#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P02918	uniprotkb:P0AD65	intact:EBI-1126191|uniprotkb:P76688|uniprotkb:Q2M761|ensemblbacteria:AAC76421|ensemblbacteria:BAE77895	intact:EBI-1124032|uniprotkb:P08150|ensemblbacteria:BAA35282|ensemblbacteria:AAC73736	psi-mi:pbpa_ecoli(display_long)|uniprotkb:mrcA(gene name)|psi-mi:mrcA(display_short)|uniprotkb:ponA(gene name synonym)|uniprotkb:b3396(locus name)|uniprotkb:JW3359(locus name)	psi-mi:mrda_ecoli(display_long)|uniprotkb:mrdA(gene name)|psi-mi:mrdA(display_short)|uniprotkb:pbpA(gene name synonym)|uniprotkb:b0635(locus name)|uniprotkb:JW0630(locus name)|uniprotkb:Penicillin-binding protein 2(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Banzhaf et al. (2012)	imex:IM-28369|pubmed:22606933	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-25757068|imex:IM-28369-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:WP_001336003.1|refseq:NP_417855.4|interpro:IPR036950|ensemblbacteria:AAC76421(transcript)|ensemblbacteria:b3396(gene)|ensemblbacteria:BAE77895(gene)|ensemblbacteria:BAE77895(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008658"(penicillin binding)|go:"GO:0008955"(peptidoglycan glycosyltransferase activity)|go:"GO:0009002"(serine-type D-Ala-D-Ala carboxypeptidase activity)|go:"GO:0009252"(peptidoglycan biosynthetic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0046677"(response to antibiotic)|go:"GO:0071555"(cell wall organization)|interpro:IPR001264(Glycosyl transferase, family 51)|interpro:IPR001460(Penicillin-binding protein, transpeptidase)|interpro:IPR012338(Beta-lactamase-type transpeptidase fold)|interpro:IPR023346|interpro:IPR031376|dip:DIP-10251N	refseq:WP_000776191.1|ensemblbacteria:AAC73736(transcript)|ensemblbacteria:b0635(gene)|ensemblbacteria:BAA35282(gene)|ensemblbacteria:BAA35282(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008658"(penicillin binding)|go:"GO:0009002"(serine-type D-Ala-D-Ala carboxypeptidase activity)|go:"GO:0009252"(peptidoglycan biosynthetic process)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|go:"GO:0046677"(response to antibiotic)|go:"GO:0071555"(cell wall organization)|go:"GO:0071972"(peptidoglycan L,D-transpeptidase activity)|interpro:IPR001460(Penicillin-binding protein, transpeptidase)|interpro:IPR005311(Penicillin-binding protein, dimerisation domain)|interpro:IPR012338(Beta-lactamase-type transpeptidase fold)|interpro:IPR017790(Penicillin-binding protein 2)|interpro:IPR036138|rcsb pdb:6G9F|rcsb pdb:6G9P|rcsb pdb:6G9S|refseq:NP_415168.1|dip:DIP-48190N	go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/07/15	2020/07/16	rogid:RG1QDvz7tvyKqgMO77s89MN2aJQ83333	rogid:jXQk50Kk4S5R2GvMLplRXkb5uD883333	rigid:mojN0ZQbAFCVYsm9FiWoHwjPd+M	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P02918	uniprotkb:P0AD65	intact:EBI-1126191|uniprotkb:P76688|uniprotkb:Q2M761|ensemblbacteria:AAC76421|ensemblbacteria:BAE77895	intact:EBI-1124032|uniprotkb:P08150|ensemblbacteria:BAA35282|ensemblbacteria:AAC73736	psi-mi:pbpa_ecoli(display_long)|uniprotkb:mrcA(gene name)|psi-mi:mrcA(display_short)|uniprotkb:ponA(gene name synonym)|uniprotkb:b3396(locus name)|uniprotkb:JW3359(locus name)	psi-mi:mrda_ecoli(display_long)|uniprotkb:mrdA(gene name)|psi-mi:mrdA(display_short)|uniprotkb:pbpA(gene name synonym)|uniprotkb:b0635(locus name)|uniprotkb:JW0630(locus name)|uniprotkb:Penicillin-binding protein 2(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Banzhaf et al. (2012)	imex:IM-28369|pubmed:22606933	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-25757075|imex:IM-28369-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:WP_001336003.1|refseq:NP_417855.4|interpro:IPR036950|ensemblbacteria:AAC76421(transcript)|ensemblbacteria:b3396(gene)|ensemblbacteria:BAE77895(gene)|ensemblbacteria:BAE77895(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008658"(penicillin binding)|go:"GO:0008955"(peptidoglycan glycosyltransferase activity)|go:"GO:0009002"(serine-type D-Ala-D-Ala carboxypeptidase activity)|go:"GO:0009252"(peptidoglycan biosynthetic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0046677"(response to antibiotic)|go:"GO:0071555"(cell wall organization)|interpro:IPR001264(Glycosyl transferase, family 51)|interpro:IPR001460(Penicillin-binding protein, transpeptidase)|interpro:IPR012338(Beta-lactamase-type transpeptidase fold)|interpro:IPR023346|interpro:IPR031376|dip:DIP-10251N	refseq:WP_000776191.1|ensemblbacteria:AAC73736(transcript)|ensemblbacteria:b0635(gene)|ensemblbacteria:BAA35282(gene)|ensemblbacteria:BAA35282(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008658"(penicillin binding)|go:"GO:0009002"(serine-type D-Ala-D-Ala carboxypeptidase activity)|go:"GO:0009252"(peptidoglycan biosynthetic process)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|go:"GO:0046677"(response to antibiotic)|go:"GO:0071555"(cell wall organization)|go:"GO:0071972"(peptidoglycan L,D-transpeptidase activity)|interpro:IPR001460(Penicillin-binding protein, transpeptidase)|interpro:IPR005311(Penicillin-binding protein, dimerisation domain)|interpro:IPR012338(Beta-lactamase-type transpeptidase fold)|interpro:IPR017790(Penicillin-binding protein 2)|interpro:IPR036138|rcsb pdb:6G9F|rcsb pdb:6G9P|rcsb pdb:6G9S|refseq:NP_415168.1|dip:DIP-48190N	go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/07/15	2020/07/16	rogid:RG1QDvz7tvyKqgMO77s89MN2aJQ83333	rogid:jXQk50Kk4S5R2GvMLplRXkb5uD883333	rigid:mojN0ZQbAFCVYsm9FiWoHwjPd+M	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P02918	uniprotkb:P0AD65	intact:EBI-1126191|uniprotkb:P76688|uniprotkb:Q2M761|ensemblbacteria:AAC76421|ensemblbacteria:BAE77895	intact:EBI-1124032|uniprotkb:P08150|ensemblbacteria:BAA35282|ensemblbacteria:AAC73736	psi-mi:pbpa_ecoli(display_long)|uniprotkb:mrcA(gene name)|psi-mi:mrcA(display_short)|uniprotkb:ponA(gene name synonym)|uniprotkb:b3396(locus name)|uniprotkb:JW3359(locus name)	psi-mi:mrda_ecoli(display_long)|uniprotkb:mrdA(gene name)|psi-mi:mrdA(display_short)|uniprotkb:pbpA(gene name synonym)|uniprotkb:b0635(locus name)|uniprotkb:JW0630(locus name)|uniprotkb:Penicillin-binding protein 2(gene name synonym)	psi-mi:"MI:0014"(adenylate cyclase complementation)	Banzhaf et al. (2012)	imex:IM-28369|pubmed:22606933	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-25757087|imex:IM-28369-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:WP_001336003.1|refseq:NP_417855.4|interpro:IPR036950|ensemblbacteria:AAC76421(transcript)|ensemblbacteria:b3396(gene)|ensemblbacteria:BAE77895(gene)|ensemblbacteria:BAE77895(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008658"(penicillin binding)|go:"GO:0008955"(peptidoglycan glycosyltransferase activity)|go:"GO:0009002"(serine-type D-Ala-D-Ala carboxypeptidase activity)|go:"GO:0009252"(peptidoglycan biosynthetic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0046677"(response to antibiotic)|go:"GO:0071555"(cell wall organization)|interpro:IPR001264(Glycosyl transferase, family 51)|interpro:IPR001460(Penicillin-binding protein, transpeptidase)|interpro:IPR012338(Beta-lactamase-type transpeptidase fold)|interpro:IPR023346|interpro:IPR031376|dip:DIP-10251N	refseq:WP_000776191.1|ensemblbacteria:AAC73736(transcript)|ensemblbacteria:b0635(gene)|ensemblbacteria:BAA35282(gene)|ensemblbacteria:BAA35282(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008658"(penicillin binding)|go:"GO:0009002"(serine-type D-Ala-D-Ala carboxypeptidase activity)|go:"GO:0009252"(peptidoglycan biosynthetic process)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|go:"GO:0046677"(response to antibiotic)|go:"GO:0071555"(cell wall organization)|go:"GO:0071972"(peptidoglycan L,D-transpeptidase activity)|interpro:IPR001460(Penicillin-binding protein, transpeptidase)|interpro:IPR005311(Penicillin-binding protein, dimerisation domain)|interpro:IPR012338(Beta-lactamase-type transpeptidase fold)|interpro:IPR017790(Penicillin-binding protein 2)|interpro:IPR036138|rcsb pdb:6G9F|rcsb pdb:6G9P|rcsb pdb:6G9S|refseq:NP_415168.1|dip:DIP-48190N	go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2020/07/15	2020/07/16	rogid:RG1QDvz7tvyKqgMO77s89MN2aJQ83333	rogid:jXQk50Kk4S5R2GvMLplRXkb5uD883333	rigid:mojN0ZQbAFCVYsm9FiWoHwjPd+M	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02918	uniprotkb:P0AD65	intact:EBI-1126191|uniprotkb:P76688|uniprotkb:Q2M761|ensemblbacteria:AAC76421|ensemblbacteria:BAE77895	intact:EBI-1124032|uniprotkb:P08150|ensemblbacteria:BAA35282|ensemblbacteria:AAC73736	psi-mi:pbpa_ecoli(display_long)|uniprotkb:mrcA(gene name)|psi-mi:mrcA(display_short)|uniprotkb:ponA(gene name synonym)|uniprotkb:b3396(locus name)|uniprotkb:JW3359(locus name)	psi-mi:mrda_ecoli(display_long)|uniprotkb:mrdA(gene name)|psi-mi:mrdA(display_short)|uniprotkb:pbpA(gene name synonym)|uniprotkb:b0635(locus name)|uniprotkb:JW0630(locus name)|uniprotkb:Penicillin-binding protein 2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Banzhaf et al. (2012)	imex:IM-28369|pubmed:22606933	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-25757098|imex:IM-28369-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:WP_001336003.1|refseq:NP_417855.4|interpro:IPR036950|ensemblbacteria:AAC76421(transcript)|ensemblbacteria:b3396(gene)|ensemblbacteria:BAE77895(gene)|ensemblbacteria:BAE77895(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008658"(penicillin binding)|go:"GO:0008955"(peptidoglycan glycosyltransferase activity)|go:"GO:0009002"(serine-type D-Ala-D-Ala carboxypeptidase activity)|go:"GO:0009252"(peptidoglycan biosynthetic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0046677"(response to antibiotic)|go:"GO:0071555"(cell wall organization)|interpro:IPR001264(Glycosyl transferase, family 51)|interpro:IPR001460(Penicillin-binding protein, transpeptidase)|interpro:IPR012338(Beta-lactamase-type transpeptidase fold)|interpro:IPR023346|interpro:IPR031376|dip:DIP-10251N	refseq:WP_000776191.1|ensemblbacteria:AAC73736(transcript)|ensemblbacteria:b0635(gene)|ensemblbacteria:BAA35282(gene)|ensemblbacteria:BAA35282(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008658"(penicillin binding)|go:"GO:0009002"(serine-type D-Ala-D-Ala carboxypeptidase activity)|go:"GO:0009252"(peptidoglycan biosynthetic process)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|go:"GO:0046677"(response to antibiotic)|go:"GO:0071555"(cell wall organization)|go:"GO:0071972"(peptidoglycan L,D-transpeptidase activity)|interpro:IPR001460(Penicillin-binding protein, transpeptidase)|interpro:IPR005311(Penicillin-binding protein, dimerisation domain)|interpro:IPR012338(Beta-lactamase-type transpeptidase fold)|interpro:IPR017790(Penicillin-binding protein 2)|interpro:IPR036138|rcsb pdb:6G9F|rcsb pdb:6G9P|rcsb pdb:6G9S|refseq:NP_415168.1|dip:DIP-48190N	go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2020/07/15	2020/07/16	rogid:RG1QDvz7tvyKqgMO77s89MN2aJQ83333	rogid:jXQk50Kk4S5R2GvMLplRXkb5uD883333	rigid:mojN0ZQbAFCVYsm9FiWoHwjPd+M	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
chebi:"CHEBI:28971"	uniprotkb:P02918	intact:EBI-26362112|chebi:"CHEBI:40648"|chebi:"CHEBI:45042"|chebi:"CHEBI:2683"|chebi:"CHEBI:22536"	intact:EBI-1126191|uniprotkb:P76688|uniprotkb:Q2M761|ensemblbacteria:AAC76421|ensemblbacteria:BAE77895	psi-mi:ampicillin(display_short)|psi-mi:"CHEBI:28971"(display_long)|intact:aminobenzylpenicillin(synonym)|intact:AMP(synonym)|intact:ampicilina(synonym)|intact:"(2S,5R,6R)-6-{[(2R)-2-amino-2-phenylacetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid"(synonym)|intact:"(2S,5R,6R)-6-{[(2R)-2-AMINO-2-PHENYLETHANOYL]AMINO}-3,3-DIMETHYL-7-OXO-4-THIA-1-AZABICYCLO[3.2.0]HEPTANE-2-CARBOXYLIC ACID"(synonym)|intact:"(2S,6R)-6-{[(2R)-2-amino-2-phenylethanoyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid"(synonym)|intact:"6-(D-(2-amino-2-phenylacetamido))-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid"(synonym)|intact:ABPC(synonym)|intact:Ampicillin(synonym)|intact:ampicillin(synonym)|intact:ampicillin acid(synonym)|intact:ampicillin anhydrous(synonym)|intact:ampicilline(synonym)|intact:ampicillinum(synonym)|intact:Anhydrous ampicillin(synonym)|intact:AP(synonym)|intact:"D-(-)-6-(alpha-aminophenylacetamido)penicillanic acid"(synonym)|intact:"D-(-)-ampicillin"(synonym)|intact:"6beta-[(2R)-2-amino-2-phenylacetamido]-2,2-dimethylpenam-3alpha-carboxylic acid"(iupac name)	psi-mi:pbpa_ecoli(display_long)|uniprotkb:mrcA(gene name)|psi-mi:mrcA(display_short)|uniprotkb:ponA(gene name synonym)|uniprotkb:b3396(locus name)|uniprotkb:JW3359(locus name)	psi-mi:"MI:0047"(far western blotting)	Banzhaf et al. (2012)	imex:IM-28369|pubmed:22606933	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26362107|imex:IM-28369-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:WP_001336003.1|refseq:NP_417855.4|interpro:IPR036950|ensemblbacteria:AAC76421(transcript)|ensemblbacteria:b3396(gene)|ensemblbacteria:BAE77895(gene)|ensemblbacteria:BAE77895(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008658"(penicillin binding)|go:"GO:0008955"(peptidoglycan glycosyltransferase activity)|go:"GO:0009002"(serine-type D-Ala-D-Ala carboxypeptidase activity)|go:"GO:0009252"(peptidoglycan biosynthetic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0046677"(response to antibiotic)|go:"GO:0071555"(cell wall organization)|interpro:IPR001264(Glycosyl transferase, family 51)|interpro:IPR001460(Penicillin-binding protein, transpeptidase)|interpro:IPR012338(Beta-lactamase-type transpeptidase fold)|interpro:IPR023346|interpro:IPR031376|dip:DIP-10251N	go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/07/15	2020/10/01	-	rogid:RG1QDvz7tvyKqgMO77s89MN2aJQ83333	-	false	biotin tag:?-?	his tag:n-n	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:P0AD65	uniprotkb:P02918	intact:EBI-1124032|uniprotkb:P08150|ensemblbacteria:BAA35282|ensemblbacteria:AAC73736	intact:EBI-1126191|uniprotkb:P76688|uniprotkb:Q2M761|ensemblbacteria:AAC76421|ensemblbacteria:BAE77895	psi-mi:mrda_ecoli(display_long)|uniprotkb:mrdA(gene name)|psi-mi:mrdA(display_short)|uniprotkb:pbpA(gene name synonym)|uniprotkb:b0635(locus name)|uniprotkb:JW0630(locus name)|uniprotkb:Penicillin-binding protein 2(gene name synonym)	psi-mi:pbpa_ecoli(display_long)|uniprotkb:mrcA(gene name)|psi-mi:mrcA(display_short)|uniprotkb:ponA(gene name synonym)|uniprotkb:b3396(locus name)|uniprotkb:JW3359(locus name)	psi-mi:"MI:0051"(fluorescence technology)	Banzhaf et al. (2012)	imex:IM-28369|pubmed:22606933	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26362161|imex:IM-28369-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:WP_000776191.1|ensemblbacteria:AAC73736(transcript)|ensemblbacteria:b0635(gene)|ensemblbacteria:BAA35282(gene)|ensemblbacteria:BAA35282(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008658"(penicillin binding)|go:"GO:0009002"(serine-type D-Ala-D-Ala carboxypeptidase activity)|go:"GO:0009252"(peptidoglycan biosynthetic process)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|go:"GO:0046677"(response to antibiotic)|go:"GO:0071555"(cell wall organization)|go:"GO:0071972"(peptidoglycan L,D-transpeptidase activity)|interpro:IPR001460(Penicillin-binding protein, transpeptidase)|interpro:IPR005311(Penicillin-binding protein, dimerisation domain)|interpro:IPR012338(Beta-lactamase-type transpeptidase fold)|interpro:IPR017790(Penicillin-binding protein 2)|interpro:IPR036138|rcsb pdb:6G9F|rcsb pdb:6G9P|rcsb pdb:6G9S|refseq:NP_415168.1|dip:DIP-48190N	refseq:WP_001336003.1|refseq:NP_417855.4|interpro:IPR036950|ensemblbacteria:AAC76421(transcript)|ensemblbacteria:b3396(gene)|ensemblbacteria:BAE77895(gene)|ensemblbacteria:BAE77895(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008658"(penicillin binding)|go:"GO:0008955"(peptidoglycan glycosyltransferase activity)|go:"GO:0009002"(serine-type D-Ala-D-Ala carboxypeptidase activity)|go:"GO:0009252"(peptidoglycan biosynthetic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0046677"(response to antibiotic)|go:"GO:0071555"(cell wall organization)|interpro:IPR001264(Glycosyl transferase, family 51)|interpro:IPR001460(Penicillin-binding protein, transpeptidase)|interpro:IPR012338(Beta-lactamase-type transpeptidase fold)|interpro:IPR023346|interpro:IPR031376|dip:DIP-10251N	-	-	-	figure legend:Fig. 6A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/07/15	2020/09/30	rogid:jXQk50Kk4S5R2GvMLplRXkb5uD883333	rogid:RG1QDvz7tvyKqgMO77s89MN2aJQ83333	-	false	-	-	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
chebi:"CHEBI:17334"	uniprotkb:P0AD65	intact:EBI-26362152|chebi:"CHEBI:7961"|chebi:"CHEBI:14742"|chebi:"CHEBI:25869"	intact:EBI-1124032|uniprotkb:P08150|ensemblbacteria:BAA35282|ensemblbacteria:AAC73736	psi-mi:penicillin(display_short)|psi-mi:"CHEBI:17334"(display_long)|intact:Penicillin(synonym)|intact:penicillins(synonym)|intact:penicillins(iupac name)	psi-mi:mrda_ecoli(display_long)|uniprotkb:mrdA(gene name)|psi-mi:mrdA(display_short)|uniprotkb:pbpA(gene name synonym)|uniprotkb:b0635(locus name)|uniprotkb:JW0630(locus name)|uniprotkb:Penicillin-binding protein 2(gene name synonym)	psi-mi:"MI:0051"(fluorescence technology)	Banzhaf et al. (2012)	imex:IM-28369|pubmed:22606933	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26362161|imex:IM-28369-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:WP_000776191.1|ensemblbacteria:AAC73736(transcript)|ensemblbacteria:b0635(gene)|ensemblbacteria:BAA35282(gene)|ensemblbacteria:BAA35282(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008658"(penicillin binding)|go:"GO:0009002"(serine-type D-Ala-D-Ala carboxypeptidase activity)|go:"GO:0009252"(peptidoglycan biosynthetic process)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|go:"GO:0046677"(response to antibiotic)|go:"GO:0071555"(cell wall organization)|go:"GO:0071972"(peptidoglycan L,D-transpeptidase activity)|interpro:IPR001460(Penicillin-binding protein, transpeptidase)|interpro:IPR005311(Penicillin-binding protein, dimerisation domain)|interpro:IPR012338(Beta-lactamase-type transpeptidase fold)|interpro:IPR017790(Penicillin-binding protein 2)|interpro:IPR036138|rcsb pdb:6G9F|rcsb pdb:6G9P|rcsb pdb:6G9S|refseq:NP_415168.1|dip:DIP-48190N	-	-	-	figure legend:Fig. 6A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/07/15	2020/09/30	-	rogid:jXQk50Kk4S5R2GvMLplRXkb5uD883333	-	false	bodipy label:?-?	-	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
chebi:"CHEBI:3507"	uniprotkb:P0AD65	intact:EBI-26362192	intact:EBI-1124032|uniprotkb:P08150|ensemblbacteria:BAA35282|ensemblbacteria:AAC73736	psi-mi:cefsulodin(display_short)|psi-mi:"CHEBI:3507"(display_long)|intact:Cefsulodin(synonym)|intact:cefsulodin(synonym)|intact:cefsulodine(synonym)|intact:cefsulodino(synonym)|intact:cefsulodinum(synonym)|intact:"(6R,7R)-3-[(4-carbamoylpyridinium-1-yl)methyl]-8-oxo-7-{[(2R)-2-phenyl-2-sulfoacetyl]amino}-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate"(iupac name)|intact:"7beta-{[(2R)-2-phenyl-2-sulfoacetyl]amino}-3-(4-carbamoylpyridinium-1-yl)methyl-3,4-didehydrocepham-4-carboxylate"(iupac name)	psi-mi:mrda_ecoli(display_long)|uniprotkb:mrdA(gene name)|psi-mi:mrdA(display_short)|uniprotkb:pbpA(gene name synonym)|uniprotkb:b0635(locus name)|uniprotkb:JW0630(locus name)|uniprotkb:Penicillin-binding protein 2(gene name synonym)	psi-mi:"MI:0051"(fluorescence technology)	Banzhaf et al. (2012)	imex:IM-28369|pubmed:22606933	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26362201|imex:IM-28369-12	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:WP_000776191.1|ensemblbacteria:AAC73736(transcript)|ensemblbacteria:b0635(gene)|ensemblbacteria:BAA35282(gene)|ensemblbacteria:BAA35282(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008658"(penicillin binding)|go:"GO:0009002"(serine-type D-Ala-D-Ala carboxypeptidase activity)|go:"GO:0009252"(peptidoglycan biosynthetic process)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|go:"GO:0046677"(response to antibiotic)|go:"GO:0071555"(cell wall organization)|go:"GO:0071972"(peptidoglycan L,D-transpeptidase activity)|interpro:IPR001460(Penicillin-binding protein, transpeptidase)|interpro:IPR005311(Penicillin-binding protein, dimerisation domain)|interpro:IPR012338(Beta-lactamase-type transpeptidase fold)|interpro:IPR017790(Penicillin-binding protein 2)|interpro:IPR036138|rcsb pdb:6G9F|rcsb pdb:6G9P|rcsb pdb:6G9S|refseq:NP_415168.1|dip:DIP-48190N	-	-	-	figure legend:Fig. 6A|comment:Cefsulodin specifically inhibits activity of PBP1A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/07/15	2020/09/30	-	rogid:jXQk50Kk4S5R2GvMLplRXkb5uD883333	-	false	-	-	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
chebi:"CHEBI:3507"	chebi:"CHEBI:17334"	intact:EBI-26362192	intact:EBI-26362152|chebi:"CHEBI:7961"|chebi:"CHEBI:14742"|chebi:"CHEBI:25869"	psi-mi:cefsulodin(display_short)|psi-mi:"CHEBI:3507"(display_long)|intact:Cefsulodin(synonym)|intact:cefsulodin(synonym)|intact:cefsulodine(synonym)|intact:cefsulodino(synonym)|intact:cefsulodinum(synonym)|intact:"(6R,7R)-3-[(4-carbamoylpyridinium-1-yl)methyl]-8-oxo-7-{[(2R)-2-phenyl-2-sulfoacetyl]amino}-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate"(iupac name)|intact:"7beta-{[(2R)-2-phenyl-2-sulfoacetyl]amino}-3-(4-carbamoylpyridinium-1-yl)methyl-3,4-didehydrocepham-4-carboxylate"(iupac name)	psi-mi:penicillin(display_short)|psi-mi:"CHEBI:17334"(display_long)|intact:Penicillin(synonym)|intact:penicillins(synonym)|intact:penicillins(iupac name)	psi-mi:"MI:0051"(fluorescence technology)	Banzhaf et al. (2012)	imex:IM-28369|pubmed:22606933	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26362201|imex:IM-28369-12	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0328"(small molecule)	-	-	-	-	-	figure legend:Fig. 6A|comment:Cefsulodin specifically inhibits activity of PBP1A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/07/15	2020/09/30	-	-	-	false	-	bodipy label:?-?	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
chebi:"CHEBI:51208"	uniprotkb:P02918	intact:EBI-26362208	intact:EBI-1126191|uniprotkb:P76688|uniprotkb:Q2M761|ensemblbacteria:AAC76421|ensemblbacteria:BAE77895	psi-mi:mecillinam(display_short)|psi-mi:"CHEBI:51208"(display_long)|intact:"(2S,5R,6R)-6-[(azepan-1-ylmethylidene)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid"(synonym)|intact:amdinocillin(synonym)|intact:Coactin(synonym)|intact:mecilinamo(synonym)|intact:mecillinam(synonym)|intact:mecillinamum(synonym)|intact:penicillin HX(synonym)|intact:"6beta-{[(azepan-1-yl)methylidene]amino}-2,2-dimethylpenam-3alpha-carboxylic acid"(iupac name)	psi-mi:pbpa_ecoli(display_long)|uniprotkb:mrcA(gene name)|psi-mi:mrcA(display_short)|uniprotkb:ponA(gene name synonym)|uniprotkb:b3396(locus name)|uniprotkb:JW3359(locus name)	psi-mi:"MI:0051"(fluorescence technology)	Banzhaf et al. (2012)	imex:IM-28369|pubmed:22606933	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26362218|imex:IM-28369-14	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:WP_001336003.1|refseq:NP_417855.4|interpro:IPR036950|ensemblbacteria:AAC76421(transcript)|ensemblbacteria:b3396(gene)|ensemblbacteria:BAE77895(gene)|ensemblbacteria:BAE77895(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008658"(penicillin binding)|go:"GO:0008955"(peptidoglycan glycosyltransferase activity)|go:"GO:0009002"(serine-type D-Ala-D-Ala carboxypeptidase activity)|go:"GO:0009252"(peptidoglycan biosynthetic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0046677"(response to antibiotic)|go:"GO:0071555"(cell wall organization)|interpro:IPR001264(Glycosyl transferase, family 51)|interpro:IPR001460(Penicillin-binding protein, transpeptidase)|interpro:IPR012338(Beta-lactamase-type transpeptidase fold)|interpro:IPR023346|interpro:IPR031376|dip:DIP-10251N	-	-	-	figure legend:Fig. 6A|comment:Mecillinam specifically inhibits activity of PBP2.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/07/15	2020/09/30	-	rogid:RG1QDvz7tvyKqgMO77s89MN2aJQ83333	-	false	-	-	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
chebi:"CHEBI:51208"	chebi:"CHEBI:17334"	intact:EBI-26362208	intact:EBI-26362152|chebi:"CHEBI:7961"|chebi:"CHEBI:14742"|chebi:"CHEBI:25869"	psi-mi:mecillinam(display_short)|psi-mi:"CHEBI:51208"(display_long)|intact:"(2S,5R,6R)-6-[(azepan-1-ylmethylidene)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid"(synonym)|intact:amdinocillin(synonym)|intact:Coactin(synonym)|intact:mecilinamo(synonym)|intact:mecillinam(synonym)|intact:mecillinamum(synonym)|intact:penicillin HX(synonym)|intact:"6beta-{[(azepan-1-yl)methylidene]amino}-2,2-dimethylpenam-3alpha-carboxylic acid"(iupac name)	psi-mi:penicillin(display_short)|psi-mi:"CHEBI:17334"(display_long)|intact:Penicillin(synonym)|intact:penicillins(synonym)|intact:penicillins(iupac name)	psi-mi:"MI:0051"(fluorescence technology)	Banzhaf et al. (2012)	imex:IM-28369|pubmed:22606933	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26362218|imex:IM-28369-14	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0328"(small molecule)	-	-	-	-	-	figure legend:Fig. 6A|comment:Mecillinam specifically inhibits activity of PBP2.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/07/15	2020/09/30	-	-	-	false	-	bodipy label:?-?	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)