#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P28026	uniprotkb:Q61091	intact:EBI-6257743	intact:EBI-6171689|ensembl:ENSMUSP00000039660|uniprotkb:A2RTK9	psi-mi:wnt8_xenla(display_long)|uniprotkb:wnt8(gene name)|psi-mi:wnt8(display_short)	psi-mi:fzd8_mouse(display_long)|uniprotkb:Fzd8(gene name)|psi-mi:Fzd8(display_short)	psi-mi:"MI:0114"(x-ray crystallography)	Janda et al. (2012)	imex:IM-27710|pubmed:22653731	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-25399943|wwpdb:4F0A|imex:IM-27710-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000578"(embryonic axis specification)|go:"GO:0002020"(protease binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005576"(extracellular region)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0014034"(neural crest cell fate commitment)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0044335"(canonical Wnt signaling pathway involved in neural crest cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060061"(Spemann organizer formation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:2000044"(negative regulation of cardiac cell fate specification)|interpro:IPR034312|rcsb pdb:4F0A|interpro:IPR005817(Wnt superfamily)|interpro:IPR013301(Wnt-8 protein)|interpro:IPR018161|refseq:NP_001081637.1|interpro:IPR043158	ensembl:ENSMUSG00000036904(gene)|ensembl:ENSMUST00000041080(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:1990851"(Wnt-Frizzled-LRP5/6 complex)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR036790|interpro:IPR041776|rcsb pdb:1IJY|rcsb pdb:4F0A|rcsb pdb:6TFB|rcsb pdb:6TFM|reactome:R-MMU-4608870|reactome:R-MMU-4641263|rcsb pdb:6AHY|refseq:NP_032084.2|dip:DIP-41258N	-	-	-	figure legend:Fig 1, S1, S2, Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/01/17	2020/01/17	rogid:i5DWY4D0O89KF0BJ91mXYV/TlcU8355	rogid:CBc7b1GULb5YzydnpCYV4uXaTmo10090	rigid:hmz1Tdxv9ouZDH1onuQKAZnEoJA	false	binding-associated region:23-338	binding-associated region:28-150	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28026	uniprotkb:Q61091	intact:EBI-6257743	intact:EBI-6171689|ensembl:ENSMUSP00000039660|uniprotkb:A2RTK9	psi-mi:wnt8_xenla(display_long)|uniprotkb:wnt8(gene name)|psi-mi:wnt8(display_short)	psi-mi:fzd8_mouse(display_long)|uniprotkb:Fzd8(gene name)|psi-mi:Fzd8(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	Janda et al. (2012)	imex:IM-27710|pubmed:22653731	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-25496062|imex:IM-27710-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000578"(embryonic axis specification)|go:"GO:0002020"(protease binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005576"(extracellular region)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0014034"(neural crest cell fate commitment)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0044335"(canonical Wnt signaling pathway involved in neural crest cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060061"(Spemann organizer formation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:2000044"(negative regulation of cardiac cell fate specification)|interpro:IPR034312|rcsb pdb:4F0A|interpro:IPR005817(Wnt superfamily)|interpro:IPR013301(Wnt-8 protein)|interpro:IPR018161|refseq:NP_001081637.1|interpro:IPR043158	ensembl:ENSMUSG00000036904(gene)|ensembl:ENSMUST00000041080(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:1990851"(Wnt-Frizzled-LRP5/6 complex)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR036790|interpro:IPR041776|rcsb pdb:1IJY|rcsb pdb:4F0A|rcsb pdb:6TFB|rcsb pdb:6TFM|reactome:R-MMU-4608870|reactome:R-MMU-4641263|rcsb pdb:6AHY|refseq:NP_032084.2|dip:DIP-41258N	-	-	-	figure legend:Fig 5|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/01/17	2020/03/30	rogid:i5DWY4D0O89KF0BJ91mXYV/TlcU8355	rogid:CBc7b1GULb5YzydnpCYV4uXaTmo10090	rigid:hmz1Tdxv9ouZDH1onuQKAZnEoJA	false	binding-associated region:248-338	binding-associated region:28-150	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28026	uniprotkb:Q61091	intact:EBI-6257743	intact:EBI-6171689|ensembl:ENSMUSP00000039660|uniprotkb:A2RTK9	psi-mi:wnt8_xenla(display_long)|uniprotkb:wnt8(gene name)|psi-mi:wnt8(display_short)	psi-mi:fzd8_mouse(display_long)|uniprotkb:Fzd8(gene name)|psi-mi:Fzd8(display_short)	psi-mi:"MI:0091"(chromatography technology)	Janda et al. (2012)	imex:IM-27710|pubmed:22653731	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-25496107|imex:IM-27710-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000578"(embryonic axis specification)|go:"GO:0002020"(protease binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005576"(extracellular region)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0014034"(neural crest cell fate commitment)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0044335"(canonical Wnt signaling pathway involved in neural crest cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060061"(Spemann organizer formation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:2000044"(negative regulation of cardiac cell fate specification)|interpro:IPR034312|rcsb pdb:4F0A|interpro:IPR005817(Wnt superfamily)|interpro:IPR013301(Wnt-8 protein)|interpro:IPR018161|refseq:NP_001081637.1|interpro:IPR043158	ensembl:ENSMUSG00000036904(gene)|ensembl:ENSMUST00000041080(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:1990851"(Wnt-Frizzled-LRP5/6 complex)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR036790|interpro:IPR041776|rcsb pdb:1IJY|rcsb pdb:4F0A|rcsb pdb:6TFB|rcsb pdb:6TFM|reactome:R-MMU-4608870|reactome:R-MMU-4641263|rcsb pdb:6AHY|refseq:NP_032084.2|dip:DIP-41258N	-	-	-	figure legend:Fig 1, Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/01/17	2020/03/30	rogid:i5DWY4D0O89KF0BJ91mXYV/TlcU8355	rogid:CBc7b1GULb5YzydnpCYV4uXaTmo10090	rigid:hmz1Tdxv9ouZDH1onuQKAZnEoJA	false	binding-associated region:28-338	binding-associated region:28-150	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)