"(defense response)|go:"GO:0015031"(protein transport)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035375"(zymogen binding)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042494"(detection of bacterial lipoprotein)|go:"GO:0042589"(zymogen granule membrane)|go:"GO:0043152"(induction of bacterial agglutination)|go:"GO:0045087"(innate immune response)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070891"(lipoteichoic acid binding)|go:"GO:1904399"(heparan sulfate binding)|interpro:IPR000859(CUB)|interpro:IPR001190(Speract/scavenger receptor)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017448(Speract/scavenger receptor related)|interpro:IPR017977|interpro:IPR035914|interpro:IPR036772|interpro:IPR042235|mint:Q9UGM3|rcsb pdb:6SA4|rcsb pdb:6SA5|rcsb pdb:6SAN|reactome:R-HSA-5683826	ensembl:ENSG00000165471(gene)|ensembl:ENST00000373968(transcript)|ensembl:ENST00000674931(transcript)|ensembl:ENST00000675947(transcript)|go:"GO:0001867"(complement activation, lectin pathway)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005537"(mannose binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0006953"(acute-phase response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008228"(opsonization)|go:"GO:0009986"(cell surface)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048525"(negative regulation of viral process)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR001304(C-type lectin)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR016186(C-type lectin-like)|refseq:XP_011538118.1|interpro:IPR018378|interpro:IPR033990|interpro:IPR037570|rcsb pdb:1HUP|interpro:IPR016187(C-type lectin fold)|reactome:R-HSA-166662|reactome:R-HSA-166663|refseq:NP_000233.1|refseq:XP_006717924.1|dip:DIP-61381N	-	-	-	figure legend:2, number 1|agonist:Ca2+|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/18	2020/12/31	rogid:A0Aw2F/rHW8mFmPDg4xOTy8NGzg9606	rogid:uo0RM88uw3otObIVnOhUcOfW8yo9606	rigid:S8qzQKuHOki2BagQfeQDa7cRf4c	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:O75636	uniprotkb:Q9UGM3	intact:EBI-11786958|uniprotkb:Q6IBJ5|uniprotkb:Q8WW86|ensembl:ENSP00000270879	intact:EBI-1044970|uniprotkb:Q59EX0|uniprotkb:Q5JR26|uniprotkb:Q6MZN4|uniprotkb:Q96DU4|uniprotkb:Q9UGM2|uniprotkb:Q9UJ57|uniprotkb:Q9UKJ4|uniprotkb:Q9Y211|uniprotkb:Q9Y4V9|uniprotkb:A6NDG4|uniprotkb:A6NDJ5|uniprotkb:A8E4R5|uniprotkb:B1ARE7|uniprotkb:B1ARE8|uniprotkb:B1ARE9|uniprotkb:B1ARF0|uniprotkb:B7Z8Y2|uniprotkb:F8WEF7|ensembl:ENSP00000357905|ensembl:ENSP00000484603|ensembl:ENSP00000498825	psi-mi:fcn3_human(display_long)|uniprotkb:FCN3(gene name)|psi-mi:FCN3(display_short)|uniprotkb:FCNH(gene name synonym)|uniprotkb:HAKA1(gene name synonym)|uniprotkb:Collagen/fibrinogen domain-containing lectin 3 p35(gene name synonym)|uniprotkb:Collagen/fibrinogen domain-containing protein 3(gene name synonym)|uniprotkb:Hakata antigen(gene name synonym)	psi-mi:dmbt1_human(display_long)|uniprotkb:Glycoprotein 340(gene name synonym)|uniprotkb:Surfactant pulmonary-associated D-binding protein(gene name synonym)|uniprotkb:Hensin(gene name synonym)|uniprotkb:DMBT1(gene name)|psi-mi:DMBT1(display_short)|uniprotkb:GP340(gene name synonym)|uniprotkb:Salivary agglutinin(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Reichhardt et al. (2011)	pubmed:22811680|imex:IM-28603	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26581831|imex:IM-28603-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003656.2|refseq:NP_775628.1|ensembl:ENSG00000142748(gene)|ensembl:ENST00000270879(transcript)|go:"GO:0001867"(complement activation, lectin pathway)|go:"GO:0003823"(antigen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0006956"(complement activation)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0043654"(recognition of apoptotic cell)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0072562"(blood microparticle)|go:"GO:1902679"(negative regulation of RNA biosynthetic process)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|interpro:IPR036056|rcsb pdb:1LA5|rcsb pdb:2J5Z|rcsb pdb:2J60|rcsb pdb:2J64|reactome:R-HSA-166662|reactome:R-HSA-166663|reactome:R-HSA-2855086	refseq:NP_004397.2|refseq:NP_015568.2|refseq:NP_060049.2|refseq:XP_011537690.1|refseq:XP_011537693.1|refseq:XP_011537707.1|refseq:NP_001307573.1|dip:DIP-50763N|ensembl:ENSG00000187908(gene)|ensembl:ENST00000368909(transcript)|ensembl:ENST00000619379(transcript)|ensembl:ENST00000652446(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006952"(defense response)|go:"GO:0015031"(protein transport)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035375"(zymogen binding)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042494"(detection of bacterial lipoprotein)|go:"GO:0042589"(zymogen granule membrane)|go:"GO:0043152"(induction of bacterial agglutination)|go:"GO:0045087"(innate immune response)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070891"(lipoteichoic acid binding)|go:"GO:1904399"(heparan sulfate binding)|interpro:IPR000859(CUB)|interpro:IPR001190(Speract/scavenger receptor)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017448(Speract/scavenger receptor related)|interpro:IPR017977|interpro:IPR035914|interpro:IPR036772|interpro:IPR042235|mint:Q9UGM3|rcsb pdb:6SA4|rcsb pdb:6SA5|rcsb pdb:6SAN|reactome:R-HSA-5683826	-	-	-	figure legend:2, number 2|agonist:Ca2+|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/18	2021/01/01	rogid:Uqrs95TKW2LaGqmcRkU9cu3v2FA9606	rogid:A0Aw2F/rHW8mFmPDg4xOTy8NGzg9606	rigid:kONJHOx/fK/LoIcwbgtjt1KdKN8	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q15485	uniprotkb:Q9UGM3	intact:EBI-7468784|uniprotkb:A6NFG7|uniprotkb:Q9UC57|uniprotkb:Q6IS69|intact:MINT-5223224|uniprotkb:Q7M4P4|uniprotkb:A8K478|ensembl:ENSP00000291744	intact:EBI-1044970|uniprotkb:Q59EX0|uniprotkb:Q5JR26|uniprotkb:Q6MZN4|uniprotkb:Q96DU4|uniprotkb:Q9UGM2|uniprotkb:Q9UJ57|uniprotkb:Q9UKJ4|uniprotkb:Q9Y211|uniprotkb:Q9Y4V9|uniprotkb:A6NDG4|uniprotkb:A6NDJ5|uniprotkb:A8E4R5|uniprotkb:B1ARE7|uniprotkb:B1ARE8|uniprotkb:B1ARE9|uniprotkb:B1ARF0|uniprotkb:B7Z8Y2|uniprotkb:F8WEF7|ensembl:ENSP00000357905|ensembl:ENSP00000484603|ensembl:ENSP00000498825	psi-mi:fcn2_human(display_long)|uniprotkb:FCN2(gene name)|psi-mi:FCN2(display_short)|uniprotkb:FCNL(gene name synonym)|uniprotkb:Ficolin-B(gene name synonym)|uniprotkb:Ficolin-beta(gene name synonym)|uniprotkb:L-ficolin(gene name synonym)|uniprotkb:Collagen/fibrinogen domain-containing protein 2(gene name synonym)|uniprotkb:Serum lectin p35(gene name synonym)|uniprotkb:37 kDa elastin-binding protein(gene name synonym)|uniprotkb:EBP-37(gene name synonym)|uniprotkb:Hucolin(gene name synonym)	psi-mi:dmbt1_human(display_long)|uniprotkb:Glycoprotein 340(gene name synonym)|uniprotkb:Surfactant pulmonary-associated D-binding protein(gene name synonym)|uniprotkb:Hensin(gene name synonym)|uniprotkb:DMBT1(gene name)|psi-mi:DMBT1(display_short)|uniprotkb:GP340(gene name synonym)|uniprotkb:Salivary agglutinin(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Reichhardt et al. (2011)	pubmed:22811680|imex:IM-28603	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26581836|imex:IM-28603-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004099.2|refseq:NP_056652.1|ensembl:ENSG00000160339(gene)|ensembl:ENST00000291744(transcript)|go:"GO:0001867"(complement activation, lectin pathway)|go:"GO:0003823"(antigen binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0008228"(opsonization)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0043654"(recognition of apoptotic cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0097367"(carbohydrate derivative binding)|go:"GO:2001065"(mannan binding)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|interpro:IPR036056|mint:Q15485|rcsb pdb:2J0G|rcsb pdb:2J0H|rcsb pdb:2J0Y|rcsb pdb:2J1G|rcsb pdb:2J2P|rcsb pdb:2J3F|rcsb pdb:2J3G|rcsb pdb:2J3O|rcsb pdb:2J3U|rcsb pdb:2J61|rcsb pdb:4NYT|rcsb pdb:4R9J|rcsb pdb:4R9T|reactome:R-HSA-166662|reactome:R-HSA-166663|reactome:R-HSA-2855086	refseq:NP_004397.2|refseq:NP_015568.2|refseq:NP_060049.2|refseq:XP_011537690.1|refseq:XP_011537693.1|refseq:XP_011537707.1|refseq:NP_001307573.1|dip:DIP-50763N|ensembl:ENSG00000187908(gene)|ensembl:ENST00000368909(transcript)|ensembl:ENST00000619379(transcript)|ensembl:ENST00000652446(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006952"(defense response)|go:"GO:0015031"(protein transport)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035375"(zymogen binding)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042494"(detection of bacterial lipoprotein)|go:"GO:0042589"(zymogen granule membrane)|go:"GO:0043152"(induction of bacterial agglutination)|go:"GO:0045087"(innate immune response)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070891"(lipoteichoic acid binding)|go:"GO:1904399"(heparan sulfate binding)|interpro:IPR000859(CUB)|interpro:IPR001190(Speract/scavenger receptor)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017448(Speract/scavenger receptor related)|interpro:IPR017977|interpro:IPR035914|interpro:IPR036772|interpro:IPR042235|mint:Q9UGM3|rcsb pdb:6SA4|rcsb pdb:6SA5|rcsb pdb:6SAN|reactome:R-HSA-5683826	-	comment:mint|function:Calcium-dependent and GlcNAc-binding lectin. Enhanced phagocytosis of S.typhimurium by neutrophils, suggesting an opsonic effect via the collagen region	-	figure legend:2, number 3|agonist:Ca2+|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/18	2021/01/01	rogid:j6vRtYG3I6cn0c2TId/73bE/1To9606	rogid:A0Aw2F/rHW8mFmPDg4xOTy8NGzg9606	rigid:HA4KfZxTbusgON1Ykyj48cR4uIU	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P0C0L4	uniprotkb:P0C0L5	intact:EBI-1223619|uniprotkb:P01028|uniprotkb:P78445|uniprotkb:Q13160|uniprotkb:Q13906|uniprotkb:Q14033|uniprotkb:Q14835|uniprotkb:Q5JQM8|uniprotkb:Q9NPK5|uniprotkb:Q9UIP5|uniprotkb:B0QZR6|uniprotkb:A6H8M8|uniprotkb:A6NHJ5|uniprotkb:A7E2V2|uniprotkb:B0V2C8|uniprotkb:B2RUT6|uniprotkb:B7ZVZ6|uniprotkb:Q4LE82|uniprotkb:Q5JNX2|uniprotkb:Q6P4R1|uniprotkb:Q6U2E5|uniprotkb:Q6U2E8|uniprotkb:Q6U2F0|uniprotkb:Q6U2F3|uniprotkb:Q6U2F4|uniprotkb:Q6U2F6|uniprotkb:Q6U2F8|uniprotkb:Q6U2G0|uniprotkb:Q96EG2|uniprotkb:Q96SA8|ensembl:ENSP00000388662|ensembl:ENSP00000396688|ensembl:ENSP00000372815	intact:EBI-2872887|ensembl:ENSP00000364321|ensembl:ENSP00000407942|ensembl:ENSP00000412786|ensembl:ENSP00000414200|ensembl:ENSP00000415941|uniprotkb:Q9NPK5|uniprotkb:Q9UIP5|uniprotkb:Q14033|uniprotkb:P01028|uniprotkb:Q13906|uniprotkb:Q13160|uniprotkb:Q14835|uniprotkb:P78445|uniprotkb:A2BHY4|uniprotkb:Q6U2E9|uniprotkb:Q6U2G1|uniprotkb:Q6U2I5|uniprotkb:Q6U2L1|uniprotkb:Q6U2L7|uniprotkb:Q6U2L9|uniprotkb:Q6U2M5|uniprotkb:Q6VCV8|uniprotkb:Q96SA7	psi-mi:co4a_human(display_long)|uniprotkb:C4A(gene name)|psi-mi:C4A(display_short)|uniprotkb:CO4(gene name synonym)|uniprotkb:CPAMD2(gene name synonym)|uniprotkb:Acidic complement C4(gene name synonym)|uniprotkb:C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2(gene name synonym)	psi-mi:co4b_human(display_long)|uniprotkb:C4B(gene name)|psi-mi:C4B(display_short)|uniprotkb:C4B_2(gene name)|psi-mi:C4B_2(display_short)|uniprotkb:Basic complement C4(gene name synonym)|uniprotkb:C3 and PZP-like alpha-2-macroglobulin domain-containing protein 3(gene name synonym)|uniprotkb:CO4(gene name synonym)|uniprotkb:CPAMD3(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Reichhardt et al. (2011)	pubmed:22811680|imex:IM-28603	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26581841|imex:IM-28603-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009224.2|refseq:NP_001002029.3|refseq:NP_001239133.1|ensembl:ENSG00000206340(gene)|ensembl:ENSG00000227746(gene)|ensembl:ENSG00000244731(gene)|ensembl:ENST00000383325(transcript)|ensembl:ENST00000421274(transcript)|ensembl:ENST00000428956(transcript)|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006956"(complement activation)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0045202"(synapse)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:2000427"(positive regulation of apoptotic cell clearance)|interpro:IPR000020(Anaphylatoxin/fibulin)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR001599(Alpha-2-macroglobulin)|interpro:IPR001840(Complement C3a/C4a/C5a anaphylatoxin)|interpro:IPR002890(Alpha-2-macroglobulin, N-terminal)|interpro:IPR008930(Terpenoid cylases/protein prenyltransferase alpha-alpha toroid)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR009048(Alpha-macroglobulin, receptor-binding)|interpro:IPR011625(Alpha-2-macroglobulin, N-terminal 2)|interpro:IPR011626(A-macroglobulin complement component)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR018081|interpro:IPR018933|interpro:IPR019742|interpro:IPR036595|interpro:IPR037569|interpro:IPR040839|interpro:IPR041555|rcsb pdb:1HZF|rcsb pdb:4FXG|rcsb pdb:4FXK|rcsb pdb:4XAM|rcsb pdb:5JPM|rcsb pdb:5JPN|rcsb pdb:5JTW|reactome:R-HSA-166663|reactome:R-HSA-174577|reactome:R-HSA-381426|reactome:R-HSA-8957275|reactome:R-HSA-977606	ensembl:ENSG00000224389(gene)|ensembl:ENSG00000228267(gene)|ensembl:ENSG00000228454(gene)|ensembl:ENSG00000233312(gene)|ensembl:ENSG00000236625(gene)|ensembl:ENST00000375177(transcript)|go:"GO:0006954"(inflammatory response)|go:"GO:0006956"(complement activation)|go:"GO:0006958"(complement activation, classical pathway)|ensembl:ENST00000411583(transcript)|go:"GO:0008228"(opsonization)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030424"(axon)|ensembl:ENST00000435363(transcript)|go:"GO:0030425"(dendrite)|ensembl:ENST00000435500(transcript)|go:"GO:0032490"(detection of molecule of bacterial origin)|go:"GO:0045087"(innate immune response)|go:"GO:0045202"(synapse)|ensembl:ENST00000449788(transcript)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0001848"(complement binding)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0106139"(symbiont cell surface)|go:"GO:0005576"(extracellular region)|go:"GO:2000427"(positive regulation of apoptotic cell clearance)|interpro:IPR000020(Anaphylatoxin/fibulin)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR001599(Alpha-2-macroglobulin)|interpro:IPR001840(Complement C3a/C4a/C5a anaphylatoxin)|interpro:IPR002890(Alpha-2-macroglobulin, N-terminal)|go:"GO:0005615"(extracellular space)|interpro:IPR008930(Terpenoid cylases/protein prenyltransferase alpha-alpha toroid)|go:"GO:0005886"(plasma membrane)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR009048(Alpha-macroglobulin, receptor-binding)|interpro:IPR011625(Alpha-2-macroglobulin, N-terminal 2)|interpro:IPR011626(A-macroglobulin complement component)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR018081|interpro:IPR018933|rcsb pdb:4XAM|rcsb pdb:6YSQ|reactome:R-HSA-166663|reactome:R-HSA-174577|reactome:R-HSA-977606|interpro:IPR019742|interpro:IPR036595|interpro:IPR037569|interpro:IPR040839|interpro:IPR041555|mint:P0C0L5|refseq:NP_001002029.3|refseq:NP_001229752.1|dip:DIP-47260N	-	-	-	figure legend:2, number 6|agonist:Ca2+|comment:"C4 (a mixture of C4A and C4B) circulates in blood as a disulfide-linked trimer of alpha, beta and gamma chains."|comment:weak binding|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/18	2021/01/01	rogid:nLlIFlW5RCngnXASkYPGREjA/1E9606	rogid:Q4ytozbL9pAYkvi+FftBnQ2fJvw9606	rigid:H5FeAMvCJce1Dfx3CI4CKmqJl5s	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P0C0L4	uniprotkb:Q9UGM3	intact:EBI-1223619|uniprotkb:P01028|uniprotkb:P78445|uniprotkb:Q13160|uniprotkb:Q13906|uniprotkb:Q14033|uniprotkb:Q14835|uniprotkb:Q5JQM8|uniprotkb:Q9NPK5|uniprotkb:Q9UIP5|uniprotkb:B0QZR6|uniprotkb:A6H8M8|uniprotkb:A6NHJ5|uniprotkb:A7E2V2|uniprotkb:B0V2C8|uniprotkb:B2RUT6|uniprotkb:B7ZVZ6|uniprotkb:Q4LE82|uniprotkb:Q5JNX2|uniprotkb:Q6P4R1|uniprotkb:Q6U2E5|uniprotkb:Q6U2E8|uniprotkb:Q6U2F0|uniprotkb:Q6U2F3|uniprotkb:Q6U2F4|uniprotkb:Q6U2F6|uniprotkb:Q6U2F8|uniprotkb:Q6U2G0|uniprotkb:Q96EG2|uniprotkb:Q96SA8|ensembl:ENSP00000388662|ensembl:ENSP00000396688|ensembl:ENSP00000372815	intact:EBI-1044970|uniprotkb:Q59EX0|uniprotkb:Q5JR26|uniprotkb:Q6MZN4|uniprotkb:Q96DU4|uniprotkb:Q9UGM2|uniprotkb:Q9UJ57|uniprotkb:Q9UKJ4|uniprotkb:Q9Y211|uniprotkb:Q9Y4V9|uniprotkb:A6NDG4|uniprotkb:A6NDJ5|uniprotkb:A8E4R5|uniprotkb:B1ARE7|uniprotkb:B1ARE8|uniprotkb:B1ARE9|uniprotkb:B1ARF0|uniprotkb:B7Z8Y2|uniprotkb:F8WEF7|ensembl:ENSP00000357905|ensembl:ENSP00000484603|ensembl:ENSP00000498825	psi-mi:co4a_human(display_long)|uniprotkb:C4A(gene name)|psi-mi:C4A(display_short)|uniprotkb:CO4(gene name synonym)|uniprotkb:CPAMD2(gene name synonym)|uniprotkb:Acidic complement C4(gene name synonym)|uniprotkb:C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2(gene name synonym)	psi-mi:dmbt1_human(display_long)|uniprotkb:Glycoprotein 340(gene name synonym)|uniprotkb:Surfactant pulmonary-associated D-binding protein(gene name synonym)|uniprotkb:Hensin(gene name synonym)|uniprotkb:DMBT1(gene name)|psi-mi:DMBT1(display_short)|uniprotkb:GP340(gene name synonym)|uniprotkb:Salivary agglutinin(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Reichhardt et al. (2011)	pubmed:22811680|imex:IM-28603	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26581841|imex:IM-28603-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009224.2|refseq:NP_001002029.3|refseq:NP_001239133.1|ensembl:ENSG00000206340(gene)|ensembl:ENSG00000227746(gene)|ensembl:ENSG00000244731(gene)|ensembl:ENST00000383325(transcript)|ensembl:ENST00000421274(transcript)|ensembl:ENST00000428956(transcript)|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006956"(complement activation)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0045202"(synapse)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:2000427"(positive regulation of apoptotic cell clearance)|interpro:IPR000020(Anaphylatoxin/fibulin)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR001599(Alpha-2-macroglobulin)|interpro:IPR001840(Complement C3a/C4a/C5a anaphylatoxin)|interpro:IPR002890(Alpha-2-macroglobulin, N-terminal)|interpro:IPR008930(Terpenoid cylases/protein prenyltransferase alpha-alpha toroid)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR009048(Alpha-macroglobulin, receptor-binding)|interpro:IPR011625(Alpha-2-macroglobulin, N-terminal 2)|interpro:IPR011626(A-macroglobulin complement component)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR018081|interpro:IPR018933|interpro:IPR019742|interpro:IPR036595|interpro:IPR037569|interpro:IPR040839|interpro:IPR041555|rcsb pdb:1HZF|rcsb pdb:4FXG|rcsb pdb:4FXK|rcsb pdb:4XAM|rcsb pdb:5JPM|rcsb pdb:5JPN|rcsb pdb:5JTW|reactome:R-HSA-166663|reactome:R-HSA-174577|reactome:R-HSA-381426|reactome:R-HSA-8957275|reactome:R-HSA-977606	refseq:NP_004397.2|refseq:NP_015568.2|refseq:NP_060049.2|refseq:XP_011537690.1|refseq:XP_011537693.1|refseq:XP_011537707.1|refseq:NP_001307573.1|dip:DIP-50763N|ensembl:ENSG00000187908(gene)|ensembl:ENST00000368909(transcript)|ensembl:ENST00000619379(transcript)|ensembl:ENST00000652446(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006952"(defense response)|go:"GO:0015031"(protein transport)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035375"(zymogen binding)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042494"(detection of bacterial lipoprotein)|go:"GO:0042589"(zymogen granule membrane)|go:"GO:0043152"(induction of bacterial agglutination)|go:"GO:0045087"(innate immune response)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070891"(lipoteichoic acid binding)|go:"GO:1904399"(heparan sulfate binding)|interpro:IPR000859(CUB)|interpro:IPR001190(Speract/scavenger receptor)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017448(Speract/scavenger receptor related)|interpro:IPR017977|interpro:IPR035914|interpro:IPR036772|interpro:IPR042235|mint:Q9UGM3|rcsb pdb:6SA4|rcsb pdb:6SA5|rcsb pdb:6SAN|reactome:R-HSA-5683826	-	-	-	figure legend:2, number 6|agonist:Ca2+|comment:"C4 (a mixture of C4A and C4B) circulates in blood as a disulfide-linked trimer of alpha, beta and gamma chains."|comment:weak binding|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/18	2021/01/01	rogid:nLlIFlW5RCngnXASkYPGREjA/1E9606	rogid:A0Aw2F/rHW8mFmPDg4xOTy8NGzg9606	rigid:H5FeAMvCJce1Dfx3CI4CKmqJl5s	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:O00602	uniprotkb:Q9UGM3	intact:EBI-5282479|uniprotkb:Q5VYV5|uniprotkb:Q92596|ensembl:ENSP00000360871	intact:EBI-1044970|uniprotkb:Q59EX0|uniprotkb:Q5JR26|uniprotkb:Q6MZN4|uniprotkb:Q96DU4|uniprotkb:Q9UGM2|uniprotkb:Q9UJ57|uniprotkb:Q9UKJ4|uniprotkb:Q9Y211|uniprotkb:Q9Y4V9|uniprotkb:A6NDG4|uniprotkb:A6NDJ5|uniprotkb:A8E4R5|uniprotkb:B1ARE7|uniprotkb:B1ARE8|uniprotkb:B1ARE9|uniprotkb:B1ARF0|uniprotkb:B7Z8Y2|uniprotkb:F8WEF7|ensembl:ENSP00000357905|ensembl:ENSP00000484603|ensembl:ENSP00000498825	psi-mi:fcn1_human(display_long)|uniprotkb:FCN1(gene name)|psi-mi:FCN1(display_short)|uniprotkb:FCNM(gene name synonym)|uniprotkb:Collagen/fibrinogen domain-containing protein 1(gene name synonym)|uniprotkb:Ficolin-A(gene name synonym)|uniprotkb:Ficolin-alpha(gene name synonym)|uniprotkb:M-ficolin(gene name synonym)	psi-mi:dmbt1_human(display_long)|uniprotkb:Glycoprotein 340(gene name synonym)|uniprotkb:Surfactant pulmonary-associated D-binding protein(gene name synonym)|uniprotkb:Hensin(gene name synonym)|uniprotkb:DMBT1(gene name)|psi-mi:DMBT1(display_short)|uniprotkb:GP340(gene name synonym)|uniprotkb:Salivary agglutinin(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Reichhardt et al. (2011)	pubmed:22811680|imex:IM-28603	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26581846|imex:IM-28603-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001994.2|ensembl:ENSG00000085265(gene)|ensembl:ENST00000371806(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001867"(complement activation, lectin pathway)|go:"GO:0002752"(cell surface pattern recognition receptor signaling pathway)|go:"GO:0003823"(antigen binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0031232"(extrinsic component of external side of plasma membrane)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033691"(sialic acid binding)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0043654"(recognition of apoptotic cell)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0097367"(carbohydrate derivative binding)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|interpro:IPR036056|mint:O00602|rcsb pdb:2D39|rcsb pdb:2JHH|rcsb pdb:2JHI|rcsb pdb:2JHK|rcsb pdb:2JHL|rcsb pdb:2JHM|rcsb pdb:2WNP|reactome:R-HSA-166662|reactome:R-HSA-166663|reactome:R-HSA-2855086|reactome:R-HSA-6798695	refseq:NP_004397.2|refseq:NP_015568.2|refseq:NP_060049.2|refseq:XP_011537690.1|refseq:XP_011537693.1|refseq:XP_011537707.1|refseq:NP_001307573.1|dip:DIP-50763N|ensembl:ENSG00000187908(gene)|ensembl:ENST00000368909(transcript)|ensembl:ENST00000619379(transcript)|ensembl:ENST00000652446(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006952"(defense response)|go:"GO:0015031"(protein transport)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035375"(zymogen binding)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042494"(detection of bacterial lipoprotein)|go:"GO:0042589"(zymogen granule membrane)|go:"GO:0043152"(induction of bacterial agglutination)|go:"GO:0045087"(innate immune response)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070891"(lipoteichoic acid binding)|go:"GO:1904399"(heparan sulfate binding)|interpro:IPR000859(CUB)|interpro:IPR001190(Speract/scavenger receptor)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017448(Speract/scavenger receptor related)|interpro:IPR017977|interpro:IPR035914|interpro:IPR036772|interpro:IPR042235|mint:Q9UGM3|rcsb pdb:6SA4|rcsb pdb:6SA5|rcsb pdb:6SAN|reactome:R-HSA-5683826	-	-	-	figure legend:2, number 5|agonist:Ca2+|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/18	2021/01/01	rogid:7qu36ZaWgX+GyX+QUbGj0RGrp4U9606	rogid:A0Aw2F/rHW8mFmPDg4xOTy8NGzg9606	rigid:2BTWtag9HMc4OUH44gR81bmAONg	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
matrixdb:MULT_82_human	uniprotkb:Q9UGM3	intact:EBI-6264901|reactome:R-HSA-173579|wwpdb:1PK6|wwpdb:2wnv|wwpdb:2jg8|wwpdb:2jg9|wwpdb:2wnu|reactome:R-HSA-173588	intact:EBI-1044970|uniprotkb:Q59EX0|uniprotkb:Q5JR26|uniprotkb:Q6MZN4|uniprotkb:Q96DU4|uniprotkb:Q9UGM2|uniprotkb:Q9UJ57|uniprotkb:Q9UKJ4|uniprotkb:Q9Y211|uniprotkb:Q9Y4V9|uniprotkb:A6NDG4|uniprotkb:A6NDJ5|uniprotkb:A8E4R5|uniprotkb:B1ARE7|uniprotkb:B1ARE8|uniprotkb:B1ARE9|uniprotkb:B1ARF0|uniprotkb:B7Z8Y2|uniprotkb:F8WEF7|ensembl:ENSP00000357905|ensembl:ENSP00000484603|ensembl:ENSP00000498825	psi-mi:c1q_human(display_short)|psi-mi:MULT_82_human(display_long)|intact:Complement component C1q complex(complex recommended name)|intact:C1q(complex synonym)|intact:Complement 1q(complex synonym)|intact:C1QA-C1QB-C1QC complex(complex synonym)|intact:"6xC1QA:6xC1QB:6xC1QC"(complex systematic name)	psi-mi:dmbt1_human(display_long)|uniprotkb:Glycoprotein 340(gene name synonym)|uniprotkb:Surfactant pulmonary-associated D-binding protein(gene name synonym)|uniprotkb:Hensin(gene name synonym)|uniprotkb:DMBT1(gene name)|psi-mi:DMBT1(display_short)|uniprotkb:GP340(gene name synonym)|uniprotkb:Salivary agglutinin(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Reichhardt et al. (2011)	pubmed:22811680|imex:IM-28603	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26581851|imex:IM-28603-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:0326"(protein)	go:"GO:0005509"(calcium ion binding)|go:"GO:0019865"(immunoglobulin binding)|efo:"MONDO:0013343"(see-also)|pubmed:28601358(see-also)|pubmed:22536204(see-also)|intact:EBI-6264878(exp-evidence)|evidence ontology:"ECO:0000353"|complex portal:CPX-1919(complex-primary)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0005576"(extracellular region)|pubmed:20548024(see-also)|pubmed:29449492(see-also)|pubmed:18250442(see-also)|go:"GO:0062167"(complement component C1q complex)|pubmed:31165008(see-also)|pubmed:27914690(see-also)|pubmed:26489954(see-also)	refseq:NP_004397.2|refseq:NP_015568.2|refseq:NP_060049.2|refseq:XP_011537690.1|refseq:XP_011537693.1|refseq:XP_011537707.1|refseq:NP_001307573.1|dip:DIP-50763N|ensembl:ENSG00000187908(gene)|ensembl:ENST00000368909(transcript)|ensembl:ENST00000619379(transcript)|ensembl:ENST00000652446(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006952"(defense response)|go:"GO:0015031"(protein transport)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035375"(zymogen binding)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042494"(detection of bacterial lipoprotein)|go:"GO:0042589"(zymogen granule membrane)|go:"GO:0043152"(induction of bacterial agglutination)|go:"GO:0045087"(innate immune response)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070891"(lipoteichoic acid binding)|go:"GO:1904399"(heparan sulfate binding)|interpro:IPR000859(CUB)|interpro:IPR001190(Speract/scavenger receptor)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017448(Speract/scavenger receptor related)|interpro:IPR017977|interpro:IPR035914|interpro:IPR036772|interpro:IPR042235|mint:Q9UGM3|rcsb pdb:6SA4|rcsb pdb:6SA5|rcsb pdb:6SAN|reactome:R-HSA-5683826	-	disease:"Complement component C1q deficiency (C1QD) [MONDO:0013343]: a disorder caused by impaired activation of the complement classical pathway. It generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis."|complex-properties:The complex comprises of six heterotrimeric collagen-like triple helices, formed from triplets of the A, B, and C chains, that associate in their N-terminal half to form a stalk, then diverge to form individual stems, each terminating in a C-terminal globular domain. Each of the six heterotrimeric globular heads or domains is made up of the globular domains from one A, one B, and one C chain, each of which in turn has its own ligand specificity. The six collagen-like stalks appear to be fibril-like and exist in the central region. The collagen-like region and the globular heads can independently interact with a multiplicity of biological structures including pathogen-associated and cell associated molecules, also each of the individual globular head domains is capable of independently interacting with specific ligands. Chains A and B are disulfide-linked whilst the C chain forms a disulfide bond with the C chain of the next strand.     Molecular weight 460 kDa.|curated-complex:"Recognition unit of the classical pathway of complement which associates with the Ca2+ - dependent C1r(2)-C1s(2) tetramer to form C1 (CPX-1920), the first component of the classical complement system. The complex's role in C1 is the recognition of immune complexes, or other molecules, which trigger the classical pathway of the complement system. Independent of complement activation C1q appears to have additional roles in homeostasis and cellular development, superoxide (O2-) production by neutrophils, blood coagulation and neurological synapse pruning."|complex-assembly:Heterooctadecamer	-	figure legend:2, number 4|agonist:Ca2+|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/18	2021/01/01	-	rogid:A0Aw2F/rHW8mFmPDg4xOTy8NGzg9606	-	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P01024	uniprotkb:Q9UGM3	intact:EBI-905851|uniprotkb:A7E236|ensembl:ENSP00000245907	intact:EBI-1044970|uniprotkb:Q59EX0|uniprotkb:Q5JR26|uniprotkb:Q6MZN4|uniprotkb:Q96DU4|uniprotkb:Q9UGM2|uniprotkb:Q9UJ57|uniprotkb:Q9UKJ4|uniprotkb:Q9Y211|uniprotkb:Q9Y4V9|uniprotkb:A6NDG4|uniprotkb:A6NDJ5|uniprotkb:A8E4R5|uniprotkb:B1ARE7|uniprotkb:B1ARE8|uniprotkb:B1ARE9|uniprotkb:B1ARF0|uniprotkb:B7Z8Y2|uniprotkb:F8WEF7|ensembl:ENSP00000357905|ensembl:ENSP00000484603|ensembl:ENSP00000498825	psi-mi:co3_human(display_long)|uniprotkb:C3(gene name)|psi-mi:C3(display_short)|uniprotkb:CPAMD1(gene name synonym)|uniprotkb:C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1(gene name synonym)	psi-mi:dmbt1_human(display_long)|uniprotkb:Glycoprotein 340(gene name synonym)|uniprotkb:Surfactant pulmonary-associated D-binding protein(gene name synonym)|uniprotkb:Hensin(gene name synonym)|uniprotkb:DMBT1(gene name)|psi-mi:DMBT1(display_short)|uniprotkb:GP340(gene name synonym)|uniprotkb:Salivary agglutinin(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Reichhardt et al. (2011)	pubmed:22811680|imex:IM-28603	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26581857|imex:IM-28603-23	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000055.2|dip:DIP-35180N|ensembl:ENSG00000125730(gene)|ensembl:ENST00000245907(transcript)|go:"GO:0001798"(positive regulation of type IIa hypersensitivity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001970"(positive regulation of activation of membrane attack complex)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006956"(complement activation)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0009617"(response to bacterium)|go:"GO:0009986"(cell surface)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010828"(positive regulation of glucose transmembrane transport)|go:"GO:0010866"(regulation of triglyceride biosynthetic process)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0016322"(neuron remodeling)|go:"GO:0031715"(C5L2 anaphylatoxin chemotactic receptor binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0035846"(oviduct epithelium development)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0097278"(complement-dependent cytotoxicity)|go:"GO:0150062"(complement-mediated synapse pruning)|go:"GO:0150064"(vertebrate eye-specific patterning)|go:"GO:1905114"(cell surface receptor signaling pathway involved in cell-cell signaling)|go:"GO:2000427"(positive regulation of apoptotic cell clearance)|interpro:IPR000020(Anaphylatoxin/fibulin)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR001599(Alpha-2-macroglobulin)|interpro:IPR001840(Complement C3a/C4a/C5a anaphylatoxin)|interpro:IPR002890(Alpha-2-macroglobulin, N-terminal)|interpro:IPR008930(Terpenoid cylases/protein prenyltransferase alpha-alpha toroid)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR009048(Alpha-macroglobulin, receptor-binding)|interpro:IPR011625(Alpha-2-macroglobulin, N-terminal 2)|interpro:IPR011626(A-macroglobulin complement component)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR018081|interpro:IPR018933|interpro:IPR019742|interpro:IPR035711|interpro:IPR035815|interpro:IPR036595|interpro:IPR040839|interpro:IPR041425|interpro:IPR041555|mint:P01024|rcsb pdb:1C3D|rcsb pdb:1GHQ|rcsb pdb:1W2S|rcsb pdb:2A73|rcsb pdb:2A74|rcsb pdb:2GOX|rcsb pdb:2I07|rcsb pdb:2ICE|rcsb pdb:2ICF|rcsb pdb:2NOJ|rcsb pdb:2QKI|rcsb pdb:2WII|rcsb pdb:2WIN|rcsb pdb:2WY7|rcsb pdb:2WY8|rcsb pdb:2XQW|rcsb pdb:2XWB|rcsb pdb:2XWJ|rcsb pdb:3D5R|rcsb pdb:3D5S|rcsb pdb:3G6J|rcsb pdb:3L3O|rcsb pdb:3L5N|rcsb pdb:3NMS|rcsb pdb:3OED|rcsb pdb:3OHX|rcsb pdb:3OXU|rcsb pdb:3RJ3|rcsb pdb:3T4A|rcsb pdb:4HW5|rcsb pdb:4HWJ|rcsb pdb:4I6O|rcsb pdb:4M76|rcsb pdb:4ONT|rcsb pdb:4ZH1|rcsb pdb:5FO7|rcsb pdb:5FO8|rcsb pdb:5FO9|rcsb pdb:5FOA|rcsb pdb:5FOB|rcsb pdb:5NBQ|rcsb pdb:5O32|rcsb pdb:5O35|rcsb pdb:6EHG|rcsb pdb:6RMT|rcsb pdb:6RMU|rcsb pdb:6RUR|rcsb pdb:6RUV|rcsb pdb:6S0B|rcsb pdb:6YO6|reactome:R-HSA-173736|reactome:R-HSA-174577|reactome:R-HSA-198933|reactome:R-HSA-375276|reactome:R-HSA-381426|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-8957275|reactome:R-HSA-9660826|reactome:R-HSA-977606	refseq:NP_004397.2|refseq:NP_015568.2|refseq:NP_060049.2|refseq:XP_011537690.1|refseq:XP_011537693.1|refseq:XP_011537707.1|refseq:NP_001307573.1|dip:DIP-50763N|ensembl:ENSG00000187908(gene)|ensembl:ENST00000368909(transcript)|ensembl:ENST00000619379(transcript)|ensembl:ENST00000652446(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006952"(defense response)|go:"GO:0015031"(protein transport)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035375"(zymogen binding)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042494"(detection of bacterial lipoprotein)|go:"GO:0042589"(zymogen granule membrane)|go:"GO:0043152"(induction of bacterial agglutination)|go:"GO:0045087"(innate immune response)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070891"(lipoteichoic acid binding)|go:"GO:1904399"(heparan sulfate binding)|interpro:IPR000859(CUB)|interpro:IPR001190(Speract/scavenger receptor)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017448(Speract/scavenger receptor related)|interpro:IPR017977|interpro:IPR035914|interpro:IPR036772|interpro:IPR042235|mint:Q9UGM3|rcsb pdb:6SA4|rcsb pdb:6SA5|rcsb pdb:6SAN|reactome:R-HSA-5683826	-	-	-	figure legend:2, number 7|agonist:Ca2+|comment:weak binding|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/18	2021/01/01	rogid:6Axa89cCPpUXFsLnd7sCurZzLYI9606	rogid:A0Aw2F/rHW8mFmPDg4xOTy8NGzg9606	rigid:2T7d6BYhLAoeP6K13WBYQtelcog	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:28808"	uniprotkb:P11226	intact:EBI-25613000|chebi:"CHEBI:6684"|chebi:"CHEBI:25159"	intact:EBI-5325353|ensembl:ENSP00000363079|ensembl:ENSP00000502615|ensembl:ENSP00000502789|uniprotkb:Q4VB12|uniprotkb:Q4VB13|uniprotkb:Q86SI4|uniprotkb:Q96KE4|uniprotkb:Q96TF7|uniprotkb:Q96TF8|uniprotkb:Q96TF9|uniprotkb:Q4VB14|uniprotkb:Q5SQS3	psi-mi:mannan(display_short)|psi-mi:"CHEBI:28808"(display_long)|intact:Mannan(synonym)|intact:mannans(synonym)|intact:Mannoglycan(synonym)|intact:mannan(iupac name)	psi-mi:mbl2_human(display_long)|uniprotkb:MBL2(gene name)|psi-mi:MBL2(display_short)|uniprotkb:COLEC1(gene name synonym)|uniprotkb:MBL(gene name synonym)|uniprotkb:Collectin-1(gene name synonym)|uniprotkb:MBP1(gene name synonym)|uniprotkb:Mannan-binding protein(gene name synonym)|uniprotkb:Mannose-binding lectin(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Reichhardt et al. (2011)	pubmed:22811680|imex:IM-28603	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26581866|imex:IM-28603-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000165471(gene)|ensembl:ENST00000373968(transcript)|ensembl:ENST00000674931(transcript)|ensembl:ENST00000675947(transcript)|go:"GO:0001867"(complement activation, lectin pathway)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005537"(mannose binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0006953"(acute-phase response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008228"(opsonization)|go:"GO:0009986"(cell surface)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048525"(negative regulation of viral process)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR001304(C-type lectin)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR016186(C-type lectin-like)|refseq:XP_011538118.1|interpro:IPR018378|interpro:IPR033990|interpro:IPR037570|rcsb pdb:1HUP|interpro:IPR016187(C-type lectin fold)|reactome:R-HSA-166662|reactome:R-HSA-166663|refseq:NP_000233.1|refseq:XP_006717924.1|dip:DIP-61381N	-	-	-	figure legend:3A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/18	2021/01/01	-	rogid:uo0RM88uw3otObIVnOhUcOfW8yo9606	-	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:28808"	chebi:"CHEBI:37684"	intact:EBI-25613000|chebi:"CHEBI:6684"|chebi:"CHEBI:25159"	intact:EBI-14032013|chebi:"CHEBI:14575"|chebi:"CHEBI:33930"	psi-mi:mannan(display_short)|psi-mi:"CHEBI:28808"(display_long)|intact:Mannan(synonym)|intact:mannans(synonym)|intact:Mannoglycan(synonym)|intact:mannan(iupac name)	psi-mi:mannose(display_short)|psi-mi:"CHEBI:37684"(display_long)|intact:Man(synonym)|intact:mannose(synonym)|intact:manno-hexose(iupac name)|intact:mannose(iupac name)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Reichhardt et al. (2011)	pubmed:22811680|imex:IM-28603	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26581871|imex:IM-28603-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0328"(small molecule)	-	-	-	-	-	figure legend:3A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/18	2021/01/01	-	-	-	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:28808"	uniprotkb:P11226	intact:EBI-25613000|chebi:"CHEBI:6684"|chebi:"CHEBI:25159"	intact:EBI-5325353|ensembl:ENSP00000363079|ensembl:ENSP00000502615|ensembl:ENSP00000502789|uniprotkb:Q4VB12|uniprotkb:Q4VB13|uniprotkb:Q86SI4|uniprotkb:Q96KE4|uniprotkb:Q96TF7|uniprotkb:Q96TF8|uniprotkb:Q96TF9|uniprotkb:Q4VB14|uniprotkb:Q5SQS3	psi-mi:mannan(display_short)|psi-mi:"CHEBI:28808"(display_long)|intact:Mannan(synonym)|intact:mannans(synonym)|intact:Mannoglycan(synonym)|intact:mannan(iupac name)	psi-mi:mbl2_human(display_long)|uniprotkb:MBL2(gene name)|psi-mi:MBL2(display_short)|uniprotkb:COLEC1(gene name synonym)|uniprotkb:MBL(gene name synonym)|uniprotkb:Collectin-1(gene name synonym)|uniprotkb:MBP1(gene name synonym)|uniprotkb:Mannan-binding protein(gene name synonym)|uniprotkb:Mannose-binding lectin(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Reichhardt et al. (2011)	pubmed:22811680|imex:IM-28603	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26581871|imex:IM-28603-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000165471(gene)|ensembl:ENST00000373968(transcript)|ensembl:ENST00000674931(transcript)|ensembl:ENST00000675947(transcript)|go:"GO:0001867"(complement activation, lectin pathway)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005537"(mannose binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0006953"(acute-phase response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008228"(opsonization)|go:"GO:0009986"(cell surface)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048525"(negative regulation of viral process)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR001304(C-type lectin)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR016186(C-type lectin-like)|refseq:XP_011538118.1|interpro:IPR018378|interpro:IPR033990|interpro:IPR037570|rcsb pdb:1HUP|interpro:IPR016187(C-type lectin fold)|reactome:R-HSA-166662|reactome:R-HSA-166663|refseq:NP_000233.1|refseq:XP_006717924.1|dip:DIP-61381N	-	-	-	figure legend:3A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/18	2021/01/01	-	rogid:uo0RM88uw3otObIVnOhUcOfW8yo9606	-	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:28808"	chebi:"CHEBI:28009"	intact:EBI-25613000|chebi:"CHEBI:6684"|chebi:"CHEBI:25159"	intact:EBI-11787019|chebi:"CHEBI:44166"|chebi:"CHEBI:7169"|chebi:"CHEBI:21579"|chebi:"CHEBI:7140"	psi-mi:mannan(display_short)|psi-mi:"CHEBI:28808"(display_long)|intact:Mannan(synonym)|intact:mannans(synonym)|intact:Mannoglycan(synonym)|intact:mannan(iupac name)	psi-mi:n-acetyl-beta-d-glucosamine(display_short)|psi-mi:"CHEBI:28009"(display_long)|intact:2-Acetamido-2-deoxy-D-glucose(synonym)|intact:2-Acetylamino-2-deoxy-D-glucose(synonym)|intact:Acetylglucosamine(synonym)|intact:betaGlcNAc(synonym)|intact:GlcNAc-beta(synonym)|intact:N-Acetyl-beta-D-glucosamine(synonym)|intact:N-acetyl-beta-D-glucosamine(synonym)|intact:N-Acetyl-D-glucosamine(synonym)|intact:N-acetylglucosamine(synonym)|intact:2-acetamido-2-deoxy-beta-D-glucopyranose(iupac name)|intact:2-acetamido-2-deoxyhexopyranose(iupac name)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Reichhardt et al. (2011)	pubmed:22811680|imex:IM-28603	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26581877|imex:IM-28603-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0328"(small molecule)	-	-	-	-	-	figure legend:3A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/18	2021/01/01	-	-	-	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:28808"	uniprotkb:P11226	intact:EBI-25613000|chebi:"CHEBI:6684"|chebi:"CHEBI:25159"	intact:EBI-5325353|ensembl:ENSP00000363079|ensembl:ENSP00000502615|ensembl:ENSP00000502789|uniprotkb:Q4VB12|uniprotkb:Q4VB13|uniprotkb:Q86SI4|uniprotkb:Q96KE4|uniprotkb:Q96TF7|uniprotkb:Q96TF8|uniprotkb:Q96TF9|uniprotkb:Q4VB14|uniprotkb:Q5SQS3	psi-mi:mannan(display_short)|psi-mi:"CHEBI:28808"(display_long)|intact:Mannan(synonym)|intact:mannans(synonym)|intact:Mannoglycan(synonym)|intact:mannan(iupac name)	psi-mi:mbl2_human(display_long)|uniprotkb:MBL2(gene name)|psi-mi:MBL2(display_short)|uniprotkb:COLEC1(gene name synonym)|uniprotkb:MBL(gene name synonym)|uniprotkb:Collectin-1(gene name synonym)|uniprotkb:MBP1(gene name synonym)|uniprotkb:Mannan-binding protein(gene name synonym)|uniprotkb:Mannose-binding lectin(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Reichhardt et al. (2011)	pubmed:22811680|imex:IM-28603	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26581877|imex:IM-28603-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000165471(gene)|ensembl:ENST00000373968(transcript)|ensembl:ENST00000674931(transcript)|ensembl:ENST00000675947(transcript)|go:"GO:0001867"(complement activation, lectin pathway)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005537"(mannose binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0006953"(acute-phase response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008228"(opsonization)|go:"GO:0009986"(cell surface)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048525"(negative regulation of viral process)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR001304(C-type lectin)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR016186(C-type lectin-like)|refseq:XP_011538118.1|interpro:IPR018378|interpro:IPR033990|interpro:IPR037570|rcsb pdb:1HUP|interpro:IPR016187(C-type lectin fold)|reactome:R-HSA-166662|reactome:R-HSA-166663|refseq:NP_000233.1|refseq:XP_006717924.1|dip:DIP-61381N	-	-	-	figure legend:3A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/18	2021/01/01	-	rogid:uo0RM88uw3otObIVnOhUcOfW8yo9606	-	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q9UGM3	uniprotkb:P11226	intact:EBI-1044970|uniprotkb:Q59EX0|uniprotkb:Q5JR26|uniprotkb:Q6MZN4|uniprotkb:Q96DU4|uniprotkb:Q9UGM2|uniprotkb:Q9UJ57|uniprotkb:Q9UKJ4|uniprotkb:Q9Y211|uniprotkb:Q9Y4V9|uniprotkb:A6NDG4|uniprotkb:A6NDJ5|uniprotkb:A8E4R5|uniprotkb:B1ARE7|uniprotkb:B1ARE8|uniprotkb:B1ARE9|uniprotkb:B1ARF0|uniprotkb:B7Z8Y2|uniprotkb:F8WEF7|ensembl:ENSP00000357905|ensembl:ENSP00000484603|ensembl:ENSP00000498825	intact:EBI-5325353|ensembl:ENSP00000363079|ensembl:ENSP00000502615|ensembl:ENSP00000502789|uniprotkb:Q4VB12|uniprotkb:Q4VB13|uniprotkb:Q86SI4|uniprotkb:Q96KE4|uniprotkb:Q96TF7|uniprotkb:Q96TF8|uniprotkb:Q96TF9|uniprotkb:Q4VB14|uniprotkb:Q5SQS3	psi-mi:dmbt1_human(display_long)|uniprotkb:Glycoprotein 340(gene name synonym)|uniprotkb:Surfactant pulmonary-associated D-binding protein(gene name synonym)|uniprotkb:Hensin(gene name synonym)|uniprotkb:DMBT1(gene name)|psi-mi:DMBT1(display_short)|uniprotkb:GP340(gene name synonym)|uniprotkb:Salivary agglutinin(gene name synonym)	psi-mi:mbl2_human(display_long)|uniprotkb:MBL2(gene name)|psi-mi:MBL2(display_short)|uniprotkb:COLEC1(gene name synonym)|uniprotkb:MBL(gene name synonym)|uniprotkb:Collectin-1(gene name synonym)|uniprotkb:MBP1(gene name synonym)|uniprotkb:Mannan-binding protein(gene name synonym)|uniprotkb:Mannose-binding lectin(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Reichhardt et al. (2011)	pubmed:22811680|imex:IM-28603	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26581883|imex:IM-28603-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004397.2|refseq:NP_015568.2|refseq:NP_060049.2|refseq:XP_011537690.1|refseq:XP_011537693.1|refseq:XP_011537707.1|refseq:NP_001307573.1|dip:DIP-50763N|ensembl:ENSG00000187908(gene)|ensembl:ENST00000368909(transcript)|ensembl:ENST00000619379(transcript)|ensembl:ENST00000652446(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006952"(defense response)|go:"GO:0015031"(protein transport)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035375"(zymogen binding)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042494"(detection of bacterial lipoprotein)|go:"GO:0042589"(zymogen granule membrane)|go:"GO:0043152"(induction of bacterial agglutination)|go:"GO:0045087"(innate immune response)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070891"(lipoteichoic acid binding)|go:"GO:1904399"(heparan sulfate binding)|interpro:IPR000859(CUB)|interpro:IPR001190(Speract/scavenger receptor)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017448(Speract/scavenger receptor related)|interpro:IPR017977|interpro:IPR035914|interpro:IPR036772|interpro:IPR042235|mint:Q9UGM3|rcsb pdb:6SA4|rcsb pdb:6SA5|rcsb pdb:6SAN|reactome:R-HSA-5683826	ensembl:ENSG00000165471(gene)|ensembl:ENST00000373968(transcript)|ensembl:ENST00000674931(transcript)|ensembl:ENST00000675947(transcript)|go:"GO:0001867"(complement activation, lectin pathway)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005537"(mannose binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0006953"(acute-phase response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008228"(opsonization)|go:"GO:0009986"(cell surface)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048525"(negative regulation of viral process)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR001304(C-type lectin)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR016186(C-type lectin-like)|refseq:XP_011538118.1|interpro:IPR018378|interpro:IPR033990|interpro:IPR037570|rcsb pdb:1HUP|interpro:IPR016187(C-type lectin fold)|reactome:R-HSA-166662|reactome:R-HSA-166663|refseq:NP_000233.1|refseq:XP_006717924.1|dip:DIP-61381N	-	-	-	figure legend:3B|comment:The presence of mannose, GlcNAc, or glucose had no effect.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/18	2021/01/01	rogid:A0Aw2F/rHW8mFmPDg4xOTy8NGzg9606	rogid:uo0RM88uw3otObIVnOhUcOfW8yo9606	rigid:S8qzQKuHOki2BagQfeQDa7cRf4c	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:28808"	uniprotkb:O00187	intact:EBI-25613000|chebi:"CHEBI:6684"|chebi:"CHEBI:25159"	intact:EBI-7965040|uniprotkb:Q9UMV3|intact:MINT-7970114|uniprotkb:Q9ULC7|uniprotkb:Q9Y270|uniprotkb:A8MWJ2|uniprotkb:O75754|uniprotkb:Q96QG4|uniprotkb:Q9UBP3|uniprotkb:Q5TEQ5|uniprotkb:Q5TER0|uniprotkb:Q9H498|uniprotkb:Q9UC48|uniprotkb:A8K458|uniprotkb:Q9H499|uniprotkb:Q9BZH0|ensembl:ENSP00000383690	psi-mi:mannan(display_short)|psi-mi:"CHEBI:28808"(display_long)|intact:Mannan(synonym)|intact:mannans(synonym)|intact:Mannoglycan(synonym)|intact:mannan(iupac name)	psi-mi:masp2_human(display_long)|uniprotkb:MASP2(gene name)|psi-mi:MASP2(display_short)|uniprotkb:Mannose-binding protein-associated serine protease 2(gene name synonym)|uniprotkb:MBL-associated serine protease 2(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Reichhardt et al. (2011)	pubmed:22811680|imex:IM-28603	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26581888|imex:IM-28603-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_631947.1|refseq:NP_006601.2|ensembl:ENSG00000009724(gene)|ensembl:ENST00000400897(transcript)|go:"GO:0001855"(complement component C4b binding)|go:"GO:0001867"(complement activation, lectin pathway)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0008233"(peptidase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000859(CUB)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR018097|interpro:IPR033116|interpro:IPR035914|interpro:IPR035976|interpro:IPR037571|interpro:IPR043504|rcsb pdb:1Q3X|rcsb pdb:1SZB|rcsb pdb:1ZJK|rcsb pdb:3TVJ|rcsb pdb:4FXG|rcsb pdb:5JPM|reactome:R-HSA-166662|reactome:R-HSA-166663|reactome:R-HSA-2855086	-	-	comment:mint	figure legend:4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/18	2021/01/01	-	rogid:S48IDwjdZ8M6vIJD6iM0XplSN609606	-	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:28808"	uniprotkb:Q9UGM3	intact:EBI-25613000|chebi:"CHEBI:6684"|chebi:"CHEBI:25159"	intact:EBI-1044970|uniprotkb:Q59EX0|uniprotkb:Q5JR26|uniprotkb:Q6MZN4|uniprotkb:Q96DU4|uniprotkb:Q9UGM2|uniprotkb:Q9UJ57|uniprotkb:Q9UKJ4|uniprotkb:Q9Y211|uniprotkb:Q9Y4V9|uniprotkb:A6NDG4|uniprotkb:A6NDJ5|uniprotkb:A8E4R5|uniprotkb:B1ARE7|uniprotkb:B1ARE8|uniprotkb:B1ARE9|uniprotkb:B1ARF0|uniprotkb:B7Z8Y2|uniprotkb:F8WEF7|ensembl:ENSP00000357905|ensembl:ENSP00000484603|ensembl:ENSP00000498825	psi-mi:mannan(display_short)|psi-mi:"CHEBI:28808"(display_long)|intact:Mannan(synonym)|intact:mannans(synonym)|intact:Mannoglycan(synonym)|intact:mannan(iupac name)	psi-mi:dmbt1_human(display_long)|uniprotkb:Glycoprotein 340(gene name synonym)|uniprotkb:Surfactant pulmonary-associated D-binding protein(gene name synonym)|uniprotkb:Hensin(gene name synonym)|uniprotkb:DMBT1(gene name)|psi-mi:DMBT1(display_short)|uniprotkb:GP340(gene name synonym)|uniprotkb:Salivary agglutinin(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Reichhardt et al. (2011)	pubmed:22811680|imex:IM-28603	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26581888|imex:IM-28603-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_004397.2|refseq:NP_015568.2|refseq:NP_060049.2|refseq:XP_011537690.1|refseq:XP_011537693.1|refseq:XP_011537707.1|refseq:NP_001307573.1|dip:DIP-50763N|ensembl:ENSG00000187908(gene)|ensembl:ENST00000368909(transcript)|ensembl:ENST00000619379(transcript)|ensembl:ENST00000652446(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006952"(defense response)|go:"GO:0015031"(protein transport)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035375"(zymogen binding)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042494"(detection of bacterial lipoprotein)|go:"GO:0042589"(zymogen granule membrane)|go:"GO:0043152"(induction of bacterial agglutination)|go:"GO:0045087"(innate immune response)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070891"(lipoteichoic acid binding)|go:"GO:1904399"(heparan sulfate binding)|interpro:IPR000859(CUB)|interpro:IPR001190(Speract/scavenger receptor)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017448(Speract/scavenger receptor related)|interpro:IPR017977|interpro:IPR035914|interpro:IPR036772|interpro:IPR042235|mint:Q9UGM3|rcsb pdb:6SA4|rcsb pdb:6SA5|rcsb pdb:6SAN|reactome:R-HSA-5683826	-	-	-	figure legend:4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/18	2021/01/01	-	rogid:A0Aw2F/rHW8mFmPDg4xOTy8NGzg9606	-	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:28808"	uniprotkb:P11226	intact:EBI-25613000|chebi:"CHEBI:6684"|chebi:"CHEBI:25159"	intact:EBI-5325353|ensembl:ENSP00000363079|ensembl:ENSP00000502615|ensembl:ENSP00000502789|uniprotkb:Q4VB12|uniprotkb:Q4VB13|uniprotkb:Q86SI4|uniprotkb:Q96KE4|uniprotkb:Q96TF7|uniprotkb:Q96TF8|uniprotkb:Q96TF9|uniprotkb:Q4VB14|uniprotkb:Q5SQS3	psi-mi:mannan(display_short)|psi-mi:"CHEBI:28808"(display_long)|intact:Mannan(synonym)|intact:mannans(synonym)|intact:Mannoglycan(synonym)|intact:mannan(iupac name)	psi-mi:mbl2_human(display_long)|uniprotkb:MBL2(gene name)|psi-mi:MBL2(display_short)|uniprotkb:COLEC1(gene name synonym)|uniprotkb:MBL(gene name synonym)|uniprotkb:Collectin-1(gene name synonym)|uniprotkb:MBP1(gene name synonym)|uniprotkb:Mannan-binding protein(gene name synonym)|uniprotkb:Mannose-binding lectin(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Reichhardt et al. (2011)	pubmed:22811680|imex:IM-28603	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26581888|imex:IM-28603-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000165471(gene)|ensembl:ENST00000373968(transcript)|ensembl:ENST00000674931(transcript)|ensembl:ENST00000675947(transcript)|go:"GO:0001867"(complement activation, lectin pathway)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005537"(mannose binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0006953"(acute-phase response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008228"(opsonization)|go:"GO:0009986"(cell surface)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048525"(negative regulation of viral process)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR001304(C-type lectin)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR016186(C-type lectin-like)|refseq:XP_011538118.1|interpro:IPR018378|interpro:IPR033990|interpro:IPR037570|rcsb pdb:1HUP|interpro:IPR016187(C-type lectin fold)|reactome:R-HSA-166662|reactome:R-HSA-166663|refseq:NP_000233.1|refseq:XP_006717924.1|dip:DIP-61381N	-	-	-	figure legend:4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/18	2021/01/01	-	rogid:uo0RM88uw3otObIVnOhUcOfW8yo9606	-	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:28808"	uniprotkb:O00187	intact:EBI-25613000|chebi:"CHEBI:6684"|chebi:"CHEBI:25159"	intact:EBI-7965040|uniprotkb:Q9UMV3|intact:MINT-7970114|uniprotkb:Q9ULC7|uniprotkb:Q9Y270|uniprotkb:A8MWJ2|uniprotkb:O75754|uniprotkb:Q96QG4|uniprotkb:Q9UBP3|uniprotkb:Q5TEQ5|uniprotkb:Q5TER0|uniprotkb:Q9H498|uniprotkb:Q9UC48|uniprotkb:A8K458|uniprotkb:Q9H499|uniprotkb:Q9BZH0|ensembl:ENSP00000383690	psi-mi:mannan(display_short)|psi-mi:"CHEBI:28808"(display_long)|intact:Mannan(synonym)|intact:mannans(synonym)|intact:Mannoglycan(synonym)|intact:mannan(iupac name)	psi-mi:masp2_human(display_long)|uniprotkb:MASP2(gene name)|psi-mi:MASP2(display_short)|uniprotkb:Mannose-binding protein-associated serine protease 2(gene name synonym)|uniprotkb:MBL-associated serine protease 2(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Reichhardt et al. (2011)	pubmed:22811680|imex:IM-28603	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26581894|imex:IM-28603-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_631947.1|refseq:NP_006601.2|ensembl:ENSG00000009724(gene)|ensembl:ENST00000400897(transcript)|go:"GO:0001855"(complement component C4b binding)|go:"GO:0001867"(complement activation, lectin pathway)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0008233"(peptidase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000859(CUB)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR018097|interpro:IPR033116|interpro:IPR035914|interpro:IPR035976|interpro:IPR037571|interpro:IPR043504|rcsb pdb:1Q3X|rcsb pdb:1SZB|rcsb pdb:1ZJK|rcsb pdb:3TVJ|rcsb pdb:4FXG|rcsb pdb:5JPM|reactome:R-HSA-166662|reactome:R-HSA-166663|reactome:R-HSA-2855086	-	-	comment:mint	figure legend:4m|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/18	2021/01/01	-	rogid:S48IDwjdZ8M6vIJD6iM0XplSN609606	-	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:28808"	uniprotkb:P11226	intact:EBI-25613000|chebi:"CHEBI:6684"|chebi:"CHEBI:25159"	intact:EBI-5325353|ensembl:ENSP00000363079|ensembl:ENSP00000502615|ensembl:ENSP00000502789|uniprotkb:Q4VB12|uniprotkb:Q4VB13|uniprotkb:Q86SI4|uniprotkb:Q96KE4|uniprotkb:Q96TF7|uniprotkb:Q96TF8|uniprotkb:Q96TF9|uniprotkb:Q4VB14|uniprotkb:Q5SQS3	psi-mi:mannan(display_short)|psi-mi:"CHEBI:28808"(display_long)|intact:Mannan(synonym)|intact:mannans(synonym)|intact:Mannoglycan(synonym)|intact:mannan(iupac name)	psi-mi:mbl2_human(display_long)|uniprotkb:MBL2(gene name)|psi-mi:MBL2(display_short)|uniprotkb:COLEC1(gene name synonym)|uniprotkb:MBL(gene name synonym)|uniprotkb:Collectin-1(gene name synonym)|uniprotkb:MBP1(gene name synonym)|uniprotkb:Mannan-binding protein(gene name synonym)|uniprotkb:Mannose-binding lectin(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Reichhardt et al. (2011)	pubmed:22811680|imex:IM-28603	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26581894|imex:IM-28603-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000165471(gene)|ensembl:ENST00000373968(transcript)|ensembl:ENST00000674931(transcript)|ensembl:ENST00000675947(transcript)|go:"GO:0001867"(complement activation, lectin pathway)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005537"(mannose binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0006953"(acute-phase response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008228"(opsonization)|go:"GO:0009986"(cell surface)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048525"(negative regulation of viral process)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR001304(C-type lectin)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR016186(C-type lectin-like)|refseq:XP_011538118.1|interpro:IPR018378|interpro:IPR033990|interpro:IPR037570|rcsb pdb:1HUP|interpro:IPR016187(C-type lectin fold)|reactome:R-HSA-166662|reactome:R-HSA-166663|refseq:NP_000233.1|refseq:XP_006717924.1|dip:DIP-61381N	-	-	-	figure legend:4m|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/18	2021/01/01	-	rogid:uo0RM88uw3otObIVnOhUcOfW8yo9606	-	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)