#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P51451 uniprotkb:Q8NDB2 intact:EBI-2105445|uniprotkb:Q96IN1|uniprotkb:Q16291|ensembl:ENSP00000259089 intact:EBI-2837677|uniprotkb:Q8NB56|uniprotkb:Q8WYN5|uniprotkb:A8K7W8|uniprotkb:B0F3S2|uniprotkb:Q8N5K8|uniprotkb:Q9NWP2|ensembl:ENSP00000320509 psi-mi:blk_human(display_long)|uniprotkb:BLK(gene name)|psi-mi:BLK(display_short)|uniprotkb:B lymphocyte kinase(gene name synonym)|uniprotkb:p55-Blk(gene name synonym) psi-mi:bank1_human(display_long)|uniprotkb:BANK1(gene name)|psi-mi:BANK1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Castillejo-López et al. (2012) imex:IM-28510|pubmed:21978998 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-26447816|imex:IM-28510-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001706.2|ensembl:ENSG00000136573(gene)|ensembl:ENST00000259089(transcript)|go:"GO:0002431"(Fc receptor mediated stimulatory signaling pathway)|go:"GO:0002513"(tolerance induction to self antigen)|go:"GO:0002576"(platelet degranulation)|go:"GO:0002902"(regulation of B cell apoptotic process)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0045087"(innate immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050855"(regulation of B cell receptor signaling pathway)|go:"GO:0070667"(negative regulation of mast cell proliferation)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:2000670"(positive regulation of dendritic cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035853|interpro:IPR036028|interpro:IPR036860|mint:P51451|reactome:R-HSA-8939245|reactome:R-HSA-983695 refseq:NP_001077376.2|refseq:NP_001120979.2|refseq:NP_060405.4|ensembl:ENSG00000153064(gene)|ensembl:ENST00000322953(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0009617"(response to bacterium)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042113"(B cell activation)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050869"(negative regulation of B cell activation)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR017893|interpro:IPR035897|interpro:IPR036770|interpro:IPR041340|refseq:XP_016863826.1 - - - figure legend:Fig. 1A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2020/11/14 2020/11/16 rogid:z6p1emCKpfhFkpk1GysjT8WEj5g9606 rogid:gPC1vBSnrC6JMDRarNZgFBhuaEs9606 rigid:3JrKY2ZHvIW8qzdZnldrjKFBSsI false v5 tag:c-c flag tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P51451 uniprotkb:Q8NDB2 intact:EBI-2105445|uniprotkb:Q96IN1|uniprotkb:Q16291|ensembl:ENSP00000259089 intact:EBI-2837677|uniprotkb:Q8NB56|uniprotkb:Q8WYN5|uniprotkb:A8K7W8|uniprotkb:B0F3S2|uniprotkb:Q8N5K8|uniprotkb:Q9NWP2|ensembl:ENSP00000320509 psi-mi:blk_human(display_long)|uniprotkb:BLK(gene name)|psi-mi:BLK(display_short)|uniprotkb:B lymphocyte kinase(gene name synonym)|uniprotkb:p55-Blk(gene name synonym) psi-mi:bank1_human(display_long)|uniprotkb:BANK1(gene name)|psi-mi:BANK1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Castillejo-López et al. (2012) imex:IM-28510|pubmed:21978998 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-26447825|imex:IM-28510-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001706.2|ensembl:ENSG00000136573(gene)|ensembl:ENST00000259089(transcript)|go:"GO:0002431"(Fc receptor mediated stimulatory signaling pathway)|go:"GO:0002513"(tolerance induction to self antigen)|go:"GO:0002576"(platelet degranulation)|go:"GO:0002902"(regulation of B cell apoptotic process)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0045087"(innate immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050855"(regulation of B cell receptor signaling pathway)|go:"GO:0070667"(negative regulation of mast cell proliferation)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:2000670"(positive regulation of dendritic cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035853|interpro:IPR036028|interpro:IPR036860|mint:P51451|reactome:R-HSA-8939245|reactome:R-HSA-983695 refseq:NP_001077376.2|refseq:NP_001120979.2|refseq:NP_060405.4|ensembl:ENSG00000153064(gene)|ensembl:ENST00000322953(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0009617"(response to bacterium)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042113"(B cell activation)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050869"(negative regulation of B cell activation)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR017893|interpro:IPR035897|interpro:IPR036770|interpro:IPR041340|refseq:XP_016863826.1 - - - figure legend:Fig. 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2020/11/14 2020/11/16 rogid:z6p1emCKpfhFkpk1GysjT8WEj5g9606 rogid:gPC1vBSnrC6JMDRarNZgFBhuaEs9606 rigid:3JrKY2ZHvIW8qzdZnldrjKFBSsI false v5 tag:c-c flag tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P51451 uniprotkb:Q8NDB2 intact:EBI-2105445|uniprotkb:Q96IN1|uniprotkb:Q16291|ensembl:ENSP00000259089 intact:EBI-2837677|uniprotkb:Q8NB56|uniprotkb:Q8WYN5|uniprotkb:A8K7W8|uniprotkb:B0F3S2|uniprotkb:Q8N5K8|uniprotkb:Q9NWP2|ensembl:ENSP00000320509 psi-mi:blk_human(display_long)|uniprotkb:BLK(gene name)|psi-mi:BLK(display_short)|uniprotkb:B lymphocyte kinase(gene name synonym)|uniprotkb:p55-Blk(gene name synonym) psi-mi:bank1_human(display_long)|uniprotkb:BANK1(gene name)|psi-mi:BANK1(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Castillejo-López et al. (2012) imex:IM-28510|pubmed:21978998 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-26447839|imex:IM-28510-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001706.2|ensembl:ENSG00000136573(gene)|ensembl:ENST00000259089(transcript)|go:"GO:0002431"(Fc receptor mediated stimulatory signaling pathway)|go:"GO:0002513"(tolerance induction to self antigen)|go:"GO:0002576"(platelet degranulation)|go:"GO:0002902"(regulation of B cell apoptotic process)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0045087"(innate immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050855"(regulation of B cell receptor signaling pathway)|go:"GO:0070667"(negative regulation of mast cell proliferation)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:2000670"(positive regulation of dendritic cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035853|interpro:IPR036028|interpro:IPR036860|mint:P51451|reactome:R-HSA-8939245|reactome:R-HSA-983695 refseq:NP_001077376.2|refseq:NP_001120979.2|refseq:NP_060405.4|ensembl:ENSG00000153064(gene)|ensembl:ENST00000322953(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0009617"(response to bacterium)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042113"(B cell activation)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050869"(negative regulation of B cell activation)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR017893|interpro:IPR035897|interpro:IPR036770|interpro:IPR041340|refseq:XP_016863826.1 - - - figure legend:Fig 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-daudi)|taxid:9606(Homo sapiens Burkitt's B-cell lymphona cells) - 2020/11/14 2020/11/16 rogid:z6p1emCKpfhFkpk1GysjT8WEj5g9606 rogid:gPC1vBSnrC6JMDRarNZgFBhuaEs9606 rigid:3JrKY2ZHvIW8qzdZnldrjKFBSsI false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P51451 uniprotkb:Q8NDB2 intact:EBI-2105445|uniprotkb:Q96IN1|uniprotkb:Q16291|ensembl:ENSP00000259089 intact:EBI-2837677|uniprotkb:Q8NB56|uniprotkb:Q8WYN5|uniprotkb:A8K7W8|uniprotkb:B0F3S2|uniprotkb:Q8N5K8|uniprotkb:Q9NWP2|ensembl:ENSP00000320509 psi-mi:blk_human(display_long)|uniprotkb:BLK(gene name)|psi-mi:BLK(display_short)|uniprotkb:B lymphocyte kinase(gene name synonym)|uniprotkb:p55-Blk(gene name synonym) psi-mi:bank1_human(display_long)|uniprotkb:BANK1(gene name)|psi-mi:BANK1(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Castillejo-López et al. (2012) imex:IM-28510|pubmed:21978998 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-26447852|imex:IM-28510-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001706.2|ensembl:ENSG00000136573(gene)|ensembl:ENST00000259089(transcript)|go:"GO:0002431"(Fc receptor mediated stimulatory signaling pathway)|go:"GO:0002513"(tolerance induction to self antigen)|go:"GO:0002576"(platelet degranulation)|go:"GO:0002902"(regulation of B cell apoptotic process)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0045087"(innate immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050855"(regulation of B cell receptor signaling pathway)|go:"GO:0070667"(negative regulation of mast cell proliferation)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:2000670"(positive regulation of dendritic cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035853|interpro:IPR036028|interpro:IPR036860|mint:P51451|reactome:R-HSA-8939245|reactome:R-HSA-983695 refseq:NP_001077376.2|refseq:NP_001120979.2|refseq:NP_060405.4|ensembl:ENSG00000153064(gene)|ensembl:ENST00000322953(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0009617"(response to bacterium)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042113"(B cell activation)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050869"(negative regulation of B cell activation)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR017893|interpro:IPR035897|interpro:IPR036770|interpro:IPR041340|refseq:XP_016863826.1 - - - figure legend:Fig 1D|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-b-cell)|taxid:9606(Homo sapiens B cell) - 2020/11/14 2020/11/16 rogid:z6p1emCKpfhFkpk1GysjT8WEj5g9606 rogid:gPC1vBSnrC6JMDRarNZgFBhuaEs9606 rigid:3JrKY2ZHvIW8qzdZnldrjKFBSsI false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P51451 uniprotkb:Q8NDB2 intact:EBI-2105445|uniprotkb:Q96IN1|uniprotkb:Q16291|ensembl:ENSP00000259089 intact:EBI-2837677|uniprotkb:Q8NB56|uniprotkb:Q8WYN5|uniprotkb:A8K7W8|uniprotkb:B0F3S2|uniprotkb:Q8N5K8|uniprotkb:Q9NWP2|ensembl:ENSP00000320509 psi-mi:blk_human(display_long)|uniprotkb:BLK(gene name)|psi-mi:BLK(display_short)|uniprotkb:B lymphocyte kinase(gene name synonym)|uniprotkb:p55-Blk(gene name synonym) psi-mi:bank1_human(display_long)|uniprotkb:BANK1(gene name)|psi-mi:BANK1(display_short) psi-mi:"MI:0663"(confocal microscopy) Castillejo-López et al. (2012) imex:IM-28510|pubmed:21978998 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0486"(UniProt) intact:EBI-26447946|imex:IM-28510-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001706.2|ensembl:ENSG00000136573(gene)|ensembl:ENST00000259089(transcript)|go:"GO:0002431"(Fc receptor mediated stimulatory signaling pathway)|go:"GO:0002513"(tolerance induction to self antigen)|go:"GO:0002576"(platelet degranulation)|go:"GO:0002902"(regulation of B cell apoptotic process)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0045087"(innate immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050855"(regulation of B cell receptor signaling pathway)|go:"GO:0070667"(negative regulation of mast cell proliferation)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:2000670"(positive regulation of dendritic cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035853|interpro:IPR036028|interpro:IPR036860|mint:P51451|reactome:R-HSA-8939245|reactome:R-HSA-983695 refseq:NP_001077376.2|refseq:NP_001120979.2|refseq:NP_060405.4|ensembl:ENSG00000153064(gene)|ensembl:ENST00000322953(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0009617"(response to bacterium)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042113"(B cell activation)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050869"(negative regulation of B cell activation)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR017893|interpro:IPR035897|interpro:IPR036770|interpro:IPR041340|refseq:XP_016863826.1 go:"GO:0005737"(cytoplasm) - - figure legend:Fig. 2C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2020/11/14 2020/11/17 rogid:z6p1emCKpfhFkpk1GysjT8WEj5g9606 rogid:gPC1vBSnrC6JMDRarNZgFBhuaEs9606 rigid:3JrKY2ZHvIW8qzdZnldrjKFBSsI false v5 tag:c-c - - - psi-mi:"MI:1201"(anti-tag immunocytochemistry) psi-mi:"MI:1201"(anti-tag immunocytochemistry) uniprotkb:P51451 uniprotkb:Q8NDB2 intact:EBI-2105445|uniprotkb:Q96IN1|uniprotkb:Q16291|ensembl:ENSP00000259089 intact:EBI-2837677|uniprotkb:Q8NB56|uniprotkb:Q8WYN5|uniprotkb:A8K7W8|uniprotkb:B0F3S2|uniprotkb:Q8N5K8|uniprotkb:Q9NWP2|ensembl:ENSP00000320509 psi-mi:blk_human(display_long)|uniprotkb:BLK(gene name)|psi-mi:BLK(display_short)|uniprotkb:B lymphocyte kinase(gene name synonym)|uniprotkb:p55-Blk(gene name synonym) psi-mi:bank1_human(display_long)|uniprotkb:BANK1(gene name)|psi-mi:BANK1(display_short) psi-mi:"MI:0663"(confocal microscopy) Castillejo-López et al. (2012) imex:IM-28510|pubmed:21978998 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0486"(UniProt) intact:EBI-26447963|imex:IM-28510-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001706.2|ensembl:ENSG00000136573(gene)|ensembl:ENST00000259089(transcript)|go:"GO:0002431"(Fc receptor mediated stimulatory signaling pathway)|go:"GO:0002513"(tolerance induction to self antigen)|go:"GO:0002576"(platelet degranulation)|go:"GO:0002902"(regulation of B cell apoptotic process)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0045087"(innate immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050855"(regulation of B cell receptor signaling pathway)|go:"GO:0070667"(negative regulation of mast cell proliferation)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:2000670"(positive regulation of dendritic cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035853|interpro:IPR036028|interpro:IPR036860|mint:P51451|reactome:R-HSA-8939245|reactome:R-HSA-983695 refseq:NP_001077376.2|refseq:NP_001120979.2|refseq:NP_060405.4|ensembl:ENSG00000153064(gene)|ensembl:ENST00000322953(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0009617"(response to bacterium)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042113"(B cell activation)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050869"(negative regulation of B cell activation)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR017893|interpro:IPR035897|interpro:IPR036770|interpro:IPR041340|refseq:XP_016863826.1 go:"GO:0005737"(cytoplasm) - - figure legend:Supp Fig. 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2020/11/14 2020/11/17 rogid:z6p1emCKpfhFkpk1GysjT8WEj5g9606 rogid:gPC1vBSnrC6JMDRarNZgFBhuaEs9606 rigid:3JrKY2ZHvIW8qzdZnldrjKFBSsI false green fluorescent protein tag:c-c mcherry fluorescent protein tag:c-c - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence)