#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q5T0N5-3	uniprotkb:Q8X482	intact:EBI-4403262|ensembl:ENSP00000359275	intact:EBI-22229752|ensemblbacteria:AAG56991	psi-mi:q5t0n5-3(display_long)|uniprotkb:FNBP1L(gene name)|psi-mi:FNBP1L(display_short)|uniprotkb:C1orf39(gene name synonym)|uniprotkb:TOCA1(gene name synonym)|uniprotkb:Transducer of Cdc42-dependent actin assembly protein 1(gene name synonym)	psi-mi:espfu_eco57(display_long)|uniprotkb:EspF-like protein encoded on prophage U(gene name synonym)|uniprotkb:Tir-cytoskeleton coupling protein TccP(gene name synonym)|uniprotkb:"espF(U)"(gene name)|psi-mi:"espF(U)"(display_short)|uniprotkb:tccP(gene name synonym)|uniprotkb:Z3072(locus name)	psi-mi:"MI:0096"(pull down)	Campellone et al. (2012)	pubmed:22544751|imex:IM-27780	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-25468502|imex:IM-27780-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-714058(isoform-parent)|ensembl:ENSG00000137942(gene)|ensembl:ENST00000370253(transcript)	ensemblbacteria:AAG56991(transcript)|ensemblbacteria:Z3072(gene)|go:"GO:0005576"(extracellular region)|go:"GO:0030430"(host cell cytoplasm)|mint:Q8X482|interpro:IPR006891(EspF protein)	-	-	-	figure legend:fig. 6a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/05	2020/03/16	rogid:MpFSdw9824VChZs3SiA7/yrwyGE9606	rogid:5ta4O6gj+U5E7doG3zmjLy36nJ483334	rigid:9SAwwS98Obr5N2at6F/NN4xoKP8	false	green fluorescent protein tag:?-?|mutation disrupting interaction:518-518	his tag:n-n|myc tag:c-c|binding-associated region:134-384	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q5T0N5-3	uniprotkb:Q8X482	intact:EBI-4403262|ensembl:ENSP00000359275	intact:EBI-22229752|ensemblbacteria:AAG56991	psi-mi:q5t0n5-3(display_long)|uniprotkb:FNBP1L(gene name)|psi-mi:FNBP1L(display_short)|uniprotkb:C1orf39(gene name synonym)|uniprotkb:TOCA1(gene name synonym)|uniprotkb:Transducer of Cdc42-dependent actin assembly protein 1(gene name synonym)	psi-mi:espfu_eco57(display_long)|uniprotkb:EspF-like protein encoded on prophage U(gene name synonym)|uniprotkb:Tir-cytoskeleton coupling protein TccP(gene name synonym)|uniprotkb:"espF(U)"(gene name)|psi-mi:"espF(U)"(display_short)|uniprotkb:tccP(gene name synonym)|uniprotkb:Z3072(locus name)	psi-mi:"MI:0047"(far western blotting)	Campellone et al. (2012)	pubmed:22544751|imex:IM-27780	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-25468524|imex:IM-27780-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-714058(isoform-parent)|ensembl:ENSG00000137942(gene)|ensembl:ENST00000370253(transcript)	ensemblbacteria:AAG56991(transcript)|ensemblbacteria:Z3072(gene)|go:"GO:0005576"(extracellular region)|go:"GO:0030430"(host cell cytoplasm)|mint:Q8X482|interpro:IPR006891(EspF protein)	-	-	-	figure legend:fig. 6b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/05	2020/03/11	rogid:MpFSdw9824VChZs3SiA7/yrwyGE9606	rogid:5ta4O6gj+U5E7doG3zmjLy36nJ483334	rigid:9SAwwS98Obr5N2at6F/NN4xoKP8	false	his tag:?-?|mutation disrupting interaction:518-518	myc tag:c-c|binding-associated region:134-384|his tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q5T0N5-3	uniprotkb:Q8X482	intact:EBI-4403262|ensembl:ENSP00000359275	intact:EBI-22229752|ensemblbacteria:AAG56991	psi-mi:q5t0n5-3(display_long)|uniprotkb:FNBP1L(gene name)|psi-mi:FNBP1L(display_short)|uniprotkb:C1orf39(gene name synonym)|uniprotkb:TOCA1(gene name synonym)|uniprotkb:Transducer of Cdc42-dependent actin assembly protein 1(gene name synonym)	psi-mi:espfu_eco57(display_long)|uniprotkb:EspF-like protein encoded on prophage U(gene name synonym)|uniprotkb:Tir-cytoskeleton coupling protein TccP(gene name synonym)|uniprotkb:"espF(U)"(gene name)|psi-mi:"espF(U)"(display_short)|uniprotkb:tccP(gene name synonym)|uniprotkb:Z3072(locus name)	psi-mi:"MI:0018"(two hybrid)	Campellone et al. (2012)	pubmed:22544751|imex:IM-27780	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-25468561|imex:IM-27780-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-714058(isoform-parent)|ensembl:ENSG00000137942(gene)|ensembl:ENST00000370253(transcript)	ensemblbacteria:AAG56991(transcript)|ensemblbacteria:Z3072(gene)|go:"GO:0005576"(extracellular region)|go:"GO:0030430"(host cell cytoplasm)|mint:Q8X482|interpro:IPR006891(EspF protein)	-	-	-	figure legend:fig. 6d|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/03/05	2020/03/11	rogid:MpFSdw9824VChZs3SiA7/yrwyGE9606	rogid:5ta4O6gj+U5E7doG3zmjLy36nJ483334	rigid:9SAwwS98Obr5N2at6F/NN4xoKP8	false	mutation disrupting interaction:518-518|sufficient binding region:481-546	binding-associated region:80-384	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UHR4	uniprotkb:Q8X482	intact:EBI-2483278|ensembl:ENSP00000005260|uniprotkb:A4D268|uniprotkb:Q75L21|uniprotkb:Q75L22|uniprotkb:Q96CV4|uniprotkb:Q9H5F5|uniprotkb:Q9Y2M8	intact:EBI-22229752|ensemblbacteria:AAG56991	psi-mi:bi2l1_human(display_long)|uniprotkb:BAIAP2L1(gene name)|psi-mi:BAIAP2L1(display_short)|uniprotkb:IRTKS(gene name synonym)|uniprotkb:Insulin receptor tyrosine kinase substrate(gene name synonym)	psi-mi:espfu_eco57(display_long)|uniprotkb:EspF-like protein encoded on prophage U(gene name synonym)|uniprotkb:Tir-cytoskeleton coupling protein TccP(gene name synonym)|uniprotkb:"espF(U)"(gene name)|psi-mi:"espF(U)"(display_short)|uniprotkb:tccP(gene name synonym)|uniprotkb:Z3072(locus name)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Campellone et al. (2012)	pubmed:22544751|imex:IM-27780	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-25468605|imex:IM-27780-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000006453(gene)|go:"GO:0003779"(actin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|ensembl:ENST00000005260(transcript)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0009617"(response to bacterium)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051764"(actin crosslink formation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR001452(Src homology-3)|interpro:IPR013606("IRSp53/MIM homology domain (IMD)")|interpro:IPR027267|interpro:IPR027681|interpro:IPR030060|interpro:IPR035592|interpro:IPR036028|rcsb pdb:2KXC|rcsb pdb:2LNH|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9035034|refseq:NP_061330.2|ensembl:ENSP00000005260|dip:DIP-53820N	ensemblbacteria:AAG56991(transcript)|ensemblbacteria:Z3072(gene)|go:"GO:0005576"(extracellular region)|go:"GO:0030430"(host cell cytoplasm)|mint:Q8X482|interpro:IPR006891(EspF protein)	-	-	-	figure legend:fig. 6f|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/05	2020/03/11	rogid:ig7xSOv8h6Y4vYE0/n228+ZLWaM9606	rogid:5ta4O6gj+U5E7doG3zmjLy36nJ483334	rigid:87I9/x/MwMaqS3jWyTZzdBlLmi0	false	glutathione s tranferase tag:?-?|binding-associated region:337-403	biotin tag:?-?|binding-associated region:340-355	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:Q9UQB8	uniprotkb:Q8X482	intact:EBI-525456|uniprotkb:O43858|uniprotkb:Q53HB1|uniprotkb:Q86WC1|uniprotkb:Q8N5C0|uniprotkb:Q96CR7|uniprotkb:Q9UBR3|uniprotkb:Q9UQ43|ensembl:ENSP00000316338	intact:EBI-22229752|ensemblbacteria:AAG56991	psi-mi:baip2_human(display_long)|uniprotkb:Insulin receptor substrate protein of 53 kDa(gene name synonym)|uniprotkb:Insulin receptor substrate p53/p58(gene name synonym)|uniprotkb:Fas ligand-associated factor 3(gene name synonym)|uniprotkb:BAIAP2(gene name)|psi-mi:BAIAP2(display_short)	psi-mi:espfu_eco57(display_long)|uniprotkb:EspF-like protein encoded on prophage U(gene name synonym)|uniprotkb:Tir-cytoskeleton coupling protein TccP(gene name synonym)|uniprotkb:"espF(U)"(gene name)|psi-mi:"espF(U)"(display_short)|uniprotkb:tccP(gene name synonym)|uniprotkb:Z3072(locus name)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Campellone et al. (2012)	pubmed:22544751|imex:IM-27780	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-25468623|imex:IM-27780-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001138360.1|refseq:NP_006331.1|refseq:NP_059344.1|refseq:NP_059345.1|refseq:XP_005257005.1|dip:DIP-29272N|go:"GO:0009617"(response to bacterium)|go:"GO:0016358"(dendrite development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030141"(secretory granule)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030175"(filopodium)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051764"(actin crosslink formation)|go:"GO:0060076"(excitatory synapse)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061845"(neuron projection branch point)|go:"GO:0061846"(dendritic spine cytoplasm)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099564"(modification of synaptic structure, modulating synaptic transmission)|go:"GO:1905232"(cellular response to L-glutamate)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR001452(Src homology-3)|interpro:IPR013606("IRSp53/MIM homology domain (IMD)")|interpro:IPR027267|interpro:IPR027681|interpro:IPR030128|interpro:IPR035594|interpro:IPR036028|mint:Q9UQB8|rcsb pdb:1WDZ|rcsb pdb:1Y2O|rcsb pdb:2YKT|rcsb pdb:3RNJ|rcsb pdb:4JS0|rcsb pdb:6BCR|rcsb pdb:6BCY|rcsb pdb:6BD1|rcsb pdb:6BD2|rcsb pdb:6BQT|rcsb pdb:6ZEG|rcsb pdb:6ZEI|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013423|reactome:R-HSA-9664422|ensembl:ENSG00000175866(gene)|ensembl:ENST00000321300(transcript)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001726"(ruffle)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007409"(axonogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008093"(cytoskeletal anchor activity)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008360"(regulation of cell shape)	ensemblbacteria:AAG56991(transcript)|ensemblbacteria:Z3072(gene)|go:"GO:0005576"(extracellular region)|go:"GO:0030430"(host cell cytoplasm)|mint:Q8X482|interpro:IPR006891(EspF protein)	-	-	-	figure legend:fig. 6f|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/05	2020/03/11	rogid:BRbjAYBnAJN0Pzb7bc/Qtb4w5bY9606	rogid:5ta4O6gj+U5E7doG3zmjLy36nJ483334	rigid:uDBnOUHggDC9kS8o0Std5DXj2lM	false	glutathione s tranferase tag:?-?|binding-associated region:337-403	biotin tag:?-?|binding-associated region:340-355	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)