#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P0C6X7-PRO_0000037309 uniprotkb:P62937 intact:EBI-25475797 intact:EBI-437708|uniprotkb:P05092|uniprotkb:Q3KQW3|uniprotkb:Q6IBU5|uniprotkb:Q96IX3|uniprotkb:Q9BRU4|uniprotkb:Q9BTY9|uniprotkb:Q9UC61|uniprotkb:Q567Q0|ensembl:ENSP00000419425|uniprotkb:A8K220 psi-mi:p0c6x7-pro_0000037309(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:ppia_human(display_long)|uniprotkb:Cyclophilin A(gene name synonym)|uniprotkb:Cyclosporin A-binding protein(gene name synonym)|uniprotkb:PPIA(gene name)|psi-mi:PPIA(display_short)|uniprotkb:CYPA(gene name synonym)|uniprotkb:Rotamase A(gene name synonym) psi-mi:"MI:0398"(two hybrid pooling approach) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25488476|imex:IM-27830-18 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7843867(chain-parent)|uniprotkb:P0C6X7(chain-parent) refseq:NP_066953.1|interpro:IPR029000|mint:P62937|rcsb pdb:1AK4|rcsb pdb:1AWQ|rcsb pdb:1AWR|rcsb pdb:1AWS|rcsb pdb:1AWT|rcsb pdb:1AWU|rcsb pdb:1AWV|rcsb pdb:1BCK|rcsb pdb:1CWA|rcsb pdb:1CWB|rcsb pdb:1CWC|rcsb pdb:1CWF|rcsb pdb:1CWH|rcsb pdb:1CWI|rcsb pdb:1CWJ|rcsb pdb:1CWK|rcsb pdb:1CWL|rcsb pdb:1CWM|interpro:IPR024936|rcsb pdb:1CWO|rcsb pdb:1FGL|rcsb pdb:2N0T|rcsb pdb:2RMA|rcsb pdb:1M63|rcsb pdb:2RMB|rcsb pdb:2X25|rcsb pdb:2X2A|rcsb pdb:2X2C|rcsb pdb:2X2D|rcsb pdb:1M9C|rcsb pdb:1M9D|rcsb pdb:1M9E|rcsb pdb:2XGY|rcsb pdb:3CYH|rcsb pdb:3CYS|rcsb pdb:3K0M|rcsb pdb:3K0N|rcsb pdb:3K0O|rcsb pdb:3K0P|rcsb pdb:3K0Q|rcsb pdb:3K0R|rcsb pdb:3ODI|rcsb pdb:3ODL|rcsb pdb:1M9F|rcsb pdb:3RDD|rcsb pdb:1M9X|rcsb pdb:1M9Y|rcsb pdb:4CYH|rcsb pdb:4IPZ|rcsb pdb:4N1M|rcsb pdb:4N1N|rcsb pdb:1MF8|rcsb pdb:4N1O|rcsb pdb:4N1P|rcsb pdb:4N1Q|rcsb pdb:1MIK|rcsb pdb:1NMK|rcsb pdb:1OCA|rcsb pdb:1RMH|rcsb pdb:1VBS|rcsb pdb:1VBT|rcsb pdb:1W8L|rcsb pdb:1W8M|rcsb pdb:1W8V|rcsb pdb:1YND|rcsb pdb:1ZKF|rcsb pdb:2ALF|rcsb pdb:2CPL|rcsb pdb:2CYH|rcsb pdb:2MS4|rcsb pdb:2MZU|rcsb pdb:4N1R|rcsb pdb:4N1S|rcsb pdb:4YUG|rcsb pdb:4YUH|refseq:NP_001287910.1|reactome:R-HSA-210991|reactome:R-HSA-6798695|reactome:R-HSA-8950505|reactome:R-HSA-2025928|ensembl:ENSG00000196262(gene)|ensembl:ENST00000468812(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006457"(protein folding)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006915"(apoptotic process)|go:"GO:0016018"(cyclosporin A binding)|go:"GO:0016020"(membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0030168"(platelet activation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031982"(vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032873"(negative regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034389"(lipid droplet organization)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045069"(regulation of viral genome replication)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046790"(virion binding)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060352"(cell adhesion molecule production)|go:"GO:0061944"(negative regulation of protein K48-linked ubiquitination)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903901"(negative regulation of viral life cycle)|go:"GO:1904399"(heparan sulfate binding)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2001233"(regulation of apoptotic signaling pathway)|interpro:IPR002130(Peptidyl-prolyl cis-trans isomerase, cyclophilin-type)|interpro:IPR020892|go:"GO:0005178"(integrin binding)|rcsb pdb:4YUI|rcsb pdb:4YUJ|rcsb pdb:4YUK|rcsb pdb:4YUL|rcsb pdb:4YUM|rcsb pdb:4YUN|rcsb pdb:4YUO|rcsb pdb:4YUP|rcsb pdb:5CYH|rcsb pdb:5F66|rcsb pdb:5FJB|rcsb pdb:5KUL|rcsb pdb:5KUN|rcsb pdb:5KUO|rcsb pdb:5KUQ|rcsb pdb:5KUR|rcsb pdb:5KUS|rcsb pdb:5KUU|rcsb pdb:5KUV|rcsb pdb:5KUW|rcsb pdb:5KUZ|rcsb pdb:5KV0|rcsb pdb:5KV1|rcsb pdb:5KV2|rcsb pdb:5KV3|rcsb pdb:5KV4|rcsb pdb:5KV5|rcsb pdb:5KV6|rcsb pdb:5KV7|rcsb pdb:5LUD|rcsb pdb:5NOQ|rcsb pdb:5NOR|rcsb pdb:5NOT|rcsb pdb:5NOU|rcsb pdb:5NOV|rcsb pdb:5NOW|rcsb pdb:5NOX|rcsb pdb:5NOY|rcsb pdb:5NOZ|rcsb pdb:5T9U|rcsb pdb:5T9W|rcsb pdb:5T9Z|rcsb pdb:5TA2|rcsb pdb:5TA4|rcsb pdb:5WC7|rcsb pdb:6BTA|rcsb pdb:6GJI|rcsb pdb:6GJJ|rcsb pdb:6GJL|rcsb pdb:6GJM|rcsb pdb:6GJN|rcsb pdb:6GJP|rcsb pdb:6GJR|rcsb pdb:6GJY|rcsb pdb:6GS6|rcsb pdb:6I42|rcsb pdb:6U5C|rcsb pdb:6U5D|rcsb pdb:6U5E|rcsb pdb:6U5G|rcsb pdb:6X3R|rcsb pdb:6X3Y|rcsb pdb:5NOS|rcsb pdb:6X4N|rcsb pdb:6X4O|rcsb pdb:6X4P|rcsb pdb:6X4Q|rcsb pdb:6Y9V|rcsb pdb:6Y9W|rcsb pdb:6Y9X|rcsb pdb:6Y9Y|rcsb pdb:6Y9Z|rcsb pdb:6ZDJ|rcsb pdb:7ABT|reactome:R-HSA-114608|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-173107|rcsb pdb:6X4M|reactome:R-HSA-175474|reactome:R-HSA-180689|dip:DIP-6080N - chain-seq-start:1|chain-seq-end:180 - figure legend:ST1|comment:"Library for Y2H screening used: fetal brain"|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/19 2020/03/31 rogid:qbwEpGmE3J035KnL6QbEZ/HRJAw694009 rogid:dr4EVxcO+sqTPBqsQcydRn+rHoo9606 rigid:XX/pCBj3HQy8hQeRejP0dbpwzRQ false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P0C6X7-PRO_0000037309 uniprotkb:Q9UQN3 intact:EBI-25475797 intact:EBI-718324|uniprotkb:Q53HC7|uniprotkb:Q9Y4U6|intact:EBI-11161391|uniprotkb:B4DJG8|ensembl:ENSP00000263780 psi-mi:p0c6x7-pro_0000037309(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:chm2b_human(display_long)|uniprotkb:Chromatin-modifying protein 2b(gene name synonym)|uniprotkb:CHMP2.5(gene name synonym)|uniprotkb:Vacuolar protein sorting-associated protein 2-2(gene name synonym)|uniprotkb:CHMP2B(gene name)|psi-mi:CHMP2B(display_short)|uniprotkb:CGI-84(orf name) psi-mi:"MI:0398"(two hybrid pooling approach) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25488518|imex:IM-27830-98 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7843867(chain-parent)|uniprotkb:P0C6X7(chain-parent) refseq:NP_054762.2|refseq:NP_001231573.1|ensembl:ENSG00000083937(gene)|ensembl:ENST00000263780(transcript)|go:"GO:0000815"(ESCRT III complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005771"(multivesicular body)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0006997"(nucleus organization)|go:"GO:0007032"(endosome organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016236"(macroautophagy)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032509"(endosome transport via multivesicular body sorting pathway)|go:"GO:0036258"(multivesicular body assembly)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0045296"(cadherin binding)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0050890"(cognition)|go:"GO:0061763"(multivesicular body-lysosome fusion)|go:"GO:0061952"(midbody abscission)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099159"(regulation of modification of postsynaptic structure)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:1901673"(regulation of mitotic spindle assembly)|go:"GO:1902188"(obsolete positive regulation of viral release from host cell)|go:"GO:1904903"(ESCRT III complex disassembly)|interpro:IPR005024(Snf7)|mint:Q9UQN3|rcsb pdb:2JQK|reactome:R-HSA-162588|reactome:R-HSA-1632852|reactome:R-HSA-5620971|reactome:R-HSA-917729|reactome:R-HSA-9610379|reactome:R-HSA-9615710|reactome:R-HSA-9668328|reactome:R-HSA-9679504|reactome:R-HSA-9694676|go:"GO:0010824"(regulation of centrosome duplication)|dip:DIP-50766N - chain-seq-start:1|chain-seq-end:180 - figure legend:ST1|comment:"Library for Y2H screening used: ORFeome, brain"|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/19 2020/03/31 rogid:qbwEpGmE3J035KnL6QbEZ/HRJAw694009 rogid:WmtZzxKkbkLsgFov/DJDKKGvIto9606 rigid:CR1K2vGrwYOoh3MmO4hyX6M9yCs false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P0C6X7-PRO_0000037318 uniprotkb:Q5SQN1 intact:EBI-25487684 intact:EBI-10244848|uniprotkb:Q8TB31|uniprotkb:Q9BT10|uniprotkb:Q5TBZ3|uniprotkb:Q96FE1|uniprotkb:Q8N558|uniprotkb:Q8WV46|uniprotkb:Q96CQ3|uniprotkb:Q8TCW8|uniprotkb:Q96NU3|uniprotkb:Q5HYB5|uniprotkb:Q96I66|uniprotkb:Q9BVB2|uniprotkb:B6EDE0 psi-mi:p0c6x7-pro_0000037318(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:snp47_human(display_long)|uniprotkb:SNAP47(gene name)|psi-mi:SNAP47(display_short)|uniprotkb:C1orf142(gene name synonym)|uniprotkb:Epididymis luminal protein 170(gene name synonym)|uniprotkb:HEL170(gene name synonym)|uniprotkb:SVAP1(gene name synonym)|uniprotkb:Synaptosomal-associated 47 kDa protein(gene name synonym) psi-mi:"MI:0398"(two hybrid pooling approach) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25488525|imex:IM-27830-178 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7843867(chain-parent)|uniprotkb:P0C6X7(chain-parent) interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR000727(Target SNARE coiled-coil region)|refseq:NP_444280.2|refseq:NP_001310864.1|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0012505"(endomembrane system)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0019905"(syntaxin binding)|go:"GO:0031201"(SNARE complex)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0098793"(presynapse)|refseq:XP_016855720.1|refseq:XP_016855721.1 - chain-seq-start:4370|chain-seq-end:5301 - figure legend:ST1|comment:"Library for Y2H screening used: fetal brain"|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/19 2020/03/31 rogid:eeAJDsSyQ9Qfnm1xY+XJWlCGwWY694009 rogid:hKGKMfU5GPf/qU+vuwByphqX3NA9606 rigid:L+ahujoClcqQtn16BCV3YXYIexw false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P0C6X7-PRO_0000037309 uniprotkb:Q9Y4W2 intact:EBI-25475797 intact:EBI-1051591|uniprotkb:Q5JXQ0|uniprotkb:Q8TEN5|uniprotkb:Q9H9V5|uniprotkb:A9X410|ensembl:ENSP00000363944 psi-mi:p0c6x7-pro_0000037309(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:las1l_human(display_long)|uniprotkb:LAS1L(gene name)|psi-mi:LAS1L(display_short)|uniprotkb:Protein LAS1 homolog(gene name synonym)|uniprotkb:MSTP060(orf name) psi-mi:"MI:0398"(two hybrid pooling approach) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25488511|imex:IM-27830-140 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7843867(chain-parent)|uniprotkb:P0C6X7(chain-parent) refseq:NP_001164120.1|refseq:NP_001164121.1|refseq:NP_112483.1|ensembl:ENSG00000001497(gene)|ensembl:ENST00000374811(transcript)|go:"GO:0000460"(maturation of 5.8S rRNA)|go:"GO:0000470"(maturation of LSU-rRNA)|go:"GO:0003723"(RNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0016020"(membrane)|go:"GO:0030687"(preribosome, large subunit precursor)|go:"GO:0071339"(MLL1 complex)|go:"GO:0090730"(Las1 complex)|interpro:IPR007174(Las1-like)|mint:Q9Y4W2|reactome:R-HSA-6791226 - chain-seq-start:1|chain-seq-end:180 - figure legend:ST1|comment:"Library for Y2H screening used: fetal brain"|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/19 2020/03/31 rogid:qbwEpGmE3J035KnL6QbEZ/HRJAw694009 rogid:1TTE2TCMIwczNaT2SSMLioLkALA9606 rigid:0vkXITeZydQGYNw6u3zwpxOWsPY false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P0C6X7-PRO_0000037309 uniprotkb:Q9UKA8 intact:EBI-25475797 intact:EBI-9091952|uniprotkb:A4GU14|uniprotkb:Q9UKA7|uniprotkb:E7ENV1|uniprotkb:Q5ECL3|uniprotkb:A4LA69|uniprotkb:Q5TGC6|uniprotkb:E7EWD8|uniprotkb:Q9NUC8|uniprotkb:E3VWE2|uniprotkb:E5L4P0|uniprotkb:E5L4P7|uniprotkb:G1FI66|uniprotkb:G1FLF0|ensembl:ENSP00000363516|ensembl:ENSP00000445401 psi-mi:p0c6x7-pro_0000037309(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:rcan3_human(display_long)|uniprotkb:DSCR1L2(gene name synonym)|uniprotkb:Down syndrome candidate region 1-like protein 2(gene name synonym)|uniprotkb:Myocyte-enriched calcineurin-interacting protein 3(gene name synonym)|uniprotkb:Regulator of calcineurin 3(gene name synonym)|uniprotkb:RCAN3(gene name)|psi-mi:RCAN3(display_short) psi-mi:"MI:0398"(two hybrid pooling approach) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25488504|imex:IM-27830-20 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7843867(chain-parent)|uniprotkb:P0C6X7(chain-parent) refseq:NP_001238911.1|refseq:NP_001238912.1|refseq:NP_001238914.1|refseq:NP_038469.1|refseq:NP_001238906.1|refseq:NP_001238907.1|refseq:NP_001238908.1|refseq:NP_001238909.1|refseq:NP_001238910.1|refseq:NP_001238913.1|ensembl:ENSG00000117602(gene)|ensembl:ENST00000374395(transcript)|ensembl:ENST00000538532(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008597"(calcium-dependent protein serine/threonine phosphatase regulator activity)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019902"(phosphatase binding)|go:"GO:0031013"(troponin I binding)|interpro:IPR006931(Calcipressin)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034923|interpro:IPR035979 - chain-seq-start:1|chain-seq-end:180 - figure legend:ST1|comment:"Library for Y2H screening used: ORFeome"|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/19 2020/03/31 rogid:qbwEpGmE3J035KnL6QbEZ/HRJAw694009 rogid:GcjmPxKst3ISAOr1WMhJLrYq8JY9606 rigid:yBJ2AnAxgG3aUtRij6HmOwenhHI false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P0C6X7-PRO_0000037309 uniprotkb:O43447 intact:EBI-25475797 intact:EBI-1055615|intact:EBI-6190037|uniprotkb:A6NNE7|ensembl:ENSP00000503384|ensembl:ENSP00000503489|ensembl:ENSP00000503922|ensembl:ENSP00000504108|ensembl:ENSP00000504595|ensembl:ENSP00000361630|ensembl:ENSP00000306614 psi-mi:p0c6x7-pro_0000037309(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:ppih_human(display_long)|uniprotkb:U-snRNP-associated cyclophilin SnuCyp-20(gene name synonym)|uniprotkb:Small nuclear ribonucleoprotein particle-specific cyclophilin H(gene name synonym)|uniprotkb:PPIH(gene name)|psi-mi:PPIH(display_short)|uniprotkb:CYP20(gene name synonym)|uniprotkb:CYPH(gene name synonym)|uniprotkb:Rotamase H(gene name synonym) psi-mi:"MI:0398"(two hybrid pooling approach) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25488497|imex:IM-27830-138 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7843867(chain-parent)|uniprotkb:P0C6X7(chain-parent) refseq:NP_006338.1|refseq:XP_005270419.1|ensembl:ENST00000304979(transcript)|ensembl:ENST00000372550(transcript)|ensembl:ENST00000676675(transcript)|ensembl:ENST00000677900(transcript)|ensembl:ENST00000678038(transcript)|ensembl:ENST00000678333(transcript)|ensembl:ENST00000678803(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006457"(protein folding)|go:"GO:0016018"(cyclosporin A binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071001"(U4/U6 snRNP)|interpro:IPR002130(Peptidyl-prolyl cis-trans isomerase, cyclophilin-type)|interpro:IPR020892|interpro:IPR024936|interpro:IPR029000|mint:O43447|rcsb pdb:1MZW|rcsb pdb:1QOI|rcsb pdb:5O9Z|rcsb pdb:6AHD|reactome:R-HSA-72163|ensembl:ENSG00000171960(gene)|refseq:NP_001317439.1|refseq:XP_016855546.1|refseq:XP_016855547.1|refseq:XP_016855548.1 - chain-seq-start:1|chain-seq-end:180 - figure legend:ST1|comment:"Library for Y2H screening used: fetal brain"|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/19 2020/03/31 rogid:qbwEpGmE3J035KnL6QbEZ/HRJAw694009 rogid:6gE98w/LLmT7FlCBnaBDk+GWvQU9606 rigid:qq/wuv0iWQs0JoZye2WztzC4oPo false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P0C6X7-PRO_0000037309 uniprotkb:Q13427 intact:EBI-25475797 intact:EBI-396072|uniprotkb:O00706|uniprotkb:Q96DG9|uniprotkb:Q53R40|uniprotkb:Q53SN4|ensembl:ENSP00000260970|ensembl:ENSP00000407083|ensembl:ENSP00000408683|ensembl:ENSP00000502997|ensembl:ENSP00000503136|ensembl:ENSP00000503525|uniprotkb:D3DPC5|uniprotkb:D3DPC6 psi-mi:p0c6x7-pro_0000037309(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:ppig_human(display_long)|uniprotkb:PPIG(gene name)|psi-mi:PPIG(display_short)|uniprotkb:Cyclophilin G(gene name synonym)|uniprotkb:Clk-associating RS-cyclophilin(gene name synonym)|uniprotkb:CASP10(gene name synonym)|uniprotkb:Rotamase G(gene name synonym) psi-mi:"MI:0398"(two hybrid pooling approach) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25488490|imex:IM-27830-40 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7843867(chain-parent)|uniprotkb:P0C6X7(chain-parent) refseq:NP_004783.2|ensembl:ENSG00000138398(gene)|ensembl:ENST00000260970(transcript)|ensembl:ENST00000433207(transcript)|ensembl:ENST00000448752(transcript)|ensembl:ENST00000676756(transcript)|ensembl:ENST00000678499(transcript)|ensembl:ENST00000679107(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003723"(RNA binding)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008380"(RNA splicing)|go:"GO:0016018"(cyclosporin A binding)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR002130(Peptidyl-prolyl cis-trans isomerase, cyclophilin-type)|interpro:IPR020892|interpro:IPR029000|mint:Q13427|rcsb pdb:2GW2|rcsb pdb:2WFI|rcsb pdb:2WFJ|rcsb pdb:5YZG|go:"GO:0006457"(protein folding)|refseq:XP_005247023.1|refseq:XP_005247024.1 - chain-seq-start:1|chain-seq-end:180 - figure legend:ST1|comment:"Library for Y2H screening used: brain"|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/19 2020/03/31 rogid:qbwEpGmE3J035KnL6QbEZ/HRJAw694009 rogid:gp1Pqv5G8E+PrPmp+BtUSSIkD/89606 rigid:sqdrig/dgD9sPMytUqoSAGDUpY8 false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P0C6X7-PRO_0000037309 uniprotkb:P62942 intact:EBI-25475797 intact:EBI-1027571|uniprotkb:P20071|uniprotkb:Q4VC47|uniprotkb:Q6FGD9|uniprotkb:Q6LEU3|uniprotkb:Q9H103|uniprotkb:Q9H566|uniprotkb:D3DVW6|ensembl:ENSP00000371138|ensembl:ENSP00000371143|ensembl:ENSP00000383003|ensembl:ENSP00000503033|ensembl:ENSP00000503152 psi-mi:p0c6x7-pro_0000037309(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:fkb1a_human(display_long)|uniprotkb:FKBP1A(gene name)|psi-mi:FKBP1A(display_short)|uniprotkb:FKBP1(gene name synonym)|uniprotkb:FKBP12(gene name synonym)|uniprotkb:FK506-binding protein 1A(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:Immunophilin FKBP12(gene name synonym)|uniprotkb:12 kDa FK506-binding protein(gene name synonym)|uniprotkb:Calstabin-1(gene name synonym) psi-mi:"MI:0398"(two hybrid pooling approach) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25488483|imex:IM-27830-38 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7843867(chain-parent)|uniprotkb:P0C6X7(chain-parent) ensembl:ENSG00000088832(gene)|ensembl:ENST00000381719(transcript)|ensembl:ENST00000381724(transcript)|ensembl:ENST00000400137(transcript)|ensembl:ENST00000677335(transcript)|ensembl:ENST00000678408(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005527"(macrolide binding)|go:"GO:0005528"(FK506 binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006458"('de novo' protein folding)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0014802"(terminal cisterna)|go:"GO:0016020"(membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0030018"(Z disc)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031312"(extrinsic component of organelle membrane)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032925"(regulation of activin receptor signaling pathway)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0042026"(protein refolding)|go:"GO:0042110"(T cell activation)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0046332"(SMAD binding)|go:"GO:0048185"(activin binding)|go:"GO:0050776"(regulation of immune response)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0060347"(heart trabecula formation)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0098562"(cytoplasmic side of membrane)|go:"GO:1902991"(regulation of amyloid precursor protein catabolic process)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990425"(ryanodine receptor complex)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|rcsb pdb:1A7X|rcsb pdb:1B6C|rcsb pdb:1BKF|rcsb pdb:1BL4|rcsb pdb:1D6O|rcsb pdb:1D7H|rcsb pdb:1D7I|rcsb pdb:1D7J|rcsb pdb:1EYM|rcsb pdb:1F40|rcsb pdb:1FAP|rcsb pdb:1FKB|rcsb pdb:1FKD|rcsb pdb:1FKF|rcsb pdb:1FKG|rcsb pdb:1FKH|rcsb pdb:1FKI|rcsb pdb:2DG4|rcsb pdb:2DG9|rcsb pdb:2FAP|rcsb pdb:2FKE|rcsb pdb:2ND5|rcsb pdb:2PPN|rcsb pdb:2PPO|rcsb pdb:2PPP|rcsb pdb:2RSE|rcsb pdb:3FAP|rcsb pdb:1FKJ|rcsb pdb:3H9R|rcsb pdb:3MDY|rcsb pdb:4DH0|rcsb pdb:4FAP|rcsb pdb:1FKR|rcsb pdb:4IPX|rcsb pdb:4N19|rcsb pdb:4ODP|rcsb pdb:4ODQ|rcsb pdb:4ODR|rcsb pdb:5I7P|rcsb pdb:5I7Q|rcsb pdb:6I1S|rcsb pdb:1FKS|rcsb pdb:6M4U|rcsb pdb:6OQA|rcsb pdb:6VCU|rcsb pdb:6YF0|rcsb pdb:6YF1|rcsb pdb:6YF2|rcsb pdb:6YF3|reactome:R-HSA-166208|rcsb pdb:1FKT|reactome:R-HSA-2025928|reactome:R-HSA-2173789|reactome:R-HSA-2173791|reactome:R-HSA-3656535|rcsb pdb:1J4H|rcsb pdb:1J4I|reactome:R-HSA-9679191|rcsb pdb:1J4R|rcsb pdb:1NSG|rcsb pdb:1QPF|rcsb pdb:1QPL|rcsb pdb:2DG3|refseq:NP_000792.1|refseq:NP_463460.1|dip:DIP-29710N - chain-seq-start:1|chain-seq-end:180 - figure legend:ST1|comment:"Library for Y2H screening used: fetal brain"|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/19 2020/03/31 rogid:qbwEpGmE3J035KnL6QbEZ/HRJAw694009 rogid:3eikHNIIVs8AFM7PYVWurI/9KUY9606 rigid:12k3v6POf9dqKbeZN+eWt1BHJNc false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P0C6X7-PRO_0000037318 uniprotkb:O95299 intact:EBI-25487684 intact:EBI-1246361|uniprotkb:Q8WXC9|ensembl:ENSP00000252711|ensembl:ENSP00000503956|ensembl:ENSP00000504765 psi-mi:p0c6x7-pro_0000037318(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:nduaa_human(display_long)|uniprotkb:NDUFA10(gene name)|psi-mi:NDUFA10(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase 42 kDa subunit(gene name synonym)|uniprotkb:Complex I-42kD(gene name synonym) psi-mi:"MI:0398"(two hybrid pooling approach) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25488567|imex:IM-27830-180 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7843867(chain-parent)|uniprotkb:P0C6X7(chain-parent) refseq:NP_004535.1|ensembl:ENSG00000130414(gene)|ensembl:ENST00000252711(transcript)|ensembl:ENST00000676929(transcript)|ensembl:ENST00000678158(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR015828(NADH-ubiquinone oxidoreductase, 42 kDa subunit)|interpro:IPR027417|interpro:IPR031314|mint:O95299|rcsb pdb:5XTC|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 - chain-seq-start:4370|chain-seq-end:5301 - figure legend:ST1|comment:"Library for Y2H screening used: brain"|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/19 2020/03/31 rogid:eeAJDsSyQ9Qfnm1xY+XJWlCGwWY694009 rogid:8jwJPJ0rD9H7A4AzxPd186tpXYs9606 rigid:96Ttq85gSbqTEa6T4XAHNjSheJk false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P0C6X7-PRO_0000037318 uniprotkb:Q8TD31 intact:EBI-25487684 intact:EBI-949834|ensembl:ENSP00000365442|ensembl:ENSP00000372832|ensembl:ENSP00000373019|ensembl:ENSP00000383205|ensembl:ENSP00000393042|ensembl:ENSP00000408012|uniprotkb:Q9NRK8|uniprotkb:Q9NWY9|uniprotkb:Q9NXJ4|uniprotkb:Q9NXK3|uniprotkb:Q9Y6W1|uniprotkb:Q9Y6W2|uniprotkb:Q5SQ82|uniprotkb:Q5STE9|uniprotkb:A2ABH6|uniprotkb:Q2TB67|uniprotkb:E9PE84 psi-mi:p0c6x7-pro_0000037318(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:cchcr_human(display_long)|uniprotkb:Alpha-helical coiled-coil rod protein(gene name synonym)|uniprotkb:Putative gene 8 protein(gene name synonym)|uniprotkb:CCHCR1(gene name)|psi-mi:CCHCR1(display_short)|uniprotkb:C6orf18(gene name synonym)|uniprotkb:HCR(gene name synonym) psi-mi:"MI:0398"(two hybrid pooling approach) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25488553|imex:IM-27830-144 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7843867(chain-parent)|uniprotkb:P0C6X7(chain-parent) ensembl:ENSG00000204536(gene)|ensembl:ENSG00000206355(gene)|ensembl:ENSG00000206457(gene)|ensembl:ENSG00000234114(gene)|ensembl:ENST00000376266(transcript)|ensembl:ENST00000383341(transcript)|ensembl:ENST00000383527(transcript)|ensembl:ENST00000400352(transcript)|ensembl:ENST00000416163(transcript)|ensembl:ENST00000425620(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0030154"(cell differentiation)|go:"GO:0042802"(identical protein binding)|interpro:IPR009800(Alpha helical coiled-coil rod)|go:"GO:0005814"(centriole)|refseq:XP_016866451.1|refseq:XP_016866452.1|refseq:XP_016866453.1|refseq:XP_016866454.1|refseq:XP_016866455.1|refseq:XP_016866456.1|refseq:XP_016866457.1|refseq:NP_001099033.1|refseq:NP_001099034.1|refseq:NP_061925.2|refseq:XP_011513005.1|dip:DIP-40394N - chain-seq-start:4370|chain-seq-end:5301 - figure legend:ST1|comment:"Library for Y2H screening used: ORFeome"|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/19 2020/03/31 rogid:eeAJDsSyQ9Qfnm1xY+XJWlCGwWY694009 rogid:wgzA1VMrSlj7h29Hpmg5L0IOAJU9606 rigid:P1qO0Jsek/1+bcEHtcvr8rSkjbg false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P0C6X7-PRO_0000037318 uniprotkb:P20231 intact:EBI-25487684 intact:EBI-1761383|uniprotkb:O95827|uniprotkb:Q15664|uniprotkb:Q9UQI6|uniprotkb:Q9UQI7|uniprotkb:D2E6S0|uniprotkb:D2E6S2|ensembl:ENSP00000482743 psi-mi:p0c6x7-pro_0000037318(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:tryb2_human(display_long)|uniprotkb:TPSB2(gene name)|psi-mi:TPSB2(display_short)|uniprotkb:TPS2(gene name synonym)|uniprotkb:Tryptase II(gene name synonym) psi-mi:"MI:0398"(two hybrid pooling approach) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25488546|imex:IM-27830-142 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7843867(chain-parent)|uniprotkb:P0C6X7(chain-parent) refseq:NP_077078.5|refseq:NP_003285.2|ensembl:ENSG00000197253(gene)|ensembl:ENST00000606293(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0006508"(proteolysis)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR018114|interpro:IPR033116|interpro:IPR043504|rcsb pdb:1A0L|rcsb pdb:1AAO|rcsb pdb:2BM2|rcsb pdb:2FPZ|rcsb pdb:2FS8|rcsb pdb:2FS9|rcsb pdb:2FWW|rcsb pdb:2FXR|rcsb pdb:2GDD|rcsb pdb:2ZA5|rcsb pdb:3V7T - chain-seq-start:4370|chain-seq-end:5301 - figure legend:ST1|comment:"Library for Y2H screening used: ORFeome"|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/19 2020/03/31 rogid:eeAJDsSyQ9Qfnm1xY+XJWlCGwWY694009 rogid:I/QoDM5Sfej1YpvO9kbj9/wUwBI9606 rigid:f2ecyb4vXTomd6VD2G8qQjPelrg false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P0C6X7-PRO_0000037318 uniprotkb:P30876 intact:EBI-25487684 intact:EBI-394712|uniprotkb:Q8IZ61|uniprotkb:A8K1A8|ensembl:ENSP00000312735|ensembl:ENSP00000370625 psi-mi:p0c6x7-pro_0000037318(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:rpb2_human(display_long)|uniprotkb:POLR2B(gene name)|psi-mi:POLR2B(display_short)|uniprotkb:DNA-directed RNA polymerase II subunit B(gene name synonym)|uniprotkb:RNA polymerase II subunit B2(gene name synonym)|uniprotkb:RNA polymerase II subunit 2(gene name synonym)|uniprotkb:DNA-directed RNA polymerase II 140 kDa polypeptide(gene name synonym) psi-mi:"MI:0398"(two hybrid pooling approach) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25488539|imex:IM-27830-100 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7843867(chain-parent)|uniprotkb:P0C6X7(chain-parent) refseq:NP_000929.1|refseq:NP_001290197.1|refseq:NP_001290198.1|ensembl:ENSG00000047315(gene)|ensembl:ENST00000314595(transcript)|ensembl:ENST00000381227(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005665"(RNA polymerase II, core complex)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0016020"(membrane)|go:"GO:0032549"(ribonucleoside binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR007120(DNA-directed RNA polymerase, subunit 2, domain 6)|interpro:IPR007121(RNA polymerase, beta subunit, conserved site)|interpro:IPR007641(RNA polymerase Rpb2, domain 7)|interpro:IPR007642(RNA polymerase Rpb2, domain 2)|interpro:IPR007644(RNA polymerase, beta subunit, protrusion)|interpro:IPR007645(RNA polymerase Rpb2, domain 3)|interpro:IPR007646(RNA polymerase Rpb2, domain 4)|interpro:IPR007647(RNA polymerase Rpb2, domain 5)|interpro:IPR014724(RNA polymerase Rpb2, OB-fold)|interpro:IPR015712(DNA-directed RNA polymerase, subunit 2)|interpro:IPR037033|interpro:IPR037034|mint:P30876|rcsb pdb:5IY6|rcsb pdb:5IY7|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5IYA|rcsb pdb:5IYB|rcsb pdb:5IYC|rcsb pdb:5IYD|rcsb pdb:6DRD|rcsb pdb:6O9L|rcsb pdb:6XRE|rcsb pdb:7LBM|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167242|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-168325|reactome:R-HSA-203927|reactome:R-HSA-5578749|reactome:R-HSA-5601884|reactome:R-HSA-5617472|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-6803529|reactome:R-HSA-6807505|reactome:R-HSA-72086|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72203|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8851708|reactome:R-HSA-9018519|reactome:R-HSA-9670095|dip:DIP-32910N - chain-seq-start:4370|chain-seq-end:5301 - figure legend:ST1|comment:"Library for Y2H screening used: brain"|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/19 2020/03/31 rogid:eeAJDsSyQ9Qfnm1xY+XJWlCGwWY694009 rogid:YhEjtfLk2QnbRPefOp8ZHX0ejak9606 rigid:4f2aXO76vJLs/ynbN5WNIlqyBpo false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P0C6X7-PRO_0000037318 uniprotkb:Q15661 intact:EBI-25487684 intact:EBI-1761369|intact:EBI-1762849|uniprotkb:D2E6R9|uniprotkb:D2E6S1|uniprotkb:P15157|uniprotkb:Q9H2Y5|uniprotkb:Q15663|uniprotkb:Q9H2Y4|uniprotkb:Q9UQI1|uniprotkb:Q6B052|ensembl:ENSP00000343577|ensembl:ENSP00000502948 psi-mi:p0c6x7-pro_0000037318(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:tryb1_human(display_long)|uniprotkb:TPSAB1(gene name)|psi-mi:TPSAB1(display_short)|uniprotkb:TPSB1(gene name synonym)|uniprotkb:Tryptase I(gene name synonym)|uniprotkb:TPS1(gene name synonym)|uniprotkb:TPS2(gene name synonym)|uniprotkb:Tryptase alpha-1(gene name synonym) psi-mi:"MI:0398"(two hybrid pooling approach) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25488532|imex:IM-27830-218 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7843867(chain-parent)|uniprotkb:P0C6X7(chain-parent) refseq:NP_003285.2|ensembl:ENSG00000172236(gene)|ensembl:ENST00000338844(transcript)|ensembl:ENST00000677899(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006508"(proteolysis)|go:"GO:0006952"(defense response)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0042802"(identical protein binding)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR018114|interpro:IPR033116|interpro:IPR043504|rcsb pdb:1LTO|rcsb pdb:2F9N|rcsb pdb:2F9O|rcsb pdb:2F9P|rcsb pdb:2ZEB|rcsb pdb:2ZEC|rcsb pdb:4A6L|rcsb pdb:4MPU|rcsb pdb:4MPV|rcsb pdb:4MPW|rcsb pdb:4MPX|rcsb pdb:4MQA|rcsb pdb:5F03|rcsb pdb:5WI6|rcsb pdb:6O1F|rcsb pdb:6P0P|rcsb pdb:6VVU|reactome:R-HSA-1592389 - chain-seq-start:4370|chain-seq-end:5301 - figure legend:ST1|comment:"Library for Y2H screening used: ORFeome"|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/19 2020/03/31 rogid:eeAJDsSyQ9Qfnm1xY+XJWlCGwWY694009 rogid:I/QoDM5Sfej1YpvO9kbj9/wUwBI9606 rigid:f2ecyb4vXTomd6VD2G8qQjPelrg false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P0C6X7-PRO_0000037318 uniprotkb:Q99471 intact:EBI-25487684 intact:EBI-357275|ensembl:ENSP00000334188|ensembl:ENSP00000447942|intact:EBI-1047551|uniprotkb:A8K9A8|uniprotkb:Q54AA8|uniprotkb:Q9C083|uniprotkb:Q9C084 psi-mi:p0c6x7-pro_0000037318(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:pfd5_human(display_long)|uniprotkb:c-Myc-binding protein Mm-1(gene name synonym)|uniprotkb:PFDN5(gene name)|psi-mi:PFDN5(display_short)|uniprotkb:MM1(gene name synonym)|uniprotkb:Myc modulator 1(gene name synonym)|uniprotkb:PFD5(gene name synonym) psi-mi:"MI:0398"(two hybrid pooling approach) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25488560|imex:IM-27830-42 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7843867(chain-parent)|uniprotkb:P0C6X7(chain-parent) ensembl:ENSG00000123349(gene)|ensembl:ENST00000334478(transcript)|ensembl:ENST00000551018(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006457"(protein folding)|go:"GO:0016272"(prefoldin complex)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|interpro:IPR004127(Prefoldin alpha-like)|interpro:IPR009053(Prefoldin)|interpro:IPR011599(Prefoldin alpha subunit)|mint:Q99471|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|reactome:R-HSA-389957|refseq:NP_002615.2|refseq:NP_665904.1|dip:DIP-28155N - chain-seq-start:4370|chain-seq-end:5301 - figure legend:ST1|comment:"Library for Y2H screening used: brain"|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/19 2020/03/31 rogid:eeAJDsSyQ9Qfnm1xY+XJWlCGwWY694009 rogid:Cm4km207qcfDJYRUCIwUxMBT4tE9606 rigid:u1qdEKqNCZkukIfMBkJ2ev98k2g false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P0C6X7-PRO_0000037318 uniprotkb:Q99426 intact:EBI-25487684 intact:EBI-764356|uniprotkb:O00111|uniprotkb:O00674|uniprotkb:O14728|uniprotkb:Q6FGY5|ensembl:ENSP00000221855 psi-mi:p0c6x7-pro_0000037318(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:tbcb_human(display_long)|uniprotkb:Tubulin-specific chaperone B(gene name synonym)|uniprotkb:Cytoskeleton-associated protein 1(gene name synonym)|uniprotkb:Cytoskeleton-associated protein CKAPI(gene name synonym)|uniprotkb:TBCB(gene name)|psi-mi:TBCB(display_short)|uniprotkb:CG22(gene name synonym)|uniprotkb:CKAP1(gene name synonym) psi-mi:"MI:0398"(two hybrid pooling approach) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25488574|imex:IM-27830-78 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7843867(chain-parent)|uniprotkb:P0C6X7(chain-parent) refseq:NP_001272.2|refseq:NP_001287900.1|dip:DIP-34409N|ensembl:ENSG00000105254(gene)|ensembl:ENST00000221855(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007399"(nervous system development)|go:"GO:0015630"(microtubule cytoskeleton)|interpro:IPR000626(Ubiquitin)|interpro:IPR000938(Cytoskeleton-associated protein, CAP-Gly)|interpro:IPR029071|interpro:IPR036859|reactome:R-HSA-389977|go:"GO:0030154"(cell differentiation) - chain-seq-start:4370|chain-seq-end:5301 - figure legend:ST1|comment:"Library for Y2H screening used: fetal brain"|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/19 2020/03/31 rogid:eeAJDsSyQ9Qfnm1xY+XJWlCGwWY694009 rogid:HHMamwtPQscu/rkhdarbQl6/hcw9606 rigid:sSCxC663qZM1KEFo/uHJuZfS02I false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P0C6X7-PRO_0000037318 uniprotkb:P51948 intact:EBI-25487684 intact:EBI-716139|uniprotkb:Q15817|uniprotkb:G3V1U8|uniprotkb:Q6ICQ7|ensembl:ENSP00000261245 psi-mi:p0c6x7-pro_0000037318(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:mat1_human(display_long)|uniprotkb:RING finger protein MAT1(gene name synonym)|uniprotkb:Menage a trois(gene name synonym)|uniprotkb:CDK7/cyclin-H assembly factor(gene name synonym)|uniprotkb:p36(gene name synonym)|uniprotkb:p35(gene name synonym)|uniprotkb:Cyclin-G1-interacting protein(gene name synonym)|uniprotkb:RING finger protein 66(gene name synonym)|uniprotkb:MNAT1(gene name)|psi-mi:MNAT1(display_short)|uniprotkb:CAP35(gene name synonym)|uniprotkb:MAT1(gene name synonym)|uniprotkb:RNF66(gene name synonym) psi-mi:"MI:0398"(two hybrid pooling approach) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25488581|imex:IM-27830-44 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7843867(chain-parent)|uniprotkb:P0C6X7(chain-parent) refseq:NP_001171434.1|refseq:NP_002422.1|interpro:IPR017907|rcsb pdb:1G25|rcsb pdb:6NMI|rcsb pdb:6O9L|rcsb pdb:6O9M|rcsb pdb:6TUN|rcsb pdb:6XBZ|rcsb pdb:6XD3|rcsb pdb:7B5O|rcsb pdb:7B5Q|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|rcsb pdb:7NVW|rcsb pdb:7NVX|rcsb pdb:7NVY|rcsb pdb:7NVZ|rcsb pdb:7NW0|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69656|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|interpro:IPR015877(Cdk-activating kinase assembly factor, MAT1)|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|ensembl:ENST00000261245(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007512"(adult heart development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0019907"(cyclin-dependent protein kinase activating kinase holoenzyme complex)|go:"GO:0021591"(ventricular system development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051592"(response to calcium ion)|go:"GO:0061575"(cyclin-dependent protein serine/threonine kinase activator activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070516"(CAK-ERCC2 complex)|go:"GO:0070985"(transcription factor TFIIK complex)|ensembl:ENSG00000020426(gene)|go:"GO:1905775"(negative regulation of DNA helicase activity)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR004575("Cdk-activating kinase assembly factor (MAT1)")|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|reactome:R-HSA-8939236|refseq:XP_005267744.1 - chain-seq-start:4370|chain-seq-end:5301 - figure legend:ST1|comment:"Library for Y2H screening used: brain"|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/19 2020/03/31 rogid:eeAJDsSyQ9Qfnm1xY+XJWlCGwWY694009 rogid:5Y/RExMrWjtftdbXuadagc0b+Kc9606 rigid:Sble/H9m9L0MUIYQSVsKSc49Zbw false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P0C6X7-PRO_0000037311 uniprotkb:Q13064 intact:EBI-25474079 intact:EBI-2340269|ensembl:ENSP00000313881 psi-mi:p0c6x7-pro_0000037311(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:mkrn3_human(display_long)|uniprotkb:MKRN3(gene name)|psi-mi:MKRN3(display_short)|uniprotkb:D15S9(gene name synonym)|uniprotkb:RNF63(gene name synonym)|uniprotkb:ZNF127(gene name synonym)|uniprotkb:Zinc finger protein 127(gene name synonym)|uniprotkb:RING finger protein 63(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase makorin-3(gene name synonym) psi-mi:"MI:0398"(two hybrid pooling approach) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25488700|imex:IM-27830-118 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7843867(chain-parent) refseq:NP_005655.1|ensembl:ENSG00000179455(gene)|ensembl:ENST00000314520(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003723"(RNA binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000571(Zinc finger, CCCH-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR026294|interpro:IPR031644|interpro:IPR036855|interpro:IPR041367|mint:Q13064 - chain-seq-start:819|chain-seq-end:2740 - figure legend:ST1|comment:"Library for Y2H screening used: ORFeome"|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/19 2020/03/31 rogid:NKZ5d0D2HjefhmJQwgHz+M1lSt8694009 rogid:3sZzqtO8FoR/vVI64iFKb0iuuSc9606 rigid:g8PaooJ1p46UujDoW3roQMv2N2I false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P09630 uniprotkb:P0C6X7-PRO_0000037318 intact:EBI-9057196|uniprotkb:B2RBV2|uniprotkb:Q6DK09|ensembl:ENSP00000243108 intact:EBI-25487684 psi-mi:hxc6_human(display_long)|uniprotkb:HOXC6(gene name)|psi-mi:HOXC6(display_short)|uniprotkb:HOX3C(gene name synonym)|uniprotkb:Homeobox protein CP25(gene name synonym)|uniprotkb:Homeobox protein HHO.C8(gene name synonym)|uniprotkb:Homeobox protein Hox-3C(gene name synonym) psi-mi:p0c6x7-pro_0000037318(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:"MI:0398"(two hybrid pooling approach) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25488588|imex:IM-27830-220 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004494.1|refseq:NP_710160.1|ensembl:ENSG00000197757(gene)|ensembl:ENST00000243108(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007275"(multicellular organism development)|go:"GO:0009952"(anterior/posterior pattern specification)|interpro:IPR001356(Homeobox)|interpro:IPR001827(Homeobox protein, antennapedia type)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|interpro:IPR020479 intact:EBI-7843867(chain-parent)|uniprotkb:P0C6X7(chain-parent) - - chain-seq-start:4370|chain-seq-end:5301 figure legend:ST1|comment:"Library for Y2H screening used: ORFeome"|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/19 2020/03/31 rogid:uMymV17aUMMHjrOY+Fk8rArpOGs9606 rogid:eeAJDsSyQ9Qfnm1xY+XJWlCGwWY694009 rigid:a1WTTLjkJTEfHCfNiFzErkdZxCU false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P0C6X7-PRO_0000037319 uniprotkb:Q8N488 intact:EBI-25487926 intact:EBI-752324|uniprotkb:Q9P2W5|uniprotkb:Q9UMW4|ensembl:ENSP00000419494 psi-mi:p0c6x7-pro_0000037319(display_long)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)|uniprotkb:rep(gene name)|psi-mi:rep(display_short) psi-mi:rybp_human(display_long)|uniprotkb:Death effector domain-associated factor(gene name synonym)|uniprotkb:YY1 and E4TF1-associated factor 1(gene name synonym)|uniprotkb:Apoptin-associating protein 1(gene name synonym)|uniprotkb:RYBP(gene name)|psi-mi:RYBP(display_short)|uniprotkb:DEDAF(gene name synonym)|uniprotkb:YEAF1(gene name synonym) psi-mi:"MI:0398"(two hybrid pooling approach) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25488595|imex:IM-27830-158 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:P0C6X7(chain-parent)|intact:EBI-7843867(chain-parent) refseq:NP_036366.3|dip:DIP-41435N|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0007275"(multicellular organism development)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR033774|interpro:IPR036443|interpro:IPR039958|mint:Q8N488|rcsb pdb:3IXS|reactome:R-HSA-8939243|reactome:R-HSA-8953750|ensembl:ENSG00000163602(gene)|ensembl:ENST00000477973(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity) - chain-seq-start:5302|chain-seq-end:5902 - figure legend:ST1|comment:"Library for Y2H screening used: ORFeome"|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/19 2020/03/31 rogid:p7KzZyyr+yMS7ZiMTBx4VVZRzGc694009 rogid:t9ef8aO/5xEAB3hMlElJCktEIOU9606 rigid:xd3gCCM8MKMUGbRoc+F4cMWNWWU false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P0C6X7-PRO_0000037319 uniprotkb:P27448 intact:EBI-25487926 intact:EBI-707595|uniprotkb:O60219|uniprotkb:Q8TB41|uniprotkb:Q8WX83|uniprotkb:Q96RG1|uniprotkb:Q9UMY9|uniprotkb:Q9UN34|uniprotkb:Q86TT8|uniprotkb:A0A0A0MQR8|uniprotkb:A0A0A0MST9|uniprotkb:A0A0A0MT23|ensembl:ENSP00000411397 psi-mi:p0c6x7-pro_0000037319(display_long)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)|uniprotkb:rep(gene name)|psi-mi:rep(display_short) psi-mi:mark3_human(display_long)|uniprotkb:Cdc25C-associated protein kinase 1(gene name synonym)|uniprotkb:C-TAK1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase p78(gene name synonym)|uniprotkb:Ser/Thr protein kinase PAR-1(gene name synonym)|uniprotkb:Protein kinase STK10(gene name synonym)|uniprotkb:MARK3(gene name)|psi-mi:MARK3(display_short)|uniprotkb:CTAK1(gene name synonym)|uniprotkb:EMK2(gene name synonym)|uniprotkb:ELKL motif kinase 2(gene name synonym) psi-mi:"MI:0398"(two hybrid pooling approach) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25488602|imex:IM-27830-222 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:P0C6X7(chain-parent)|intact:EBI-7843867(chain-parent) refseq:NP_001122390.2|refseq:NP_001122391.2|refseq:NP_001122392.2|refseq:NP_001122393.2|refseq:NP_002367.5|dip:DIP-34637N|ensembl:ENSG00000075413(gene)|ensembl:ENST00000429436(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030425"(dendrite)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0048156"(tau protein binding)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001772(Kinase-associated KA1)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|interpro:IPR033628|mint:P27448|rcsb pdb:2QNJ|rcsb pdb:3FE3|rcsb pdb:7O94|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223 - chain-seq-start:5302|chain-seq-end:5902 - figure legend:ST1|comment:"Library for Y2H screening used: brain"|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/19 2020/03/31 rogid:p7KzZyyr+yMS7ZiMTBx4VVZRzGc694009 rogid:YoMdp32OqT0OCgUUBwxSEHmA+vs9606 rigid:H5jJYGFuYt5mwMHtdmlaK+lJNOs false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P0C6X7-PRO_0000037319 uniprotkb:Q7KZI7 intact:EBI-25487926 intact:EBI-516560|uniprotkb:Q15449|uniprotkb:Q15524|uniprotkb:Q5XGA3|uniprotkb:Q68A18|uniprotkb:Q96HB3|uniprotkb:Q96RG0|ensembl:ENSP00000385751 psi-mi:p0c6x7-pro_0000037319(display_long)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)|uniprotkb:rep(gene name)|psi-mi:rep(display_short) psi-mi:mark2_human(display_long)|uniprotkb:MAP/microtubule affinity-regulating kinase 2(gene name synonym)|uniprotkb:ELKL motif kinase 1(gene name synonym)|uniprotkb:PAR1 homolog(gene name synonym)|uniprotkb:MARK2(gene name)|psi-mi:MARK2(display_short)|uniprotkb:EMK1(gene name synonym)|uniprotkb:PAR1 homolog b(gene name synonym) psi-mi:"MI:0398"(two hybrid pooling approach) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25488609|imex:IM-27830-160 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:P0C6X7(chain-parent)|intact:EBI-7843867(chain-parent) refseq:NP_001034558.2|refseq:NP_001156768.1|refseq:NP_001156769.1|refseq:NP_004945.4|refseq:NP_059672.2|dip:DIP-31321N|ensembl:ENSG00000072518(gene)|ensembl:ENST00000402010(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0001764"(neuron migration)|go:"GO:0003723"(RNA binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008289"(lipid binding)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045296"(cadherin binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048156"(tau protein binding)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030425"(dendrite)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0061564"(axon development)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071963"(establishment or maintenance of cell polarity regulating cell shape)|go:"GO:0097427"(microtubule bundle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904526"(regulation of microtubule binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001772(Kinase-associated KA1)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|mint:Q7KZI7|rcsb pdb:3IEC|rcsb pdb:5EAK|rcsb pdb:5KZ7|rcsb pdb:5KZ8 - chain-seq-start:5302|chain-seq-end:5902 - figure legend:ST1|comment:"Library for Y2H screening used: brain"|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/19 2020/03/31 rogid:p7KzZyyr+yMS7ZiMTBx4VVZRzGc694009 rogid:yfUqSCu4bgkncBd6hRRg5pKkArc9606 rigid:9UpJuAhjxTf0lhIMa6iiS+EZgeQ false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P0C6X7-PRO_0000037319 uniprotkb:O96017 intact:EBI-25487926 intact:EBI-1180783|uniprotkb:Q6QA03|uniprotkb:Q6QA04|uniprotkb:Q6QA05|uniprotkb:Q6QA06|uniprotkb:Q6QA07|uniprotkb:Q6QA08|uniprotkb:Q6QA10|uniprotkb:Q6QA11|uniprotkb:Q6QA12|uniprotkb:Q6QA13|uniprotkb:Q9HCQ8|uniprotkb:Q9UGF0|uniprotkb:Q9UGF1|uniprotkb:B7ZBF3|uniprotkb:B7ZBF4|uniprotkb:B7ZBF5|uniprotkb:Q9HBS5|uniprotkb:A8K3Y9|ensembl:ENSP00000385747|ensembl:ENSP00000386087|ensembl:ENSP00000497000 psi-mi:p0c6x7-pro_0000037319(display_long)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)|uniprotkb:rep(gene name)|psi-mi:rep(display_short) psi-mi:chk2_human(display_long)|uniprotkb:CHEK2(gene name)|psi-mi:CHEK2(display_short)|uniprotkb:CHK2(gene name synonym)|uniprotkb:RAD53(gene name synonym)|uniprotkb:Cds1 homolog(gene name synonym)|uniprotkb:Checkpoint kinase 2(gene name synonym)|uniprotkb:CDS1(gene name synonym)|uniprotkb:CHK2 checkpoint homolog(gene name synonym) psi-mi:"MI:0398"(two hybrid pooling approach) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25488616|imex:IM-27830-224 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:P0C6X7(chain-parent)|intact:EBI-7843867(chain-parent) refseq:XP_016884050.1|refseq:NP_001005735.1|refseq:NP_009125.1|refseq:NP_665861.1|refseq:NP_001244316.1|refseq:XP_011528147.1|dip:DIP-24270N|ensembl:ENSG00000183765(gene)|ensembl:ENST00000404276(transcript)|ensembl:ENST00000405598(transcript)|ensembl:ENST00000650281(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035690"|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0044773"(mitotic DNA damage checkpoint signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051301"(cell division)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1903416"(response to glycoside)|go:"GO:1903926"(cellular response to bisphenol A)|go:"GO:2000002"(negative regulation of DNA damage checkpoint)|go:"GO:2000210"(positive regulation of anoikis)|interpro:IPR000253(Forkhead-associated)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR011009(Protein kinase-like)|mint:O96017|rcsb pdb:1GXC|rcsb pdb:2CN5|rcsb pdb:2CN8|rcsb pdb:2W0J|go:"GO:0090399"(replicative senescence)|rcsb pdb:2W7X|rcsb pdb:2WTC|rcsb pdb:2WTD|rcsb pdb:2XM8|rcsb pdb:2XM9|rcsb pdb:2YCF|rcsb pdb:2YCQ|rcsb pdb:2YCR|rcsb pdb:2YCS|rcsb pdb:2YIQ|rcsb pdb:2YIR|rcsb pdb:2YIT|rcsb pdb:3I6U|rcsb pdb:3I6W|rcsb pdb:3VA4|rcsb pdb:4A9R|rcsb pdb:4A9S|rcsb pdb:4A9T|rcsb pdb:4A9U|rcsb pdb:4BDA|rcsb pdb:4BDB|rcsb pdb:4BDC|rcsb pdb:4BDD|rcsb pdb:4BDE|rcsb pdb:4BDF|rcsb pdb:4BDG|rcsb pdb:4BDH|rcsb pdb:4BDI|rcsb pdb:4BDJ|rcsb pdb:4BDK|reactome:R-HSA-5693565|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804760|reactome:R-HSA-69473|reactome:R-HSA-69541|reactome:R-HSA-69601|reactome:R-HSA-75035|rcsb pdb:2WTI|rcsb pdb:2WTJ|rcsb pdb:2XBJ|rcsb pdb:2XK9 - chain-seq-start:5302|chain-seq-end:5902 - figure legend:ST1|comment:"Library for Y2H screening used: fetal brain"|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/19 2020/03/31 rogid:p7KzZyyr+yMS7ZiMTBx4VVZRzGc694009 rogid:LaDEJtqjPoEJZoj1f6vlZiiaZoI9606 rigid:2qQTBq9wfzRz1TekXezJpb3vSSU false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P0C6X7-PRO_0000037319 uniprotkb:P05155 intact:EBI-25487926 intact:EBI-1223454|uniprotkb:Q547W3|uniprotkb:Q59EI5|uniprotkb:Q96FE0|uniprotkb:A6NMU0|uniprotkb:A8KAI9|uniprotkb:B2R6L5|uniprotkb:Q16304|uniprotkb:Q7Z455|uniprotkb:Q9UC49|uniprotkb:Q9UCF9|uniprotkb:B4E1F0|uniprotkb:B4E1H2|ensembl:ENSP00000278407|ensembl:ENSP00000504807 psi-mi:p0c6x7-pro_0000037319(display_long)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)|uniprotkb:rep(gene name)|psi-mi:rep(display_short) psi-mi:ic1_human(display_long)|uniprotkb:SERPING1(gene name)|psi-mi:SERPING1(display_short)|uniprotkb:C1IN(gene name synonym)|uniprotkb:C1NH(gene name synonym)|uniprotkb:C1 esterase inhibitor(gene name synonym)|uniprotkb:C1-inhibiting factor(gene name synonym)|uniprotkb:Serpin G1(gene name synonym) psi-mi:"MI:0398"(two hybrid pooling approach) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25488623|imex:IM-27830-80 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:P0C6X7(chain-parent)|intact:EBI-7843867(chain-parent) refseq:NP_000053.2|refseq:NP_001027466.1|dip:DIP-45635N|ensembl:ENSG00000149131(gene)|ensembl:ENST00000278407(transcript)|ensembl:ENST00000676670(transcript)|go:"GO:0001869"(negative regulation of complement activation, lectin pathway)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0007568"(aging)|go:"GO:0007596"(blood coagulation)|go:"GO:0008015"(blood circulation)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0042730"(fibrinolysis)|go:"GO:0045087"(innate immune response)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR015553(Protease inhibitor I4, serpin C1)|interpro:IPR023795|interpro:IPR023796|interpro:IPR036186|interpro:IPR042178|interpro:IPR042185|mint:P05155|rcsb pdb:1M6Q|rcsb pdb:2OAY|rcsb pdb:5DU3|rcsb pdb:5DUQ|rcsb pdb:7AKV|reactome:R-HSA-114608|reactome:R-HSA-140837|reactome:R-HSA-9657689|reactome:R-HSA-977606 - chain-seq-start:5302|chain-seq-end:5902 - figure legend:ST1|comment:"Library for Y2H screening used: fetal brain"|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/19 2020/03/31 rogid:p7KzZyyr+yMS7ZiMTBx4VVZRzGc694009 rogid:Y7cqCZ6Ryz51dsi6jM86EXdfeWc9606 rigid:ccuf0iEJaTq4rptt5IfaawyrnhU false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P0C6X7-PRO_0000037319 uniprotkb:Q56VL3 intact:EBI-25487926 intact:EBI-6152758|uniprotkb:Q8N544|uniprotkb:B4DPE7|ensembl:ENSP00000423014 psi-mi:p0c6x7-pro_0000037319(display_long)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)|uniprotkb:rep(gene name)|psi-mi:rep(display_short) psi-mi:ocad2_human(display_long)|uniprotkb:Ovarian carcinoma immunoreactive antigen-like protein(gene name synonym)|uniprotkb:OCIAD2(gene name)|psi-mi:OCIAD2(display_short) psi-mi:"MI:0398"(two hybrid pooling approach) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25488630|imex:IM-27830-82 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:P0C6X7(chain-parent)|intact:EBI-7843867(chain-parent) refseq:NP_001014446.1|refseq:NP_689611.1|refseq:NP_001273702.1|ensembl:ENSG00000145247(gene)|ensembl:ENST00000508632(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006897"(endocytosis)|go:"GO:0009617"(response to bacterium)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061484"(hematopoietic stem cell homeostasis)|interpro:IPR009764(Ovarian carcinoma immunoreactive antigen)|interpro:IPR040187 - chain-seq-start:5302|chain-seq-end:5902 - figure legend:ST1|comment:"Library for Y2H screening used: brain"|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/19 2020/03/31 rogid:p7KzZyyr+yMS7ZiMTBx4VVZRzGc694009 rogid:z4I/nxTOVnbJ/RZhY11VYbBas0g9606 rigid:p1gRC0oTvbdvc6CZUGLzSjwrAY0 false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P0C6X7-PRO_0000037319 uniprotkb:Q92802 intact:EBI-25487926 intact:EBI-2514973|uniprotkb:A3KME8|ensembl:ENSP00000267068|ensembl:ENSP00000501416|ensembl:ENSP00000501516|ensembl:ENSP00000501518|ensembl:ENSP00000501537 psi-mi:p0c6x7-pro_0000037319(display_long)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)|uniprotkb:rep(gene name)|psi-mi:rep(display_short) psi-mi:n42l2_human(display_long)|uniprotkb:N4BP2L2(gene name)|psi-mi:N4BP2L2(display_short)|uniprotkb:CG005(gene name synonym)|uniprotkb:PFAAP5(gene name synonym)|uniprotkb:Phosphonoformate immuno-associated protein 5(gene name synonym) psi-mi:"MI:0398"(two hybrid pooling approach) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25488637|imex:IM-27830-22 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:P0C6X7(chain-parent)|intact:EBI-7843867(chain-parent) refseq:XP_016875836.1|refseq:XP_016875837.1|refseq:XP_016875838.1|refseq:NP_055702.1|ensembl:ENSG00000244754(gene)|ensembl:ENST00000267068(transcript)|ensembl:ENST00000674349(transcript)|ensembl:ENST00000674421(transcript)|ensembl:ENST00000674465(transcript)|ensembl:ENST00000674484(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001824"(blastocyst development)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019899"(enzyme binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1902035"(positive regulation of hematopoietic stem cell proliferation)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|interpro:IPR026302|interpro:IPR026568|interpro:IPR027417|mint:Q92802 - chain-seq-start:5302|chain-seq-end:5902 - figure legend:ST1|comment:"Library for Y2H screening used: brain"|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/19 2020/03/31 rogid:p7KzZyyr+yMS7ZiMTBx4VVZRzGc694009 rogid:a7wRNCzoB/ImcDT7U8E5355qX1A9606 rigid:NYpXL4nle0Qkb0ocmUSB+wvANPI false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P0C6X7-PRO_0000037320 uniprotkb:P05155 intact:EBI-25487328 intact:EBI-1223454|uniprotkb:Q547W3|uniprotkb:Q59EI5|uniprotkb:Q96FE0|uniprotkb:A6NMU0|uniprotkb:A8KAI9|uniprotkb:B2R6L5|uniprotkb:Q16304|uniprotkb:Q7Z455|uniprotkb:Q9UC49|uniprotkb:Q9UCF9|uniprotkb:B4E1F0|uniprotkb:B4E1H2|ensembl:ENSP00000278407|ensembl:ENSP00000504807 psi-mi:p0c6x7-pro_0000037320(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:ic1_human(display_long)|uniprotkb:SERPING1(gene name)|psi-mi:SERPING1(display_short)|uniprotkb:C1IN(gene name synonym)|uniprotkb:C1NH(gene name synonym)|uniprotkb:C1 esterase inhibitor(gene name synonym)|uniprotkb:C1-inhibiting factor(gene name synonym)|uniprotkb:Serpin G1(gene name synonym) psi-mi:"MI:0398"(two hybrid pooling approach) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25488644|imex:IM-27830-84 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7843867(chain-parent)|uniprotkb:P0C6X7(chain-parent) refseq:NP_000053.2|refseq:NP_001027466.1|dip:DIP-45635N|ensembl:ENSG00000149131(gene)|ensembl:ENST00000278407(transcript)|ensembl:ENST00000676670(transcript)|go:"GO:0001869"(negative regulation of complement activation, lectin pathway)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0007568"(aging)|go:"GO:0007596"(blood coagulation)|go:"GO:0008015"(blood circulation)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0042730"(fibrinolysis)|go:"GO:0045087"(innate immune response)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR015553(Protease inhibitor I4, serpin C1)|interpro:IPR023795|interpro:IPR023796|interpro:IPR036186|interpro:IPR042178|interpro:IPR042185|mint:P05155|rcsb pdb:1M6Q|rcsb pdb:2OAY|rcsb pdb:5DU3|rcsb pdb:5DUQ|rcsb pdb:7AKV|reactome:R-HSA-114608|reactome:R-HSA-140837|reactome:R-HSA-9657689|reactome:R-HSA-977606 - chain-seq-start:5903|chain-seq-end:6429 - figure legend:ST1|comment:"Library for Y2H screening used: brain"|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/19 2020/03/31 rogid:FPQjk4Qo6mt2gs5v5hPwe+xPyrI694009 rogid:Y7cqCZ6Ryz51dsi6jM86EXdfeWc9606 rigid:9Adv4BUm55tEsTINX2PO/mIjR7U false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P0C6X7-PRO_0000037320 uniprotkb:Q13561 intact:EBI-25487328 intact:EBI-715074|uniprotkb:Q86YN2|uniprotkb:Q9BW17|uniprotkb:B2RBK5|ensembl:ENSP00000447824 psi-mi:p0c6x7-pro_0000037320(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:dctn2_human(display_long)|uniprotkb:Dynactin complex 50 kDa subunit(gene name synonym)|uniprotkb:50 kDa dynein-associated polypeptide(gene name synonym)|uniprotkb:p50 dynamitin(gene name synonym)|uniprotkb:DCTN2(gene name)|psi-mi:DCTN2(display_short)|uniprotkb:DCTN50(gene name synonym) psi-mi:"MI:0398"(two hybrid pooling approach) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25488651|imex:IM-27830-102 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7843867(chain-parent)|uniprotkb:P0C6X7(chain-parent) refseq:NP_006391.1|refseq:NP_001248341.1|refseq:NP_001248342.1|dip:DIP-37545N|reactome:R-HSA-2565942|reactome:R-HSA-3371497|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-6807878|reactome:R-HSA-6811436|reactome:R-HSA-8854518|ensembl:ENSG00000175203(gene)|ensembl:ENST00000548249(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005869"(dynactin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030286"(dynein complex)|go:"GO:0030426"(growth cone)|go:"GO:0030507"(spectrin binding)|go:"GO:0031982"(vesicle)|go:"GO:0032402"(melanosome transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071539"(protein localization to centrosome)|interpro:IPR028133|mint:Q13561|reactome:R-HSA-2132295 - chain-seq-start:5903|chain-seq-end:6429 - figure legend:ST1|comment:"Library for Y2H screening used: fetal brain"|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/19 2020/03/31 rogid:FPQjk4Qo6mt2gs5v5hPwe+xPyrI694009 rogid:JrL5jUtArek+zqmCkPKomnjuSf09606 rigid:oCv+sPCGMsaB+987F9X7qrsD0is false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P0C6X7-PRO_0000037321 uniprotkb:P62937 intact:EBI-25487301 intact:EBI-437708|uniprotkb:P05092|uniprotkb:Q3KQW3|uniprotkb:Q6IBU5|uniprotkb:Q96IX3|uniprotkb:Q9BRU4|uniprotkb:Q9BTY9|uniprotkb:Q9UC61|uniprotkb:Q567Q0|ensembl:ENSP00000419425|uniprotkb:A8K220 psi-mi:p0c6x7-pro_0000037321(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:ppia_human(display_long)|uniprotkb:Cyclophilin A(gene name synonym)|uniprotkb:Cyclosporin A-binding protein(gene name synonym)|uniprotkb:PPIA(gene name)|psi-mi:PPIA(display_short)|uniprotkb:CYPA(gene name synonym)|uniprotkb:Rotamase A(gene name synonym) psi-mi:"MI:0398"(two hybrid pooling approach) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25488658|imex:IM-27830-226 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7843867(chain-parent)|uniprotkb:P0C6X7(chain-parent) refseq:NP_066953.1|interpro:IPR029000|mint:P62937|rcsb pdb:1AK4|rcsb pdb:1AWQ|rcsb pdb:1AWR|rcsb pdb:1AWS|rcsb pdb:1AWT|rcsb pdb:1AWU|rcsb pdb:1AWV|rcsb pdb:1BCK|rcsb pdb:1CWA|rcsb pdb:1CWB|rcsb pdb:1CWC|rcsb pdb:1CWF|rcsb pdb:1CWH|rcsb pdb:1CWI|rcsb pdb:1CWJ|rcsb pdb:1CWK|rcsb pdb:1CWL|rcsb pdb:1CWM|interpro:IPR024936|rcsb pdb:1CWO|rcsb pdb:1FGL|rcsb pdb:2N0T|rcsb pdb:2RMA|rcsb pdb:1M63|rcsb pdb:2RMB|rcsb pdb:2X25|rcsb pdb:2X2A|rcsb pdb:2X2C|rcsb pdb:2X2D|rcsb pdb:1M9C|rcsb pdb:1M9D|rcsb pdb:1M9E|rcsb pdb:2XGY|rcsb pdb:3CYH|rcsb pdb:3CYS|rcsb pdb:3K0M|rcsb pdb:3K0N|rcsb pdb:3K0O|rcsb pdb:3K0P|rcsb pdb:3K0Q|rcsb pdb:3K0R|rcsb pdb:3ODI|rcsb pdb:3ODL|rcsb pdb:1M9F|rcsb pdb:3RDD|rcsb pdb:1M9X|rcsb pdb:1M9Y|rcsb pdb:4CYH|rcsb pdb:4IPZ|rcsb pdb:4N1M|rcsb pdb:4N1N|rcsb pdb:1MF8|rcsb pdb:4N1O|rcsb pdb:4N1P|rcsb pdb:4N1Q|rcsb pdb:1MIK|rcsb pdb:1NMK|rcsb pdb:1OCA|rcsb pdb:1RMH|rcsb pdb:1VBS|rcsb pdb:1VBT|rcsb pdb:1W8L|rcsb pdb:1W8M|rcsb pdb:1W8V|rcsb pdb:1YND|rcsb pdb:1ZKF|rcsb pdb:2ALF|rcsb pdb:2CPL|rcsb pdb:2CYH|rcsb pdb:2MS4|rcsb pdb:2MZU|rcsb pdb:4N1R|rcsb pdb:4N1S|rcsb pdb:4YUG|rcsb pdb:4YUH|refseq:NP_001287910.1|reactome:R-HSA-210991|reactome:R-HSA-6798695|reactome:R-HSA-8950505|reactome:R-HSA-2025928|ensembl:ENSG00000196262(gene)|ensembl:ENST00000468812(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006457"(protein folding)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006915"(apoptotic process)|go:"GO:0016018"(cyclosporin A binding)|go:"GO:0016020"(membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0030168"(platelet activation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031982"(vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032873"(negative regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034389"(lipid droplet organization)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045069"(regulation of viral genome replication)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046790"(virion binding)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060352"(cell adhesion molecule production)|go:"GO:0061944"(negative regulation of protein K48-linked ubiquitination)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903901"(negative regulation of viral life cycle)|go:"GO:1904399"(heparan sulfate binding)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2001233"(regulation of apoptotic signaling pathway)|interpro:IPR002130(Peptidyl-prolyl cis-trans isomerase, cyclophilin-type)|interpro:IPR020892|go:"GO:0005178"(integrin binding)|rcsb pdb:4YUI|rcsb pdb:4YUJ|rcsb pdb:4YUK|rcsb pdb:4YUL|rcsb pdb:4YUM|rcsb pdb:4YUN|rcsb pdb:4YUO|rcsb pdb:4YUP|rcsb pdb:5CYH|rcsb pdb:5F66|rcsb pdb:5FJB|rcsb pdb:5KUL|rcsb pdb:5KUN|rcsb pdb:5KUO|rcsb pdb:5KUQ|rcsb pdb:5KUR|rcsb pdb:5KUS|rcsb pdb:5KUU|rcsb pdb:5KUV|rcsb pdb:5KUW|rcsb pdb:5KUZ|rcsb pdb:5KV0|rcsb pdb:5KV1|rcsb pdb:5KV2|rcsb pdb:5KV3|rcsb pdb:5KV4|rcsb pdb:5KV5|rcsb pdb:5KV6|rcsb pdb:5KV7|rcsb pdb:5LUD|rcsb pdb:5NOQ|rcsb pdb:5NOR|rcsb pdb:5NOT|rcsb pdb:5NOU|rcsb pdb:5NOV|rcsb pdb:5NOW|rcsb pdb:5NOX|rcsb pdb:5NOY|rcsb pdb:5NOZ|rcsb pdb:5T9U|rcsb pdb:5T9W|rcsb pdb:5T9Z|rcsb pdb:5TA2|rcsb pdb:5TA4|rcsb pdb:5WC7|rcsb pdb:6BTA|rcsb pdb:6GJI|rcsb pdb:6GJJ|rcsb pdb:6GJL|rcsb pdb:6GJM|rcsb pdb:6GJN|rcsb pdb:6GJP|rcsb pdb:6GJR|rcsb pdb:6GJY|rcsb pdb:6GS6|rcsb pdb:6I42|rcsb pdb:6U5C|rcsb pdb:6U5D|rcsb pdb:6U5E|rcsb pdb:6U5G|rcsb pdb:6X3R|rcsb pdb:6X3Y|rcsb pdb:5NOS|rcsb pdb:6X4N|rcsb pdb:6X4O|rcsb pdb:6X4P|rcsb pdb:6X4Q|rcsb pdb:6Y9V|rcsb pdb:6Y9W|rcsb pdb:6Y9X|rcsb pdb:6Y9Y|rcsb pdb:6Y9Z|rcsb pdb:6ZDJ|rcsb pdb:7ABT|reactome:R-HSA-114608|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-173107|rcsb pdb:6X4M|reactome:R-HSA-175474|reactome:R-HSA-180689|dip:DIP-6080N - chain-seq-start:6430|chain-seq-end:6775 - figure legend:ST1|comment:"Library for Y2H screening used: fetal brain"|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/19 2020/03/31 rogid:2/KeRA/+BMPlzdh567VMVEXj9Tc694009 rogid:dr4EVxcO+sqTPBqsQcydRn+rHoo9606 rigid:yqfNMlJcDOZ+SLPPsbqQ2x9tkYc false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P0C6X7-PRO_0000037310 uniprotkb:Q8WXF8 intact:EBI-25474098 intact:EBI-5278558|uniprotkb:Q8NBR2|uniprotkb:Q8NES1|uniprotkb:Q8TAA8|uniprotkb:Q96D35|ensembl:ENSP00000470082|ensembl:ENSP00000471512 psi-mi:p0c6x7-pro_0000037310(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:dedd2_human(display_long)|uniprotkb:DEDD2(gene name)|psi-mi:DEDD2(display_short)|uniprotkb:FLAME3(gene name synonym)|uniprotkb:DED-containing protein FLAME-3(gene name synonym)|uniprotkb:FADD-like anti-apoptotic molecule 3(gene name synonym)|uniprotkb:PSEC0004(orf name) psi-mi:"MI:0398"(two hybrid pooling approach) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25488665|imex:IM-27830-162 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7843867(chain-parent)|uniprotkb:P0C6X7(chain-parent) refseq:NP_579874.1|refseq:NP_001257543.1|refseq:NP_001257544.1|ensembl:ENSG00000160570(gene)|ensembl:ENST00000595337(transcript)|ensembl:ENST00000596251(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006396"(RNA processing)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0016075"(rRNA catabolic process)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030262"(apoptotic nuclear changes)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001875(Death effector)|interpro:IPR011029(DEATH-like)|interpro:IPR038856|mint:Q8WXF8 - chain-seq-start:181|chain-seq-end:818 - figure legend:ST1|comment:"Library for Y2H screening used: brain"|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/19 2020/03/31 rogid:uSbjRz4rkYk4xCxFNKoeNwrWAcQ694009 rogid:KEvs0YThfzCArmJwoQF/bHHttZk9606 rigid:JWhVlmbHhxceVfY37zudbBMq7Fk false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P0C6X7-PRO_0000037310 uniprotkb:P05155 intact:EBI-25474098 intact:EBI-1223454|uniprotkb:Q547W3|uniprotkb:Q59EI5|uniprotkb:Q96FE0|uniprotkb:A6NMU0|uniprotkb:A8KAI9|uniprotkb:B2R6L5|uniprotkb:Q16304|uniprotkb:Q7Z455|uniprotkb:Q9UC49|uniprotkb:Q9UCF9|uniprotkb:B4E1F0|uniprotkb:B4E1H2|ensembl:ENSP00000278407|ensembl:ENSP00000504807 psi-mi:p0c6x7-pro_0000037310(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:ic1_human(display_long)|uniprotkb:SERPING1(gene name)|psi-mi:SERPING1(display_short)|uniprotkb:C1IN(gene name synonym)|uniprotkb:C1NH(gene name synonym)|uniprotkb:C1 esterase inhibitor(gene name synonym)|uniprotkb:C1-inhibiting factor(gene name synonym)|uniprotkb:Serpin G1(gene name synonym) psi-mi:"MI:0398"(two hybrid pooling approach) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25488672|imex:IM-27830-164 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7843867(chain-parent)|uniprotkb:P0C6X7(chain-parent) refseq:NP_000053.2|refseq:NP_001027466.1|dip:DIP-45635N|ensembl:ENSG00000149131(gene)|ensembl:ENST00000278407(transcript)|ensembl:ENST00000676670(transcript)|go:"GO:0001869"(negative regulation of complement activation, lectin pathway)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0007568"(aging)|go:"GO:0007596"(blood coagulation)|go:"GO:0008015"(blood circulation)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0042730"(fibrinolysis)|go:"GO:0045087"(innate immune response)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR015553(Protease inhibitor I4, serpin C1)|interpro:IPR023795|interpro:IPR023796|interpro:IPR036186|interpro:IPR042178|interpro:IPR042185|mint:P05155|rcsb pdb:1M6Q|rcsb pdb:2OAY|rcsb pdb:5DU3|rcsb pdb:5DUQ|rcsb pdb:7AKV|reactome:R-HSA-114608|reactome:R-HSA-140837|reactome:R-HSA-9657689|reactome:R-HSA-977606 - chain-seq-start:181|chain-seq-end:818 - figure legend:ST1|comment:"Library for Y2H screening used: brain"|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/19 2020/03/31 rogid:uSbjRz4rkYk4xCxFNKoeNwrWAcQ694009 rogid:Y7cqCZ6Ryz51dsi6jM86EXdfeWc9606 rigid:M4R1mQKE2oCszukofYHiIj28ys4 false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P0C6X7-PRO_0000037311 uniprotkb:Q9H000 intact:EBI-25474079 intact:EBI-2341005|uniprotkb:A6NIA2|uniprotkb:Q9BUY2|uniprotkb:B3KRC5|uniprotkb:Q96BD4|uniprotkb:Q8N391|uniprotkb:Q9NRY1|uniprotkb:B4DPR4|intact:EBI-11126681|ensembl:ENSP00000170447|ensembl:ENSP00000502893 psi-mi:p0c6x7-pro_0000037311(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:mkrn2_human(display_long)|uniprotkb:MKRN2(gene name)|psi-mi:MKRN2(display_short)|uniprotkb:RNF62(gene name synonym)|uniprotkb:RING finger protein 62(gene name synonym)|uniprotkb:HSPC070(orf name)|uniprotkb:RING-type E3 ubiquitin transferase makorin-2(gene name synonym) psi-mi:"MI:0398"(two hybrid pooling approach) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25488693|imex:IM-27830-104 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7843867(chain-parent) refseq:NP_054879.3|refseq:NP_001258636.1|ensembl:ENSG00000075975(gene)|ensembl:ENST00000170447(transcript)|ensembl:ENST00000677816(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000571(Zinc finger, CCCH-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR026293|interpro:IPR036855|interpro:IPR041367|mint:Q9H000 - chain-seq-start:819|chain-seq-end:2740 - figure legend:ST1|comment:"Library for Y2H screening used: ORFeome, brain, fetal brain"|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/19 2020/03/31 rogid:NKZ5d0D2HjefhmJQwgHz+M1lSt8694009 rogid:ZI7Jr4Fd52sQnfeNXXcZ0NscyD89606 rigid:WE6wZJV6nmECUnNEQbdgMZi3mmY false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P0C6X7-PRO_0000037310 uniprotkb:Q7Z3Q1 intact:EBI-25474098 intact:EBI-25456815|ensembl:ENSP00000266943|uniprotkb:Q3ZCV8|uniprotkb:Q6NUK5|uniprotkb:Q6P9B3|uniprotkb:Q6ZVG5|uniprotkb:Q96QA1 psi-mi:p0c6x7-pro_0000037310(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:s46a3_human(display_long)|uniprotkb:SLC46A3(gene name)|psi-mi:SLC46A3(display_short)|uniprotkb:FKSG16(orf name) psi-mi:"MI:0398"(two hybrid pooling approach) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25488686|imex:IM-27830-24 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7843867(chain-parent)|uniprotkb:P0C6X7(chain-parent) ensembl:ENSG00000139508(gene)|ensembl:ENST00000266943(transcript)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0034486"(vacuolar transmembrane transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:1905103"(integral component of lysosomal membrane)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR036259|refseq:NP_001129391.1|refseq:NP_001334889.1|refseq:NP_861450.1|refseq:XP_005266418.1 - chain-seq-start:181|chain-seq-end:818 - figure legend:ST1|comment:"Library for Y2H screening used: brain"|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/19 2020/03/31 rogid:uSbjRz4rkYk4xCxFNKoeNwrWAcQ694009 rogid:tqBPVBSR2iLOkOQvSQg/KwI2Baw9606 rigid:seaBtOl9r7l0sXBNKpSM8zX+UxA false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P0C6X7-PRO_0000037310 uniprotkb:Q7Z494 intact:EBI-25474098 intact:EBI-2804263|uniprotkb:Q68D99|uniprotkb:Q8NCM5|uniprotkb:Q7Z493|uniprotkb:Q5JPE3|uniprotkb:Q96NK2|uniprotkb:Q5JPE6|uniprotkb:Q6NVH3|uniprotkb:Q96N70|uniprotkb:Q7Z492|uniprotkb:Q8N9R2|ensembl:ENSP00000338766 psi-mi:p0c6x7-pro_0000037310(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:nphp3_human(display_long)|uniprotkb:KIAA2000(gene name synonym)|uniprotkb:NPHP3(gene name)|psi-mi:NPHP3(display_short) psi-mi:"MI:0398"(two hybrid pooling approach) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25488679|imex:IM-27830-46 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7843867(chain-parent)|uniprotkb:P0C6X7(chain-parent) refseq:NP_694972.3|ensembl:ENSG00000113971(gene)|ensembl:ENST00000337331(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001947"(heart looping)|go:"GO:0003283"(atrial septum development)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030324"(lung development)|go:"GO:0035469"(determination of pancreatic left/right asymmetry)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048496"(maintenance of animal organ identity)|go:"GO:0060027"(convergent extension involved in gastrulation)|go:"GO:0060271"(cilium assembly)|go:"GO:0060287"(epithelial cilium movement involved in determination of left/right asymmetry)|go:"GO:0060993"(kidney morphogenesis)|go:"GO:0071908"(determination of intestine left/right asymmetry)|go:"GO:0071909"(determination of stomach left/right asymmetry)|go:"GO:0071910"(determination of liver left/right asymmetry)|go:"GO:0072189"(ureter development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:2000095"(regulation of Wnt signaling pathway, planar cell polarity pathway)|go:"GO:2000167"(regulation of planar cell polarity pathway involved in neural tube closure)|rcsb pdb:5L7K|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR027417|reactome:R-HSA-5624138 - chain-seq-start:181|chain-seq-end:818 - figure legend:ST1|comment:"Library for Y2H screening used: brain"|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/19 2020/03/31 rogid:uSbjRz4rkYk4xCxFNKoeNwrWAcQ694009 rogid:7SitCJ9bwhu4VXh9FjX/wWCq0UQ9606 rigid:CVGbCxelLi60aahTwiIgi8PBKmU false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P0C6X7-PRO_0000037314 uniprotkb:Q13564 intact:EBI-25487672 intact:EBI-718631|uniprotkb:A6NFN4|uniprotkb:B2R700|uniprotkb:A6NCK0|uniprotkb:A8MU28|uniprotkb:B3KUP9|ensembl:ENSP00000290810 psi-mi:p0c6x7-pro_0000037314(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:ula1_human(display_long)|uniprotkb:APPBP1(gene name synonym)|uniprotkb:Amyloid protein-binding protein 1(gene name synonym)|uniprotkb:Amyloid beta precursor protein-binding protein 1, 59 kDa(gene name synonym)|uniprotkb:Proto-oncogene protein 1(gene name synonym)|uniprotkb:NAE1(gene name)|psi-mi:NAE1(display_short)|uniprotkb:HPP1(orf name) psi-mi:"MI:0398"(two hybrid pooling approach) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25488825|imex:IM-27830-50 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7843867(chain-parent)|uniprotkb:P0C6X7(chain-parent) refseq:NP_001273429.1|refseq:NP_001018169.1|refseq:NP_001018170.1|refseq:NP_003896.1|refseq:XP_011521724.1|refseq:XP_005256272.1|ensembl:ENSG00000159593(gene)|ensembl:ENST00000290810(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0019781"(NEDD8 activating enzyme activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0045116"(protein neddylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051402"(neuron apoptotic process)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR030667|interpro:IPR035985|mint:Q13564|rcsb pdb:1R4M|rcsb pdb:1R4N|rcsb pdb:1TT5|rcsb pdb:1YOV|rcsb pdb:2NVU|rcsb pdb:3DBH|rcsb pdb:3DBL|rcsb pdb:3DBR|rcsb pdb:3GZN|reactome:R-HSA-8951664 - chain-seq-start:3837|chain-seq-end:3919 - figure legend:ST1|comment:"Library for Y2H screening used: fetal brain"|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/19 2020/03/31 rogid:95nEGuIgfxXAK4CVWXC+sH1eT+c694009 rogid:IPyDtfN10ZJIeQatu2Z/SwskHXk9606 rigid:Oht//GmuETo5jIe16OW2APbxOz4 false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P0C6X7-PRO_0000037314 uniprotkb:A9UHW6 intact:EBI-25487672 intact:EBI-373498|uniprotkb:Q8N4Q5|intact:EBI-946774|uniprotkb:B4DUM7|uniprotkb:Q9HBL5|ensembl:ENSP00000321625|ensembl:ENSP00000484245 psi-mi:p0c6x7-pro_0000037314(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:mi4gd_human(display_long)|uniprotkb:SLIP1(gene name synonym)|uniprotkb:SLBP-interacting protein 1(gene name synonym)|uniprotkb:MIF4GD(gene name)|psi-mi:MIF4GD(display_short) psi-mi:"MI:0398"(two hybrid pooling approach) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25488818|imex:IM-27830-200 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7843867(chain-parent)|uniprotkb:P0C6X7(chain-parent) ensembl:ENSG00000125457(gene)|ensembl:ENST00000325102(transcript)|ensembl:ENST00000618645(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008494"(translation activator activity)|go:"GO:0042802"(identical protein binding)|interpro:IPR003890(MIF4G-like, type 3)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|mint:A9UHW6|refseq:NP_001229427.1|refseq:NP_001229429.1|refseq:NP_001229430.1|refseq:NP_065730.2|refseq:XP_005257589.1|refseq:XP_005257590.1|refseq:XP_016880382.1|refseq:XP_016880383.1|refseq:XP_005257587.1 - chain-seq-start:3837|chain-seq-end:3919 - figure legend:ST1|comment:"Library for Y2H screening used: fetal brain"|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/19 2020/03/31 rogid:95nEGuIgfxXAK4CVWXC+sH1eT+c694009 rogid:fVJrdaWCxDp4EBdc1QyA0lECSGE9606 rigid:cH2SCpClB7KEDbxSVGddxa/RQ0U false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P0C6X7-PRO_0000037314 uniprotkb:P62258 intact:EBI-25487672 intact:EBI-356498|uniprotkb:P29360|uniprotkb:P42655|uniprotkb:Q53XZ5|uniprotkb:Q63631|uniprotkb:Q7M4R4|uniprotkb:B3KY71|uniprotkb:D3DTH5|uniprotkb:Q4VJB6|ensembl:ENSP00000264335|ensembl:ENSP00000487356 psi-mi:p0c6x7-pro_0000037314(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:1433e_human(display_long)|uniprotkb:YWHAE(gene name)|psi-mi:YWHAE(display_short) psi-mi:"MI:0398"(two hybrid pooling approach) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25488811|imex:IM-27830-108 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7843867(chain-parent)|uniprotkb:P0C6X7(chain-parent) refseq:NP_006752.1|dip:DIP-36676N|reactome:R-HSA-1445148|reactome:R-HSA-2028269|reactome:R-HSA-205025|reactome:R-HSA-2565942|reactome:R-HSA-3371453|reactome:R-HSA-3371511|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-5625740|reactome:R-HSA-5628897|reactome:R-HSA-75035|reactome:R-HSA-8854518|reactome:R-HSA-8862803|reactome:R-HSA-8876198|ensembl:ENSG00000108953(gene)|ensembl:ENSG00000274474(gene)|ensembl:ENST00000264335(transcript)|ensembl:ENST00000627231(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0003064"(regulation of heart rate by hormone)|go:"GO:0003723"(RNA binding)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005925"(focal adhesion)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0060306"(regulation of membrane repolarization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0086013"(membrane repolarization during cardiac muscle cell action potential)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0090724"(central region of growth cone)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|go:"GO:1901020"(negative regulation of calcium ion transmembrane transporter activity)|go:"GO:1902309"(negative regulation of peptidyl-serine dephosphorylation)|go:"GO:1905913"(negative regulation of calcium ion export across plasma membrane)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P62258|rcsb pdb:2BR9|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6EIH|rcsb pdb:7C8E|reactome:R-HSA-111447 - chain-seq-start:3837|chain-seq-end:3919 - figure legend:ST1|comment:"Library for Y2H screening used: fetal brain"|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/19 2020/03/31 rogid:95nEGuIgfxXAK4CVWXC+sH1eT+c694009 rogid:mnuAjdnQZbMFojll2PnV3xFklXQ9606 rigid:ugALA48BImcT4pPtgQhx1pAGD2M false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P0C6X7-PRO_0000037314 uniprotkb:Q9HCD5 intact:EBI-25487672 intact:EBI-2863498|uniprotkb:Q9H1F2|uniprotkb:Q6HA99|uniprotkb:Q9H2T2|uniprotkb:B2RTV9|uniprotkb:Q9H4Y9|uniprotkb:E1P5R0|ensembl:ENSP00000290231 psi-mi:p0c6x7-pro_0000037314(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:ncoa5_human(display_long)|uniprotkb:NCOA5(gene name)|psi-mi:NCOA5(display_short)|uniprotkb:KIAA1637(gene name synonym)|uniprotkb:Coactivator independent of AF-2(gene name synonym) psi-mi:"MI:0398"(two hybrid pooling approach) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25488804|imex:IM-27830-106 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7843867(chain-parent)|uniprotkb:P0C6X7(chain-parent) refseq:NP_066018.1|ensembl:ENSG00000124160(gene)|ensembl:ENST00000290231(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|interpro:IPR036621|mint:Q9HCD5|rcsb pdb:1V95|rcsb pdb:2J7X|rcsb pdb:2J7Y|rcsb pdb:4ZI1 - chain-seq-start:3837|chain-seq-end:3919 - figure legend:ST1|comment:"Library for Y2H screening used: fetal brain"|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/19 2020/03/31 rogid:95nEGuIgfxXAK4CVWXC+sH1eT+c694009 rogid:OxiZZWrvRqepYlZiuTR4RqZWn1A9606 rigid:LXHuXwuHM5IgAq10LiGeVYnHqOw false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P0C6X7-PRO_0000037314 uniprotkb:P49703 intact:EBI-25487672 intact:EBI-711726|uniprotkb:D3DX43|uniprotkb:B2RC59|ensembl:ENSP00000322628 psi-mi:p0c6x7-pro_0000037314(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:arl4d_human(display_long)|uniprotkb:ADP-ribosylation factor-like protein 4L(gene name synonym)|uniprotkb:ARL4D(gene name)|psi-mi:ARL4D(display_short)|uniprotkb:ARF4L(gene name synonym) psi-mi:"MI:0398"(two hybrid pooling approach) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25488797|imex:IM-27830-232 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7843867(chain-parent)|uniprotkb:P0C6X7(chain-parent) refseq:XP_011523084.1|refseq:NP_001652.2|ensembl:ENSG00000175906(gene)|ensembl:ENST00000320033(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0009306"(protein secretion)|go:"GO:0016192"(vesicle-mediated transport)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR027417 - chain-seq-start:3837|chain-seq-end:3919 - figure legend:ST1|comment:"Library for Y2H screening used: brain, fetal brain"|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/19 2020/03/31 rogid:95nEGuIgfxXAK4CVWXC+sH1eT+c694009 rogid:WwIcO01lqYPLpEG0IND+daoFayE9606 rigid:+Fqp7eU7UB7gpoC2pKE1IyvC1yo false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q92560 uniprotkb:P0C6X7-PRO_0000037314 intact:EBI-1791447|uniprotkb:Q6LEM0|uniprotkb:Q7Z5E8|uniprotkb:A8K993|intact:EBI-2558090|ensembl:ENSP00000417132 intact:EBI-25487672 psi-mi:bap1_human(display_long)|uniprotkb:BAP1(gene name)|psi-mi:BAP1(display_short)|uniprotkb:KIAA0272(gene name synonym)|uniprotkb:hucep-6(orf name)|uniprotkb:BRCA1-associated protein 1(gene name synonym)|uniprotkb:Cerebral protein 6(gene name synonym) psi-mi:p0c6x7-pro_0000037314(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:"MI:0398"(two hybrid pooling approach) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25488790|imex:IM-27830-168 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-47004N|refseq:NP_004647.1|ensembl:ENSG00000163930(gene)|ensembl:ENST00000460680(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0003682"(chromatin binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010035"(response to inorganic substance)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035517"(PR-DUB complex)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035522"(monoubiquitinated histone H2A deubiquitination)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061519"(macrophage homeostasis)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR001578(Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1)|interpro:IPR036959|interpro:IPR038765|interpro:IPR041507|mint:Q92560|reactome:R-HSA-5689603|reactome:R-HSA-5693565 intact:EBI-7843867(chain-parent)|uniprotkb:P0C6X7(chain-parent) - - chain-seq-start:3837|chain-seq-end:3919 figure legend:ST1|comment:"Library for Y2H screening used: fetal brain"|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/19 2020/03/31 rogid:GMWdT1u5HUl29N+YgC/bCKTbxm49606 rogid:95nEGuIgfxXAK4CVWXC+sH1eT+c694009 rigid:15Q8abih0P9Tv6hv/zhizP7j4M0 false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P0C6X7-PRO_0000037314 uniprotkb:Q8TEB7 intact:EBI-25487672 intact:EBI-2341619|uniprotkb:Q6ZTJ8|uniprotkb:Q9H5E4|uniprotkb:Q96RF3|uniprotkb:Q6PH80|uniprotkb:A0PJI4|ensembl:ENSP00000255499 psi-mi:p0c6x7-pro_0000037314(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:rn128_human(display_long)|uniprotkb:RNF128(gene name)|psi-mi:RNF128(display_short)|uniprotkb:RING finger protein 128(gene name synonym)|uniprotkb:Gene related to anergy in lymphocytes protein(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF128(gene name synonym) psi-mi:"MI:0398"(two hybrid pooling approach) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25488783|imex:IM-27830-122 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7843867(chain-parent)|uniprotkb:P0C6X7(chain-parent) refseq:NP_078815.3|refseq:NP_919445.1|ensembl:ENSG00000133135(gene)|ensembl:ENST00000255499(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005737"(cytoplasm)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1904352"(positive regulation of protein catabolic process in the vacuole)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003137(Protease-associated PA)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|rcsb pdb:3ICU|reactome:R-HSA-5689880|reactome:R-HSA-5689896 - chain-seq-start:3837|chain-seq-end:3919 - figure legend:ST1|comment:"Library for Y2H screening used: fetal brain"|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/19 2020/03/31 rogid:95nEGuIgfxXAK4CVWXC+sH1eT+c694009 rogid:rHG5hoB/R1yW2BDsMr7LJEAXAWw9606 rigid:MyHkVKZd6ALZy3UB01Tteo1MTiY false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P0C6X7-PRO_0000037314 uniprotkb:O95865 intact:EBI-25487672 intact:EBI-749139|uniprotkb:A2BEZ7|ensembl:ENSP00000364943|ensembl:ENSP00000364945|ensembl:ENSP00000364949|ensembl:ENSP00000372901|ensembl:ENSP00000382935|ensembl:ENSP00000389552|ensembl:ENSP00000391632|ensembl:ENSP00000391833|ensembl:ENSP00000395372|ensembl:ENSP00000395759|ensembl:ENSP00000397466|ensembl:ENSP00000399023|ensembl:ENSP00000399357|ensembl:ENSP00000402594|ensembl:ENSP00000403154|ensembl:ENSP00000404342|ensembl:ENSP00000404851|ensembl:ENSP00000405515|ensembl:ENSP00000408148|ensembl:ENSP00000409396|ensembl:ENSP00000412327|ensembl:ENSP00000412800|ensembl:ENSP00000382936 psi-mi:p0c6x7-pro_0000037314(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:ddah2_human(display_long)|uniprotkb:DDAHII(gene name synonym)|uniprotkb:Dimethylargininase-2(gene name synonym)|uniprotkb:S-phase protein(gene name synonym)|uniprotkb:Protein G6a(gene name synonym)|uniprotkb:DDAH2(gene name)|psi-mi:DDAH2(display_short)|uniprotkb:DDAH(gene name synonym)|uniprotkb:G6A(gene name synonym)|uniprotkb:NG30(gene name synonym) psi-mi:"MI:0398"(two hybrid pooling approach) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25488776|imex:IM-27830-198 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7843867(chain-parent)|uniprotkb:P0C6X7(chain-parent) ensembl:ENSG00000206395(gene)|ensembl:ENSG00000213722(gene)|ensembl:ENSG00000225635(gene)|ensembl:ENSG00000226634(gene)|ensembl:ENSG00000227317(gene)|ensembl:ENSG00000228128(gene)|ensembl:ENSG00000233076(gene)|refseq:NP_039268.1|refseq:XP_011512750.1|refseq:NP_001289936.1|refseq:NP_001289937.1|ensembl:ENST00000375787(transcript)|ensembl:ENST00000375789(transcript)|ensembl:ENST00000375792(transcript)|ensembl:ENST00000383409(transcript)|ensembl:ENST00000437889(transcript)|ensembl:ENST00000400062(transcript)|ensembl:ENST00000400063(transcript)|ensembl:ENST00000411456(transcript)|ensembl:ENST00000413532(transcript)|ensembl:ENST00000413655(transcript)|ensembl:ENST00000414455(transcript)|ensembl:ENST00000416410(transcript)|ensembl:ENST00000443533(transcript)|ensembl:ENST00000424790(transcript)|ensembl:ENST00000426149(transcript)|ensembl:ENST00000444699(transcript)|ensembl:ENST00000447101(transcript)|ensembl:ENST00000451411(transcript)|ensembl:ENST00000454138(transcript)|ensembl:ENST00000427126(transcript)|go:"GO:0000052"(citrulline metabolic process)|ensembl:ENST00000430482(transcript)|go:"GO:0003824"(catalytic activity)|go:"GO:0005739"(mitochondrion)|ensembl:ENST00000434464(transcript)|ensembl:ENST00000436437(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006525"(arginine metabolic process)|go:"GO:0006527"(arginine catabolic process)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0016403"(dimethylargininase activity)|go:"GO:0016597"(amino acid binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR033199|interpro:IPR033202|reactome:R-HSA-203615|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process) - chain-seq-start:3837|chain-seq-end:3919 - figure legend:ST1|comment:"Library for Y2H screening used: fetal brain"|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/19 2020/03/31 rogid:95nEGuIgfxXAK4CVWXC+sH1eT+c694009 rogid:u/xau/wTFcLGsICADPBRLQWljkk9606 rigid:lQQLKirTmWSfh2oEAFK2xz8hBfw false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P0C6X7-PRO_0000037313 uniprotkb:O14498 intact:EBI-25487192 intact:EBI-21576829|ensembl:ENSP00000249842|ensembl:ENSP00000378550|ensembl:ENSP00000499984|ensembl:ENSP00000500029 psi-mi:p0c6x7-pro_0000037313(display_long)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)|uniprotkb:rep(gene name)|psi-mi:rep(display_short) psi-mi:islr_human(display_long)|uniprotkb:ISLR(gene name)|psi-mi:ISLR(display_short)|uniprotkb:UNQ189/PRO215(orf name) psi-mi:"MI:0398"(two hybrid pooling approach) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25488769|imex:IM-27830-28 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7843867(chain-parent) refseq:NP_005536.1|refseq:NP_958934.1|ensembl:ENSG00000129009(gene)|ensembl:ENSG00000288508(gene)|ensembl:ENST00000249842(transcript)|ensembl:ENST00000395118(transcript)|ensembl:ENST00000671810(transcript)|ensembl:ENST00000672683(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0007155"(cell adhesion)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR032675|interpro:IPR036179|reactome:R-HSA-114608 - chain-seq-start:3547|chain-seq-end:3836 - figure legend:ST1|comment:"Library for Y2H screening used: brain"|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/19 2020/03/31 rogid:gj8dp2I2Ya5s1l4ssgeZJvDPfVM694009 rogid:vbqLMrYnXCWmG72jkvRkweF9tFs9606 rigid:UD+3k7tYlg2dyOomKyfLF+iQh0s false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P0C6X7-PRO_0000037312 uniprotkb:Q9GZN8 intact:EBI-25487250 intact:EBI-740589|uniprotkb:Q9NWX3|uniprotkb:A8K4J0|uniprotkb:D3DVX8|uniprotkb:Q5JX81|ensembl:ENSP00000369097|ensembl:ENSP00000382580 psi-mi:p0c6x7-pro_0000037312(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:ct027_human(display_long)|uniprotkb:C20orf27(gene name)|psi-mi:C20orf27(display_short) psi-mi:"MI:0398"(two hybrid pooling approach) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25488762|imex:IM-27830-48 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7843867(chain-parent) refseq:NP_001034229.1|refseq:NP_001245358.1|refseq:NP_001245359.1|ensembl:ENSG00000101220(gene)|ensembl:ENST00000379772(transcript)|ensembl:ENST00000399672(transcript)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR026794 - chain-seq-start:3241|chain-seq-end:3546 - figure legend:ST1|comment:"Library for Y2H screening used: fetal brain"|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/19 2020/03/31 rogid:6LbRC/jITHtqNPZLpKst/+pNdOQ694009 rogid:QFVg9gTSKTpE0lI40DuiCwOZPvI9606 rigid:U5q6RjjzXRtUAwkHOjs0IZ/7nhY false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P0C6X7-PRO_0000037312 uniprotkb:P23025 intact:EBI-25487250 intact:EBI-295222|uniprotkb:Q6LCW7|uniprotkb:Q5T1U9|uniprotkb:Q6LD02|ensembl:ENSP00000364270 psi-mi:p0c6x7-pro_0000037312(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:xpa_human(display_long)|uniprotkb:XPA(gene name)|psi-mi:XPA(display_short)|uniprotkb:XPAC(gene name synonym)|uniprotkb:Xeroderma pigmentosum group A-complementing protein(gene name synonym) psi-mi:"MI:0398"(two hybrid pooling approach) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25488755|imex:IM-27830-166 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7843867(chain-parent) refseq:NP_000371.1|dip:DIP-24191N|ensembl:ENSG00000136936(gene)|ensembl:ENST00000375128(transcript)|go:"GO:0000110"(nucleotide-excision repair factor 1 complex)|go:"GO:0000715"(nucleotide-excision repair, DNA damage recognition)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006284"(base-excision repair)|go:"GO:0009650"(UV protection)|go:"GO:0010996"(response to auditory stimulus)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0033683"(nucleotide-excision repair, DNA incision)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045171"(intercellular bridge)|go:"GO:0046872"(metal ion binding)|go:"GO:0070914"(UV-damage excision repair)|go:"GO:1901255"(nucleotide-excision repair involved in interstrand cross-link repair)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000465(XPA)|interpro:IPR009061(Putative DNA binding)|interpro:IPR022652|interpro:IPR022656|interpro:IPR022658|interpro:IPR037129|mint:P23025|rcsb pdb:1D4U|rcsb pdb:1XPA|rcsb pdb:2JNW|rcsb pdb:6J44|rcsb pdb:6LAE|rcsb pdb:6RO4|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6782135 - chain-seq-start:3241|chain-seq-end:3546 - figure legend:ST1|comment:"Library for Y2H screening used: fetal brain"|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/19 2020/03/31 rogid:6LbRC/jITHtqNPZLpKst/+pNdOQ694009 rogid:pHnq8HVW+SweFUtxsfwUaQcRokE9606 rigid:twrc2d57PIVe5sS5chh4vtHVIu0 false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P0C6X7-PRO_0000037312 uniprotkb:Q92802 intact:EBI-25487250 intact:EBI-2514973|uniprotkb:A3KME8|ensembl:ENSP00000267068|ensembl:ENSP00000501416|ensembl:ENSP00000501516|ensembl:ENSP00000501518|ensembl:ENSP00000501537 psi-mi:p0c6x7-pro_0000037312(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:n42l2_human(display_long)|uniprotkb:N4BP2L2(gene name)|psi-mi:N4BP2L2(display_short)|uniprotkb:CG005(gene name synonym)|uniprotkb:PFAAP5(gene name synonym)|uniprotkb:Phosphonoformate immuno-associated protein 5(gene name synonym) psi-mi:"MI:0398"(two hybrid pooling approach) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25488748|imex:IM-27830-184 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7843867(chain-parent) refseq:XP_016875836.1|refseq:XP_016875837.1|refseq:XP_016875838.1|refseq:NP_055702.1|ensembl:ENSG00000244754(gene)|ensembl:ENST00000267068(transcript)|ensembl:ENST00000674349(transcript)|ensembl:ENST00000674421(transcript)|ensembl:ENST00000674465(transcript)|ensembl:ENST00000674484(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001824"(blastocyst development)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019899"(enzyme binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1902035"(positive regulation of hematopoietic stem cell proliferation)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|interpro:IPR026302|interpro:IPR026568|interpro:IPR027417|mint:Q92802 - chain-seq-start:3241|chain-seq-end:3546 - figure legend:ST1|comment:"Library for Y2H screening used: brain"|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/19 2020/03/31 rogid:6LbRC/jITHtqNPZLpKst/+pNdOQ694009 rogid:a7wRNCzoB/ImcDT7U8E5355qX1A9606 rigid:zA48dYWA+JXvKeH5aup6VLksxBs false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P0C6X7-PRO_0000037312 uniprotkb:P62942 intact:EBI-25487250 intact:EBI-1027571|uniprotkb:P20071|uniprotkb:Q4VC47|uniprotkb:Q6FGD9|uniprotkb:Q6LEU3|uniprotkb:Q9H103|uniprotkb:Q9H566|uniprotkb:D3DVW6|ensembl:ENSP00000371138|ensembl:ENSP00000371143|ensembl:ENSP00000383003|ensembl:ENSP00000503033|ensembl:ENSP00000503152 psi-mi:p0c6x7-pro_0000037312(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:fkb1a_human(display_long)|uniprotkb:FKBP1A(gene name)|psi-mi:FKBP1A(display_short)|uniprotkb:FKBP1(gene name synonym)|uniprotkb:FKBP12(gene name synonym)|uniprotkb:FK506-binding protein 1A(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:Immunophilin FKBP12(gene name synonym)|uniprotkb:12 kDa FK506-binding protein(gene name synonym)|uniprotkb:Calstabin-1(gene name synonym) psi-mi:"MI:0398"(two hybrid pooling approach) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25488741|imex:IM-27830-120 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7843867(chain-parent) ensembl:ENSG00000088832(gene)|ensembl:ENST00000381719(transcript)|ensembl:ENST00000381724(transcript)|ensembl:ENST00000400137(transcript)|ensembl:ENST00000677335(transcript)|ensembl:ENST00000678408(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005527"(macrolide binding)|go:"GO:0005528"(FK506 binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006458"('de novo' protein folding)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0014802"(terminal cisterna)|go:"GO:0016020"(membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0030018"(Z disc)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031312"(extrinsic component of organelle membrane)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032925"(regulation of activin receptor signaling pathway)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0042026"(protein refolding)|go:"GO:0042110"(T cell activation)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0046332"(SMAD binding)|go:"GO:0048185"(activin binding)|go:"GO:0050776"(regulation of immune response)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0060347"(heart trabecula formation)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0098562"(cytoplasmic side of membrane)|go:"GO:1902991"(regulation of amyloid precursor protein catabolic process)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990425"(ryanodine receptor complex)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|rcsb pdb:1A7X|rcsb pdb:1B6C|rcsb pdb:1BKF|rcsb pdb:1BL4|rcsb pdb:1D6O|rcsb pdb:1D7H|rcsb pdb:1D7I|rcsb pdb:1D7J|rcsb pdb:1EYM|rcsb pdb:1F40|rcsb pdb:1FAP|rcsb pdb:1FKB|rcsb pdb:1FKD|rcsb pdb:1FKF|rcsb pdb:1FKG|rcsb pdb:1FKH|rcsb pdb:1FKI|rcsb pdb:2DG4|rcsb pdb:2DG9|rcsb pdb:2FAP|rcsb pdb:2FKE|rcsb pdb:2ND5|rcsb pdb:2PPN|rcsb pdb:2PPO|rcsb pdb:2PPP|rcsb pdb:2RSE|rcsb pdb:3FAP|rcsb pdb:1FKJ|rcsb pdb:3H9R|rcsb pdb:3MDY|rcsb pdb:4DH0|rcsb pdb:4FAP|rcsb pdb:1FKR|rcsb pdb:4IPX|rcsb pdb:4N19|rcsb pdb:4ODP|rcsb pdb:4ODQ|rcsb pdb:4ODR|rcsb pdb:5I7P|rcsb pdb:5I7Q|rcsb pdb:6I1S|rcsb pdb:1FKS|rcsb pdb:6M4U|rcsb pdb:6OQA|rcsb pdb:6VCU|rcsb pdb:6YF0|rcsb pdb:6YF1|rcsb pdb:6YF2|rcsb pdb:6YF3|reactome:R-HSA-166208|rcsb pdb:1FKT|reactome:R-HSA-2025928|reactome:R-HSA-2173789|reactome:R-HSA-2173791|reactome:R-HSA-3656535|rcsb pdb:1J4H|rcsb pdb:1J4I|reactome:R-HSA-9679191|rcsb pdb:1J4R|rcsb pdb:1NSG|rcsb pdb:1QPF|rcsb pdb:1QPL|rcsb pdb:2DG3|refseq:NP_000792.1|refseq:NP_463460.1|dip:DIP-29710N - chain-seq-start:3241|chain-seq-end:3546 - figure legend:ST1|comment:"Library for Y2H screening used: fetal brain"|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/19 2020/03/31 rogid:6LbRC/jITHtqNPZLpKst/+pNdOQ694009 rogid:3eikHNIIVs8AFM7PYVWurI/9KUY9606 rigid:tN0D9V6gTu1mE7225pfgQh4JZNw false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P0C6X7-PRO_0000283841 uniprotkb:Q9Y4W2 intact:EBI-25488721 intact:EBI-1051591|uniprotkb:Q5JXQ0|uniprotkb:Q8TEN5|uniprotkb:Q9H9V5|uniprotkb:A9X410|ensembl:ENSP00000363944 psi-mi:p0c6x7-pro_0000283841(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:las1l_human(display_long)|uniprotkb:LAS1L(gene name)|psi-mi:LAS1L(display_short)|uniprotkb:Protein LAS1 homolog(gene name synonym)|uniprotkb:MSTP060(orf name) psi-mi:"MI:0398"(two hybrid pooling approach) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25488734|imex:IM-27830-230 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:P0C6X7(chain-parent)|intact:EBI-7843867(chain-parent) refseq:NP_001164120.1|refseq:NP_001164121.1|refseq:NP_112483.1|ensembl:ENSG00000001497(gene)|ensembl:ENST00000374811(transcript)|go:"GO:0000460"(maturation of 5.8S rRNA)|go:"GO:0000470"(maturation of LSU-rRNA)|go:"GO:0003723"(RNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0016020"(membrane)|go:"GO:0030687"(preribosome, large subunit precursor)|go:"GO:0071339"(MLL1 complex)|go:"GO:0090730"(Las1 complex)|interpro:IPR007174(Las1-like)|mint:Q9Y4W2|reactome:R-HSA-6791226 - chain-seq-start:2741|chain-seq-end:3240 - figure legend:ST1|comment:"Library for Y2H screening used: fetal brain"|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/19 2020/04/09 rogid:smPAOI1nAWgLZFomtwoLSa1N9vI694009 rogid:1TTE2TCMIwczNaT2SSMLioLkALA9606 rigid:lb6iwH4VePCOCFn9waqHbgy0V0A false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P08949 uniprotkb:P0C6X7-PRO_0000283841 intact:EBI-7964376|intact:MINT-7969962|uniprotkb:Q96HH5|uniprotkb:Q96A06|ensembl:ENSP00000353664 intact:EBI-25488721 psi-mi:nmb_human(display_long)|uniprotkb:NMB(gene name)|psi-mi:NMB(display_short) psi-mi:p0c6x7-pro_0000283841(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:"MI:0398"(two hybrid pooling approach) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25488727|imex:IM-27830-182 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_066563.2|refseq:NP_995580.1|ensembl:ENSG00000197696(gene)|ensembl:ENST00000360476(transcript)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0007165"(signal transduction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0031710"(neuromedin B receptor binding)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043005"(neuron projection)|go:"GO:0046887"(positive regulation of hormone secretion)|go:"GO:0046888"(negative regulation of hormone secretion)|go:"GO:0050482"(arachidonic acid secretion)|interpro:IPR000874(Bombesin-like peptide)|rcsb pdb:1C98|rcsb pdb:1C9A|reactome:R-HSA-375276|reactome:R-HSA-416476|go:"GO:0005184"(neuropeptide hormone activity) uniprotkb:P0C6X7(chain-parent)|intact:EBI-7843867(chain-parent) - comment:mint chain-seq-start:2741|chain-seq-end:3240 figure legend:ST1|comment:"Library for Y2H screening used: ORFeome"|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/19 2020/04/09 rogid:A5rA3w1WCotJZUAYPUi5ebRxe7Q9606 rogid:smPAOI1nAWgLZFomtwoLSa1N9vI694009 rigid:CYaq7TCuU08K8EGmQE94+qhUgyg false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P0C6X7-PRO_0000037311 uniprotkb:Q96GS6 intact:EBI-25474079 intact:EBI-2870273|uniprotkb:Q6PJU2|uniprotkb:A8K0G8|uniprotkb:Q9BWL0|uniprotkb:Q8WUH9|uniprotkb:Q9H7Q9|uniprotkb:D6W5Z9|ensembl:ENSP00000292577|ensembl:ENSP00000504042 psi-mi:p0c6x7-pro_0000037311(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:ab17a_human(display_long)|uniprotkb:ABHD17A(gene name)|psi-mi:ABHD17A(display_short)|uniprotkb:C19orf27(gene name synonym)|uniprotkb:FAM108A1(gene name synonym) psi-mi:"MI:0398"(two hybrid pooling approach) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25488714|imex:IM-27830-26 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7843867(chain-parent) refseq:XP_011526640.1|refseq:XP_016882830.1|refseq:NP_001123583.1|refseq:NP_112490.3|ensembl:ENSG00000129968(gene)|ensembl:ENST00000292577(transcript)|ensembl:ENST00000676686(transcript)|go:"GO:0002084"(protein depalmitoylation)|go:"GO:0005886"(plasma membrane)|go:"GO:0008474"("palmitoyl-(protein) hydrolase activity")|go:"GO:0010008"(endosome membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099033"(anchored component of postsynaptic recycling endosome membrane)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:1902817"(negative regulation of protein localization to microtubule)|go:"GO:1905668"(positive regulation of protein localization to endosome)|interpro:IPR022742|interpro:IPR029058|mint:Q96GS6|reactome:R-HSA-9648002|go:"GO:0016020"(membrane) - chain-seq-start:819|chain-seq-end:2740 - figure legend:ST1|comment:"Library for Y2H screening used: fetal brain"|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/19 2020/03/31 rogid:NKZ5d0D2HjefhmJQwgHz+M1lSt8694009 rogid:eZ6J8YENMgDhwA9IrEscvsGst+w9606 rigid:3AxVW8z0DEPOXhqHSJBB8fSSPAQ false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P0C6X7-PRO_0000037311 uniprotkb:Q86VK4 intact:EBI-25474079 intact:EBI-720304|uniprotkb:O00153|uniprotkb:Q9BQ19|ensembl:ENSP00000451763|uniprotkb:B4DR78|uniprotkb:B4DDV5 psi-mi:p0c6x7-pro_0000037311(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:zn410_human(display_long)|uniprotkb:Zinc finger protein APA-1(gene name synonym)|uniprotkb:Another partner for ARF 1(gene name synonym)|uniprotkb:ZNF410(gene name)|psi-mi:ZNF410(display_short)|uniprotkb:APA1(gene name synonym) psi-mi:"MI:0398"(two hybrid pooling approach) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25488707|imex:IM-27830-228 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7843867(chain-parent) refseq:NP_001229856.1|ensembl:ENSG00000119725(gene)|ensembl:ENST00000555044(transcript)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|rcsb pdb:6WMI|refseq:NP_001229855.1|refseq:NP_067011.1|refseq:NP_001229853.1 - chain-seq-start:819|chain-seq-end:2740 - figure legend:ST1|comment:"Library for Y2H screening used: fetal brain"|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/19 2020/03/31 rogid:NKZ5d0D2HjefhmJQwgHz+M1lSt8694009 rogid:oe1n/awl/uodcjNUOgHoix5bp9Y9606 rigid:98H6yzlmclGdNCR/ZaeWyD/CEUc false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q53GL0 uniprotkb:P0C6X7-PRO_0000037314 intact:EBI-949945|ensembl:ENSP00000358120|uniprotkb:Q336K5|uniprotkb:Q8IZ51|uniprotkb:Q9UL48|uniprotkb:Q9NRV3 intact:EBI-25487672 psi-mi:pkho1_human(display_long)|uniprotkb:HQ0024c(orf name)|uniprotkb:PLEKHO1(gene name)|psi-mi:PLEKHO1(display_short)|uniprotkb:CKIP1(gene name synonym)|uniprotkb:Casein kinase 2-interacting protein 1(gene name synonym)|uniprotkb:Osteoclast maturation-associated gene 120 protein(gene name synonym)|uniprotkb:C-Jun-binding protein(gene name synonym)|uniprotkb:OC120(gene name synonym) psi-mi:p0c6x7-pro_0000037314(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:"MI:0398"(two hybrid pooling approach) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25488844|imex:IM-27830-234 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057358.2|go:"GO:0008360"(regulation of cell shape)|go:"GO:0032587"(ruffle membrane)|go:"GO:0036195"(muscle cell projection membrane)|go:"GO:0051451"(myoblast migration)|go:"GO:0072673"(lamellipodium morphogenesis)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR028452|interpro:IPR043448|mint:Q53GL0|rcsb pdb:3AA1|ensembl:ENSG00000023902(gene)|ensembl:ENST00000369124(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007520"(myoblast fusion)|refseq:NP_001291651.1|refseq:NP_001291652.1|refseq:NP_001291653.1|ensembl:ENSP00000358120|refseq:XP_016856909.1|dip:DIP-46903N intact:EBI-7843867(chain-parent)|uniprotkb:P0C6X7(chain-parent) - - chain-seq-start:3837|chain-seq-end:3919 figure legend:ST1|comment:"Library for Y2H screening used: fetal brain"|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/19 2020/03/31 rogid:f+fuKzDy9VwrKcC9fJMo3JqRenM9606 rogid:95nEGuIgfxXAK4CVWXC+sH1eT+c694009 rigid:FvGlBK/9dwznx7bFg2S6akvS8NM false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P0C6X7-PRO_0000037314 uniprotkb:P13796 intact:EBI-25487672 intact:EBI-698036|uniprotkb:Q5TBN4|uniprotkb:B2R613|uniprotkb:B4DUA0|ensembl:ENSP00000315757|ensembl:ENSP00000381581 psi-mi:p0c6x7-pro_0000037314(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:plsl_human(display_long)|uniprotkb:L-plastin(gene name synonym)|uniprotkb:Lymphocyte cytosolic protein 1(gene name synonym)|uniprotkb:LC64P(gene name synonym)|uniprotkb:LCP1(gene name)|psi-mi:LCP1(display_short)|uniprotkb:PLS2(gene name synonym) psi-mi:"MI:0398"(two hybrid pooling approach) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25488851|imex:IM-27830-186 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7843867(chain-parent)|uniprotkb:P0C6X7(chain-parent) refseq:NP_002289.2|refseq:XP_005266431.1|dip:DIP-34767N|ensembl:ENSG00000136167(gene)|ensembl:ENST00000323076(transcript)|ensembl:ENST00000398576(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001891"(phagocytic cup)|go:"GO:0002102"(podosome)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0003779"(actin binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016477"(cell migration)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030054"(cell junction)|go:"GO:0030175"(filopodium)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0032432"(actin filament bundle)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033157"(regulation of intracellular protein transport)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051020"(GTPase binding)|go:"GO:0051639"(actin filament network formation)|go:"GO:0051764"(actin crosslink formation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071803"(positive regulation of podosome assembly)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR036872|interpro:IPR039956|interpro:IPR039959|rcsb pdb:2D85|rcsb pdb:5JOJ|rcsb pdb:5JOL|reactome:R-HSA-8950505 - chain-seq-start:3837|chain-seq-end:3919 - figure legend:ST1|comment:"Library for Y2H screening used: brain"|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/19 2020/03/31 rogid:95nEGuIgfxXAK4CVWXC+sH1eT+c694009 rogid:1uy1zhroB3GHUiAwLjEdP5Rz1xM9606 rigid:KWWSjyEbnYJ5JOdjSFeMb1LmoXQ false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P0C6X7-PRO_0000037316 uniprotkb:Q6P587 intact:EBI-25475825 intact:EBI-597013|uniprotkb:Q6FIC7|uniprotkb:Q96RY1|uniprotkb:Q9H0N6|uniprotkb:B1AK41|uniprotkb:B1AK40|ensembl:ENSP00000398053 psi-mi:p0c6x7-pro_0000037316(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:fahd1_human(display_long)|uniprotkb:FAHD1(gene name)|psi-mi:FAHD1(display_short)|uniprotkb:C16orf36(gene name synonym)|uniprotkb:Fumarylacetoacetate hydrolase domain-containing protein 1(gene name synonym)|uniprotkb:YISKL(gene name synonym)|uniprotkb:YisK-like protein(gene name synonym)|uniprotkb:Oxaloacetate decarboxylase(gene name synonym) psi-mi:"MI:0398"(two hybrid pooling approach) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25488921|imex:IM-27830-126 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7843867(chain-parent) refseq:NP_001018114.1|refseq:NP_001135870.1|refseq:NP_112485.1|ensembl:ENSG00000180185(gene)|ensembl:ENST00000427358(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0008948"(oxaloacetate decarboxylase activity)|go:"GO:0018773"(acetylpyruvate hydrolase activity)|go:"GO:0034545"(fumarylpyruvate hydrolase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0047621"(acylpyruvate hydrolase activity)|interpro:IPR011234(Fumarylacetoacetase, C-terminal-related)|interpro:IPR036663|rcsb pdb:1SAW|rcsb pdb:6FOG|rcsb pdb:6FOH|reactome:R-HSA-71403 - chain-seq-start:4118|chain-seq-end:4230 - figure legend:ST1|comment:"Library for Y2H screening used: brain, fetal brain"|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/19 2020/03/31 rogid:djbtL5LNKDagWRnaJOlJM8BS5lU694009 rogid:+TBWTaRxrIz2Y0dfwkSNf8VZEcw9606 rigid:RAhFpfIqIrvIG8TPMD59vmkbA0E false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P0C6X7-PRO_0000037316 uniprotkb:Q9UQN3 intact:EBI-25475825 intact:EBI-718324|uniprotkb:Q53HC7|uniprotkb:Q9Y4U6|intact:EBI-11161391|uniprotkb:B4DJG8|ensembl:ENSP00000263780 psi-mi:p0c6x7-pro_0000037316(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:chm2b_human(display_long)|uniprotkb:Chromatin-modifying protein 2b(gene name synonym)|uniprotkb:CHMP2.5(gene name synonym)|uniprotkb:Vacuolar protein sorting-associated protein 2-2(gene name synonym)|uniprotkb:CHMP2B(gene name)|psi-mi:CHMP2B(display_short)|uniprotkb:CGI-84(orf name) psi-mi:"MI:0398"(two hybrid pooling approach) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25488900|imex:IM-27830-172 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7843867(chain-parent) refseq:NP_054762.2|refseq:NP_001231573.1|ensembl:ENSG00000083937(gene)|ensembl:ENST00000263780(transcript)|go:"GO:0000815"(ESCRT III complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005771"(multivesicular body)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0006997"(nucleus organization)|go:"GO:0007032"(endosome organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016236"(macroautophagy)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032509"(endosome transport via multivesicular body sorting pathway)|go:"GO:0036258"(multivesicular body assembly)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0045296"(cadherin binding)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0050890"(cognition)|go:"GO:0061763"(multivesicular body-lysosome fusion)|go:"GO:0061952"(midbody abscission)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099159"(regulation of modification of postsynaptic structure)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:1901673"(regulation of mitotic spindle assembly)|go:"GO:1902188"(obsolete positive regulation of viral release from host cell)|go:"GO:1904903"(ESCRT III complex disassembly)|interpro:IPR005024(Snf7)|mint:Q9UQN3|rcsb pdb:2JQK|reactome:R-HSA-162588|reactome:R-HSA-1632852|reactome:R-HSA-5620971|reactome:R-HSA-917729|reactome:R-HSA-9610379|reactome:R-HSA-9615710|reactome:R-HSA-9668328|reactome:R-HSA-9679504|reactome:R-HSA-9694676|go:"GO:0010824"(regulation of centrosome duplication)|dip:DIP-50766N - chain-seq-start:4118|chain-seq-end:4230 - figure legend:ST1|comment:"Library for Y2H screening used: fetal brain"|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/19 2020/03/31 rogid:djbtL5LNKDagWRnaJOlJM8BS5lU694009 rogid:WmtZzxKkbkLsgFov/DJDKKGvIto9606 rigid:60pjZMccWoR9uPnbaHt6Vl7ufMo false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P0C6X7-PRO_0000037315 uniprotkb:P23588 intact:EBI-25487941 intact:EBI-970310|ensembl:ENSP00000262056|uniprotkb:Q4G0E3|uniprotkb:Q53HQ2|uniprotkb:Q6GPH5|uniprotkb:Q6IB46|uniprotkb:Q8WYK5|uniprotkb:B4DS13 psi-mi:p0c6x7-pro_0000037315(display_long)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)|uniprotkb:rep(gene name)|psi-mi:rep(display_short) psi-mi:if4b_human(display_long)|uniprotkb:EIF4B(gene name)|psi-mi:EIF4B(display_short) psi-mi:"MI:0398"(two hybrid pooling approach) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25488893|imex:IM-27830-124 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7843867(chain-parent)|uniprotkb:P0C6X7(chain-parent) ensembl:ENSG00000063046(gene)|ensembl:ENST00000262056(transcript)|go:"GO:0001731"(formation of translation preinitiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0016281"(eukaryotic translation initiation factor 4F complex)|go:"GO:0030425"(dendrite)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034057"(RNA strand-exchange activity)|go:"GO:0043024"(ribosomal small subunit binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0097010"(eukaryotic translation initiation factor 4F complex assembly)|go:"GO:0098794"(postsynapse)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033107|interpro:IPR035979|mint:P23588|rcsb pdb:1WI8|rcsb pdb:2J76|rcsb pdb:6FEC|reactome:R-HSA-156827|reactome:R-HSA-166208|reactome:R-HSA-429947|reactome:R-HSA-72649|reactome:R-HSA-72662|reactome:R-HSA-72702|reactome:R-HSA-72706|refseq:NP_001408.2|refseq:NP_001317583.1 - chain-seq-start:3920|chain-seq-end:4117 - figure legend:ST1|comment:"Library for Y2H screening used: fetal brain"|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/19 2020/03/31 rogid:3oIsD98B0aiO0Sqlv5jCglM4pgE694009 rogid:6QlRkSj6suC5apkUxdZhOq+OMBc9606 rigid:DVMeBZhIQ/I1sK+umrw56bNVih0 false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P0C6X7-PRO_0000037315 uniprotkb:P54274 intact:EBI-25487941 intact:EBI-710997|uniprotkb:A7XP29|uniprotkb:Q15553|uniprotkb:Q93029|ensembl:ENSP00000276603|uniprotkb:Q8NHT6 psi-mi:p0c6x7-pro_0000037315(display_long)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)|uniprotkb:rep(gene name)|psi-mi:rep(display_short) psi-mi:terf1_human(display_long)|uniprotkb:TTAGGG repeat-binding factor 1(gene name synonym)|uniprotkb:NIMA-interacting protein 2(gene name synonym)|uniprotkb:Telomeric protein Pin2/TRF1(gene name synonym)|uniprotkb:TERF1(gene name)|psi-mi:TERF1(display_short)|uniprotkb:PIN2(gene name synonym)|uniprotkb:TRF(gene name synonym)|uniprotkb:TRF1(gene name synonym)|uniprotkb:TRBF1(gene name synonym) psi-mi:"MI:0398"(two hybrid pooling approach) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25488879|imex:IM-27830-30 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7843867(chain-parent)|uniprotkb:P0C6X7(chain-parent) refseq:NP_003209.2|refseq:NP_059523.2|ensembl:ENSG00000147601(gene)|go:"GO:0051301"(cell division)|go:"GO:0051974"(negative regulation of telomerase activity)|ensembl:ENST00000276603(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0001650"(fibrillar center)|go:"GO:0003677"(DNA binding)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0008017"(microtubule binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0008301"(DNA binding, bending)|go:"GO:0016604"(nuclear body)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032214"(negative regulation of telomere maintenance via semi-conservative replication)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045141"(meiotic telomere clustering)|interpro:IPR013867(Telomere repeat binding factor, dimerisation)|interpro:IPR017357(Telomeric repeat-binding factor 1, Pin2)|interpro:IPR017930|interpro:IPR036507|mint:P54274|rcsb pdb:1BA5|rcsb pdb:1H6O|rcsb pdb:1ITY|rcsb pdb:1IV6|rcsb pdb:1W0T|rcsb pdb:3BQO|rcsb pdb:3L82|rcsb pdb:5HKP|rcsb pdb:5WIR|rcsb pdb:5XUP|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-171319|reactome:R-HSA-174411|reactome:R-HSA-174414|reactome:R-HSA-174417|reactome:R-HSA-174430|reactome:R-HSA-174437|reactome:R-HSA-2559586|reactome:R-HSA-9670095|go:"GO:0061820"(telomeric D-loop disassembly)|go:"GO:0070187"(shelterin complex)|go:"GO:0071532"(ankyrin repeat binding)|go:"GO:0090656"(t-circle formation)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1904792"(positive regulation of shelterin complex assembly)|go:"GO:1904850"(negative regulation of establishment of protein localization to telomere)|go:"GO:1904911"(negative regulation of establishment of RNA localization to telomere)|go:"GO:1904914"(negative regulation of establishment of protein-containing complex localization to telomere)|go:"GO:1905778"(negative regulation of exonuclease activity)|go:"GO:1905839"(negative regulation of telomeric D-loop disassembly)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR009057(Homeodomain-like)|dip:DIP-29412N - chain-seq-start:3920|chain-seq-end:4117 - figure legend:ST1|comment:"Library for Y2H screening used: fetal brain"|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/19 2020/03/31 rogid:3oIsD98B0aiO0Sqlv5jCglM4pgE694009 rogid:3Tjmp8hqEhLBIQqxxWHntpL4hz49606 rigid:mumPt5Wr4ANc1EmtK6oeQIpuzvM false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P0C6X7-PRO_0000037315 uniprotkb:Q9P0M6 intact:EBI-25487941 intact:EBI-3922608|uniprotkb:Q5SQT2|ensembl:ENSP00000503835|ensembl:ENSP00000362352 psi-mi:p0c6x7-pro_0000037315(display_long)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)|uniprotkb:rep(gene name)|psi-mi:rep(display_short) psi-mi:h2aw_human(display_long)|uniprotkb:MACROH2A2(gene name)|psi-mi:MACROH2A2(display_short)|uniprotkb:H2AFY2(gene name synonym) psi-mi:"MI:0398"(two hybrid pooling approach) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25488872|imex:IM-27830-110 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7843867(chain-parent)|uniprotkb:P0C6X7(chain-parent) dip:DIP-48563N|refseq:NP_061119.1|ensembl:ENSG00000099284(gene)|ensembl:ENST00000373255(transcript)|ensembl:ENST00000679349(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000786"(nucleosome)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001740"(Barr body)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006342"|go:"GO:0007420"(brain development)|go:"GO:0007549"(dosage compensation)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0045618"(positive regulation of keratinocyte differentiation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071169"(establishment of protein localization to chromatin)|go:"GO:1901837"(negative regulation of transcription of nucleolar large rRNA by RNA polymerase I)|interpro:IPR002119(Histone H2A)|interpro:IPR002589(Appr-1-p processing)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR021171|interpro:IPR032454|interpro:IPR035796|interpro:IPR043472|rcsb pdb:2XD7|rcsb pdb:6FY5 - chain-seq-start:3920|chain-seq-end:4117 - figure legend:ST1|comment:"Library for Y2H screening used: brain"|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/19 2020/03/31 rogid:3oIsD98B0aiO0Sqlv5jCglM4pgE694009 rogid:xOLJc5I2oZLPBDLrA5IT2lYBQFM9606 rigid:DmM9WfrTwkp6tKFEFb8RCpbWu5E false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P0C6X7-PRO_0000037315 uniprotkb:Q9Y6E2 intact:EBI-25487941 intact:EBI-1051021|uniprotkb:Q3B779|uniprotkb:Q9H3F7|uniprotkb:A4D123|uniprotkb:Q96JW5|ensembl:ENSP00000258761|ensembl:ENSP00000397249 psi-mi:p0c6x7-pro_0000037315(display_long)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)|uniprotkb:rep(gene name)|psi-mi:rep(display_short) psi-mi:bzw2_human(display_long)|uniprotkb:BZW2(gene name)|psi-mi:BZW2(display_short)|uniprotkb:HSPC028(orf name)|uniprotkb:MSTP017(orf name) psi-mi:"MI:0398"(two hybrid pooling approach) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25488865|imex:IM-27830-58 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7843867(chain-parent)|uniprotkb:P0C6X7(chain-parent) refseq:NP_001153239.1|refseq:NP_054757.1|ensembl:ENSG00000136261(gene)|ensembl:ENST00000258761(transcript)|ensembl:ENST00000433922(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0007399"(nervous system development)|go:"GO:0016020"(membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0045296"(cadherin binding)|interpro:IPR003307(eIF4-gamma/eIF5/eIF2-epsilon)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR043510|refseq:XP_006715769.1|refseq:XP_006715770.1|refseq:XP_006715771.1 - chain-seq-start:3920|chain-seq-end:4117 - figure legend:ST1|comment:"Library for Y2H screening used: brain"|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/19 2020/03/31 rogid:3oIsD98B0aiO0Sqlv5jCglM4pgE694009 rogid:+z22Ykb6e3IM9zk51m6tjuhiEcU9606 rigid:bhXDonRj3V+b/MGOgGyYFADU/yM false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P0C6X7-PRO_0000037315 uniprotkb:P69849 intact:EBI-25487941 intact:EBI-947048|ensembl:ENSP00000382274|ensembl:ENSP00000483234|ensembl:ENSP00000504325|ensembl:ENSP00000504575 psi-mi:p0c6x7-pro_0000037315(display_long)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)|uniprotkb:rep(gene name)|psi-mi:rep(display_short) psi-mi:nomo3_human(display_long)|uniprotkb:NOMO3(gene name)|psi-mi:NOMO3(display_short)|uniprotkb:pM5 protein 3(gene name synonym) psi-mi:"MI:0398"(two hybrid pooling approach) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25488858|imex:IM-27830-170 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7843867(chain-parent)|uniprotkb:P0C6X7(chain-parent) refseq:NP_001004067.1|ensembl:ENSG00000103226(gene)|ensembl:ENSG00000278087(gene)|ensembl:ENST00000399336(transcript)|ensembl:ENST00000611106(transcript)|ensembl:ENST00000676846(transcript)|ensembl:ENST00000677777(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0043022"(ribosome binding)|go:"GO:1900108"(negative regulation of nodal signaling pathway)|interpro:IPR008969(Carboxypeptidase-like, regulatory region)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013784(Carbohydrate-binding-like fold)|interpro:IPR041033 - chain-seq-start:3920|chain-seq-end:4117 - figure legend:ST1|comment:"Library for Y2H screening used: brain"|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/19 2020/03/31 rogid:3oIsD98B0aiO0Sqlv5jCglM4pgE694009 rogid:niOgaMEyjLXQF9fJDpnCnVgDdic9606 rigid:HLSkBgXNAtHNYGHVcJe22QSyQlA false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P0C6X7-PRO_0000037316 uniprotkb:Q7Z494 intact:EBI-25475825 intact:EBI-2804263|uniprotkb:Q68D99|uniprotkb:Q8NCM5|uniprotkb:Q7Z493|uniprotkb:Q5JPE3|uniprotkb:Q96NK2|uniprotkb:Q5JPE6|uniprotkb:Q6NVH3|uniprotkb:Q96N70|uniprotkb:Q7Z492|uniprotkb:Q8N9R2|ensembl:ENSP00000338766 psi-mi:p0c6x7-pro_0000037316(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:nphp3_human(display_long)|uniprotkb:KIAA2000(gene name synonym)|uniprotkb:NPHP3(gene name)|psi-mi:NPHP3(display_short) psi-mi:"MI:0398"(two hybrid pooling approach) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25488914|imex:IM-27830-60 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7843867(chain-parent) refseq:NP_694972.3|ensembl:ENSG00000113971(gene)|ensembl:ENST00000337331(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001947"(heart looping)|go:"GO:0003283"(atrial septum development)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030324"(lung development)|go:"GO:0035469"(determination of pancreatic left/right asymmetry)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048496"(maintenance of animal organ identity)|go:"GO:0060027"(convergent extension involved in gastrulation)|go:"GO:0060271"(cilium assembly)|go:"GO:0060287"(epithelial cilium movement involved in determination of left/right asymmetry)|go:"GO:0060993"(kidney morphogenesis)|go:"GO:0071908"(determination of intestine left/right asymmetry)|go:"GO:0071909"(determination of stomach left/right asymmetry)|go:"GO:0071910"(determination of liver left/right asymmetry)|go:"GO:0072189"(ureter development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:2000095"(regulation of Wnt signaling pathway, planar cell polarity pathway)|go:"GO:2000167"(regulation of planar cell polarity pathway involved in neural tube closure)|rcsb pdb:5L7K|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR027417|reactome:R-HSA-5624138 - chain-seq-start:4118|chain-seq-end:4230 - figure legend:ST1|comment:"Library for Y2H screening used: fetal brain"|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/19 2020/03/31 rogid:djbtL5LNKDagWRnaJOlJM8BS5lU694009 rogid:7SitCJ9bwhu4VXh9FjX/wWCq0UQ9606 rigid:sBCHABW/jic3zeI/nbAZKqgXrSg false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P0C6X7-PRO_0000037316 uniprotkb:Q9BUV0 intact:EBI-25475825 intact:EBI-745604|uniprotkb:Q49AA4|uniprotkb:Q5TH71|uniprotkb:Q9GZP6|uniprotkb:A8K917|ensembl:ENSP00000243189 psi-mi:p0c6x7-pro_0000037316(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:rsrp1_human(display_long)|uniprotkb:RSRP1(gene name)|psi-mi:RSRP1(display_short)|uniprotkb:C1orf63(gene name synonym)|uniprotkb:HT033(orf name)|uniprotkb:NPD014(orf name) psi-mi:"MI:0398"(two hybrid pooling approach) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25488907|imex:IM-27830-238 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7843867(chain-parent) refseq:NP_064713.3|refseq:XP_011540099.1|ensembl:ENSG00000117616(gene)|ensembl:ENST00000243189(transcript)|interpro:IPR029656|mint:Q9BUV0|refseq:NP_001308701.1 - chain-seq-start:4118|chain-seq-end:4230 - figure legend:ST1|comment:"Library for Y2H screening used: brain, fetal brain"|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/19 2020/03/31 rogid:djbtL5LNKDagWRnaJOlJM8BS5lU694009 rogid:IugruP8t4mowi3v7H1DCMkmPBhI9606 rigid:663gjq4bEX1ueIH0HmndNq8Urwk false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P0C6X7-PRO_0000037315 uniprotkb:P05155 intact:EBI-25487941 intact:EBI-1223454|uniprotkb:Q547W3|uniprotkb:Q59EI5|uniprotkb:Q96FE0|uniprotkb:A6NMU0|uniprotkb:A8KAI9|uniprotkb:B2R6L5|uniprotkb:Q16304|uniprotkb:Q7Z455|uniprotkb:Q9UC49|uniprotkb:Q9UCF9|uniprotkb:B4E1F0|uniprotkb:B4E1H2|ensembl:ENSP00000278407|ensembl:ENSP00000504807 psi-mi:p0c6x7-pro_0000037315(display_long)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)|uniprotkb:rep(gene name)|psi-mi:rep(display_short) psi-mi:ic1_human(display_long)|uniprotkb:SERPING1(gene name)|psi-mi:SERPING1(display_short)|uniprotkb:C1IN(gene name synonym)|uniprotkb:C1NH(gene name synonym)|uniprotkb:C1 esterase inhibitor(gene name synonym)|uniprotkb:C1-inhibiting factor(gene name synonym)|uniprotkb:Serpin G1(gene name synonym) psi-mi:"MI:0398"(two hybrid pooling approach) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25488886|imex:IM-27830-236 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7843867(chain-parent)|uniprotkb:P0C6X7(chain-parent) refseq:NP_000053.2|refseq:NP_001027466.1|dip:DIP-45635N|ensembl:ENSG00000149131(gene)|ensembl:ENST00000278407(transcript)|ensembl:ENST00000676670(transcript)|go:"GO:0001869"(negative regulation of complement activation, lectin pathway)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0007568"(aging)|go:"GO:0007596"(blood coagulation)|go:"GO:0008015"(blood circulation)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0042730"(fibrinolysis)|go:"GO:0045087"(innate immune response)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR015553(Protease inhibitor I4, serpin C1)|interpro:IPR023795|interpro:IPR023796|interpro:IPR036186|interpro:IPR042178|interpro:IPR042185|mint:P05155|rcsb pdb:1M6Q|rcsb pdb:2OAY|rcsb pdb:5DU3|rcsb pdb:5DUQ|rcsb pdb:7AKV|reactome:R-HSA-114608|reactome:R-HSA-140837|reactome:R-HSA-9657689|reactome:R-HSA-977606 - chain-seq-start:3920|chain-seq-end:4117 - figure legend:ST1|comment:"Library for Y2H screening used: fetal brain"|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/19 2020/03/31 rogid:3oIsD98B0aiO0Sqlv5jCglM4pgE694009 rogid:Y7cqCZ6Ryz51dsi6jM86EXdfeWc9606 rigid:PY76OKDC7uOPuByv1i3O72qQwbU false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P0C6X7-PRO_0000037316 uniprotkb:P06733 intact:EBI-25475825 intact:EBI-353877|uniprotkb:P22712|uniprotkb:Q16704|uniprotkb:Q4TUS4|uniprotkb:Q658M5|uniprotkb:Q6GMP2|uniprotkb:Q71V37|uniprotkb:Q7Z3V6|uniprotkb:Q8WU71|uniprotkb:Q96GV1|uniprotkb:Q9BT62|uniprotkb:Q9UM55|ensembl:ENSP00000234590|uniprotkb:B2RD59|uniprotkb:Q53FT9|uniprotkb:Q53HR3|uniprotkb:Q9UCH6 psi-mi:p0c6x7-pro_0000037316(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:enoa_human(display_long)|uniprotkb:ENO1(gene name)|psi-mi:ENO1(display_short)|uniprotkb:ENO1L1(gene name synonym)|uniprotkb:MBPB1(gene name synonym)|uniprotkb:MPB1(gene name synonym)|uniprotkb:2-phospho-D-glycerate hydro-lyase(gene name synonym)|uniprotkb:Non-neural enolase(gene name synonym)|uniprotkb:Enolase 1(gene name synonym)|uniprotkb:Phosphopyruvate hydratase(gene name synonym)|uniprotkb:C-myc promoter-binding protein(gene name synonym)|uniprotkb:MBP-1(gene name synonym)|uniprotkb:MPB-1(gene name synonym)|uniprotkb:Plasminogen-binding protein(gene name synonym) psi-mi:"MI:0398"(two hybrid pooling approach) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25488928|imex:IM-27830-62 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7843867(chain-parent) refseq:NP_001188412.1|refseq:NP_001419.1|ensembl:ENSG00000074800(gene)|ensembl:ENST00000234590(transcript)|go:"GO:0000015"(phosphopyruvate hydratase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003723"(RNA binding)|go:"GO:0004634"(phosphopyruvate hydratase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006096"(glycolytic process)|go:"GO:0009615"(response to virus)|go:"GO:0009986"(cell surface)|go:"GO:0010756"(positive regulation of plasminogen activation)|go:"GO:0016020"(membrane)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031430"(M band)|go:"GO:0032889"(regulation of vacuole fusion, non-autophagic)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045933"(positive regulation of muscle contraction)|go:"GO:0051020"(GTPase binding)|go:"GO:0061621"(canonical glycolysis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0099738"(cell cortex region)|go:"GO:1903298"(negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR000941(Enolase)|interpro:IPR020809|interpro:IPR020810|interpro:IPR020811|interpro:IPR029017|interpro:IPR036849|mint:P06733|rcsb pdb:2PSN|rcsb pdb:3B97|rcsb pdb:5JLZ|rcsb pdb:5LAX|rcsb pdb:5NI9|rcsb pdb:5NIG|rcsb pdb:5OCK|reactome:R-HSA-70171|reactome:R-HSA-70263|reactome:R-HSA-9636667 - chain-seq-start:4118|chain-seq-end:4230 - figure legend:ST1|comment:"Library for Y2H screening used: brain, fetal brain"|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/19 2020/03/31 rogid:djbtL5LNKDagWRnaJOlJM8BS5lU694009 rogid:RmP7cr55H8ylcgBOEyivwljIE+09606 rigid:vWU1rHyIfnzmwuDpaT5emvS58tc false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P0C6X7-PRO_0000037316 uniprotkb:Q5SQN1 intact:EBI-25475825 intact:EBI-10244848|uniprotkb:Q8TB31|uniprotkb:Q9BT10|uniprotkb:Q5TBZ3|uniprotkb:Q96FE1|uniprotkb:Q8N558|uniprotkb:Q8WV46|uniprotkb:Q96CQ3|uniprotkb:Q8TCW8|uniprotkb:Q96NU3|uniprotkb:Q5HYB5|uniprotkb:Q96I66|uniprotkb:Q9BVB2|uniprotkb:B6EDE0 psi-mi:p0c6x7-pro_0000037316(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:snp47_human(display_long)|uniprotkb:SNAP47(gene name)|psi-mi:SNAP47(display_short)|uniprotkb:C1orf142(gene name synonym)|uniprotkb:Epididymis luminal protein 170(gene name synonym)|uniprotkb:HEL170(gene name synonym)|uniprotkb:SVAP1(gene name synonym)|uniprotkb:Synaptosomal-associated 47 kDa protein(gene name synonym) psi-mi:"MI:0398"(two hybrid pooling approach) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25488935|imex:IM-27830-86 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7843867(chain-parent) interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR000727(Target SNARE coiled-coil region)|refseq:NP_444280.2|refseq:NP_001310864.1|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0012505"(endomembrane system)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0019905"(syntaxin binding)|go:"GO:0031201"(SNARE complex)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0098793"(presynapse)|refseq:XP_016855720.1|refseq:XP_016855721.1 - chain-seq-start:4118|chain-seq-end:4230 - figure legend:ST1|comment:"Library for Y2H screening used: fetal brain"|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/19 2020/03/31 rogid:djbtL5LNKDagWRnaJOlJM8BS5lU694009 rogid:hKGKMfU5GPf/qU+vuwByphqX3NA9606 rigid:8lZV1Q3qYOMqxs+K7hQmbixuD7I false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q7TLC7 uniprotkb:O14964 intact:EBI-25488942 intact:EBI-740220|uniprotkb:Q9NR36|ensembl:ENSP00000331201|ensembl:ENSP00000504106 psi-mi:y14_sars(display_long)|uniprotkb:ORF14(orf name) psi-mi:hgs_human(display_long)|uniprotkb:Protein pp110(gene name synonym)|uniprotkb:Hrs(gene name synonym)|uniprotkb:HGS(gene name)|psi-mi:HGS(display_short)|uniprotkb:HRS(gene name synonym) psi-mi:"MI:0398"(two hybrid pooling approach) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25488947|imex:IM-27830-240 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0042802"(identical protein binding)|interpro:IPR035113 refseq:NP_004703.1|dip:DIP-29050N|ensembl:ENSG00000185359(gene)|ensembl:ENST00000329138(transcript)|ensembl:ENST00000676546(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0007165"(signal transduction)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010324"(membrane invagination)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0016197"(endosomal transport)|go:"GO:0016236"(macroautophagy)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0033565"(ESCRT-0 complex)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0036258"(multivesicular body assembly)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043405"(regulation of MAP kinase activity)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0097013"(phagocytic vesicle lumen)|go:"GO:1903543"(positive regulation of exosomal secretion)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR002014(VHS)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR008942(ENTH/VHS)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017073(Ubiquitin binding protein, Hrs/VPS27)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR024641|mint:O14964|rcsb pdb:2D3G|rcsb pdb:3F1I|rcsb pdb:3OBQ|rcsb pdb:3ZYQ|rcsb pdb:4AVX|reactome:R-HSA-182971|reactome:R-HSA-432720|reactome:R-HSA-5689880|reactome:R-HSA-6807004|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-9013420|reactome:R-HSA-917729|reactome:R-HSA-9635644|reactome:R-HSA-9636383|reactome:R-HSA-9706019 - - - figure legend:ST1|comment:"Library for Y2H screening used: ORFeome"|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/19 2020/03/31 rogid:neeKhbgFBkd1lYQvsZHB0OOs+lk694009 rogid:z/AnREuqEpyJ9/Zj6JFCJCJem1I9606 rigid:PyUtrebDAsTO5Xsa9OfGoyjIuiw false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q7TLC7 uniprotkb:P05155 intact:EBI-25488942 intact:EBI-1223454|uniprotkb:Q547W3|uniprotkb:Q59EI5|uniprotkb:Q96FE0|uniprotkb:A6NMU0|uniprotkb:A8KAI9|uniprotkb:B2R6L5|uniprotkb:Q16304|uniprotkb:Q7Z455|uniprotkb:Q9UC49|uniprotkb:Q9UCF9|uniprotkb:B4E1F0|uniprotkb:B4E1H2|ensembl:ENSP00000278407|ensembl:ENSP00000504807 psi-mi:y14_sars(display_long)|uniprotkb:ORF14(orf name) psi-mi:ic1_human(display_long)|uniprotkb:SERPING1(gene name)|psi-mi:SERPING1(display_short)|uniprotkb:C1IN(gene name synonym)|uniprotkb:C1NH(gene name synonym)|uniprotkb:C1 esterase inhibitor(gene name synonym)|uniprotkb:C1-inhibiting factor(gene name synonym)|uniprotkb:Serpin G1(gene name synonym) psi-mi:"MI:0398"(two hybrid pooling approach) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25488954|imex:IM-27830-112 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0042802"(identical protein binding)|interpro:IPR035113 refseq:NP_000053.2|refseq:NP_001027466.1|dip:DIP-45635N|ensembl:ENSG00000149131(gene)|ensembl:ENST00000278407(transcript)|ensembl:ENST00000676670(transcript)|go:"GO:0001869"(negative regulation of complement activation, lectin pathway)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0007568"(aging)|go:"GO:0007596"(blood coagulation)|go:"GO:0008015"(blood circulation)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0042730"(fibrinolysis)|go:"GO:0045087"(innate immune response)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR015553(Protease inhibitor I4, serpin C1)|interpro:IPR023795|interpro:IPR023796|interpro:IPR036186|interpro:IPR042178|interpro:IPR042185|mint:P05155|rcsb pdb:1M6Q|rcsb pdb:2OAY|rcsb pdb:5DU3|rcsb pdb:5DUQ|rcsb pdb:7AKV|reactome:R-HSA-114608|reactome:R-HSA-140837|reactome:R-HSA-9657689|reactome:R-HSA-977606 - - - figure legend:ST1|comment:"Library for Y2H screening used: fetal brain"|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/19 2020/03/31 rogid:neeKhbgFBkd1lYQvsZHB0OOs+lk694009 rogid:Y7cqCZ6Ryz51dsi6jM86EXdfeWc9606 rigid:nfXLCuzYxta/hZ8eKXOwJsTI4bQ false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q7TLC7 uniprotkb:Q13561 intact:EBI-25488942 intact:EBI-715074|uniprotkb:Q86YN2|uniprotkb:Q9BW17|uniprotkb:B2RBK5|ensembl:ENSP00000447824 psi-mi:y14_sars(display_long)|uniprotkb:ORF14(orf name) psi-mi:dctn2_human(display_long)|uniprotkb:Dynactin complex 50 kDa subunit(gene name synonym)|uniprotkb:50 kDa dynein-associated polypeptide(gene name synonym)|uniprotkb:p50 dynamitin(gene name synonym)|uniprotkb:DCTN2(gene name)|psi-mi:DCTN2(display_short)|uniprotkb:DCTN50(gene name synonym) psi-mi:"MI:0398"(two hybrid pooling approach) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25488961|imex:IM-27830-64 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0042802"(identical protein binding)|interpro:IPR035113 refseq:NP_006391.1|refseq:NP_001248341.1|refseq:NP_001248342.1|dip:DIP-37545N|reactome:R-HSA-2565942|reactome:R-HSA-3371497|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-6807878|reactome:R-HSA-6811436|reactome:R-HSA-8854518|ensembl:ENSG00000175203(gene)|ensembl:ENST00000548249(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005869"(dynactin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030286"(dynein complex)|go:"GO:0030426"(growth cone)|go:"GO:0030507"(spectrin binding)|go:"GO:0031982"(vesicle)|go:"GO:0032402"(melanosome transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071539"(protein localization to centrosome)|interpro:IPR028133|mint:Q13561|reactome:R-HSA-2132295 - - - figure legend:ST1|comment:"Library for Y2H screening used: brain"|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/19 2020/03/31 rogid:neeKhbgFBkd1lYQvsZHB0OOs+lk694009 rogid:JrL5jUtArek+zqmCkPKomnjuSf09606 rigid:kxbVv05TvGHFzJTpFKpnbbPBhjU false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q7TLC7 uniprotkb:Q9NRH1 intact:EBI-25488942 intact:EBI-712905|ensembl:ENSP00000223273|uniprotkb:B4DE83|uniprotkb:Q6IAF7|uniprotkb:Q8WVZ5|uniprotkb:A4D1W4 psi-mi:y14_sars(display_long)|uniprotkb:ORF14(orf name) psi-mi:yae1_human(display_long)|uniprotkb:YAE1(gene name)|psi-mi:YAE1(display_short)|uniprotkb:C7orf36(gene name synonym)|uniprotkb:YAE1D1(gene name synonym)|uniprotkb:Yae1 domain-containing protein 1(gene name synonym)|uniprotkb:GK003(orf name) psi-mi:"MI:0398"(two hybrid pooling approach) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25488968|imex:IM-27830-32 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0042802"(identical protein binding)|interpro:IPR035113 ensembl:ENSG00000241127(gene)|ensembl:ENST00000223273(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0106035"(protein maturation by [4Fe-4S] cluster transfer)|interpro:IPR019191|interpro:IPR038881|refseq:NP_064577.1|refseq:NP_001269375.1 - - - figure legend:ST1|comment:"Library for Y2H screening used: fetal brain"|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/19 2020/03/31 rogid:neeKhbgFBkd1lYQvsZHB0OOs+lk694009 rogid:SacccNxgOBtwPZGO+BOYtapKBUI9606 rigid:qV1L9GfrxBg39WZwHf2bSqMeJq0 false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:J9TC74 uniprotkb:Q13561 intact:EBI-25488975|uniprotkb:Q19QW9 intact:EBI-715074|uniprotkb:Q86YN2|uniprotkb:Q9BW17|uniprotkb:B2RBK5|ensembl:ENSP00000447824 psi-mi:j9tc74_sars(display_long)|uniprotkb:sars3a(gene name)|psi-mi:sars3a(display_short)|uniprotkb:ORF3a(gene name synonym) psi-mi:dctn2_human(display_long)|uniprotkb:Dynactin complex 50 kDa subunit(gene name synonym)|uniprotkb:50 kDa dynein-associated polypeptide(gene name synonym)|uniprotkb:p50 dynamitin(gene name synonym)|uniprotkb:DCTN2(gene name)|psi-mi:DCTN2(display_short)|uniprotkb:DCTN50(gene name synonym) psi-mi:"MI:0398"(two hybrid pooling approach) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25488983|imex:IM-27830-66 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005216"(ion channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|interpro:IPR024407 refseq:NP_006391.1|refseq:NP_001248341.1|refseq:NP_001248342.1|dip:DIP-37545N|reactome:R-HSA-2565942|reactome:R-HSA-3371497|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-6807878|reactome:R-HSA-6811436|reactome:R-HSA-8854518|ensembl:ENSG00000175203(gene)|ensembl:ENST00000548249(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005869"(dynactin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030286"(dynein complex)|go:"GO:0030426"(growth cone)|go:"GO:0030507"(spectrin binding)|go:"GO:0031982"(vesicle)|go:"GO:0032402"(melanosome transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071539"(protein localization to centrosome)|interpro:IPR028133|mint:Q13561|reactome:R-HSA-2132295 - - - figure legend:ST1|comment:"Library for Y2H screening used: ORFeome"|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/19 2020/03/31 rogid:G9PUTEgPb/GsDIis5WEafJ/h90c694009 rogid:JrL5jUtArek+zqmCkPKomnjuSf09606 rigid:rWl0PREzxuBN/maliHnviRzNs2o false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:J9TC74 uniprotkb:P62258 intact:EBI-25488975|uniprotkb:Q19QW9 intact:EBI-356498|uniprotkb:P29360|uniprotkb:P42655|uniprotkb:Q53XZ5|uniprotkb:Q63631|uniprotkb:Q7M4R4|uniprotkb:B3KY71|uniprotkb:D3DTH5|uniprotkb:Q4VJB6|ensembl:ENSP00000264335|ensembl:ENSP00000487356 psi-mi:j9tc74_sars(display_long)|uniprotkb:sars3a(gene name)|psi-mi:sars3a(display_short)|uniprotkb:ORF3a(gene name synonym) psi-mi:1433e_human(display_long)|uniprotkb:YWHAE(gene name)|psi-mi:YWHAE(display_short) psi-mi:"MI:0398"(two hybrid pooling approach) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25488990|imex:IM-27830-34 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005216"(ion channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|interpro:IPR024407 refseq:NP_006752.1|dip:DIP-36676N|reactome:R-HSA-1445148|reactome:R-HSA-2028269|reactome:R-HSA-205025|reactome:R-HSA-2565942|reactome:R-HSA-3371453|reactome:R-HSA-3371511|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-5625740|reactome:R-HSA-5628897|reactome:R-HSA-75035|reactome:R-HSA-8854518|reactome:R-HSA-8862803|reactome:R-HSA-8876198|ensembl:ENSG00000108953(gene)|ensembl:ENSG00000274474(gene)|ensembl:ENST00000264335(transcript)|ensembl:ENST00000627231(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0003064"(regulation of heart rate by hormone)|go:"GO:0003723"(RNA binding)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005925"(focal adhesion)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0060306"(regulation of membrane repolarization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0086013"(membrane repolarization during cardiac muscle cell action potential)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0090724"(central region of growth cone)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|go:"GO:1901020"(negative regulation of calcium ion transmembrane transporter activity)|go:"GO:1902309"(negative regulation of peptidyl-serine dephosphorylation)|go:"GO:1905913"(negative regulation of calcium ion export across plasma membrane)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P62258|rcsb pdb:2BR9|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6EIH|rcsb pdb:7C8E|reactome:R-HSA-111447 - - - figure legend:ST1|comment:"Library for Y2H screening used: fetal brain"|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/19 2020/03/31 rogid:G9PUTEgPb/GsDIis5WEafJ/h90c694009 rogid:mnuAjdnQZbMFojll2PnV3xFklXQ9606 rigid:8Ryx9Jx7t/QZ2rcSh3T8ZKdB8x8 false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:J9TC74 uniprotkb:Q99471 intact:EBI-25488975|uniprotkb:Q19QW9 intact:EBI-357275|ensembl:ENSP00000334188|ensembl:ENSP00000447942|intact:EBI-1047551|uniprotkb:A8K9A8|uniprotkb:Q54AA8|uniprotkb:Q9C083|uniprotkb:Q9C084 psi-mi:j9tc74_sars(display_long)|uniprotkb:sars3a(gene name)|psi-mi:sars3a(display_short)|uniprotkb:ORF3a(gene name synonym) psi-mi:pfd5_human(display_long)|uniprotkb:c-Myc-binding protein Mm-1(gene name synonym)|uniprotkb:PFDN5(gene name)|psi-mi:PFDN5(display_short)|uniprotkb:MM1(gene name synonym)|uniprotkb:Myc modulator 1(gene name synonym)|uniprotkb:PFD5(gene name synonym) psi-mi:"MI:0398"(two hybrid pooling approach) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25488997|imex:IM-27830-88 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005216"(ion channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|interpro:IPR024407 ensembl:ENSG00000123349(gene)|ensembl:ENST00000334478(transcript)|ensembl:ENST00000551018(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006457"(protein folding)|go:"GO:0016272"(prefoldin complex)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|interpro:IPR004127(Prefoldin alpha-like)|interpro:IPR009053(Prefoldin)|interpro:IPR011599(Prefoldin alpha subunit)|mint:Q99471|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|reactome:R-HSA-389957|refseq:NP_002615.2|refseq:NP_665904.1|dip:DIP-28155N - - - figure legend:ST1|comment:"Library for Y2H screening used: brain"|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/19 2020/03/31 rogid:G9PUTEgPb/GsDIis5WEafJ/h90c694009 rogid:Cm4km207qcfDJYRUCIwUxMBT4tE9606 rigid:mwAUvG0GDQ9gMr1sWL/g804nmMU false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P59633 uniprotkb:Q13561 intact:EBI-25489004|uniprotkb:Q7TFA9|uniprotkb:Q80BV4 intact:EBI-715074|uniprotkb:Q86YN2|uniprotkb:Q9BW17|uniprotkb:B2RBK5|ensembl:ENSP00000447824 psi-mi:ns3b_sars(display_long)|uniprotkb:Accessory protein 3b(gene name synonym)|uniprotkb:Protein X2(gene name synonym)|uniprotkb:3b(orf name)|uniprotkb:Non-structural protein 3b(gene name synonym) psi-mi:dctn2_human(display_long)|uniprotkb:Dynactin complex 50 kDa subunit(gene name synonym)|uniprotkb:50 kDa dynein-associated polypeptide(gene name synonym)|uniprotkb:p50 dynamitin(gene name synonym)|uniprotkb:DCTN2(gene name)|psi-mi:DCTN2(display_short)|uniprotkb:DCTN50(gene name synonym) psi-mi:"MI:0398"(two hybrid pooling approach) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25489017|imex:IM-27830-174 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001817"(regulation of cytokine production)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0039526"(modulation by virus of host apoptotic process)|go:"GO:0039646"(modulation by virus of host G0/G1 transition checkpoint)|go:"GO:0044196"(host cell nucleolus)|interpro:IPR022117|refseq:NP_828853.1 refseq:NP_006391.1|refseq:NP_001248341.1|refseq:NP_001248342.1|dip:DIP-37545N|reactome:R-HSA-2565942|reactome:R-HSA-3371497|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-6807878|reactome:R-HSA-6811436|reactome:R-HSA-8854518|ensembl:ENSG00000175203(gene)|ensembl:ENST00000548249(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005869"(dynactin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030286"(dynein complex)|go:"GO:0030426"(growth cone)|go:"GO:0030507"(spectrin binding)|go:"GO:0031982"(vesicle)|go:"GO:0032402"(melanosome transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071539"(protein localization to centrosome)|interpro:IPR028133|mint:Q13561|reactome:R-HSA-2132295 - - - figure legend:ST1|comment:"Library for Y2H screening used: fetal brain"|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/19 2020/03/31 rogid:EXisl4V+/e8ZhnQTLu6kcdKi4RE694009 rogid:JrL5jUtArek+zqmCkPKomnjuSf09606 rigid:uYUkOj6611qkK/z9gY8IC7Q0b48 false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P59633 uniprotkb:P05155 intact:EBI-25489004|uniprotkb:Q7TFA9|uniprotkb:Q80BV4 intact:EBI-1223454|uniprotkb:Q547W3|uniprotkb:Q59EI5|uniprotkb:Q96FE0|uniprotkb:A6NMU0|uniprotkb:A8KAI9|uniprotkb:B2R6L5|uniprotkb:Q16304|uniprotkb:Q7Z455|uniprotkb:Q9UC49|uniprotkb:Q9UCF9|uniprotkb:B4E1F0|uniprotkb:B4E1H2|ensembl:ENSP00000278407|ensembl:ENSP00000504807 psi-mi:ns3b_sars(display_long)|uniprotkb:Accessory protein 3b(gene name synonym)|uniprotkb:Protein X2(gene name synonym)|uniprotkb:3b(orf name)|uniprotkb:Non-structural protein 3b(gene name synonym) psi-mi:ic1_human(display_long)|uniprotkb:SERPING1(gene name)|psi-mi:SERPING1(display_short)|uniprotkb:C1IN(gene name synonym)|uniprotkb:C1NH(gene name synonym)|uniprotkb:C1 esterase inhibitor(gene name synonym)|uniprotkb:C1-inhibiting factor(gene name synonym)|uniprotkb:Serpin G1(gene name synonym) psi-mi:"MI:0398"(two hybrid pooling approach) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25489024|imex:IM-27830-176 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001817"(regulation of cytokine production)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0039526"(modulation by virus of host apoptotic process)|go:"GO:0039646"(modulation by virus of host G0/G1 transition checkpoint)|go:"GO:0044196"(host cell nucleolus)|interpro:IPR022117|refseq:NP_828853.1 refseq:NP_000053.2|refseq:NP_001027466.1|dip:DIP-45635N|ensembl:ENSG00000149131(gene)|ensembl:ENST00000278407(transcript)|ensembl:ENST00000676670(transcript)|go:"GO:0001869"(negative regulation of complement activation, lectin pathway)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0007568"(aging)|go:"GO:0007596"(blood coagulation)|go:"GO:0008015"(blood circulation)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0042730"(fibrinolysis)|go:"GO:0045087"(innate immune response)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR015553(Protease inhibitor I4, serpin C1)|interpro:IPR023795|interpro:IPR023796|interpro:IPR036186|interpro:IPR042178|interpro:IPR042185|mint:P05155|rcsb pdb:1M6Q|rcsb pdb:2OAY|rcsb pdb:5DU3|rcsb pdb:5DUQ|rcsb pdb:7AKV|reactome:R-HSA-114608|reactome:R-HSA-140837|reactome:R-HSA-9657689|reactome:R-HSA-977606 - - - figure legend:ST1|comment:"Library for Y2H screening used: fetal brain, ORFeome"|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/19 2020/03/31 rogid:EXisl4V+/e8ZhnQTLu6kcdKi4RE694009 rogid:Y7cqCZ6Ryz51dsi6jM86EXdfeWc9606 rigid:+D6Nc/YM/3wIMtdkgo5fiydvua0 false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P59633 uniprotkb:P02768 intact:EBI-25489004|uniprotkb:Q7TFA9|uniprotkb:Q80BV4 intact:EBI-714423|ensembl:ENSP00000295897|uniprotkb:Q645G4|uniprotkb:O95574|uniprotkb:P04277|uniprotkb:Q13140|uniprotkb:Q68DN5|uniprotkb:Q6UXK4|uniprotkb:Q86YG0|uniprotkb:Q9P157|uniprotkb:Q9P1I7|uniprotkb:Q9UHS3|uniprotkb:Q9UJZ0|intact:EBI-7301844|intact:MINT-1161169|uniprotkb:E7ESS9|uniprotkb:Q8IUK7 psi-mi:ns3b_sars(display_long)|uniprotkb:Accessory protein 3b(gene name synonym)|uniprotkb:Protein X2(gene name synonym)|uniprotkb:3b(orf name)|uniprotkb:Non-structural protein 3b(gene name synonym) psi-mi:albu_human(display_long)|uniprotkb:GIG42(orf name)|uniprotkb:ALB(gene name)|psi-mi:ALB(display_short)|uniprotkb:PRO0903(orf name)|uniprotkb:PRO1708(orf name)|uniprotkb:PRO2044(orf name)|uniprotkb:PRO2619(orf name)|uniprotkb:PRO2675(orf name)|uniprotkb:UNQ696/PRO1341(orf name)|uniprotkb:GIG20(orf name) psi-mi:"MI:0398"(two hybrid pooling approach) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25489031|imex:IM-27830-202 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001817"(regulation of cytokine production)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0039526"(modulation by virus of host apoptotic process)|go:"GO:0039646"(modulation by virus of host G0/G1 transition checkpoint)|go:"GO:0044196"(host cell nucleolus)|interpro:IPR022117|refseq:NP_828853.1 ensembl:ENSG00000163631(gene)|ensembl:ENST00000295897(transcript)|go:"GO:0001895"(retina homeostasis)|go:"GO:0003677"(DNA binding)|go:"GO:0005504"(fatty acid binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|rcsb pdb:1E78|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0015643"(toxic substance binding)|go:"GO:0016209"(antioxidant activity)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0051087"(chaperone binding)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0051659"(maintenance of mitochondrion location)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0140272"(exogenous protein binding)|go:"GO:1903981"(enterobactin binding)|interpro:IPR000264(Serum albumin)|interpro:IPR014760(Serum albumin, N-terminal)|interpro:IPR020857|interpro:IPR020858|interpro:IPR021177|mint:P02768|rcsb pdb:1AO6|rcsb pdb:1BJ5|rcsb pdb:1BKE|rcsb pdb:1BM0|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|rcsb pdb:6XV0|rcsb pdb:6YG9|rcsb pdb:6ZL1|rcsb pdb:7A9C|rcsb pdb:7AAE|rcsb pdb:7AAI|rcsb pdb:7D6J|rcsb pdb:7JWN|reactome:R-HSA-114608|reactome:R-HSA-159418|reactome:R-HSA-189451|reactome:R-HSA-189483|reactome:R-HSA-2168880|reactome:R-HSA-381426|reactome:R-HSA-879518|reactome:R-HSA-8957275|reactome:R-HSA-8964058|reactome:R-HSA-9707564|rcsb pdb:6WUW|rcsb pdb:1E7B|rcsb pdb:1E7C|rcsb pdb:1E7E|rcsb pdb:1E7F|rcsb pdb:1E7G|rcsb pdb:1E7H|rcsb pdb:1E7I|rcsb pdb:1GNI|rcsb pdb:1GNJ|rcsb pdb:1H9Z|rcsb pdb:1HA2|rcsb pdb:1HK1|rcsb pdb:1HK2|rcsb pdb:1HK3|rcsb pdb:1HK4|rcsb pdb:1HK5|rcsb pdb:1N5U|rcsb pdb:1O9X|rcsb pdb:1TF0|rcsb pdb:1UOR|rcsb pdb:1YSX|rcsb pdb:2BX8|rcsb pdb:2BXA|rcsb pdb:2BXB|rcsb pdb:2BXC|rcsb pdb:2BXD|rcsb pdb:1E7A|rcsb pdb:2BXE|rcsb pdb:2BXF|rcsb pdb:2BXG|rcsb pdb:2BXH|rcsb pdb:2BXI|rcsb pdb:2BXK|rcsb pdb:2BXL|rcsb pdb:2BXM|rcsb pdb:2BXN|rcsb pdb:2BXO|rcsb pdb:2BXP|rcsb pdb:2BXQ|rcsb pdb:2ESG|rcsb pdb:2I2Z|rcsb pdb:2I30|rcsb pdb:2N0X|rcsb pdb:2VDB|rcsb pdb:2VUE|rcsb pdb:2VUF|rcsb pdb:2XSI|rcsb pdb:2XVQ|rcsb pdb:2XVU|rcsb pdb:2XVV|rcsb pdb:2XVW|rcsb pdb:2XW0|rcsb pdb:2XW1|rcsb pdb:2YDF|rcsb pdb:3A73|rcsb pdb:3B9L|rcsb pdb:3B9M|rcsb pdb:3CX9|rcsb pdb:3JQZ|rcsb pdb:3JRY|rcsb pdb:3LU6|rcsb pdb:4HGM|rcsb pdb:4IW1|rcsb pdb:4IW2|rcsb pdb:4K2C|rcsb pdb:4K71|rcsb pdb:4L8U|rcsb pdb:4L9K|rcsb pdb:4L9Q|rcsb pdb:4LA0|rcsb pdb:4LB2|rcsb pdb:4LB9|rcsb pdb:4N0F|rcsb pdb:4N0U|rcsb pdb:4S1Y|rcsb pdb:4Z69|rcsb pdb:5FUO|rcsb pdb:5GIX|rcsb pdb:5GIY|rcsb pdb:5ID7|rcsb pdb:5IFO|rcsb pdb:5IJF|rcsb pdb:5UJB|rcsb pdb:5VNW|rcsb pdb:5X52|rcsb pdb:5YB1|rcsb pdb:5YOQ|rcsb pdb:5Z0B|rcsb pdb:6A7P|rcsb pdb:6EZQ|rcsb pdb:6HSC|rcsb pdb:6JE7|rcsb pdb:6L4K|rcsb pdb:6M4R|rcsb pdb:3LU7|rcsb pdb:3LU8|rcsb pdb:3SQJ|rcsb pdb:3TDL|rcsb pdb:3UIV|rcsb pdb:4BKE|rcsb pdb:4E99|rcsb pdb:4EMX|rcsb pdb:4G03|rcsb pdb:4G04|rcsb pdb:4HGK|rcsb pdb:6M58|rcsb pdb:6M5D|rcsb pdb:6M5E|rcsb pdb:6QIO|rcsb pdb:6QIP|rcsb pdb:6R7S|refseq:NP_000468.1|dip:DIP-29902N - - - figure legend:ST1|comment:"Library for Y2H screening used: ORFeome, fetal brain"|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/19 2020/03/31 rogid:EXisl4V+/e8ZhnQTLu6kcdKi4RE694009 rogid:kjtn5mBsCZz/NRkcyW5k3ZWeJBU9606 rigid:aBTUNkaEDm+VY+XIRkKnM1fJt9A false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q6S8E0 uniprotkb:P08708 intact:EBI-25489144|uniprotkb:Q19QV9 intact:EBI-358255|uniprotkb:B2R4U4|intact:EBI-8012092|intact:EBI-11603362|intact:MINT-8395037|uniprotkb:P0CW22|ensembl:ENSP00000483755|ensembl:ENSP00000498019 psi-mi:q6s8e0_sars(display_long)|uniprotkb:ORF9b(gene name)|psi-mi:ORF9b(display_short)|uniprotkb:sars9b(gene name synonym)|uniprotkb:ORF-9b(gene name synonym)|uniprotkb:Protein 9b(gene name synonym) psi-mi:rs17_human(display_long)|uniprotkb:RPS17(gene name)|psi-mi:RPS17(display_short)|uniprotkb:Small ribosomal subunit protein eS17(gene name synonym)|uniprotkb:RPS17L(gene name synonym) psi-mi:"MI:0398"(two hybrid pooling approach) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25489175|imex:IM-27830-92 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005737"(cytoplasm)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR018542|interpro:IPR037223|refseq:NP_828859.1 refseq:NP_001012.1|ensembl:ENSG00000182774(gene)|ensembl:ENSG00000278229(gene)|ensembl:ENST00000617731(transcript)|ensembl:ENST00000647841(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006364"(rRNA processing)|go:"GO:0006412"(translation)|go:"GO:0006413"(translational initiation)|go:"GO:0016020"(membrane)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0042274"(ribosomal small subunit biogenesis)|interpro:IPR001210(Ribosomal protein S17e)|interpro:IPR018273|interpro:IPR036401|mint:P08708|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|go:"GO:0034101"(erythrocyte homeostasis)|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBD|rcsb pdb:6YBS|rcsb pdb:6YBW|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOK|rcsb pdb:6ZOL|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957 - - - figure legend:ST1|comment:"Library for Y2H screening used: ORFeome"|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/19 2020/03/31 rogid:ZEzTkfwAYVAO0h/WLJJYeWYudyk694009 rogid:st+xQCXdSObiy6cJD1cSx869V289606 rigid:y966tIZyEizbNyYkmnFWk90OFPM false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q6S8E0 uniprotkb:P25787 intact:EBI-25489144|uniprotkb:Q19QV9 intact:EBI-603262|uniprotkb:Q9BU45|ensembl:ENSP00000223321|intact:EBI-1237095|uniprotkb:Q6ICS6 psi-mi:q6s8e0_sars(display_long)|uniprotkb:ORF9b(gene name)|psi-mi:ORF9b(display_short)|uniprotkb:sars9b(gene name synonym)|uniprotkb:ORF-9b(gene name synonym)|uniprotkb:Protein 9b(gene name synonym) psi-mi:psa2_human(display_long)|uniprotkb:PSMA2(gene name)|psi-mi:PSMA2(display_short)|uniprotkb:PSC3(gene name synonym)|uniprotkb:Proteasome component C3(gene name synonym)|uniprotkb:Macropain subunit C3(gene name synonym)|uniprotkb:Multicatalytic endopeptidase complex subunit C3(gene name synonym)|uniprotkb:HC3(gene name synonym) psi-mi:"MI:0398"(two hybrid pooling approach) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25489161|imex:IM-27830-246 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005737"(cytoplasm)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR018542|interpro:IPR037223|refseq:NP_828859.1 mint:P25787|rcsb pdb:4R3O|rcsb pdb:4R67|rcsb pdb:5A0Q|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LE5|rcsb pdb:5LEX|rcsb pdb:5LEY|rcsb pdb:5LEZ|rcsb pdb:5LF0|rcsb pdb:5LF1|rcsb pdb:5LF3|rcsb pdb:5LF4|rcsb pdb:5LF6|rcsb pdb:5LF7|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|ensembl:ENSG00000106588(gene)|ensembl:ENST00000223321(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0000932"(P-body)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005839"(proteasome core complex)|go:"GO:0009615"(response to virus)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0019773"(proteasome core complex, alpha-subunit complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000426(Proteasome alpha-subunit, conserved site)|interpro:IPR001353(20S proteasome, A and B subunits)|interpro:IPR023332|interpro:IPR029055|interpro:IPR034644|refseq:NP_002778.1|dip:DIP-29364N|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFO|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:6AVO|rcsb pdb:6E5B|rcsb pdb:6KWY|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6R70|rcsb pdb:6REY|rcsb pdb:6RGQ|rcsb pdb:6WJD|rcsb pdb:6WJN|rcsb pdb:6XMJ|rcsb pdb:7AWE|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168 - - - figure legend:ST1|comment:"Library for Y2H screening used: fetal brain"|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/19 2020/03/31 rogid:ZEzTkfwAYVAO0h/WLJJYeWYudyk694009 rogid:COncAMXXqT+zAHA/nK+7dweRg9A9606 rigid:gWbrpZeJcve8ImVq7xCmMx7VB6g false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P59634 uniprotkb:Q13561 intact:EBI-25489038|uniprotkb:Q7T6R9|uniprotkb:Q7TA25|uniprotkb:Q7TFA7|uniprotkb:Q80BV3 intact:EBI-715074|uniprotkb:Q86YN2|uniprotkb:Q9BW17|uniprotkb:B2RBK5|ensembl:ENSP00000447824 psi-mi:ns6_sars(display_long)|uniprotkb:Accessory protein 6(gene name synonym)|uniprotkb:Protein X3(gene name synonym)|uniprotkb:6(orf name)|uniprotkb:Non-structural protein 6(gene name synonym) psi-mi:dctn2_human(display_long)|uniprotkb:Dynactin complex 50 kDa subunit(gene name synonym)|uniprotkb:50 kDa dynein-associated polypeptide(gene name synonym)|uniprotkb:p50 dynamitin(gene name synonym)|uniprotkb:DCTN2(gene name)|psi-mi:DCTN2(display_short)|uniprotkb:DCTN50(gene name synonym) psi-mi:"MI:0398"(two hybrid pooling approach) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25489052|imex:IM-27830-242 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016020"(membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039563"(suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044178"(host cell Golgi membrane)|interpro:IPR022736|refseq:NP_828856.1 refseq:NP_006391.1|refseq:NP_001248341.1|refseq:NP_001248342.1|dip:DIP-37545N|reactome:R-HSA-2565942|reactome:R-HSA-3371497|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-6807878|reactome:R-HSA-6811436|reactome:R-HSA-8854518|ensembl:ENSG00000175203(gene)|ensembl:ENST00000548249(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005869"(dynactin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030286"(dynein complex)|go:"GO:0030426"(growth cone)|go:"GO:0030507"(spectrin binding)|go:"GO:0031982"(vesicle)|go:"GO:0032402"(melanosome transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071539"(protein localization to centrosome)|interpro:IPR028133|mint:Q13561|reactome:R-HSA-2132295 - - - figure legend:ST1|comment:"Library for Y2H screening used: fetal brain"|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/19 2020/03/31 rogid:FbI4KIsNxOBCtk9JMPiabQsxtXM694009 rogid:JrL5jUtArek+zqmCkPKomnjuSf09606 rigid:xPSMv6ZfJOEdAfEalOAr6JHrm74 false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P59634 uniprotkb:Q92994 intact:EBI-25489038|uniprotkb:Q7T6R9|uniprotkb:Q7TA25|uniprotkb:Q7TFA7|uniprotkb:Q80BV3 intact:EBI-949861|ensembl:ENSP00000448387|uniprotkb:Q13223|uniprotkb:Q5PR24|uniprotkb:Q6IQ02|uniprotkb:Q9HCW6|uniprotkb:Q9HCW7|uniprotkb:Q9HCW8|uniprotkb:Q3SYD9|uniprotkb:Q96KX3|uniprotkb:B4DIG5|uniprotkb:B3KU36|uniprotkb:B7Z2N3|uniprotkb:F5H5Z7|uniprotkb:F8WA46 psi-mi:ns6_sars(display_long)|uniprotkb:Accessory protein 6(gene name synonym)|uniprotkb:Protein X3(gene name synonym)|uniprotkb:6(orf name)|uniprotkb:Non-structural protein 6(gene name synonym) psi-mi:tf3b_human(display_long)|uniprotkb:B-related factor 1(gene name synonym)|uniprotkb:TATA box-binding protein-associated factor, RNA polymerase III, subunit 2(gene name synonym)|uniprotkb:BRF1(gene name)|psi-mi:BRF1(display_short)|uniprotkb:BRF(gene name synonym)|uniprotkb:GTF3B(gene name synonym)|uniprotkb:TAF3B2(gene name synonym)|uniprotkb:TAF3C(gene name synonym) psi-mi:"MI:0398"(two hybrid pooling approach) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25489059|imex:IM-27830-90 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016020"(membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039563"(suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044178"(host cell Golgi membrane)|interpro:IPR022736|refseq:NP_828856.1 go:"GO:0005654"(nucleoplasm)|go:"GO:0006352"(DNA-templated transcription, initiation)|go:"GO:0006383"(transcription by RNA polymerase III)|go:"GO:0006384"(transcription initiation from RNA polymerase III promoter)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009304"(tRNA transcription)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0046872"(metal ion binding)|go:"GO:0070897"(transcription preinitiation complex assembly)|go:"GO:0097550"(transcription preinitiation complex)|interpro:IPR000812(Transcription factor TFIIB related)|interpro:IPR011665(Brf1-like TBP-binding)|interpro:IPR013137(Zinc finger, TFIIB-type)|interpro:IPR013150(Transcription factor TFIIB, cyclin-related)|interpro:IPR013763(Cyclin-related)|interpro:IPR029529|interpro:IPR036915|reactome:R-HSA-749476|reactome:R-HSA-76061|reactome:R-HSA-76066|ensembl:ENSG00000185024(gene)|ensembl:ENST00000547530(transcript)|go:"GO:0000126"(transcription factor TFIIIB complex)|go:"GO:0000995"(RNA polymerase III general transcription initiation factor activity)|go:"GO:0001006"(RNA polymerase III type 3 promoter sequence-specific DNA binding)|go:"GO:0005634"(nucleus)|refseq:NP_001229715.1|refseq:NP_001229716.1|refseq:NP_001229717.1|refseq:NP_001229718.1|refseq:NP_001510.2|refseq:NP_663718.1|refseq:NP_001229719.1|refseq:XP_005267620.1 - - - figure legend:ST1|comment:"Library for Y2H screening used: fetal brain"|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/19 2020/03/31 rogid:FbI4KIsNxOBCtk9JMPiabQsxtXM694009 rogid:89DaAP5RNWeXBVWz3IGSJjm+Txo9606 rigid:Zvehg2SJB90E4WNBCUYGmOkpMPw false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q19QW4 uniprotkb:Q9BQB6 intact:EBI-25489066|uniprotkb:J9T0F7 intact:EBI-6256462|ensembl:ENSP00000378426|uniprotkb:A6NIQ6|uniprotkb:B2R4Z6|uniprotkb:Q6UX90|uniprotkb:Q7Z2R4 psi-mi:q19qw4_sars(display_long)|uniprotkb:ORF7a(gene name)|psi-mi:ORF7a(display_short) psi-mi:vkor1_human(display_long)|uniprotkb:VKORC1(gene name)|psi-mi:VKORC1(display_short)|uniprotkb:VKOR(gene name synonym)|uniprotkb:Vitamin K1 2,3-epoxide reductase subunit 1(gene name synonym)|uniprotkb:MSTP134(orf name)|uniprotkb:MSTP576(orf name)|uniprotkb:UNQ308/PRO351(orf name) psi-mi:"MI:0398"(two hybrid pooling approach) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25489075|imex:IM-27830-68 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR044871|go:"GO:0016021"(integral component of membrane)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0039646"(modulation by virus of host G0/G1 transition checkpoint)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044173"(host cell endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0044178"(host cell Golgi membrane)|interpro:IPR014888(SARS coronavirus X4 like)|interpro:IPR036495|refseq:NP_828857.1 ensembl:ENSG00000167397(gene)|ensembl:ENST00000394975(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0007596"(blood coagulation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017144"|go:"GO:0017187"(peptidyl-glutamic acid carboxylation)|go:"GO:0042373"(vitamin K metabolic process)|go:"GO:0047057"("vitamin-K-epoxide reductase (warfarin-sensitive) activity")|go:"GO:0048038"(quinone binding)|go:"GO:0060348"(bone development)|interpro:IPR012932(Vitamin K epoxide reductase)|interpro:IPR038354|interpro:IPR042406|mint:Q9BQB6|rcsb pdb:6WV3|rcsb pdb:6WV4|rcsb pdb:6WV5|rcsb pdb:6WV6|rcsb pdb:6WV7|rcsb pdb:6WVH|reactome:R-HSA-6806664|refseq:NP_001298240.1|refseq:NP_076869.1|refseq:NP_996560.1 - - - figure legend:ST1|comment:"Library for Y2H screening used: fetal brain"|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/19 2020/03/31 rogid:Es9fKGNXTAgB+97mHmPWTjXL8nU694009 rogid:C3RrQ+y7Huai7PExa9LOvfqni+U9606 rigid:esHBpOZyjDO5MRN77CDyzPNEmjs false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q19QW4 uniprotkb:Q9H4F8 intact:EBI-25489066|uniprotkb:J9T0F7 intact:EBI-2801103|uniprotkb:B2R7P5|uniprotkb:Q96F78|uniprotkb:A8K1S3|ensembl:ENSP00000370680 psi-mi:q19qw4_sars(display_long)|uniprotkb:ORF7a(gene name)|psi-mi:ORF7a(display_short) psi-mi:smoc1_human(display_long)|uniprotkb:Secreted modular calcium-binding protein 1(gene name synonym)|uniprotkb:SMOC1(gene name)|psi-mi:SMOC1(display_short) psi-mi:"MI:0398"(two hybrid pooling approach) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25489082|imex:IM-27830-128 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR044871|go:"GO:0016021"(integral component of membrane)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0039646"(modulation by virus of host G0/G1 transition checkpoint)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044173"(host cell endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0044178"(host cell Golgi membrane)|interpro:IPR014888(SARS coronavirus X4 like)|interpro:IPR036495|refseq:NP_828857.1 refseq:NP_001030024.1|refseq:NP_071420.1|ensembl:ENSG00000198732(gene)|ensembl:ENST00000381280(transcript)|go:"GO:0001654"(eye development)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0008201"(heparin binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0060173"(limb development)|interpro:IPR000716(Thyroglobulin type-1)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR019577|interpro:IPR036058|interpro:IPR036857|interpro:IPR037639 - - - figure legend:ST1|comment:"Library for Y2H screening used: fetal brain"|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/19 2020/03/31 rogid:Es9fKGNXTAgB+97mHmPWTjXL8nU694009 rogid:EA0b+kWuv4b9e19gotvuaTm3GE09606 rigid:J0jodP9ybP0dJWxsh207yUjdqeM false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q7T6S2 uniprotkb:P49069 intact:EBI-25489089|uniprotkb:Q19QW3|uniprotkb:Q6S8E4|uniprotkb:Q6T9E5|uniprotkb:Q7T695|uniprotkb:Q7T6Q7|uniprotkb:Q7T6R0|uniprotkb:Q7T6R4|uniprotkb:Q7T6R8|uniprotkb:Q7TA24 intact:EBI-1748958|uniprotkb:A1L3Y3|ensembl:ENSP00000297156 psi-mi:q7t6s2_sars(display_long)|uniprotkb:orf7b(gene name)|psi-mi:orf7b(display_short)|uniprotkb:NS7b(gene name synonym)|uniprotkb:sars7b(gene name synonym) psi-mi:camlg_human(display_long)|uniprotkb:CAMLG(gene name)|psi-mi:CAMLG(display_short)|uniprotkb:CAML(gene name synonym)|uniprotkb:Calcium signal-modulating cyclophilin ligand(gene name synonym)|uniprotkb:GET2(gene name synonym) psi-mi:"MI:0398"(two hybrid pooling approach) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25489107|imex:IM-27830-244 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016021"(integral component of membrane)|go:"GO:0033644"(host cell membrane)|interpro:IPR044394|interpro:IPR021532|refseq:NP_849175.1 refseq:NP_001736.1|ensembl:ENSG00000164615(gene)|ensembl:ENST00000297156(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006952"(defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0043529"(GET complex)|go:"GO:0050821"(protein stabilization)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|interpro:IPR016719(Calcium signal-modulating cyclophilin ligand)|rcsb pdb:6SO5|reactome:R-HSA-9609523 - - - figure legend:ST1|comment:"Library for Y2H screening used: fetal brain"|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/19 2020/03/31 rogid:Upm5Q0uPKGlq3LcK5EspPTD7Fc4694009 rogid:BUKJ1VPumP1iJJnr485rxWzEyK49606 rigid:eJMnw13uwgjlkVPIEQVe3UIg/N8 false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q7T6S2 uniprotkb:P05155 intact:EBI-25489089|uniprotkb:Q19QW3|uniprotkb:Q6S8E4|uniprotkb:Q6T9E5|uniprotkb:Q7T695|uniprotkb:Q7T6Q7|uniprotkb:Q7T6R0|uniprotkb:Q7T6R4|uniprotkb:Q7T6R8|uniprotkb:Q7TA24 intact:EBI-1223454|uniprotkb:Q547W3|uniprotkb:Q59EI5|uniprotkb:Q96FE0|uniprotkb:A6NMU0|uniprotkb:A8KAI9|uniprotkb:B2R6L5|uniprotkb:Q16304|uniprotkb:Q7Z455|uniprotkb:Q9UC49|uniprotkb:Q9UCF9|uniprotkb:B4E1F0|uniprotkb:B4E1H2|ensembl:ENSP00000278407|ensembl:ENSP00000504807 psi-mi:q7t6s2_sars(display_long)|uniprotkb:orf7b(gene name)|psi-mi:orf7b(display_short)|uniprotkb:NS7b(gene name synonym)|uniprotkb:sars7b(gene name synonym) psi-mi:ic1_human(display_long)|uniprotkb:SERPING1(gene name)|psi-mi:SERPING1(display_short)|uniprotkb:C1IN(gene name synonym)|uniprotkb:C1NH(gene name synonym)|uniprotkb:C1 esterase inhibitor(gene name synonym)|uniprotkb:C1-inhibiting factor(gene name synonym)|uniprotkb:Serpin G1(gene name synonym) psi-mi:"MI:0398"(two hybrid pooling approach) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25489114|imex:IM-27830-146 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016021"(integral component of membrane)|go:"GO:0033644"(host cell membrane)|interpro:IPR044394|interpro:IPR021532|refseq:NP_849175.1 refseq:NP_000053.2|refseq:NP_001027466.1|dip:DIP-45635N|ensembl:ENSG00000149131(gene)|ensembl:ENST00000278407(transcript)|ensembl:ENST00000676670(transcript)|go:"GO:0001869"(negative regulation of complement activation, lectin pathway)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0007568"(aging)|go:"GO:0007596"(blood coagulation)|go:"GO:0008015"(blood circulation)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0042730"(fibrinolysis)|go:"GO:0045087"(innate immune response)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR015553(Protease inhibitor I4, serpin C1)|interpro:IPR023795|interpro:IPR023796|interpro:IPR036186|interpro:IPR042178|interpro:IPR042185|mint:P05155|rcsb pdb:1M6Q|rcsb pdb:2OAY|rcsb pdb:5DU3|rcsb pdb:5DUQ|rcsb pdb:7AKV|reactome:R-HSA-114608|reactome:R-HSA-140837|reactome:R-HSA-9657689|reactome:R-HSA-977606 - - - figure legend:ST1|comment:"Library for Y2H screening used: fetal brain"|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/19 2020/03/31 rogid:Upm5Q0uPKGlq3LcK5EspPTD7Fc4694009 rogid:Y7cqCZ6Ryz51dsi6jM86EXdfeWc9606 rigid:+wDAMnfr4Yq2qaNctzm7TO/B4nM false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q6S8E0 uniprotkb:P60866 intact:EBI-25489144|uniprotkb:Q19QV9 intact:EBI-353105|uniprotkb:P17075|uniprotkb:Q5M8S9|uniprotkb:B2R4F4|uniprotkb:B4DW28|ensembl:ENSP00000009589|ensembl:ENSP00000427788|ensembl:ENSP00000503327|ensembl:ENSP00000504123|ensembl:ENSP00000504154|ensembl:ENSP00000504670 psi-mi:q6s8e0_sars(display_long)|uniprotkb:ORF9b(gene name)|psi-mi:ORF9b(display_short)|uniprotkb:sars9b(gene name synonym)|uniprotkb:ORF-9b(gene name synonym)|uniprotkb:Protein 9b(gene name synonym) psi-mi:rs20_human(display_long)|uniprotkb:RPS20(gene name)|psi-mi:RPS20(display_short)|uniprotkb:Small ribosomal subunit protein uS10(gene name synonym) psi-mi:"MI:0398"(two hybrid pooling approach) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25489168|imex:IM-27830-36 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005737"(cytoplasm)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR018542|interpro:IPR037223|refseq:NP_828859.1 refseq:NP_001014.1|refseq:NP_001139699.1|dip:DIP-31245N|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|ensembl:ENSG00000008988(gene)|ensembl:ENST00000009589(transcript)|ensembl:ENST00000521262(transcript)|ensembl:ENST00000676461(transcript)|ensembl:ENST00000676918(transcript)|ensembl:ENST00000678039(transcript)|ensembl:ENST00000678683(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0016020"(membrane)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0045202"(synapse)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:1901798"(positive regulation of signal transduction by p53 class mediator)|go:"GO:1990948"(ubiquitin ligase inhibitor activity)|interpro:IPR001848(Ribosomal protein S10)|interpro:IPR005729(Ribosomal protein S10, eukaryotic/archaeal)|interpro:IPR018268|interpro:IPR027486|interpro:IPR036838|mint:P60866|rcsb pdb:4UG0|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBS|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOL|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957 - - - figure legend:ST1|comment:"Library for Y2H screening used: fetal brain"|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/19 2020/03/31 rogid:ZEzTkfwAYVAO0h/WLJJYeWYudyk694009 rogid:6xNxX+eP59AOm0KraCysRHUqMFw9606 rigid:4MXZZQu4jzmxJhy+H890lIhoFvk false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q6S8E0 uniprotkb:P27448 intact:EBI-25489144|uniprotkb:Q19QV9 intact:EBI-707595|uniprotkb:O60219|uniprotkb:Q8TB41|uniprotkb:Q8WX83|uniprotkb:Q96RG1|uniprotkb:Q9UMY9|uniprotkb:Q9UN34|uniprotkb:Q86TT8|uniprotkb:A0A0A0MQR8|uniprotkb:A0A0A0MST9|uniprotkb:A0A0A0MT23|ensembl:ENSP00000411397 psi-mi:q6s8e0_sars(display_long)|uniprotkb:ORF9b(gene name)|psi-mi:ORF9b(display_short)|uniprotkb:sars9b(gene name synonym)|uniprotkb:ORF-9b(gene name synonym)|uniprotkb:Protein 9b(gene name synonym) psi-mi:mark3_human(display_long)|uniprotkb:Cdc25C-associated protein kinase 1(gene name synonym)|uniprotkb:C-TAK1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase p78(gene name synonym)|uniprotkb:Ser/Thr protein kinase PAR-1(gene name synonym)|uniprotkb:Protein kinase STK10(gene name synonym)|uniprotkb:MARK3(gene name)|psi-mi:MARK3(display_short)|uniprotkb:CTAK1(gene name synonym)|uniprotkb:EMK2(gene name synonym)|uniprotkb:ELKL motif kinase 2(gene name synonym) psi-mi:"MI:0398"(two hybrid pooling approach) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25489154|imex:IM-27830-188 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005737"(cytoplasm)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR018542|interpro:IPR037223|refseq:NP_828859.1 refseq:NP_001122390.2|refseq:NP_001122391.2|refseq:NP_001122392.2|refseq:NP_001122393.2|refseq:NP_002367.5|dip:DIP-34637N|ensembl:ENSG00000075413(gene)|ensembl:ENST00000429436(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030425"(dendrite)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0048156"(tau protein binding)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001772(Kinase-associated KA1)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|interpro:IPR033628|mint:P27448|rcsb pdb:2QNJ|rcsb pdb:3FE3|rcsb pdb:7O94|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223 - - - figure legend:ST1|comment:"Library for Y2H screening used: fetal brain"|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/19 2020/03/31 rogid:ZEzTkfwAYVAO0h/WLJJYeWYudyk694009 rogid:YoMdp32OqT0OCgUUBwxSEHmA+vs9606 rigid:VIwBKf7RysHGpB3rQkcPvOP5LIo false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q19QW2 uniprotkb:P46379 intact:EBI-25489121|uniprotkb:Q6S8E3|uniprotkb:Q6T9E4|uniprotkb:Q7T694|uniprotkb:Q7T6Q6|uniprotkb:Q7T6Q9|uniprotkb:Q7T6R3|uniprotkb:Q7T6R7|uniprotkb:Q7T6S1|uniprotkb:Q7TA23 intact:EBI-347552|uniprotkb:A2ADJ7|uniprotkb:A3KQ42|uniprotkb:A3KQ44|uniprotkb:A6NGY6|uniprotkb:A6PWF7|uniprotkb:O95874|uniprotkb:Q5HYL9|uniprotkb:Q5SQ35|uniprotkb:Q5SQ36|uniprotkb:Q5SQ37|uniprotkb:Q5SQ41|uniprotkb:Q5SRP8|uniprotkb:Q5SRP9|uniprotkb:Q5STC1|uniprotkb:Q5STX1|uniprotkb:Q5STX3|uniprotkb:Q96SA6|uniprotkb:Q9BCN4|uniprotkb:B0UX84|uniprotkb:B4DZ12|uniprotkb:B4E3V4|uniprotkb:E7EMZ4|uniprotkb:F8VXY4|ensembl:ENSP00000354368|ensembl:ENSP00000390966|ensembl:ENSP00000397894 psi-mi:q19qw2_sars(display_long)|uniprotkb:orf8a(gene name)|psi-mi:orf8a(display_short)|uniprotkb:sars8a(gene name synonym) psi-mi:bag6_human(display_long)|uniprotkb:BAT3(gene name synonym)|uniprotkb:G3(gene name synonym)|uniprotkb:HLA-B-associated transcript 3(gene name synonym)|uniprotkb:Protein G3(gene name synonym)|uniprotkb:BCL2-associated athanogene 6(gene name synonym)|uniprotkb:BAG6(gene name)|psi-mi:BAG6(display_short)|uniprotkb:BAG family molecular chaperone regulator 6(gene name synonym)|uniprotkb:Protein Scythe(gene name synonym) psi-mi:"MI:0398"(two hybrid pooling approach) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25489137|imex:IM-27830-70 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR022722|refseq:NP_849176.1 dip:DIP-31191N|refseq:NP_001092004.1|refseq:NP_001186627.1|refseq:NP_004630.3|refseq:NP_542433.1|refseq:NP_542434.1|refseq:NP_001186626.1|refseq:XP_016866776.1|ensembl:ENSG00000096155(gene)|ensembl:ENSG00000229524(gene)|ensembl:ENSG00000233348(gene)|ensembl:ENST00000361076(transcript)|ensembl:ENST00000449450(transcript)|ensembl:ENST00000451932(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0002429"(immune response-activating cell surface receptor signaling pathway)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016020"(membrane)|go:"GO:0018393"(internal peptidyl-lysine acetylation)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0043022"(ribosome binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0050821"(protein stabilization)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0061857"(endoplasmic reticulum stress-induced pre-emptive quality control)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070628"(proteasome binding)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0071818"(BAT3 complex)|go:"GO:1904294"(positive regulation of ERAD pathway)|go:"GO:1904378"(maintenance of unfolded protein involved in ERAD pathway)|go:"GO:1904379"(protein localization to cytosolic proteasome complex involved in ERAD pathway)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR019954|interpro:IPR021925|interpro:IPR029071|mint:P46379|rcsb pdb:1WX9|rcsb pdb:2N9P|rcsb pdb:4DWF|rcsb pdb:4EEW|rcsb pdb:4WWR|rcsb pdb:6AU8|reactome:R-HSA-9609523|rcsb pdb:4X86 - - - figure legend:ST1|comment:"Library for Y2H screening used: fetal brain"|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/19 2020/03/31 rogid:Qi1RZccwqrBJVwiaxXlOG6EDqIk694009 rogid:ghHlLBbS3yeP2mN6AOoHs+CECKU9606 rigid:DOsY24+PiYDgxLstYMv3GU9XtVk false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P62937 uniprotkb:P0C6X7-PRO_0000037309 intact:EBI-437708|uniprotkb:P05092|uniprotkb:Q3KQW3|uniprotkb:Q6IBU5|uniprotkb:Q96IX3|uniprotkb:Q9BRU4|uniprotkb:Q9BTY9|uniprotkb:Q9UC61|uniprotkb:Q567Q0|ensembl:ENSP00000419425|uniprotkb:A8K220 intact:EBI-25475797 psi-mi:ppia_human(display_long)|uniprotkb:Cyclophilin A(gene name synonym)|uniprotkb:Cyclosporin A-binding protein(gene name synonym)|uniprotkb:PPIA(gene name)|psi-mi:PPIA(display_short)|uniprotkb:CYPA(gene name synonym)|uniprotkb:Rotamase A(gene name synonym) psi-mi:p0c6x7-pro_0000037309(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25475803|imex:IM-27830-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_066953.1|interpro:IPR029000|mint:P62937|rcsb pdb:1AK4|rcsb pdb:1AWQ|rcsb pdb:1AWR|rcsb pdb:1AWS|rcsb pdb:1AWT|rcsb pdb:1AWU|rcsb pdb:1AWV|rcsb pdb:1BCK|rcsb pdb:1CWA|rcsb pdb:1CWB|rcsb pdb:1CWC|rcsb pdb:1CWF|rcsb pdb:1CWH|rcsb pdb:1CWI|rcsb pdb:1CWJ|rcsb pdb:1CWK|rcsb pdb:1CWL|rcsb pdb:1CWM|interpro:IPR024936|rcsb pdb:1CWO|rcsb pdb:1FGL|rcsb pdb:2N0T|rcsb pdb:2RMA|rcsb pdb:1M63|rcsb pdb:2RMB|rcsb pdb:2X25|rcsb pdb:2X2A|rcsb pdb:2X2C|rcsb pdb:2X2D|rcsb pdb:1M9C|rcsb pdb:1M9D|rcsb pdb:1M9E|rcsb pdb:2XGY|rcsb pdb:3CYH|rcsb pdb:3CYS|rcsb pdb:3K0M|rcsb pdb:3K0N|rcsb pdb:3K0O|rcsb pdb:3K0P|rcsb pdb:3K0Q|rcsb pdb:3K0R|rcsb pdb:3ODI|rcsb pdb:3ODL|rcsb pdb:1M9F|rcsb pdb:3RDD|rcsb pdb:1M9X|rcsb pdb:1M9Y|rcsb pdb:4CYH|rcsb pdb:4IPZ|rcsb pdb:4N1M|rcsb pdb:4N1N|rcsb pdb:1MF8|rcsb pdb:4N1O|rcsb pdb:4N1P|rcsb pdb:4N1Q|rcsb pdb:1MIK|rcsb pdb:1NMK|rcsb pdb:1OCA|rcsb pdb:1RMH|rcsb pdb:1VBS|rcsb pdb:1VBT|rcsb pdb:1W8L|rcsb pdb:1W8M|rcsb pdb:1W8V|rcsb pdb:1YND|rcsb pdb:1ZKF|rcsb pdb:2ALF|rcsb pdb:2CPL|rcsb pdb:2CYH|rcsb pdb:2MS4|rcsb pdb:2MZU|rcsb pdb:4N1R|rcsb pdb:4N1S|rcsb pdb:4YUG|rcsb pdb:4YUH|refseq:NP_001287910.1|reactome:R-HSA-210991|reactome:R-HSA-6798695|reactome:R-HSA-8950505|reactome:R-HSA-2025928|ensembl:ENSG00000196262(gene)|ensembl:ENST00000468812(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006457"(protein folding)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006915"(apoptotic process)|go:"GO:0016018"(cyclosporin A binding)|go:"GO:0016020"(membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0030168"(platelet activation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031982"(vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032873"(negative regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034389"(lipid droplet organization)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045069"(regulation of viral genome replication)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046790"(virion binding)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060352"(cell adhesion molecule production)|go:"GO:0061944"(negative regulation of protein K48-linked ubiquitination)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903901"(negative regulation of viral life cycle)|go:"GO:1904399"(heparan sulfate binding)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2001233"(regulation of apoptotic signaling pathway)|interpro:IPR002130(Peptidyl-prolyl cis-trans isomerase, cyclophilin-type)|interpro:IPR020892|go:"GO:0005178"(integrin binding)|rcsb pdb:4YUI|rcsb pdb:4YUJ|rcsb pdb:4YUK|rcsb pdb:4YUL|rcsb pdb:4YUM|rcsb pdb:4YUN|rcsb pdb:4YUO|rcsb pdb:4YUP|rcsb pdb:5CYH|rcsb pdb:5F66|rcsb pdb:5FJB|rcsb pdb:5KUL|rcsb pdb:5KUN|rcsb pdb:5KUO|rcsb pdb:5KUQ|rcsb pdb:5KUR|rcsb pdb:5KUS|rcsb pdb:5KUU|rcsb pdb:5KUV|rcsb pdb:5KUW|rcsb pdb:5KUZ|rcsb pdb:5KV0|rcsb pdb:5KV1|rcsb pdb:5KV2|rcsb pdb:5KV3|rcsb pdb:5KV4|rcsb pdb:5KV5|rcsb pdb:5KV6|rcsb pdb:5KV7|rcsb pdb:5LUD|rcsb pdb:5NOQ|rcsb pdb:5NOR|rcsb pdb:5NOT|rcsb pdb:5NOU|rcsb pdb:5NOV|rcsb pdb:5NOW|rcsb pdb:5NOX|rcsb pdb:5NOY|rcsb pdb:5NOZ|rcsb pdb:5T9U|rcsb pdb:5T9W|rcsb pdb:5T9Z|rcsb pdb:5TA2|rcsb pdb:5TA4|rcsb pdb:5WC7|rcsb pdb:6BTA|rcsb pdb:6GJI|rcsb pdb:6GJJ|rcsb pdb:6GJL|rcsb pdb:6GJM|rcsb pdb:6GJN|rcsb pdb:6GJP|rcsb pdb:6GJR|rcsb pdb:6GJY|rcsb pdb:6GS6|rcsb pdb:6I42|rcsb pdb:6U5C|rcsb pdb:6U5D|rcsb pdb:6U5E|rcsb pdb:6U5G|rcsb pdb:6X3R|rcsb pdb:6X3Y|rcsb pdb:5NOS|rcsb pdb:6X4N|rcsb pdb:6X4O|rcsb pdb:6X4P|rcsb pdb:6X4Q|rcsb pdb:6Y9V|rcsb pdb:6Y9W|rcsb pdb:6Y9X|rcsb pdb:6Y9Y|rcsb pdb:6Y9Z|rcsb pdb:6ZDJ|rcsb pdb:7ABT|reactome:R-HSA-114608|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-173107|rcsb pdb:6X4M|reactome:R-HSA-175474|reactome:R-HSA-180689|dip:DIP-6080N intact:EBI-7843867(chain-parent)|uniprotkb:P0C6X7(chain-parent) - - chain-seq-start:1|chain-seq-end:180 figure legend:F3A|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2020/03/19 2020/03/24 rogid:dr4EVxcO+sqTPBqsQcydRn+rHoo9606 rogid:qbwEpGmE3J035KnL6QbEZ/HRJAw694009 rigid:XX/pCBj3HQy8hQeRejP0dbpwzRQ false renilla luciferase protein tag:n-n protein a tag:n-n|necessary binding region:1-93 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P23284 uniprotkb:P0C6X7-PRO_0000037309 intact:EBI-359252|uniprotkb:Q9BVK5|uniprotkb:A8K534|uniprotkb:Q6IBH5|ensembl:ENSP00000300026 intact:EBI-25475797 psi-mi:ppib_human(display_long)|uniprotkb:PPIB(gene name)|psi-mi:PPIB(display_short)|uniprotkb:CYPB(gene name synonym)|uniprotkb:Cyclophilin B(gene name synonym)|uniprotkb:S-cyclophilin(gene name synonym)|uniprotkb:CYP-S1(gene name synonym)|uniprotkb:Rotamase B(gene name synonym) psi-mi:p0c6x7-pro_0000037309(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25475813|imex:IM-27830-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000933.1|ensembl:ENSG00000166794(gene)|ensembl:ENST00000300026(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003723"(RNA binding)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005925"(focal adhesion)|go:"GO:0006457"(protein folding)|go:"GO:0016018"(cyclosporin A binding)|go:"GO:0016020"(membrane)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042470"(melanosome)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060348"(bone development)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070063"(RNA polymerase binding)|interpro:IPR002130(Peptidyl-prolyl cis-trans isomerase, cyclophilin-type)|interpro:IPR020892|interpro:IPR029000|mint:P23284|rcsb pdb:1CYN|rcsb pdb:3ICH|rcsb pdb:3ICI|reactome:R-HSA-1650814 intact:EBI-7843867(chain-parent)|uniprotkb:P0C6X7(chain-parent) - - chain-seq-start:1|chain-seq-end:180 figure legend:F3A|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2020/03/19 2020/03/24 rogid:h6nKaPUyEYUctYuu/3XfFhM4y9c9606 rogid:qbwEpGmE3J035KnL6QbEZ/HRJAw694009 rigid:akp19BdROHdTZ6kWMOvf3TxwhPg false protein a tag:n-n renilla luciferase protein tag:n-n|necessary binding region:1-93 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q13427 uniprotkb:P0C6X7-PRO_0000037309 intact:EBI-396072|uniprotkb:O00706|uniprotkb:Q96DG9|uniprotkb:Q53R40|uniprotkb:Q53SN4|ensembl:ENSP00000260970|ensembl:ENSP00000407083|ensembl:ENSP00000408683|ensembl:ENSP00000502997|ensembl:ENSP00000503136|ensembl:ENSP00000503525|uniprotkb:D3DPC5|uniprotkb:D3DPC6 intact:EBI-25475797 psi-mi:ppig_human(display_long)|uniprotkb:PPIG(gene name)|psi-mi:PPIG(display_short)|uniprotkb:Cyclophilin G(gene name synonym)|uniprotkb:Clk-associating RS-cyclophilin(gene name synonym)|uniprotkb:CASP10(gene name synonym)|uniprotkb:Rotamase G(gene name synonym) psi-mi:p0c6x7-pro_0000037309(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25488087|imex:IM-27830-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004783.2|ensembl:ENSG00000138398(gene)|ensembl:ENST00000260970(transcript)|ensembl:ENST00000433207(transcript)|ensembl:ENST00000448752(transcript)|ensembl:ENST00000676756(transcript)|ensembl:ENST00000678499(transcript)|ensembl:ENST00000679107(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003723"(RNA binding)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008380"(RNA splicing)|go:"GO:0016018"(cyclosporin A binding)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR002130(Peptidyl-prolyl cis-trans isomerase, cyclophilin-type)|interpro:IPR020892|interpro:IPR029000|mint:Q13427|rcsb pdb:2GW2|rcsb pdb:2WFI|rcsb pdb:2WFJ|rcsb pdb:5YZG|go:"GO:0006457"(protein folding)|refseq:XP_005247023.1|refseq:XP_005247024.1 intact:EBI-7843867(chain-parent)|uniprotkb:P0C6X7(chain-parent) - - chain-seq-start:1|chain-seq-end:180 figure legend:F3A|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2020/03/19 2020/03/25 rogid:gp1Pqv5G8E+PrPmp+BtUSSIkD/89606 rogid:qbwEpGmE3J035KnL6QbEZ/HRJAw694009 rigid:sqdrig/dgD9sPMytUqoSAGDUpY8 false protein a tag:n-n renilla luciferase protein tag:n-n|necessary binding region:1-93 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O43447 uniprotkb:P0C6X7-PRO_0000037309 intact:EBI-1055615|intact:EBI-6190037|uniprotkb:A6NNE7|ensembl:ENSP00000503384|ensembl:ENSP00000503489|ensembl:ENSP00000503922|ensembl:ENSP00000504108|ensembl:ENSP00000504595|ensembl:ENSP00000361630|ensembl:ENSP00000306614 intact:EBI-25475797 psi-mi:ppih_human(display_long)|uniprotkb:U-snRNP-associated cyclophilin SnuCyp-20(gene name synonym)|uniprotkb:Small nuclear ribonucleoprotein particle-specific cyclophilin H(gene name synonym)|uniprotkb:PPIH(gene name)|psi-mi:PPIH(display_short)|uniprotkb:CYP20(gene name synonym)|uniprotkb:CYPH(gene name synonym)|uniprotkb:Rotamase H(gene name synonym) psi-mi:p0c6x7-pro_0000037309(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25488097|imex:IM-27830-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006338.1|refseq:XP_005270419.1|ensembl:ENST00000304979(transcript)|ensembl:ENST00000372550(transcript)|ensembl:ENST00000676675(transcript)|ensembl:ENST00000677900(transcript)|ensembl:ENST00000678038(transcript)|ensembl:ENST00000678333(transcript)|ensembl:ENST00000678803(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006457"(protein folding)|go:"GO:0016018"(cyclosporin A binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071001"(U4/U6 snRNP)|interpro:IPR002130(Peptidyl-prolyl cis-trans isomerase, cyclophilin-type)|interpro:IPR020892|interpro:IPR024936|interpro:IPR029000|mint:O43447|rcsb pdb:1MZW|rcsb pdb:1QOI|rcsb pdb:5O9Z|rcsb pdb:6AHD|reactome:R-HSA-72163|ensembl:ENSG00000171960(gene)|refseq:NP_001317439.1|refseq:XP_016855546.1|refseq:XP_016855547.1|refseq:XP_016855548.1 intact:EBI-7843867(chain-parent)|uniprotkb:P0C6X7(chain-parent) - - chain-seq-start:1|chain-seq-end:180 figure legend:F3A|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2020/03/19 2020/03/25 rogid:6gE98w/LLmT7FlCBnaBDk+GWvQU9606 rogid:qbwEpGmE3J035KnL6QbEZ/HRJAw694009 rigid:qq/wuv0iWQs0JoZye2WztzC4oPo false protein a tag:n-n renilla luciferase protein tag:n-n|necessary binding region:1-93 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P0C6X7-PRO_0000037309 uniprotkb:P62942 intact:EBI-25475797 intact:EBI-1027571|uniprotkb:P20071|uniprotkb:Q4VC47|uniprotkb:Q6FGD9|uniprotkb:Q6LEU3|uniprotkb:Q9H103|uniprotkb:Q9H566|uniprotkb:D3DVW6|ensembl:ENSP00000371138|ensembl:ENSP00000371143|ensembl:ENSP00000383003|ensembl:ENSP00000503033|ensembl:ENSP00000503152 psi-mi:p0c6x7-pro_0000037309(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:fkb1a_human(display_long)|uniprotkb:FKBP1A(gene name)|psi-mi:FKBP1A(display_short)|uniprotkb:FKBP1(gene name synonym)|uniprotkb:FKBP12(gene name synonym)|uniprotkb:FK506-binding protein 1A(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:Immunophilin FKBP12(gene name synonym)|uniprotkb:12 kDa FK506-binding protein(gene name synonym)|uniprotkb:Calstabin-1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25488107|imex:IM-27830-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7843867(chain-parent)|uniprotkb:P0C6X7(chain-parent) ensembl:ENSG00000088832(gene)|ensembl:ENST00000381719(transcript)|ensembl:ENST00000381724(transcript)|ensembl:ENST00000400137(transcript)|ensembl:ENST00000677335(transcript)|ensembl:ENST00000678408(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005527"(macrolide binding)|go:"GO:0005528"(FK506 binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006458"('de novo' protein folding)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0014802"(terminal cisterna)|go:"GO:0016020"(membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0030018"(Z disc)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031312"(extrinsic component of organelle membrane)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032925"(regulation of activin receptor signaling pathway)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0042026"(protein refolding)|go:"GO:0042110"(T cell activation)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0046332"(SMAD binding)|go:"GO:0048185"(activin binding)|go:"GO:0050776"(regulation of immune response)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0060347"(heart trabecula formation)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0098562"(cytoplasmic side of membrane)|go:"GO:1902991"(regulation of amyloid precursor protein catabolic process)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990425"(ryanodine receptor complex)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|rcsb pdb:1A7X|rcsb pdb:1B6C|rcsb pdb:1BKF|rcsb pdb:1BL4|rcsb pdb:1D6O|rcsb pdb:1D7H|rcsb pdb:1D7I|rcsb pdb:1D7J|rcsb pdb:1EYM|rcsb pdb:1F40|rcsb pdb:1FAP|rcsb pdb:1FKB|rcsb pdb:1FKD|rcsb pdb:1FKF|rcsb pdb:1FKG|rcsb pdb:1FKH|rcsb pdb:1FKI|rcsb pdb:2DG4|rcsb pdb:2DG9|rcsb pdb:2FAP|rcsb pdb:2FKE|rcsb pdb:2ND5|rcsb pdb:2PPN|rcsb pdb:2PPO|rcsb pdb:2PPP|rcsb pdb:2RSE|rcsb pdb:3FAP|rcsb pdb:1FKJ|rcsb pdb:3H9R|rcsb pdb:3MDY|rcsb pdb:4DH0|rcsb pdb:4FAP|rcsb pdb:1FKR|rcsb pdb:4IPX|rcsb pdb:4N19|rcsb pdb:4ODP|rcsb pdb:4ODQ|rcsb pdb:4ODR|rcsb pdb:5I7P|rcsb pdb:5I7Q|rcsb pdb:6I1S|rcsb pdb:1FKS|rcsb pdb:6M4U|rcsb pdb:6OQA|rcsb pdb:6VCU|rcsb pdb:6YF0|rcsb pdb:6YF1|rcsb pdb:6YF2|rcsb pdb:6YF3|reactome:R-HSA-166208|rcsb pdb:1FKT|reactome:R-HSA-2025928|reactome:R-HSA-2173789|reactome:R-HSA-2173791|reactome:R-HSA-3656535|rcsb pdb:1J4H|rcsb pdb:1J4I|reactome:R-HSA-9679191|rcsb pdb:1J4R|rcsb pdb:1NSG|rcsb pdb:1QPF|rcsb pdb:1QPL|rcsb pdb:2DG3|refseq:NP_000792.1|refseq:NP_463460.1|dip:DIP-29710N - chain-seq-start:1|chain-seq-end:180 - figure legend:F3A|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2020/03/19 2020/03/25 rogid:qbwEpGmE3J035KnL6QbEZ/HRJAw694009 rogid:3eikHNIIVs8AFM7PYVWurI/9KUY9606 rigid:12k3v6POf9dqKbeZN+eWt1BHJNc false renilla luciferase protein tag:n-n|necessary binding region:1-93 protein a tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P62937 uniprotkb:P0C6X7-PRO_0000037309 intact:EBI-437708|uniprotkb:P05092|uniprotkb:Q3KQW3|uniprotkb:Q6IBU5|uniprotkb:Q96IX3|uniprotkb:Q9BRU4|uniprotkb:Q9BTY9|uniprotkb:Q9UC61|uniprotkb:Q567Q0|ensembl:ENSP00000419425|uniprotkb:A8K220 intact:EBI-25475797 psi-mi:ppia_human(display_long)|uniprotkb:Cyclophilin A(gene name synonym)|uniprotkb:Cyclosporin A-binding protein(gene name synonym)|uniprotkb:PPIA(gene name)|psi-mi:PPIA(display_short)|uniprotkb:CYPA(gene name synonym)|uniprotkb:Rotamase A(gene name synonym) psi-mi:p0c6x7-pro_0000037309(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25488229|imex:IM-27830-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_066953.1|interpro:IPR029000|mint:P62937|rcsb pdb:1AK4|rcsb pdb:1AWQ|rcsb pdb:1AWR|rcsb pdb:1AWS|rcsb pdb:1AWT|rcsb pdb:1AWU|rcsb pdb:1AWV|rcsb pdb:1BCK|rcsb pdb:1CWA|rcsb pdb:1CWB|rcsb pdb:1CWC|rcsb pdb:1CWF|rcsb pdb:1CWH|rcsb pdb:1CWI|rcsb pdb:1CWJ|rcsb pdb:1CWK|rcsb pdb:1CWL|rcsb pdb:1CWM|interpro:IPR024936|rcsb pdb:1CWO|rcsb pdb:1FGL|rcsb pdb:2N0T|rcsb pdb:2RMA|rcsb pdb:1M63|rcsb pdb:2RMB|rcsb pdb:2X25|rcsb pdb:2X2A|rcsb pdb:2X2C|rcsb pdb:2X2D|rcsb pdb:1M9C|rcsb pdb:1M9D|rcsb pdb:1M9E|rcsb pdb:2XGY|rcsb pdb:3CYH|rcsb pdb:3CYS|rcsb pdb:3K0M|rcsb pdb:3K0N|rcsb pdb:3K0O|rcsb pdb:3K0P|rcsb pdb:3K0Q|rcsb pdb:3K0R|rcsb pdb:3ODI|rcsb pdb:3ODL|rcsb pdb:1M9F|rcsb pdb:3RDD|rcsb pdb:1M9X|rcsb pdb:1M9Y|rcsb pdb:4CYH|rcsb pdb:4IPZ|rcsb pdb:4N1M|rcsb pdb:4N1N|rcsb pdb:1MF8|rcsb pdb:4N1O|rcsb pdb:4N1P|rcsb pdb:4N1Q|rcsb pdb:1MIK|rcsb pdb:1NMK|rcsb pdb:1OCA|rcsb pdb:1RMH|rcsb pdb:1VBS|rcsb pdb:1VBT|rcsb pdb:1W8L|rcsb pdb:1W8M|rcsb pdb:1W8V|rcsb pdb:1YND|rcsb pdb:1ZKF|rcsb pdb:2ALF|rcsb pdb:2CPL|rcsb pdb:2CYH|rcsb pdb:2MS4|rcsb pdb:2MZU|rcsb pdb:4N1R|rcsb pdb:4N1S|rcsb pdb:4YUG|rcsb pdb:4YUH|refseq:NP_001287910.1|reactome:R-HSA-210991|reactome:R-HSA-6798695|reactome:R-HSA-8950505|reactome:R-HSA-2025928|ensembl:ENSG00000196262(gene)|ensembl:ENST00000468812(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006457"(protein folding)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006915"(apoptotic process)|go:"GO:0016018"(cyclosporin A binding)|go:"GO:0016020"(membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0030168"(platelet activation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031982"(vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032873"(negative regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034389"(lipid droplet organization)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045069"(regulation of viral genome replication)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046790"(virion binding)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060352"(cell adhesion molecule production)|go:"GO:0061944"(negative regulation of protein K48-linked ubiquitination)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903901"(negative regulation of viral life cycle)|go:"GO:1904399"(heparan sulfate binding)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2001233"(regulation of apoptotic signaling pathway)|interpro:IPR002130(Peptidyl-prolyl cis-trans isomerase, cyclophilin-type)|interpro:IPR020892|go:"GO:0005178"(integrin binding)|rcsb pdb:4YUI|rcsb pdb:4YUJ|rcsb pdb:4YUK|rcsb pdb:4YUL|rcsb pdb:4YUM|rcsb pdb:4YUN|rcsb pdb:4YUO|rcsb pdb:4YUP|rcsb pdb:5CYH|rcsb pdb:5F66|rcsb pdb:5FJB|rcsb pdb:5KUL|rcsb pdb:5KUN|rcsb pdb:5KUO|rcsb pdb:5KUQ|rcsb pdb:5KUR|rcsb pdb:5KUS|rcsb pdb:5KUU|rcsb pdb:5KUV|rcsb pdb:5KUW|rcsb pdb:5KUZ|rcsb pdb:5KV0|rcsb pdb:5KV1|rcsb pdb:5KV2|rcsb pdb:5KV3|rcsb pdb:5KV4|rcsb pdb:5KV5|rcsb pdb:5KV6|rcsb pdb:5KV7|rcsb pdb:5LUD|rcsb pdb:5NOQ|rcsb pdb:5NOR|rcsb pdb:5NOT|rcsb pdb:5NOU|rcsb pdb:5NOV|rcsb pdb:5NOW|rcsb pdb:5NOX|rcsb pdb:5NOY|rcsb pdb:5NOZ|rcsb pdb:5T9U|rcsb pdb:5T9W|rcsb pdb:5T9Z|rcsb pdb:5TA2|rcsb pdb:5TA4|rcsb pdb:5WC7|rcsb pdb:6BTA|rcsb pdb:6GJI|rcsb pdb:6GJJ|rcsb pdb:6GJL|rcsb pdb:6GJM|rcsb pdb:6GJN|rcsb pdb:6GJP|rcsb pdb:6GJR|rcsb pdb:6GJY|rcsb pdb:6GS6|rcsb pdb:6I42|rcsb pdb:6U5C|rcsb pdb:6U5D|rcsb pdb:6U5E|rcsb pdb:6U5G|rcsb pdb:6X3R|rcsb pdb:6X3Y|rcsb pdb:5NOS|rcsb pdb:6X4N|rcsb pdb:6X4O|rcsb pdb:6X4P|rcsb pdb:6X4Q|rcsb pdb:6Y9V|rcsb pdb:6Y9W|rcsb pdb:6Y9X|rcsb pdb:6Y9Y|rcsb pdb:6Y9Z|rcsb pdb:6ZDJ|rcsb pdb:7ABT|reactome:R-HSA-114608|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-173107|rcsb pdb:6X4M|reactome:R-HSA-175474|reactome:R-HSA-180689|dip:DIP-6080N intact:EBI-7843867(chain-parent)|uniprotkb:P0C6X7(chain-parent) - - chain-seq-start:1|chain-seq-end:180 figure legend:F3A|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2020/03/19 2020/03/25 rogid:dr4EVxcO+sqTPBqsQcydRn+rHoo9606 rogid:qbwEpGmE3J035KnL6QbEZ/HRJAw694009 rigid:XX/pCBj3HQy8hQeRejP0dbpwzRQ false protein a tag:n-n renilla luciferase protein tag:n-n|necessary binding region:1-93 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q13427 uniprotkb:P0C6X7-PRO_0000037309 intact:EBI-396072|uniprotkb:O00706|uniprotkb:Q96DG9|uniprotkb:Q53R40|uniprotkb:Q53SN4|ensembl:ENSP00000260970|ensembl:ENSP00000407083|ensembl:ENSP00000408683|ensembl:ENSP00000502997|ensembl:ENSP00000503136|ensembl:ENSP00000503525|uniprotkb:D3DPC5|uniprotkb:D3DPC6 intact:EBI-25475797 psi-mi:ppig_human(display_long)|uniprotkb:PPIG(gene name)|psi-mi:PPIG(display_short)|uniprotkb:Cyclophilin G(gene name synonym)|uniprotkb:Clk-associating RS-cyclophilin(gene name synonym)|uniprotkb:CASP10(gene name synonym)|uniprotkb:Rotamase G(gene name synonym) psi-mi:p0c6x7-pro_0000037309(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25488239|imex:IM-27830-13 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004783.2|ensembl:ENSG00000138398(gene)|ensembl:ENST00000260970(transcript)|ensembl:ENST00000433207(transcript)|ensembl:ENST00000448752(transcript)|ensembl:ENST00000676756(transcript)|ensembl:ENST00000678499(transcript)|ensembl:ENST00000679107(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003723"(RNA binding)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008380"(RNA splicing)|go:"GO:0016018"(cyclosporin A binding)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR002130(Peptidyl-prolyl cis-trans isomerase, cyclophilin-type)|interpro:IPR020892|interpro:IPR029000|mint:Q13427|rcsb pdb:2GW2|rcsb pdb:2WFI|rcsb pdb:2WFJ|rcsb pdb:5YZG|go:"GO:0006457"(protein folding)|refseq:XP_005247023.1|refseq:XP_005247024.1 intact:EBI-7843867(chain-parent)|uniprotkb:P0C6X7(chain-parent) - - chain-seq-start:1|chain-seq-end:180 figure legend:F3A|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2020/03/19 2020/03/25 rogid:gp1Pqv5G8E+PrPmp+BtUSSIkD/89606 rogid:qbwEpGmE3J035KnL6QbEZ/HRJAw694009 rigid:sqdrig/dgD9sPMytUqoSAGDUpY8 false renilla luciferase protein tag:n-n protein a tag:n-n|necessary binding region:1-93 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P62942 uniprotkb:P0C6X7-PRO_0000037309 intact:EBI-1027571|uniprotkb:P20071|uniprotkb:Q4VC47|uniprotkb:Q6FGD9|uniprotkb:Q6LEU3|uniprotkb:Q9H103|uniprotkb:Q9H566|uniprotkb:D3DVW6|ensembl:ENSP00000371138|ensembl:ENSP00000371143|ensembl:ENSP00000383003|ensembl:ENSP00000503033|ensembl:ENSP00000503152 intact:EBI-25475797 psi-mi:fkb1a_human(display_long)|uniprotkb:FKBP1A(gene name)|psi-mi:FKBP1A(display_short)|uniprotkb:FKBP1(gene name synonym)|uniprotkb:FKBP12(gene name synonym)|uniprotkb:FK506-binding protein 1A(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:Immunophilin FKBP12(gene name synonym)|uniprotkb:12 kDa FK506-binding protein(gene name synonym)|uniprotkb:Calstabin-1(gene name synonym) psi-mi:p0c6x7-pro_0000037309(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25488249|imex:IM-27830-15 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000088832(gene)|ensembl:ENST00000381719(transcript)|ensembl:ENST00000381724(transcript)|ensembl:ENST00000400137(transcript)|ensembl:ENST00000677335(transcript)|ensembl:ENST00000678408(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005527"(macrolide binding)|go:"GO:0005528"(FK506 binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006458"('de novo' protein folding)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0014802"(terminal cisterna)|go:"GO:0016020"(membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0030018"(Z disc)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031312"(extrinsic component of organelle membrane)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032925"(regulation of activin receptor signaling pathway)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0042026"(protein refolding)|go:"GO:0042110"(T cell activation)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0046332"(SMAD binding)|go:"GO:0048185"(activin binding)|go:"GO:0050776"(regulation of immune response)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0060347"(heart trabecula formation)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0098562"(cytoplasmic side of membrane)|go:"GO:1902991"(regulation of amyloid precursor protein catabolic process)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990425"(ryanodine receptor complex)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|rcsb pdb:1A7X|rcsb pdb:1B6C|rcsb pdb:1BKF|rcsb pdb:1BL4|rcsb pdb:1D6O|rcsb pdb:1D7H|rcsb pdb:1D7I|rcsb pdb:1D7J|rcsb pdb:1EYM|rcsb pdb:1F40|rcsb pdb:1FAP|rcsb pdb:1FKB|rcsb pdb:1FKD|rcsb pdb:1FKF|rcsb pdb:1FKG|rcsb pdb:1FKH|rcsb pdb:1FKI|rcsb pdb:2DG4|rcsb pdb:2DG9|rcsb pdb:2FAP|rcsb pdb:2FKE|rcsb pdb:2ND5|rcsb pdb:2PPN|rcsb pdb:2PPO|rcsb pdb:2PPP|rcsb pdb:2RSE|rcsb pdb:3FAP|rcsb pdb:1FKJ|rcsb pdb:3H9R|rcsb pdb:3MDY|rcsb pdb:4DH0|rcsb pdb:4FAP|rcsb pdb:1FKR|rcsb pdb:4IPX|rcsb pdb:4N19|rcsb pdb:4ODP|rcsb pdb:4ODQ|rcsb pdb:4ODR|rcsb pdb:5I7P|rcsb pdb:5I7Q|rcsb pdb:6I1S|rcsb pdb:1FKS|rcsb pdb:6M4U|rcsb pdb:6OQA|rcsb pdb:6VCU|rcsb pdb:6YF0|rcsb pdb:6YF1|rcsb pdb:6YF2|rcsb pdb:6YF3|reactome:R-HSA-166208|rcsb pdb:1FKT|reactome:R-HSA-2025928|reactome:R-HSA-2173789|reactome:R-HSA-2173791|reactome:R-HSA-3656535|rcsb pdb:1J4H|rcsb pdb:1J4I|reactome:R-HSA-9679191|rcsb pdb:1J4R|rcsb pdb:1NSG|rcsb pdb:1QPF|rcsb pdb:1QPL|rcsb pdb:2DG3|refseq:NP_000792.1|refseq:NP_463460.1|dip:DIP-29710N intact:EBI-7843867(chain-parent)|uniprotkb:P0C6X7(chain-parent) - - chain-seq-start:1|chain-seq-end:180 figure legend:F3A|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2020/03/19 2020/03/27 rogid:3eikHNIIVs8AFM7PYVWurI/9KUY9606 rogid:qbwEpGmE3J035KnL6QbEZ/HRJAw694009 rigid:12k3v6POf9dqKbeZN+eWt1BHJNc false renilla luciferase protein tag:n-n protein a tag:n-n|necessary binding region:1-93 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O43447 uniprotkb:P0C6X7-PRO_0000037309 intact:EBI-1055615|intact:EBI-6190037|uniprotkb:A6NNE7|ensembl:ENSP00000503384|ensembl:ENSP00000503489|ensembl:ENSP00000503922|ensembl:ENSP00000504108|ensembl:ENSP00000504595|ensembl:ENSP00000361630|ensembl:ENSP00000306614 intact:EBI-25475797 psi-mi:ppih_human(display_long)|uniprotkb:U-snRNP-associated cyclophilin SnuCyp-20(gene name synonym)|uniprotkb:Small nuclear ribonucleoprotein particle-specific cyclophilin H(gene name synonym)|uniprotkb:PPIH(gene name)|psi-mi:PPIH(display_short)|uniprotkb:CYP20(gene name synonym)|uniprotkb:CYPH(gene name synonym)|uniprotkb:Rotamase H(gene name synonym) psi-mi:p0c6x7-pro_0000037309(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25488262|imex:IM-27830-17 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006338.1|refseq:XP_005270419.1|ensembl:ENST00000304979(transcript)|ensembl:ENST00000372550(transcript)|ensembl:ENST00000676675(transcript)|ensembl:ENST00000677900(transcript)|ensembl:ENST00000678038(transcript)|ensembl:ENST00000678333(transcript)|ensembl:ENST00000678803(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006457"(protein folding)|go:"GO:0016018"(cyclosporin A binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071001"(U4/U6 snRNP)|interpro:IPR002130(Peptidyl-prolyl cis-trans isomerase, cyclophilin-type)|interpro:IPR020892|interpro:IPR024936|interpro:IPR029000|mint:O43447|rcsb pdb:1MZW|rcsb pdb:1QOI|rcsb pdb:5O9Z|rcsb pdb:6AHD|reactome:R-HSA-72163|ensembl:ENSG00000171960(gene)|refseq:NP_001317439.1|refseq:XP_016855546.1|refseq:XP_016855547.1|refseq:XP_016855548.1 intact:EBI-7843867(chain-parent)|uniprotkb:P0C6X7(chain-parent) - - chain-seq-start:1|chain-seq-end:180 figure legend:F3A|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2020/03/19 2020/03/25 rogid:6gE98w/LLmT7FlCBnaBDk+GWvQU9606 rogid:qbwEpGmE3J035KnL6QbEZ/HRJAw694009 rigid:qq/wuv0iWQs0JoZye2WztzC4oPo false renilla luciferase protein tag:n-n protein a tag:n-n|necessary binding region:1-93 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P0C6X7-PRO_0000037309 uniprotkb:O43447 intact:EBI-25475797 intact:EBI-1055615|intact:EBI-6190037|uniprotkb:A6NNE7|ensembl:ENSP00000503384|ensembl:ENSP00000503489|ensembl:ENSP00000503922|ensembl:ENSP00000504108|ensembl:ENSP00000504595|ensembl:ENSP00000361630|ensembl:ENSP00000306614 psi-mi:p0c6x7-pro_0000037309(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:ppih_human(display_long)|uniprotkb:U-snRNP-associated cyclophilin SnuCyp-20(gene name synonym)|uniprotkb:Small nuclear ribonucleoprotein particle-specific cyclophilin H(gene name synonym)|uniprotkb:PPIH(gene name)|psi-mi:PPIH(display_short)|uniprotkb:CYP20(gene name synonym)|uniprotkb:CYPH(gene name synonym)|uniprotkb:Rotamase H(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25489221|imex:IM-27830-190 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7843867(chain-parent)|uniprotkb:P0C6X7(chain-parent) refseq:NP_006338.1|refseq:XP_005270419.1|ensembl:ENST00000304979(transcript)|ensembl:ENST00000372550(transcript)|ensembl:ENST00000676675(transcript)|ensembl:ENST00000677900(transcript)|ensembl:ENST00000678038(transcript)|ensembl:ENST00000678333(transcript)|ensembl:ENST00000678803(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006457"(protein folding)|go:"GO:0016018"(cyclosporin A binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071001"(U4/U6 snRNP)|interpro:IPR002130(Peptidyl-prolyl cis-trans isomerase, cyclophilin-type)|interpro:IPR020892|interpro:IPR024936|interpro:IPR029000|mint:O43447|rcsb pdb:1MZW|rcsb pdb:1QOI|rcsb pdb:5O9Z|rcsb pdb:6AHD|reactome:R-HSA-72163|ensembl:ENSG00000171960(gene)|refseq:NP_001317439.1|refseq:XP_016855546.1|refseq:XP_016855547.1|refseq:XP_016855548.1 - chain-seq-start:1|chain-seq-end:180 - figure legend:ST1|comment:the Z-score of this interaction is 2.7|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2020/03/19 2020/03/30 rogid:qbwEpGmE3J035KnL6QbEZ/HRJAw694009 rogid:6gE98w/LLmT7FlCBnaBDk+GWvQU9606 rigid:qq/wuv0iWQs0JoZye2WztzC4oPo false protein a tag:n-n renilla luciferase protein tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P0C6X7-PRO_0000037309 uniprotkb:Q9UQN3 intact:EBI-25475797 intact:EBI-718324|uniprotkb:Q53HC7|uniprotkb:Q9Y4U6|intact:EBI-11161391|uniprotkb:B4DJG8|ensembl:ENSP00000263780 psi-mi:p0c6x7-pro_0000037309(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:chm2b_human(display_long)|uniprotkb:Chromatin-modifying protein 2b(gene name synonym)|uniprotkb:CHMP2.5(gene name synonym)|uniprotkb:Vacuolar protein sorting-associated protein 2-2(gene name synonym)|uniprotkb:CHMP2B(gene name)|psi-mi:CHMP2B(display_short)|uniprotkb:CGI-84(orf name) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25489254|imex:IM-27830-54 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7843867(chain-parent)|uniprotkb:P0C6X7(chain-parent) refseq:NP_054762.2|refseq:NP_001231573.1|ensembl:ENSG00000083937(gene)|ensembl:ENST00000263780(transcript)|go:"GO:0000815"(ESCRT III complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005771"(multivesicular body)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0006997"(nucleus organization)|go:"GO:0007032"(endosome organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016236"(macroautophagy)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032509"(endosome transport via multivesicular body sorting pathway)|go:"GO:0036258"(multivesicular body assembly)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0045296"(cadherin binding)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0050890"(cognition)|go:"GO:0061763"(multivesicular body-lysosome fusion)|go:"GO:0061952"(midbody abscission)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099159"(regulation of modification of postsynaptic structure)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:1901673"(regulation of mitotic spindle assembly)|go:"GO:1902188"(obsolete positive regulation of viral release from host cell)|go:"GO:1904903"(ESCRT III complex disassembly)|interpro:IPR005024(Snf7)|mint:Q9UQN3|rcsb pdb:2JQK|reactome:R-HSA-162588|reactome:R-HSA-1632852|reactome:R-HSA-5620971|reactome:R-HSA-917729|reactome:R-HSA-9610379|reactome:R-HSA-9615710|reactome:R-HSA-9668328|reactome:R-HSA-9679504|reactome:R-HSA-9694676|go:"GO:0010824"(regulation of centrosome duplication)|dip:DIP-50766N - chain-seq-start:1|chain-seq-end:180 - figure legend:ST1|comment:the Z-score of this interaction is 1.3|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2020/03/19 2020/03/30 rogid:qbwEpGmE3J035KnL6QbEZ/HRJAw694009 rogid:WmtZzxKkbkLsgFov/DJDKKGvIto9606 rigid:CR1K2vGrwYOoh3MmO4hyX6M9yCs false protein a tag:n-n renilla luciferase protein tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P0C6X7-PRO_0000037309 uniprotkb:P62942 intact:EBI-25475797 intact:EBI-1027571|uniprotkb:P20071|uniprotkb:Q4VC47|uniprotkb:Q6FGD9|uniprotkb:Q6LEU3|uniprotkb:Q9H103|uniprotkb:Q9H566|uniprotkb:D3DVW6|ensembl:ENSP00000371138|ensembl:ENSP00000371143|ensembl:ENSP00000383003|ensembl:ENSP00000503033|ensembl:ENSP00000503152 psi-mi:p0c6x7-pro_0000037309(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:fkb1a_human(display_long)|uniprotkb:FKBP1A(gene name)|psi-mi:FKBP1A(display_short)|uniprotkb:FKBP1(gene name synonym)|uniprotkb:FKBP12(gene name synonym)|uniprotkb:FK506-binding protein 1A(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:Immunophilin FKBP12(gene name synonym)|uniprotkb:12 kDa FK506-binding protein(gene name synonym)|uniprotkb:Calstabin-1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25489199|imex:IM-27830-148 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7843867(chain-parent)|uniprotkb:P0C6X7(chain-parent) ensembl:ENSG00000088832(gene)|ensembl:ENST00000381719(transcript)|ensembl:ENST00000381724(transcript)|ensembl:ENST00000400137(transcript)|ensembl:ENST00000677335(transcript)|ensembl:ENST00000678408(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005527"(macrolide binding)|go:"GO:0005528"(FK506 binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006458"('de novo' protein folding)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0014802"(terminal cisterna)|go:"GO:0016020"(membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0030018"(Z disc)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031312"(extrinsic component of organelle membrane)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032925"(regulation of activin receptor signaling pathway)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0042026"(protein refolding)|go:"GO:0042110"(T cell activation)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0046332"(SMAD binding)|go:"GO:0048185"(activin binding)|go:"GO:0050776"(regulation of immune response)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0060347"(heart trabecula formation)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0098562"(cytoplasmic side of membrane)|go:"GO:1902991"(regulation of amyloid precursor protein catabolic process)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990425"(ryanodine receptor complex)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|rcsb pdb:1A7X|rcsb pdb:1B6C|rcsb pdb:1BKF|rcsb pdb:1BL4|rcsb pdb:1D6O|rcsb pdb:1D7H|rcsb pdb:1D7I|rcsb pdb:1D7J|rcsb pdb:1EYM|rcsb pdb:1F40|rcsb pdb:1FAP|rcsb pdb:1FKB|rcsb pdb:1FKD|rcsb pdb:1FKF|rcsb pdb:1FKG|rcsb pdb:1FKH|rcsb pdb:1FKI|rcsb pdb:2DG4|rcsb pdb:2DG9|rcsb pdb:2FAP|rcsb pdb:2FKE|rcsb pdb:2ND5|rcsb pdb:2PPN|rcsb pdb:2PPO|rcsb pdb:2PPP|rcsb pdb:2RSE|rcsb pdb:3FAP|rcsb pdb:1FKJ|rcsb pdb:3H9R|rcsb pdb:3MDY|rcsb pdb:4DH0|rcsb pdb:4FAP|rcsb pdb:1FKR|rcsb pdb:4IPX|rcsb pdb:4N19|rcsb pdb:4ODP|rcsb pdb:4ODQ|rcsb pdb:4ODR|rcsb pdb:5I7P|rcsb pdb:5I7Q|rcsb pdb:6I1S|rcsb pdb:1FKS|rcsb pdb:6M4U|rcsb pdb:6OQA|rcsb pdb:6VCU|rcsb pdb:6YF0|rcsb pdb:6YF1|rcsb pdb:6YF2|rcsb pdb:6YF3|reactome:R-HSA-166208|rcsb pdb:1FKT|reactome:R-HSA-2025928|reactome:R-HSA-2173789|reactome:R-HSA-2173791|reactome:R-HSA-3656535|rcsb pdb:1J4H|rcsb pdb:1J4I|reactome:R-HSA-9679191|rcsb pdb:1J4R|rcsb pdb:1NSG|rcsb pdb:1QPF|rcsb pdb:1QPL|rcsb pdb:2DG3|refseq:NP_000792.1|refseq:NP_463460.1|dip:DIP-29710N - chain-seq-start:1|chain-seq-end:180 - figure legend:ST1|comment:the Z-score of this interaction is 2.9|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2020/03/19 2020/03/30 rogid:qbwEpGmE3J035KnL6QbEZ/HRJAw694009 rogid:3eikHNIIVs8AFM7PYVWurI/9KUY9606 rigid:12k3v6POf9dqKbeZN+eWt1BHJNc false protein a tag:n-n renilla luciferase protein tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P0C6X7-PRO_0000037309 uniprotkb:Q9Y4W2 intact:EBI-25475797 intact:EBI-1051591|uniprotkb:Q5JXQ0|uniprotkb:Q8TEN5|uniprotkb:Q9H9V5|uniprotkb:A9X410|ensembl:ENSP00000363944 psi-mi:p0c6x7-pro_0000037309(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:las1l_human(display_long)|uniprotkb:LAS1L(gene name)|psi-mi:LAS1L(display_short)|uniprotkb:Protein LAS1 homolog(gene name synonym)|uniprotkb:MSTP060(orf name) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25489243|imex:IM-27830-206 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7843867(chain-parent)|uniprotkb:P0C6X7(chain-parent) refseq:NP_001164120.1|refseq:NP_001164121.1|refseq:NP_112483.1|ensembl:ENSG00000001497(gene)|ensembl:ENST00000374811(transcript)|go:"GO:0000460"(maturation of 5.8S rRNA)|go:"GO:0000470"(maturation of LSU-rRNA)|go:"GO:0003723"(RNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0016020"(membrane)|go:"GO:0030687"(preribosome, large subunit precursor)|go:"GO:0071339"(MLL1 complex)|go:"GO:0090730"(Las1 complex)|interpro:IPR007174(Las1-like)|mint:Q9Y4W2|reactome:R-HSA-6791226 - chain-seq-start:1|chain-seq-end:180 - figure legend:ST1|comment:the Z-score of this interaction is 1.4|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2020/03/19 2020/03/30 rogid:qbwEpGmE3J035KnL6QbEZ/HRJAw694009 rogid:1TTE2TCMIwczNaT2SSMLioLkALA9606 rigid:0vkXITeZydQGYNw6u3zwpxOWsPY false protein a tag:n-n renilla luciferase protein tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P0C6X7-PRO_0000037309 uniprotkb:Q5SQN1 intact:EBI-25475797 intact:EBI-10244848|uniprotkb:Q8TB31|uniprotkb:Q9BT10|uniprotkb:Q5TBZ3|uniprotkb:Q96FE1|uniprotkb:Q8N558|uniprotkb:Q8WV46|uniprotkb:Q96CQ3|uniprotkb:Q8TCW8|uniprotkb:Q96NU3|uniprotkb:Q5HYB5|uniprotkb:Q96I66|uniprotkb:Q9BVB2|uniprotkb:B6EDE0 psi-mi:p0c6x7-pro_0000037309(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:snp47_human(display_long)|uniprotkb:SNAP47(gene name)|psi-mi:SNAP47(display_short)|uniprotkb:C1orf142(gene name synonym)|uniprotkb:Epididymis luminal protein 170(gene name synonym)|uniprotkb:HEL170(gene name synonym)|uniprotkb:SVAP1(gene name synonym)|uniprotkb:Synaptosomal-associated 47 kDa protein(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25489265|imex:IM-27830-132 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7843867(chain-parent)|uniprotkb:P0C6X7(chain-parent) interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR000727(Target SNARE coiled-coil region)|refseq:NP_444280.2|refseq:NP_001310864.1|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0012505"(endomembrane system)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0019905"(syntaxin binding)|go:"GO:0031201"(SNARE complex)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0098793"(presynapse)|refseq:XP_016855720.1|refseq:XP_016855721.1 - chain-seq-start:1|chain-seq-end:180 - figure legend:ST1|comment:the Z-score of this interaction is 1.3|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2020/03/19 2020/03/30 rogid:qbwEpGmE3J035KnL6QbEZ/HRJAw694009 rogid:hKGKMfU5GPf/qU+vuwByphqX3NA9606 rigid:JhkV7WEzEwre8wabeOOrWzcNk/I false protein a tag:n-n renilla luciferase protein tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P0C6X7-PRO_0000037309 uniprotkb:Q9UKA8 intact:EBI-25475797 intact:EBI-9091952|uniprotkb:A4GU14|uniprotkb:Q9UKA7|uniprotkb:E7ENV1|uniprotkb:Q5ECL3|uniprotkb:A4LA69|uniprotkb:Q5TGC6|uniprotkb:E7EWD8|uniprotkb:Q9NUC8|uniprotkb:E3VWE2|uniprotkb:E5L4P0|uniprotkb:E5L4P7|uniprotkb:G1FI66|uniprotkb:G1FLF0|ensembl:ENSP00000363516|ensembl:ENSP00000445401 psi-mi:p0c6x7-pro_0000037309(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:rcan3_human(display_long)|uniprotkb:DSCR1L2(gene name synonym)|uniprotkb:Down syndrome candidate region 1-like protein 2(gene name synonym)|uniprotkb:Myocyte-enriched calcineurin-interacting protein 3(gene name synonym)|uniprotkb:Regulator of calcineurin 3(gene name synonym)|uniprotkb:RCAN3(gene name)|psi-mi:RCAN3(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25489232|imex:IM-27830-204 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7843867(chain-parent)|uniprotkb:P0C6X7(chain-parent) refseq:NP_001238911.1|refseq:NP_001238912.1|refseq:NP_001238914.1|refseq:NP_038469.1|refseq:NP_001238906.1|refseq:NP_001238907.1|refseq:NP_001238908.1|refseq:NP_001238909.1|refseq:NP_001238910.1|refseq:NP_001238913.1|ensembl:ENSG00000117602(gene)|ensembl:ENST00000374395(transcript)|ensembl:ENST00000538532(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008597"(calcium-dependent protein serine/threonine phosphatase regulator activity)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019902"(phosphatase binding)|go:"GO:0031013"(troponin I binding)|interpro:IPR006931(Calcipressin)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034923|interpro:IPR035979 - chain-seq-start:1|chain-seq-end:180 - figure legend:ST1|comment:the Z-score of this interaction is 2.5|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2020/03/19 2020/03/30 rogid:qbwEpGmE3J035KnL6QbEZ/HRJAw694009 rogid:GcjmPxKst3ISAOr1WMhJLrYq8JY9606 rigid:yBJ2AnAxgG3aUtRij6HmOwenhHI false protein a tag:n-n renilla luciferase protein tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P0C6X7-PRO_0000037309 uniprotkb:Q13427 intact:EBI-25475797 intact:EBI-396072|uniprotkb:O00706|uniprotkb:Q96DG9|uniprotkb:Q53R40|uniprotkb:Q53SN4|ensembl:ENSP00000260970|ensembl:ENSP00000407083|ensembl:ENSP00000408683|ensembl:ENSP00000502997|ensembl:ENSP00000503136|ensembl:ENSP00000503525|uniprotkb:D3DPC5|uniprotkb:D3DPC6 psi-mi:p0c6x7-pro_0000037309(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:ppig_human(display_long)|uniprotkb:PPIG(gene name)|psi-mi:PPIG(display_short)|uniprotkb:Cyclophilin G(gene name synonym)|uniprotkb:Clk-associating RS-cyclophilin(gene name synonym)|uniprotkb:CASP10(gene name synonym)|uniprotkb:Rotamase G(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25489210|imex:IM-27830-52 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7843867(chain-parent)|uniprotkb:P0C6X7(chain-parent) refseq:NP_004783.2|ensembl:ENSG00000138398(gene)|ensembl:ENST00000260970(transcript)|ensembl:ENST00000433207(transcript)|ensembl:ENST00000448752(transcript)|ensembl:ENST00000676756(transcript)|ensembl:ENST00000678499(transcript)|ensembl:ENST00000679107(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003723"(RNA binding)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008380"(RNA splicing)|go:"GO:0016018"(cyclosporin A binding)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR002130(Peptidyl-prolyl cis-trans isomerase, cyclophilin-type)|interpro:IPR020892|interpro:IPR029000|mint:Q13427|rcsb pdb:2GW2|rcsb pdb:2WFI|rcsb pdb:2WFJ|rcsb pdb:5YZG|go:"GO:0006457"(protein folding)|refseq:XP_005247023.1|refseq:XP_005247024.1 - chain-seq-start:1|chain-seq-end:180 - figure legend:ST1|comment:the Z-score of this interaction is 2.8|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2020/03/19 2020/03/30 rogid:qbwEpGmE3J035KnL6QbEZ/HRJAw694009 rogid:gp1Pqv5G8E+PrPmp+BtUSSIkD/89606 rigid:sqdrig/dgD9sPMytUqoSAGDUpY8 false protein a tag:n-n renilla luciferase protein tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P0C6X7-PRO_0000037309 uniprotkb:P62937 intact:EBI-25475797 intact:EBI-437708|uniprotkb:P05092|uniprotkb:Q3KQW3|uniprotkb:Q6IBU5|uniprotkb:Q96IX3|uniprotkb:Q9BRU4|uniprotkb:Q9BTY9|uniprotkb:Q9UC61|uniprotkb:Q567Q0|ensembl:ENSP00000419425|uniprotkb:A8K220 psi-mi:p0c6x7-pro_0000037309(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:ppia_human(display_long)|uniprotkb:Cyclophilin A(gene name synonym)|uniprotkb:Cyclosporin A-binding protein(gene name synonym)|uniprotkb:PPIA(gene name)|psi-mi:PPIA(display_short)|uniprotkb:CYPA(gene name synonym)|uniprotkb:Rotamase A(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25489188|imex:IM-27830-130 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7843867(chain-parent)|uniprotkb:P0C6X7(chain-parent) refseq:NP_066953.1|interpro:IPR029000|mint:P62937|rcsb pdb:1AK4|rcsb pdb:1AWQ|rcsb pdb:1AWR|rcsb pdb:1AWS|rcsb pdb:1AWT|rcsb pdb:1AWU|rcsb pdb:1AWV|rcsb pdb:1BCK|rcsb pdb:1CWA|rcsb pdb:1CWB|rcsb pdb:1CWC|rcsb pdb:1CWF|rcsb pdb:1CWH|rcsb pdb:1CWI|rcsb pdb:1CWJ|rcsb pdb:1CWK|rcsb pdb:1CWL|rcsb pdb:1CWM|interpro:IPR024936|rcsb pdb:1CWO|rcsb pdb:1FGL|rcsb pdb:2N0T|rcsb pdb:2RMA|rcsb pdb:1M63|rcsb pdb:2RMB|rcsb pdb:2X25|rcsb pdb:2X2A|rcsb pdb:2X2C|rcsb pdb:2X2D|rcsb pdb:1M9C|rcsb pdb:1M9D|rcsb pdb:1M9E|rcsb pdb:2XGY|rcsb pdb:3CYH|rcsb pdb:3CYS|rcsb pdb:3K0M|rcsb pdb:3K0N|rcsb pdb:3K0O|rcsb pdb:3K0P|rcsb pdb:3K0Q|rcsb pdb:3K0R|rcsb pdb:3ODI|rcsb pdb:3ODL|rcsb pdb:1M9F|rcsb pdb:3RDD|rcsb pdb:1M9X|rcsb pdb:1M9Y|rcsb pdb:4CYH|rcsb pdb:4IPZ|rcsb pdb:4N1M|rcsb pdb:4N1N|rcsb pdb:1MF8|rcsb pdb:4N1O|rcsb pdb:4N1P|rcsb pdb:4N1Q|rcsb pdb:1MIK|rcsb pdb:1NMK|rcsb pdb:1OCA|rcsb pdb:1RMH|rcsb pdb:1VBS|rcsb pdb:1VBT|rcsb pdb:1W8L|rcsb pdb:1W8M|rcsb pdb:1W8V|rcsb pdb:1YND|rcsb pdb:1ZKF|rcsb pdb:2ALF|rcsb pdb:2CPL|rcsb pdb:2CYH|rcsb pdb:2MS4|rcsb pdb:2MZU|rcsb pdb:4N1R|rcsb pdb:4N1S|rcsb pdb:4YUG|rcsb pdb:4YUH|refseq:NP_001287910.1|reactome:R-HSA-210991|reactome:R-HSA-6798695|reactome:R-HSA-8950505|reactome:R-HSA-2025928|ensembl:ENSG00000196262(gene)|ensembl:ENST00000468812(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006457"(protein folding)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006915"(apoptotic process)|go:"GO:0016018"(cyclosporin A binding)|go:"GO:0016020"(membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0030168"(platelet activation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031982"(vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032873"(negative regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034389"(lipid droplet organization)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045069"(regulation of viral genome replication)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046790"(virion binding)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060352"(cell adhesion molecule production)|go:"GO:0061944"(negative regulation of protein K48-linked ubiquitination)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903901"(negative regulation of viral life cycle)|go:"GO:1904399"(heparan sulfate binding)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2001233"(regulation of apoptotic signaling pathway)|interpro:IPR002130(Peptidyl-prolyl cis-trans isomerase, cyclophilin-type)|interpro:IPR020892|go:"GO:0005178"(integrin binding)|rcsb pdb:4YUI|rcsb pdb:4YUJ|rcsb pdb:4YUK|rcsb pdb:4YUL|rcsb pdb:4YUM|rcsb pdb:4YUN|rcsb pdb:4YUO|rcsb pdb:4YUP|rcsb pdb:5CYH|rcsb pdb:5F66|rcsb pdb:5FJB|rcsb pdb:5KUL|rcsb pdb:5KUN|rcsb pdb:5KUO|rcsb pdb:5KUQ|rcsb pdb:5KUR|rcsb pdb:5KUS|rcsb pdb:5KUU|rcsb pdb:5KUV|rcsb pdb:5KUW|rcsb pdb:5KUZ|rcsb pdb:5KV0|rcsb pdb:5KV1|rcsb pdb:5KV2|rcsb pdb:5KV3|rcsb pdb:5KV4|rcsb pdb:5KV5|rcsb pdb:5KV6|rcsb pdb:5KV7|rcsb pdb:5LUD|rcsb pdb:5NOQ|rcsb pdb:5NOR|rcsb pdb:5NOT|rcsb pdb:5NOU|rcsb pdb:5NOV|rcsb pdb:5NOW|rcsb pdb:5NOX|rcsb pdb:5NOY|rcsb pdb:5NOZ|rcsb pdb:5T9U|rcsb pdb:5T9W|rcsb pdb:5T9Z|rcsb pdb:5TA2|rcsb pdb:5TA4|rcsb pdb:5WC7|rcsb pdb:6BTA|rcsb pdb:6GJI|rcsb pdb:6GJJ|rcsb pdb:6GJL|rcsb pdb:6GJM|rcsb pdb:6GJN|rcsb pdb:6GJP|rcsb pdb:6GJR|rcsb pdb:6GJY|rcsb pdb:6GS6|rcsb pdb:6I42|rcsb pdb:6U5C|rcsb pdb:6U5D|rcsb pdb:6U5E|rcsb pdb:6U5G|rcsb pdb:6X3R|rcsb pdb:6X3Y|rcsb pdb:5NOS|rcsb pdb:6X4N|rcsb pdb:6X4O|rcsb pdb:6X4P|rcsb pdb:6X4Q|rcsb pdb:6Y9V|rcsb pdb:6Y9W|rcsb pdb:6Y9X|rcsb pdb:6Y9Y|rcsb pdb:6Y9Z|rcsb pdb:6ZDJ|rcsb pdb:7ABT|reactome:R-HSA-114608|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-173107|rcsb pdb:6X4M|reactome:R-HSA-175474|reactome:R-HSA-180689|dip:DIP-6080N - chain-seq-start:1|chain-seq-end:180 - figure legend:ST1|comment:the Z-score of this interaction is 3.2|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2020/03/19 2020/03/30 rogid:qbwEpGmE3J035KnL6QbEZ/HRJAw694009 rogid:dr4EVxcO+sqTPBqsQcydRn+rHoo9606 rigid:XX/pCBj3HQy8hQeRejP0dbpwzRQ false protein a tag:n-n renilla luciferase protein tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P0C6X7-PRO_0000037309 uniprotkb:Q99471 intact:EBI-25475797 intact:EBI-357275|ensembl:ENSP00000334188|ensembl:ENSP00000447942|intact:EBI-1047551|uniprotkb:A8K9A8|uniprotkb:Q54AA8|uniprotkb:Q9C083|uniprotkb:Q9C084 psi-mi:p0c6x7-pro_0000037309(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:pfd5_human(display_long)|uniprotkb:c-Myc-binding protein Mm-1(gene name synonym)|uniprotkb:PFDN5(gene name)|psi-mi:PFDN5(display_short)|uniprotkb:MM1(gene name synonym)|uniprotkb:Myc modulator 1(gene name synonym)|uniprotkb:PFD5(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25489298|imex:IM-27830-150 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7843867(chain-parent)|uniprotkb:P0C6X7(chain-parent) ensembl:ENSG00000123349(gene)|ensembl:ENST00000334478(transcript)|ensembl:ENST00000551018(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006457"(protein folding)|go:"GO:0016272"(prefoldin complex)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|interpro:IPR004127(Prefoldin alpha-like)|interpro:IPR009053(Prefoldin)|interpro:IPR011599(Prefoldin alpha subunit)|mint:Q99471|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|reactome:R-HSA-389957|refseq:NP_002615.2|refseq:NP_665904.1|dip:DIP-28155N - chain-seq-start:1|chain-seq-end:180 - figure legend:ST1|comment:the Z-score of this interaction is 2|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2020/03/19 2020/03/30 rogid:qbwEpGmE3J035KnL6QbEZ/HRJAw694009 rogid:Cm4km207qcfDJYRUCIwUxMBT4tE9606 rigid:8n7WM2cQzC9z03wb9RlYOV2HWd0 false protein a tag:n-n renilla luciferase protein tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P0C6X7-PRO_0000037310 uniprotkb:P05155 intact:EBI-25474098 intact:EBI-1223454|uniprotkb:Q547W3|uniprotkb:Q59EI5|uniprotkb:Q96FE0|uniprotkb:A6NMU0|uniprotkb:A8KAI9|uniprotkb:B2R6L5|uniprotkb:Q16304|uniprotkb:Q7Z455|uniprotkb:Q9UC49|uniprotkb:Q9UCF9|uniprotkb:B4E1F0|uniprotkb:B4E1H2|ensembl:ENSP00000278407|ensembl:ENSP00000504807 psi-mi:p0c6x7-pro_0000037310(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:ic1_human(display_long)|uniprotkb:SERPING1(gene name)|psi-mi:SERPING1(display_short)|uniprotkb:C1IN(gene name synonym)|uniprotkb:C1NH(gene name synonym)|uniprotkb:C1 esterase inhibitor(gene name synonym)|uniprotkb:C1-inhibiting factor(gene name synonym)|uniprotkb:Serpin G1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25489342|imex:IM-27830-194 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7843867(chain-parent)|uniprotkb:P0C6X7(chain-parent) refseq:NP_000053.2|refseq:NP_001027466.1|dip:DIP-45635N|ensembl:ENSG00000149131(gene)|ensembl:ENST00000278407(transcript)|ensembl:ENST00000676670(transcript)|go:"GO:0001869"(negative regulation of complement activation, lectin pathway)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0007568"(aging)|go:"GO:0007596"(blood coagulation)|go:"GO:0008015"(blood circulation)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0042730"(fibrinolysis)|go:"GO:0045087"(innate immune response)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR015553(Protease inhibitor I4, serpin C1)|interpro:IPR023795|interpro:IPR023796|interpro:IPR036186|interpro:IPR042178|interpro:IPR042185|mint:P05155|rcsb pdb:1M6Q|rcsb pdb:2OAY|rcsb pdb:5DU3|rcsb pdb:5DUQ|rcsb pdb:7AKV|reactome:R-HSA-114608|reactome:R-HSA-140837|reactome:R-HSA-9657689|reactome:R-HSA-977606 - chain-seq-start:181|chain-seq-end:818 - figure legend:ST1|comment:the Z-score of this interaction is 1.5|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2020/03/19 2020/03/30 rogid:uSbjRz4rkYk4xCxFNKoeNwrWAcQ694009 rogid:Y7cqCZ6Ryz51dsi6jM86EXdfeWc9606 rigid:M4R1mQKE2oCszukofYHiIj28ys4 false protein a tag:n-n renilla luciferase protein tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P0C6X7-PRO_0000037319 uniprotkb:O96017 intact:EBI-25487926 intact:EBI-1180783|uniprotkb:Q6QA03|uniprotkb:Q6QA04|uniprotkb:Q6QA05|uniprotkb:Q6QA06|uniprotkb:Q6QA07|uniprotkb:Q6QA08|uniprotkb:Q6QA10|uniprotkb:Q6QA11|uniprotkb:Q6QA12|uniprotkb:Q6QA13|uniprotkb:Q9HCQ8|uniprotkb:Q9UGF0|uniprotkb:Q9UGF1|uniprotkb:B7ZBF3|uniprotkb:B7ZBF4|uniprotkb:B7ZBF5|uniprotkb:Q9HBS5|uniprotkb:A8K3Y9|ensembl:ENSP00000385747|ensembl:ENSP00000386087|ensembl:ENSP00000497000 psi-mi:p0c6x7-pro_0000037319(display_long)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)|uniprotkb:rep(gene name)|psi-mi:rep(display_short) psi-mi:chk2_human(display_long)|uniprotkb:CHEK2(gene name)|psi-mi:CHEK2(display_short)|uniprotkb:CHK2(gene name synonym)|uniprotkb:RAD53(gene name synonym)|uniprotkb:Cds1 homolog(gene name synonym)|uniprotkb:Checkpoint kinase 2(gene name synonym)|uniprotkb:CDS1(gene name synonym)|uniprotkb:CHK2 checkpoint homolog(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25489320|imex:IM-27830-250 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:P0C6X7(chain-parent)|intact:EBI-7843867(chain-parent) refseq:XP_016884050.1|refseq:NP_001005735.1|refseq:NP_009125.1|refseq:NP_665861.1|refseq:NP_001244316.1|refseq:XP_011528147.1|dip:DIP-24270N|ensembl:ENSG00000183765(gene)|ensembl:ENST00000404276(transcript)|ensembl:ENST00000405598(transcript)|ensembl:ENST00000650281(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035690"|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0044773"(mitotic DNA damage checkpoint signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051301"(cell division)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1903416"(response to glycoside)|go:"GO:1903926"(cellular response to bisphenol A)|go:"GO:2000002"(negative regulation of DNA damage checkpoint)|go:"GO:2000210"(positive regulation of anoikis)|interpro:IPR000253(Forkhead-associated)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR011009(Protein kinase-like)|mint:O96017|rcsb pdb:1GXC|rcsb pdb:2CN5|rcsb pdb:2CN8|rcsb pdb:2W0J|go:"GO:0090399"(replicative senescence)|rcsb pdb:2W7X|rcsb pdb:2WTC|rcsb pdb:2WTD|rcsb pdb:2XM8|rcsb pdb:2XM9|rcsb pdb:2YCF|rcsb pdb:2YCQ|rcsb pdb:2YCR|rcsb pdb:2YCS|rcsb pdb:2YIQ|rcsb pdb:2YIR|rcsb pdb:2YIT|rcsb pdb:3I6U|rcsb pdb:3I6W|rcsb pdb:3VA4|rcsb pdb:4A9R|rcsb pdb:4A9S|rcsb pdb:4A9T|rcsb pdb:4A9U|rcsb pdb:4BDA|rcsb pdb:4BDB|rcsb pdb:4BDC|rcsb pdb:4BDD|rcsb pdb:4BDE|rcsb pdb:4BDF|rcsb pdb:4BDG|rcsb pdb:4BDH|rcsb pdb:4BDI|rcsb pdb:4BDJ|rcsb pdb:4BDK|reactome:R-HSA-5693565|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804760|reactome:R-HSA-69473|reactome:R-HSA-69541|reactome:R-HSA-69601|reactome:R-HSA-75035|rcsb pdb:2WTI|rcsb pdb:2WTJ|rcsb pdb:2XBJ|rcsb pdb:2XK9 - chain-seq-start:5302|chain-seq-end:5902 - figure legend:ST1|comment:the Z-score of this interaction is 1.1|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2020/03/19 2020/03/30 rogid:p7KzZyyr+yMS7ZiMTBx4VVZRzGc694009 rogid:LaDEJtqjPoEJZoj1f6vlZiiaZoI9606 rigid:2qQTBq9wfzRz1TekXezJpb3vSSU false protein a tag:n-n renilla luciferase protein tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P0C6X7-PRO_0000037320 uniprotkb:P05155 intact:EBI-25487328 intact:EBI-1223454|uniprotkb:Q547W3|uniprotkb:Q59EI5|uniprotkb:Q96FE0|uniprotkb:A6NMU0|uniprotkb:A8KAI9|uniprotkb:B2R6L5|uniprotkb:Q16304|uniprotkb:Q7Z455|uniprotkb:Q9UC49|uniprotkb:Q9UCF9|uniprotkb:B4E1F0|uniprotkb:B4E1H2|ensembl:ENSP00000278407|ensembl:ENSP00000504807 psi-mi:p0c6x7-pro_0000037320(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:ic1_human(display_long)|uniprotkb:SERPING1(gene name)|psi-mi:SERPING1(display_short)|uniprotkb:C1IN(gene name synonym)|uniprotkb:C1NH(gene name synonym)|uniprotkb:C1 esterase inhibitor(gene name synonym)|uniprotkb:C1-inhibiting factor(gene name synonym)|uniprotkb:Serpin G1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25489331|imex:IM-27830-152 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7843867(chain-parent)|uniprotkb:P0C6X7(chain-parent) refseq:NP_000053.2|refseq:NP_001027466.1|dip:DIP-45635N|ensembl:ENSG00000149131(gene)|ensembl:ENST00000278407(transcript)|ensembl:ENST00000676670(transcript)|go:"GO:0001869"(negative regulation of complement activation, lectin pathway)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0007568"(aging)|go:"GO:0007596"(blood coagulation)|go:"GO:0008015"(blood circulation)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0042730"(fibrinolysis)|go:"GO:0045087"(innate immune response)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR015553(Protease inhibitor I4, serpin C1)|interpro:IPR023795|interpro:IPR023796|interpro:IPR036186|interpro:IPR042178|interpro:IPR042185|mint:P05155|rcsb pdb:1M6Q|rcsb pdb:2OAY|rcsb pdb:5DU3|rcsb pdb:5DUQ|rcsb pdb:7AKV|reactome:R-HSA-114608|reactome:R-HSA-140837|reactome:R-HSA-9657689|reactome:R-HSA-977606 - chain-seq-start:5903|chain-seq-end:6429 - figure legend:ST1|comment:the Z-score of this interaction is 1.1|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2020/03/19 2020/03/30 rogid:FPQjk4Qo6mt2gs5v5hPwe+xPyrI694009 rogid:Y7cqCZ6Ryz51dsi6jM86EXdfeWc9606 rigid:9Adv4BUm55tEsTINX2PO/mIjR7U false protein a tag:n-n renilla luciferase protein tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P0C6X7-PRO_0000037309 uniprotkb:O95299 intact:EBI-25475797 intact:EBI-1246361|uniprotkb:Q8WXC9|ensembl:ENSP00000252711|ensembl:ENSP00000503956|ensembl:ENSP00000504765 psi-mi:p0c6x7-pro_0000037309(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:nduaa_human(display_long)|uniprotkb:NDUFA10(gene name)|psi-mi:NDUFA10(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase 42 kDa subunit(gene name synonym)|uniprotkb:Complex I-42kD(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25489287|imex:IM-27830-72 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7843867(chain-parent)|uniprotkb:P0C6X7(chain-parent) refseq:NP_004535.1|ensembl:ENSG00000130414(gene)|ensembl:ENST00000252711(transcript)|ensembl:ENST00000676929(transcript)|ensembl:ENST00000678158(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR015828(NADH-ubiquinone oxidoreductase, 42 kDa subunit)|interpro:IPR027417|interpro:IPR031314|mint:O95299|rcsb pdb:5XTC|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 - chain-seq-start:1|chain-seq-end:180 - figure legend:ST1|comment:the Z-score of this interaction is 1.7|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2020/03/19 2020/03/30 rogid:qbwEpGmE3J035KnL6QbEZ/HRJAw694009 rogid:8jwJPJ0rD9H7A4AzxPd186tpXYs9606 rigid:4MiOOB5a6zdb1vGpz4NOjTMPQrI false protein a tag:n-n renilla luciferase protein tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P0C6X7-PRO_0000037309 uniprotkb:Q15661 intact:EBI-25475797 intact:EBI-1761369|intact:EBI-1762849|uniprotkb:D2E6R9|uniprotkb:D2E6S1|uniprotkb:P15157|uniprotkb:Q9H2Y5|uniprotkb:Q15663|uniprotkb:Q9H2Y4|uniprotkb:Q9UQI1|uniprotkb:Q6B052|ensembl:ENSP00000343577|ensembl:ENSP00000502948 psi-mi:p0c6x7-pro_0000037309(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:tryb1_human(display_long)|uniprotkb:TPSAB1(gene name)|psi-mi:TPSAB1(display_short)|uniprotkb:TPSB1(gene name synonym)|uniprotkb:Tryptase I(gene name synonym)|uniprotkb:TPS1(gene name synonym)|uniprotkb:TPS2(gene name synonym)|uniprotkb:Tryptase alpha-1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25489276|imex:IM-27830-248 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7843867(chain-parent)|uniprotkb:P0C6X7(chain-parent) refseq:NP_003285.2|ensembl:ENSG00000172236(gene)|ensembl:ENST00000338844(transcript)|ensembl:ENST00000677899(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006508"(proteolysis)|go:"GO:0006952"(defense response)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0042802"(identical protein binding)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR018114|interpro:IPR033116|interpro:IPR043504|rcsb pdb:1LTO|rcsb pdb:2F9N|rcsb pdb:2F9O|rcsb pdb:2F9P|rcsb pdb:2ZEB|rcsb pdb:2ZEC|rcsb pdb:4A6L|rcsb pdb:4MPU|rcsb pdb:4MPV|rcsb pdb:4MPW|rcsb pdb:4MPX|rcsb pdb:4MQA|rcsb pdb:5F03|rcsb pdb:5WI6|rcsb pdb:6O1F|rcsb pdb:6P0P|rcsb pdb:6VVU|reactome:R-HSA-1592389 - chain-seq-start:1|chain-seq-end:180 - figure legend:ST1|comment:the Z-score of this interaction is 1.1|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2020/03/19 2020/03/30 rogid:qbwEpGmE3J035KnL6QbEZ/HRJAw694009 rogid:I/QoDM5Sfej1YpvO9kbj9/wUwBI9606 rigid:0xvPaEOkirGwGOEuuSN/RSvNiPo false protein a tag:n-n renilla luciferase protein tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P0C6X7-PRO_0000037319 uniprotkb:Q8N488 intact:EBI-25487926 intact:EBI-752324|uniprotkb:Q9P2W5|uniprotkb:Q9UMW4|ensembl:ENSP00000419494 psi-mi:p0c6x7-pro_0000037319(display_long)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)|uniprotkb:rep(gene name)|psi-mi:rep(display_short) psi-mi:rybp_human(display_long)|uniprotkb:Death effector domain-associated factor(gene name synonym)|uniprotkb:YY1 and E4TF1-associated factor 1(gene name synonym)|uniprotkb:Apoptin-associating protein 1(gene name synonym)|uniprotkb:RYBP(gene name)|psi-mi:RYBP(display_short)|uniprotkb:DEDAF(gene name synonym)|uniprotkb:YEAF1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25489309|imex:IM-27830-192 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:P0C6X7(chain-parent)|intact:EBI-7843867(chain-parent) refseq:NP_036366.3|dip:DIP-41435N|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0007275"(multicellular organism development)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR033774|interpro:IPR036443|interpro:IPR039958|mint:Q8N488|rcsb pdb:3IXS|reactome:R-HSA-8939243|reactome:R-HSA-8953750|ensembl:ENSG00000163602(gene)|ensembl:ENST00000477973(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity) - chain-seq-start:5302|chain-seq-end:5902 - figure legend:ST1|comment:the Z-score of this interaction is 1.3|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2020/03/19 2020/03/30 rogid:p7KzZyyr+yMS7ZiMTBx4VVZRzGc694009 rogid:t9ef8aO/5xEAB3hMlElJCktEIOU9606 rigid:xd3gCCM8MKMUGbRoc+F4cMWNWWU false protein a tag:n-n renilla luciferase protein tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P0C6X7-PRO_0000037312 uniprotkb:Q96GS6 intact:EBI-25487250 intact:EBI-2870273|uniprotkb:Q6PJU2|uniprotkb:A8K0G8|uniprotkb:Q9BWL0|uniprotkb:Q8WUH9|uniprotkb:Q9H7Q9|uniprotkb:D6W5Z9|ensembl:ENSP00000292577|ensembl:ENSP00000504042 psi-mi:p0c6x7-pro_0000037312(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:ab17a_human(display_long)|uniprotkb:ABHD17A(gene name)|psi-mi:ABHD17A(display_short)|uniprotkb:C19orf27(gene name synonym)|uniprotkb:FAM108A1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25489377|imex:IM-27830-134 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7843867(chain-parent) refseq:XP_011526640.1|refseq:XP_016882830.1|refseq:NP_001123583.1|refseq:NP_112490.3|ensembl:ENSG00000129968(gene)|ensembl:ENST00000292577(transcript)|ensembl:ENST00000676686(transcript)|go:"GO:0002084"(protein depalmitoylation)|go:"GO:0005886"(plasma membrane)|go:"GO:0008474"("palmitoyl-(protein) hydrolase activity")|go:"GO:0010008"(endosome membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099033"(anchored component of postsynaptic recycling endosome membrane)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:1902817"(negative regulation of protein localization to microtubule)|go:"GO:1905668"(positive regulation of protein localization to endosome)|interpro:IPR022742|interpro:IPR029058|mint:Q96GS6|reactome:R-HSA-9648002|go:"GO:0016020"(membrane) - chain-seq-start:3241|chain-seq-end:3546 - figure legend:ST1|comment:the Z-score of this interaction is 2.5|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2020/03/19 2020/03/31 rogid:6LbRC/jITHtqNPZLpKst/+pNdOQ694009 rogid:eZ6J8YENMgDhwA9IrEscvsGst+w9606 rigid:Td3JbPoXRZizZndW3JIHVEqnrQw false protein a tag:n-n renilla luciferase protein tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P0C6X7-PRO_0000037311 uniprotkb:Q13064 intact:EBI-25474079 intact:EBI-2340269|ensembl:ENSP00000313881 psi-mi:p0c6x7-pro_0000037311(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:mkrn3_human(display_long)|uniprotkb:MKRN3(gene name)|psi-mi:MKRN3(display_short)|uniprotkb:D15S9(gene name synonym)|uniprotkb:RNF63(gene name synonym)|uniprotkb:ZNF127(gene name synonym)|uniprotkb:Zinc finger protein 127(gene name synonym)|uniprotkb:RING finger protein 63(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase makorin-3(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25489366|imex:IM-27830-252 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7843867(chain-parent) refseq:NP_005655.1|ensembl:ENSG00000179455(gene)|ensembl:ENST00000314520(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003723"(RNA binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000571(Zinc finger, CCCH-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR026294|interpro:IPR031644|interpro:IPR036855|interpro:IPR041367|mint:Q13064 - chain-seq-start:819|chain-seq-end:2740 - figure legend:ST1|comment:the Z-score of this interaction is 1.1|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2020/03/19 2020/03/31 rogid:NKZ5d0D2HjefhmJQwgHz+M1lSt8694009 rogid:3sZzqtO8FoR/vVI64iFKb0iuuSc9606 rigid:g8PaooJ1p46UujDoW3roQMv2N2I false protein a tag:n-n renilla luciferase protein tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P0C6X7-PRO_0000037311 uniprotkb:Q9H000 intact:EBI-25474079 intact:EBI-2341005|uniprotkb:A6NIA2|uniprotkb:Q9BUY2|uniprotkb:B3KRC5|uniprotkb:Q96BD4|uniprotkb:Q8N391|uniprotkb:Q9NRY1|uniprotkb:B4DPR4|intact:EBI-11126681|ensembl:ENSP00000170447|ensembl:ENSP00000502893 psi-mi:p0c6x7-pro_0000037311(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:mkrn2_human(display_long)|uniprotkb:MKRN2(gene name)|psi-mi:MKRN2(display_short)|uniprotkb:RNF62(gene name synonym)|uniprotkb:RING finger protein 62(gene name synonym)|uniprotkb:HSPC070(orf name)|uniprotkb:RING-type E3 ubiquitin transferase makorin-2(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25489355|imex:IM-27830-196 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7843867(chain-parent) refseq:NP_054879.3|refseq:NP_001258636.1|ensembl:ENSG00000075975(gene)|ensembl:ENST00000170447(transcript)|ensembl:ENST00000677816(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000571(Zinc finger, CCCH-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR026293|interpro:IPR036855|interpro:IPR041367|mint:Q9H000 - chain-seq-start:819|chain-seq-end:2740 - figure legend:ST1|comment:the Z-score of this interaction is 1.1|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2020/03/19 2020/03/31 rogid:NKZ5d0D2HjefhmJQwgHz+M1lSt8694009 rogid:ZI7Jr4Fd52sQnfeNXXcZ0NscyD89606 rigid:WE6wZJV6nmECUnNEQbdgMZi3mmY false protein a tag:n-n renilla luciferase protein tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P0C6X7-PRO_0000037312 uniprotkb:P62942 intact:EBI-25487250 intact:EBI-1027571|uniprotkb:P20071|uniprotkb:Q4VC47|uniprotkb:Q6FGD9|uniprotkb:Q6LEU3|uniprotkb:Q9H103|uniprotkb:Q9H566|uniprotkb:D3DVW6|ensembl:ENSP00000371138|ensembl:ENSP00000371143|ensembl:ENSP00000383003|ensembl:ENSP00000503033|ensembl:ENSP00000503152 psi-mi:p0c6x7-pro_0000037312(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:fkb1a_human(display_long)|uniprotkb:FKBP1A(gene name)|psi-mi:FKBP1A(display_short)|uniprotkb:FKBP1(gene name synonym)|uniprotkb:FKBP12(gene name synonym)|uniprotkb:FK506-binding protein 1A(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:Immunophilin FKBP12(gene name synonym)|uniprotkb:12 kDa FK506-binding protein(gene name synonym)|uniprotkb:Calstabin-1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25489388|imex:IM-27830-94 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7843867(chain-parent) ensembl:ENSG00000088832(gene)|ensembl:ENST00000381719(transcript)|ensembl:ENST00000381724(transcript)|ensembl:ENST00000400137(transcript)|ensembl:ENST00000677335(transcript)|ensembl:ENST00000678408(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005527"(macrolide binding)|go:"GO:0005528"(FK506 binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006458"('de novo' protein folding)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0014802"(terminal cisterna)|go:"GO:0016020"(membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0030018"(Z disc)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031312"(extrinsic component of organelle membrane)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032925"(regulation of activin receptor signaling pathway)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0042026"(protein refolding)|go:"GO:0042110"(T cell activation)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0046332"(SMAD binding)|go:"GO:0048185"(activin binding)|go:"GO:0050776"(regulation of immune response)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0060347"(heart trabecula formation)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0098562"(cytoplasmic side of membrane)|go:"GO:1902991"(regulation of amyloid precursor protein catabolic process)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990425"(ryanodine receptor complex)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|rcsb pdb:1A7X|rcsb pdb:1B6C|rcsb pdb:1BKF|rcsb pdb:1BL4|rcsb pdb:1D6O|rcsb pdb:1D7H|rcsb pdb:1D7I|rcsb pdb:1D7J|rcsb pdb:1EYM|rcsb pdb:1F40|rcsb pdb:1FAP|rcsb pdb:1FKB|rcsb pdb:1FKD|rcsb pdb:1FKF|rcsb pdb:1FKG|rcsb pdb:1FKH|rcsb pdb:1FKI|rcsb pdb:2DG4|rcsb pdb:2DG9|rcsb pdb:2FAP|rcsb pdb:2FKE|rcsb pdb:2ND5|rcsb pdb:2PPN|rcsb pdb:2PPO|rcsb pdb:2PPP|rcsb pdb:2RSE|rcsb pdb:3FAP|rcsb pdb:1FKJ|rcsb pdb:3H9R|rcsb pdb:3MDY|rcsb pdb:4DH0|rcsb pdb:4FAP|rcsb pdb:1FKR|rcsb pdb:4IPX|rcsb pdb:4N19|rcsb pdb:4ODP|rcsb pdb:4ODQ|rcsb pdb:4ODR|rcsb pdb:5I7P|rcsb pdb:5I7Q|rcsb pdb:6I1S|rcsb pdb:1FKS|rcsb pdb:6M4U|rcsb pdb:6OQA|rcsb pdb:6VCU|rcsb pdb:6YF0|rcsb pdb:6YF1|rcsb pdb:6YF2|rcsb pdb:6YF3|reactome:R-HSA-166208|rcsb pdb:1FKT|reactome:R-HSA-2025928|reactome:R-HSA-2173789|reactome:R-HSA-2173791|reactome:R-HSA-3656535|rcsb pdb:1J4H|rcsb pdb:1J4I|reactome:R-HSA-9679191|rcsb pdb:1J4R|rcsb pdb:1NSG|rcsb pdb:1QPF|rcsb pdb:1QPL|rcsb pdb:2DG3|refseq:NP_000792.1|refseq:NP_463460.1|dip:DIP-29710N - chain-seq-start:3241|chain-seq-end:3546 - figure legend:ST1|comment:the Z-score of this interaction is 1.2|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2020/03/19 2020/03/31 rogid:6LbRC/jITHtqNPZLpKst/+pNdOQ694009 rogid:3eikHNIIVs8AFM7PYVWurI/9KUY9606 rigid:tN0D9V6gTu1mE7225pfgQh4JZNw false protein a tag:n-n renilla luciferase protein tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6S8E0 uniprotkb:P60866 intact:EBI-25489144|uniprotkb:Q19QV9 intact:EBI-353105|uniprotkb:P17075|uniprotkb:Q5M8S9|uniprotkb:B2R4F4|uniprotkb:B4DW28|ensembl:ENSP00000009589|ensembl:ENSP00000427788|ensembl:ENSP00000503327|ensembl:ENSP00000504123|ensembl:ENSP00000504154|ensembl:ENSP00000504670 psi-mi:q6s8e0_sars(display_long)|uniprotkb:ORF9b(gene name)|psi-mi:ORF9b(display_short)|uniprotkb:sars9b(gene name synonym)|uniprotkb:ORF-9b(gene name synonym)|uniprotkb:Protein 9b(gene name synonym) psi-mi:rs20_human(display_long)|uniprotkb:RPS20(gene name)|psi-mi:RPS20(display_short)|uniprotkb:Small ribosomal subunit protein uS10(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25489564|imex:IM-27830-256 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005737"(cytoplasm)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR018542|interpro:IPR037223|refseq:NP_828859.1 refseq:NP_001014.1|refseq:NP_001139699.1|dip:DIP-31245N|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|ensembl:ENSG00000008988(gene)|ensembl:ENST00000009589(transcript)|ensembl:ENST00000521262(transcript)|ensembl:ENST00000676461(transcript)|ensembl:ENST00000676918(transcript)|ensembl:ENST00000678039(transcript)|ensembl:ENST00000678683(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0016020"(membrane)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0045202"(synapse)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:1901798"(positive regulation of signal transduction by p53 class mediator)|go:"GO:1990948"(ubiquitin ligase inhibitor activity)|interpro:IPR001848(Ribosomal protein S10)|interpro:IPR005729(Ribosomal protein S10, eukaryotic/archaeal)|interpro:IPR018268|interpro:IPR027486|interpro:IPR036838|mint:P60866|rcsb pdb:4UG0|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBS|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOL|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957 - - - figure legend:ST1|comment:the Z-score of this interaction is 1.2|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2020/03/19 2020/03/30 rogid:ZEzTkfwAYVAO0h/WLJJYeWYudyk694009 rogid:6xNxX+eP59AOm0KraCysRHUqMFw9606 rigid:4MXZZQu4jzmxJhy+H890lIhoFvk false protein a tag:n-n renilla luciferase protein tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q19QW2 uniprotkb:P46379 intact:EBI-25489121|uniprotkb:Q6S8E3|uniprotkb:Q6T9E4|uniprotkb:Q7T694|uniprotkb:Q7T6Q6|uniprotkb:Q7T6Q9|uniprotkb:Q7T6R3|uniprotkb:Q7T6R7|uniprotkb:Q7T6S1|uniprotkb:Q7TA23 intact:EBI-347552|uniprotkb:A2ADJ7|uniprotkb:A3KQ42|uniprotkb:A3KQ44|uniprotkb:A6NGY6|uniprotkb:A6PWF7|uniprotkb:O95874|uniprotkb:Q5HYL9|uniprotkb:Q5SQ35|uniprotkb:Q5SQ36|uniprotkb:Q5SQ37|uniprotkb:Q5SQ41|uniprotkb:Q5SRP8|uniprotkb:Q5SRP9|uniprotkb:Q5STC1|uniprotkb:Q5STX1|uniprotkb:Q5STX3|uniprotkb:Q96SA6|uniprotkb:Q9BCN4|uniprotkb:B0UX84|uniprotkb:B4DZ12|uniprotkb:B4E3V4|uniprotkb:E7EMZ4|uniprotkb:F8VXY4|ensembl:ENSP00000354368|ensembl:ENSP00000390966|ensembl:ENSP00000397894 psi-mi:q19qw2_sars(display_long)|uniprotkb:orf8a(gene name)|psi-mi:orf8a(display_short)|uniprotkb:sars8a(gene name synonym) psi-mi:bag6_human(display_long)|uniprotkb:BAT3(gene name synonym)|uniprotkb:G3(gene name synonym)|uniprotkb:HLA-B-associated transcript 3(gene name synonym)|uniprotkb:Protein G3(gene name synonym)|uniprotkb:BCL2-associated athanogene 6(gene name synonym)|uniprotkb:BAG6(gene name)|psi-mi:BAG6(display_short)|uniprotkb:BAG family molecular chaperone regulator 6(gene name synonym)|uniprotkb:Protein Scythe(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25489531|imex:IM-27830-156 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR022722|refseq:NP_849176.1 dip:DIP-31191N|refseq:NP_001092004.1|refseq:NP_001186627.1|refseq:NP_004630.3|refseq:NP_542433.1|refseq:NP_542434.1|refseq:NP_001186626.1|refseq:XP_016866776.1|ensembl:ENSG00000096155(gene)|ensembl:ENSG00000229524(gene)|ensembl:ENSG00000233348(gene)|ensembl:ENST00000361076(transcript)|ensembl:ENST00000449450(transcript)|ensembl:ENST00000451932(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0002429"(immune response-activating cell surface receptor signaling pathway)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016020"(membrane)|go:"GO:0018393"(internal peptidyl-lysine acetylation)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0043022"(ribosome binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0050821"(protein stabilization)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0061857"(endoplasmic reticulum stress-induced pre-emptive quality control)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070628"(proteasome binding)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0071818"(BAT3 complex)|go:"GO:1904294"(positive regulation of ERAD pathway)|go:"GO:1904378"(maintenance of unfolded protein involved in ERAD pathway)|go:"GO:1904379"(protein localization to cytosolic proteasome complex involved in ERAD pathway)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR019954|interpro:IPR021925|interpro:IPR029071|mint:P46379|rcsb pdb:1WX9|rcsb pdb:2N9P|rcsb pdb:4DWF|rcsb pdb:4EEW|rcsb pdb:4WWR|rcsb pdb:6AU8|reactome:R-HSA-9609523|rcsb pdb:4X86 - - - figure legend:ST1|comment:the Z-score of this interaction is 2|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2020/03/19 2020/03/31 rogid:Qi1RZccwqrBJVwiaxXlOG6EDqIk694009 rogid:ghHlLBbS3yeP2mN6AOoHs+CECKU9606 rigid:DOsY24+PiYDgxLstYMv3GU9XtVk false protein a tag:n-n renilla luciferase protein tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P59634 uniprotkb:Q13561 intact:EBI-25489038|uniprotkb:Q7T6R9|uniprotkb:Q7TA25|uniprotkb:Q7TFA7|uniprotkb:Q80BV3 intact:EBI-715074|uniprotkb:Q86YN2|uniprotkb:Q9BW17|uniprotkb:B2RBK5|ensembl:ENSP00000447824 psi-mi:ns6_sars(display_long)|uniprotkb:Accessory protein 6(gene name synonym)|uniprotkb:Protein X3(gene name synonym)|uniprotkb:6(orf name)|uniprotkb:Non-structural protein 6(gene name synonym) psi-mi:dctn2_human(display_long)|uniprotkb:Dynactin complex 50 kDa subunit(gene name synonym)|uniprotkb:50 kDa dynein-associated polypeptide(gene name synonym)|uniprotkb:p50 dynamitin(gene name synonym)|uniprotkb:DCTN2(gene name)|psi-mi:DCTN2(display_short)|uniprotkb:DCTN50(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25489498|imex:IM-27830-254 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016020"(membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039563"(suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044178"(host cell Golgi membrane)|interpro:IPR022736|refseq:NP_828856.1 refseq:NP_006391.1|refseq:NP_001248341.1|refseq:NP_001248342.1|dip:DIP-37545N|reactome:R-HSA-2565942|reactome:R-HSA-3371497|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-6807878|reactome:R-HSA-6811436|reactome:R-HSA-8854518|ensembl:ENSG00000175203(gene)|ensembl:ENST00000548249(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005869"(dynactin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030286"(dynein complex)|go:"GO:0030426"(growth cone)|go:"GO:0030507"(spectrin binding)|go:"GO:0031982"(vesicle)|go:"GO:0032402"(melanosome transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071539"(protein localization to centrosome)|interpro:IPR028133|mint:Q13561|reactome:R-HSA-2132295 - - - figure legend:ST1|comment:the Z-score of this interaction is 1.8|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2020/03/19 2020/03/30 rogid:FbI4KIsNxOBCtk9JMPiabQsxtXM694009 rogid:JrL5jUtArek+zqmCkPKomnjuSf09606 rigid:xPSMv6ZfJOEdAfEalOAr6JHrm74 false protein a tag:n-n renilla luciferase protein tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q7T6S2 uniprotkb:P49069 intact:EBI-25489089|uniprotkb:Q19QW3|uniprotkb:Q6S8E4|uniprotkb:Q6T9E5|uniprotkb:Q7T695|uniprotkb:Q7T6Q7|uniprotkb:Q7T6R0|uniprotkb:Q7T6R4|uniprotkb:Q7T6R8|uniprotkb:Q7TA24 intact:EBI-1748958|uniprotkb:A1L3Y3|ensembl:ENSP00000297156 psi-mi:q7t6s2_sars(display_long)|uniprotkb:orf7b(gene name)|psi-mi:orf7b(display_short)|uniprotkb:NS7b(gene name synonym)|uniprotkb:sars7b(gene name synonym) psi-mi:camlg_human(display_long)|uniprotkb:CAMLG(gene name)|psi-mi:CAMLG(display_short)|uniprotkb:CAML(gene name synonym)|uniprotkb:Calcium signal-modulating cyclophilin ligand(gene name synonym)|uniprotkb:GET2(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25489520|imex:IM-27830-214 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016021"(integral component of membrane)|go:"GO:0033644"(host cell membrane)|interpro:IPR044394|interpro:IPR021532|refseq:NP_849175.1 refseq:NP_001736.1|ensembl:ENSG00000164615(gene)|ensembl:ENST00000297156(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006952"(defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0043529"(GET complex)|go:"GO:0050821"(protein stabilization)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|interpro:IPR016719(Calcium signal-modulating cyclophilin ligand)|rcsb pdb:6SO5|reactome:R-HSA-9609523 - - - figure legend:ST1|comment:the Z-score of this interaction is 1.5|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2020/03/19 2020/03/30 rogid:Upm5Q0uPKGlq3LcK5EspPTD7Fc4694009 rogid:BUKJ1VPumP1iJJnr485rxWzEyK49606 rigid:eJMnw13uwgjlkVPIEQVe3UIg/N8 false protein a tag:n-n renilla luciferase protein tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q19QW4 uniprotkb:Q9BQB6 intact:EBI-25489066|uniprotkb:J9T0F7 intact:EBI-6256462|ensembl:ENSP00000378426|uniprotkb:A6NIQ6|uniprotkb:B2R4Z6|uniprotkb:Q6UX90|uniprotkb:Q7Z2R4 psi-mi:q19qw4_sars(display_long)|uniprotkb:ORF7a(gene name)|psi-mi:ORF7a(display_short) psi-mi:vkor1_human(display_long)|uniprotkb:VKORC1(gene name)|psi-mi:VKORC1(display_short)|uniprotkb:VKOR(gene name synonym)|uniprotkb:Vitamin K1 2,3-epoxide reductase subunit 1(gene name synonym)|uniprotkb:MSTP134(orf name)|uniprotkb:MSTP576(orf name)|uniprotkb:UNQ308/PRO351(orf name) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25489509|imex:IM-27830-154 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR044871|go:"GO:0016021"(integral component of membrane)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0039646"(modulation by virus of host G0/G1 transition checkpoint)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044173"(host cell endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0044178"(host cell Golgi membrane)|interpro:IPR014888(SARS coronavirus X4 like)|interpro:IPR036495|refseq:NP_828857.1 ensembl:ENSG00000167397(gene)|ensembl:ENST00000394975(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0007596"(blood coagulation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017144"|go:"GO:0017187"(peptidyl-glutamic acid carboxylation)|go:"GO:0042373"(vitamin K metabolic process)|go:"GO:0047057"("vitamin-K-epoxide reductase (warfarin-sensitive) activity")|go:"GO:0048038"(quinone binding)|go:"GO:0060348"(bone development)|interpro:IPR012932(Vitamin K epoxide reductase)|interpro:IPR038354|interpro:IPR042406|mint:Q9BQB6|rcsb pdb:6WV3|rcsb pdb:6WV4|rcsb pdb:6WV5|rcsb pdb:6WV6|rcsb pdb:6WV7|rcsb pdb:6WVH|reactome:R-HSA-6806664|refseq:NP_001298240.1|refseq:NP_076869.1|refseq:NP_996560.1 - - - figure legend:ST1|comment:the Z-score of this interaction is 1.5|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2020/03/19 2020/03/30 rogid:Es9fKGNXTAgB+97mHmPWTjXL8nU694009 rogid:C3RrQ+y7Huai7PExa9LOvfqni+U9606 rigid:esHBpOZyjDO5MRN77CDyzPNEmjs false protein a tag:n-n renilla luciferase protein tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6S8E0 uniprotkb:P27448 intact:EBI-25489144|uniprotkb:Q19QV9 intact:EBI-707595|uniprotkb:O60219|uniprotkb:Q8TB41|uniprotkb:Q8WX83|uniprotkb:Q96RG1|uniprotkb:Q9UMY9|uniprotkb:Q9UN34|uniprotkb:Q86TT8|uniprotkb:A0A0A0MQR8|uniprotkb:A0A0A0MST9|uniprotkb:A0A0A0MT23|ensembl:ENSP00000411397 psi-mi:q6s8e0_sars(display_long)|uniprotkb:ORF9b(gene name)|psi-mi:ORF9b(display_short)|uniprotkb:sars9b(gene name synonym)|uniprotkb:ORF-9b(gene name synonym)|uniprotkb:Protein 9b(gene name synonym) psi-mi:mark3_human(display_long)|uniprotkb:Cdc25C-associated protein kinase 1(gene name synonym)|uniprotkb:C-TAK1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase p78(gene name synonym)|uniprotkb:Ser/Thr protein kinase PAR-1(gene name synonym)|uniprotkb:Protein kinase STK10(gene name synonym)|uniprotkb:MARK3(gene name)|psi-mi:MARK3(display_short)|uniprotkb:CTAK1(gene name synonym)|uniprotkb:EMK2(gene name synonym)|uniprotkb:ELKL motif kinase 2(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25489542|imex:IM-27830-96 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005737"(cytoplasm)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR018542|interpro:IPR037223|refseq:NP_828859.1 refseq:NP_001122390.2|refseq:NP_001122391.2|refseq:NP_001122392.2|refseq:NP_001122393.2|refseq:NP_002367.5|dip:DIP-34637N|ensembl:ENSG00000075413(gene)|ensembl:ENST00000429436(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030425"(dendrite)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0048156"(tau protein binding)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001772(Kinase-associated KA1)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|interpro:IPR033628|mint:P27448|rcsb pdb:2QNJ|rcsb pdb:3FE3|rcsb pdb:7O94|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223 - - - figure legend:ST1|comment:the Z-score of this interaction is 2.7|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2020/03/19 2020/03/30 rogid:ZEzTkfwAYVAO0h/WLJJYeWYudyk694009 rogid:YoMdp32OqT0OCgUUBwxSEHmA+vs9606 rigid:VIwBKf7RysHGpB3rQkcPvOP5LIo false protein a tag:n-n renilla luciferase protein tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P0C6X7-PRO_0000037316 uniprotkb:Q9UQN3 intact:EBI-25475825 intact:EBI-718324|uniprotkb:Q53HC7|uniprotkb:Q9Y4U6|intact:EBI-11161391|uniprotkb:B4DJG8|ensembl:ENSP00000263780 psi-mi:p0c6x7-pro_0000037316(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:chm2b_human(display_long)|uniprotkb:Chromatin-modifying protein 2b(gene name synonym)|uniprotkb:CHMP2.5(gene name synonym)|uniprotkb:Vacuolar protein sorting-associated protein 2-2(gene name synonym)|uniprotkb:CHMP2B(gene name)|psi-mi:CHMP2B(display_short)|uniprotkb:CGI-84(orf name) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25489454|imex:IM-27830-136 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7843867(chain-parent) refseq:NP_054762.2|refseq:NP_001231573.1|ensembl:ENSG00000083937(gene)|ensembl:ENST00000263780(transcript)|go:"GO:0000815"(ESCRT III complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005771"(multivesicular body)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0006997"(nucleus organization)|go:"GO:0007032"(endosome organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016236"(macroautophagy)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032509"(endosome transport via multivesicular body sorting pathway)|go:"GO:0036258"(multivesicular body assembly)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0045296"(cadherin binding)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0050890"(cognition)|go:"GO:0061763"(multivesicular body-lysosome fusion)|go:"GO:0061952"(midbody abscission)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099159"(regulation of modification of postsynaptic structure)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:1901673"(regulation of mitotic spindle assembly)|go:"GO:1902188"(obsolete positive regulation of viral release from host cell)|go:"GO:1904903"(ESCRT III complex disassembly)|interpro:IPR005024(Snf7)|mint:Q9UQN3|rcsb pdb:2JQK|reactome:R-HSA-162588|reactome:R-HSA-1632852|reactome:R-HSA-5620971|reactome:R-HSA-917729|reactome:R-HSA-9610379|reactome:R-HSA-9615710|reactome:R-HSA-9668328|reactome:R-HSA-9679504|reactome:R-HSA-9694676|go:"GO:0010824"(regulation of centrosome duplication)|dip:DIP-50766N - chain-seq-start:4118|chain-seq-end:4230 - figure legend:ST1|comment:the Z-score of this interaction is 1.1|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2020/03/19 2020/03/30 rogid:djbtL5LNKDagWRnaJOlJM8BS5lU694009 rogid:WmtZzxKkbkLsgFov/DJDKKGvIto9606 rigid:60pjZMccWoR9uPnbaHt6Vl7ufMo false protein a tag:n-n renilla luciferase protein tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P0C6X7-PRO_0000037314 uniprotkb:O95865 intact:EBI-25487672 intact:EBI-749139|uniprotkb:A2BEZ7|ensembl:ENSP00000364943|ensembl:ENSP00000364945|ensembl:ENSP00000364949|ensembl:ENSP00000372901|ensembl:ENSP00000382935|ensembl:ENSP00000389552|ensembl:ENSP00000391632|ensembl:ENSP00000391833|ensembl:ENSP00000395372|ensembl:ENSP00000395759|ensembl:ENSP00000397466|ensembl:ENSP00000399023|ensembl:ENSP00000399357|ensembl:ENSP00000402594|ensembl:ENSP00000403154|ensembl:ENSP00000404342|ensembl:ENSP00000404851|ensembl:ENSP00000405515|ensembl:ENSP00000408148|ensembl:ENSP00000409396|ensembl:ENSP00000412327|ensembl:ENSP00000412800|ensembl:ENSP00000382936 psi-mi:p0c6x7-pro_0000037314(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:ddah2_human(display_long)|uniprotkb:DDAHII(gene name synonym)|uniprotkb:Dimethylargininase-2(gene name synonym)|uniprotkb:S-phase protein(gene name synonym)|uniprotkb:Protein G6a(gene name synonym)|uniprotkb:DDAH2(gene name)|psi-mi:DDAH2(display_short)|uniprotkb:DDAH(gene name synonym)|uniprotkb:G6A(gene name synonym)|uniprotkb:NG30(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25489399|imex:IM-27830-114 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7843867(chain-parent)|uniprotkb:P0C6X7(chain-parent) ensembl:ENSG00000206395(gene)|ensembl:ENSG00000213722(gene)|ensembl:ENSG00000225635(gene)|ensembl:ENSG00000226634(gene)|ensembl:ENSG00000227317(gene)|ensembl:ENSG00000228128(gene)|ensembl:ENSG00000233076(gene)|refseq:NP_039268.1|refseq:XP_011512750.1|refseq:NP_001289936.1|refseq:NP_001289937.1|ensembl:ENST00000375787(transcript)|ensembl:ENST00000375789(transcript)|ensembl:ENST00000375792(transcript)|ensembl:ENST00000383409(transcript)|ensembl:ENST00000437889(transcript)|ensembl:ENST00000400062(transcript)|ensembl:ENST00000400063(transcript)|ensembl:ENST00000411456(transcript)|ensembl:ENST00000413532(transcript)|ensembl:ENST00000413655(transcript)|ensembl:ENST00000414455(transcript)|ensembl:ENST00000416410(transcript)|ensembl:ENST00000443533(transcript)|ensembl:ENST00000424790(transcript)|ensembl:ENST00000426149(transcript)|ensembl:ENST00000444699(transcript)|ensembl:ENST00000447101(transcript)|ensembl:ENST00000451411(transcript)|ensembl:ENST00000454138(transcript)|ensembl:ENST00000427126(transcript)|go:"GO:0000052"(citrulline metabolic process)|ensembl:ENST00000430482(transcript)|go:"GO:0003824"(catalytic activity)|go:"GO:0005739"(mitochondrion)|ensembl:ENST00000434464(transcript)|ensembl:ENST00000436437(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006525"(arginine metabolic process)|go:"GO:0006527"(arginine catabolic process)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0016403"(dimethylargininase activity)|go:"GO:0016597"(amino acid binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR033199|interpro:IPR033202|reactome:R-HSA-203615|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process) - chain-seq-start:3837|chain-seq-end:3919 - figure legend:ST1|comment:the Z-score of this interaction is 1.8|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2020/03/19 2020/03/30 rogid:95nEGuIgfxXAK4CVWXC+sH1eT+c694009 rogid:u/xau/wTFcLGsICADPBRLQWljkk9606 rigid:lQQLKirTmWSfh2oEAFK2xz8hBfw false protein a tag:n-n renilla luciferase protein tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P0C6X7-PRO_0000037315 uniprotkb:Q9P0M6 intact:EBI-25487941 intact:EBI-3922608|uniprotkb:Q5SQT2|ensembl:ENSP00000503835|ensembl:ENSP00000362352 psi-mi:p0c6x7-pro_0000037315(display_long)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)|uniprotkb:rep(gene name)|psi-mi:rep(display_short) psi-mi:h2aw_human(display_long)|uniprotkb:MACROH2A2(gene name)|psi-mi:MACROH2A2(display_short)|uniprotkb:H2AFY2(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25489443|imex:IM-27830-210 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7843867(chain-parent)|uniprotkb:P0C6X7(chain-parent) dip:DIP-48563N|refseq:NP_061119.1|ensembl:ENSG00000099284(gene)|ensembl:ENST00000373255(transcript)|ensembl:ENST00000679349(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000786"(nucleosome)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001740"(Barr body)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006342"|go:"GO:0007420"(brain development)|go:"GO:0007549"(dosage compensation)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0045618"(positive regulation of keratinocyte differentiation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071169"(establishment of protein localization to chromatin)|go:"GO:1901837"(negative regulation of transcription of nucleolar large rRNA by RNA polymerase I)|interpro:IPR002119(Histone H2A)|interpro:IPR002589(Appr-1-p processing)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR021171|interpro:IPR032454|interpro:IPR035796|interpro:IPR043472|rcsb pdb:2XD7|rcsb pdb:6FY5 - chain-seq-start:3920|chain-seq-end:4117 - figure legend:ST1|comment:the Z-score of this interaction is 1.2|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2020/03/19 2020/03/30 rogid:3oIsD98B0aiO0Sqlv5jCglM4pgE694009 rogid:xOLJc5I2oZLPBDLrA5IT2lYBQFM9606 rigid:DmM9WfrTwkp6tKFEFb8RCpbWu5E false protein a tag:n-n renilla luciferase protein tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P0C6X7-PRO_0000037314 uniprotkb:A9UHW6 intact:EBI-25487672 intact:EBI-373498|uniprotkb:Q8N4Q5|intact:EBI-946774|uniprotkb:B4DUM7|uniprotkb:Q9HBL5|ensembl:ENSP00000321625|ensembl:ENSP00000484245 psi-mi:p0c6x7-pro_0000037314(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:mi4gd_human(display_long)|uniprotkb:SLIP1(gene name synonym)|uniprotkb:SLBP-interacting protein 1(gene name synonym)|uniprotkb:MIF4GD(gene name)|psi-mi:MIF4GD(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25489410|imex:IM-27830-208 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7843867(chain-parent)|uniprotkb:P0C6X7(chain-parent) ensembl:ENSG00000125457(gene)|ensembl:ENST00000325102(transcript)|ensembl:ENST00000618645(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008494"(translation activator activity)|go:"GO:0042802"(identical protein binding)|interpro:IPR003890(MIF4G-like, type 3)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|mint:A9UHW6|refseq:NP_001229427.1|refseq:NP_001229429.1|refseq:NP_001229430.1|refseq:NP_065730.2|refseq:XP_005257589.1|refseq:XP_005257590.1|refseq:XP_016880382.1|refseq:XP_016880383.1|refseq:XP_005257587.1 - chain-seq-start:3837|chain-seq-end:3919 - figure legend:ST1|comment:the Z-score of this interaction is 1.7|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2020/03/19 2020/03/30 rogid:95nEGuIgfxXAK4CVWXC+sH1eT+c694009 rogid:fVJrdaWCxDp4EBdc1QyA0lECSGE9606 rigid:cH2SCpClB7KEDbxSVGddxa/RQ0U false protein a tag:n-n renilla luciferase protein tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P0C6X7-PRO_0000037315 uniprotkb:P69849 intact:EBI-25487941 intact:EBI-947048|ensembl:ENSP00000382274|ensembl:ENSP00000483234|ensembl:ENSP00000504325|ensembl:ENSP00000504575 psi-mi:p0c6x7-pro_0000037315(display_long)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)|uniprotkb:rep(gene name)|psi-mi:rep(display_short) psi-mi:nomo3_human(display_long)|uniprotkb:NOMO3(gene name)|psi-mi:NOMO3(display_short)|uniprotkb:pM5 protein 3(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25489421|imex:IM-27830-116 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7843867(chain-parent)|uniprotkb:P0C6X7(chain-parent) refseq:NP_001004067.1|ensembl:ENSG00000103226(gene)|ensembl:ENSG00000278087(gene)|ensembl:ENST00000399336(transcript)|ensembl:ENST00000611106(transcript)|ensembl:ENST00000676846(transcript)|ensembl:ENST00000677777(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0043022"(ribosome binding)|go:"GO:1900108"(negative regulation of nodal signaling pathway)|interpro:IPR008969(Carboxypeptidase-like, regulatory region)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013784(Carbohydrate-binding-like fold)|interpro:IPR041033 - chain-seq-start:3920|chain-seq-end:4117 - figure legend:ST1|comment:the Z-score of this interaction is 2.9|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2020/03/19 2020/03/30 rogid:3oIsD98B0aiO0Sqlv5jCglM4pgE694009 rogid:niOgaMEyjLXQF9fJDpnCnVgDdic9606 rigid:HLSkBgXNAtHNYGHVcJe22QSyQlA false protein a tag:n-n renilla luciferase protein tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P0C6X7-PRO_0000037316 uniprotkb:Q5SQN1 intact:EBI-25475825 intact:EBI-10244848|uniprotkb:Q8TB31|uniprotkb:Q9BT10|uniprotkb:Q5TBZ3|uniprotkb:Q96FE1|uniprotkb:Q8N558|uniprotkb:Q8WV46|uniprotkb:Q96CQ3|uniprotkb:Q8TCW8|uniprotkb:Q96NU3|uniprotkb:Q5HYB5|uniprotkb:Q96I66|uniprotkb:Q9BVB2|uniprotkb:B6EDE0 psi-mi:p0c6x7-pro_0000037316(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:snp47_human(display_long)|uniprotkb:SNAP47(gene name)|psi-mi:SNAP47(display_short)|uniprotkb:C1orf142(gene name synonym)|uniprotkb:Epididymis luminal protein 170(gene name synonym)|uniprotkb:HEL170(gene name synonym)|uniprotkb:SVAP1(gene name synonym)|uniprotkb:Synaptosomal-associated 47 kDa protein(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25489465|imex:IM-27830-212 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7843867(chain-parent) interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR000727(Target SNARE coiled-coil region)|refseq:NP_444280.2|refseq:NP_001310864.1|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0012505"(endomembrane system)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0019905"(syntaxin binding)|go:"GO:0031201"(SNARE complex)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0098793"(presynapse)|refseq:XP_016855720.1|refseq:XP_016855721.1 - chain-seq-start:4118|chain-seq-end:4230 - figure legend:ST1|comment:the Z-score of this interaction is 1.7|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2020/03/19 2020/03/30 rogid:djbtL5LNKDagWRnaJOlJM8BS5lU694009 rogid:hKGKMfU5GPf/qU+vuwByphqX3NA9606 rigid:8lZV1Q3qYOMqxs+K7hQmbixuD7I false protein a tag:n-n renilla luciferase protein tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P0C6X7-PRO_0000037315 uniprotkb:P54274 intact:EBI-25487941 intact:EBI-710997|uniprotkb:A7XP29|uniprotkb:Q15553|uniprotkb:Q93029|ensembl:ENSP00000276603|uniprotkb:Q8NHT6 psi-mi:p0c6x7-pro_0000037315(display_long)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)|uniprotkb:rep(gene name)|psi-mi:rep(display_short) psi-mi:terf1_human(display_long)|uniprotkb:TTAGGG repeat-binding factor 1(gene name synonym)|uniprotkb:NIMA-interacting protein 2(gene name synonym)|uniprotkb:Telomeric protein Pin2/TRF1(gene name synonym)|uniprotkb:TERF1(gene name)|psi-mi:TERF1(display_short)|uniprotkb:PIN2(gene name synonym)|uniprotkb:TRF(gene name synonym)|uniprotkb:TRF1(gene name synonym)|uniprotkb:TRBF1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25489432|imex:IM-27830-74 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7843867(chain-parent)|uniprotkb:P0C6X7(chain-parent) refseq:NP_003209.2|refseq:NP_059523.2|ensembl:ENSG00000147601(gene)|go:"GO:0051301"(cell division)|go:"GO:0051974"(negative regulation of telomerase activity)|ensembl:ENST00000276603(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0001650"(fibrillar center)|go:"GO:0003677"(DNA binding)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0008017"(microtubule binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0008301"(DNA binding, bending)|go:"GO:0016604"(nuclear body)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032214"(negative regulation of telomere maintenance via semi-conservative replication)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045141"(meiotic telomere clustering)|interpro:IPR013867(Telomere repeat binding factor, dimerisation)|interpro:IPR017357(Telomeric repeat-binding factor 1, Pin2)|interpro:IPR017930|interpro:IPR036507|mint:P54274|rcsb pdb:1BA5|rcsb pdb:1H6O|rcsb pdb:1ITY|rcsb pdb:1IV6|rcsb pdb:1W0T|rcsb pdb:3BQO|rcsb pdb:3L82|rcsb pdb:5HKP|rcsb pdb:5WIR|rcsb pdb:5XUP|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-171319|reactome:R-HSA-174411|reactome:R-HSA-174414|reactome:R-HSA-174417|reactome:R-HSA-174430|reactome:R-HSA-174437|reactome:R-HSA-2559586|reactome:R-HSA-9670095|go:"GO:0061820"(telomeric D-loop disassembly)|go:"GO:0070187"(shelterin complex)|go:"GO:0071532"(ankyrin repeat binding)|go:"GO:0090656"(t-circle formation)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1904792"(positive regulation of shelterin complex assembly)|go:"GO:1904850"(negative regulation of establishment of protein localization to telomere)|go:"GO:1904911"(negative regulation of establishment of RNA localization to telomere)|go:"GO:1904914"(negative regulation of establishment of protein-containing complex localization to telomere)|go:"GO:1905778"(negative regulation of exonuclease activity)|go:"GO:1905839"(negative regulation of telomeric D-loop disassembly)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR009057(Homeodomain-like)|dip:DIP-29412N - chain-seq-start:3920|chain-seq-end:4117 - figure legend:ST1|comment:the Z-score of this interaction is 1.1|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2020/03/19 2020/03/30 rogid:3oIsD98B0aiO0Sqlv5jCglM4pgE694009 rogid:3Tjmp8hqEhLBIQqxxWHntpL4hz49606 rigid:mumPt5Wr4ANc1EmtK6oeQIpuzvM false protein a tag:n-n renilla luciferase protein tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6S8E0 uniprotkb:P25787 intact:EBI-25489144|uniprotkb:Q19QV9 intact:EBI-603262|uniprotkb:Q9BU45|ensembl:ENSP00000223321|intact:EBI-1237095|uniprotkb:Q6ICS6 psi-mi:q6s8e0_sars(display_long)|uniprotkb:ORF9b(gene name)|psi-mi:ORF9b(display_short)|uniprotkb:sars9b(gene name synonym)|uniprotkb:ORF-9b(gene name synonym)|uniprotkb:Protein 9b(gene name synonym) psi-mi:psa2_human(display_long)|uniprotkb:PSMA2(gene name)|psi-mi:PSMA2(display_short)|uniprotkb:PSC3(gene name synonym)|uniprotkb:Proteasome component C3(gene name synonym)|uniprotkb:Macropain subunit C3(gene name synonym)|uniprotkb:Multicatalytic endopeptidase complex subunit C3(gene name synonym)|uniprotkb:HC3(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25489553|imex:IM-27830-216 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005737"(cytoplasm)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR018542|interpro:IPR037223|refseq:NP_828859.1 mint:P25787|rcsb pdb:4R3O|rcsb pdb:4R67|rcsb pdb:5A0Q|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LE5|rcsb pdb:5LEX|rcsb pdb:5LEY|rcsb pdb:5LEZ|rcsb pdb:5LF0|rcsb pdb:5LF1|rcsb pdb:5LF3|rcsb pdb:5LF4|rcsb pdb:5LF6|rcsb pdb:5LF7|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|ensembl:ENSG00000106588(gene)|ensembl:ENST00000223321(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0000932"(P-body)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005839"(proteasome core complex)|go:"GO:0009615"(response to virus)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0019773"(proteasome core complex, alpha-subunit complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000426(Proteasome alpha-subunit, conserved site)|interpro:IPR001353(20S proteasome, A and B subunits)|interpro:IPR023332|interpro:IPR029055|interpro:IPR034644|refseq:NP_002778.1|dip:DIP-29364N|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFO|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:6AVO|rcsb pdb:6E5B|rcsb pdb:6KWY|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6R70|rcsb pdb:6REY|rcsb pdb:6RGQ|rcsb pdb:6WJD|rcsb pdb:6WJN|rcsb pdb:6XMJ|rcsb pdb:7AWE|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168 - - - figure legend:ST1|comment:the Z-score of this interaction is 1.1|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2020/03/19 2020/03/30 rogid:ZEzTkfwAYVAO0h/WLJJYeWYudyk694009 rogid:COncAMXXqT+zAHA/nK+7dweRg9A9606 rigid:gWbrpZeJcve8ImVq7xCmMx7VB6g false protein a tag:n-n renilla luciferase protein tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q7TLC7 uniprotkb:O14964 intact:EBI-25488942 intact:EBI-740220|uniprotkb:Q9NR36|ensembl:ENSP00000331201|ensembl:ENSP00000504106 psi-mi:y14_sars(display_long)|uniprotkb:ORF14(orf name) psi-mi:hgs_human(display_long)|uniprotkb:Protein pp110(gene name synonym)|uniprotkb:Hrs(gene name synonym)|uniprotkb:HGS(gene name)|psi-mi:HGS(display_short)|uniprotkb:HRS(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25489476|imex:IM-27830-76 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0042802"(identical protein binding)|interpro:IPR035113 refseq:NP_004703.1|dip:DIP-29050N|ensembl:ENSG00000185359(gene)|ensembl:ENST00000329138(transcript)|ensembl:ENST00000676546(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0007165"(signal transduction)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010324"(membrane invagination)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0016197"(endosomal transport)|go:"GO:0016236"(macroautophagy)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0033565"(ESCRT-0 complex)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0036258"(multivesicular body assembly)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043405"(regulation of MAP kinase activity)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0097013"(phagocytic vesicle lumen)|go:"GO:1903543"(positive regulation of exosomal secretion)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR002014(VHS)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR008942(ENTH/VHS)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017073(Ubiquitin binding protein, Hrs/VPS27)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR024641|mint:O14964|rcsb pdb:2D3G|rcsb pdb:3F1I|rcsb pdb:3OBQ|rcsb pdb:3ZYQ|rcsb pdb:4AVX|reactome:R-HSA-182971|reactome:R-HSA-432720|reactome:R-HSA-5689880|reactome:R-HSA-6807004|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-9013420|reactome:R-HSA-917729|reactome:R-HSA-9635644|reactome:R-HSA-9636383|reactome:R-HSA-9706019 - - - figure legend:ST1|comment:the Z-score of this interaction is 2.4|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2020/03/19 2020/03/30 rogid:neeKhbgFBkd1lYQvsZHB0OOs+lk694009 rogid:z/AnREuqEpyJ9/Zj6JFCJCJem1I9606 rigid:PyUtrebDAsTO5Xsa9OfGoyjIuiw false protein a tag:n-n renilla luciferase protein tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q7TLC7 uniprotkb:Q13561 intact:EBI-25488942 intact:EBI-715074|uniprotkb:Q86YN2|uniprotkb:Q9BW17|uniprotkb:B2RBK5|ensembl:ENSP00000447824 psi-mi:y14_sars(display_long)|uniprotkb:ORF14(orf name) psi-mi:dctn2_human(display_long)|uniprotkb:Dynactin complex 50 kDa subunit(gene name synonym)|uniprotkb:50 kDa dynein-associated polypeptide(gene name synonym)|uniprotkb:p50 dynamitin(gene name synonym)|uniprotkb:DCTN2(gene name)|psi-mi:DCTN2(display_short)|uniprotkb:DCTN50(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Pfefferle et al. (2011) doi:10.1371/journal.ppat.1002331|imex:IM-27830|pubmed:22046132 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-25489487|imex:IM-27830-56 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0042802"(identical protein binding)|interpro:IPR035113 refseq:NP_006391.1|refseq:NP_001248341.1|refseq:NP_001248342.1|dip:DIP-37545N|reactome:R-HSA-2565942|reactome:R-HSA-3371497|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-6807878|reactome:R-HSA-6811436|reactome:R-HSA-8854518|ensembl:ENSG00000175203(gene)|ensembl:ENST00000548249(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005869"(dynactin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030286"(dynein complex)|go:"GO:0030426"(growth cone)|go:"GO:0030507"(spectrin binding)|go:"GO:0031982"(vesicle)|go:"GO:0032402"(melanosome transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071539"(protein localization to centrosome)|interpro:IPR028133|mint:Q13561|reactome:R-HSA-2132295 - - - figure legend:ST1|comment:the Z-score of this interaction is 1.4|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2020/03/19 2020/03/30 rogid:neeKhbgFBkd1lYQvsZHB0OOs+lk694009 rogid:JrL5jUtArek+zqmCkPKomnjuSf09606 rigid:kxbVv05TvGHFzJTpFKpnbbPBhjU false protein a tag:n-n renilla luciferase protein tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)