#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:O60235 uniprotkb:P59594 intact:EBI-7639969|ensembl:ENSP00000283916|intact:MINT-8302106|uniprotkb:Q08AF6 intact:EBI-15582614|intact:EBI-16063777|uniprotkb:Q6QU82|uniprotkb:Q7T696|uniprotkb:Q7TA19|uniprotkb:Q7TFA2|uniprotkb:Q7TFB1|uniprotkb:Q80BV6 psi-mi:tm11d_human(display_long)|uniprotkb:TMPRSS11D(gene name)|psi-mi:TMPRSS11D(display_short)|uniprotkb:Airway trypsin-like protease(gene name synonym)|uniprotkb:HAT(gene name synonym) psi-mi:spike_sars(display_long)|uniprotkb:S(gene name)|psi-mi:S(display_short)|uniprotkb:E2(gene name synonym)|uniprotkb:Peplomer protein(gene name synonym)|uniprotkb:2(orf name) psi-mi:"MI:0435"(protease assay) Bertram et al. (2011) pubmed:21994442|imex:IM-28403 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) psi-mi:"MI:0570"(protein cleavage) psi-mi:"MI:0469"(IntAct) intact:EBI-26364750|imex:IM-28403-1 - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000153802(gene)|ensembl:ENST00000283916(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0008233"(peptidase activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000082(SEA)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR017329(Transmembrane serine proteases, TMPRSS11A)|interpro:IPR018114|interpro:IPR033116|interpro:IPR036364|interpro:IPR043504|refseq:NP_004253.1 go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044173"(host cell endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0046789"(host cell surface receptor binding)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|interpro:IPR002552(Coronavirus S2 glycoprotein)|interpro:IPR018548|interpro:IPR032500|interpro:IPR036326|interpro:IPR042578|interpro:IPR043002|interpro:IPR043473|interpro:IPR043607|interpro:IPR044341|interpro:IPR044370|interpro:IPR044873|interpro:IPR044874|rcsb pdb:1Q4Z|rcsb pdb:1T7G|rcsb pdb:1U4K|rcsb pdb:1WNC|rcsb pdb:1WYY|rcsb pdb:1XJP|rcsb pdb:1ZV7|rcsb pdb:1ZV8|rcsb pdb:1ZVB|rcsb pdb:2AJF|rcsb pdb:2BEQ|rcsb pdb:2BEZ|rcsb pdb:2DD8|rcsb pdb:2FXP|rcsb pdb:2GHV|rcsb pdb:2GHW|rcsb pdb:2RUM|rcsb pdb:2RUN|rcsb pdb:2RUO|rcsb pdb:3BGF|rcsb pdb:3D0G|rcsb pdb:3D0H|rcsb pdb:3D0I|rcsb pdb:3SCI|rcsb pdb:3SCJ|rcsb pdb:3SCK|rcsb pdb:3SCL|rcsb pdb:5WRG|rcsb pdb:5X4S|rcsb pdb:5X58|rcsb pdb:5X5B|rcsb pdb:5XJK|rcsb pdb:5XLR|rcsb pdb:5ZVM|rcsb pdb:6ACC|rcsb pdb:6ACD|rcsb pdb:6ACG|rcsb pdb:6ACK|rcsb pdb:6CRV|rcsb pdb:6CRW|rcsb pdb:6CRX|rcsb pdb:6CRZ|rcsb pdb:6CS0|rcsb pdb:6CS1|rcsb pdb:6CS2|rcsb pdb:6M3W|rcsb pdb:6NB6|rcsb pdb:6NB7|rcsb pdb:6VW1|rcsb pdb:6WAQ|rcsb pdb:7JN5|rcsb pdb:6ACJ|dip:DIP-29105N|reactome:R-HSA-9679509|reactome:R-HSA-9683686|reactome:R-HSA-9683701|refseq:NP_828851.1|reactome:R-HSA-9678110 - comment:mint|comment:homomint - figure legend:1 C/D, 2|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/09/30 2020/10/07 rogid:xoYygedtCMOXPttieFmCKGE47RI9606 rogid:H4uZUhfNNQNcF4O+7CmC50IoAi8694009 rigid:QpD4Ww8sXP02m5LMCJM5cCfe1Yk false his tag:n-n|sufficient binding region:42-418 biological feature:667-668 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0102"(sequence tag identification)|psi-mi:"MI:0113"(western blot)