#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q86WV6	uniprotkb:P0C6X5-PRO_0000283876	intact:EBI-2800345|uniprotkb:A8K3P6|uniprotkb:B6EB35|uniprotkb:D6RBX0|uniprotkb:D6RE01|uniprotkb:D6RID9|ensembl:ENSP00000331288|ensembl:ENSP00000498596|ensembl:ENSP00000499166|ensembl:ENSP00000500685|ensembl:ENSP00000500793|ensembl:ENSP00000500823	intact:EBI-25622115	psi-mi:sting_human(display_long)|uniprotkb:STING1(gene name)|psi-mi:STING1(display_short)|uniprotkb:ERIS(gene name synonym)|uniprotkb:Endoplasmic reticulum interferon stimulator(gene name synonym)|uniprotkb:MITA(gene name synonym)|uniprotkb:Mediator of IRF3 activation(gene name synonym)|uniprotkb:TMEM173(gene name synonym)|uniprotkb:Transmembrane protein 173(gene name synonym)	psi-mi:p0c6x5-pro_0000283876(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sun et al. (2011)	pubmed:22312431|imex:IM-28026	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:277944(cvhnl)|taxid:277944(Human coronavirus NL63)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25622122|imex:IM-28026-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_938023.1|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051607"(defense response to virus)|go:"GO:0061507"(2',3'-cyclic GMP-AMP binding)|go:"GO:0061709"(reticulophagy)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1990701"("integral component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane")|interpro:IPR029158|interpro:IPR033952|interpro:IPR038623|rcsb pdb:4EF4|rcsb pdb:4EF5|rcsb pdb:4EMT|rcsb pdb:4EMU|rcsb pdb:4F5D|rcsb pdb:4F5E|rcsb pdb:4F5W|rcsb pdb:4F5Y|rcsb pdb:4F9E|rcsb pdb:4F9G|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|rcsb pdb:4KSY|rcsb pdb:4LOH|rcsb pdb:4QXO|rcsb pdb:4QXP|rcsb pdb:4QXQ|rcsb pdb:4QXR|rcsb pdb:5BQX|rcsb pdb:5JEJ|rcsb pdb:6CFF|rcsb pdb:6CY7|rcsb pdb:6DNK|rcsb pdb:6DXG|rcsb pdb:6DXL|rcsb pdb:6MX0|rcsb pdb:6MX3|rcsb pdb:6MXE|rcsb pdb:6NT5|rcsb pdb:6O8B|rcsb pdb:6O8C|rcsb pdb:6RM0|rcsb pdb:6S26|rcsb pdb:6S27|rcsb pdb:6S86|rcsb pdb:6UKM|rcsb pdb:6UKU|rcsb pdb:4LOI|rcsb pdb:6UKW|rcsb pdb:6UKX|rcsb pdb:6UKY|rcsb pdb:6UKZ|rcsb pdb:6UL0|rcsb pdb:6XF3|rcsb pdb:6XF4|rcsb pdb:6XNP|rcsb pdb:6Y99|rcsb pdb:6YWA|reactome:R-HSA-1834941|reactome:R-HSA-3134975|reactome:R-HSA-3249367|reactome:R-HSA-3270619|reactome:R-HSA-6798695|rcsb pdb:6UKV|ensembl:ENSG00000184584(gene)|ensembl:ENSG00000288243(gene)|ensembl:ENST00000330794(transcript)|ensembl:ENST00000651699(transcript)|ensembl:ENST00000652271(transcript)|ensembl:ENST00000672096(transcript)|ensembl:ENST00000672102(transcript)|ensembl:ENST00000672865(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0035438"(cyclic-di-GMP binding)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042802"(identical protein binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050727"(regulation of inflammatory response)|dip:DIP-48847N	intact:EBI-25622049(chain-parent)	-	-	chain-seq-start:899|chain-seq-end:2462	figure legend:Figs. 2a, S2|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2020/05/28	2020/05/28	rogid:mNPlnJmpywqUhkyppWMSLmmfOMU9606	rogid:dpvayuSap9rNi2FH0TMR61rN9es277944	rigid:SzvetPKqLXoWRaxvkRApCz/5pfc	false	flag tag:c-c	mutation with no effect:780-780|mutation with no effect:938-938|mutation with no effect:951-951|sufficient binding region:672-1564|v5 tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q86WV6	uniprotkb:Q86WV6	intact:EBI-2800345|uniprotkb:A8K3P6|uniprotkb:B6EB35|uniprotkb:D6RBX0|uniprotkb:D6RE01|uniprotkb:D6RID9|ensembl:ENSP00000331288|ensembl:ENSP00000498596|ensembl:ENSP00000499166|ensembl:ENSP00000500685|ensembl:ENSP00000500793|ensembl:ENSP00000500823	intact:EBI-2800345|uniprotkb:A8K3P6|uniprotkb:B6EB35|uniprotkb:D6RBX0|uniprotkb:D6RE01|uniprotkb:D6RID9|ensembl:ENSP00000331288|ensembl:ENSP00000498596|ensembl:ENSP00000499166|ensembl:ENSP00000500685|ensembl:ENSP00000500793|ensembl:ENSP00000500823	psi-mi:sting_human(display_long)|uniprotkb:STING1(gene name)|psi-mi:STING1(display_short)|uniprotkb:ERIS(gene name synonym)|uniprotkb:Endoplasmic reticulum interferon stimulator(gene name synonym)|uniprotkb:MITA(gene name synonym)|uniprotkb:Mediator of IRF3 activation(gene name synonym)|uniprotkb:TMEM173(gene name synonym)|uniprotkb:Transmembrane protein 173(gene name synonym)	psi-mi:sting_human(display_long)|uniprotkb:STING1(gene name)|psi-mi:STING1(display_short)|uniprotkb:ERIS(gene name synonym)|uniprotkb:Endoplasmic reticulum interferon stimulator(gene name synonym)|uniprotkb:MITA(gene name synonym)|uniprotkb:Mediator of IRF3 activation(gene name synonym)|uniprotkb:TMEM173(gene name synonym)|uniprotkb:Transmembrane protein 173(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sun et al. (2011)	pubmed:22312431|imex:IM-28026	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25622727|imex:IM-28026-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_938023.1|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051607"(defense response to virus)|go:"GO:0061507"(2',3'-cyclic GMP-AMP binding)|go:"GO:0061709"(reticulophagy)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1990701"("integral component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane")|interpro:IPR029158|interpro:IPR033952|interpro:IPR038623|rcsb pdb:4EF4|rcsb pdb:4EF5|rcsb pdb:4EMT|rcsb pdb:4EMU|rcsb pdb:4F5D|rcsb pdb:4F5E|rcsb pdb:4F5W|rcsb pdb:4F5Y|rcsb pdb:4F9E|rcsb pdb:4F9G|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|rcsb pdb:4KSY|rcsb pdb:4LOH|rcsb pdb:4QXO|rcsb pdb:4QXP|rcsb pdb:4QXQ|rcsb pdb:4QXR|rcsb pdb:5BQX|rcsb pdb:5JEJ|rcsb pdb:6CFF|rcsb pdb:6CY7|rcsb pdb:6DNK|rcsb pdb:6DXG|rcsb pdb:6DXL|rcsb pdb:6MX0|rcsb pdb:6MX3|rcsb pdb:6MXE|rcsb pdb:6NT5|rcsb pdb:6O8B|rcsb pdb:6O8C|rcsb pdb:6RM0|rcsb pdb:6S26|rcsb pdb:6S27|rcsb pdb:6S86|rcsb pdb:6UKM|rcsb pdb:6UKU|rcsb pdb:4LOI|rcsb pdb:6UKW|rcsb pdb:6UKX|rcsb pdb:6UKY|rcsb pdb:6UKZ|rcsb pdb:6UL0|rcsb pdb:6XF3|rcsb pdb:6XF4|rcsb pdb:6XNP|rcsb pdb:6Y99|rcsb pdb:6YWA|reactome:R-HSA-1834941|reactome:R-HSA-3134975|reactome:R-HSA-3249367|reactome:R-HSA-3270619|reactome:R-HSA-6798695|rcsb pdb:6UKV|ensembl:ENSG00000184584(gene)|ensembl:ENSG00000288243(gene)|ensembl:ENST00000330794(transcript)|ensembl:ENST00000651699(transcript)|ensembl:ENST00000652271(transcript)|ensembl:ENST00000672096(transcript)|ensembl:ENST00000672102(transcript)|ensembl:ENST00000672865(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0035438"(cyclic-di-GMP binding)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042802"(identical protein binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050727"(regulation of inflammatory response)|dip:DIP-48847N	refseq:NP_938023.1|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051607"(defense response to virus)|go:"GO:0061507"(2',3'-cyclic GMP-AMP binding)|go:"GO:0061709"(reticulophagy)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1990701"("integral component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane")|interpro:IPR029158|interpro:IPR033952|interpro:IPR038623|rcsb pdb:4EF4|rcsb pdb:4EF5|rcsb pdb:4EMT|rcsb pdb:4EMU|rcsb pdb:4F5D|rcsb pdb:4F5E|rcsb pdb:4F5W|rcsb pdb:4F5Y|rcsb pdb:4F9E|rcsb pdb:4F9G|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|rcsb pdb:4KSY|rcsb pdb:4LOH|rcsb pdb:4QXO|rcsb pdb:4QXP|rcsb pdb:4QXQ|rcsb pdb:4QXR|rcsb pdb:5BQX|rcsb pdb:5JEJ|rcsb pdb:6CFF|rcsb pdb:6CY7|rcsb pdb:6DNK|rcsb pdb:6DXG|rcsb pdb:6DXL|rcsb pdb:6MX0|rcsb pdb:6MX3|rcsb pdb:6MXE|rcsb pdb:6NT5|rcsb pdb:6O8B|rcsb pdb:6O8C|rcsb pdb:6RM0|rcsb pdb:6S26|rcsb pdb:6S27|rcsb pdb:6S86|rcsb pdb:6UKM|rcsb pdb:6UKU|rcsb pdb:4LOI|rcsb pdb:6UKW|rcsb pdb:6UKX|rcsb pdb:6UKY|rcsb pdb:6UKZ|rcsb pdb:6UL0|rcsb pdb:6XF3|rcsb pdb:6XF4|rcsb pdb:6XNP|rcsb pdb:6Y99|rcsb pdb:6YWA|reactome:R-HSA-1834941|reactome:R-HSA-3134975|reactome:R-HSA-3249367|reactome:R-HSA-3270619|reactome:R-HSA-6798695|rcsb pdb:6UKV|ensembl:ENSG00000184584(gene)|ensembl:ENSG00000288243(gene)|ensembl:ENST00000330794(transcript)|ensembl:ENST00000651699(transcript)|ensembl:ENST00000652271(transcript)|ensembl:ENST00000672096(transcript)|ensembl:ENST00000672102(transcript)|ensembl:ENST00000672865(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0035438"(cyclic-di-GMP binding)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042802"(identical protein binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050727"(regulation of inflammatory response)|dip:DIP-48847N	-	-	-	figure legend:Fig. 3c|comment:"A reduction in STING dimers was detected in cells expressing wt PLP2-TM and the D1849A mutant which retains deubiquitinating (DUB) activity, but not in cells expressing the  C1678A or H1836A mutants which do not possess DUB activity"|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2020/05/28	2020/05/28	rogid:mNPlnJmpywqUhkyppWMSLmmfOMU9606	rogid:mNPlnJmpywqUhkyppWMSLmmfOMU9606	rigid:+mlOKqwlhB6E8y9QKfvh9CE/7U4	false	flag tag:c-c	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O95786	uniprotkb:Q86WV6	intact:EBI-995350|uniprotkb:Q5HYE1|uniprotkb:Q5VYT1|uniprotkb:Q9NT04|uniprotkb:A2RU81|ensembl:ENSP00000369213	intact:EBI-2800345|uniprotkb:A8K3P6|uniprotkb:B6EB35|uniprotkb:D6RBX0|uniprotkb:D6RE01|uniprotkb:D6RID9|ensembl:ENSP00000331288|ensembl:ENSP00000498596|ensembl:ENSP00000499166|ensembl:ENSP00000500685|ensembl:ENSP00000500793|ensembl:ENSP00000500823	psi-mi:ddx58_human(display_long)|uniprotkb:DEAD box protein 58(gene name synonym)|uniprotkb:Retinoic acid-inducible gene 1 protein(gene name synonym)|uniprotkb:DDX58(gene name)|psi-mi:DDX58(display_short)|uniprotkb:Probable ATP-dependent RNA helicase DDX58(gene name synonym)|uniprotkb:Retinoic acid-inducible gene I protein(gene name synonym)|uniprotkb:RIG-I-like receptor 1(gene name synonym)	psi-mi:sting_human(display_long)|uniprotkb:STING1(gene name)|psi-mi:STING1(display_short)|uniprotkb:ERIS(gene name synonym)|uniprotkb:Endoplasmic reticulum interferon stimulator(gene name synonym)|uniprotkb:MITA(gene name synonym)|uniprotkb:Mediator of IRF3 activation(gene name synonym)|uniprotkb:TMEM173(gene name synonym)|uniprotkb:Transmembrane protein 173(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sun et al. (2011)	pubmed:22312431|imex:IM-28026	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25622861|imex:IM-28026-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034344"(regulation of type III interferon production)|go:"GO:0032587"(ruffle membrane)|go:"GO:0039528"(cytoplasmic pattern recognition receptor signaling pathway in response to virus)|go:"GO:0039529"(RIG-I signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|ensembl:ENSG00000107201(gene)|ensembl:ENST00000379883(transcript)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002735"(positive regulation of myeloid dendritic cell cytokine production)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009597"(detection of virus)|go:"GO:0009615"(response to virus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011029(DEATH-like)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR021673|interpro:IPR027417|interpro:IPR031964|interpro:IPR038557|interpro:IPR041204|interpro:IPR042145|mint:O95786|rcsb pdb:2LWD|rcsb pdb:2LWE|rcsb pdb:2QFB|rcsb pdb:2QFD|rcsb pdb:2RMJ|rcsb pdb:2YKG|rcsb pdb:3LRN|rcsb pdb:3LRR|rcsb pdb:3NCU|rcsb pdb:3OG8|rcsb pdb:3ZD6|rcsb pdb:3ZD7|rcsb pdb:4AY2|rcsb pdb:4BPB|rcsb pdb:4NQK|rcsb pdb:4ON9|rcsb pdb:4P4H|rcsb pdb:5E3H|rcsb pdb:5F98|rcsb pdb:5F9F|rcsb pdb:5F9H|rcsb pdb:6GPG|rcsb pdb:6KYV|rcsb pdb:7JL1|rcsb pdb:7JL3|reactome:R-HSA-1169408|reactome:R-HSA-168928|go:"GO:0071360"(cellular response to exogenous dsRNA)|reactome:R-HSA-5689880|reactome:R-HSA-5689896|go:"GO:0051607"(defense response to virus)|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-936440|reactome:R-HSA-8983711|refseq:NP_055129.2|dip:DIP-35444N	refseq:NP_938023.1|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051607"(defense response to virus)|go:"GO:0061507"(2',3'-cyclic GMP-AMP binding)|go:"GO:0061709"(reticulophagy)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1990701"("integral component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane")|interpro:IPR029158|interpro:IPR033952|interpro:IPR038623|rcsb pdb:4EF4|rcsb pdb:4EF5|rcsb pdb:4EMT|rcsb pdb:4EMU|rcsb pdb:4F5D|rcsb pdb:4F5E|rcsb pdb:4F5W|rcsb pdb:4F5Y|rcsb pdb:4F9E|rcsb pdb:4F9G|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|rcsb pdb:4KSY|rcsb pdb:4LOH|rcsb pdb:4QXO|rcsb pdb:4QXP|rcsb pdb:4QXQ|rcsb pdb:4QXR|rcsb pdb:5BQX|rcsb pdb:5JEJ|rcsb pdb:6CFF|rcsb pdb:6CY7|rcsb pdb:6DNK|rcsb pdb:6DXG|rcsb pdb:6DXL|rcsb pdb:6MX0|rcsb pdb:6MX3|rcsb pdb:6MXE|rcsb pdb:6NT5|rcsb pdb:6O8B|rcsb pdb:6O8C|rcsb pdb:6RM0|rcsb pdb:6S26|rcsb pdb:6S27|rcsb pdb:6S86|rcsb pdb:6UKM|rcsb pdb:6UKU|rcsb pdb:4LOI|rcsb pdb:6UKW|rcsb pdb:6UKX|rcsb pdb:6UKY|rcsb pdb:6UKZ|rcsb pdb:6UL0|rcsb pdb:6XF3|rcsb pdb:6XF4|rcsb pdb:6XNP|rcsb pdb:6Y99|rcsb pdb:6YWA|reactome:R-HSA-1834941|reactome:R-HSA-3134975|reactome:R-HSA-3249367|reactome:R-HSA-3270619|reactome:R-HSA-6798695|rcsb pdb:6UKV|ensembl:ENSG00000184584(gene)|ensembl:ENSG00000288243(gene)|ensembl:ENST00000330794(transcript)|ensembl:ENST00000651699(transcript)|ensembl:ENST00000652271(transcript)|ensembl:ENST00000672096(transcript)|ensembl:ENST00000672102(transcript)|ensembl:ENST00000672865(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0035438"(cyclic-di-GMP binding)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042802"(identical protein binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050727"(regulation of inflammatory response)|dip:DIP-48847N	-	-	-	figure legend:Fig. 4a|comment:Expression of PLP2-TM had no effect on co-immunoprecipitation of RIG-I with STING|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2020/05/28	2020/05/28	rogid:nAw8D8xPo46hNj9gg2hjFeA5Mtc9606	rogid:mNPlnJmpywqUhkyppWMSLmmfOMU9606	rigid:Siix7UKnX1hknAQki16gDg2g6pA	false	flag tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q7Z434	uniprotkb:Q86WV6	intact:EBI-995373|uniprotkb:Q3I0Y2|uniprotkb:Q5T7I6|uniprotkb:Q86VY7|uniprotkb:Q9H1H3|uniprotkb:Q9H4Y1|uniprotkb:Q9H8D3|uniprotkb:Q9ULE9|uniprotkb:Q2HWT5|ensembl:ENSP00000401980|uniprotkb:M1P2Z0|uniprotkb:A8K6X0|uniprotkb:F5H6C8|uniprotkb:B2BD33|uniprotkb:B2BD34	intact:EBI-2800345|uniprotkb:A8K3P6|uniprotkb:B6EB35|uniprotkb:D6RBX0|uniprotkb:D6RE01|uniprotkb:D6RID9|ensembl:ENSP00000331288|ensembl:ENSP00000498596|ensembl:ENSP00000499166|ensembl:ENSP00000500685|ensembl:ENSP00000500793|ensembl:ENSP00000500823	psi-mi:mavs_human(display_long)|uniprotkb:Interferon beta promoter stimulator protein 1(gene name synonym)|uniprotkb:Virus-induced-signaling adapter(gene name synonym)|uniprotkb:CARD adapter inducing interferon beta(gene name synonym)|uniprotkb:Putative NF-kappa-B-activating protein 031N(gene name synonym)|uniprotkb:MAVS(gene name)|psi-mi:MAVS(display_short)|uniprotkb:IPS1(gene name synonym)|uniprotkb:KIAA1271(gene name synonym)|uniprotkb:VISA(gene name synonym)	psi-mi:sting_human(display_long)|uniprotkb:STING1(gene name)|psi-mi:STING1(display_short)|uniprotkb:ERIS(gene name synonym)|uniprotkb:Endoplasmic reticulum interferon stimulator(gene name synonym)|uniprotkb:MITA(gene name synonym)|uniprotkb:Mediator of IRF3 activation(gene name synonym)|uniprotkb:TMEM173(gene name synonym)|uniprotkb:Transmembrane protein 173(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sun et al. (2011)	pubmed:22312431|imex:IM-28026	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25622915|imex:IM-28026-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001193420.1|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050700"(CARD domain binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|ensembl:ENSG00000088888(gene)|ensembl:ENST00000428216(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002735"(positive regulation of myeloid dendritic cell cytokine production)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071651"("positive regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0071660"(positive regulation of IP-10 production)|go:"GO:1900063"(regulation of peroxisome organization)|interpro:IPR011029(DEATH-like)|interpro:IPR026148|interpro:IPR031964|interpro:IPR042144|mint:Q7Z434|rcsb pdb:2MS7|rcsb pdb:2MS8|rcsb pdb:2VGQ|rcsb pdb:3J6C|rcsb pdb:3J6J|rcsb pdb:3RC5|rcsb pdb:4P4H|rcsb pdb:4Z8M|rcsb pdb:5JEK|reactome:R-HSA-168928|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-936440|reactome:R-HSA-5689896|refseq:NP_065797.2|dip:DIP-35445N	refseq:NP_938023.1|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051607"(defense response to virus)|go:"GO:0061507"(2',3'-cyclic GMP-AMP binding)|go:"GO:0061709"(reticulophagy)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1990701"("integral component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane")|interpro:IPR029158|interpro:IPR033952|interpro:IPR038623|rcsb pdb:4EF4|rcsb pdb:4EF5|rcsb pdb:4EMT|rcsb pdb:4EMU|rcsb pdb:4F5D|rcsb pdb:4F5E|rcsb pdb:4F5W|rcsb pdb:4F5Y|rcsb pdb:4F9E|rcsb pdb:4F9G|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|rcsb pdb:4KSY|rcsb pdb:4LOH|rcsb pdb:4QXO|rcsb pdb:4QXP|rcsb pdb:4QXQ|rcsb pdb:4QXR|rcsb pdb:5BQX|rcsb pdb:5JEJ|rcsb pdb:6CFF|rcsb pdb:6CY7|rcsb pdb:6DNK|rcsb pdb:6DXG|rcsb pdb:6DXL|rcsb pdb:6MX0|rcsb pdb:6MX3|rcsb pdb:6MXE|rcsb pdb:6NT5|rcsb pdb:6O8B|rcsb pdb:6O8C|rcsb pdb:6RM0|rcsb pdb:6S26|rcsb pdb:6S27|rcsb pdb:6S86|rcsb pdb:6UKM|rcsb pdb:6UKU|rcsb pdb:4LOI|rcsb pdb:6UKW|rcsb pdb:6UKX|rcsb pdb:6UKY|rcsb pdb:6UKZ|rcsb pdb:6UL0|rcsb pdb:6XF3|rcsb pdb:6XF4|rcsb pdb:6XNP|rcsb pdb:6Y99|rcsb pdb:6YWA|reactome:R-HSA-1834941|reactome:R-HSA-3134975|reactome:R-HSA-3249367|reactome:R-HSA-3270619|reactome:R-HSA-6798695|rcsb pdb:6UKV|ensembl:ENSG00000184584(gene)|ensembl:ENSG00000288243(gene)|ensembl:ENST00000330794(transcript)|ensembl:ENST00000651699(transcript)|ensembl:ENST00000652271(transcript)|ensembl:ENST00000672096(transcript)|ensembl:ENST00000672102(transcript)|ensembl:ENST00000672865(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0035438"(cyclic-di-GMP binding)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042802"(identical protein binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050727"(regulation of inflammatory response)|dip:DIP-48847N	-	-	-	figure legend:Fig. 4b|comment:Co-immunoprecipitation of MAVS was disrupted by expression of PLP2-TM|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2020/05/28	2020/05/28	rogid:NUZJ/I/rKEG17NeqQS067haIDhY9606	rogid:mNPlnJmpywqUhkyppWMSLmmfOMU9606	rigid:CDRk7atfKKZg4F/5mVK7/Ndybzg	false	flag tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q86WV6	uniprotkb:P0C6X5-PRO_0000283876	intact:EBI-2800345|uniprotkb:A8K3P6|uniprotkb:B6EB35|uniprotkb:D6RBX0|uniprotkb:D6RE01|uniprotkb:D6RID9|ensembl:ENSP00000331288|ensembl:ENSP00000498596|ensembl:ENSP00000499166|ensembl:ENSP00000500685|ensembl:ENSP00000500793|ensembl:ENSP00000500823	intact:EBI-25622115	psi-mi:sting_human(display_long)|uniprotkb:STING1(gene name)|psi-mi:STING1(display_short)|uniprotkb:ERIS(gene name synonym)|uniprotkb:Endoplasmic reticulum interferon stimulator(gene name synonym)|uniprotkb:MITA(gene name synonym)|uniprotkb:Mediator of IRF3 activation(gene name synonym)|uniprotkb:TMEM173(gene name synonym)|uniprotkb:Transmembrane protein 173(gene name synonym)	psi-mi:p0c6x5-pro_0000283876(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sun et al. (2011)	pubmed:22312431|imex:IM-28026	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:277944(cvhnl)|taxid:277944(Human coronavirus NL63)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25645851|imex:IM-28026-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_938023.1|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051607"(defense response to virus)|go:"GO:0061507"(2',3'-cyclic GMP-AMP binding)|go:"GO:0061709"(reticulophagy)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1990701"("integral component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane")|interpro:IPR029158|interpro:IPR033952|interpro:IPR038623|rcsb pdb:4EF4|rcsb pdb:4EF5|rcsb pdb:4EMT|rcsb pdb:4EMU|rcsb pdb:4F5D|rcsb pdb:4F5E|rcsb pdb:4F5W|rcsb pdb:4F5Y|rcsb pdb:4F9E|rcsb pdb:4F9G|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|rcsb pdb:4KSY|rcsb pdb:4LOH|rcsb pdb:4QXO|rcsb pdb:4QXP|rcsb pdb:4QXQ|rcsb pdb:4QXR|rcsb pdb:5BQX|rcsb pdb:5JEJ|rcsb pdb:6CFF|rcsb pdb:6CY7|rcsb pdb:6DNK|rcsb pdb:6DXG|rcsb pdb:6DXL|rcsb pdb:6MX0|rcsb pdb:6MX3|rcsb pdb:6MXE|rcsb pdb:6NT5|rcsb pdb:6O8B|rcsb pdb:6O8C|rcsb pdb:6RM0|rcsb pdb:6S26|rcsb pdb:6S27|rcsb pdb:6S86|rcsb pdb:6UKM|rcsb pdb:6UKU|rcsb pdb:4LOI|rcsb pdb:6UKW|rcsb pdb:6UKX|rcsb pdb:6UKY|rcsb pdb:6UKZ|rcsb pdb:6UL0|rcsb pdb:6XF3|rcsb pdb:6XF4|rcsb pdb:6XNP|rcsb pdb:6Y99|rcsb pdb:6YWA|reactome:R-HSA-1834941|reactome:R-HSA-3134975|reactome:R-HSA-3249367|reactome:R-HSA-3270619|reactome:R-HSA-6798695|rcsb pdb:6UKV|ensembl:ENSG00000184584(gene)|ensembl:ENSG00000288243(gene)|ensembl:ENST00000330794(transcript)|ensembl:ENST00000651699(transcript)|ensembl:ENST00000652271(transcript)|ensembl:ENST00000672096(transcript)|ensembl:ENST00000672102(transcript)|ensembl:ENST00000672865(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0035438"(cyclic-di-GMP binding)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042802"(identical protein binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050727"(regulation of inflammatory response)|dip:DIP-48847N	intact:EBI-25622049(chain-parent)	-	-	chain-seq-start:899|chain-seq-end:2462	figure legend:Fig. S3|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2020/05/28	2020/06/15	rogid:mNPlnJmpywqUhkyppWMSLmmfOMU9606	rogid:dpvayuSap9rNi2FH0TMR61rN9es277944	rigid:SzvetPKqLXoWRaxvkRApCz/5pfc	false	ha tag:?-?	mutation decreasing interaction strength:780-780|sufficient binding region:672-1564|v5 tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q86WV6	uniprotkb:P0C6X5-PRO_0000283876	intact:EBI-2800345|uniprotkb:A8K3P6|uniprotkb:B6EB35|uniprotkb:D6RBX0|uniprotkb:D6RE01|uniprotkb:D6RID9|ensembl:ENSP00000331288|ensembl:ENSP00000498596|ensembl:ENSP00000499166|ensembl:ENSP00000500685|ensembl:ENSP00000500793|ensembl:ENSP00000500823	intact:EBI-25622115	psi-mi:sting_human(display_long)|uniprotkb:STING1(gene name)|psi-mi:STING1(display_short)|uniprotkb:ERIS(gene name synonym)|uniprotkb:Endoplasmic reticulum interferon stimulator(gene name synonym)|uniprotkb:MITA(gene name synonym)|uniprotkb:Mediator of IRF3 activation(gene name synonym)|uniprotkb:TMEM173(gene name synonym)|uniprotkb:Transmembrane protein 173(gene name synonym)	psi-mi:p0c6x5-pro_0000283876(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0663"(confocal microscopy)	Sun et al. (2011)	pubmed:22312431|imex:IM-28026	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:277944(cvhnl)|taxid:277944(Human coronavirus NL63)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25622611|imex:IM-28026-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_938023.1|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051607"(defense response to virus)|go:"GO:0061507"(2',3'-cyclic GMP-AMP binding)|go:"GO:0061709"(reticulophagy)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1990701"("integral component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane")|interpro:IPR029158|interpro:IPR033952|interpro:IPR038623|rcsb pdb:4EF4|rcsb pdb:4EF5|rcsb pdb:4EMT|rcsb pdb:4EMU|rcsb pdb:4F5D|rcsb pdb:4F5E|rcsb pdb:4F5W|rcsb pdb:4F5Y|rcsb pdb:4F9E|rcsb pdb:4F9G|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|rcsb pdb:4KSY|rcsb pdb:4LOH|rcsb pdb:4QXO|rcsb pdb:4QXP|rcsb pdb:4QXQ|rcsb pdb:4QXR|rcsb pdb:5BQX|rcsb pdb:5JEJ|rcsb pdb:6CFF|rcsb pdb:6CY7|rcsb pdb:6DNK|rcsb pdb:6DXG|rcsb pdb:6DXL|rcsb pdb:6MX0|rcsb pdb:6MX3|rcsb pdb:6MXE|rcsb pdb:6NT5|rcsb pdb:6O8B|rcsb pdb:6O8C|rcsb pdb:6RM0|rcsb pdb:6S26|rcsb pdb:6S27|rcsb pdb:6S86|rcsb pdb:6UKM|rcsb pdb:6UKU|rcsb pdb:4LOI|rcsb pdb:6UKW|rcsb pdb:6UKX|rcsb pdb:6UKY|rcsb pdb:6UKZ|rcsb pdb:6UL0|rcsb pdb:6XF3|rcsb pdb:6XF4|rcsb pdb:6XNP|rcsb pdb:6Y99|rcsb pdb:6YWA|reactome:R-HSA-1834941|reactome:R-HSA-3134975|reactome:R-HSA-3249367|reactome:R-HSA-3270619|reactome:R-HSA-6798695|rcsb pdb:6UKV|ensembl:ENSG00000184584(gene)|ensembl:ENSG00000288243(gene)|ensembl:ENST00000330794(transcript)|ensembl:ENST00000651699(transcript)|ensembl:ENST00000652271(transcript)|ensembl:ENST00000672096(transcript)|ensembl:ENST00000672102(transcript)|ensembl:ENST00000672865(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0035438"(cyclic-di-GMP binding)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042802"(identical protein binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050727"(regulation of inflammatory response)|dip:DIP-48847N	intact:EBI-25622049(chain-parent)	go:"GO:0005737"(cytoplasm)	-	chain-seq-start:899|chain-seq-end:2462	figure legend:Fig. 1d|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2020/05/28	2020/05/28	rogid:mNPlnJmpywqUhkyppWMSLmmfOMU9606	rogid:dpvayuSap9rNi2FH0TMR61rN9es277944	rigid:SzvetPKqLXoWRaxvkRApCz/5pfc	false	ha tag:?-?	sufficient binding region:672-1564|v5 tag:c-c	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q86WV6	uniprotkb:P0C6X5-PRO_0000283876	intact:EBI-2800345|uniprotkb:A8K3P6|uniprotkb:B6EB35|uniprotkb:D6RBX0|uniprotkb:D6RE01|uniprotkb:D6RID9|ensembl:ENSP00000331288|ensembl:ENSP00000498596|ensembl:ENSP00000499166|ensembl:ENSP00000500685|ensembl:ENSP00000500793|ensembl:ENSP00000500823	intact:EBI-25622115	psi-mi:sting_human(display_long)|uniprotkb:STING1(gene name)|psi-mi:STING1(display_short)|uniprotkb:ERIS(gene name synonym)|uniprotkb:Endoplasmic reticulum interferon stimulator(gene name synonym)|uniprotkb:MITA(gene name synonym)|uniprotkb:Mediator of IRF3 activation(gene name synonym)|uniprotkb:TMEM173(gene name synonym)|uniprotkb:Transmembrane protein 173(gene name synonym)	psi-mi:p0c6x5-pro_0000283876(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0663"(confocal microscopy)	Sun et al. (2011)	pubmed:22312431|imex:IM-28026	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:277944(cvhnl)|taxid:277944(Human coronavirus NL63)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25622647|imex:IM-28026-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_938023.1|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051607"(defense response to virus)|go:"GO:0061507"(2',3'-cyclic GMP-AMP binding)|go:"GO:0061709"(reticulophagy)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1990701"("integral component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane")|interpro:IPR029158|interpro:IPR033952|interpro:IPR038623|rcsb pdb:4EF4|rcsb pdb:4EF5|rcsb pdb:4EMT|rcsb pdb:4EMU|rcsb pdb:4F5D|rcsb pdb:4F5E|rcsb pdb:4F5W|rcsb pdb:4F5Y|rcsb pdb:4F9E|rcsb pdb:4F9G|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|rcsb pdb:4KSY|rcsb pdb:4LOH|rcsb pdb:4QXO|rcsb pdb:4QXP|rcsb pdb:4QXQ|rcsb pdb:4QXR|rcsb pdb:5BQX|rcsb pdb:5JEJ|rcsb pdb:6CFF|rcsb pdb:6CY7|rcsb pdb:6DNK|rcsb pdb:6DXG|rcsb pdb:6DXL|rcsb pdb:6MX0|rcsb pdb:6MX3|rcsb pdb:6MXE|rcsb pdb:6NT5|rcsb pdb:6O8B|rcsb pdb:6O8C|rcsb pdb:6RM0|rcsb pdb:6S26|rcsb pdb:6S27|rcsb pdb:6S86|rcsb pdb:6UKM|rcsb pdb:6UKU|rcsb pdb:4LOI|rcsb pdb:6UKW|rcsb pdb:6UKX|rcsb pdb:6UKY|rcsb pdb:6UKZ|rcsb pdb:6UL0|rcsb pdb:6XF3|rcsb pdb:6XF4|rcsb pdb:6XNP|rcsb pdb:6Y99|rcsb pdb:6YWA|reactome:R-HSA-1834941|reactome:R-HSA-3134975|reactome:R-HSA-3249367|reactome:R-HSA-3270619|reactome:R-HSA-6798695|rcsb pdb:6UKV|ensembl:ENSG00000184584(gene)|ensembl:ENSG00000288243(gene)|ensembl:ENST00000330794(transcript)|ensembl:ENST00000651699(transcript)|ensembl:ENST00000652271(transcript)|ensembl:ENST00000672096(transcript)|ensembl:ENST00000672102(transcript)|ensembl:ENST00000672865(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0035438"(cyclic-di-GMP binding)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042802"(identical protein binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050727"(regulation of inflammatory response)|dip:DIP-48847N	intact:EBI-25622049(chain-parent)	-	-	chain-seq-start:899|chain-seq-end:2462	figure legend:Fig. 2b|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2020/05/28	2020/05/28	rogid:mNPlnJmpywqUhkyppWMSLmmfOMU9606	rogid:dpvayuSap9rNi2FH0TMR61rN9es277944	rigid:SzvetPKqLXoWRaxvkRApCz/5pfc	false	v5 tag:?-?	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)