#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q4ACU6	uniprotkb:Q8BTM8	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	intact:EBI-641991|uniprotkb:B7FAV0|uniprotkb:O54934|uniprotkb:Q7TQI1|uniprotkb:Q8BLK1|uniprotkb:Q8BTN7|uniprotkb:Q8VHX5|uniprotkb:Q8VHX8|uniprotkb:Q99KQ2|ensembl:ENSMUSP00000033699	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:flna_mouse(display_long)|uniprotkb:Alpha-filamin(gene name synonym)|uniprotkb:Filamin-1(gene name synonym)|uniprotkb:Endothelial actin-binding protein(gene name synonym)|uniprotkb:Actin-binding protein 280(gene name synonym)|uniprotkb:Non-muscle filamin(gene name synonym)|uniprotkb:Flna(gene name)|psi-mi:Flna(display_short)|uniprotkb:Fln(gene name synonym)|uniprotkb:Fln1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26367518|imex:IM-28561-181	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	refseq:XP_006527974.1|ensembl:ENSMUST00000033699(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005938"(cell cortex)|go:"GO:0007195"(adenylate cyclase-inhibiting dopamine receptor signaling pathway)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016479"(negative regulation of transcription by RNA polymerase I)|go:"GO:0019900"(kinase binding)|go:"GO:0021943"(formation of radial glial scaffolds)|go:"GO:0021987"(cerebral cortex development)|ensembl:ENSMUSG00000031328(gene)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0046332"(SMAD binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048680"(positive regulation of axon regeneration)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051015"(actin filament binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0051764"(actin crosslink formation)|go:"GO:0060271"(cilium assembly)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090042"(tubulin deacetylation)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0030018"(Z disc)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030426"(growth cone)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031523"(Myb complex)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031852"(mu-type opioid receptor binding)|go:"GO:0032231"(regulation of actin filament bundle assembly)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0032432"(actin filament bundle)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034988"(Fc-gamma receptor I complex binding)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043113"(receptor clustering)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0097440"(apical dendrite)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901381"(positive regulation of potassium ion transmembrane transport)|go:"GO:1902396"(protein localization to bicellular tight junction)|go:"GO:1905000"(regulation of membrane repolarization during atrial cardiac muscle cell action potential)|go:"GO:1905031"(regulation of membrane repolarization during cardiac muscle cell action potential)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2001046"(positive regulation of integrin-mediated signaling pathway)|go:"GO:2001224"(positive regulation of neuron migration)|interpro:IPR001298(Filamin/ABP280 repeat)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|go:"GO:0097368"(establishment of Sertoli cell barrier)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR036872|interpro:IPR044801|mint:Q8BTM8|reactome:R-MMU-114608|reactome:R-MMU-430116|reactome:R-MMU-446353|reactome:R-MMU-5627123	-	-	-	figure legend:sf6|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/10/05	2020/10/12	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rogid:hp3whHs7nFMTtChpQ/KywkPalq810090	rigid:9/ckanYoX4JUU2EdLh7B8qcNKis	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:D3YZU1	uniprotkb:Q99JP6	intact:EBI-2314988|ensembl:ENSMUSP00000103571	intact:EBI-6272061|ensembl:ENSMUSP00000117033|uniprotkb:D3Z6N9|uniprotkb:Q9Z215	psi-mi:shan1_mouse(display_long)|uniprotkb:Shank1(gene name)|psi-mi:Shank1(display_short)	psi-mi:home3_mouse(display_long)|uniprotkb:Homer3(gene name)|psi-mi:Homer3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26367522|imex:IM-28561-401	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001029287.1|refseq:XP_006540927.1|ensembl:ENSMUSG00000038738(gene)|ensembl:ENSMUST00000107938(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007616"(long-term memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008306"(associative learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030425"(dendrite)|go:"GO:0030534"(adult behavior)|go:"GO:0031877"(somatostatin receptor binding)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042048"(olfactory behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046959"(habituation)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0050894"(determination of affect)|go:"GO:0060013"(righting reflex)|go:"GO:0060074"(synapse maturation)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071532"(ankyrin repeat binding)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099173"(postsynapse organization)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|reactome:R-MMU-6794361	ensembl:ENSMUSG00000003573(gene)|ensembl:ENSMUST00000140212(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030425"(dendrite)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0035256"(G protein-coupled glutamate receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045178"(basal part of cell)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2001256"(regulation of store-operated calcium entry)|interpro:IPR000697(EVH1)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR044100|mint:Q99JP6|reactome:R-MMU-6794361|refseq:NP_001139625.1|refseq:NP_036114.2	-	-	-	figure legend:f2c|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/10/05	2020/10/12	rogid:TbxBmjjabypLqTlAx9zbkSAAzpk10090	rogid:7IOPI8VTi6aKK/I0tl4AiUUIXIU10090	rigid:bMjHyF4DBS6jb3lWm/BUIlZ5Tzg	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:D3YZU1	uniprotkb:Q9EP53	intact:EBI-2314988|ensembl:ENSMUSP00000103571	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	psi-mi:shan1_mouse(display_long)|uniprotkb:Shank1(gene name)|psi-mi:Shank1(display_short)	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26367522|imex:IM-28561-401	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001029287.1|refseq:XP_006540927.1|ensembl:ENSMUSG00000038738(gene)|ensembl:ENSMUST00000107938(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007616"(long-term memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008306"(associative learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030425"(dendrite)|go:"GO:0030534"(adult behavior)|go:"GO:0031877"(somatostatin receptor binding)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042048"(olfactory behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046959"(habituation)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0050894"(determination of affect)|go:"GO:0060013"(righting reflex)|go:"GO:0060074"(synapse maturation)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071532"(ankyrin repeat binding)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099173"(postsynapse organization)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|reactome:R-MMU-6794361	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	-	-	-	figure legend:f2c|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/10/05	2020/10/12	rogid:TbxBmjjabypLqTlAx9zbkSAAzpk10090	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rigid:bMjHyF4DBS6jb3lWm/BUIlZ5Tzg	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:D3YZU1	uniprotkb:Q4ACU6	intact:EBI-2314988|ensembl:ENSMUSP00000103571	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	psi-mi:shan1_mouse(display_long)|uniprotkb:Shank1(gene name)|psi-mi:Shank1(display_short)	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26367522|imex:IM-28561-401	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001029287.1|refseq:XP_006540927.1|ensembl:ENSMUSG00000038738(gene)|ensembl:ENSMUST00000107938(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007616"(long-term memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008306"(associative learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030425"(dendrite)|go:"GO:0030534"(adult behavior)|go:"GO:0031877"(somatostatin receptor binding)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042048"(olfactory behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046959"(habituation)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0050894"(determination of affect)|go:"GO:0060013"(righting reflex)|go:"GO:0060074"(synapse maturation)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071532"(ankyrin repeat binding)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099173"(postsynapse organization)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|reactome:R-MMU-6794361	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	-	-	-	figure legend:f2c|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/10/05	2020/10/12	rogid:TbxBmjjabypLqTlAx9zbkSAAzpk10090	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rigid:bMjHyF4DBS6jb3lWm/BUIlZ5Tzg	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q7TPR4	uniprotkb:Q99JP6	intact:EBI-774010|ensembl:ENSMUSP00000021554	intact:EBI-6272061|ensembl:ENSMUSP00000117033|uniprotkb:D3Z6N9|uniprotkb:Q9Z215	psi-mi:actn1_mouse(display_long)|uniprotkb:Alpha-actinin cytoskeletal isoform(gene name synonym)|uniprotkb:Non-muscle alpha-actinin-1(gene name synonym)|uniprotkb:F-actin cross-linking protein(gene name synonym)|uniprotkb:Actn1(gene name)|psi-mi:Actn1(display_short)	psi-mi:home3_mouse(display_long)|uniprotkb:Homer3(gene name)|psi-mi:Homer3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26367529|imex:IM-28561-641	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_598917.1|ensembl:ENSMUSG00000015143(gene)|ensembl:ENSMUST00000021554(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005519"(cytoskeletal regulatory protein binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005916"(fascia adherens)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0017166"(vinculin binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030054"(cell junction)|go:"GO:0030141"(secretory granule)|go:"GO:0030220"(platelet formation)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0032127"(dense core granule membrane)|go:"GO:0036344"(platelet morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051271"(negative regulation of cellular component movement)|go:"GO:0051639"(actin filament network formation)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099186"(structural constituent of postsynapse)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR018247|interpro:IPR036872|mint:Q7TPR4|rcsb pdb:6C0A|reactome:R-MMU-114608|reactome:R-MMU-446388|reactome:R-MMU-9013405|reactome:R-MMU-9013418|reactome:R-MMU-9035034	ensembl:ENSMUSG00000003573(gene)|ensembl:ENSMUST00000140212(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030425"(dendrite)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0035256"(G protein-coupled glutamate receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045178"(basal part of cell)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2001256"(regulation of store-operated calcium entry)|interpro:IPR000697(EVH1)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR044100|mint:Q99JP6|reactome:R-MMU-6794361|refseq:NP_001139625.1|refseq:NP_036114.2	-	-	-	figure legend:f2e|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/10/05	2020/10/12	rogid:02QPrtqpFY8sgQvjRRI5wmCbNjU10090	rogid:7IOPI8VTi6aKK/I0tl4AiUUIXIU10090	rigid:cJiAQ454nyd+56CAhLC10r0HhZA	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q7TPR4	uniprotkb:Q9EP53	intact:EBI-774010|ensembl:ENSMUSP00000021554	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	psi-mi:actn1_mouse(display_long)|uniprotkb:Alpha-actinin cytoskeletal isoform(gene name synonym)|uniprotkb:Non-muscle alpha-actinin-1(gene name synonym)|uniprotkb:F-actin cross-linking protein(gene name synonym)|uniprotkb:Actn1(gene name)|psi-mi:Actn1(display_short)	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26367529|imex:IM-28561-641	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_598917.1|ensembl:ENSMUSG00000015143(gene)|ensembl:ENSMUST00000021554(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005519"(cytoskeletal regulatory protein binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005916"(fascia adherens)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0017166"(vinculin binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030054"(cell junction)|go:"GO:0030141"(secretory granule)|go:"GO:0030220"(platelet formation)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0032127"(dense core granule membrane)|go:"GO:0036344"(platelet morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051271"(negative regulation of cellular component movement)|go:"GO:0051639"(actin filament network formation)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099186"(structural constituent of postsynapse)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR018247|interpro:IPR036872|mint:Q7TPR4|rcsb pdb:6C0A|reactome:R-MMU-114608|reactome:R-MMU-446388|reactome:R-MMU-9013405|reactome:R-MMU-9013418|reactome:R-MMU-9035034	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	-	-	-	figure legend:f2e|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/10/05	2020/10/12	rogid:02QPrtqpFY8sgQvjRRI5wmCbNjU10090	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rigid:cJiAQ454nyd+56CAhLC10r0HhZA	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q7TPR4	uniprotkb:Q4ACU6	intact:EBI-774010|ensembl:ENSMUSP00000021554	intact:EBI-771450|uniprotkb:Q69ZD8|intact:EBI-8401154|intact:MINT-4130064|uniprotkb:F8S0X0|uniprotkb:F8S0X2|uniprotkb:F8S0X3|uniprotkb:F8S0X5|uniprotkb:F8S0X6|uniprotkb:Q9JJZ3|uniprotkb:S6BMD3|uniprotkb:S6CCV8|ensembl:ENSMUSP00000104932	psi-mi:actn1_mouse(display_long)|uniprotkb:Alpha-actinin cytoskeletal isoform(gene name synonym)|uniprotkb:Non-muscle alpha-actinin-1(gene name synonym)|uniprotkb:F-actin cross-linking protein(gene name synonym)|uniprotkb:Actn1(gene name)|psi-mi:Actn1(display_short)	psi-mi:shan3_mouse(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:SPANK-2(gene name synonym)|uniprotkb:Shank3(gene name)|psi-mi:Shank3(display_short)|uniprotkb:Kiaa1650(gene name synonym)|uniprotkb:Prosap2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26367529|imex:IM-28561-641	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_598917.1|ensembl:ENSMUSG00000015143(gene)|ensembl:ENSMUST00000021554(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005519"(cytoskeletal regulatory protein binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005916"(fascia adherens)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0017166"(vinculin binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030054"(cell junction)|go:"GO:0030141"(secretory granule)|go:"GO:0030220"(platelet formation)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0032127"(dense core granule membrane)|go:"GO:0036344"(platelet morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051271"(negative regulation of cellular component movement)|go:"GO:0051639"(actin filament network formation)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099186"(structural constituent of postsynapse)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR018247|interpro:IPR036872|mint:Q7TPR4|rcsb pdb:6C0A|reactome:R-MMU-114608|reactome:R-MMU-446388|reactome:R-MMU-9013405|reactome:R-MMU-9013418|reactome:R-MMU-9035034	refseq:NP_067398.2|dip:DIP-32262N|ensembl:ENSMUSG00000022623(gene)|ensembl:ENSMUST00000109309(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0040011"(locomotion)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1904717"(regulation of AMPA glutamate receptor clustering)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:2000822"(regulation of behavioral fear response)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q4ACU6|rcsb pdb:3O5N|rcsb pdb:5IZU|rcsb pdb:6KYH|rcsb pdb:6KYK|reactome:R-MMU-6794361|reactome:R-MMU-8853659	-	-	-	figure legend:f2e|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/10/05	2020/10/12	rogid:02QPrtqpFY8sgQvjRRI5wmCbNjU10090	rogid:40CZZZ4qetQSv6a6gsUMVeL0c+o10090	rigid:cJiAQ454nyd+56CAhLC10r0HhZA	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9EP53	uniprotkb:D3YZU1	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-2314988|ensembl:ENSMUSP00000103571	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:shan1_mouse(display_long)|uniprotkb:Shank1(gene name)|psi-mi:Shank1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26367535|imex:IM-28561-1541	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852	refseq:NP_001029287.1|refseq:XP_006540927.1|ensembl:ENSMUSG00000038738(gene)|ensembl:ENSMUST00000107938(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007616"(long-term memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008306"(associative learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030425"(dendrite)|go:"GO:0030534"(adult behavior)|go:"GO:0031877"(somatostatin receptor binding)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042048"(olfactory behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046959"(habituation)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0050894"(determination of affect)|go:"GO:0060013"(righting reflex)|go:"GO:0060074"(synapse maturation)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071532"(ankyrin repeat binding)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099173"(postsynapse organization)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|reactome:R-MMU-6794361	-	-	-	figure legend:f2d|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2020/10/05	2020/10/12	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:TbxBmjjabypLqTlAx9zbkSAAzpk10090	rigid:TLFQpvs189udqg2X2DLnAkp7JQI	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q96QS3	uniprotkb:Q9NRD5	intact:EBI-11107474|ensembl:ENSP00000368332	intact:EBI-79165|uniprotkb:O95906|ensembl:ENSP00000349465|ensembl:ENSP00000385205|intact:EBI-2622151|uniprotkb:B3KS52	psi-mi:arx_human(display_long)|uniprotkb:ARX(gene name)|psi-mi:ARX(display_short)|uniprotkb:Aristaless-related homeobox(gene name synonym)	psi-mi:pick1_human(display_long)|uniprotkb:PICK1(gene name)|psi-mi:PICK1(display_short)|uniprotkb:PRKCABP(gene name synonym)|uniprotkb:Protein kinase C-alpha-binding protein(gene name synonym)|uniprotkb:Protein interacting with C kinase 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26508337|imex:IM-28561-183	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_620689.1|ensembl:ENSG00000004848(gene)|ensembl:ENST00000379044(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007411"(axon guidance)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0021759"(globus pallidus development)|go:"GO:0021800"(cerebral cortex tangential migration)|go:"GO:0021831"(embryonic olfactory bulb interneuron precursor migration)|go:"GO:0021846"(cell proliferation in forebrain)|go:"GO:0021853"(cerebral cortex GABAergic interneuron migration)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0044241"(lipid digestion)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0048484"(enteric nervous system development)|go:"GO:0072148"(epithelial cell fate commitment)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR003654(Paired-like homeodomain protein, OAR)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970	ensembl:ENSG00000100151(gene)|ensembl:ENST00000356976(transcript)|ensembl:ENST00000404072(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|refseq:NP_001034672.1|refseq:NP_001034673.1|refseq:NP_036539.1|go:"GO:0015844"(monoamine transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021782"(glial cell development)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0034315"(regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0034316"(negative regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0036294"(cellular response to decreased oxygen levels)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0043113"(receptor clustering)|go:"GO:0045161"(neuronal ion channel clustering)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051015"(actin filament binding)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0098842"(postsynaptic early endosome)|go:"GO:0140090"(membrane curvature sensor activity)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR010504(Arfaptin-like)|interpro:IPR027267|interpro:IPR030798|interpro:IPR036034|interpro:IPR037959|mint:Q9NRD5|rcsb pdb:2GZV|rcsb pdb:6AR4|rcsb pdb:6BJN|rcsb pdb:6BJO|reactome:R-HSA-202733|reactome:R-HSA-416993	-	-	-	figure legend:SF1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2020/10/05	2020/12/11	rogid:rBLZYkByOhAZEXEvFVmWxRB3oN09606	rogid:qRx+eNG7We8Oe0SQOekqpJpn8zk9606	rigid:aP6cWlqNDTXLBAo+WC60J/aLa3U	false	glutathione s tranferase tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P26358	uniprotkb:Q9NRD5	intact:EBI-719459|uniprotkb:Q9UHG5|uniprotkb:Q9ULA2|uniprotkb:Q9UMZ6|uniprotkb:A0AV63|intact:EBI-28971395|ensembl:ENSP00000345739|uniprotkb:B7ZLW6	intact:EBI-79165|uniprotkb:O95906|ensembl:ENSP00000349465|ensembl:ENSP00000385205|intact:EBI-2622151|uniprotkb:B3KS52	psi-mi:dnmt1_human(display_long)|uniprotkb:CXXC9(gene name synonym)|uniprotkb:MCMT(gene name synonym)|uniprotkb:DNA methyltransferase HsaI(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 9(gene name synonym)|uniprotkb:DNMT1(gene name)|psi-mi:DNMT1(display_short)|uniprotkb:AIM(gene name synonym)|uniprotkb:DNMT(gene name synonym)	psi-mi:pick1_human(display_long)|uniprotkb:PICK1(gene name)|psi-mi:PICK1(display_short)|uniprotkb:PRKCABP(gene name synonym)|uniprotkb:Protein kinase C-alpha-binding protein(gene name synonym)|uniprotkb:Protein interacting with C kinase 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26508381|imex:IM-28561-203	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000345739|ensembl:ENST00000359526|ensembl:ENSP00000352516|refseq:NP_001124295.1|refseq:NP_001370.1|ensembl:ENSG00000130816(gene)|ensembl:ENST00000340748(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003886"("DNA (cytosine-5-)-methyltransferase activity")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0006306"(DNA methylation)|go:"GO:0006325"(chromatin organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008270"(zinc ion binding)|reactome:R-HSA-427413|reactome:R-HSA-4655427|reactome:R-HSA-5334118|reactome:R-HSA-9710421|refseq:NP_001305659.1|refseq:NP_001305660.1|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0009008"(DNA-methyltransferase activity)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016458"(obsolete gene silencing)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051573"(negative regulation of histone H3-K9 methylation)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0090309"(positive regulation of DNA methylation-dependent heterochromatin assembly)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905460"(negative regulation of vascular associated smooth muscle cell apoptotic process)|go:"GO:1905931"(negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR001525(C-5 cytosine-specific DNA methylase)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR010506(DMAP1-binding)|interpro:IPR017198("DNA (cytosine-5)-methyltransferase 1")|interpro:IPR018117|interpro:IPR022702|interpro:IPR029063|interpro:IPR031303|interpro:IPR043151|mint:P26358|rcsb pdb:3EPZ|rcsb pdb:3PTA|rcsb pdb:3SWR|rcsb pdb:4WXX|rcsb pdb:4YOC|rcsb pdb:4Z96|rcsb pdb:4Z97|rcsb pdb:5WVO|rcsb pdb:5YDR|rcsb pdb:6K3A|reactome:R-HSA-212300|dip:DIP-39693N	ensembl:ENSG00000100151(gene)|ensembl:ENST00000356976(transcript)|ensembl:ENST00000404072(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|refseq:NP_001034672.1|refseq:NP_001034673.1|refseq:NP_036539.1|go:"GO:0015844"(monoamine transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021782"(glial cell development)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0034315"(regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0034316"(negative regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0036294"(cellular response to decreased oxygen levels)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0043113"(receptor clustering)|go:"GO:0045161"(neuronal ion channel clustering)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051015"(actin filament binding)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0098842"(postsynaptic early endosome)|go:"GO:0140090"(membrane curvature sensor activity)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR010504(Arfaptin-like)|interpro:IPR027267|interpro:IPR030798|interpro:IPR036034|interpro:IPR037959|mint:Q9NRD5|rcsb pdb:2GZV|rcsb pdb:6AR4|rcsb pdb:6BJN|rcsb pdb:6BJO|reactome:R-HSA-202733|reactome:R-HSA-416993	-	-	-	figure legend:SF1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2020/10/05	2020/12/11	rogid:qae3zQwGP5R/+WCWoeahDKZ/9Jg9606	rogid:qRx+eNG7We8Oe0SQOekqpJpn8zk9606	rigid:UX2DJuo/tEsU/irEdu1MFHi98FM	false	glutathione s tranferase tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9GZU7	uniprotkb:Q8ND90	intact:EBI-751587|uniprotkb:Q7Z5Q3|uniprotkb:Q7Z5Q4|uniprotkb:C9IYG0|ensembl:ENSP00000273062	intact:EBI-302345|uniprotkb:O95144|uniprotkb:Q8NG07|ensembl:ENSP00000318914|uniprotkb:A8K4L5	psi-mi:ctds1_human(display_long)|uniprotkb:SCP1(gene name synonym)|uniprotkb:Nuclear LIM interactor-interacting factor 3(gene name synonym)|uniprotkb:CTDSP1(gene name)|psi-mi:CTDSP1(display_short)|uniprotkb:NIF3(gene name synonym)|uniprotkb:NLIIF(gene name synonym)|uniprotkb:Small C-terminal domain phosphatase 1(gene name synonym)	psi-mi:pnma1_human(display_long)|uniprotkb:PNMA1(gene name)|psi-mi:PNMA1(display_short)|uniprotkb:MA1(gene name synonym)|uniprotkb:Neuron- and testis-specific protein 1(gene name synonym)|uniprotkb:37 kDa neuronal protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26508371|imex:IM-28561-201	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001193807.1|refseq:NP_067021.1|refseq:NP_872580.1|dip:DIP-61246N|ensembl:ENSG00000144579(gene)|ensembl:ENST00000273062(transcript)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008420"(RNA polymerase II CTD heptapeptide repeat phosphatase activity)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR004274(NLI interacting factor)|interpro:IPR011948(Dullard-like phosphatase domain)|interpro:IPR023214|interpro:IPR036412|interpro:IPR040078|mint:Q9GZU7|rcsb pdb:1T9Z|rcsb pdb:1TA0|rcsb pdb:2GHQ|rcsb pdb:2GHT|rcsb pdb:3L0B|rcsb pdb:3L0C|rcsb pdb:3L0Y|rcsb pdb:3PGL|rcsb pdb:4YGY|rcsb pdb:4YH1|rcsb pdb:6DU3	refseq:NP_006020.4|ensembl:ENSG00000176903(gene)|ensembl:ENST00000316836(transcript)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0043065"(positive regulation of apoptotic process)|interpro:IPR026523|interpro:IPR026528|mint:Q8ND90	-	-	-	figure legend:SF1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2020/10/05	2020/12/11	rogid:V+4KyPU2ZkPO8pEuJapznDEnoVk9606	rogid:/lx3CB7d/dv4xIgWQrCETPA0Qcw9606	rigid:+yVYuxqM93uKIi99BQWauBQ/QbQ	false	glutathione s tranferase tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q13936	uniprotkb:Q9NRD5	intact:EBI-1038838|uniprotkb:Q13917|uniprotkb:Q13918|uniprotkb:Q13919|uniprotkb:Q13920|uniprotkb:Q13921|uniprotkb:Q13922|uniprotkb:Q13923|uniprotkb:Q13924|uniprotkb:Q13925|uniprotkb:Q13926|uniprotkb:Q13927|uniprotkb:Q13928|uniprotkb:Q13929|uniprotkb:Q13930|uniprotkb:Q13932|uniprotkb:Q13933|uniprotkb:Q14743|uniprotkb:Q14744|uniprotkb:Q15877|uniprotkb:Q4VMI7|uniprotkb:Q4VMI8|uniprotkb:Q4VMI9|uniprotkb:Q6PKM7|uniprotkb:Q8N6C0|uniprotkb:Q99025|uniprotkb:Q99241|uniprotkb:Q99875|uniprotkb:B2RUT3|uniprotkb:E9PDJ0	intact:EBI-79165|uniprotkb:O95906|ensembl:ENSP00000349465|ensembl:ENSP00000385205|intact:EBI-2622151|uniprotkb:B3KS52	psi-mi:cac1c_human(display_long)|uniprotkb:CACNA1C(gene name)|psi-mi:CACNA1C(display_short)|uniprotkb:CACH2(gene name synonym)|uniprotkb:CACN2(gene name synonym)|uniprotkb:CACNL1A1(gene name synonym)|uniprotkb:CCHL1A1(gene name synonym)|uniprotkb:Voltage-gated calcium channel subunit alpha Cav1.2(gene name synonym)|uniprotkb:Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle(gene name synonym)	psi-mi:pick1_human(display_long)|uniprotkb:PICK1(gene name)|psi-mi:PICK1(display_short)|uniprotkb:PRKCABP(gene name synonym)|uniprotkb:Protein kinase C-alpha-binding protein(gene name synonym)|uniprotkb:Protein interacting with C kinase 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26508359|imex:IM-28561-1321	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000710.5|refseq:NP_001123299.1|refseq:NP_001123301.1|refseq:NP_001123303.1|refseq:NP_001123304.1|refseq:NP_001123305.1|refseq:NP_001123306.1|refseq:NP_001123307.1|refseq:NP_001123314.1|refseq:NP_001123315.1|refseq:NP_001123308.1|refseq:NP_001123309.1|refseq:NP_001123310.1|refseq:NP_001123311.1|refseq:NP_001123312.1|refseq:NP_001123313.1|refseq:NP_001123316.1|refseq:NP_001123318.1|refseq:NP_001161095.1|refseq:NP_001161097.1|refseq:NP_001123302.2|refseq:NP_001161096.2|refseq:NP_955630.3|reactome:R-HSA-5576893|reactome:R-HSA-400042|reactome:R-HSA-419037|reactome:R-HSA-422356|go:"GO:0002520"(immune system development)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007507"(heart development)|go:"GO:0008331"(high voltage-gated calcium channel activity)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030425"(dendrite)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035585"(calcium-mediated signaling using extracellular calcium source)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043204"(perikaryon)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0061337"(cardiac conduction)|go:"GO:0061577"(calcium ion transmembrane transport via high voltage-gated calcium channel)|go:"GO:0070509"(calcium ion import)|go:"GO:0086002"(cardiac muscle cell action potential involved in contraction)|go:"GO:0086007"(voltage-gated calcium channel activity involved in cardiac muscle cell action potential)|go:"GO:0086012"(membrane depolarization during cardiac muscle cell action potential)|go:"GO:0086045"(membrane depolarization during AV node cell action potential)|go:"GO:0086056"(voltage-gated calcium channel activity involved in AV node cell action potential)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|go:"GO:0098912"(membrane depolarization during atrial cardiac muscle cell action potential)|go:"GO:1990454"(L-type voltage-gated calcium channel complex)|interpro:IPR002077(Voltage-dependent calcium channel, alpha-1 subunit)|interpro:IPR005446(Voltage-dependent calcium channel, L-type, alpha-1 subunit)|interpro:IPR005451(Voltage-dependent calcium channel, L-type, alpha-1C subunit)|interpro:IPR005821(Ion transport)|interpro:IPR014873(Voltage-dependent calcium channel, alpha-1 subunit, IQ domain)|interpro:IPR027359|interpro:IPR031649|interpro:IPR031688|rcsb pdb:1T0J|rcsb pdb:2BE6|rcsb pdb:2F3Y|rcsb pdb:2F3Z|rcsb pdb:2LQC|rcsb pdb:3G43|rcsb pdb:3OXQ|rcsb pdb:5V2P|rcsb pdb:5V2Q|rcsb pdb:6C0A|rcsb pdb:6DAD|rcsb pdb:6DAE|rcsb pdb:6DAF|rcsb pdb:6U39|rcsb pdb:6U3A|rcsb pdb:6U3B|rcsb pdb:6U3D|go:"GO:0070588"(calcium ion transmembrane transport)|reactome:R-HSA-5576892|dip:DIP-29589N	ensembl:ENSG00000100151(gene)|ensembl:ENST00000356976(transcript)|ensembl:ENST00000404072(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|refseq:NP_001034672.1|refseq:NP_001034673.1|refseq:NP_036539.1|go:"GO:0015844"(monoamine transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021782"(glial cell development)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0034315"(regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0034316"(negative regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0036294"(cellular response to decreased oxygen levels)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0043113"(receptor clustering)|go:"GO:0045161"(neuronal ion channel clustering)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051015"(actin filament binding)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0098842"(postsynaptic early endosome)|go:"GO:0140090"(membrane curvature sensor activity)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR010504(Arfaptin-like)|interpro:IPR027267|interpro:IPR030798|interpro:IPR036034|interpro:IPR037959|mint:Q9NRD5|rcsb pdb:2GZV|rcsb pdb:6AR4|rcsb pdb:6BJN|rcsb pdb:6BJO|reactome:R-HSA-202733|reactome:R-HSA-416993	-	-	-	figure legend:SF1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2020/10/05	2020/12/11	rogid:dhWcWUTulWYd/nQtGorjr481/XA9606	rogid:qRx+eNG7We8Oe0SQOekqpJpn8zk9606	rigid:zEDYVUnXY1rvdeeE4ONLLCoYkJY	false	glutathione s tranferase tag:?-?|sufficient binding region:1841-2221	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q13936	uniprotkb:P12814	intact:EBI-1038838|uniprotkb:Q13917|uniprotkb:Q13918|uniprotkb:Q13919|uniprotkb:Q13920|uniprotkb:Q13921|uniprotkb:Q13922|uniprotkb:Q13923|uniprotkb:Q13924|uniprotkb:Q13925|uniprotkb:Q13926|uniprotkb:Q13927|uniprotkb:Q13928|uniprotkb:Q13929|uniprotkb:Q13930|uniprotkb:Q13932|uniprotkb:Q13933|uniprotkb:Q14743|uniprotkb:Q14744|uniprotkb:Q15877|uniprotkb:Q4VMI7|uniprotkb:Q4VMI8|uniprotkb:Q4VMI9|uniprotkb:Q6PKM7|uniprotkb:Q8N6C0|uniprotkb:Q99025|uniprotkb:Q99241|uniprotkb:Q99875|uniprotkb:B2RUT3|uniprotkb:E9PDJ0	intact:EBI-351710|uniprotkb:Q9BTN1|uniprotkb:Q1HE25|uniprotkb:B7TY16|intact:EBI-3866221|uniprotkb:B3V8S3|uniprotkb:B4DHH3|ensembl:ENSP00000193403	psi-mi:cac1c_human(display_long)|uniprotkb:CACNA1C(gene name)|psi-mi:CACNA1C(display_short)|uniprotkb:CACH2(gene name synonym)|uniprotkb:CACN2(gene name synonym)|uniprotkb:CACNL1A1(gene name synonym)|uniprotkb:CCHL1A1(gene name synonym)|uniprotkb:Voltage-gated calcium channel subunit alpha Cav1.2(gene name synonym)|uniprotkb:Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle(gene name synonym)	psi-mi:actn1_human(display_long)|uniprotkb:ACTN1(gene name)|psi-mi:ACTN1(display_short)|uniprotkb:Alpha-actinin cytoskeletal isoform(gene name synonym)|uniprotkb:Non-muscle alpha-actinin-1(gene name synonym)|uniprotkb:F-actin cross-linking protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26508347|imex:IM-28561-1083	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000710.5|refseq:NP_001123299.1|refseq:NP_001123301.1|refseq:NP_001123303.1|refseq:NP_001123304.1|refseq:NP_001123305.1|refseq:NP_001123306.1|refseq:NP_001123307.1|refseq:NP_001123314.1|refseq:NP_001123315.1|refseq:NP_001123308.1|refseq:NP_001123309.1|refseq:NP_001123310.1|refseq:NP_001123311.1|refseq:NP_001123312.1|refseq:NP_001123313.1|refseq:NP_001123316.1|refseq:NP_001123318.1|refseq:NP_001161095.1|refseq:NP_001161097.1|refseq:NP_001123302.2|refseq:NP_001161096.2|refseq:NP_955630.3|reactome:R-HSA-5576893|reactome:R-HSA-400042|reactome:R-HSA-419037|reactome:R-HSA-422356|go:"GO:0002520"(immune system development)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007507"(heart development)|go:"GO:0008331"(high voltage-gated calcium channel activity)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030425"(dendrite)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035585"(calcium-mediated signaling using extracellular calcium source)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043204"(perikaryon)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0061337"(cardiac conduction)|go:"GO:0061577"(calcium ion transmembrane transport via high voltage-gated calcium channel)|go:"GO:0070509"(calcium ion import)|go:"GO:0086002"(cardiac muscle cell action potential involved in contraction)|go:"GO:0086007"(voltage-gated calcium channel activity involved in cardiac muscle cell action potential)|go:"GO:0086012"(membrane depolarization during cardiac muscle cell action potential)|go:"GO:0086045"(membrane depolarization during AV node cell action potential)|go:"GO:0086056"(voltage-gated calcium channel activity involved in AV node cell action potential)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|go:"GO:0098912"(membrane depolarization during atrial cardiac muscle cell action potential)|go:"GO:1990454"(L-type voltage-gated calcium channel complex)|interpro:IPR002077(Voltage-dependent calcium channel, alpha-1 subunit)|interpro:IPR005446(Voltage-dependent calcium channel, L-type, alpha-1 subunit)|interpro:IPR005451(Voltage-dependent calcium channel, L-type, alpha-1C subunit)|interpro:IPR005821(Ion transport)|interpro:IPR014873(Voltage-dependent calcium channel, alpha-1 subunit, IQ domain)|interpro:IPR027359|interpro:IPR031649|interpro:IPR031688|rcsb pdb:1T0J|rcsb pdb:2BE6|rcsb pdb:2F3Y|rcsb pdb:2F3Z|rcsb pdb:2LQC|rcsb pdb:3G43|rcsb pdb:3OXQ|rcsb pdb:5V2P|rcsb pdb:5V2Q|rcsb pdb:6C0A|rcsb pdb:6DAD|rcsb pdb:6DAE|rcsb pdb:6DAF|rcsb pdb:6U39|rcsb pdb:6U3A|rcsb pdb:6U3B|rcsb pdb:6U3D|go:"GO:0070588"(calcium ion transmembrane transport)|reactome:R-HSA-5576892|dip:DIP-29589N	refseq:NP_001093.1|refseq:NP_001123477.1|refseq:NP_001123476.1|dip:DIP-33184N|ensembl:ENSG00000072110(gene)|ensembl:ENST00000193403(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005916"(fascia adherens)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0017166"(vinculin binding)|go:"GO:0030018"(Z disc)|go:"GO:0030220"(platelet formation)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031143"(pseudopodium)|go:"GO:0036344"(platelet morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0042995"(cell projection)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051271"(negative regulation of cellular component movement)|go:"GO:0051639"(actin filament network formation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099186"(structural constituent of postsynapse)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR018247|interpro:IPR036872|mint:P12814|rcsb pdb:2EYI|rcsb pdb:2EYN|rcsb pdb:2N8Y|rcsb pdb:2N8Z|reactome:R-HSA-114608|reactome:R-HSA-3000170|reactome:R-HSA-373753|reactome:R-HSA-446388|reactome:R-HSA-9013405|reactome:R-HSA-9013418|reactome:R-HSA-9035034	-	-	-	figure legend:SF1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2020/10/05	2020/12/11	rogid:dhWcWUTulWYd/nQtGorjr481/XA9606	rogid:guTURyt26f1ort4NAlYyabNc+WE9606	rigid:S6xtVDT26nTMUwNNoG5CWsXsIqU	false	glutathione s tranferase tag:?-?|sufficient binding region:1841-2221	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q96QS3	uniprotkb:P12814	intact:EBI-11107474|ensembl:ENSP00000368332	intact:EBI-351710|uniprotkb:Q9BTN1|uniprotkb:Q1HE25|uniprotkb:B7TY16|intact:EBI-3866221|uniprotkb:B3V8S3|uniprotkb:B4DHH3|ensembl:ENSP00000193403	psi-mi:arx_human(display_long)|uniprotkb:ARX(gene name)|psi-mi:ARX(display_short)|uniprotkb:Aristaless-related homeobox(gene name synonym)	psi-mi:actn1_human(display_long)|uniprotkb:ACTN1(gene name)|psi-mi:ACTN1(display_short)|uniprotkb:Alpha-actinin cytoskeletal isoform(gene name synonym)|uniprotkb:Non-muscle alpha-actinin-1(gene name synonym)|uniprotkb:F-actin cross-linking protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26508327|imex:IM-28561-1081	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_620689.1|ensembl:ENSG00000004848(gene)|ensembl:ENST00000379044(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007411"(axon guidance)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0021759"(globus pallidus development)|go:"GO:0021800"(cerebral cortex tangential migration)|go:"GO:0021831"(embryonic olfactory bulb interneuron precursor migration)|go:"GO:0021846"(cell proliferation in forebrain)|go:"GO:0021853"(cerebral cortex GABAergic interneuron migration)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0044241"(lipid digestion)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0048484"(enteric nervous system development)|go:"GO:0072148"(epithelial cell fate commitment)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR003654(Paired-like homeodomain protein, OAR)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970	refseq:NP_001093.1|refseq:NP_001123477.1|refseq:NP_001123476.1|dip:DIP-33184N|ensembl:ENSG00000072110(gene)|ensembl:ENST00000193403(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005916"(fascia adherens)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0017166"(vinculin binding)|go:"GO:0030018"(Z disc)|go:"GO:0030220"(platelet formation)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031143"(pseudopodium)|go:"GO:0036344"(platelet morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0042995"(cell projection)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051271"(negative regulation of cellular component movement)|go:"GO:0051639"(actin filament network formation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099186"(structural constituent of postsynapse)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR018247|interpro:IPR036872|mint:P12814|rcsb pdb:2EYI|rcsb pdb:2EYN|rcsb pdb:2N8Y|rcsb pdb:2N8Z|reactome:R-HSA-114608|reactome:R-HSA-3000170|reactome:R-HSA-373753|reactome:R-HSA-446388|reactome:R-HSA-9013405|reactome:R-HSA-9013418|reactome:R-HSA-9035034	-	-	-	figure legend:SF1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2020/10/05	2020/12/11	rogid:rBLZYkByOhAZEXEvFVmWxRB3oN09606	rogid:guTURyt26f1ort4NAlYyabNc+WE9606	rigid:xAGTkZWMExLvbVWIXRvT12gYBDw	false	glutathione s tranferase tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P51114	uniprotkb:Q96CW1	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-297683|ensembl:ENSP00000292807|uniprotkb:A6NE12|uniprotkb:P20172|uniprotkb:P53679|uniprotkb:D3DNT1	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:ap2m1_human(display_long)|uniprotkb:Adaptor protein complex AP-2 subunit mu(gene name synonym)|uniprotkb:AP-2 mu chain(gene name synonym)|uniprotkb:AP2M1(gene name)|psi-mi:AP2M1(display_short)|uniprotkb:CLAPM1(gene name synonym)|uniprotkb:KIAA0109(gene name synonym)|uniprotkb:Adaptin-mu2(gene name synonym)|uniprotkb:Plasma membrane adaptor AP-2 50 kDa protein(gene name synonym)|uniprotkb:HA2 50 kDa subunit(gene name synonym)|uniprotkb:Clathrin coat assembly protein AP50(gene name synonym)|uniprotkb:Clathrin coat-associated protein AP50(gene name synonym)|uniprotkb:Clathrin assembly protein complex 2 mu medium chain(gene name synonym)|uniprotkb:Adaptor-related protein complex 2 subunit mu(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26508401|imex:IM-28561-643	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	ensembl:ENSG00000161203(gene)|ensembl:ENST00000292807(transcript)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005048"(signal sequence binding)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0034622"|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0006897"(endocytosis)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0008289"(lipid binding)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030122"(AP-2 adaptor complex)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0031623"(receptor internalization)|go:"GO:0097494"(regulation of vesicle size)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|interpro:IPR001392(Clathrin adaptor, mu subunit)|interpro:IPR011012(Longin-like)|interpro:IPR018240|interpro:IPR022775|interpro:IPR028565|interpro:IPR036168|interpro:IPR043512|interpro:IPR043532|mint:Q96CW1|rcsb pdb:1H6E|rcsb pdb:6BNT|rcsb pdb:6URI|reactome:R-HSA-164939|reactome:R-HSA-167590|reactome:R-HSA-177504|reactome:R-HSA-190873|reactome:R-HSA-196025|reactome:R-HSA-2132295|reactome:R-HSA-3928665|reactome:R-HSA-416993|reactome:R-HSA-437239|reactome:R-HSA-5099900|reactome:R-HSA-5140745|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866427|reactome:R-HSA-8964038|reactome:R-HSA-9679191|reactome:R-HSA-182218|refseq:NP_001020376.1|refseq:NP_004059.2|refseq:NP_001298127.1	-	-	-	figure legend:SF1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2020/10/05	2020/12/09	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:AyJEJTqzHtIRWEnMGBzLQP3H5lA9606	rigid:EpzpV8MLQ4tGdaXLlMSiqrmGbF8	false	glutathione s tranferase tag:?-?|sufficient binding region:215-363	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P49639	uniprotkb:Q99435	intact:EBI-740785|uniprotkb:O43363|uniprotkb:B2R8U7|uniprotkb:A4D184	intact:EBI-946274|intact:EBI-2845314|uniprotkb:B7Z2U7|uniprotkb:B7Z5Q4|uniprotkb:B7Z9J5|uniprotkb:B7Z9U3|uniprotkb:Q96JS2|ensembl:ENSP00000390680|ensembl:ENSP00000394612	psi-mi:hxa1_human(display_long)|uniprotkb:Homeobox protein Hox-1F(gene name synonym)|uniprotkb:HOXA1(gene name)|psi-mi:HOXA1(display_short)|uniprotkb:HOX1F(gene name synonym)	psi-mi:nell2_human(display_long)|uniprotkb:NELL2(gene name)|psi-mi:NELL2(display_short)|uniprotkb:NRP2(gene name synonym)|uniprotkb:NEL-like protein 2(gene name synonym)|uniprotkb:Nel-related protein 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26508527|imex:IM-28561-863	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005513.1|refseq:NP_705873.2|interpro:IPR001356(Homeobox)|interpro:IPR017970|interpro:IPR020479|interpro:IPR009057(Homeodomain-like)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007634"(optokinetic behavior)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0021599"(abducens nerve formation)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048702"(embryonic neurocranium morphogenesis)|go:"GO:0048839"(inner ear development)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050795"(regulation of behavior)|go:"GO:0050890"(cognition)|go:"GO:0050905"(neuromuscular process)|go:"GO:0060840"(artery development)|go:"GO:0060876"(semicircular canal formation)|go:"GO:0090102"(cochlea development)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|reactome:R-HSA-5617472|mint:P49639	refseq:NP_001138579.1|refseq:NP_001138580.1|refseq:NP_001138581.1|refseq:NP_001138582.1|refseq:NP_006150.1|refseq:XP_011536698.1|refseq:XP_005268962.1|dip:DIP-49927N|ensembl:ENSG00000184613(gene)|ensembl:ENST00000429094(transcript)|ensembl:ENST00000452445(transcript)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0008201"(heparin binding)|go:"GO:0070050"(neuron cellular homeostasis)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR001791(Laminin G)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR018097|mint:Q99435|rcsb pdb:6POG|reactome:R-HSA-428542	-	-	-	figure legend:SF1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2020/10/05	2020/12/11	rogid:QjQVU0uonSpj5vQU0pgzXuXmW3Y9606	rogid:/NYlmX9iC3H17WXd+u97CVwOD7c9606	rigid:bQDs60l3tf3HaY8/W1CwbcoIfAs	false	glutathione s tranferase tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P51114	uniprotkb:P07437	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-350864|uniprotkb:P05218|uniprotkb:Q8WUC1|uniprotkb:Q9CY33|ensembl:ENSP00000339001|ensembl:ENSP00000373058|ensembl:ENSP00000399155|ensembl:ENSP00000400663|ensembl:ENSP00000401317|ensembl:ENSP00000406811|ensembl:ENSP00000410071|ensembl:ENSP00000410829	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:tbb5_human(display_long)|uniprotkb:TUBB(gene name)|psi-mi:TUBB(display_short)|uniprotkb:Tubulin beta-5 chain(gene name synonym)|uniprotkb:TUBB5(gene name synonym)|uniprotkb:OK/SW-cl.56(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26508517|imex:IM-28561-861	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_821133.1|refseq:NP_001280141.1|refseq:NP_001280142.1|refseq:NP_001280143.1|refseq:NP_001280144.1|refseq:NP_001280145.1|ensembl:ENSG00000183311(gene)|ensembl:ENSG00000196230(gene)|ensembl:ENSG00000224156(gene)|ensembl:ENSG00000227739(gene)|ensembl:ENSG00000229684(gene)|ensembl:ENSG00000232421(gene)|ensembl:ENSG00000232575(gene)|ensembl:ENSG00000235067(gene)|ensembl:ENST00000327892(transcript)|ensembl:ENST00000383564(transcript)|ensembl:ENST00000419792(transcript)|ensembl:ENST00000421473(transcript)|ensembl:ENST00000422650(transcript)|ensembl:ENST00000422674(transcript)|ensembl:ENST00000432462(transcript)|ensembl:ENST00000436628(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005874"(microtubule)|go:"GO:0007017"(microtubule-based process)|go:"GO:0009987"(cellular process)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0051225"(spindle assembly)|go:"GO:0051301"(cell division)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000217(Tubulin)|interpro:IPR002453(Beta tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR013838(Beta tubulin, autoregulation binding site)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:P07437|rcsb pdb:3QNZ|rcsb pdb:3QO0|rcsb pdb:5N5N|rcsb pdb:6I2I|rcsb pdb:6QUS|rcsb pdb:6QUY|rcsb pdb:6QVE|rcsb pdb:6QVJ|reactome:R-HSA-2565942|go:"GO:0050807"(regulation of synapse organization)|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-5620912|reactome:R-HSA-6798695|reactome:R-HSA-8854518|reactome:R-HSA-9679191|reactome:R-HSA-380320|dip:DIP-32772N	-	-	-	figure legend:SF1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:B6pmb1dvCroZXGd/1Zazi+s72GA9606	rigid:oP2FPoCsYb730oAb5cJsAO3pRzM	false	glutathione s tranferase tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P51114	uniprotkb:P04637	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-366083|uniprotkb:Q15086|uniprotkb:Q15087|uniprotkb:Q15088|uniprotkb:Q16535|uniprotkb:Q16807|uniprotkb:Q16808|uniprotkb:Q16809|uniprotkb:Q16810|uniprotkb:Q16811|uniprotkb:Q16848|uniprotkb:Q86UG1|uniprotkb:Q8J016|uniprotkb:Q99659|uniprotkb:Q9BTM4|uniprotkb:Q9HAQ8|uniprotkb:Q9NP68|uniprotkb:Q9NPJ2|uniprotkb:Q9NZD0|uniprotkb:Q9UBI2|uniprotkb:Q9UQ61|ensembl:ENSP00000269305|ensembl:ENSP00000391478|intact:EBI-28980681|uniprotkb:Q2XN98|uniprotkb:Q3LRW1|uniprotkb:Q3LRW2|uniprotkb:Q3LRW3|uniprotkb:Q3LRW4|uniprotkb:Q3LRW5	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:p53_human(display_long)|uniprotkb:TP53(gene name)|psi-mi:TP53(display_short)|uniprotkb:P53(gene name synonym)|uniprotkb:Tumor suppressor p53(gene name synonym)|uniprotkb:Phosphoprotein p53(gene name synonym)|uniprotkb:Antigen NY-CO-13(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26508507|imex:IM-28561-843	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_001263624.1|refseq:NP_001263625.1|ensembl:ENSG00000141510(gene)|ensembl:ENST00000269305(transcript)|ensembl:ENST00000445888(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001756"(somitogenesis)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002309"(T cell proliferation involved in immune response)|go:"GO:0002360"(T cell lineage commitment)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0031497"(chromatin assembly)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034103"(regulation of tissue remodeling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035033"(histone deacetylase regulator activity)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035690"|go:"GO:0035794"(positive regulation of mitochondrial membrane permeability)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0036310"(ATP-dependent DNA/DNA annealing activity)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0002931"(response to ischemia)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0006983"(ER overload response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007369"(gastrulation)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043504"(mitochondrial DNA repair)|go:"GO:0043516"(regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0043621"(protein self-association)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048512"(circadian behavior)|go:"GO:0048539"(bone marrow development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051097"(negative regulation of helicase activity)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062100"(positive regulation of programmed necrotic cell death)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071494"(cellular response to UV-C)|go:"GO:0072331"(signal transduction by p53 class mediator)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0072717"(cellular response to actinomycin D)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090343"(positive regulation of cell aging)|go:"GO:0090399"(replicative senescence)|go:"GO:0090403"(oxidative stress-induced premature senescence)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0097252"(oligodendrocyte apoptotic process)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0140296"(general transcription initiation factor binding)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|go:"GO:1901525"(negative regulation of mitophagy)|go:"GO:1902108"(regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1902253"(regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904024"(negative regulation of glucose catabolic process to lactate via pyruvate)|go:"GO:1905856"(negative regulation of pentose-phosphate shunt)|go:"GO:1990144"(intrinsic apoptotic signaling pathway in response to hypoxia)|go:"GO:1990248"(regulation of transcription from RNA polymerase II promoter in response to DNA damage)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000269"(regulation of fibroblast apoptotic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000772"(regulation of cellular senescence)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|go:"GO:0007569"(cell aging)|go:"GO:0008104"(protein localization)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009299"(mRNA transcription)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009651"(response to salt stress)|go:"GO:0010165"(response to X-ray)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0016032"(viral process)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031065"(positive regulation of histone deacetylation)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013872("p53 transactivation domain (TAD)")|interpro:IPR036674|interpro:IPR040926|rcsb pdb:2ATA|rcsb pdb:2B3G|rcsb pdb:2BIM|rcsb pdb:2BIN|rcsb pdb:2BIO|rcsb pdb:2BIP|rcsb pdb:2AHI|rcsb pdb:2BIQ|rcsb pdb:2F1X|rcsb pdb:2FEJ|rcsb pdb:2FOJ|rcsb pdb:2FOO|rcsb pdb:2GS0|rcsb pdb:2H1L|rcsb pdb:2H2D|rcsb pdb:2H2F|rcsb pdb:2H4F|rcsb pdb:2H4H|rcsb pdb:2H4J|rcsb pdb:2H59|rcsb pdb:2J0Z|rcsb pdb:2J10|rcsb pdb:2J11|rcsb pdb:2J1W|rcsb pdb:2J1X|rcsb pdb:2J1Y|rcsb pdb:2J1Z|rcsb pdb:2J20|rcsb pdb:2J21|rcsb pdb:2K8F|rcsb pdb:2L14|rcsb pdb:2LY4|rcsb pdb:2MEJ|rcsb pdb:2MWO|rcsb pdb:2MWP|rcsb pdb:2MWY|rcsb pdb:2MZD|rcsb pdb:2OCJ|rcsb pdb:2PCX|rcsb pdb:1A1U|rcsb pdb:1AIE|rcsb pdb:1C26|rcsb pdb:1DT7|rcsb pdb:1GZH|rcsb pdb:1H26|rcsb pdb:1HS5|rcsb pdb:1JSP|rcsb pdb:1KZY|rcsb pdb:1MA3|rcsb pdb:1OLG|rcsb pdb:1OLH|rcsb pdb:1PES|rcsb pdb:1PET|mint:P04637|rcsb pdb:1SAE|rcsb pdb:1SAF|rcsb pdb:1SAK|rcsb pdb:1SAL|rcsb pdb:1TSR|rcsb pdb:1TUP|rcsb pdb:1UOL|rcsb pdb:1XQH|rcsb pdb:1YC5|rcsb pdb:1YCQ|rcsb pdb:1YCR|rcsb pdb:1YCS|rcsb pdb:2AC0|rcsb pdb:2ADY|refseq:NP_000537.3|refseq:NP_001119584.1|refseq:NP_001119585.1|refseq:NP_001119586.1|refseq:NP_001119587.1|refseq:NP_001119588.1|refseq:NP_001119589.1|rcsb pdb:2RUK|rcsb pdb:2VUK|rcsb pdb:3Q06|rcsb pdb:2WGX|rcsb pdb:2X0U|rcsb pdb:2X0V|rcsb pdb:2X0W|rcsb pdb:2XWR|rcsb pdb:2YBG|rcsb pdb:2YDR|rcsb pdb:2Z5S|rcsb pdb:2Z5T|rcsb pdb:3SAK|rcsb pdb:3D05|rcsb pdb:3D06|rcsb pdb:3D07|rcsb pdb:3D08|rcsb pdb:3D09|rcsb pdb:3D0A|rcsb pdb:3DAB|rcsb pdb:3DAC|rcsb pdb:3IGK|rcsb pdb:3IGL|rcsb pdb:3KMD|rcsb pdb:3TG5|rcsb pdb:3KZ8|rcsb pdb:3LW1|rcsb pdb:3OQ5|rcsb pdb:3PDH|rcsb pdb:3Q01|rcsb pdb:3Q05|rcsb pdb:3TS8|rcsb pdb:3ZME|rcsb pdb:4AGM|rcsb pdb:4AGN|rcsb pdb:4AGO|rcsb pdb:4AGP|rcsb pdb:4AGQ|rcsb pdb:4BUZ|rcsb pdb:4BV2|rcsb pdb:4HFZ|rcsb pdb:4HJE|rcsb pdb:4IBQ|rcsb pdb:4IBS|rcsb pdb:4IBT|rcsb pdb:4IBU|rcsb pdb:4IBV|rcsb pdb:4IBW|rcsb pdb:4IBY|rcsb pdb:4IBZ|rcsb pdb:4IJT|rcsb pdb:4KVP|rcsb pdb:4LO9|rcsb pdb:4LOE|rcsb pdb:4LOF|rcsb pdb:4MZI|rcsb pdb:4MZR|rcsb pdb:4QO1|rcsb pdb:4RP6|rcsb pdb:4RP7|rcsb pdb:4X34|rcsb pdb:4XR8|rcsb pdb:4ZZJ|rcsb pdb:5A7B|rcsb pdb:5AB9|rcsb pdb:5ABA|rcsb pdb:4AGL|rcsb pdb:5AOI|rcsb pdb:5AOJ|rcsb pdb:5AOK|rcsb pdb:5AOL|rcsb pdb:5AOM|rcsb pdb:6XRE|rcsb pdb:7BWN|rcsb pdb:7DHY|rcsb pdb:7DHZ|rcsb pdb:7EL4|reactome:R-HSA-111448|reactome:R-HSA-139915|reactome:R-HSA-1912408|reactome:R-HSA-2559580|reactome:R-HSA-2559584|reactome:R-HSA-2559585|reactome:R-HSA-2559586|reactome:R-HSA-3232118|reactome:R-HSA-349425|reactome:R-HSA-390471|reactome:R-HSA-5620971|reactome:R-HSA-5628897|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-5693565|reactome:R-HSA-6785807|reactome:R-HSA-6796648|reactome:R-HSA-6803204|reactome:R-HSA-6803205|reactome:R-HSA-6803207|reactome:R-HSA-6803211|reactome:R-HSA-6804114|reactome:R-HSA-6804115|reactome:R-HSA-6804116|reactome:R-HSA-6804754|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804758|reactome:R-HSA-6804759|reactome:R-HSA-6804760|reactome:R-HSA-6811555|reactome:R-HSA-69473|reactome:R-HSA-69481|reactome:R-HSA-69541|reactome:R-HSA-69895|reactome:R-HSA-8852276|reactome:R-HSA-8853884|reactome:R-HSA-8941855|reactome:R-HSA-8943724|reactome:R-HSA-983231|rcsb pdb:5ECG|rcsb pdb:5G4M|rcsb pdb:5G4N|rcsb pdb:5BUA|rcsb pdb:5G4O|rcsb pdb:5HOU|rcsb pdb:5HP0|rcsb pdb:5HPD|rcsb pdb:5LAP|rcsb pdb:5LGY|rcsb pdb:5MCT|rcsb pdb:5MCU|rcsb pdb:5MCV|rcsb pdb:5MCW|rcsb pdb:5MF7|rcsb pdb:5MG7|rcsb pdb:5MHC|rcsb pdb:5MOC|rcsb pdb:5O1A|rcsb pdb:5O1B|rcsb pdb:5O1C|rcsb pdb:5O1D|rcsb pdb:5O1E|rcsb pdb:5O1F|rcsb pdb:5O1G|rcsb pdb:5O1H|rcsb pdb:5O1I|rcsb pdb:5OL0|rcsb pdb:5UN8|rcsb pdb:5XZC|rcsb pdb:6FF9|rcsb pdb:6FJ5|rcsb pdb:6GGA|rcsb pdb:6GGB|rcsb pdb:6GGC|rcsb pdb:6GGD|rcsb pdb:6GGE|rcsb pdb:6GGF|rcsb pdb:6LHD|rcsb pdb:6R5L|rcsb pdb:6RJZ|rcsb pdb:6RK8|rcsb pdb:6RKI|rcsb pdb:6RKK|rcsb pdb:6RKM|rcsb pdb:6RL3|rcsb pdb:6RL4|rcsb pdb:6RL6|rcsb pdb:6RM5|rcsb pdb:6RM7|rcsb pdb:6RWH|rcsb pdb:6RWI|rcsb pdb:6RWS|rcsb pdb:6RWU|rcsb pdb:6RX2|rcsb pdb:6RZ3|rcsb pdb:6S39|rcsb pdb:6S40|rcsb pdb:6S9Q|rcsb pdb:6SHZ|rcsb pdb:6SI0|rcsb pdb:6SI1|rcsb pdb:6SI2|rcsb pdb:6SI3|rcsb pdb:6SI4|rcsb pdb:6SIN|rcsb pdb:6SIO|rcsb pdb:6SIP|rcsb pdb:6SIQ|rcsb pdb:6SL6|rcsb pdb:6SLV|rcsb pdb:6T58|rcsb pdb:6V4F|rcsb pdb:6V4H|rcsb pdb:6VQO|rcsb pdb:6VR1|rcsb pdb:6VR5|rcsb pdb:6VRM|rcsb pdb:6VRN|rcsb pdb:6W51|rcsb pdb:6S3C|ensembl:ENSP00000269305|ensembl:ENST00000420246|ensembl:ENSP00000391127|ensembl:ENSP00000391478|ensembl:ENST00000455263|ensembl:ENSP00000398846|ensembl:ENST00000504290|ensembl:ENSP00000484409|ensembl:ENST00000504937|ensembl:ENSP00000481179|ensembl:ENST00000510385|ensembl:ENSP00000478499|ensembl:ENST00000610292|ensembl:ENSP00000478219|ensembl:ENST00000610538|ensembl:ENSP00000480868|ensembl:ENST00000619485|ensembl:ENSP00000482537|ensembl:ENST00000620739|ensembl:ENSP00000481638|ensembl:ENST00000622645|ensembl:ENSP00000482222|refseq:NP_001119590.1|refseq:NP_001263626.1|refseq:NP_001263627.1|refseq:NP_001263628.1|refseq:NP_001263689.1|refseq:NP_001263690.1|dip:DIP-368N	-	-	-	figure legend:SF1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:fGN3kSCGIpi/D6d/X5kaB0Xu8/k9606	rigid:RHYebFRLCPJTaz0kO6vRY8/5PWE	false	glutathione s tranferase tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P51114	uniprotkb:Q9UI14	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-712367|ensembl:ENSP00000222008|uniprotkb:Q7Z4Y2|uniprotkb:Q9Y3R1	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:praf1_human(display_long)|uniprotkb:PRA1 family protein 1(gene name synonym)|uniprotkb:RABAC1(gene name)|psi-mi:RABAC1(display_short)|uniprotkb:PRA1(gene name synonym)|uniprotkb:PRAF1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26508497|imex:IM-28561-1091	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_006414.2|ensembl:ENSG00000105404(gene)|ensembl:ENST00000222008(transcript)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0070064"(proline-rich region binding)|interpro:IPR004895(Prenylated rab acceptor PRA1)|mint:Q9UI14	-	-	-	figure legend:SF1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:WS2rUY7yXRbR7pqWgfUCbnEiDbg9606	rigid:Zpz9oqAmtr2KHZ5wIvsyeuxooAQ	false	glutathione s tranferase tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P51114	uniprotkb:Q86UU1	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-4289858|uniprotkb:Q4KMF8|uniprotkb:Q8TEQ2|uniprotkb:O75133|uniprotkb:B0YJ63|uniprotkb:B0YJ64|intact:EBI-28975144|ensembl:ENSP00000354498|ensembl:ENSP00000469820	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:phlb1_human(display_long)|uniprotkb:PHLDB1(gene name)|psi-mi:PHLDB1(display_short)|uniprotkb:KIAA0638(gene name synonym)|uniprotkb:LL5A(gene name synonym)|uniprotkb:Protein LL5-alpha(gene name synonym)|uniprotkb:DLNB07(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26508487|imex:IM-28561-403	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	ensembl:ENST00000356063|ensembl:ENSP00000348359|ensembl:ENSP00000354498|ensembl:ENST00000528594|ensembl:ENSP00000435520|ensembl:ENST00000530994|ensembl:ENSP00000431508|ensembl:ENSP00000469820|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR037810|mint:Q86UU1|ensembl:ENSG00000019144(gene)|ensembl:ENST00000361417(transcript)|ensembl:ENST00000600882(transcript)|go:"GO:0010470"(regulation of gastrulation)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0045180"(basal cortex)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:1904261"(positive regulation of basement membrane assembly involved in embryonic body morphogenesis)|interpro:IPR000253(Forkhead-associated)|interpro:IPR001849(Pleckstrin-like)|refseq:NP_001138230.1|refseq:NP_001138231.1|refseq:NP_055972.1	-	-	-	figure legend:SF1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:Za4UuXVuMr4gzY2kr8EadOf5hWA9606	rigid:1x5e2/hSIXxZdQpnX0LiBulI6fs	false	glutathione s tranferase tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P51114	uniprotkb:Q15233	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-350527|ensembl:ENSP00000503233|uniprotkb:O00201|uniprotkb:P30807|uniprotkb:Q12786|uniprotkb:Q9BQC5|ensembl:ENSP00000276079|ensembl:ENSP00000362947|ensembl:ENSP00000406673|ensembl:ENSP00000410299|ensembl:ENSP00000415777|ensembl:ENSP00000503031|ensembl:ENSP00000504314|ensembl:ENSP00000504351|uniprotkb:D3DVV4|uniprotkb:B7Z4C2|uniprotkb:F5GYZ3	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:nono_human(display_long)|uniprotkb:NONO(gene name)|psi-mi:NONO(display_short)|uniprotkb:NRB54(gene name synonym)|uniprotkb:54 kDa nuclear RNA- and DNA-binding protein(gene name synonym)|uniprotkb:"p54(nrb)"(gene name synonym)|uniprotkb:55 kDa nuclear protein(gene name synonym)|uniprotkb:NMT55(gene name synonym)|uniprotkb:DNA-binding p52/p100 complex, 52 kDa subunit(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26508477|imex:IM-28561-205	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_001138880.1|refseq:NP_001138881.1|refseq:NP_001138882.1|refseq:NP_031389.3|ensembl:ENSG00000147140(gene)|ensembl:ENST00000276079(transcript)|ensembl:ENST00000373841(transcript)|ensembl:ENST00000420903(transcript)|ensembl:ENST00000450092(transcript)|ensembl:ENST00000454976(transcript)|ensembl:ENST00000677274(transcript)|ensembl:ENST00000677446(transcript)|ensembl:ENST00000677612(transcript)|ensembl:ENST00000678231(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001650"(fibrillar center)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006397"(mRNA processing)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008380"(RNA splicing)|go:"GO:0016020"(membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0042382"(paraspeckles)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1903377"(negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR012975(NOPS)|interpro:IPR034552|interpro:IPR035979|mint:Q15233|rcsb pdb:3SDE|rcsb pdb:5IFM|rcsb pdb:6WMZ|rcsb pdb:7LRQ|dip:DIP-29951N	-	-	-	figure legend:SF1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:5W3ooO4h0qh3GKO+WjDrLBhihHA9606	rigid:8DVI6hNHqWMa2j22pMGuqsEH0SE	false	glutathione s tranferase tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P51114	uniprotkb:Q8WZ19	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-742916|ensembl:ENSP00000311202|ensembl:ENSP00000455785|uniprotkb:Q96P93|uniprotkb:Q96SA1|uniprotkb:A8K0R5	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:bacd1_human(display_long)|uniprotkb:Polymerase delta-interacting protein 1(gene name synonym)|uniprotkb:TNFAIP1-like protein(gene name synonym)|uniprotkb:KCTD13(gene name)|psi-mi:KCTD13(display_short)|uniprotkb:PDIP1(gene name synonym)|uniprotkb:POLDIP1(gene name synonym)|uniprotkb:FKSG86(orf name)|uniprotkb:PP6832(orf name)|uniprotkb:BACURD1(gene name synonym)|uniprotkb:BTB/POZ domain-containing protein KCTD13(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26508457|imex:IM-28561-1089	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_849194.1|ensembl:ENSG00000174943(gene)|ensembl:ENST00000308768(transcript)|ensembl:ENST00000568000(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016477"(cell migration)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051260"(protein homooligomerization)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR003131(Potassium channel, voltage dependent, Kv,  tetramerisation)|interpro:IPR011333(BTB/POZ fold)|mint:Q8WZ19|rcsb pdb:4UIJ|reactome:R-HSA-9696264|reactome:R-HSA-9696270	-	-	-	figure legend:SF1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:hAH5yJEoda0H1anmnSXWHO0o1ZM9606	rigid:8n+VqG5I155NmZjU+qH9ka6iaHo	false	glutathione s tranferase tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P51114	uniprotkb:P21333	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-350432|uniprotkb:Q8NF52|intact:EBI-1103234|ensembl:ENSP00000358866|uniprotkb:Q5HY53|uniprotkb:Q5HY55|uniprotkb:E9KL45	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:flna_human(display_long)|uniprotkb:FLNA(gene name)|psi-mi:FLNA(display_short)|uniprotkb:FLN(gene name synonym)|uniprotkb:FLN1(gene name synonym)|uniprotkb:Alpha-filamin(gene name synonym)|uniprotkb:Filamin-1(gene name synonym)|uniprotkb:Endothelial actin-binding protein(gene name synonym)|uniprotkb:Actin-binding protein 280(gene name synonym)|uniprotkb:Non-muscle filamin(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26508447|imex:IM-28561-645	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	go:"GO:0007195"(adenylate cyclase-inhibiting dopamine receptor signaling pathway)|go:"GO:1902396"(protein localization to bicellular tight junction)|refseq:NP_001104026.1|refseq:NP_001447.2|ensembl:ENSG00000196924(gene)|ensembl:ENST00000369850(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048680"(positive regulation of axon regeneration)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051015"(actin filament binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0051764"(actin crosslink formation)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090042"(tubulin deacetylation)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0097368"(establishment of Sertoli cell barrier)|go:"GO:0097440"(apical dendrite)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901381"(positive regulation of potassium ion transmembrane transport)|go:"GO:0046332"(SMAD binding)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016479"(negative regulation of transcription by RNA polymerase I)|go:"GO:0019900"(kinase binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0021943"(formation of radial glial scaffolds)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030018"(Z disc)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031523"(Myb complex)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031852"(mu-type opioid receptor binding)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0032432"(actin filament bundle)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034988"(Fc-gamma receptor I complex binding)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043113"(receptor clustering)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045296"(cadherin binding)|reactome:R-HSA-114608|reactome:R-HSA-430116|reactome:R-HSA-446353|reactome:R-HSA-5627123|reactome:R-HSA-8983711|rcsb pdb:6EW1|go:"GO:1905031"(regulation of membrane repolarization during cardiac muscle cell action potential)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2001046"(positive regulation of integrin-mediated signaling pathway)|go:"GO:2001224"(positive regulation of neuron migration)|interpro:IPR001298(Filamin/ABP280 repeat)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR036872|interpro:IPR044801|mint:P21333|rcsb pdb:2AAV|rcsb pdb:2BP3|rcsb pdb:2BRQ|rcsb pdb:2J3S|rcsb pdb:2JF1|rcsb pdb:2K3T|rcsb pdb:2K7P|rcsb pdb:2K7Q|rcsb pdb:2MTP|rcsb pdb:2W0P|rcsb pdb:2WFN|rcsb pdb:3CNK|rcsb pdb:3HOC|rcsb pdb:3HOP|rcsb pdb:3HOR|rcsb pdb:3ISW|rcsb pdb:3RGH|rcsb pdb:4M9P|rcsb pdb:4P3W|rcsb pdb:5XR1|rcsb pdb:6D8C|go:"GO:1905000"(regulation of membrane repolarization during atrial cardiac muscle cell action potential)|dip:DIP-1136N	-	-	-	figure legend:SF1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:ZxGK5OSMy8cNsyt7Ax2KXb8bn9M9606	rigid:4Js/Y6p3ViF+6lq6aX6PnlAddrM	false	glutathione s tranferase tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P51114	uniprotkb:Q674X7	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-949239|uniprotkb:B0QYQ0|uniprotkb:B1AK78|uniprotkb:Q5TGF1|uniprotkb:Q674X6|uniprotkb:Q6ZUD1|uniprotkb:Q8IYN7|uniprotkb:Q8N409|uniprotkb:Q9UIL2|uniprotkb:Q674X4|ensembl:ENSP00000365198|uniprotkb:Q9UPX4|uniprotkb:B1AJZ1	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:kazrn_human(display_long)|uniprotkb:KIAA1026(gene name synonym)|uniprotkb:HRIHFB2003(orf name)|uniprotkb:KAZN(gene name)|psi-mi:KAZN(display_short)|uniprotkb:KAZ(gene name synonym)|uniprotkb:C1orf196(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26508467|imex:IM-28561-841	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	ensembl:ENSG00000189337(gene)|ensembl:ENST00000376030(transcript)|go:"GO:0001533"(cornified envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0016607"(nuclear speck)|go:"GO:0030057"(desmosome)|go:"GO:0031424"(keratinization)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR037613|interpro:IPR037614|interpro:IPR037615|interpro:IPR037616|mint:Q674X7|reactome:R-HSA-6809371|refseq:NP_001017999.1|refseq:NP_001018000.1|refseq:NP_001018001.1|refseq:NP_056024.1|refseq:NP_963922.2|refseq:XP_016856260.1	-	-	-	figure legend:SF1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:Ai9moSFrBZMcWm4XWkk/vGzD5yE9606	rigid:Mm9ePCPH1uv6gB0NUFj2L/3A6gQ	false	glutathione s tranferase tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P51114	uniprotkb:Q9P209	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-739498|uniprotkb:Q9BV03|uniprotkb:Q9BWM3|uniprotkb:Q9NVR4|uniprotkb:B4DR26|ensembl:ENSP00000264935	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:cep72_human(display_long)|uniprotkb:CEP72(gene name)|psi-mi:CEP72(display_short)|uniprotkb:KIAA1519(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26508425|imex:IM-28561-1323	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_060610.2|ensembl:ENSG00000112877(gene)|ensembl:ENST00000264935(transcript)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007051"(spindle organization)|go:"GO:0007099"(centriole replication)|go:"GO:0033566"(gamma-tubulin complex localization)|go:"GO:0034451"(centriolar satellite)|go:"GO:1904779"(regulation of protein localization to centrosome)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR003603(U2A'/phosphoprotein 32 family A, C-terminal)|interpro:IPR032675|interpro:IPR040146|mint:Q9P209|reactome:R-HSA-2565942|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-8854518|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|refseq:XP_011512365.1|dip:DIP-54272N	-	-	-	figure legend:SF1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:c00WdgE2iudiQUz3kXNZL5d0nuQ9606	rigid:+oiTd/UdyNdKbtfOC+Qt9NYyqrk	false	glutathione s tranferase tag:?-?|sufficient binding region:215-363	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P51114	uniprotkb:Q9Y232	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-1387386|uniprotkb:Q0VDG7|uniprotkb:Q32NC5|uniprotkb:Q5VX99|uniprotkb:Q6P7T5|uniprotkb:Q9BWZ2|uniprotkb:Q9Y424|uniprotkb:A8K6D6|uniprotkb:B4DLG4|ensembl:ENSP00000330512	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:cdyl_human(display_long)|uniprotkb:Crotonyl-CoA hydratase(gene name synonym)|uniprotkb:CDYL(gene name)|psi-mi:CDYL(display_short)|uniprotkb:CDYL1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26508413|imex:IM-28561-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_001137442.1|refseq:NP_001137443.1|refseq:NP_004815.3|interpro:IPR000953(Chromo domain)|interpro:IPR001753(Crotonase, core)|interpro:IPR014748(Crontonase, C-terminal)|interpro:IPR016197(Chromo domain-like)|interpro:IPR023779|interpro:IPR023780|interpro:IPR029045|mint:Q9Y232|ensembl:ENSG00000153046(gene)|ensembl:ENST00000328908(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007286"(spermatid development)|go:"GO:0016607"(nuclear speck)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0035064"(methylated histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0060816"(random inactivation of X chromosome)|go:"GO:0120092"(crotonyl-CoA hydratase activity)|go:"GO:0120094"(negative regulation of peptidyl-lysine crotonylation)|rcsb pdb:2DNT|rcsb pdb:2GTR	-	-	-	figure legend:SF1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:np0RERcg3R8KbgTKXhy50/ytvXg9606	rigid:J40r928H7w89sNKmerHTPVgQ81g	false	glutathione s tranferase tag:?-?|sufficient binding region:215-363	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P51114	uniprotkb:Q6AI12	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-2838246|uniprotkb:Q96E32|ensembl:ENSP00000285243	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:anr40_human(display_long)|uniprotkb:ANKRD40(gene name)|psi-mi:ANKRD40(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26508391|imex:IM-28561-1085	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_443087.1|ensembl:ENSG00000154945(gene)|ensembl:ENST00000285243(transcript)|interpro:IPR002110(Ankyrin)|interpro:IPR036770|interpro:IPR039195|mint:Q6AI12	-	-	-	figure legend:SF1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:N90IlLrtlIyntctaIJLemc16yqI9606	rigid:xkray5XLRzA2Pg8P5IDZcsJWbRY	false	glutathione s tranferase tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P51114	uniprotkb:O00423	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-751327|uniprotkb:Q86U15|uniprotkb:Q8N536|uniprotkb:Q8N5C4|uniprotkb:Q8WWL6|ensembl:ENSP00000262233	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:emal1_human(display_long)|uniprotkb:EML1(gene name)|psi-mi:EML1(display_short)|uniprotkb:EMAP1(gene name synonym)|uniprotkb:EMAPL(gene name synonym)|uniprotkb:EMAPL1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26508437|imex:IM-28561-1087	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_001008707.1|refseq:NP_004425.2|ensembl:ENSG00000066629(gene)|ensembl:ENST00000262233(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0007420"(brain development)|go:"GO:0008017"(microtubule binding)|go:"GO:0015631"(tubulin binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:1990023"(mitotic spindle midzone)|interpro:IPR001680(WD40 repeat)|interpro:IPR005108(HELP)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|mint:O00423|rcsb pdb:4CI8	-	-	-	figure legend:SF1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:hfGdCoFa3Miii6W/ozQuZ2cFiHs9606	rigid:ZFEkXm6LZKILLXJex1ZqwAFPvGk	false	glutathione s tranferase tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9UIS9	uniprotkb:Q99435	intact:EBI-867196|uniprotkb:K7ELI2|uniprotkb:Q9UNZ9|uniprotkb:K7EQZ4|uniprotkb:K7ESN0|uniprotkb:A4UTZ0|uniprotkb:O15248|uniprotkb:O95241|uniprotkb:Q7Z7B5|uniprotkb:Q8N4W4|uniprotkb:Q9UNZ6|uniprotkb:Q9UNZ7|uniprotkb:Q9UNZ8|uniprotkb:B4DXJ5|uniprotkb:E9PEC5|intact:EBI-10977266|ensembl:ENSP00000269468|ensembl:ENSP00000372407|ensembl:ENSP00000467017	intact:EBI-946274|intact:EBI-2845314|uniprotkb:B7Z2U7|uniprotkb:B7Z5Q4|uniprotkb:B7Z9J5|uniprotkb:B7Z9U3|uniprotkb:Q96JS2|ensembl:ENSP00000390680|ensembl:ENSP00000394612	psi-mi:mbd1_human(display_long)|uniprotkb:CXXC3(gene name synonym)|uniprotkb:Methyl-CpG-binding protein MBD1(gene name synonym)|uniprotkb:Protein containing methyl-CpG-binding domain 1(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 3(gene name synonym)|uniprotkb:MBD1(gene name)|psi-mi:MBD1(display_short)|uniprotkb:PCM1(gene name synonym)	psi-mi:nell2_human(display_long)|uniprotkb:NELL2(gene name)|psi-mi:NELL2(display_short)|uniprotkb:NRP2(gene name synonym)|uniprotkb:NEL-like protein 2(gene name synonym)|uniprotkb:Nel-related protein 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26508537|imex:IM-28561-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001191065.1|refseq:NP_001191068.1|refseq:NP_001191071.1|refseq:NP_001191072.1|refseq:NP_001191080.1|refseq:NP_002375.1|refseq:NP_056669.2|refseq:NP_056670.2|refseq:NP_056671.2|refseq:NP_056723.2|refseq:XP_011524295.1|refseq:XP_016881249.1|refseq:XP_016881259.1|refseq:XP_016881260.1|refseq:XP_016881265.1|refseq:XP_011524296.1|refseq:XP_011524308.1|refseq:NP_001191066.1|refseq:NP_001191067.1|refseq:NP_001191069.1|refseq:NP_001191070.1|refseq:XP_005258328.1|ensembl:ENSG00000141644(gene)|ensembl:ENST00000269468(transcript)|ensembl:ENST00000382948(transcript)|ensembl:ENST00000591416(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0010385"(double-stranded methylated DNA binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032355"(response to estradiol)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR016177(DNA-binding, integrase-type)|mint:Q9UIS9|rcsb pdb:1D9N|rcsb pdb:1IG4|rcsb pdb:4D4W|rcsb pdb:5W9Q|rcsb pdb:6D1T|reactome:R-HSA-3899300	refseq:NP_001138579.1|refseq:NP_001138580.1|refseq:NP_001138581.1|refseq:NP_001138582.1|refseq:NP_006150.1|refseq:XP_011536698.1|refseq:XP_005268962.1|dip:DIP-49927N|ensembl:ENSG00000184613(gene)|ensembl:ENST00000429094(transcript)|ensembl:ENST00000452445(transcript)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0008201"(heparin binding)|go:"GO:0070050"(neuron cellular homeostasis)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR001791(Laminin G)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR018097|mint:Q99435|rcsb pdb:6POG|reactome:R-HSA-428542	-	-	-	figure legend:SF1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2020/10/05	2020/12/11	rogid:I6StIYNuO8jT6ZR1YxoZnzDrP/I9606	rogid:/NYlmX9iC3H17WXd+u97CVwOD7c9606	rigid:dtW9ghODJl1SV1lMlKJh7oVawpw	false	glutathione s tranferase tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9UBB5	uniprotkb:Q16637	intact:EBI-923391|uniprotkb:Q9UIS8|uniprotkb:O95242|ensembl:ENSP00000256429	intact:EBI-395421|uniprotkb:Q13119|uniprotkb:Q549U5|uniprotkb:Q96J51|ensembl:ENSP00000305857|uniprotkb:A8K0V4|ensembl:ENSP00000370083|ensembl:ENSP00000370117|ensembl:ENSP00000370119|ensembl:ENSP00000479920|ensembl:ENSP00000482966|ensembl:ENSP00000483515|ensembl:ENSP00000483819|ensembl:ENSP00000487206|ensembl:ENSP00000487421	psi-mi:mbd2_human(display_long)|uniprotkb:MBD2(gene name)|psi-mi:MBD2(display_short)|uniprotkb:Methyl-CpG-binding protein MBD2(gene name synonym)|uniprotkb:Demethylase(gene name synonym)	psi-mi:smn_human(display_long)|uniprotkb:SMN1(gene name)|psi-mi:SMN1(display_short)|uniprotkb:SMN(gene name synonym)|uniprotkb:SMNT(gene name synonym)|uniprotkb:SMN2(gene name)|psi-mi:SMN2(display_short)|uniprotkb:SMNC(gene name synonym)|uniprotkb:Component of gems 1(gene name synonym)|uniprotkb:Gemin-1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26508547|imex:IM-28561-405	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003918.1|refseq:NP_056647.1|ensembl:ENSG00000134046(gene)|ensembl:ENST00000256429(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003696"(satellite DNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006346"(DNA methylation-dependent heterochromatin assembly)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032355"(response to estradiol)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034622"|go:"GO:0035197"(siRNA binding)|go:"GO:0035563"(positive regulation of chromatin binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042711"(maternal behavior)|go:"GO:0043044"|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048568"(embryonic organ development)|go:"GO:0070742"(C2H2 zinc finger domain binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR016177(DNA-binding, integrase-type)|interpro:IPR025884|interpro:IPR032343|mint:Q9UBB5|rcsb pdb:2L2L|rcsb pdb:6C1A|rcsb pdb:6C1T|rcsb pdb:6C1U|rcsb pdb:6C1V|rcsb pdb:6C2F|rcsb pdb:6CNP|rcsb pdb:6CNQ|rcsb pdb:7AO8|rcsb pdb:7AO9|rcsb pdb:7AOA|reactome:R-HSA-427413|reactome:R-HSA-73728	refseq:NP_000335.1|refseq:NP_059107.1|refseq:NP_075012.1|refseq:NP_075013.1|refseq:NP_075014.1|refseq:NP_075015.1|ensembl:ENSG00000172062(gene)|ensembl:ENSG00000205571(gene)|ensembl:ENSG00000273772(gene)|ensembl:ENSG00000275349(gene)|ensembl:ENSG00000277773(gene)|ensembl:ENST00000351205(transcript)|ensembl:ENST00000380707(transcript)|ensembl:ENST00000380741(transcript)|ensembl:ENST00000380743(transcript)|ensembl:ENST00000614610(transcript)|ensembl:ENST00000618251(transcript)|ensembl:ENST00000618661(transcript)|ensembl:ENST00000622739(transcript)|ensembl:ENST00000627341(transcript)|ensembl:ENST00000629122(transcript)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006353"(DNA-templated transcription, termination)|go:"GO:0007399"(nervous system development)|go:"GO:0015030"(Cajal body)|go:"GO:0016604"(nuclear body)|go:"GO:0030018"(Z disc)|go:"GO:0030424"(axon)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0097504"(Gemini of coiled bodies)|interpro:IPR002999(Tudor)|interpro:IPR010304(Survival motor neuron)|mint:Q16637|rcsb pdb:1G5V|rcsb pdb:1MHN|rcsb pdb:2LEH|rcsb pdb:4A4E|rcsb pdb:4A4G|rcsb pdb:4GLI|rcsb pdb:4QQ6|rcsb pdb:5XJL|go:"GO:0034719"(SMN-Sm protein complex)|rcsb pdb:5XJQ|rcsb pdb:5XJR|rcsb pdb:5XJS|rcsb pdb:5XJT|rcsb pdb:5XJU|reactome:R-HSA-191859|go:"GO:0032797"(SMN complex)|refseq:NP_001284644.1|ensembl:ENSP00000305857|ensembl:ENSP00000370083|ensembl:ENSP00000370117|ensembl:ENST00000380742|ensembl:ENSP00000370118|ensembl:ENSP00000370119|ensembl:ENST00000503079|ensembl:ENSP00000428128|ensembl:ENST00000506163|ensembl:ENSP00000424926|ensembl:ENST00000611442|ensembl:ENSP00000483768|ensembl:ENST00000614240|ensembl:ENSP00000479279|ensembl:ENSP00000479920|ensembl:ENST00000614773|ensembl:ENSP00000481427|ensembl:ENSP00000483515|ensembl:ENSP00000483819|ensembl:ENST00000622158|ensembl:ENSP00000480906|ensembl:ENSP00000482966|ensembl:ENST00000624634|ensembl:ENSP00000485595|ensembl:ENST00000626847|ensembl:ENSP00000486152|ensembl:ENSP00000487421|ensembl:ENST00000628353|ensembl:ENSP00000487029|ensembl:ENST00000628642|ensembl:ENSP00000487015|ensembl:ENSP00000487206|refseq:XP_016865275.1|dip:DIP-31309N	-	-	-	figure legend:SF1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2020/10/05	2020/12/11	rogid:8DO+M6oIpbSfTFPVLADdXaaqzEU9606	rogid:QGivm7E8suciCWXO4l0zCUzCl2g9606	rigid:04GsmAV8xbkumHu55Ptl32niTb8	false	glutathione s tranferase tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q7Z417	uniprotkb:Q99435	intact:EBI-1210753|intact:EBI-10172018|uniprotkb:A1L3A7|uniprotkb:Q9P2M5|uniprotkb:A1L3A6|ensembl:ENSP00000225388	intact:EBI-946274|intact:EBI-2845314|uniprotkb:B7Z2U7|uniprotkb:B7Z5Q4|uniprotkb:B7Z9J5|uniprotkb:B7Z9U3|uniprotkb:Q96JS2|ensembl:ENSP00000390680|ensembl:ENSP00000394612	psi-mi:nufp2_human(display_long)|uniprotkb:NUFIP2(gene name)|psi-mi:NUFIP2(display_short)|uniprotkb:KIAA1321(gene name synonym)|uniprotkb:PIG1(orf name)|uniprotkb:FMRP-interacting protein 2(gene name synonym)|uniprotkb:82 kDa FMRP-interacting protein(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 1 protein(gene name synonym)	psi-mi:nell2_human(display_long)|uniprotkb:NELL2(gene name)|psi-mi:NELL2(display_short)|uniprotkb:NRP2(gene name synonym)|uniprotkb:NEL-like protein 2(gene name synonym)|uniprotkb:Nel-related protein 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26508557|imex:IM-28561-1093	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_065823.1|dip:DIP-29023N|ensembl:ENSG00000108256(gene)|ensembl:ENST00000225388(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0042788"(polysomal ribosome)|interpro:IPR032747|mint:Q7Z417	refseq:NP_001138579.1|refseq:NP_001138580.1|refseq:NP_001138581.1|refseq:NP_001138582.1|refseq:NP_006150.1|refseq:XP_011536698.1|refseq:XP_005268962.1|dip:DIP-49927N|ensembl:ENSG00000184613(gene)|ensembl:ENST00000429094(transcript)|ensembl:ENST00000452445(transcript)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0008201"(heparin binding)|go:"GO:0070050"(neuron cellular homeostasis)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR001791(Laminin G)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR018097|mint:Q99435|rcsb pdb:6POG|reactome:R-HSA-428542	-	-	-	figure legend:SF1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2020/10/05	2020/12/11	rogid:zdbkRisveP+8g70umfbEPHTnAgk9606	rogid:/NYlmX9iC3H17WXd+u97CVwOD7c9606	rigid:SI6/WtmUISWMItydzdBz+wSeAhU	false	glutathione s tranferase tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q7Z417	uniprotkb:O15162	intact:EBI-1210753|intact:EBI-10172018|uniprotkb:A1L3A7|uniprotkb:Q9P2M5|uniprotkb:A1L3A6|ensembl:ENSP00000225388	intact:EBI-740019|ensembl:ENSP00000345494|uniprotkb:B2R8H8|uniprotkb:B4DTE8	psi-mi:nufp2_human(display_long)|uniprotkb:NUFIP2(gene name)|psi-mi:NUFIP2(display_short)|uniprotkb:KIAA1321(gene name synonym)|uniprotkb:PIG1(orf name)|uniprotkb:FMRP-interacting protein 2(gene name synonym)|uniprotkb:82 kDa FMRP-interacting protein(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 1 protein(gene name synonym)	psi-mi:pls1_human(display_long)|uniprotkb:PLSCR1(gene name)|psi-mi:PLSCR1(display_short)|uniprotkb:"Ca(2+)-dependent phospholipid scramblase 1"(gene name synonym)|uniprotkb:Erythrocyte phospholipid scramblase(gene name synonym)|uniprotkb:MmTRA1b(gene name synonym)|uniprotkb:"Mg(2+)-dependent nuclease"(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26508567|imex:IM-28561-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_065823.1|dip:DIP-29023N|ensembl:ENSG00000108256(gene)|ensembl:ENST00000225388(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0042788"(polysomal ribosome)|interpro:IPR032747|mint:Q7Z417	ensembl:ENSG00000188313(gene)|ensembl:ENST00000342435(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001618"(virus receptor activity)|go:"GO:0003677"(DNA binding)|go:"GO:0004518"(nuclease activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006659"(phosphatidylserine biosynthetic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006953"(acute-phase response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010288"(response to lead ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0017121"(plasma membrane phospholipid scrambling)|go:"GO:0017124"(SH3 domain binding)|ensembl:ENSP00000345494|ensembl:ENST00000448787|ensembl:ENSP00000411675|refseq:NP_066928.1|go:"GO:0017128"(phospholipid scramblase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030168"(platelet activation)|go:"GO:0032791"(lead ion binding)|go:"GO:0033003"(regulation of mast cell activation)|go:"GO:0035456"(response to interferon-beta)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045340"(mercury ion binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0051607"(defense response to virus)|go:"GO:0060368"(regulation of Fc receptor mediated stimulatory signaling pathway)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070782"(phosphatidylserine exposure on apoptotic cell surface)|go:"GO:1905820"(positive regulation of chromosome separation)|go:"GO:2000373"("positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity")|interpro:IPR005552(Scramblase)|mint:O15162|rcsb pdb:1Y2A|refseq:XP_011511209.1|refseq:XP_011511206.1|refseq:XP_005247595.1|refseq:XP_011511208.1|refseq:XP_016862118.1	-	-	-	figure legend:SF1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2020/10/05	2020/12/11	rogid:zdbkRisveP+8g70umfbEPHTnAgk9606	rogid:XudfvUkrZbB28t9tpFkokgnDFGc9606	rigid:h4Fz3CauEiXBzOOkZUnpIVjTW4M	false	glutathione s tranferase tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P60484	uniprotkb:Q9P0U4	intact:EBI-696162|uniprotkb:O00633|uniprotkb:O02679|uniprotkb:Q6ICT7|uniprotkb:B2R904|uniprotkb:F2YHV0|ensembl:ENSP00000361021	intact:EBI-949911|ensembl:ENSP00000285106|uniprotkb:Q8N2W4|uniprotkb:Q96BC8|uniprotkb:Q9P2V7|uniprotkb:B2RC03	psi-mi:pten_human(display_long)|uniprotkb:Phosphatase and tensin homolog(gene name synonym)|uniprotkb:Mutated in multiple advanced cancers 1(gene name synonym)|uniprotkb:PTEN(gene name)|psi-mi:PTEN(display_short)|uniprotkb:MMAC1(gene name synonym)|uniprotkb:TEP1(gene name synonym)	psi-mi:cxxc1_human(display_long)|uniprotkb:CFP1(gene name synonym)|uniprotkb:PHD finger and CXXC domain-containing protein 1(gene name synonym)|uniprotkb:CXXC1(gene name)|psi-mi:CXXC1(display_short)|uniprotkb:CGBP(gene name synonym)|uniprotkb:PCCX1(gene name synonym)|uniprotkb:PHF18(gene name synonym)|uniprotkb:CpG-binding protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26508577|imex:IM-28561-407	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000305.3|refseq:NP_001291646.2|refseq:NP_001291647.1|dip:DIP-35019N|ensembl:ENSG00000171862(gene)|ensembl:ENST00000371953(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002902"(regulation of B cell apoptotic process)|go:"GO:0004438"(phosphatidylinositol-3-phosphatase activity)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007270"(neuron-neuron synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007417"(central nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0007611"(learning or memory)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0009749"(response to glucose)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016314"(phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030534"(adult behavior)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0032286"(central nervous system myelin maintenance)|go:"GO:0032355"(response to estradiol)|go:"GO:0032535"(regulation of cellular component size)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033032"(regulation of myeloid cell apoptotic process)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0033198"(response to ATP)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035749"(myelin sheath adaxonal region)|go:"GO:0042493"|go:"GO:0042711"(maternal behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0046855"(inositol phosphate dephosphorylation)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048681"(negative regulation of axon regeneration)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051548"(negative regulation of keratinocyte migration)|go:"GO:0051717"(inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity)|go:"GO:0051800"(phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060024"(rhythmic synaptic transmission)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060074"(synapse maturation)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061002"(negative regulation of dendritic spine morphogenesis)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071257"(cellular response to electrical stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090071"(negative regulation of ribosome biogenesis)|go:"GO:0090344"(negative regulation of cell aging)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097105"(presynaptic membrane assembly)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1902807"(negative regulation of cell cycle G1/S phase transition)|go:"GO:1903690"(negative regulation of wound healing, spreading of epidermal cells)|go:"GO:1903984"(positive regulation of TRAIL-activated apoptotic signaling pathway)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000808"(negative regulation of synaptic vesicle clustering)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR014020(C2 tensin-type)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR017361(Bifunctional phosphatidylinositol trisphosphate phosphatase/dual-specificity phosphatase PTEN)|interpro:IPR029021|interpro:IPR029023|interpro:IPR035892|mint:P60484|rcsb pdb:1D5R|rcsb pdb:2KYL|rcsb pdb:4O1V|rcsb pdb:5BUG|rcsb pdb:5BZX|rcsb pdb:5BZZ|reactome:R-HSA-1660499|reactome:R-HSA-1855204|reactome:R-HSA-199418|reactome:R-HSA-202424|reactome:R-HSA-5628897|reactome:R-HSA-5674404|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-8943723|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-8986944	ensembl:ENSG00000154832(gene)|ensembl:ENST00000285106(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048188"(Set1C/COMPASS complex)|go:"GO:0051568"(histone H3-K4 methylation)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|reactome:R-HSA-381038|interpro:IPR022056|interpro:IPR037869|mint:Q9P0U4|rcsb pdb:3QMB|rcsb pdb:3QMC|rcsb pdb:3QMD|rcsb pdb:3QMG|rcsb pdb:3QMH|rcsb pdb:3QMI|refseq:NP_001095124.1|refseq:NP_055408.2|refseq:XP_011524242.1|refseq:XP_016881207.1|dip:DIP-50001N	-	-	-	figure legend:SF1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2020/10/05	2020/12/11	rogid:/cPQox/hRcR/ED//46U5w4lcsyc9606	rogid:nWwPX7OlafdCMD8Qg+hETjNkKgY9606	rigid:ozH+ANA9C3RuPdN2YBkR9BqvAso	false	glutathione s tranferase tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P60484	uniprotkb:Q9NRD5	intact:EBI-696162|uniprotkb:O00633|uniprotkb:O02679|uniprotkb:Q6ICT7|uniprotkb:B2R904|uniprotkb:F2YHV0|ensembl:ENSP00000361021	intact:EBI-79165|uniprotkb:O95906|ensembl:ENSP00000349465|ensembl:ENSP00000385205|intact:EBI-2622151|uniprotkb:B3KS52	psi-mi:pten_human(display_long)|uniprotkb:Phosphatase and tensin homolog(gene name synonym)|uniprotkb:Mutated in multiple advanced cancers 1(gene name synonym)|uniprotkb:PTEN(gene name)|psi-mi:PTEN(display_short)|uniprotkb:MMAC1(gene name synonym)|uniprotkb:TEP1(gene name synonym)	psi-mi:pick1_human(display_long)|uniprotkb:PICK1(gene name)|psi-mi:PICK1(display_short)|uniprotkb:PRKCABP(gene name synonym)|uniprotkb:Protein kinase C-alpha-binding protein(gene name synonym)|uniprotkb:Protein interacting with C kinase 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26508587|imex:IM-28561-865	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000305.3|refseq:NP_001291646.2|refseq:NP_001291647.1|dip:DIP-35019N|ensembl:ENSG00000171862(gene)|ensembl:ENST00000371953(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002902"(regulation of B cell apoptotic process)|go:"GO:0004438"(phosphatidylinositol-3-phosphatase activity)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007270"(neuron-neuron synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007417"(central nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0007611"(learning or memory)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0009749"(response to glucose)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016314"(phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030534"(adult behavior)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0032286"(central nervous system myelin maintenance)|go:"GO:0032355"(response to estradiol)|go:"GO:0032535"(regulation of cellular component size)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033032"(regulation of myeloid cell apoptotic process)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0033198"(response to ATP)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035749"(myelin sheath adaxonal region)|go:"GO:0042493"|go:"GO:0042711"(maternal behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0046855"(inositol phosphate dephosphorylation)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048681"(negative regulation of axon regeneration)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051548"(negative regulation of keratinocyte migration)|go:"GO:0051717"(inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity)|go:"GO:0051800"(phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060024"(rhythmic synaptic transmission)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060074"(synapse maturation)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061002"(negative regulation of dendritic spine morphogenesis)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071257"(cellular response to electrical stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090071"(negative regulation of ribosome biogenesis)|go:"GO:0090344"(negative regulation of cell aging)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097105"(presynaptic membrane assembly)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1902807"(negative regulation of cell cycle G1/S phase transition)|go:"GO:1903690"(negative regulation of wound healing, spreading of epidermal cells)|go:"GO:1903984"(positive regulation of TRAIL-activated apoptotic signaling pathway)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000808"(negative regulation of synaptic vesicle clustering)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR014020(C2 tensin-type)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR017361(Bifunctional phosphatidylinositol trisphosphate phosphatase/dual-specificity phosphatase PTEN)|interpro:IPR029021|interpro:IPR029023|interpro:IPR035892|mint:P60484|rcsb pdb:1D5R|rcsb pdb:2KYL|rcsb pdb:4O1V|rcsb pdb:5BUG|rcsb pdb:5BZX|rcsb pdb:5BZZ|reactome:R-HSA-1660499|reactome:R-HSA-1855204|reactome:R-HSA-199418|reactome:R-HSA-202424|reactome:R-HSA-5628897|reactome:R-HSA-5674404|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-8943723|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-8986944	ensembl:ENSG00000100151(gene)|ensembl:ENST00000356976(transcript)|ensembl:ENST00000404072(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|refseq:NP_001034672.1|refseq:NP_001034673.1|refseq:NP_036539.1|go:"GO:0015844"(monoamine transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021782"(glial cell development)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0034315"(regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0034316"(negative regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0036294"(cellular response to decreased oxygen levels)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0043113"(receptor clustering)|go:"GO:0045161"(neuronal ion channel clustering)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051015"(actin filament binding)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0098842"(postsynaptic early endosome)|go:"GO:0140090"(membrane curvature sensor activity)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR010504(Arfaptin-like)|interpro:IPR027267|interpro:IPR030798|interpro:IPR036034|interpro:IPR037959|mint:Q9NRD5|rcsb pdb:2GZV|rcsb pdb:6AR4|rcsb pdb:6BJN|rcsb pdb:6BJO|reactome:R-HSA-202733|reactome:R-HSA-416993	-	-	-	figure legend:SF1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2020/10/05	2020/12/11	rogid:/cPQox/hRcR/ED//46U5w4lcsyc9606	rogid:qRx+eNG7We8Oe0SQOekqpJpn8zk9606	rigid:eIpCQZ+eXWhXeTG5faLAZoQ9HdE	false	glutathione s tranferase tag:?-?|sufficient binding region:305-403	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9BYB0	uniprotkb:P12814	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-351710|uniprotkb:Q9BTN1|uniprotkb:Q1HE25|uniprotkb:B7TY16|intact:EBI-3866221|uniprotkb:B3V8S3|uniprotkb:B4DHH3|ensembl:ENSP00000193403	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:actn1_human(display_long)|uniprotkb:ACTN1(gene name)|psi-mi:ACTN1(display_short)|uniprotkb:Alpha-actinin cytoskeletal isoform(gene name synonym)|uniprotkb:Non-muscle alpha-actinin-1(gene name synonym)|uniprotkb:F-actin cross-linking protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26508599|imex:IM-28561-1095	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_001093.1|refseq:NP_001123477.1|refseq:NP_001123476.1|dip:DIP-33184N|ensembl:ENSG00000072110(gene)|ensembl:ENST00000193403(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005916"(fascia adherens)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0017166"(vinculin binding)|go:"GO:0030018"(Z disc)|go:"GO:0030220"(platelet formation)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031143"(pseudopodium)|go:"GO:0036344"(platelet morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0042995"(cell projection)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051271"(negative regulation of cellular component movement)|go:"GO:0051639"(actin filament network formation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099186"(structural constituent of postsynapse)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR018247|interpro:IPR036872|mint:P12814|rcsb pdb:2EYI|rcsb pdb:2EYN|rcsb pdb:2N8Y|rcsb pdb:2N8Z|reactome:R-HSA-114608|reactome:R-HSA-3000170|reactome:R-HSA-373753|reactome:R-HSA-446388|reactome:R-HSA-9013405|reactome:R-HSA-9013418|reactome:R-HSA-9035034	-	-	-	figure legend:SF1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:guTURyt26f1ort4NAlYyabNc+WE9606	rigid:OL2TG7jx2hHyhhVBBiahfBrX0KQ	false	glutathione s tranferase tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9BYB0	uniprotkb:Q14155	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-717515|uniprotkb:B1ALK6|uniprotkb:B1ALK8|uniprotkb:Q3LIA4|uniprotkb:Q5W9H0|uniprotkb:Q6P9G3|uniprotkb:Q6PII2|uniprotkb:Q86W63|uniprotkb:Q8N3M1|ensembl:ENSP00000364893	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:arhg7_human(display_long)|uniprotkb:PAK-interacting exchange factor beta(gene name synonym)|uniprotkb:Beta-Pix(gene name synonym)|uniprotkb:COOL-1(gene name synonym)|uniprotkb:p85(gene name synonym)|uniprotkb:Nbla10314(orf name)|uniprotkb:ARHGEF7(gene name)|psi-mi:ARHGEF7(display_short)|uniprotkb:COOL1(gene name synonym)|uniprotkb:KIAA0142(gene name synonym)|uniprotkb:P85SPR(gene name synonym)|uniprotkb:PAK3BP(gene name synonym)|uniprotkb:PIXB(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26508609|imex:IM-28561-409	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_001307782.1|refseq:NP_663788.1|refseq:NP_001106983.1|refseq:NP_001106984.1|refseq:NP_001106985.1|refseq:NP_001307780.1|refseq:NP_001307783.1|refseq:NP_001317526.1|refseq:NP_001317527.1|ensembl:ENSG00000102606(gene)|ensembl:ENST00000375741(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0007030"(Golgi organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0005925"(focal adhesion)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043005"(neuron projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0098794"(postsynapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1904424"(regulation of GTP binding)|go:"GO:1905833"(negative regulation of microtubule nucleation)|go:"GO:2000394"(positive regulation of lamellipodium morphogenesis)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035789|interpro:IPR035899|interpro:IPR036028|interpro:IPR036872|mint:Q14155|rcsb pdb:1BY1|rcsb pdb:1ZSG|rcsb pdb:2L3G|rcsb pdb:5SXP|reactome:R-HSA-182971|reactome:R-HSA-193648|reactome:R-HSA-3928664|reactome:R-HSA-416482|reactome:R-HSA-8980692|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013406|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-9013424|reactome:R-HSA-9619229|dip:DIP-40794N|refseq:NP_003890.1|refseq:XP_016876313.1|refseq:XP_016876314.1	-	-	-	figure legend:SF1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:0I59YglGXcYP7fFKIAWM6uCZY8Q9606	rigid:ik6io8OpseFovYPjR6YIslsKQ4g	false	glutathione s tranferase tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9BYB0	uniprotkb:P21333	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-350432|uniprotkb:Q8NF52|intact:EBI-1103234|ensembl:ENSP00000358866|uniprotkb:Q5HY53|uniprotkb:Q5HY55|uniprotkb:E9KL45	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:flna_human(display_long)|uniprotkb:FLNA(gene name)|psi-mi:FLNA(display_short)|uniprotkb:FLN(gene name synonym)|uniprotkb:FLN1(gene name synonym)|uniprotkb:Alpha-filamin(gene name synonym)|uniprotkb:Filamin-1(gene name synonym)|uniprotkb:Endothelial actin-binding protein(gene name synonym)|uniprotkb:Actin-binding protein 280(gene name synonym)|uniprotkb:Non-muscle filamin(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26508619|imex:IM-28561-1543	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	go:"GO:0007195"(adenylate cyclase-inhibiting dopamine receptor signaling pathway)|go:"GO:1902396"(protein localization to bicellular tight junction)|refseq:NP_001104026.1|refseq:NP_001447.2|ensembl:ENSG00000196924(gene)|ensembl:ENST00000369850(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048680"(positive regulation of axon regeneration)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051015"(actin filament binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0051764"(actin crosslink formation)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090042"(tubulin deacetylation)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0097368"(establishment of Sertoli cell barrier)|go:"GO:0097440"(apical dendrite)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901381"(positive regulation of potassium ion transmembrane transport)|go:"GO:0046332"(SMAD binding)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016479"(negative regulation of transcription by RNA polymerase I)|go:"GO:0019900"(kinase binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0021943"(formation of radial glial scaffolds)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030018"(Z disc)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031523"(Myb complex)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031852"(mu-type opioid receptor binding)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0032432"(actin filament bundle)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034988"(Fc-gamma receptor I complex binding)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043113"(receptor clustering)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045296"(cadherin binding)|reactome:R-HSA-114608|reactome:R-HSA-430116|reactome:R-HSA-446353|reactome:R-HSA-5627123|reactome:R-HSA-8983711|rcsb pdb:6EW1|go:"GO:1905031"(regulation of membrane repolarization during cardiac muscle cell action potential)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2001046"(positive regulation of integrin-mediated signaling pathway)|go:"GO:2001224"(positive regulation of neuron migration)|interpro:IPR001298(Filamin/ABP280 repeat)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR036872|interpro:IPR044801|mint:P21333|rcsb pdb:2AAV|rcsb pdb:2BP3|rcsb pdb:2BRQ|rcsb pdb:2J3S|rcsb pdb:2JF1|rcsb pdb:2K3T|rcsb pdb:2K7P|rcsb pdb:2K7Q|rcsb pdb:2MTP|rcsb pdb:2W0P|rcsb pdb:2WFN|rcsb pdb:3CNK|rcsb pdb:3HOC|rcsb pdb:3HOP|rcsb pdb:3HOR|rcsb pdb:3ISW|rcsb pdb:3RGH|rcsb pdb:4M9P|rcsb pdb:4P3W|rcsb pdb:5XR1|rcsb pdb:6D8C|go:"GO:1905000"(regulation of membrane repolarization during atrial cardiac muscle cell action potential)|dip:DIP-1136N	-	-	-	figure legend:SF1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:ZxGK5OSMy8cNsyt7Ax2KXb8bn9M9606	rigid:1S47v09Mf/PKE3ImjqAgNM+IgwI	false	glutathione s tranferase tag:?-?|sufficient binding region:1219-1731	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9BYB0	uniprotkb:P07910	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-357966|uniprotkb:P22628|uniprotkb:Q53EX2|uniprotkb:Q59FD3|uniprotkb:Q5FWE8|uniprotkb:Q86SF8|uniprotkb:Q86U45|uniprotkb:Q96HK7|uniprotkb:Q96HM4|uniprotkb:Q96IY5|uniprotkb:Q9BTS3|uniprotkb:D3DS19|uniprotkb:D3DS22|intact:EBI-28976506|ensembl:ENSP00000404848|ensembl:ENSP00000451291|ensembl:ENSP00000452276	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:hnrpc_human(display_long)|uniprotkb:HNRNPC(gene name)|psi-mi:HNRNPC(display_short)|uniprotkb:HNRPC(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26508631|imex:IM-28561-1325	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_001070910.1|refseq:NP_001070911.1|refseq:NP_004491.2|refseq:NP_112604.2|ensembl:ENSP00000404848|ensembl:ENST00000430246|ensembl:ENSP00000442816|ensembl:ENST00000553300|ensembl:ENSP00000450544|ensembl:ENSP00000451291|ensembl:ENST00000554969|ensembl:ENSP00000452276|ensembl:ENSP00000450725|ensembl:ENST00000555883|ensembl:ENSP00000450629|ensembl:ENST00000556628|ensembl:ENSP00000451652|ensembl:ENST00000556897|ensembl:ENSP00000451176|refseq:XP_011535010.1|refseq:XP_011535011.1|refseq:XP_011535012.1|refseq:XP_011535013.1|refseq:XP_011535014.1|refseq:XP_016876741.1|refseq:XP_016876742.1|dip:DIP-29854N|refseq:XP_006720188.1|ensembl:ENSG00000092199(gene)|ensembl:ENST00000420743(transcript)|ensembl:ENST00000554455(transcript)|ensembl:ENST00000557201(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000785"(chromatin)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0031492"(nucleosomal DNA binding)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043044"|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1990247"(N6-methyladenosine-containing RNA binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR017347(Heterogeneous nuclear ribonucleoprotein C, Raly)|interpro:IPR035979|mint:P07910|rcsb pdb:1TXP|rcsb pdb:1WF2|rcsb pdb:2MXY|rcsb pdb:2MZ1|rcsb pdb:3LN4|reactome:R-HSA-4570464|reactome:R-HSA-72163|reactome:R-HSA-72203|reactome:R-HSA-9013418|reactome:R-HSA-9013422	-	-	-	figure legend:SF1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:Fj5tiH0wrNUjTnsURIg8dB8laMg9606	rigid:b6H5gQgZa8WhsDfrX2GhWirnItU	false	glutathione s tranferase tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9BYB0	uniprotkb:O75525	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-722504|uniprotkb:Q6NUL8|uniprotkb:Q9UPA8|ensembl:ENSP00000348108	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:khdr3_human(display_long)|uniprotkb:Sam68-like mammalian protein 2(gene name synonym)|uniprotkb:Sam68-like phosphotyrosine protein(gene name synonym)|uniprotkb:RNA-binding protein T-Star(gene name synonym)|uniprotkb:KHDRBS3(gene name)|psi-mi:KHDRBS3(display_short)|uniprotkb:SALP(gene name synonym)|uniprotkb:SLM2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26508641|imex:IM-28561-1545	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_006549.1|ensembl:ENSG00000131773(gene)|ensembl:ENST00000355849(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0048024"(regulation of mRNA splicing, via spliceosome)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032335|interpro:IPR032571|interpro:IPR036612|mint:O75525|rcsb pdb:5EL3|rcsb pdb:5ELR|rcsb pdb:5ELS|rcsb pdb:5ELT|rcsb pdb:5EMO|reactome:R-HSA-8849468	-	-	-	figure legend:SF1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:9ZoB3JVp0Q9nxeFRsmWhNThzWoE9606	rigid:pLKEwyNio2dk53vXyu2U8REJyOI	false	glutathione s tranferase tag:?-?|sufficient binding region:791-1222	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9BYB0	uniprotkb:Q9NRD5	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-79165|uniprotkb:O95906|ensembl:ENSP00000349465|ensembl:ENSP00000385205|intact:EBI-2622151|uniprotkb:B3KS52	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:pick1_human(display_long)|uniprotkb:PICK1(gene name)|psi-mi:PICK1(display_short)|uniprotkb:PRKCABP(gene name synonym)|uniprotkb:Protein kinase C-alpha-binding protein(gene name synonym)|uniprotkb:Protein interacting with C kinase 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26508663|imex:IM-28561-1097	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	ensembl:ENSG00000100151(gene)|ensembl:ENST00000356976(transcript)|ensembl:ENST00000404072(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|refseq:NP_001034672.1|refseq:NP_001034673.1|refseq:NP_036539.1|go:"GO:0015844"(monoamine transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021782"(glial cell development)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0034315"(regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0034316"(negative regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0036294"(cellular response to decreased oxygen levels)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0043113"(receptor clustering)|go:"GO:0045161"(neuronal ion channel clustering)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051015"(actin filament binding)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0098842"(postsynaptic early endosome)|go:"GO:0140090"(membrane curvature sensor activity)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR010504(Arfaptin-like)|interpro:IPR027267|interpro:IPR030798|interpro:IPR036034|interpro:IPR037959|mint:Q9NRD5|rcsb pdb:2GZV|rcsb pdb:6AR4|rcsb pdb:6BJN|rcsb pdb:6BJO|reactome:R-HSA-202733|reactome:R-HSA-416993	-	-	-	figure legend:SF1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:qRx+eNG7We8Oe0SQOekqpJpn8zk9606	rigid:nPvxo/N7fbzdeVK0iUALbP9uxps	false	glutathione s tranferase tag:?-?|sufficient binding region:1219-1731	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9BYB0	uniprotkb:Q99435	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-946274|intact:EBI-2845314|uniprotkb:B7Z2U7|uniprotkb:B7Z5Q4|uniprotkb:B7Z9J5|uniprotkb:B7Z9U3|uniprotkb:Q96JS2|ensembl:ENSP00000390680|ensembl:ENSP00000394612	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:nell2_human(display_long)|uniprotkb:NELL2(gene name)|psi-mi:NELL2(display_short)|uniprotkb:NRP2(gene name synonym)|uniprotkb:NEL-like protein 2(gene name synonym)|uniprotkb:Nel-related protein 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26508653|imex:IM-28561-1101	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_001138579.1|refseq:NP_001138580.1|refseq:NP_001138581.1|refseq:NP_001138582.1|refseq:NP_006150.1|refseq:XP_011536698.1|refseq:XP_005268962.1|dip:DIP-49927N|ensembl:ENSG00000184613(gene)|ensembl:ENST00000429094(transcript)|ensembl:ENST00000452445(transcript)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0008201"(heparin binding)|go:"GO:0070050"(neuron cellular homeostasis)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR001791(Laminin G)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR018097|mint:Q99435|rcsb pdb:6POG|reactome:R-HSA-428542	-	-	-	figure legend:SF1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:/NYlmX9iC3H17WXd+u97CVwOD7c9606	rigid:Ewvf+9pvleRibJBVahuxh05jt2E	false	glutathione s tranferase tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9BYB0	uniprotkb:P55036	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-359318|uniprotkb:Q5VWC5|uniprotkb:Q9NS92|uniprotkb:D3DV16|ensembl:ENSP00000357879	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:psmd4_human(display_long)|uniprotkb:PSMD4(gene name)|psi-mi:PSMD4(display_short)|uniprotkb:MCB1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S5A(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN10(gene name synonym)|uniprotkb:Multiubiquitin chain-binding protein(gene name synonym)|uniprotkb:Antisecretory factor 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26508675|imex:IM-28561-647	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_002801.1|dip:DIP-38189N|ensembl:ENSG00000159352(gene)|ensembl:ENST00000368884(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043248"(proteasome assembly)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR036465|mint:P55036|rcsb pdb:1P9C|rcsb pdb:1P9D|rcsb pdb:1UEL|rcsb pdb:1YX4|rcsb pdb:1YX5|rcsb pdb:1YX6|rcsb pdb:2KDE|rcsb pdb:2KDF|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6MUN|rcsb pdb:6U19|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168	-	-	-	figure legend:SF1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:FTJG3ns3Ag/Y3xP3yEydGxppRcA9606	rigid:FEsGco2+sF9Qtsaa8PrdJ4YUmUI	false	glutathione s tranferase tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P49815	uniprotkb:Q9NRD5	intact:EBI-396587|uniprotkb:O75275|uniprotkb:Q8TAZ1|uniprotkb:A7E2E2|uniprotkb:B4DIQ7|uniprotkb:B4DRN2|uniprotkb:Q4LE71|uniprotkb:C9J378|ensembl:ENSP00000219476|uniprotkb:B4DIL8|uniprotkb:B7Z2B8	intact:EBI-79165|uniprotkb:O95906|ensembl:ENSP00000349465|ensembl:ENSP00000385205|intact:EBI-2622151|uniprotkb:B3KS52	psi-mi:tsc2_human(display_long)|uniprotkb:TSC2(gene name)|psi-mi:TSC2(display_short)|uniprotkb:Tuberous sclerosis 2 protein(gene name synonym)|uniprotkb:TSC4(gene name synonym)	psi-mi:pick1_human(display_long)|uniprotkb:PICK1(gene name)|psi-mi:PICK1(display_short)|uniprotkb:PRKCABP(gene name synonym)|uniprotkb:Protein kinase C-alpha-binding protein(gene name synonym)|uniprotkb:Protein interacting with C kinase 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26508755|imex:IM-28561-845	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000539.2|refseq:NP_001070651.1|refseq:NP_001107854.1|ensembl:ENSG00000103197(gene)|ensembl:ENST00000219476(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006897"(endocytosis)|go:"GO:0007507"(heart development)|go:"GO:0008104"(protein localization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|refseq:NP_001305756.1|refseq:NP_001305758.1|refseq:NP_001305760.1|refseq:NP_001305761.1|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043276"(anoikis)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:1901525"(negative regulation of mitophagy)|interpro:IPR000331(Rap/ran-GAP)|interpro:IPR003913(Tuberin)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018515|interpro:IPR024584|interpro:IPR027107|interpro:IPR035974|mint:P49815|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-198323|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674400|reactome:R-HSA-8854214|refseq:XP_005255586.2|refseq:XP_016879105.1	ensembl:ENSG00000100151(gene)|ensembl:ENST00000356976(transcript)|ensembl:ENST00000404072(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|refseq:NP_001034672.1|refseq:NP_001034673.1|refseq:NP_036539.1|go:"GO:0015844"(monoamine transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021782"(glial cell development)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0034315"(regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0034316"(negative regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0036294"(cellular response to decreased oxygen levels)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0043113"(receptor clustering)|go:"GO:0045161"(neuronal ion channel clustering)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051015"(actin filament binding)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0098842"(postsynaptic early endosome)|go:"GO:0140090"(membrane curvature sensor activity)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR010504(Arfaptin-like)|interpro:IPR027267|interpro:IPR030798|interpro:IPR036034|interpro:IPR037959|mint:Q9NRD5|rcsb pdb:2GZV|rcsb pdb:6AR4|rcsb pdb:6BJN|rcsb pdb:6BJO|reactome:R-HSA-202733|reactome:R-HSA-416993	-	-	-	figure legend:SF1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2020/10/05	2020/12/11	rogid:II0K3oybyrXfM4GEYMwV2ZyoWwE9606	rogid:qRx+eNG7We8Oe0SQOekqpJpn8zk9606	rigid:hOR6zGT+6IJwxyxKTfkayV348sQ	false	glutathione s tranferase tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q92574	uniprotkb:Q92844	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	intact:EBI-356349|uniprotkb:Q92885|uniprotkb:D3DPB5|ensembl:ENSP00000259075|ensembl:ENSP00000376505|uniprotkb:Q7Z4J6	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:tank_human(display_long)|uniprotkb:TANK(gene name)|psi-mi:TANK(display_short)|uniprotkb:ITRAF(gene name synonym)|uniprotkb:TRAF2(gene name synonym)|uniprotkb:TRAF-interacting protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26508745|imex:IM-28561-1099	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	refseq:NP_001186064.1|refseq:NP_004171.2|refseq:NP_597841.1|go:"GO:2000158"(positive regulation of ubiquitin-specific protease activity)|interpro:IPR024581|interpro:IPR039669|interpro:IPR041641|mint:Q92844|rcsb pdb:1KZZ|rcsb pdb:1L0A|rcsb pdb:5H10|reactome:R-HSA-9013973|reactome:R-HSA-933541|reactome:R-HSA-936964|go:"GO:1903003"(positive regulation of protein deubiquitination)|ensembl:ENST00000259075(transcript)|ensembl:ENST00000392749(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035800"(deubiquitinase activator activity)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071479"(cellular response to ionizing radiation)|ensembl:ENSG00000136560(gene)|refseq:XP_016858585.1|refseq:XP_016858586.1|dip:DIP-27516N	-	-	-	figure legend:SF1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2020/10/05	2020/12/11	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	rogid:B6PUVX1PZ5XmFszyF0tRSwfbb4M9606	rigid:t0M318upxSsd92FLpjdVhXbR2I8	false	glutathione s tranferase tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q92574	uniprotkb:Q9NRD5	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	intact:EBI-79165|uniprotkb:O95906|ensembl:ENSP00000349465|ensembl:ENSP00000385205|intact:EBI-2622151|uniprotkb:B3KS52	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:pick1_human(display_long)|uniprotkb:PICK1(gene name)|psi-mi:PICK1(display_short)|uniprotkb:PRKCABP(gene name synonym)|uniprotkb:Protein kinase C-alpha-binding protein(gene name synonym)|uniprotkb:Protein interacting with C kinase 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26508735|imex:IM-28561-1329	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	ensembl:ENSG00000100151(gene)|ensembl:ENST00000356976(transcript)|ensembl:ENST00000404072(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|refseq:NP_001034672.1|refseq:NP_001034673.1|refseq:NP_036539.1|go:"GO:0015844"(monoamine transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021782"(glial cell development)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0034315"(regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0034316"(negative regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0036294"(cellular response to decreased oxygen levels)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0043113"(receptor clustering)|go:"GO:0045161"(neuronal ion channel clustering)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051015"(actin filament binding)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0098842"(postsynaptic early endosome)|go:"GO:0140090"(membrane curvature sensor activity)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR010504(Arfaptin-like)|interpro:IPR027267|interpro:IPR030798|interpro:IPR036034|interpro:IPR037959|mint:Q9NRD5|rcsb pdb:2GZV|rcsb pdb:6AR4|rcsb pdb:6BJN|rcsb pdb:6BJO|reactome:R-HSA-202733|reactome:R-HSA-416993	-	-	-	figure legend:SF1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2020/10/05	2020/12/11	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	rogid:qRx+eNG7We8Oe0SQOekqpJpn8zk9606	rigid:mopCK0XYik+QTRZEYXKxaVqYFN4	false	glutathione s tranferase tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q92574	uniprotkb:Q674X7	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	intact:EBI-949239|uniprotkb:B0QYQ0|uniprotkb:B1AK78|uniprotkb:Q5TGF1|uniprotkb:Q674X6|uniprotkb:Q6ZUD1|uniprotkb:Q8IYN7|uniprotkb:Q8N409|uniprotkb:Q9UIL2|uniprotkb:Q674X4|ensembl:ENSP00000365198|uniprotkb:Q9UPX4|uniprotkb:B1AJZ1	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:kazrn_human(display_long)|uniprotkb:KIAA1026(gene name synonym)|uniprotkb:HRIHFB2003(orf name)|uniprotkb:KAZN(gene name)|psi-mi:KAZN(display_short)|uniprotkb:KAZ(gene name synonym)|uniprotkb:C1orf196(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26508725|imex:IM-28561-185	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	ensembl:ENSG00000189337(gene)|ensembl:ENST00000376030(transcript)|go:"GO:0001533"(cornified envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0016607"(nuclear speck)|go:"GO:0030057"(desmosome)|go:"GO:0031424"(keratinization)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR037613|interpro:IPR037614|interpro:IPR037615|interpro:IPR037616|mint:Q674X7|reactome:R-HSA-6809371|refseq:NP_001017999.1|refseq:NP_001018000.1|refseq:NP_001018001.1|refseq:NP_056024.1|refseq:NP_963922.2|refseq:XP_016856260.1	-	-	-	figure legend:SF1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2020/10/05	2020/12/11	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	rogid:Ai9moSFrBZMcWm4XWkk/vGzD5yE9606	rigid:GlJMXpGigRPf7WUbbttgfbIDyWQ	false	glutathione s tranferase tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q92574	uniprotkb:P02794	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	intact:EBI-713259|uniprotkb:Q3KRA8|uniprotkb:Q3SWW1|ensembl:ENSP00000273550|ensembl:ENSP00000484477|uniprotkb:B3KNR5	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:frih_human(display_long)|uniprotkb:Cell proliferation-inducing gene 15 protein(gene name synonym)|uniprotkb:FTH1(gene name)|psi-mi:FTH1(display_short)|uniprotkb:FTH(gene name synonym)|uniprotkb:FTHL6(gene name synonym)|uniprotkb:PIG15(orf name)|uniprotkb:OK/SW-cl.84(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26508715|imex:IM-28561-1327	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	refseq:NP_002023.2|ensembl:ENSG00000167996(gene)|ensembl:ENST00000273550(transcript)|ensembl:ENST00000620041(transcript)|go:"GO:0004322"(ferroxidase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006826"(iron ion transport)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0006880"(intracellular sequestering of iron ion)|go:"GO:0006955"(immune response)|go:"GO:0008043"(intracellular ferritin complex)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008199"(ferric iron binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0044754"(autolysosome)|mint:P02794|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:1FHA|rcsb pdb:2CEI|rcsb pdb:2CHI|rcsb pdb:2CIH|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR001519(Ferritin, N-terminal)|interpro:IPR008331(Ferritin and Dps)|interpro:IPR009040(Ferritin-like)|interpro:IPR009078(Ferritin/ribonucleotide reductase-like)|interpro:IPR012347(Ferritin-related)|interpro:IPR014034(Ferritin, conserved site)|rcsb pdb:2CLU|rcsb pdb:2CN6|rcsb pdb:2CN7|rcsb pdb:2FHA|rcsb pdb:2IU2|rcsb pdb:2Z6M|rcsb pdb:3AJO|rcsb pdb:3AJP|rcsb pdb:3AJQ|rcsb pdb:3ERZ|rcsb pdb:3ES3|rcsb pdb:4DYX|rcsb pdb:4DYY|rcsb pdb:4DYZ|rcsb pdb:4Y08|rcsb pdb:4YKH|rcsb pdb:4ZJK|rcsb pdb:5CMQ|rcsb pdb:5CMR|rcsb pdb:5GN8|rcsb pdb:5GOU|rcsb pdb:5JKK|rcsb pdb:5JKL|rcsb pdb:5JKM|rcsb pdb:5N26|rcsb pdb:5N27|rcsb pdb:5UP7|rcsb pdb:5UP8|rcsb pdb:5UP9|rcsb pdb:5VTD|rcsb pdb:5XB1|rcsb pdb:5YI5|rcsb pdb:5ZND|rcsb pdb:6B8F|rcsb pdb:6B8G|rcsb pdb:4DZ0|rcsb pdb:6FTV|rcsb pdb:6GSR|rcsb pdb:6H5I|rcsb pdb:6H6T|rcsb pdb:6H6U|rcsb pdb:6IPC|rcsb pdb:6IPO|rcsb pdb:6IPP|rcsb pdb:6IPQ|rcsb pdb:6J4A|rcsb pdb:6J7G|rcsb pdb:6JOB|rcsb pdb:6JPS|rcsb pdb:6KE2|rcsb pdb:6KE4|rcsb pdb:4OYN|rcsb pdb:6M52|rcsb pdb:6M54|rcsb pdb:6WYF|rcsb pdb:6WYG|rcsb pdb:6WYH|rcsb pdb:6Z6U|rcsb pdb:6Z9E|rcsb pdb:6Z9F|rcsb pdb:7A6A|rcsb pdb:7A6B|rcsb pdb:7CK8|rcsb pdb:7CK9|rcsb pdb:7JGK|rcsb pdb:7JGL|rcsb pdb:7JGM|rcsb pdb:7JGN|rcsb pdb:7JGO|rcsb pdb:7JGP|rcsb pdb:7JGQ|rcsb pdb:7K26|rcsb pdb:7K3V|rcsb pdb:7K3W|reactome:R-HSA-3000480|reactome:R-HSA-432722|reactome:R-HSA-6798695|reactome:R-HSA-917937|dip:DIP-38301N	-	-	-	figure legend:SF1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2020/10/05	2020/12/11	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	rogid:TchHgRpv+inA8BQ5i0OHaa267tQ9606	rigid:/dEAsMaVAr2dxEUpBCqqfyC2+XU	false	glutathione s tranferase tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P51531	uniprotkb:Q8TAQ2	intact:EBI-679562|uniprotkb:B1ALG3|uniprotkb:B1ALG4|uniprotkb:D3DRH4|uniprotkb:D3DRH5|ensembl:ENSP00000265773|ensembl:ENSP00000371638	intact:EBI-357418|ensembl:ENSP00000267064|uniprotkb:Q92923|uniprotkb:Q96E12|uniprotkb:Q96GY4|intact:EBI-1759986|intact:EBI-1965079|uniprotkb:F8VTJ5|uniprotkb:Q59GV3	psi-mi:smca2_human(display_long)|uniprotkb:ATP-dependent helicase SMARCA2(gene name synonym)|uniprotkb:SNF2-alpha(gene name synonym)|uniprotkb:SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2(gene name synonym)|uniprotkb:SMARCA2(gene name)|psi-mi:SMARCA2(display_short)|uniprotkb:BRM(gene name synonym)|uniprotkb:SNF2A(gene name synonym)|uniprotkb:SNF2L2(gene name synonym)|uniprotkb:BAF190B(gene name synonym)|uniprotkb:Protein brahma homolog(gene name synonym)|uniprotkb:BRG1-associated factor 190B(gene name synonym)	psi-mi:smrc2_human(display_long)|uniprotkb:SMARCC2(gene name)|psi-mi:SMARCC2(display_short)|uniprotkb:BAF170(gene name synonym)|uniprotkb:SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2(gene name synonym)|uniprotkb:SWI/SNF complex 170 kDa subunit(gene name synonym)|uniprotkb:BRG1-associated factor 170(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26508705|imex:IM-28561-649	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003061.3|refseq:NP_620614.2|refseq:NP_001276325.1|refseq:NP_001276326.1|dip:DIP-29005N|ensembl:ENSG00000080503(gene)|ensembl:ENST00000349721(transcript)|ensembl:ENST00000382203(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007286"(spermatid development)|go:"GO:0007399"(nervous system development)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0042393"(histone binding)|go:"GO:0043044"|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070615"|go:"GO:0071564"(npBAF complex)|go:"GO:0071565"(nBAF complex)|interpro:IPR000330(SNF2-related)|interpro:IPR001487(Bromodomain)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006576(BRK)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014012(Helicase/SANT-associated, DNA binding)|interpro:IPR014978(QLQ)|interpro:IPR018359|interpro:IPR027417|interpro:IPR029295|interpro:IPR030088|interpro:IPR036427|interpro:IPR037259|interpro:IPR038718|mint:P51531|rcsb pdb:2DAT|rcsb pdb:4QY4|rcsb pdb:5DKC|rcsb pdb:5DKH|rcsb pdb:6EG2|rcsb pdb:6EG3|rcsb pdb:6HAX|rcsb pdb:6HAY|rcsb pdb:6HAZ|reactome:R-HSA-3214858|reactome:R-HSA-8939243	ensembl:ENSG00000139613(gene)|ensembl:ENST00000267064(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006337"(nucleosome disassembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042393"(histone binding)|go:"GO:0043044"|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071564"(npBAF complex)|go:"GO:0071565"(nBAF complex)|interpro:IPR000953(Chromo domain)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR007526(SWIRM)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017884|interpro:IPR017930|interpro:IPR032448|interpro:IPR032450|interpro:IPR032451|interpro:IPR036388|interpro:IPR036420|interpro:IPR038044|mint:Q8TAQ2|rcsb pdb:6KAG|rcsb pdb:6LTH|rcsb pdb:6LTJ|reactome:R-HSA-3214858|reactome:R-HSA-8939243|refseq:NP_003066.2|refseq:NP_001123892.1|refseq:NP_620706.1|refseq:NP_001317217.1|dip:DIP-27611N	-	-	-	figure legend:SF1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2020/10/05	2020/12/11	rogid:DmQot4h4SmtqmUGBgF5ictTah289606	rogid:60gIB3J1YI/FzqVCzdoSg1Oj3ME9606	rigid:8enYUPIGsaUPkz956XiHtjHGTDU	false	glutathione s tranferase tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P51531	uniprotkb:Q9NRD5	intact:EBI-679562|uniprotkb:B1ALG3|uniprotkb:B1ALG4|uniprotkb:D3DRH4|uniprotkb:D3DRH5|ensembl:ENSP00000265773|ensembl:ENSP00000371638	intact:EBI-79165|uniprotkb:O95906|ensembl:ENSP00000349465|ensembl:ENSP00000385205|intact:EBI-2622151|uniprotkb:B3KS52	psi-mi:smca2_human(display_long)|uniprotkb:ATP-dependent helicase SMARCA2(gene name synonym)|uniprotkb:SNF2-alpha(gene name synonym)|uniprotkb:SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2(gene name synonym)|uniprotkb:SMARCA2(gene name)|psi-mi:SMARCA2(display_short)|uniprotkb:BRM(gene name synonym)|uniprotkb:SNF2A(gene name synonym)|uniprotkb:SNF2L2(gene name synonym)|uniprotkb:BAF190B(gene name synonym)|uniprotkb:Protein brahma homolog(gene name synonym)|uniprotkb:BRG1-associated factor 190B(gene name synonym)	psi-mi:pick1_human(display_long)|uniprotkb:PICK1(gene name)|psi-mi:PICK1(display_short)|uniprotkb:PRKCABP(gene name synonym)|uniprotkb:Protein kinase C-alpha-binding protein(gene name synonym)|uniprotkb:Protein interacting with C kinase 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26508695|imex:IM-28561-411	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003061.3|refseq:NP_620614.2|refseq:NP_001276325.1|refseq:NP_001276326.1|dip:DIP-29005N|ensembl:ENSG00000080503(gene)|ensembl:ENST00000349721(transcript)|ensembl:ENST00000382203(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007286"(spermatid development)|go:"GO:0007399"(nervous system development)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0042393"(histone binding)|go:"GO:0043044"|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070615"|go:"GO:0071564"(npBAF complex)|go:"GO:0071565"(nBAF complex)|interpro:IPR000330(SNF2-related)|interpro:IPR001487(Bromodomain)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006576(BRK)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014012(Helicase/SANT-associated, DNA binding)|interpro:IPR014978(QLQ)|interpro:IPR018359|interpro:IPR027417|interpro:IPR029295|interpro:IPR030088|interpro:IPR036427|interpro:IPR037259|interpro:IPR038718|mint:P51531|rcsb pdb:2DAT|rcsb pdb:4QY4|rcsb pdb:5DKC|rcsb pdb:5DKH|rcsb pdb:6EG2|rcsb pdb:6EG3|rcsb pdb:6HAX|rcsb pdb:6HAY|rcsb pdb:6HAZ|reactome:R-HSA-3214858|reactome:R-HSA-8939243	ensembl:ENSG00000100151(gene)|ensembl:ENST00000356976(transcript)|ensembl:ENST00000404072(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|refseq:NP_001034672.1|refseq:NP_001034673.1|refseq:NP_036539.1|go:"GO:0015844"(monoamine transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021782"(glial cell development)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0034315"(regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0034316"(negative regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0036294"(cellular response to decreased oxygen levels)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0043113"(receptor clustering)|go:"GO:0045161"(neuronal ion channel clustering)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051015"(actin filament binding)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0098842"(postsynaptic early endosome)|go:"GO:0140090"(membrane curvature sensor activity)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR010504(Arfaptin-like)|interpro:IPR027267|interpro:IPR030798|interpro:IPR036034|interpro:IPR037959|mint:Q9NRD5|rcsb pdb:2GZV|rcsb pdb:6AR4|rcsb pdb:6BJN|rcsb pdb:6BJO|reactome:R-HSA-202733|reactome:R-HSA-416993	-	-	-	figure legend:SF1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2020/10/05	2020/12/11	rogid:DmQot4h4SmtqmUGBgF5ictTah289606	rogid:qRx+eNG7We8Oe0SQOekqpJpn8zk9606	rigid:Ak23PepjBRasZnLOxjeRG2e6H20	false	glutathione s tranferase tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9BYB0	uniprotkb:Q8IXJ6	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-477232|uniprotkb:O95889|uniprotkb:Q924Y7|uniprotkb:Q9P0G8|uniprotkb:Q9UNT0|uniprotkb:Q9Y6E9|ensembl:ENSP00000249396|ensembl:ENSP00000489602|uniprotkb:A8K3V1|uniprotkb:B2RB45|uniprotkb:U5TP13	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:sir2_human(display_long)|uniprotkb:SIR2-like protein 2(gene name synonym)|uniprotkb:SIRT2(gene name)|psi-mi:SIRT2(display_short)|uniprotkb:SIR2L(gene name synonym)|uniprotkb:SIR2L2(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26508685|imex:IM-28561-1547	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	ensembl:ENSG00000068903(gene)|ensembl:ENSG00000283100(gene)|ensembl:ENST00000249396(transcript)|ensembl:ENST00000634533(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000183"(rDNA heterochromatin assembly)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000792"(heterochromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0006342"|go:"GO:0006348"|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006914"(autophagy)|go:"GO:0007084"(mitotic nuclear membrane reassembly)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0008134"(transcription factor binding)|rcsb pdb:6L66|rcsb pdb:6L71|rcsb pdb:6L72|rcsb pdb:6NR0|rcsb pdb:6QCN|rcsb pdb:7BOS|rcsb pdb:7BOT|reactome:R-HSA-2995383|rcsb pdb:5D7O|rcsb pdb:5D7P|rcsb pdb:5D7Q|rcsb pdb:5DY4|rcsb pdb:5DY5|rcsb pdb:5FYQ|rcsb pdb:5G4C|rcsb pdb:5MAR|rcsb pdb:5MAT|rcsb pdb:5Y0Z|rcsb pdb:5Y5N|rcsb pdb:5YQL|rcsb pdb:5YQM|rcsb pdb:5YQN|rcsb pdb:5YQO|rcsb pdb:6L65|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016575"(histone deacetylation)|go:"GO:0017136"(NAD-dependent histone deacetylase activity)|go:"GO:0021762"(substantia nigra development)|go:"GO:0022011"(myelination in peripheral nervous system)|go:"GO:0030426"(growth cone)|go:"GO:0030496"(midbody)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033010"(paranodal junction)|go:"GO:0033270"(paranode region of axon)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034979"(NAD-dependent protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042903"(tubulin deacetylase activity)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043204"(perikaryon)|go:"GO:0043209"(myelin sheath)|go:"GO:0043219"(lateral loop)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044242"(cellular lipid catabolic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045836"(positive regulation of meiotic nuclear division)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046970"("NAD-dependent histone deacetylase activity (H4-K16 specific)")|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051775"(response to redox state)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051987"(positive regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0061428"(negative regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061433"(cellular response to caloric restriction)|go:"GO:0070403"(NAD+ binding)|go:"GO:0070446"(negative regulation of oligodendrocyte progenitor proliferation)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0072686"(mitotic spindle)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090042"(tubulin deacetylation)|go:"GO:0097386"(glial cell projection)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|go:"GO:1900195"(positive regulation of oocyte maturation)|go:"GO:1900425"(negative regulation of defense response to bacterium)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000777"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR017328(NAD-dependent deacetylase sirtuin-2, eukaryota)|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|mint:Q8IXJ6|rcsb pdb:1J8F|rcsb pdb:3ZGO|rcsb pdb:3ZGV|rcsb pdb:4L3O|rcsb pdb:4R8M|rcsb pdb:4RMG|rcsb pdb:4RMH|rcsb pdb:4RMI|rcsb pdb:4RMJ|rcsb pdb:4X3O|rcsb pdb:4X3P|rcsb pdb:4Y6L|rcsb pdb:4Y6O|go:"GO:0051301"(cell division)|rcsb pdb:4Y6Q|refseq:NP_001180215.1|refseq:NP_036369.2|refseq:NP_085096.1|refseq:XP_011524956.1|refseq:XP_011524957.1|refseq:XP_006723174.1|dip:DIP-33350N	-	-	-	figure legend:SF1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:d4mOZOyT5RubJjE+a8wQhsWR6WI9606	rigid:HfFI/LwPXYij5Dl8Foy2md5B1P0	false	ha tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q05086	uniprotkb:Q14566	intact:EBI-954357|ensembl:ENSP00000497594|uniprotkb:P78355|uniprotkb:Q93066|uniprotkb:Q9UEP4|uniprotkb:Q9UEP5|uniprotkb:Q9UEP6|uniprotkb:Q9UEP7|uniprotkb:Q9UEP8|uniprotkb:Q9UEP9|uniprotkb:A8K8Z9	intact:EBI-374900|uniprotkb:Q13504|uniprotkb:Q99859|uniprotkb:B2R6H2|ensembl:ENSP00000264156	psi-mi:ube3a_human(display_long)|uniprotkb:E6AP ubiquitin-protein ligase(gene name synonym)|uniprotkb:Oncogenic protein-associated protein E6-AP(gene name synonym)|uniprotkb:Human papillomavirus E6-associated protein(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-54(gene name synonym)|uniprotkb:UBE3A(gene name)|psi-mi:UBE3A(display_short)|uniprotkb:E6AP(gene name synonym)|uniprotkb:EPVE6AP(gene name synonym)|uniprotkb:HPVE6A(gene name synonym)|uniprotkb:HECT-type ubiquitin transferase E3A(gene name synonym)	psi-mi:mcm6_human(display_long)|uniprotkb:MCM6(gene name)|psi-mi:MCM6(display_short)|uniprotkb:p105MCM(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26508765|imex:IM-28561-1331	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0060736"(prostate gland growth)|go:"GO:0061002"(negative regulation of dendritic spine morphogenesis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061743"(motor learning)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:1905528"(positive regulation of Golgi lumen acidification)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:2000058"(regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000569(HECT)|interpro:IPR017134(Ubiquitin-protein ligase E6-AP)|interpro:IPR032353|interpro:IPR035983|interpro:IPR042556|mint:Q05086|rcsb pdb:1C4Z|rcsb pdb:1D5F|rcsb pdb:1EQX|rcsb pdb:2KR1|rcsb pdb:4GIZ|rcsb pdb:4XR8|rcsb pdb:6SJV|rcsb pdb:6SLM|rcsb pdb:6TGK|rcsb pdb:6U19|reactome:R-HSA-983168|ensembl:ENSG00000114062(gene)|ensembl:ENST00000650110(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007420"(brain development)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032570"(response to progesterone)|go:"GO:0035037"(sperm entry)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0042220"(response to cocaine)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048511"(rhythmic process)|refseq:NP_000453.2|refseq:NP_570853.1|refseq:NP_570854.1|refseq:XP_016878033.1|refseq:XP_016878034.1|refseq:XP_011520296.1|refseq:XP_011520297.1|refseq:XP_016878035.1|refseq:XP_016878036.1|refseq:XP_016878037.1|refseq:XP_016878038.1|refseq:XP_016878039.1|dip:DIP-6002N|refseq:XP_005268324.1|refseq:XP_005268325.1|refseq:XP_005268326.1|refseq:XP_005268327.1|refseq:XP_005268328.1|refseq:XP_006720738.1|refseq:XP_006720739.1|refseq:XP_016878040.1|refseq:XP_016878041.1|refseq:XP_016878042.1|refseq:XP_016878043.1|refseq:XP_016878044.1	ensembl:ENST00000264156(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0042555"(MCM complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0071162"(CMG complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902969"(mitotic DNA replication)|ensembl:ENSG00000076003(gene)|reactome:R-HSA-68962|reactome:R-HSA-69052|interpro:IPR008049(MCM protein 6)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041024|interpro:IPR041562|interpro:IPR001208(MCM)|mint:Q14566|rcsb pdb:2KLQ|rcsb pdb:2LE8|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|refseq:NP_005906.2|dip:DIP-31727N	-	-	-	figure legend:SF1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2020/10/05	2020/12/11	rogid:w9T67+NDlHSd1tR+FgcX3LI1zpQ9606	rogid:gVpEwgfSwwxvP2T2CvCzIukthY49606	rigid:mD7AvBFAe3hk3U4ttqJvIgKQ3UM	false	glutathione s tranferase tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q05086	uniprotkb:P55036	intact:EBI-954357|ensembl:ENSP00000497594|uniprotkb:P78355|uniprotkb:Q93066|uniprotkb:Q9UEP4|uniprotkb:Q9UEP5|uniprotkb:Q9UEP6|uniprotkb:Q9UEP7|uniprotkb:Q9UEP8|uniprotkb:Q9UEP9|uniprotkb:A8K8Z9	intact:EBI-359318|uniprotkb:Q5VWC5|uniprotkb:Q9NS92|uniprotkb:D3DV16|ensembl:ENSP00000357879	psi-mi:ube3a_human(display_long)|uniprotkb:E6AP ubiquitin-protein ligase(gene name synonym)|uniprotkb:Oncogenic protein-associated protein E6-AP(gene name synonym)|uniprotkb:Human papillomavirus E6-associated protein(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-54(gene name synonym)|uniprotkb:UBE3A(gene name)|psi-mi:UBE3A(display_short)|uniprotkb:E6AP(gene name synonym)|uniprotkb:EPVE6AP(gene name synonym)|uniprotkb:HPVE6A(gene name synonym)|uniprotkb:HECT-type ubiquitin transferase E3A(gene name synonym)	psi-mi:psmd4_human(display_long)|uniprotkb:PSMD4(gene name)|psi-mi:PSMD4(display_short)|uniprotkb:MCB1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S5A(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN10(gene name synonym)|uniprotkb:Multiubiquitin chain-binding protein(gene name synonym)|uniprotkb:Antisecretory factor 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26508775|imex:IM-28561-413	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0060736"(prostate gland growth)|go:"GO:0061002"(negative regulation of dendritic spine morphogenesis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061743"(motor learning)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:1905528"(positive regulation of Golgi lumen acidification)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:2000058"(regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000569(HECT)|interpro:IPR017134(Ubiquitin-protein ligase E6-AP)|interpro:IPR032353|interpro:IPR035983|interpro:IPR042556|mint:Q05086|rcsb pdb:1C4Z|rcsb pdb:1D5F|rcsb pdb:1EQX|rcsb pdb:2KR1|rcsb pdb:4GIZ|rcsb pdb:4XR8|rcsb pdb:6SJV|rcsb pdb:6SLM|rcsb pdb:6TGK|rcsb pdb:6U19|reactome:R-HSA-983168|ensembl:ENSG00000114062(gene)|ensembl:ENST00000650110(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007420"(brain development)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032570"(response to progesterone)|go:"GO:0035037"(sperm entry)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0042220"(response to cocaine)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048511"(rhythmic process)|refseq:NP_000453.2|refseq:NP_570853.1|refseq:NP_570854.1|refseq:XP_016878033.1|refseq:XP_016878034.1|refseq:XP_011520296.1|refseq:XP_011520297.1|refseq:XP_016878035.1|refseq:XP_016878036.1|refseq:XP_016878037.1|refseq:XP_016878038.1|refseq:XP_016878039.1|dip:DIP-6002N|refseq:XP_005268324.1|refseq:XP_005268325.1|refseq:XP_005268326.1|refseq:XP_005268327.1|refseq:XP_005268328.1|refseq:XP_006720738.1|refseq:XP_006720739.1|refseq:XP_016878040.1|refseq:XP_016878041.1|refseq:XP_016878042.1|refseq:XP_016878043.1|refseq:XP_016878044.1	refseq:NP_002801.1|dip:DIP-38189N|ensembl:ENSG00000159352(gene)|ensembl:ENST00000368884(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043248"(proteasome assembly)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR036465|mint:P55036|rcsb pdb:1P9C|rcsb pdb:1P9D|rcsb pdb:1UEL|rcsb pdb:1YX4|rcsb pdb:1YX5|rcsb pdb:1YX6|rcsb pdb:2KDE|rcsb pdb:2KDF|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6MUN|rcsb pdb:6U19|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168	-	-	-	figure legend:SF1|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2020/10/05	2020/12/11	rogid:w9T67+NDlHSd1tR+FgcX3LI1zpQ9606	rogid:FTJG3ns3Ag/Y3xP3yEydGxppRcA9606	rigid:eGiR5eVVOXh4zzkLYpwcQ7YRtow	false	glutathione s tranferase tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O60759	uniprotkb:Q96QS3	intact:EBI-997814|intact:EBI-2803304|uniprotkb:Q15630|uniprotkb:Q8NE32|ensembl:ENSP00000264192|uniprotkb:B4DWH9	intact:EBI-11107474|ensembl:ENSP00000368332	psi-mi:cytip_human(display_long)|uniprotkb:Cytohesin-binding protein HE(gene name synonym)|uniprotkb:Cytohesin binder and regulator(gene name synonym)|uniprotkb:CYTIP(gene name)|psi-mi:CYTIP(display_short)|uniprotkb:PSCDBP(gene name synonym)|uniprotkb:Cytohesin-associated scaffolding protein(gene name synonym)|uniprotkb:Pleckstrin homology Sec7 and coiled-coil domains-binding protein(gene name synonym)	psi-mi:arx_human(display_long)|uniprotkb:ARX(gene name)|psi-mi:ARX(display_short)|uniprotkb:Aristaless-related homeobox(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26508816|imex:IM-28561-1551	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004279.3|ensembl:ENSG00000115165(gene)|ensembl:ENST00000264192(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0030155"(regulation of cell adhesion)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|mint:O60759|rcsb pdb:2Z17|refseq:XP_016860875.1	refseq:NP_620689.1|ensembl:ENSG00000004848(gene)|ensembl:ENST00000379044(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007411"(axon guidance)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0021759"(globus pallidus development)|go:"GO:0021800"(cerebral cortex tangential migration)|go:"GO:0021831"(embryonic olfactory bulb interneuron precursor migration)|go:"GO:0021846"(cell proliferation in forebrain)|go:"GO:0021853"(cerebral cortex GABAergic interneuron migration)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0044241"(lipid digestion)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0048484"(enteric nervous system development)|go:"GO:0072148"(epithelial cell fate commitment)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR003654(Paired-like homeodomain protein, OAR)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:2gBEQjAfTYfUd3I3QExqEP3zDtQ9606	rogid:rBLZYkByOhAZEXEvFVmWxRB3oN09606	rigid:w90kAyxyUu/x47t/fCVELtYx9HU	false	-	sufficient binding region:385-562	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q96QS3	uniprotkb:P50570	intact:EBI-11107474|ensembl:ENSP00000368332	intact:EBI-346547|uniprotkb:Q7Z5S3|uniprotkb:Q5I0Y0|uniprotkb:Q9UPH4|intact:EBI-3959204|uniprotkb:A8K1B6|uniprotkb:E7EV30|uniprotkb:K7ESI9|intact:EBI-5912046|uniprotkb:E9PEQ4|ensembl:ENSP00000347890	psi-mi:arx_human(display_long)|uniprotkb:ARX(gene name)|psi-mi:ARX(display_short)|uniprotkb:Aristaless-related homeobox(gene name synonym)	psi-mi:dyn2_human(display_long)|uniprotkb:DNM2(gene name)|psi-mi:DNM2(display_short)|uniprotkb:DYN2(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26508825|imex:IM-28561-207	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_620689.1|ensembl:ENSG00000004848(gene)|ensembl:ENST00000379044(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007411"(axon guidance)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0021759"(globus pallidus development)|go:"GO:0021800"(cerebral cortex tangential migration)|go:"GO:0021831"(embryonic olfactory bulb interneuron precursor migration)|go:"GO:0021846"(cell proliferation in forebrain)|go:"GO:0021853"(cerebral cortex GABAergic interneuron migration)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0044241"(lipid digestion)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0048484"(enteric nervous system development)|go:"GO:0072148"(epithelial cell fate commitment)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR003654(Paired-like homeodomain protein, OAR)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970	refseq:NP_004936.2|refseq:NP_001005360.1|refseq:NP_001005361.1|refseq:NP_001005362.1|refseq:NP_001177645.1|dip:DIP-31244N|reactome:R-HSA-203641|reactome:R-HSA-2132295|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-437239|reactome:R-HSA-8856828|reactome:R-HSA-9031628|reactome:R-HSA-196025|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031749"(D2 dopamine receptor binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033572"(transferrin transport)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044351"(macropinocytosis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050699"(WW domain binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0061024"(membrane organization)|go:"GO:0061025"(membrane fusion)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071245"(cellular response to carbon monoxide)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0098793"(presynapse)|go:"GO:0098844"(postsynaptic endocytic zone membrane)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902856"(negative regulation of non-motile cilium assembly)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903358"(regulation of Golgi organization)|go:"GO:1903408"("positive regulation of P-type sodium:potassium-exchanging transporter activity")|go:"GO:1903526"(negative regulation of membrane tubulation)|go:"GO:2000370"(positive regulation of clathrin-dependent endocytosis)|interpro:IPR000375(Dynamin central region)|interpro:IPR001401(Dynamin, GTPase region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR003130(Dynamin GTPase effector)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019762|interpro:IPR020850|interpro:IPR022812|interpro:IPR027188|interpro:IPR027417|interpro:IPR030381|mint:P50570|rcsb pdb:2YS1|reactome:R-HSA-166016|reactome:R-HSA-177504|reactome:R-HSA-190873|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008017"(microtubule binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016185"(synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|ensembl:ENSG00000079805(gene)|ensembl:ENST00000355667(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0001891"(phagocytic cup)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0003374"(dynamin family protein polymerization involved in mitochondrial fission)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005925"(focal adhesion)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0006897"(endocytosis)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:rBLZYkByOhAZEXEvFVmWxRB3oN09606	rogid:BAUEy6Iju72PTot46Xhz75cQTQs9606	rigid:VecGho/pp14lX+hQs7Mc78q3goo	false	sufficient binding region:385-562	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q96QS3	uniprotkb:P12814	intact:EBI-11107474|ensembl:ENSP00000368332	intact:EBI-351710|uniprotkb:Q9BTN1|uniprotkb:Q1HE25|uniprotkb:B7TY16|intact:EBI-3866221|uniprotkb:B3V8S3|uniprotkb:B4DHH3|ensembl:ENSP00000193403	psi-mi:arx_human(display_long)|uniprotkb:ARX(gene name)|psi-mi:ARX(display_short)|uniprotkb:Aristaless-related homeobox(gene name synonym)	psi-mi:actn1_human(display_long)|uniprotkb:ACTN1(gene name)|psi-mi:ACTN1(display_short)|uniprotkb:Alpha-actinin cytoskeletal isoform(gene name synonym)|uniprotkb:Non-muscle alpha-actinin-1(gene name synonym)|uniprotkb:F-actin cross-linking protein(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26508791|imex:IM-28561-1333	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_620689.1|ensembl:ENSG00000004848(gene)|ensembl:ENST00000379044(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007411"(axon guidance)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0021759"(globus pallidus development)|go:"GO:0021800"(cerebral cortex tangential migration)|go:"GO:0021831"(embryonic olfactory bulb interneuron precursor migration)|go:"GO:0021846"(cell proliferation in forebrain)|go:"GO:0021853"(cerebral cortex GABAergic interneuron migration)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0044241"(lipid digestion)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0048484"(enteric nervous system development)|go:"GO:0072148"(epithelial cell fate commitment)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR003654(Paired-like homeodomain protein, OAR)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970	refseq:NP_001093.1|refseq:NP_001123477.1|refseq:NP_001123476.1|dip:DIP-33184N|ensembl:ENSG00000072110(gene)|ensembl:ENST00000193403(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005916"(fascia adherens)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0017166"(vinculin binding)|go:"GO:0030018"(Z disc)|go:"GO:0030220"(platelet formation)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031143"(pseudopodium)|go:"GO:0036344"(platelet morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0042995"(cell projection)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051271"(negative regulation of cellular component movement)|go:"GO:0051639"(actin filament network formation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099186"(structural constituent of postsynapse)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR018247|interpro:IPR036872|mint:P12814|rcsb pdb:2EYI|rcsb pdb:2EYN|rcsb pdb:2N8Y|rcsb pdb:2N8Z|reactome:R-HSA-114608|reactome:R-HSA-3000170|reactome:R-HSA-373753|reactome:R-HSA-446388|reactome:R-HSA-9013405|reactome:R-HSA-9013418|reactome:R-HSA-9035034	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/09	rogid:rBLZYkByOhAZEXEvFVmWxRB3oN09606	rogid:guTURyt26f1ort4NAlYyabNc+WE9606	rigid:xAGTkZWMExLvbVWIXRvT12gYBDw	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q96QS3	uniprotkb:Q08117	intact:EBI-11107474|ensembl:ENSP00000368332	intact:EBI-717810|uniprotkb:Q12808|uniprotkb:Q96TG9|uniprotkb:Q9UDY9|uniprotkb:B2RBL0|uniprotkb:Q14CJ1|ensembl:ENSP00000317537	psi-mi:arx_human(display_long)|uniprotkb:ARX(gene name)|psi-mi:ARX(display_short)|uniprotkb:Aristaless-related homeobox(gene name synonym)	psi-mi:tle5_human(display_long)|uniprotkb:TLE5(gene name)|psi-mi:TLE5(display_short)|uniprotkb:AES(gene name synonym)|uniprotkb:Amino-terminal enhancer of split(gene name synonym)|uniprotkb:GRG(gene name synonym)|uniprotkb:GRG5(gene name synonym)|uniprotkb:Gp130-associated protein GAM(gene name synonym)|uniprotkb:Grg-5(gene name synonym)|uniprotkb:Groucho-related protein 5(gene name synonym)|uniprotkb:Protein ESP1(gene name synonym)|uniprotkb:Protein GRG(gene name synonym)|uniprotkb:TLE family member 5, transcriptional modulator(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26508807|imex:IM-28561-1549	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_620689.1|ensembl:ENSG00000004848(gene)|ensembl:ENST00000379044(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007411"(axon guidance)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0021759"(globus pallidus development)|go:"GO:0021800"(cerebral cortex tangential migration)|go:"GO:0021831"(embryonic olfactory bulb interneuron precursor migration)|go:"GO:0021846"(cell proliferation in forebrain)|go:"GO:0021853"(cerebral cortex GABAergic interneuron migration)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0044241"(lipid digestion)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0048484"(enteric nervous system development)|go:"GO:0072148"(epithelial cell fate commitment)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR003654(Paired-like homeodomain protein, OAR)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970	refseq:NP_001121.2|refseq:NP_945320.1|refseq:NP_945321.1|ensembl:ENSG00000104964(gene)|ensembl:ENST00000327141(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001501"(skeletal system development)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0007275"(multicellular organism development)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0040008"(regulation of growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0060761"(negative regulation of response to cytokine stimulus)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000210"(positive regulation of anoikis)|interpro:IPR005617(Groucho/TLE, N-terminal Q-rich region)|interpro:IPR009146(Groucho/transducin-like enhancer)|mint:Q08117|reactome:R-HSA-4641265|go:"GO:0032091"(negative regulation of protein binding)	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:rBLZYkByOhAZEXEvFVmWxRB3oN09606	rogid:eveYX2Rj6Oz431E8nGcTk4bUNt89606	rigid:muedDI/W0XJpSlc1N2nMFyklt3U	false	sufficient binding region:385-562	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q96QS3	uniprotkb:P35609	intact:EBI-11107474|ensembl:ENSP00000368332	intact:EBI-77797|uniprotkb:Q86TF4|ensembl:ENSP00000355537|uniprotkb:Q86TI8|uniprotkb:B1ANE4|intact:EBI-928705|uniprotkb:B2RCS5	psi-mi:arx_human(display_long)|uniprotkb:ARX(gene name)|psi-mi:ARX(display_short)|uniprotkb:Aristaless-related homeobox(gene name synonym)	psi-mi:actn2_human(display_long)|uniprotkb:ACTN2(gene name)|psi-mi:ACTN2(display_short)|uniprotkb:Alpha-actinin skeletal muscle isoform 2(gene name synonym)|uniprotkb:F-actin cross-linking protein(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26508798|imex:IM-28561-867	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_620689.1|ensembl:ENSG00000004848(gene)|ensembl:ENST00000379044(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007411"(axon guidance)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0021759"(globus pallidus development)|go:"GO:0021800"(cerebral cortex tangential migration)|go:"GO:0021831"(embryonic olfactory bulb interneuron precursor migration)|go:"GO:0021846"(cell proliferation in forebrain)|go:"GO:0021853"(cerebral cortex GABAergic interneuron migration)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0044241"(lipid digestion)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0048484"(enteric nervous system development)|go:"GO:0072148"(epithelial cell fate commitment)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR003654(Paired-like homeodomain protein, OAR)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970	refseq:NP_001094.1|ensembl:ENSG00000077522(gene)|ensembl:ENST00000366578(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005925"(focal adhesion)|go:"GO:0006936"(muscle contraction)|go:"GO:0007155"(cell adhesion)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030018"(Z disc)|go:"GO:0030035"(microspike assembly)|go:"GO:0030175"(filopodium)|go:"GO:0030274"(LIM domain binding)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031143"(pseudopodium)|go:"GO:0031432"(titin binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043267"(negative regulation of potassium ion transport)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045214"(sarcomere organization)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051015"(actin filament binding)|go:"GO:0051373"(FATZ binding)|go:"GO:0051695"(actin filament uncapping)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070080"(titin Z domain binding)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086097"(phospholipase C-activating angiotensin-activated signaling pathway)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|go:"GO:2001137"(positive regulation of endocytic recycling)|go:"GO:0030374"(nuclear receptor coactivator activity)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR036872|mint:P35609|rcsb pdb:1H8B|rcsb pdb:1HCI|rcsb pdb:1QUU|rcsb pdb:4D1E|rcsb pdb:5A36|rcsb pdb:5A37|rcsb pdb:5A38|rcsb pdb:5A4B|rcsb pdb:6SWT|rcsb pdb:6TS3|rcsb pdb:7A8T|rcsb pdb:7A8U|reactome:R-HSA-114608|go:"GO:2001259"(positive regulation of cation channel activity)|reactome:R-HSA-373753|reactome:R-HSA-390522|reactome:R-HSA-442982|reactome:R-HSA-5673001|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-9620244|reactome:R-HSA-438066|refseq:NP_001265272.1|refseq:NP_001265273.1|dip:DIP-383N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:rBLZYkByOhAZEXEvFVmWxRB3oN09606	rogid:9jws8DZxpttkzqPfDxEzORNnwcE9606	rigid:kai50HkHksaZknzK33XISxc0i8M	false	sufficient binding region:1-261	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q96QS3	uniprotkb:O94829	intact:EBI-11107474|ensembl:ENSP00000368332	intact:EBI-747310|uniprotkb:Q7LC04|uniprotkb:Q96HS3|uniprotkb:Q9H8N3|uniprotkb:Q9UFR1|uniprotkb:Q5T4X3|uniprotkb:D3DPY4|ensembl:ENSP00000361418	psi-mi:arx_human(display_long)|uniprotkb:ARX(gene name)|psi-mi:ARX(display_short)|uniprotkb:Aristaless-related homeobox(gene name synonym)	psi-mi:ipo13_human(display_long)|uniprotkb:Ran-binding protein 13(gene name synonym)|uniprotkb:Karyopherin-13(gene name synonym)|uniprotkb:IPO13(gene name)|psi-mi:IPO13(display_short)|uniprotkb:KIAA0724(gene name synonym)|uniprotkb:RANBP13(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26508834|imex:IM-28561-1103	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_620689.1|ensembl:ENSG00000004848(gene)|ensembl:ENST00000379044(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007411"(axon guidance)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0021759"(globus pallidus development)|go:"GO:0021800"(cerebral cortex tangential migration)|go:"GO:0021831"(embryonic olfactory bulb interneuron precursor migration)|go:"GO:0021846"(cell proliferation in forebrain)|go:"GO:0021853"(cerebral cortex GABAergic interneuron migration)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0044241"(lipid digestion)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0048484"(enteric nervous system development)|go:"GO:0072148"(epithelial cell fate commitment)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR003654(Paired-like homeodomain protein, OAR)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970	refseq:NP_055467.3|ensembl:ENSG00000117408(gene)|ensembl:ENST00000372343(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0031267"(small GTPase binding)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013598(Exportin-1/Importin-beta-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040520|interpro:IPR040709|interpro:IPR040944|rcsb pdb:2X19|rcsb pdb:2XWU|rcsb pdb:3ZJY	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:rBLZYkByOhAZEXEvFVmWxRB3oN09606	rogid:HC5CjdyfnwoVeE9JNHgicwFybWc9606	rigid:UBzIqxDv4Bc7/IAFWYFPFjdKEAM	false	sufficient binding region:260-400	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q13936	uniprotkb:Q8TCD1	intact:EBI-1038838|uniprotkb:Q13917|uniprotkb:Q13918|uniprotkb:Q13919|uniprotkb:Q13920|uniprotkb:Q13921|uniprotkb:Q13922|uniprotkb:Q13923|uniprotkb:Q13924|uniprotkb:Q13925|uniprotkb:Q13926|uniprotkb:Q13927|uniprotkb:Q13928|uniprotkb:Q13929|uniprotkb:Q13930|uniprotkb:Q13932|uniprotkb:Q13933|uniprotkb:Q14743|uniprotkb:Q14744|uniprotkb:Q15877|uniprotkb:Q4VMI7|uniprotkb:Q4VMI8|uniprotkb:Q4VMI9|uniprotkb:Q6PKM7|uniprotkb:Q8N6C0|uniprotkb:Q99025|uniprotkb:Q99241|uniprotkb:Q99875|uniprotkb:B2RUT3|uniprotkb:E9PDJ0	intact:EBI-2954747|ensembl:ENSP00000323199|ensembl:ENSP00000462538|ensembl:ENSP00000480941	psi-mi:cac1c_human(display_long)|uniprotkb:CACNA1C(gene name)|psi-mi:CACNA1C(display_short)|uniprotkb:CACH2(gene name synonym)|uniprotkb:CACN2(gene name synonym)|uniprotkb:CACNL1A1(gene name synonym)|uniprotkb:CCHL1A1(gene name synonym)|uniprotkb:Voltage-gated calcium channel subunit alpha Cav1.2(gene name synonym)|uniprotkb:Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle(gene name synonym)	psi-mi:cr032_human(display_long)|uniprotkb:C18orf32(gene name)|psi-mi:C18orf32(display_short)|uniprotkb:Putative NF-kappa-B-activating protein 200(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26508952|imex:IM-28561-215	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000710.5|refseq:NP_001123299.1|refseq:NP_001123301.1|refseq:NP_001123303.1|refseq:NP_001123304.1|refseq:NP_001123305.1|refseq:NP_001123306.1|refseq:NP_001123307.1|refseq:NP_001123314.1|refseq:NP_001123315.1|refseq:NP_001123308.1|refseq:NP_001123309.1|refseq:NP_001123310.1|refseq:NP_001123311.1|refseq:NP_001123312.1|refseq:NP_001123313.1|refseq:NP_001123316.1|refseq:NP_001123318.1|refseq:NP_001161095.1|refseq:NP_001161097.1|refseq:NP_001123302.2|refseq:NP_001161096.2|refseq:NP_955630.3|reactome:R-HSA-5576893|reactome:R-HSA-400042|reactome:R-HSA-419037|reactome:R-HSA-422356|go:"GO:0002520"(immune system development)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007507"(heart development)|go:"GO:0008331"(high voltage-gated calcium channel activity)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030425"(dendrite)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035585"(calcium-mediated signaling using extracellular calcium source)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043204"(perikaryon)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0061337"(cardiac conduction)|go:"GO:0061577"(calcium ion transmembrane transport via high voltage-gated calcium channel)|go:"GO:0070509"(calcium ion import)|go:"GO:0086002"(cardiac muscle cell action potential involved in contraction)|go:"GO:0086007"(voltage-gated calcium channel activity involved in cardiac muscle cell action potential)|go:"GO:0086012"(membrane depolarization during cardiac muscle cell action potential)|go:"GO:0086045"(membrane depolarization during AV node cell action potential)|go:"GO:0086056"(voltage-gated calcium channel activity involved in AV node cell action potential)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|go:"GO:0098912"(membrane depolarization during atrial cardiac muscle cell action potential)|go:"GO:1990454"(L-type voltage-gated calcium channel complex)|interpro:IPR002077(Voltage-dependent calcium channel, alpha-1 subunit)|interpro:IPR005446(Voltage-dependent calcium channel, L-type, alpha-1 subunit)|interpro:IPR005451(Voltage-dependent calcium channel, L-type, alpha-1C subunit)|interpro:IPR005821(Ion transport)|interpro:IPR014873(Voltage-dependent calcium channel, alpha-1 subunit, IQ domain)|interpro:IPR027359|interpro:IPR031649|interpro:IPR031688|rcsb pdb:1T0J|rcsb pdb:2BE6|rcsb pdb:2F3Y|rcsb pdb:2F3Z|rcsb pdb:2LQC|rcsb pdb:3G43|rcsb pdb:3OXQ|rcsb pdb:5V2P|rcsb pdb:5V2Q|rcsb pdb:6C0A|rcsb pdb:6DAD|rcsb pdb:6DAE|rcsb pdb:6DAF|rcsb pdb:6U39|rcsb pdb:6U3A|rcsb pdb:6U3B|rcsb pdb:6U3D|go:"GO:0070588"(calcium ion transmembrane transport)|reactome:R-HSA-5576892|dip:DIP-29589N	ensembl:ENSG00000177576(gene)|ensembl:ENST00000318240(transcript)|ensembl:ENST00000582392(transcript)|ensembl:ENST00000613385(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005811"(lipid droplet)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|interpro:IPR026776|refseq:NP_001186275.1|refseq:NP_001030177.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:dhWcWUTulWYd/nQtGorjr481/XA9606	rogid:udXB5FyG4ds2WFD5M0TXFcSvO8o9606	rigid:KmLCXLUC7DjidRffcPAMWUWAM+o	false	sufficient binding region:1841-2221	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q13936	uniprotkb:P35613	intact:EBI-1038838|uniprotkb:Q13917|uniprotkb:Q13918|uniprotkb:Q13919|uniprotkb:Q13920|uniprotkb:Q13921|uniprotkb:Q13922|uniprotkb:Q13923|uniprotkb:Q13924|uniprotkb:Q13925|uniprotkb:Q13926|uniprotkb:Q13927|uniprotkb:Q13928|uniprotkb:Q13929|uniprotkb:Q13930|uniprotkb:Q13932|uniprotkb:Q13933|uniprotkb:Q14743|uniprotkb:Q14744|uniprotkb:Q15877|uniprotkb:Q4VMI7|uniprotkb:Q4VMI8|uniprotkb:Q4VMI9|uniprotkb:Q6PKM7|uniprotkb:Q8N6C0|uniprotkb:Q99025|uniprotkb:Q99241|uniprotkb:Q99875|uniprotkb:B2RUT3|uniprotkb:E9PDJ0	intact:EBI-750709|uniprotkb:Q7Z796|uniprotkb:Q8IZL7|intact:EBI-2553051|uniprotkb:A6NJW1|uniprotkb:D3YLG5|ensembl:ENSP00000333769	psi-mi:cac1c_human(display_long)|uniprotkb:CACNA1C(gene name)|psi-mi:CACNA1C(display_short)|uniprotkb:CACH2(gene name synonym)|uniprotkb:CACN2(gene name synonym)|uniprotkb:CACNL1A1(gene name synonym)|uniprotkb:CCHL1A1(gene name synonym)|uniprotkb:Voltage-gated calcium channel subunit alpha Cav1.2(gene name synonym)|uniprotkb:Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle(gene name synonym)	psi-mi:basi_human(display_long)|uniprotkb:Leukocyte activation antigen M6(gene name synonym)|uniprotkb:Collagenase stimulatory factor(gene name synonym)|uniprotkb:Extracellular matrix metalloproteinase inducer(gene name synonym)|uniprotkb:5F7(gene name synonym)|uniprotkb:Tumor cell-derived collagenase stimulatory factor(gene name synonym)|uniprotkb:OK blood group antigen(gene name synonym)|uniprotkb:BSG(gene name)|psi-mi:BSG(display_short)|uniprotkb:UNQ6505/PRO21383(orf name)|uniprotkb:Hepatoma-associated antigen(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26508943|imex:IM-28561-1561	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000710.5|refseq:NP_001123299.1|refseq:NP_001123301.1|refseq:NP_001123303.1|refseq:NP_001123304.1|refseq:NP_001123305.1|refseq:NP_001123306.1|refseq:NP_001123307.1|refseq:NP_001123314.1|refseq:NP_001123315.1|refseq:NP_001123308.1|refseq:NP_001123309.1|refseq:NP_001123310.1|refseq:NP_001123311.1|refseq:NP_001123312.1|refseq:NP_001123313.1|refseq:NP_001123316.1|refseq:NP_001123318.1|refseq:NP_001161095.1|refseq:NP_001161097.1|refseq:NP_001123302.2|refseq:NP_001161096.2|refseq:NP_955630.3|reactome:R-HSA-5576893|reactome:R-HSA-400042|reactome:R-HSA-419037|reactome:R-HSA-422356|go:"GO:0002520"(immune system development)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007507"(heart development)|go:"GO:0008331"(high voltage-gated calcium channel activity)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030425"(dendrite)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035585"(calcium-mediated signaling using extracellular calcium source)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043204"(perikaryon)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0061337"(cardiac conduction)|go:"GO:0061577"(calcium ion transmembrane transport via high voltage-gated calcium channel)|go:"GO:0070509"(calcium ion import)|go:"GO:0086002"(cardiac muscle cell action potential involved in contraction)|go:"GO:0086007"(voltage-gated calcium channel activity involved in cardiac muscle cell action potential)|go:"GO:0086012"(membrane depolarization during cardiac muscle cell action potential)|go:"GO:0086045"(membrane depolarization during AV node cell action potential)|go:"GO:0086056"(voltage-gated calcium channel activity involved in AV node cell action potential)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|go:"GO:0098912"(membrane depolarization during atrial cardiac muscle cell action potential)|go:"GO:1990454"(L-type voltage-gated calcium channel complex)|interpro:IPR002077(Voltage-dependent calcium channel, alpha-1 subunit)|interpro:IPR005446(Voltage-dependent calcium channel, L-type, alpha-1 subunit)|interpro:IPR005451(Voltage-dependent calcium channel, L-type, alpha-1C subunit)|interpro:IPR005821(Ion transport)|interpro:IPR014873(Voltage-dependent calcium channel, alpha-1 subunit, IQ domain)|interpro:IPR027359|interpro:IPR031649|interpro:IPR031688|rcsb pdb:1T0J|rcsb pdb:2BE6|rcsb pdb:2F3Y|rcsb pdb:2F3Z|rcsb pdb:2LQC|rcsb pdb:3G43|rcsb pdb:3OXQ|rcsb pdb:5V2P|rcsb pdb:5V2Q|rcsb pdb:6C0A|rcsb pdb:6DAD|rcsb pdb:6DAE|rcsb pdb:6DAF|rcsb pdb:6U39|rcsb pdb:6U3A|rcsb pdb:6U3B|rcsb pdb:6U3D|go:"GO:0070588"(calcium ion transmembrane transport)|reactome:R-HSA-5576892|dip:DIP-29589N	refseq:NP_001719.2|refseq:NP_940991.1|refseq:NP_940993.1|refseq:NP_001309172.1|refseq:NP_940992.1|refseq:XP_016882662.1|dip:DIP-50310N|ensembl:ENSG00000172270(gene)|ensembl:ENST00000333511(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001525"(angiogenesis)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0002080"(acrosomal membrane)|go:"GO:0003407"(neural retina development)|go:"GO:0005537"(mannose binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007566"(embryo implantation)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030424"(axon)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0046598"(positive regulation of viral entry into host cell)|go:"GO:0046689"(response to mercury ion)|go:"GO:0046697"(decidualization)|go:"GO:0051591"(response to cAMP)|go:"GO:0061154"(endothelial tube morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070593"(dendrite self-avoidance)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098632"(cell-cell adhesion mediator activity)|go:"GO:1904466"(positive regulation of matrix metallopeptidase secretion)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR043204|interpro:IPR044157|mint:P35613|rcsb pdb:3B5H|rcsb pdb:3I84|rcsb pdb:3I85|rcsb pdb:3QQN|rcsb pdb:4U0Q|rcsb pdb:5X0T|rcsb pdb:5XF0|rcsb pdb:6LYY|rcsb pdb:6LZ0|rcsb pdb:7CKO|rcsb pdb:7CKR|rcsb pdb:7DA5|reactome:R-HSA-1474228|reactome:R-HSA-210991|reactome:R-HSA-216083|reactome:R-HSA-433692|reactome:R-HSA-5619070|reactome:R-HSA-70268|rcsb pdb:3QR2	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:dhWcWUTulWYd/nQtGorjr481/XA9606	rogid:jVbDR+TKBzTjXoxR4At6XQg59ZA9606	rigid:wv27RSqUW6KEu9AqyPhywuQBNHM	false	sufficient binding region:1841-2221	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q13936	uniprotkb:Q8N283	intact:EBI-1038838|uniprotkb:Q13917|uniprotkb:Q13918|uniprotkb:Q13919|uniprotkb:Q13920|uniprotkb:Q13921|uniprotkb:Q13922|uniprotkb:Q13923|uniprotkb:Q13924|uniprotkb:Q13925|uniprotkb:Q13926|uniprotkb:Q13927|uniprotkb:Q13928|uniprotkb:Q13929|uniprotkb:Q13930|uniprotkb:Q13932|uniprotkb:Q13933|uniprotkb:Q14743|uniprotkb:Q14744|uniprotkb:Q15877|uniprotkb:Q4VMI7|uniprotkb:Q4VMI8|uniprotkb:Q4VMI9|uniprotkb:Q6PKM7|uniprotkb:Q8N6C0|uniprotkb:Q99025|uniprotkb:Q99241|uniprotkb:Q99875|uniprotkb:B2RUT3|uniprotkb:E9PDJ0	intact:EBI-2813523|uniprotkb:B4DL62|uniprotkb:A6NEU0|uniprotkb:Q3MJ10|uniprotkb:Q96LS3|ensembl:ENSP00000347802	psi-mi:cac1c_human(display_long)|uniprotkb:CACNA1C(gene name)|psi-mi:CACNA1C(display_short)|uniprotkb:CACH2(gene name synonym)|uniprotkb:CACN2(gene name synonym)|uniprotkb:CACNL1A1(gene name synonym)|uniprotkb:CCHL1A1(gene name synonym)|uniprotkb:Voltage-gated calcium channel subunit alpha Cav1.2(gene name synonym)|uniprotkb:Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle(gene name synonym)	psi-mi:anr35_human(display_long)|uniprotkb:ANKRD35(gene name)|psi-mi:ANKRD35(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26508934|imex:IM-28561-1555	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000710.5|refseq:NP_001123299.1|refseq:NP_001123301.1|refseq:NP_001123303.1|refseq:NP_001123304.1|refseq:NP_001123305.1|refseq:NP_001123306.1|refseq:NP_001123307.1|refseq:NP_001123314.1|refseq:NP_001123315.1|refseq:NP_001123308.1|refseq:NP_001123309.1|refseq:NP_001123310.1|refseq:NP_001123311.1|refseq:NP_001123312.1|refseq:NP_001123313.1|refseq:NP_001123316.1|refseq:NP_001123318.1|refseq:NP_001161095.1|refseq:NP_001161097.1|refseq:NP_001123302.2|refseq:NP_001161096.2|refseq:NP_955630.3|reactome:R-HSA-5576893|reactome:R-HSA-400042|reactome:R-HSA-419037|reactome:R-HSA-422356|go:"GO:0002520"(immune system development)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007507"(heart development)|go:"GO:0008331"(high voltage-gated calcium channel activity)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030425"(dendrite)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035585"(calcium-mediated signaling using extracellular calcium source)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043204"(perikaryon)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0061337"(cardiac conduction)|go:"GO:0061577"(calcium ion transmembrane transport via high voltage-gated calcium channel)|go:"GO:0070509"(calcium ion import)|go:"GO:0086002"(cardiac muscle cell action potential involved in contraction)|go:"GO:0086007"(voltage-gated calcium channel activity involved in cardiac muscle cell action potential)|go:"GO:0086012"(membrane depolarization during cardiac muscle cell action potential)|go:"GO:0086045"(membrane depolarization during AV node cell action potential)|go:"GO:0086056"(voltage-gated calcium channel activity involved in AV node cell action potential)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|go:"GO:0098912"(membrane depolarization during atrial cardiac muscle cell action potential)|go:"GO:1990454"(L-type voltage-gated calcium channel complex)|interpro:IPR002077(Voltage-dependent calcium channel, alpha-1 subunit)|interpro:IPR005446(Voltage-dependent calcium channel, L-type, alpha-1 subunit)|interpro:IPR005451(Voltage-dependent calcium channel, L-type, alpha-1C subunit)|interpro:IPR005821(Ion transport)|interpro:IPR014873(Voltage-dependent calcium channel, alpha-1 subunit, IQ domain)|interpro:IPR027359|interpro:IPR031649|interpro:IPR031688|rcsb pdb:1T0J|rcsb pdb:2BE6|rcsb pdb:2F3Y|rcsb pdb:2F3Z|rcsb pdb:2LQC|rcsb pdb:3G43|rcsb pdb:3OXQ|rcsb pdb:5V2P|rcsb pdb:5V2Q|rcsb pdb:6C0A|rcsb pdb:6DAD|rcsb pdb:6DAE|rcsb pdb:6DAF|rcsb pdb:6U39|rcsb pdb:6U3A|rcsb pdb:6U3B|rcsb pdb:6U3D|go:"GO:0070588"(calcium ion transmembrane transport)|reactome:R-HSA-5576892|dip:DIP-29589N	ensembl:ENSG00000198483(gene)|ensembl:ENST00000355594(transcript)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|mint:Q8N283|refseq:NP_653299.4	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:dhWcWUTulWYd/nQtGorjr481/XA9606	rogid:gKpYjof24pm0XACs5Co0Kuu5gXc9606	rigid:VMtqpGzIbLEO2IR0/OkWi95rtQI	false	sufficient binding region:1841-2221	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q13936	uniprotkb:P35609	intact:EBI-1038838|uniprotkb:Q13917|uniprotkb:Q13918|uniprotkb:Q13919|uniprotkb:Q13920|uniprotkb:Q13921|uniprotkb:Q13922|uniprotkb:Q13923|uniprotkb:Q13924|uniprotkb:Q13925|uniprotkb:Q13926|uniprotkb:Q13927|uniprotkb:Q13928|uniprotkb:Q13929|uniprotkb:Q13930|uniprotkb:Q13932|uniprotkb:Q13933|uniprotkb:Q14743|uniprotkb:Q14744|uniprotkb:Q15877|uniprotkb:Q4VMI7|uniprotkb:Q4VMI8|uniprotkb:Q4VMI9|uniprotkb:Q6PKM7|uniprotkb:Q8N6C0|uniprotkb:Q99025|uniprotkb:Q99241|uniprotkb:Q99875|uniprotkb:B2RUT3|uniprotkb:E9PDJ0	intact:EBI-77797|uniprotkb:Q86TF4|ensembl:ENSP00000355537|uniprotkb:Q86TI8|uniprotkb:B1ANE4|intact:EBI-928705|uniprotkb:B2RCS5	psi-mi:cac1c_human(display_long)|uniprotkb:CACNA1C(gene name)|psi-mi:CACNA1C(display_short)|uniprotkb:CACH2(gene name synonym)|uniprotkb:CACN2(gene name synonym)|uniprotkb:CACNL1A1(gene name synonym)|uniprotkb:CCHL1A1(gene name synonym)|uniprotkb:Voltage-gated calcium channel subunit alpha Cav1.2(gene name synonym)|uniprotkb:Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle(gene name synonym)	psi-mi:actn2_human(display_long)|uniprotkb:ACTN2(gene name)|psi-mi:ACTN2(display_short)|uniprotkb:Alpha-actinin skeletal muscle isoform 2(gene name synonym)|uniprotkb:F-actin cross-linking protein(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26508925|imex:IM-28561-423	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000710.5|refseq:NP_001123299.1|refseq:NP_001123301.1|refseq:NP_001123303.1|refseq:NP_001123304.1|refseq:NP_001123305.1|refseq:NP_001123306.1|refseq:NP_001123307.1|refseq:NP_001123314.1|refseq:NP_001123315.1|refseq:NP_001123308.1|refseq:NP_001123309.1|refseq:NP_001123310.1|refseq:NP_001123311.1|refseq:NP_001123312.1|refseq:NP_001123313.1|refseq:NP_001123316.1|refseq:NP_001123318.1|refseq:NP_001161095.1|refseq:NP_001161097.1|refseq:NP_001123302.2|refseq:NP_001161096.2|refseq:NP_955630.3|reactome:R-HSA-5576893|reactome:R-HSA-400042|reactome:R-HSA-419037|reactome:R-HSA-422356|go:"GO:0002520"(immune system development)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007507"(heart development)|go:"GO:0008331"(high voltage-gated calcium channel activity)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030425"(dendrite)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035585"(calcium-mediated signaling using extracellular calcium source)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043204"(perikaryon)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0061337"(cardiac conduction)|go:"GO:0061577"(calcium ion transmembrane transport via high voltage-gated calcium channel)|go:"GO:0070509"(calcium ion import)|go:"GO:0086002"(cardiac muscle cell action potential involved in contraction)|go:"GO:0086007"(voltage-gated calcium channel activity involved in cardiac muscle cell action potential)|go:"GO:0086012"(membrane depolarization during cardiac muscle cell action potential)|go:"GO:0086045"(membrane depolarization during AV node cell action potential)|go:"GO:0086056"(voltage-gated calcium channel activity involved in AV node cell action potential)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|go:"GO:0098912"(membrane depolarization during atrial cardiac muscle cell action potential)|go:"GO:1990454"(L-type voltage-gated calcium channel complex)|interpro:IPR002077(Voltage-dependent calcium channel, alpha-1 subunit)|interpro:IPR005446(Voltage-dependent calcium channel, L-type, alpha-1 subunit)|interpro:IPR005451(Voltage-dependent calcium channel, L-type, alpha-1C subunit)|interpro:IPR005821(Ion transport)|interpro:IPR014873(Voltage-dependent calcium channel, alpha-1 subunit, IQ domain)|interpro:IPR027359|interpro:IPR031649|interpro:IPR031688|rcsb pdb:1T0J|rcsb pdb:2BE6|rcsb pdb:2F3Y|rcsb pdb:2F3Z|rcsb pdb:2LQC|rcsb pdb:3G43|rcsb pdb:3OXQ|rcsb pdb:5V2P|rcsb pdb:5V2Q|rcsb pdb:6C0A|rcsb pdb:6DAD|rcsb pdb:6DAE|rcsb pdb:6DAF|rcsb pdb:6U39|rcsb pdb:6U3A|rcsb pdb:6U3B|rcsb pdb:6U3D|go:"GO:0070588"(calcium ion transmembrane transport)|reactome:R-HSA-5576892|dip:DIP-29589N	refseq:NP_001094.1|ensembl:ENSG00000077522(gene)|ensembl:ENST00000366578(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005925"(focal adhesion)|go:"GO:0006936"(muscle contraction)|go:"GO:0007155"(cell adhesion)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030018"(Z disc)|go:"GO:0030035"(microspike assembly)|go:"GO:0030175"(filopodium)|go:"GO:0030274"(LIM domain binding)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031143"(pseudopodium)|go:"GO:0031432"(titin binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043267"(negative regulation of potassium ion transport)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045214"(sarcomere organization)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051015"(actin filament binding)|go:"GO:0051373"(FATZ binding)|go:"GO:0051695"(actin filament uncapping)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070080"(titin Z domain binding)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086097"(phospholipase C-activating angiotensin-activated signaling pathway)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|go:"GO:2001137"(positive regulation of endocytic recycling)|go:"GO:0030374"(nuclear receptor coactivator activity)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR036872|mint:P35609|rcsb pdb:1H8B|rcsb pdb:1HCI|rcsb pdb:1QUU|rcsb pdb:4D1E|rcsb pdb:5A36|rcsb pdb:5A37|rcsb pdb:5A38|rcsb pdb:5A4B|rcsb pdb:6SWT|rcsb pdb:6TS3|rcsb pdb:7A8T|rcsb pdb:7A8U|reactome:R-HSA-114608|go:"GO:2001259"(positive regulation of cation channel activity)|reactome:R-HSA-373753|reactome:R-HSA-390522|reactome:R-HSA-442982|reactome:R-HSA-5673001|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-9620244|reactome:R-HSA-438066|refseq:NP_001265272.1|refseq:NP_001265273.1|dip:DIP-383N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:dhWcWUTulWYd/nQtGorjr481/XA9606	rogid:9jws8DZxpttkzqPfDxEzORNnwcE9606	rigid:4yvHfnJzvJ8LyTJHIoeJDN761ng	false	sufficient binding region:1841-2221	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q13936	uniprotkb:P12814	intact:EBI-1038838|uniprotkb:Q13917|uniprotkb:Q13918|uniprotkb:Q13919|uniprotkb:Q13920|uniprotkb:Q13921|uniprotkb:Q13922|uniprotkb:Q13923|uniprotkb:Q13924|uniprotkb:Q13925|uniprotkb:Q13926|uniprotkb:Q13927|uniprotkb:Q13928|uniprotkb:Q13929|uniprotkb:Q13930|uniprotkb:Q13932|uniprotkb:Q13933|uniprotkb:Q14743|uniprotkb:Q14744|uniprotkb:Q15877|uniprotkb:Q4VMI7|uniprotkb:Q4VMI8|uniprotkb:Q4VMI9|uniprotkb:Q6PKM7|uniprotkb:Q8N6C0|uniprotkb:Q99025|uniprotkb:Q99241|uniprotkb:Q99875|uniprotkb:B2RUT3|uniprotkb:E9PDJ0	intact:EBI-351710|uniprotkb:Q9BTN1|uniprotkb:Q1HE25|uniprotkb:B7TY16|intact:EBI-3866221|uniprotkb:B3V8S3|uniprotkb:B4DHH3|ensembl:ENSP00000193403	psi-mi:cac1c_human(display_long)|uniprotkb:CACNA1C(gene name)|psi-mi:CACNA1C(display_short)|uniprotkb:CACH2(gene name synonym)|uniprotkb:CACN2(gene name synonym)|uniprotkb:CACNL1A1(gene name synonym)|uniprotkb:CCHL1A1(gene name synonym)|uniprotkb:Voltage-gated calcium channel subunit alpha Cav1.2(gene name synonym)|uniprotkb:Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle(gene name synonym)	psi-mi:actn1_human(display_long)|uniprotkb:ACTN1(gene name)|psi-mi:ACTN1(display_short)|uniprotkb:Alpha-actinin cytoskeletal isoform(gene name synonym)|uniprotkb:Non-muscle alpha-actinin-1(gene name synonym)|uniprotkb:F-actin cross-linking protein(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26508916|imex:IM-28561-213	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000710.5|refseq:NP_001123299.1|refseq:NP_001123301.1|refseq:NP_001123303.1|refseq:NP_001123304.1|refseq:NP_001123305.1|refseq:NP_001123306.1|refseq:NP_001123307.1|refseq:NP_001123314.1|refseq:NP_001123315.1|refseq:NP_001123308.1|refseq:NP_001123309.1|refseq:NP_001123310.1|refseq:NP_001123311.1|refseq:NP_001123312.1|refseq:NP_001123313.1|refseq:NP_001123316.1|refseq:NP_001123318.1|refseq:NP_001161095.1|refseq:NP_001161097.1|refseq:NP_001123302.2|refseq:NP_001161096.2|refseq:NP_955630.3|reactome:R-HSA-5576893|reactome:R-HSA-400042|reactome:R-HSA-419037|reactome:R-HSA-422356|go:"GO:0002520"(immune system development)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007507"(heart development)|go:"GO:0008331"(high voltage-gated calcium channel activity)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030425"(dendrite)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035585"(calcium-mediated signaling using extracellular calcium source)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043204"(perikaryon)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0061337"(cardiac conduction)|go:"GO:0061577"(calcium ion transmembrane transport via high voltage-gated calcium channel)|go:"GO:0070509"(calcium ion import)|go:"GO:0086002"(cardiac muscle cell action potential involved in contraction)|go:"GO:0086007"(voltage-gated calcium channel activity involved in cardiac muscle cell action potential)|go:"GO:0086012"(membrane depolarization during cardiac muscle cell action potential)|go:"GO:0086045"(membrane depolarization during AV node cell action potential)|go:"GO:0086056"(voltage-gated calcium channel activity involved in AV node cell action potential)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|go:"GO:0098912"(membrane depolarization during atrial cardiac muscle cell action potential)|go:"GO:1990454"(L-type voltage-gated calcium channel complex)|interpro:IPR002077(Voltage-dependent calcium channel, alpha-1 subunit)|interpro:IPR005446(Voltage-dependent calcium channel, L-type, alpha-1 subunit)|interpro:IPR005451(Voltage-dependent calcium channel, L-type, alpha-1C subunit)|interpro:IPR005821(Ion transport)|interpro:IPR014873(Voltage-dependent calcium channel, alpha-1 subunit, IQ domain)|interpro:IPR027359|interpro:IPR031649|interpro:IPR031688|rcsb pdb:1T0J|rcsb pdb:2BE6|rcsb pdb:2F3Y|rcsb pdb:2F3Z|rcsb pdb:2LQC|rcsb pdb:3G43|rcsb pdb:3OXQ|rcsb pdb:5V2P|rcsb pdb:5V2Q|rcsb pdb:6C0A|rcsb pdb:6DAD|rcsb pdb:6DAE|rcsb pdb:6DAF|rcsb pdb:6U39|rcsb pdb:6U3A|rcsb pdb:6U3B|rcsb pdb:6U3D|go:"GO:0070588"(calcium ion transmembrane transport)|reactome:R-HSA-5576892|dip:DIP-29589N	refseq:NP_001093.1|refseq:NP_001123477.1|refseq:NP_001123476.1|dip:DIP-33184N|ensembl:ENSG00000072110(gene)|ensembl:ENST00000193403(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005916"(fascia adherens)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0017166"(vinculin binding)|go:"GO:0030018"(Z disc)|go:"GO:0030220"(platelet formation)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031143"(pseudopodium)|go:"GO:0036344"(platelet morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0042995"(cell projection)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051271"(negative regulation of cellular component movement)|go:"GO:0051639"(actin filament network formation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099186"(structural constituent of postsynapse)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR018247|interpro:IPR036872|mint:P12814|rcsb pdb:2EYI|rcsb pdb:2EYN|rcsb pdb:2N8Y|rcsb pdb:2N8Z|reactome:R-HSA-114608|reactome:R-HSA-3000170|reactome:R-HSA-373753|reactome:R-HSA-446388|reactome:R-HSA-9013405|reactome:R-HSA-9013418|reactome:R-HSA-9035034	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:dhWcWUTulWYd/nQtGorjr481/XA9606	rogid:guTURyt26f1ort4NAlYyabNc+WE9606	rigid:S6xtVDT26nTMUwNNoG5CWsXsIqU	false	sufficient binding region:1841-2221	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P46100	uniprotkb:Q9ULU4	intact:EBI-396461|ensembl:ENSP00000362441|ensembl:ENSP00000378967|uniprotkb:P51068|uniprotkb:Q15886|uniprotkb:Q59FB5|uniprotkb:Q59H31|uniprotkb:Q5H9A2|uniprotkb:Q5JWI4|uniprotkb:Q7Z2J1|uniprotkb:Q9H0Z1|uniprotkb:Q9NTS3|uniprotkb:D3DTE2	intact:EBI-765834|uniprotkb:Q13517|uniprotkb:Q4JJ94|uniprotkb:Q4JJ95|uniprotkb:Q5TH09|uniprotkb:Q6MZM1|uniprotkb:Q8WXC5|uniprotkb:Q9H1F3|uniprotkb:Q9H1F4|uniprotkb:Q9H1F5|uniprotkb:Q9H1L8|uniprotkb:Q9H1L9|uniprotkb:Q9H2G5|uniprotkb:Q9NYN3|uniprotkb:Q9UIX6|uniprotkb:Q2HXV7|uniprotkb:E1P5U5|uniprotkb:B7Z680|uniprotkb:Q2HXV2|uniprotkb:Q2HXV8|uniprotkb:Q2HXW0|uniprotkb:Q2HXW1|uniprotkb:Q2HXW2|uniprotkb:Q2HXV4|uniprotkb:Q2HXV9|uniprotkb:B3KVL2|uniprotkb:B7Z2A8|uniprotkb:B7Z3E0|uniprotkb:B7ZM62|uniprotkb:F5H0X3|uniprotkb:H7C0U2|uniprotkb:J3KPU3|uniprotkb:Q2HXV1|uniprotkb:Q2HXV3|uniprotkb:Q5TH11|ensembl:ENSP00000312237	psi-mi:atrx_human(display_long)|uniprotkb:ATRX(gene name)|psi-mi:ATRX(display_short)|uniprotkb:RAD54L(gene name synonym)|uniprotkb:XH2(gene name synonym)|uniprotkb:ATP-dependent helicase ATRX(gene name synonym)|uniprotkb:X-linked helicase II(gene name synonym)|uniprotkb:X-linked nuclear protein(gene name synonym)|uniprotkb:Znf-HX(gene name synonym)	psi-mi:pkcb1_human(display_long)|uniprotkb:Rack7(gene name synonym)|uniprotkb:Cutaneous T-cell lymphoma-associated antigen se14-3(gene name synonym)|uniprotkb:Zinc finger MYND domain-containing protein 8(gene name synonym)|uniprotkb:ZMYND8(gene name)|psi-mi:ZMYND8(display_short)|uniprotkb:KIAA1125(gene name synonym)|uniprotkb:RACK7(gene name synonym)|uniprotkb:PRKCBP1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26508907|imex:IM-28561-421	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000085224(gene)|go:"GO:0015616"(DNA translocase activity)|ensembl:ENST00000373344(transcript)|ensembl:ENST00000395603(transcript)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000792"(heterochromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003682"(chromatin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0006281"(DNA repair)|go:"GO:0006306"(DNA methylation)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0016604"(nuclear body)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010571"(positive regulation of nuclear cell cycle DNA replication)|go:"GO:0016605"(PML body)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030900"(forebrain development)|go:"GO:0031297"(replication fork processing)|go:"GO:0032206"(positive regulation of telomere maintenance)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035128"(post-embryonic forelimb morphogenesis)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042393"(histone binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0060009"(Sertoli cell development)|go:"GO:0070087"(chromo shadow domain binding)|go:"GO:0070192"(chromosome organization involved in meiotic cell cycle)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0070615"|go:"GO:0072520"(seminiferous tubule development)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0099115"(chromosome, subtelomeric region)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1900112"(regulation of histone H3-K9 trimethylation)|go:"GO:1901581"(negative regulation of telomeric RNA transcription from RNA pol II promoter)|go:"GO:1901582"(positive regulation of telomeric RNA transcription from RNA pol II promoter)|go:"GO:1904908"(negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric)|interpro:IPR000330(SNF2-related)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR025766|interpro:IPR027417|interpro:IPR038718|interpro:IPR041430|mint:P46100|rcsb pdb:2JM1|rcsb pdb:2LBM|rcsb pdb:2LD1|rcsb pdb:3QL9|rcsb pdb:3QLA|rcsb pdb:3QLC|rcsb pdb:3QLN|rcsb pdb:4W5A|rcsb pdb:5GRQ|rcsb pdb:5Y18|rcsb pdb:5Y6O|rcsb pdb:6G0O|reactome:R-HSA-9670095|reactome:R-HSA-9670613|reactome:R-HSA-9670615|refseq:NP_000480.3|refseq:NP_612114.2|dip:DIP-31532N	refseq:NP_036540.3|refseq:NP_898868.1|refseq:NP_898869.1|refseq:XP_011527053.1|refseq:NP_001268711.1|refseq:NP_001268706.1|refseq:NP_001268710.1|ensembl:ENST00000262975|ensembl:ENSP00000262975|ensembl:ENSP00000312237|ensembl:ENST00000352431|ensembl:ENSP00000335537|ensembl:ENST00000355972|ensembl:ENSP00000348246|ensembl:ENST00000360911|ensembl:ENSP00000354166|ensembl:ENST00000372023|ensembl:ENSP00000361093|ensembl:ENST00000396281|ensembl:ENSP00000379577|refseq:NP_001268702.1|refseq:NP_001268703.1|refseq:NP_001268704.1|refseq:NP_001268705.1|refseq:NP_001268707.1|refseq:NP_001268712.1|refseq:XP_005260417.1|refseq:XP_005260423.1|ensembl:ENST00000446994|ensembl:ENSP00000396725|ensembl:ENST00000458360|ensembl:ENSP00000392964|ensembl:ENST00000461685|ensembl:ENSP00000418210|ensembl:ENST00000471951|ensembl:ENSP00000420095|ensembl:ENST00000536340|ensembl:ENSP00000439800|ensembl:ENST00000540497|ensembl:ENSP00000443086|refseq:NP_001268713.1|refseq:XP_005260413.1|refseq:NP_001268700.1|refseq:NP_001268701.1|refseq:XP_006723825.1|refseq:XP_016883250.1|refseq:XP_016883256.1|refseq:XP_016883257.1|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0035064"(methylated histone binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:0098815"(modulation of excitatory postsynaptic potential)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902897"(regulation of postsynaptic density protein 95 clustering)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|interpro:IPR000313(PWWP)|interpro:IPR001487(Bromodomain)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002893(Zinc finger, MYND-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR021931|interpro:IPR035505|interpro:IPR036427|interpro:IPR037967|interpro:IPR044075|mint:Q9ULU4|rcsb pdb:4COS|rcsb pdb:5B73|rcsb pdb:5MQ4|go:"GO:0005654"(nucleoplasm)|rcsb pdb:5Y1Z|ensembl:ENSG00000101040(gene)|ensembl:ENST00000311275(transcript)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:3t+VQYWuUjQQSuDSQ0Urst2hha09606	rogid:z46jFcDnmKauE75GMeApPZmfdDM9606	rigid:wIYeb+XlTdeVuPjiAAWjQX2jgLc	false	sufficient binding region:2153-2492	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q13936	uniprotkb:Q96EY1	intact:EBI-1038838|uniprotkb:Q13917|uniprotkb:Q13918|uniprotkb:Q13919|uniprotkb:Q13920|uniprotkb:Q13921|uniprotkb:Q13922|uniprotkb:Q13923|uniprotkb:Q13924|uniprotkb:Q13925|uniprotkb:Q13926|uniprotkb:Q13927|uniprotkb:Q13928|uniprotkb:Q13929|uniprotkb:Q13930|uniprotkb:Q13932|uniprotkb:Q13933|uniprotkb:Q14743|uniprotkb:Q14744|uniprotkb:Q15877|uniprotkb:Q4VMI7|uniprotkb:Q4VMI8|uniprotkb:Q4VMI9|uniprotkb:Q6PKM7|uniprotkb:Q8N6C0|uniprotkb:Q99025|uniprotkb:Q99241|uniprotkb:Q99875|uniprotkb:B2RUT3|uniprotkb:E9PDJ0	intact:EBI-356767|uniprotkb:O75472|uniprotkb:Q8WUJ6|uniprotkb:Q8WXJ3|uniprotkb:Q96D76|uniprotkb:Q96IV1|uniprotkb:Q9NYH8|uniprotkb:B2RAJ5|uniprotkb:B4DI33|uniprotkb:E7ES32|ensembl:ENSP00000262375|ensembl:ENSP00000477570	psi-mi:cac1c_human(display_long)|uniprotkb:CACNA1C(gene name)|psi-mi:CACNA1C(display_short)|uniprotkb:CACH2(gene name synonym)|uniprotkb:CACN2(gene name synonym)|uniprotkb:CACNL1A1(gene name synonym)|uniprotkb:CCHL1A1(gene name synonym)|uniprotkb:Voltage-gated calcium channel subunit alpha Cav1.2(gene name synonym)|uniprotkb:Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle(gene name synonym)	psi-mi:dnja3_human(display_long)|uniprotkb:DNAJA3(gene name)|psi-mi:DNAJA3(display_short)|uniprotkb:TID1(gene name synonym)|uniprotkb:HCA57(gene name synonym)|uniprotkb:Tumorous imaginal discs protein Tid56 homolog(gene name synonym)|uniprotkb:DnaJ protein Tid-1(gene name synonym)|uniprotkb:Hepatocellular carcinoma-associated antigen 57(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26508961|imex:IM-28561-869	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000710.5|refseq:NP_001123299.1|refseq:NP_001123301.1|refseq:NP_001123303.1|refseq:NP_001123304.1|refseq:NP_001123305.1|refseq:NP_001123306.1|refseq:NP_001123307.1|refseq:NP_001123314.1|refseq:NP_001123315.1|refseq:NP_001123308.1|refseq:NP_001123309.1|refseq:NP_001123310.1|refseq:NP_001123311.1|refseq:NP_001123312.1|refseq:NP_001123313.1|refseq:NP_001123316.1|refseq:NP_001123318.1|refseq:NP_001161095.1|refseq:NP_001161097.1|refseq:NP_001123302.2|refseq:NP_001161096.2|refseq:NP_955630.3|reactome:R-HSA-5576893|reactome:R-HSA-400042|reactome:R-HSA-419037|reactome:R-HSA-422356|go:"GO:0002520"(immune system development)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007507"(heart development)|go:"GO:0008331"(high voltage-gated calcium channel activity)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030425"(dendrite)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035585"(calcium-mediated signaling using extracellular calcium source)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043204"(perikaryon)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0061337"(cardiac conduction)|go:"GO:0061577"(calcium ion transmembrane transport via high voltage-gated calcium channel)|go:"GO:0070509"(calcium ion import)|go:"GO:0086002"(cardiac muscle cell action potential involved in contraction)|go:"GO:0086007"(voltage-gated calcium channel activity involved in cardiac muscle cell action potential)|go:"GO:0086012"(membrane depolarization during cardiac muscle cell action potential)|go:"GO:0086045"(membrane depolarization during AV node cell action potential)|go:"GO:0086056"(voltage-gated calcium channel activity involved in AV node cell action potential)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|go:"GO:0098912"(membrane depolarization during atrial cardiac muscle cell action potential)|go:"GO:1990454"(L-type voltage-gated calcium channel complex)|interpro:IPR002077(Voltage-dependent calcium channel, alpha-1 subunit)|interpro:IPR005446(Voltage-dependent calcium channel, L-type, alpha-1 subunit)|interpro:IPR005451(Voltage-dependent calcium channel, L-type, alpha-1C subunit)|interpro:IPR005821(Ion transport)|interpro:IPR014873(Voltage-dependent calcium channel, alpha-1 subunit, IQ domain)|interpro:IPR027359|interpro:IPR031649|interpro:IPR031688|rcsb pdb:1T0J|rcsb pdb:2BE6|rcsb pdb:2F3Y|rcsb pdb:2F3Z|rcsb pdb:2LQC|rcsb pdb:3G43|rcsb pdb:3OXQ|rcsb pdb:5V2P|rcsb pdb:5V2Q|rcsb pdb:6C0A|rcsb pdb:6DAD|rcsb pdb:6DAE|rcsb pdb:6DAF|rcsb pdb:6U39|rcsb pdb:6U3A|rcsb pdb:6U3B|rcsb pdb:6U3D|go:"GO:0070588"(calcium ion transmembrane transport)|reactome:R-HSA-5576892|dip:DIP-29589N	refseq:NP_001273445.1|refseq:NP_001128582.1|refseq:NP_005138.3|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060336"(negative regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0071340"(skeletal muscle acetylcholine-gated channel clustering)|go:"GO:0106137"(IkappaB kinase complex binding)|interpro:IPR001305(Heat shock protein DnaJ, cysteine-rich region)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR008971(HSP40/DnaJ peptide-binding)|interpro:IPR012724(Chaperone DnaJ)|interpro:IPR018253|interpro:IPR036410|interpro:IPR036869|mint:Q96EY1|rcsb pdb:2CTT|rcsb pdb:2DN9|rcsb pdb:6IWS|ensembl:ENSG00000103423(gene)|ensembl:ENSG00000276726(gene)|ensembl:ENST00000262375(transcript)|ensembl:ENST00000612103(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005133"(interferon-gamma receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006264"(mitochondrial DNA replication)|go:"GO:0006457"(protein folding)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006924"(activation-induced cell death of T cells)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0007569"(cell aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009408"(response to heat)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0030695"(GTPase regulator activity)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051059"(NF-kappaB binding)|dip:DIP-33870N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:dhWcWUTulWYd/nQtGorjr481/XA9606	rogid:WnRYdQ9E3yGbSlq1SSGTX9k+3uA9606	rigid:cieJ6vxRlSKvgU8sCIivij7QMeE	false	sufficient binding region:1841-2221	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q96QS3	uniprotkb:P14618	intact:EBI-11107474|ensembl:ENSP00000368332	intact:EBI-353408|uniprotkb:A6NFK3|uniprotkb:P14786|uniprotkb:Q53GK4|uniprotkb:Q96E76|uniprotkb:Q9BWB5|uniprotkb:Q9UPF2|uniprotkb:B2R5N8|uniprotkb:B3KRY0|uniprotkb:B4DFX8|uniprotkb:Q9UCV6|intact:EBI-2555890|uniprotkb:B4DUU6|ensembl:ENSP00000334983	psi-mi:arx_human(display_long)|uniprotkb:ARX(gene name)|psi-mi:ARX(display_short)|uniprotkb:Aristaless-related homeobox(gene name synonym)	psi-mi:kpym_human(display_long)|uniprotkb:PKM(gene name)|psi-mi:PKM(display_short)|uniprotkb:Cytosolic thyroid hormone-binding protein(gene name synonym)|uniprotkb:OIP3(gene name synonym)|uniprotkb:Opa-interacting protein 3(gene name synonym)|uniprotkb:PK2(gene name synonym)|uniprotkb:PK3(gene name synonym)|uniprotkb:PKM2(gene name synonym)|uniprotkb:Pyruvate kinase 2/3(gene name synonym)|uniprotkb:Pyruvate kinase muscle isozyme(gene name synonym)|uniprotkb:Thyroid hormone-binding protein 1(gene name synonym)|uniprotkb:Tumor M2-PK(gene name synonym)|uniprotkb:p58(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26508889|imex:IM-28561-1335	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_620689.1|ensembl:ENSG00000004848(gene)|ensembl:ENST00000379044(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007411"(axon guidance)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0021759"(globus pallidus development)|go:"GO:0021800"(cerebral cortex tangential migration)|go:"GO:0021831"(embryonic olfactory bulb interneuron precursor migration)|go:"GO:0021846"(cell proliferation in forebrain)|go:"GO:0021853"(cerebral cortex GABAergic interneuron migration)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0044241"(lipid digestion)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0048484"(enteric nervous system development)|go:"GO:0072148"(epithelial cell fate commitment)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR003654(Paired-like homeodomain protein, OAR)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970	refseq:NP_001193725.1|refseq:NP_001193727.1|refseq:NP_001193728.1|refseq:NP_002645.3|refseq:NP_872270.1|refseq:NP_872271.1|refseq:NP_001193726.1|refseq:NP_001303247.1|refseq:XP_005254502.1|dip:DIP-31273N|ensembl:ENSG00000067225(gene)|ensembl:ENST00000335181(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004743"(pyruvate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0006096"(glycolytic process)|go:"GO:0012501"(programmed cell death)|go:"GO:0016301"(kinase activity)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031982"(vesicle)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0045296"(cadherin binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2000767"(positive regulation of cytoplasmic translation)|interpro:IPR001697(Pyruvate kinase)|interpro:IPR011037(Pyruvate kinase, beta-barrel-like)|interpro:IPR015793(Pyruvate kinase, barrel)|interpro:IPR015795(Pyruvate kinase, C-terminal-like)|interpro:IPR015806(Pyruvate kinase, beta-barrel)|interpro:IPR015813(Pyruvate/Phosphoenolpyruvate kinase, catalytic core)|interpro:IPR018209|interpro:IPR036918|interpro:IPR040442|mint:P14618|rcsb pdb:1T5A|rcsb pdb:1ZJH|rcsb pdb:3BJF|rcsb pdb:3BJT|rcsb pdb:3G2G|rcsb pdb:3GQY|rcsb pdb:3GR4|rcsb pdb:3H6O|rcsb pdb:3ME3|rcsb pdb:3SRD|rcsb pdb:3SRF|rcsb pdb:3U2Z|rcsb pdb:4B2D|rcsb pdb:4FXF|rcsb pdb:4FXJ|rcsb pdb:4G1N|rcsb pdb:4JPG|rcsb pdb:4QG6|rcsb pdb:4QG8|rcsb pdb:4QG9|rcsb pdb:4QGC|rcsb pdb:4RPP|rcsb pdb:4WJ8|rcsb pdb:4YJ5|rcsb pdb:5X0I|rcsb pdb:5X1V|rcsb pdb:5X1W|rcsb pdb:6B6U|rcsb pdb:6GG3|rcsb pdb:6GG4|rcsb pdb:6GG5|rcsb pdb:6GG6|rcsb pdb:6JFB|rcsb pdb:6NU1|rcsb pdb:6NU5|rcsb pdb:6NUB|rcsb pdb:6TTF|rcsb pdb:6TTH|rcsb pdb:6TTI|rcsb pdb:6TTQ|rcsb pdb:6V74|rcsb pdb:3SRH|rcsb pdb:6V75|rcsb pdb:6V76|rcsb pdb:6WP3|rcsb pdb:6WP4|rcsb pdb:6WP5|rcsb pdb:6WP6|reactome:R-HSA-6798695|reactome:R-HSA-70171|refseq:XP_016877802.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:rBLZYkByOhAZEXEvFVmWxRB3oN09606	rogid:dDaoXCaqd0x6qFSElvngHusttuk9606	rigid:2iGrot1zV3W7ptrHioonl33ieIw	false	sufficient binding region:385-562,1-261	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q96QS3	uniprotkb:Q9NRD5	intact:EBI-11107474|ensembl:ENSP00000368332	intact:EBI-79165|uniprotkb:O95906|ensembl:ENSP00000349465|ensembl:ENSP00000385205|intact:EBI-2622151|uniprotkb:B3KS52	psi-mi:arx_human(display_long)|uniprotkb:ARX(gene name)|psi-mi:ARX(display_short)|uniprotkb:Aristaless-related homeobox(gene name synonym)	psi-mi:pick1_human(display_long)|uniprotkb:PICK1(gene name)|psi-mi:PICK1(display_short)|uniprotkb:PRKCABP(gene name synonym)|uniprotkb:Protein kinase C-alpha-binding protein(gene name synonym)|uniprotkb:Protein interacting with C kinase 1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26508880|imex:IM-28561-1553	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_620689.1|ensembl:ENSG00000004848(gene)|ensembl:ENST00000379044(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007411"(axon guidance)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0021759"(globus pallidus development)|go:"GO:0021800"(cerebral cortex tangential migration)|go:"GO:0021831"(embryonic olfactory bulb interneuron precursor migration)|go:"GO:0021846"(cell proliferation in forebrain)|go:"GO:0021853"(cerebral cortex GABAergic interneuron migration)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0044241"(lipid digestion)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0048484"(enteric nervous system development)|go:"GO:0072148"(epithelial cell fate commitment)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR003654(Paired-like homeodomain protein, OAR)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970	ensembl:ENSG00000100151(gene)|ensembl:ENST00000356976(transcript)|ensembl:ENST00000404072(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|refseq:NP_001034672.1|refseq:NP_001034673.1|refseq:NP_036539.1|go:"GO:0015844"(monoamine transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021782"(glial cell development)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0034315"(regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0034316"(negative regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0036294"(cellular response to decreased oxygen levels)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0043113"(receptor clustering)|go:"GO:0045161"(neuronal ion channel clustering)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051015"(actin filament binding)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0098842"(postsynaptic early endosome)|go:"GO:0140090"(membrane curvature sensor activity)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR010504(Arfaptin-like)|interpro:IPR027267|interpro:IPR030798|interpro:IPR036034|interpro:IPR037959|mint:Q9NRD5|rcsb pdb:2GZV|rcsb pdb:6AR4|rcsb pdb:6BJN|rcsb pdb:6BJO|reactome:R-HSA-202733|reactome:R-HSA-416993	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:rBLZYkByOhAZEXEvFVmWxRB3oN09606	rogid:qRx+eNG7We8Oe0SQOekqpJpn8zk9606	rigid:aP6cWlqNDTXLBAo+WC60J/aLa3U	false	sufficient binding region:1-261	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q96QS3	uniprotkb:Q99435	intact:EBI-11107474|ensembl:ENSP00000368332	intact:EBI-946274|intact:EBI-2845314|uniprotkb:B7Z2U7|uniprotkb:B7Z5Q4|uniprotkb:B7Z9J5|uniprotkb:B7Z9U3|uniprotkb:Q96JS2|ensembl:ENSP00000390680|ensembl:ENSP00000394612	psi-mi:arx_human(display_long)|uniprotkb:ARX(gene name)|psi-mi:ARX(display_short)|uniprotkb:Aristaless-related homeobox(gene name synonym)	psi-mi:nell2_human(display_long)|uniprotkb:NELL2(gene name)|psi-mi:NELL2(display_short)|uniprotkb:NRP2(gene name synonym)|uniprotkb:NEL-like protein 2(gene name synonym)|uniprotkb:Nel-related protein 2(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26508873|imex:IM-28561-209	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_620689.1|ensembl:ENSG00000004848(gene)|ensembl:ENST00000379044(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007411"(axon guidance)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0021759"(globus pallidus development)|go:"GO:0021800"(cerebral cortex tangential migration)|go:"GO:0021831"(embryonic olfactory bulb interneuron precursor migration)|go:"GO:0021846"(cell proliferation in forebrain)|go:"GO:0021853"(cerebral cortex GABAergic interneuron migration)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0044241"(lipid digestion)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0048484"(enteric nervous system development)|go:"GO:0072148"(epithelial cell fate commitment)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR003654(Paired-like homeodomain protein, OAR)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970	refseq:NP_001138579.1|refseq:NP_001138580.1|refseq:NP_001138581.1|refseq:NP_001138582.1|refseq:NP_006150.1|refseq:XP_011536698.1|refseq:XP_005268962.1|dip:DIP-49927N|ensembl:ENSG00000184613(gene)|ensembl:ENST00000429094(transcript)|ensembl:ENST00000452445(transcript)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0008201"(heparin binding)|go:"GO:0070050"(neuron cellular homeostasis)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR001791(Laminin G)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR018097|mint:Q99435|rcsb pdb:6POG|reactome:R-HSA-428542	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:rBLZYkByOhAZEXEvFVmWxRB3oN09606	rogid:/NYlmX9iC3H17WXd+u97CVwOD7c9606	rigid:kxEU45mnjPoHyetyFKlMDKZTXIg	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q13936	uniprotkb:Q14192	intact:EBI-1038838|uniprotkb:Q13917|uniprotkb:Q13918|uniprotkb:Q13919|uniprotkb:Q13920|uniprotkb:Q13921|uniprotkb:Q13922|uniprotkb:Q13923|uniprotkb:Q13924|uniprotkb:Q13925|uniprotkb:Q13926|uniprotkb:Q13927|uniprotkb:Q13928|uniprotkb:Q13929|uniprotkb:Q13930|uniprotkb:Q13932|uniprotkb:Q13933|uniprotkb:Q14743|uniprotkb:Q14744|uniprotkb:Q15877|uniprotkb:Q4VMI7|uniprotkb:Q4VMI8|uniprotkb:Q4VMI9|uniprotkb:Q6PKM7|uniprotkb:Q8N6C0|uniprotkb:Q99025|uniprotkb:Q99241|uniprotkb:Q99875|uniprotkb:B2RUT3|uniprotkb:E9PDJ0	intact:EBI-701903|ensembl:ENSP00000322909|ensembl:ENSP00000344266|ensembl:ENSP00000377020|ensembl:ENSP00000377021|ensembl:ENSP00000386633|ensembl:ENSP00000386665|ensembl:ENSP00000386892|ensembl:ENSP00000433567|uniprotkb:Q13229|uniprotkb:Q13644|uniprotkb:Q9P294|uniprotkb:Q2I5I4|uniprotkb:Q5TM15	psi-mi:cac1c_human(display_long)|uniprotkb:CACNA1C(gene name)|psi-mi:CACNA1C(display_short)|uniprotkb:CACH2(gene name synonym)|uniprotkb:CACN2(gene name synonym)|uniprotkb:CACNL1A1(gene name synonym)|uniprotkb:CCHL1A1(gene name synonym)|uniprotkb:Voltage-gated calcium channel subunit alpha Cav1.2(gene name synonym)|uniprotkb:Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle(gene name synonym)	psi-mi:fhl2_human(display_long)|uniprotkb:Skeletal muscle LIM-protein 3(gene name synonym)|uniprotkb:LIM domain protein DRAL(gene name synonym)|uniprotkb:FHL2(gene name)|psi-mi:FHL2(display_short)|uniprotkb:DRAL(gene name synonym)|uniprotkb:SLIM3(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26508979|imex:IM-28561-1337	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000710.5|refseq:NP_001123299.1|refseq:NP_001123301.1|refseq:NP_001123303.1|refseq:NP_001123304.1|refseq:NP_001123305.1|refseq:NP_001123306.1|refseq:NP_001123307.1|refseq:NP_001123314.1|refseq:NP_001123315.1|refseq:NP_001123308.1|refseq:NP_001123309.1|refseq:NP_001123310.1|refseq:NP_001123311.1|refseq:NP_001123312.1|refseq:NP_001123313.1|refseq:NP_001123316.1|refseq:NP_001123318.1|refseq:NP_001161095.1|refseq:NP_001161097.1|refseq:NP_001123302.2|refseq:NP_001161096.2|refseq:NP_955630.3|reactome:R-HSA-5576893|reactome:R-HSA-400042|reactome:R-HSA-419037|reactome:R-HSA-422356|go:"GO:0002520"(immune system development)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007507"(heart development)|go:"GO:0008331"(high voltage-gated calcium channel activity)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030425"(dendrite)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035585"(calcium-mediated signaling using extracellular calcium source)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043204"(perikaryon)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0061337"(cardiac conduction)|go:"GO:0061577"(calcium ion transmembrane transport via high voltage-gated calcium channel)|go:"GO:0070509"(calcium ion import)|go:"GO:0086002"(cardiac muscle cell action potential involved in contraction)|go:"GO:0086007"(voltage-gated calcium channel activity involved in cardiac muscle cell action potential)|go:"GO:0086012"(membrane depolarization during cardiac muscle cell action potential)|go:"GO:0086045"(membrane depolarization during AV node cell action potential)|go:"GO:0086056"(voltage-gated calcium channel activity involved in AV node cell action potential)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|go:"GO:0098912"(membrane depolarization during atrial cardiac muscle cell action potential)|go:"GO:1990454"(L-type voltage-gated calcium channel complex)|interpro:IPR002077(Voltage-dependent calcium channel, alpha-1 subunit)|interpro:IPR005446(Voltage-dependent calcium channel, L-type, alpha-1 subunit)|interpro:IPR005451(Voltage-dependent calcium channel, L-type, alpha-1C subunit)|interpro:IPR005821(Ion transport)|interpro:IPR014873(Voltage-dependent calcium channel, alpha-1 subunit, IQ domain)|interpro:IPR027359|interpro:IPR031649|interpro:IPR031688|rcsb pdb:1T0J|rcsb pdb:2BE6|rcsb pdb:2F3Y|rcsb pdb:2F3Z|rcsb pdb:2LQC|rcsb pdb:3G43|rcsb pdb:3OXQ|rcsb pdb:5V2P|rcsb pdb:5V2Q|rcsb pdb:6C0A|rcsb pdb:6DAD|rcsb pdb:6DAE|rcsb pdb:6DAF|rcsb pdb:6U39|rcsb pdb:6U3A|rcsb pdb:6U3B|rcsb pdb:6U3D|go:"GO:0070588"(calcium ion transmembrane transport)|reactome:R-HSA-5576892|dip:DIP-29589N	ensembl:ENSG00000115641(gene)|ensembl:ENST00000322142(transcript)|ensembl:ENST00000344213(transcript)|ensembl:ENST00000393352(transcript)|ensembl:ENST00000393353(transcript)|ensembl:ENST00000408995(transcript)|ensembl:ENST00000409177(transcript)|ensembl:ENST00000409807(transcript)|ensembl:ENST00000530340(transcript)|refseq:NP_001034581.1|refseq:NP_001441.4|refseq:NP_963849.1|refseq:NP_963851.2|refseq:NP_001305823.1|refseq:NP_001305824.1|refseq:NP_001305825.1|refseq:NP_001305826.1|refseq:XP_011509100.1|dip:DIP-5980N|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009725"(response to hormone)|go:"GO:0030018"(Z disc)|go:"GO:0031430"(M band)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0055014"(atrial cardiac muscle cell development)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0060347"(heart trabecula formation)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR037987|mint:Q14192|rcsb pdb:1X4K|rcsb pdb:1X4L|rcsb pdb:2D8Z|rcsb pdb:2MIU|reactome:R-HSA-1989781	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:dhWcWUTulWYd/nQtGorjr481/XA9606	rogid:4X5kI037ASzuT1zACXH89BkwDBk9606	rigid:1FwV+MZkePanqrvmXgXI+Jpa1ac	false	sufficient binding region:1841-2221	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q13936	uniprotkb:Q12805	intact:EBI-1038838|uniprotkb:Q13917|uniprotkb:Q13918|uniprotkb:Q13919|uniprotkb:Q13920|uniprotkb:Q13921|uniprotkb:Q13922|uniprotkb:Q13923|uniprotkb:Q13924|uniprotkb:Q13925|uniprotkb:Q13926|uniprotkb:Q13927|uniprotkb:Q13928|uniprotkb:Q13929|uniprotkb:Q13930|uniprotkb:Q13932|uniprotkb:Q13933|uniprotkb:Q14743|uniprotkb:Q14744|uniprotkb:Q15877|uniprotkb:Q4VMI7|uniprotkb:Q4VMI8|uniprotkb:Q4VMI9|uniprotkb:Q6PKM7|uniprotkb:Q8N6C0|uniprotkb:Q99025|uniprotkb:Q99241|uniprotkb:Q99875|uniprotkb:B2RUT3|uniprotkb:E9PDJ0	intact:EBI-536772|uniprotkb:Q541U7|uniprotkb:A8K3I4|uniprotkb:D6W5D2|ensembl:ENSP00000347596|ensembl:ENSP00000378058|uniprotkb:B4DW75	psi-mi:cac1c_human(display_long)|uniprotkb:CACNA1C(gene name)|psi-mi:CACNA1C(display_short)|uniprotkb:CACH2(gene name synonym)|uniprotkb:CACN2(gene name synonym)|uniprotkb:CACNL1A1(gene name synonym)|uniprotkb:CCHL1A1(gene name synonym)|uniprotkb:Voltage-gated calcium channel subunit alpha Cav1.2(gene name synonym)|uniprotkb:Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle(gene name synonym)	psi-mi:fbln3_human(display_long)|uniprotkb:Fibulin-3(gene name synonym)|uniprotkb:Fibrillin-like protein(gene name synonym)|uniprotkb:Extracellular protein S1-5(gene name synonym)|uniprotkb:EFEMP1(gene name)|psi-mi:EFEMP1(display_short)|uniprotkb:FBLN3(gene name synonym)|uniprotkb:FBNL(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26508970|imex:IM-28561-871	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000710.5|refseq:NP_001123299.1|refseq:NP_001123301.1|refseq:NP_001123303.1|refseq:NP_001123304.1|refseq:NP_001123305.1|refseq:NP_001123306.1|refseq:NP_001123307.1|refseq:NP_001123314.1|refseq:NP_001123315.1|refseq:NP_001123308.1|refseq:NP_001123309.1|refseq:NP_001123310.1|refseq:NP_001123311.1|refseq:NP_001123312.1|refseq:NP_001123313.1|refseq:NP_001123316.1|refseq:NP_001123318.1|refseq:NP_001161095.1|refseq:NP_001161097.1|refseq:NP_001123302.2|refseq:NP_001161096.2|refseq:NP_955630.3|reactome:R-HSA-5576893|reactome:R-HSA-400042|reactome:R-HSA-419037|reactome:R-HSA-422356|go:"GO:0002520"(immune system development)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007507"(heart development)|go:"GO:0008331"(high voltage-gated calcium channel activity)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030425"(dendrite)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035585"(calcium-mediated signaling using extracellular calcium source)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043204"(perikaryon)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0061337"(cardiac conduction)|go:"GO:0061577"(calcium ion transmembrane transport via high voltage-gated calcium channel)|go:"GO:0070509"(calcium ion import)|go:"GO:0086002"(cardiac muscle cell action potential involved in contraction)|go:"GO:0086007"(voltage-gated calcium channel activity involved in cardiac muscle cell action potential)|go:"GO:0086012"(membrane depolarization during cardiac muscle cell action potential)|go:"GO:0086045"(membrane depolarization during AV node cell action potential)|go:"GO:0086056"(voltage-gated calcium channel activity involved in AV node cell action potential)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|go:"GO:0098912"(membrane depolarization during atrial cardiac muscle cell action potential)|go:"GO:1990454"(L-type voltage-gated calcium channel complex)|interpro:IPR002077(Voltage-dependent calcium channel, alpha-1 subunit)|interpro:IPR005446(Voltage-dependent calcium channel, L-type, alpha-1 subunit)|interpro:IPR005451(Voltage-dependent calcium channel, L-type, alpha-1C subunit)|interpro:IPR005821(Ion transport)|interpro:IPR014873(Voltage-dependent calcium channel, alpha-1 subunit, IQ domain)|interpro:IPR027359|interpro:IPR031649|interpro:IPR031688|rcsb pdb:1T0J|rcsb pdb:2BE6|rcsb pdb:2F3Y|rcsb pdb:2F3Z|rcsb pdb:2LQC|rcsb pdb:3G43|rcsb pdb:3OXQ|rcsb pdb:5V2P|rcsb pdb:5V2Q|rcsb pdb:6C0A|rcsb pdb:6DAD|rcsb pdb:6DAE|rcsb pdb:6DAF|rcsb pdb:6U39|rcsb pdb:6U3A|rcsb pdb:6U3B|rcsb pdb:6U3D|go:"GO:0070588"(calcium ion transmembrane transport)|reactome:R-HSA-5576892|dip:DIP-29589N	ensembl:ENSG00000115380(gene)|ensembl:ENST00000355426(transcript)|ensembl:ENST00000394555(transcript)|go:"GO:0005006"(epidermal growth factor-activated receptor activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007601"(visual perception)|go:"GO:0008083"(growth factor activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0043010"(camera-type eye development)|go:"GO:0048048"(embryonic eye morphogenesis)|go:"GO:0048050"(post-embryonic eye morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR018097|interpro:IPR026823|interpro:IPR032973|mint:Q12805|reactome:R-HSA-2129379|refseq:NP_001034437.1|refseq:NP_001034438.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:dhWcWUTulWYd/nQtGorjr481/XA9606	rogid:V32dS+EEp5Syu3A6lQJal0fg6UM9606	rigid:nTli/+ca4DMl86R/3TrIxNbPoic	false	sufficient binding region:1841-2221	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q96QS3	uniprotkb:Q9BYW2	intact:EBI-11107474|ensembl:ENSP00000368332	intact:EBI-945869|uniprotkb:O75397|uniprotkb:O75405|uniprotkb:Q17RW8|uniprotkb:Q5BKS9|uniprotkb:Q5QGN2|uniprotkb:Q69YI5|uniprotkb:Q6IN64|uniprotkb:Q6ZN53|uniprotkb:Q6ZS25|uniprotkb:Q8N3R0|uniprotkb:Q8TCN0|uniprotkb:Q9C0D1|uniprotkb:Q9H696|uniprotkb:Q9NZW9|ensembl:ENSP00000386759	psi-mi:arx_human(display_long)|uniprotkb:ARX(gene name)|psi-mi:ARX(display_short)|uniprotkb:Aristaless-related homeobox(gene name synonym)	psi-mi:setd2_human(display_long)|uniprotkb:Protein-lysine N-methyltransferase SETD2(gene name synonym)|uniprotkb:KMT3A(gene name synonym)|uniprotkb:SET domain-containing protein 2(gene name synonym)|uniprotkb:Huntingtin-interacting protein B(gene name synonym)|uniprotkb:Huntingtin yeast partner B(gene name synonym)|uniprotkb:Huntingtin-interacting protein 1(gene name synonym)|uniprotkb:HIF-1(gene name synonym)|uniprotkb:p231HBP(gene name synonym)|uniprotkb:Lysine N-methyltransferase 3A(gene name synonym)|uniprotkb:SETD2(gene name)|psi-mi:SETD2(display_short)|uniprotkb:HIF1(gene name synonym)|uniprotkb:HYPB(gene name synonym)|uniprotkb:KIAA1732(gene name synonym)|uniprotkb:SET2(gene name synonym)|uniprotkb:HSPC069(orf name)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26508898|imex:IM-28561-211	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_620689.1|ensembl:ENSG00000004848(gene)|ensembl:ENST00000379044(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007411"(axon guidance)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0021759"(globus pallidus development)|go:"GO:0021800"(cerebral cortex tangential migration)|go:"GO:0021831"(embryonic olfactory bulb interneuron precursor migration)|go:"GO:0021846"(cell proliferation in forebrain)|go:"GO:0021853"(cerebral cortex GABAergic interneuron migration)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0044241"(lipid digestion)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0048484"(enteric nervous system development)|go:"GO:0072148"(epithelial cell fate commitment)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR003654(Paired-like homeodomain protein, OAR)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970	refseq:NP_054878.5|ensembl:ENSG00000181555(gene)|ensembl:ENST00000409792(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001763"(morphogenesis of a branching structure)|go:"GO:0001843"(neural tube closure)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006298"(mismatch repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0010569"(regulation of double-strand break repair via homologous recombination)|go:"GO:0010793"(regulation of mRNA export from nucleus)|go:"GO:0016279"(protein-lysine N-methyltransferase activity)|go:"GO:0018023"(peptidyl-lysine trimethylation)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0018026"(peptidyl-lysine monomethylation)|go:"GO:0030900"(forebrain development)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0034340"(response to type I interferon)|go:"GO:0034728"(nucleosome organization)|go:"GO:0035441"(cell migration involved in vasculogenesis)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0046975"("histone methyltransferase activity (H3-K36 specific)")|go:"GO:0048332"(mesoderm morphogenesis)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0048864"(stem cell development)|go:"GO:0051607"(defense response to virus)|go:"GO:0060039"(pericardium development)|go:"GO:0060669"(embryonic placenta morphogenesis)|go:"GO:0060977"(coronary vasculature morphogenesis)|go:"GO:0097198"(histone H3-K36 trimethylation)|go:"GO:0097676"(histone H3-K36 dimethylation)|go:"GO:1902850"(microtubule cytoskeleton organization involved in mitosis)|go:"GO:1905634"(regulation of protein localization to chromatin)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001214(SET)|interpro:IPR003616(Post-SET zinc-binding region)|interpro:IPR006560(AWS)|interpro:IPR013257(SRI, Set2 Rpb1 interacting)|interpro:IPR035441|interpro:IPR036020|interpro:IPR038190|interpro:IPR042294|interpro:IPR044437|mint:Q9BYW2|rcsb pdb:2A7O|rcsb pdb:2MDC|rcsb pdb:2MDI|rcsb pdb:2MDJ|rcsb pdb:4FMU|rcsb pdb:4H12|rcsb pdb:5JJY|rcsb pdb:5JLB|rcsb pdb:5JLE|rcsb pdb:5LSS|rcsb pdb:5LSX|rcsb pdb:5LSY|rcsb pdb:5LSZ|rcsb pdb:5LT6|rcsb pdb:5LT7|rcsb pdb:5LT8|rcsb pdb:5V21|rcsb pdb:5V22|rcsb pdb:6J9J|rcsb pdb:6VDB|reactome:R-HSA-3214841	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:rBLZYkByOhAZEXEvFVmWxRB3oN09606	rogid:9f0NjyLj+lCSDh5yRP9lVMMepuw9606	rigid:txAnWyUYKWDRDxtVAGb/j28Xd20	false	sufficient binding region:1-261	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P78352	uniprotkb:P10909	intact:EBI-80389|ensembl:ENSP00000382425|intact:EBI-1760259|uniprotkb:Q92941|uniprotkb:Q9UKK8|intact:EBI-1965339|uniprotkb:B7Z1S1|uniprotkb:G5E939	intact:EBI-1104674|uniprotkb:B3KSE6|uniprotkb:P11380|uniprotkb:P11381|uniprotkb:Q5HYC1|uniprotkb:Q7Z5B9|uniprotkb:B2R9Q1|uniprotkb:Q2TU75|ensembl:ENSP00000315130|ensembl:ENSP00000385419|ensembl:ENSP00000429620	psi-mi:dlg4_human(display_long)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)|uniprotkb:DLG4(gene name)|psi-mi:DLG4(display_short)|uniprotkb:PSD95(gene name synonym)	psi-mi:clus_human(display_long)|uniprotkb:CLU(gene name)|psi-mi:CLU(display_short)|uniprotkb:APOJ(gene name synonym)|uniprotkb:CLI(gene name synonym)|uniprotkb:KUB1(gene name synonym)|uniprotkb:Complement-associated protein SP-40,40(gene name synonym)|uniprotkb:Complement cytolysis inhibitor(gene name synonym)|uniprotkb:NA1/NA2(gene name synonym)|uniprotkb:Apolipoprotein J(gene name synonym)|uniprotkb:Testosterone-repressed prostate message 2(gene name synonym)|uniprotkb:Ku70-binding protein 1(gene name synonym)|uniprotkb:Aging-associated gene 4 protein(gene name synonym)|uniprotkb:AAG4(orf name)|uniprotkb:Sulfated glycoprotein 2(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509146|imex:IM-28561-663	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000132535(gene)|ensembl:ENST00000399506(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007399"(nervous system development)|go:"GO:0007612"(learning)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019900"(kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:P78352|rcsb pdb:1KEF|rcsb pdb:2MES|rcsb pdb:3I4W|rcsb pdb:3K82|rcsb pdb:3ZRT|rcsb pdb:5J7J|rcsb pdb:5JXB|rcsb pdb:6QJD|rcsb pdb:6QJF|rcsb pdb:6QJG|rcsb pdb:6QJI|rcsb pdb:6QJJ|rcsb pdb:6QJK|rcsb pdb:6QJL|rcsb pdb:6QJN|rcsb pdb:6SPV|rcsb pdb:6SPZ|reactome:R-HSA-1236394|reactome:R-HSA-399719|reactome:R-HSA-438066|reactome:R-HSA-442982|reactome:R-HSA-447038|reactome:R-HSA-451308|reactome:R-HSA-5673001|reactome:R-HSA-5682910|reactome:R-HSA-6794361|reactome:R-HSA-8849932|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-5625900|reactome:R-HSA-9620244|refseq:NP_001308004.1|refseq:NP_001356.1|refseq:NP_001122299.1|dip:DIP-30919N	go:"GO:0006629"(lipid metabolic process)|go:"GO:0006956"(complement activation)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0009615"(response to virus)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0017038"(protein import)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032286"(central nervous system myelin maintenance)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0005829"(cytosol)|ensembl:ENSG00000120885(gene)|ensembl:ENST00000316403(transcript)|ensembl:ENST00000405140(transcript)|ensembl:ENST00000523500(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0002434"(immune complex clearance)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0034366"(spherical high-density lipoprotein particle)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042583"(chromaffin granule)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043691"(reverse cholesterol transport)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045202"(synapse)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048156"(tau protein binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0051788"(response to misfolded protein)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:0061740"(protein targeting to lysosome involved in chaperone-mediated autophagy)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0097418"(neurofibrillary tangle)|go:"GO:0097440"(apical dendrite)|go:"GO:0099020"(perinuclear endoplasmic reticulum lumen)|go:"GO:0140597"(protein carrier chaperone)|go:"GO:1900221"(regulation of amyloid-beta clearance)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902847"(regulation of neuronal signal transduction)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1902998"(positive regulation of neurofibrillary tangle assembly)|go:"GO:1903573"(negative regulation of response to endoplasmic reticulum stress)|go:"GO:1905892"(negative regulation of cellular response to thapsigargin)|go:"GO:1905895"(negative regulation of cellular response to tunicamycin)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:1905908"(positive regulation of amyloid fibril formation)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000753(Clusterin-like)|interpro:IPR016014(Clusterin, N-terminal)|interpro:IPR016015(Clusterin, C-terminal)|interpro:IPR016016(Clusterin)|interpro:IPR033986|mint:P10909|reactome:R-HSA-114608|reactome:R-HSA-166665|reactome:R-HSA-6803157|go:"GO:0060548"(negative regulation of cell death)|reactome:R-HSA-977606|refseq:NP_001822.3|dip:DIP-37546N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:VhIVoWngQFYTjco3EzG0If9uh+Y9606	rogid:qlCJp4zYTklC3YZNQvbLmZBiz4U9606	rigid:1kSXn8AXQGq21qlqNb8ghFDZM+U	false	sufficient binding region:546-724	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P78352	uniprotkb:Q15700	intact:EBI-80389|ensembl:ENSP00000382425|intact:EBI-1760259|uniprotkb:Q92941|uniprotkb:Q9UKK8|intact:EBI-1965339|uniprotkb:B7Z1S1|uniprotkb:G5E939	intact:EBI-80426|ensembl:ENSP00000381355|uniprotkb:Q59G57|uniprotkb:Q68CQ8|uniprotkb:Q6ZTA8|uniprotkb:B7WNY8|uniprotkb:F8W9V6|uniprotkb:Q5H9Q4	psi-mi:dlg4_human(display_long)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)|uniprotkb:DLG4(gene name)|psi-mi:DLG4(display_short)|uniprotkb:PSD95(gene name synonym)	psi-mi:dlg2_human(display_long)|uniprotkb:DLG2(gene name)|psi-mi:DLG2(display_short)|uniprotkb:Postsynaptic density protein PSD-93(gene name synonym)|uniprotkb:Channel-associated protein of synapse-110(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509155|imex:IM-28561-921	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000132535(gene)|ensembl:ENST00000399506(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007399"(nervous system development)|go:"GO:0007612"(learning)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019900"(kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:P78352|rcsb pdb:1KEF|rcsb pdb:2MES|rcsb pdb:3I4W|rcsb pdb:3K82|rcsb pdb:3ZRT|rcsb pdb:5J7J|rcsb pdb:5JXB|rcsb pdb:6QJD|rcsb pdb:6QJF|rcsb pdb:6QJG|rcsb pdb:6QJI|rcsb pdb:6QJJ|rcsb pdb:6QJK|rcsb pdb:6QJL|rcsb pdb:6QJN|rcsb pdb:6SPV|rcsb pdb:6SPZ|reactome:R-HSA-1236394|reactome:R-HSA-399719|reactome:R-HSA-438066|reactome:R-HSA-442982|reactome:R-HSA-447038|reactome:R-HSA-451308|reactome:R-HSA-5673001|reactome:R-HSA-5682910|reactome:R-HSA-6794361|reactome:R-HSA-8849932|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-5625900|reactome:R-HSA-9620244|refseq:NP_001308004.1|refseq:NP_001356.1|refseq:NP_001122299.1|dip:DIP-30919N	ensembl:ENSG00000150672(gene)|ensembl:ENST00000398309(transcript)|go:"GO:0004385"(guanylate kinase activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019900"(kinase binding)|go:"GO:0030054"(cell junction)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043204"(perikaryon)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:0099642"(retrograde axonal protein transport)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|interpro:IPR008144(Guanylate kinase)|rcsb pdb:2BYG|rcsb pdb:2HE2|reactome:R-HSA-438066|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|reactome:R-HSA-442982|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|reactome:R-HSA-5673001|reactome:R-HSA-6794361|interpro:IPR035759|reactome:R-HSA-9609736|reactome:R-HSA-9617324|interpro:IPR036028|reactome:R-HSA-9620244|refseq:NP_001355.2|refseq:NP_001136171.1|refseq:NP_001136172.1|refseq:NP_001136174.1|refseq:NP_001193698.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:VhIVoWngQFYTjco3EzG0If9uh+Y9606	rogid:hBuRCYIzH2etGCJINoeHIYFGTrc9606	rigid:gVWJKS1+YATOXLDMhl3AiiSd3dI	false	sufficient binding region:298-550	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9GZU7	uniprotkb:Q5VT52	intact:EBI-751587|uniprotkb:Q7Z5Q3|uniprotkb:Q7Z5Q4|uniprotkb:C9IYG0|ensembl:ENSP00000273062	intact:EBI-372367|uniprotkb:O75048|uniprotkb:Q5VT53|uniprotkb:Q6MZL4|uniprotkb:Q86XD2|uniprotkb:A8K6N8|uniprotkb:B3KPT1|uniprotkb:Q5VT51|uniprotkb:Q9P0D7|uniprotkb:B4E2Q6|ensembl:ENSP00000358064	psi-mi:ctds1_human(display_long)|uniprotkb:SCP1(gene name synonym)|uniprotkb:Nuclear LIM interactor-interacting factor 3(gene name synonym)|uniprotkb:CTDSP1(gene name)|psi-mi:CTDSP1(display_short)|uniprotkb:NIF3(gene name synonym)|uniprotkb:NLIIF(gene name synonym)|uniprotkb:Small C-terminal domain phosphatase 1(gene name synonym)	psi-mi:rprd2_human(display_long)|uniprotkb:RPRD2(gene name)|psi-mi:RPRD2(display_short)|uniprotkb:KIAA0460(gene name synonym)|uniprotkb:HSPC099(orf name)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509114|imex:IM-28561-1573	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001193807.1|refseq:NP_067021.1|refseq:NP_872580.1|dip:DIP-61246N|ensembl:ENSG00000144579(gene)|ensembl:ENST00000273062(transcript)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008420"(RNA polymerase II CTD heptapeptide repeat phosphatase activity)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR004274(NLI interacting factor)|interpro:IPR011948(Dullard-like phosphatase domain)|interpro:IPR023214|interpro:IPR036412|interpro:IPR040078|mint:Q9GZU7|rcsb pdb:1T9Z|rcsb pdb:1TA0|rcsb pdb:2GHQ|rcsb pdb:2GHT|rcsb pdb:3L0B|rcsb pdb:3L0C|rcsb pdb:3L0Y|rcsb pdb:3PGL|rcsb pdb:4YGY|rcsb pdb:4YH1|rcsb pdb:6DU3	refseq:NP_056018.2|ensembl:ENSG00000163125(gene)|ensembl:ENST00000369068(transcript)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0016591"(RNA polymerase II, holoenzyme)|go:"GO:0031124"(mRNA 3'-end processing)|interpro:IPR006569(Regulation of nuclear pre-mRNA protein)|interpro:IPR008942(ENTH/VHS)|interpro:IPR032337|mint:Q5VT52|rcsb pdb:4FLB|reactome:R-HSA-6807505|refseq:NP_001284602.1|refseq:NP_001284603.1|dip:DIP-31155N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:V+4KyPU2ZkPO8pEuJapznDEnoVk9606	rogid:HbkwBBEJ+MNQOjJ2nezU7MJMHYQ9606	rigid:UcJ+kFRwRDSOFRYEHx/KhBo82YM	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P78352	uniprotkb:O60241	intact:EBI-80389|ensembl:ENSP00000382425|intact:EBI-1760259|uniprotkb:Q92941|uniprotkb:Q9UKK8|intact:EBI-1965339|uniprotkb:B7Z1S1|uniprotkb:G5E939	intact:EBI-465623|ensembl:ENSP00000362762|uniprotkb:Q5T6K0|uniprotkb:Q8NGW8|uniprotkb:B9EGK9|uniprotkb:Q96GZ9	psi-mi:dlg4_human(display_long)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)|uniprotkb:DLG4(gene name)|psi-mi:DLG4(display_short)|uniprotkb:PSD95(gene name synonym)	psi-mi:agrb2_human(display_long)|uniprotkb:ADGRB2(gene name)|psi-mi:ADGRB2(display_short)|uniprotkb:BAI2(gene name synonym)|uniprotkb:Brain-specific angiogenesis inhibitor 2(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509130|imex:IM-28561-427	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000132535(gene)|ensembl:ENST00000399506(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007399"(nervous system development)|go:"GO:0007612"(learning)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019900"(kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:P78352|rcsb pdb:1KEF|rcsb pdb:2MES|rcsb pdb:3I4W|rcsb pdb:3K82|rcsb pdb:3ZRT|rcsb pdb:5J7J|rcsb pdb:5JXB|rcsb pdb:6QJD|rcsb pdb:6QJF|rcsb pdb:6QJG|rcsb pdb:6QJI|rcsb pdb:6QJJ|rcsb pdb:6QJK|rcsb pdb:6QJL|rcsb pdb:6QJN|rcsb pdb:6SPV|rcsb pdb:6SPZ|reactome:R-HSA-1236394|reactome:R-HSA-399719|reactome:R-HSA-438066|reactome:R-HSA-442982|reactome:R-HSA-447038|reactome:R-HSA-451308|reactome:R-HSA-5673001|reactome:R-HSA-5682910|reactome:R-HSA-6794361|reactome:R-HSA-8849932|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-5625900|reactome:R-HSA-9620244|refseq:NP_001308004.1|refseq:NP_001356.1|refseq:NP_001122299.1|dip:DIP-30919N	refseq:NP_001281265.1|ensembl:ENSG00000121753(gene)|ensembl:ENST00000373658(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|interpro:IPR000203(GPS)|interpro:IPR000832(GPCR, family 2, secretin-like)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR001879(GPCR, family 2, extracellular region)|interpro:IPR008077(GPCR, family 2, brain-specific angiogenesis inhibitor)|interpro:IPR017981|interpro:IPR032471|interpro:IPR036383|interpro:IPR036445|interpro:IPR043838|go:"GO:0033173"(calcineurin-NFAT signaling cascade)|refseq:XP_016857388.1|refseq:XP_016857389.1|refseq:XP_016857394.1|refseq:NP_001281264.1|refseq:XP_011540150.1|refseq:XP_011540151.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:VhIVoWngQFYTjco3EzG0If9uh+Y9606	rogid:FxNDD5lilxe6W9bd/RXx7ht7HRk9606	rigid:PnDpPFM3TxJtCSl2X77fGMxSA7g	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P78352	uniprotkb:P35609	intact:EBI-80389|ensembl:ENSP00000382425|intact:EBI-1760259|uniprotkb:Q92941|uniprotkb:Q9UKK8|intact:EBI-1965339|uniprotkb:B7Z1S1|uniprotkb:G5E939	intact:EBI-77797|uniprotkb:Q86TF4|ensembl:ENSP00000355537|uniprotkb:Q86TI8|uniprotkb:B1ANE4|intact:EBI-928705|uniprotkb:B2RCS5	psi-mi:dlg4_human(display_long)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)|uniprotkb:DLG4(gene name)|psi-mi:DLG4(display_short)|uniprotkb:PSD95(gene name synonym)	psi-mi:actn2_human(display_long)|uniprotkb:ACTN2(gene name)|psi-mi:ACTN2(display_short)|uniprotkb:Alpha-actinin skeletal muscle isoform 2(gene name synonym)|uniprotkb:F-actin cross-linking protein(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509121|imex:IM-28561-217	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000132535(gene)|ensembl:ENST00000399506(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007399"(nervous system development)|go:"GO:0007612"(learning)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019900"(kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:P78352|rcsb pdb:1KEF|rcsb pdb:2MES|rcsb pdb:3I4W|rcsb pdb:3K82|rcsb pdb:3ZRT|rcsb pdb:5J7J|rcsb pdb:5JXB|rcsb pdb:6QJD|rcsb pdb:6QJF|rcsb pdb:6QJG|rcsb pdb:6QJI|rcsb pdb:6QJJ|rcsb pdb:6QJK|rcsb pdb:6QJL|rcsb pdb:6QJN|rcsb pdb:6SPV|rcsb pdb:6SPZ|reactome:R-HSA-1236394|reactome:R-HSA-399719|reactome:R-HSA-438066|reactome:R-HSA-442982|reactome:R-HSA-447038|reactome:R-HSA-451308|reactome:R-HSA-5673001|reactome:R-HSA-5682910|reactome:R-HSA-6794361|reactome:R-HSA-8849932|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-5625900|reactome:R-HSA-9620244|refseq:NP_001308004.1|refseq:NP_001356.1|refseq:NP_001122299.1|dip:DIP-30919N	refseq:NP_001094.1|ensembl:ENSG00000077522(gene)|ensembl:ENST00000366578(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005925"(focal adhesion)|go:"GO:0006936"(muscle contraction)|go:"GO:0007155"(cell adhesion)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030018"(Z disc)|go:"GO:0030035"(microspike assembly)|go:"GO:0030175"(filopodium)|go:"GO:0030274"(LIM domain binding)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031143"(pseudopodium)|go:"GO:0031432"(titin binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043267"(negative regulation of potassium ion transport)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045214"(sarcomere organization)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051015"(actin filament binding)|go:"GO:0051373"(FATZ binding)|go:"GO:0051695"(actin filament uncapping)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070080"(titin Z domain binding)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086097"(phospholipase C-activating angiotensin-activated signaling pathway)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|go:"GO:2001137"(positive regulation of endocytic recycling)|go:"GO:0030374"(nuclear receptor coactivator activity)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR036872|mint:P35609|rcsb pdb:1H8B|rcsb pdb:1HCI|rcsb pdb:1QUU|rcsb pdb:4D1E|rcsb pdb:5A36|rcsb pdb:5A37|rcsb pdb:5A38|rcsb pdb:5A4B|rcsb pdb:6SWT|rcsb pdb:6TS3|rcsb pdb:7A8T|rcsb pdb:7A8U|reactome:R-HSA-114608|go:"GO:2001259"(positive regulation of cation channel activity)|reactome:R-HSA-373753|reactome:R-HSA-390522|reactome:R-HSA-442982|reactome:R-HSA-5673001|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-9620244|reactome:R-HSA-438066|refseq:NP_001265272.1|refseq:NP_001265273.1|dip:DIP-383N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:VhIVoWngQFYTjco3EzG0If9uh+Y9606	rogid:9jws8DZxpttkzqPfDxEzORNnwcE9606	rigid:f6eBY7YLrctjIS9q58NmSAXNI/s	false	sufficient binding region:298-550	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9GZU7	uniprotkb:Q8ND90	intact:EBI-751587|uniprotkb:Q7Z5Q3|uniprotkb:Q7Z5Q4|uniprotkb:C9IYG0|ensembl:ENSP00000273062	intact:EBI-302345|uniprotkb:O95144|uniprotkb:Q8NG07|ensembl:ENSP00000318914|uniprotkb:A8K4L5	psi-mi:ctds1_human(display_long)|uniprotkb:SCP1(gene name synonym)|uniprotkb:Nuclear LIM interactor-interacting factor 3(gene name synonym)|uniprotkb:CTDSP1(gene name)|psi-mi:CTDSP1(display_short)|uniprotkb:NIF3(gene name synonym)|uniprotkb:NLIIF(gene name synonym)|uniprotkb:Small C-terminal domain phosphatase 1(gene name synonym)	psi-mi:pnma1_human(display_long)|uniprotkb:PNMA1(gene name)|psi-mi:PNMA1(display_short)|uniprotkb:MA1(gene name synonym)|uniprotkb:Neuron- and testis-specific protein 1(gene name synonym)|uniprotkb:37 kDa neuronal protein(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509107|imex:IM-28561-875	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001193807.1|refseq:NP_067021.1|refseq:NP_872580.1|dip:DIP-61246N|ensembl:ENSG00000144579(gene)|ensembl:ENST00000273062(transcript)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008420"(RNA polymerase II CTD heptapeptide repeat phosphatase activity)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR004274(NLI interacting factor)|interpro:IPR011948(Dullard-like phosphatase domain)|interpro:IPR023214|interpro:IPR036412|interpro:IPR040078|mint:Q9GZU7|rcsb pdb:1T9Z|rcsb pdb:1TA0|rcsb pdb:2GHQ|rcsb pdb:2GHT|rcsb pdb:3L0B|rcsb pdb:3L0C|rcsb pdb:3L0Y|rcsb pdb:3PGL|rcsb pdb:4YGY|rcsb pdb:4YH1|rcsb pdb:6DU3	refseq:NP_006020.4|ensembl:ENSG00000176903(gene)|ensembl:ENST00000316836(transcript)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0043065"(positive regulation of apoptotic process)|interpro:IPR026523|interpro:IPR026528|mint:Q8ND90	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:V+4KyPU2ZkPO8pEuJapznDEnoVk9606	rogid:/lx3CB7d/dv4xIgWQrCETPA0Qcw9606	rigid:+yVYuxqM93uKIi99BQWauBQ/QbQ	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9GZU7	uniprotkb:Q9Y4G2	intact:EBI-751587|uniprotkb:Q7Z5Q3|uniprotkb:Q7Z5Q4|uniprotkb:C9IYG0|ensembl:ENSP00000273062	intact:EBI-473814|uniprotkb:Q6P2R5|uniprotkb:Q8TEL9|uniprotkb:Q9NPP5|intact:EBI-715406|uniprotkb:Q9NYA0|ensembl:ENSP00000389913|ensembl:ENSP00000479066|ensembl:ENSP00000483820	psi-mi:ctds1_human(display_long)|uniprotkb:SCP1(gene name synonym)|uniprotkb:Nuclear LIM interactor-interacting factor 3(gene name synonym)|uniprotkb:CTDSP1(gene name)|psi-mi:CTDSP1(display_short)|uniprotkb:NIF3(gene name synonym)|uniprotkb:NLIIF(gene name synonym)|uniprotkb:Small C-terminal domain phosphatase 1(gene name synonym)	psi-mi:pkhm1_human(display_long)|uniprotkb:PLEKHM1(gene name)|psi-mi:PLEKHM1(display_short)|uniprotkb:KIAA0356(gene name synonym)|uniprotkb:162 kDa adapter protein(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509100|imex:IM-28561-1345	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001193807.1|refseq:NP_067021.1|refseq:NP_872580.1|dip:DIP-61246N|ensembl:ENSG00000144579(gene)|ensembl:ENST00000273062(transcript)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008420"(RNA polymerase II CTD heptapeptide repeat phosphatase activity)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR004274(NLI interacting factor)|interpro:IPR011948(Dullard-like phosphatase domain)|interpro:IPR023214|interpro:IPR036412|interpro:IPR040078|mint:Q9GZU7|rcsb pdb:1T9Z|rcsb pdb:1TA0|rcsb pdb:2GHQ|rcsb pdb:2GHT|rcsb pdb:3L0B|rcsb pdb:3L0C|rcsb pdb:3L0Y|rcsb pdb:3PGL|rcsb pdb:4YGY|rcsb pdb:4YH1|rcsb pdb:6DU3	refseq:NP_055613.1|refseq:XP_011523825.1|refseq:XP_011523826.1|refseq:XP_006722264.1|ensembl:ENSG00000225190(gene)|ensembl:ENSG00000276358(gene)|ensembl:ENSG00000277111(gene)|ensembl:ENST00000430334(transcript)|ensembl:ENST00000613787(transcript)|ensembl:ENST00000617688(transcript)|go:"GO:0005730"(nucleolus)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0015031"(protein transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032418"(lysosome localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044754"(autolysosome)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0046872"(metal ion binding)|go:"GO:0061909"(autophagosome-lysosome fusion)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1902774"(late endosome to lysosome transport)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR004012(RUN)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR025258|interpro:IPR037213|interpro:IPR042827|rcsb pdb:5DPR|rcsb pdb:5DPS|rcsb pdb:5DPT|rcsb pdb:5DPW|refseq:XP_016880940.1|refseq:XP_016880942.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:V+4KyPU2ZkPO8pEuJapznDEnoVk9606	rogid:g3g9CyLRMoFDvX6Yoc231I8+y5E9606	rigid:FT9RizkXLwAEw1TzWltCEipSDvI	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9GZU7	uniprotkb:Q8N2S1	intact:EBI-751587|uniprotkb:Q7Z5Q3|uniprotkb:Q7Z5Q4|uniprotkb:C9IYG0|ensembl:ENSP00000273062	intact:EBI-947718|uniprotkb:O75412|uniprotkb:O75413|uniprotkb:O00508|ensembl:ENSP00000311905	psi-mi:ctds1_human(display_long)|uniprotkb:SCP1(gene name synonym)|uniprotkb:Nuclear LIM interactor-interacting factor 3(gene name synonym)|uniprotkb:CTDSP1(gene name)|psi-mi:CTDSP1(display_short)|uniprotkb:NIF3(gene name synonym)|uniprotkb:NLIIF(gene name synonym)|uniprotkb:Small C-terminal domain phosphatase 1(gene name synonym)	psi-mi:ltbp4_human(display_long)|uniprotkb:LTBP4(gene name)|psi-mi:LTBP4(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509093|imex:IM-28561-1571	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001193807.1|refseq:NP_067021.1|refseq:NP_872580.1|dip:DIP-61246N|ensembl:ENSG00000144579(gene)|ensembl:ENST00000273062(transcript)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008420"(RNA polymerase II CTD heptapeptide repeat phosphatase activity)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR004274(NLI interacting factor)|interpro:IPR011948(Dullard-like phosphatase domain)|interpro:IPR023214|interpro:IPR036412|interpro:IPR040078|mint:Q9GZU7|rcsb pdb:1T9Z|rcsb pdb:1TA0|rcsb pdb:2GHQ|rcsb pdb:2GHT|rcsb pdb:3L0B|rcsb pdb:3L0C|rcsb pdb:3L0Y|rcsb pdb:3PGL|rcsb pdb:4YGY|rcsb pdb:4YH1|rcsb pdb:6DU3	refseq:NP_001036009.1|refseq:NP_001036010.1|refseq:NP_003564.2|ensembl:ENSG00000090006(gene)|ensembl:ENST00000308370(transcript)|go:"GO:0001527"(microfibril)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006457"(protein folding)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007275"(multicellular organism development)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0030252"(growth hormone secretion)|go:"GO:0031012"(extracellular matrix)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0048251"(elastic fiber assembly)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR017878|interpro:IPR018097|interpro:IPR036773|mint:Q8N2S1|reactome:R-HSA-2129379	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:V+4KyPU2ZkPO8pEuJapznDEnoVk9606	rogid:mBWo9asZp3rjkytgvTD+7OE5K5I9606	rigid:M+1Jkyzx76evSjfL3+osP35zCh8	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9GZU7	uniprotkb:A7E2V4	intact:EBI-751587|uniprotkb:Q7Z5Q3|uniprotkb:Q7Z5Q4|uniprotkb:C9IYG0|ensembl:ENSP00000273062	intact:EBI-947995|uniprotkb:Q17RS8|uniprotkb:Q2TAB8|uniprotkb:Q6P439|uniprotkb:Q8IW81|uniprotkb:Q8NB34|uniprotkb:Q9H8F3|uniprotkb:O94987|uniprotkb:B2RP37|ensembl:ENSP00000474748	psi-mi:ctds1_human(display_long)|uniprotkb:SCP1(gene name synonym)|uniprotkb:Nuclear LIM interactor-interacting factor 3(gene name synonym)|uniprotkb:CTDSP1(gene name)|psi-mi:CTDSP1(display_short)|uniprotkb:NIF3(gene name synonym)|uniprotkb:NLIIF(gene name synonym)|uniprotkb:Small C-terminal domain phosphatase 1(gene name synonym)	psi-mi:zswm8_human(display_long)|uniprotkb:ZSWIM8(gene name)|psi-mi:ZSWIM8(display_short)|uniprotkb:KIAA0913(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509086|imex:IM-28561-1569	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001193807.1|refseq:NP_067021.1|refseq:NP_872580.1|dip:DIP-61246N|ensembl:ENSG00000144579(gene)|ensembl:ENST00000273062(transcript)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008420"(RNA polymerase II CTD heptapeptide repeat phosphatase activity)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR004274(NLI interacting factor)|interpro:IPR011948(Dullard-like phosphatase domain)|interpro:IPR023214|interpro:IPR036412|interpro:IPR040078|mint:Q9GZU7|rcsb pdb:1T9Z|rcsb pdb:1TA0|rcsb pdb:2GHQ|rcsb pdb:2GHT|rcsb pdb:3L0B|rcsb pdb:3L0C|rcsb pdb:3L0Y|rcsb pdb:3PGL|rcsb pdb:4YGY|rcsb pdb:4YH1|rcsb pdb:6DU3	refseq:NP_001229416.1|refseq:NP_001229417.1|refseq:NP_055852.2|refseq:XP_006717788.1|ensembl:ENSG00000214655(gene)|ensembl:ENST00000605216(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:1902667"(regulation of axon guidance)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|go:"GO:2000627"(positive regulation of miRNA catabolic process)|interpro:IPR007527(Zinc finger, SWIM-type)|reactome:R-HSA-9010553	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:V+4KyPU2ZkPO8pEuJapznDEnoVk9606	rogid:L/Zc7H24cEC7qtYp34nahN0pKEc9606	rigid:KggXPLeMzOgfO82dxrkGtCViI/E	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9GZU7	uniprotkb:Q86YR5	intact:EBI-751587|uniprotkb:Q7Z5Q3|uniprotkb:Q7Z5Q4|uniprotkb:C9IYG0|ensembl:ENSP00000273062	intact:EBI-741455|uniprotkb:A9Z1X4|uniprotkb:Q86SR5|uniprotkb:Q969T1|uniprotkb:Q9UFS8|uniprotkb:B1B0W3	psi-mi:ctds1_human(display_long)|uniprotkb:SCP1(gene name synonym)|uniprotkb:Nuclear LIM interactor-interacting factor 3(gene name synonym)|uniprotkb:CTDSP1(gene name)|psi-mi:CTDSP1(display_short)|uniprotkb:NIF3(gene name synonym)|uniprotkb:NLIIF(gene name synonym)|uniprotkb:Small C-terminal domain phosphatase 1(gene name synonym)	psi-mi:gpsm1_human(display_long)|uniprotkb:Activator of G-protein signaling 3(gene name synonym)|uniprotkb:GPSM1(gene name)|psi-mi:GPSM1(display_short)|uniprotkb:AGS3(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509079|imex:IM-28561-1567	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001193807.1|refseq:NP_067021.1|refseq:NP_872580.1|dip:DIP-61246N|ensembl:ENSG00000144579(gene)|ensembl:ENST00000273062(transcript)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008420"(RNA polymerase II CTD heptapeptide repeat phosphatase activity)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR004274(NLI interacting factor)|interpro:IPR011948(Dullard-like phosphatase domain)|interpro:IPR023214|interpro:IPR036412|interpro:IPR040078|mint:Q9GZU7|rcsb pdb:1T9Z|rcsb pdb:1TA0|rcsb pdb:2GHQ|rcsb pdb:2GHT|rcsb pdb:3L0B|rcsb pdb:3L0C|rcsb pdb:3L0Y|rcsb pdb:3PGL|rcsb pdb:4YGY|rcsb pdb:4YH1|rcsb pdb:6DU3	refseq:NP_001139111.1|refseq:NP_001186932.1|interpro:IPR003109(GoLoco)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|go:"GO:0000139"(Golgi membrane)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007399"(nervous system development)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0030154"(cell differentiation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:1905098"(negative regulation of guanyl-nucleotide exchange factor activity)|reactome:R-HSA-418594|refseq:NP_001139110.2|refseq:NP_056412.5|mint:Q86YR5|refseq:XP_016870088.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:V+4KyPU2ZkPO8pEuJapznDEnoVk9606	rogid:z9j02+hdH7Kc07ePs0AOgqvIfaA9606	rigid:Zv4hmlssc/SxshN8qEcrMJ6SgdY	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9GZU7	uniprotkb:Q5JTD7	intact:EBI-751587|uniprotkb:Q7Z5Q3|uniprotkb:Q7Z5Q4|uniprotkb:C9IYG0|ensembl:ENSP00000273062	intact:EBI-12003882|ensembl:ENSP00000361518	psi-mi:ctds1_human(display_long)|uniprotkb:SCP1(gene name synonym)|uniprotkb:Nuclear LIM interactor-interacting factor 3(gene name synonym)|uniprotkb:CTDSP1(gene name)|psi-mi:CTDSP1(display_short)|uniprotkb:NIF3(gene name synonym)|uniprotkb:NLIIF(gene name synonym)|uniprotkb:Small C-terminal domain phosphatase 1(gene name synonym)	psi-mi:lrc73_human(display_long)|uniprotkb:LRRC73(gene name)|psi-mi:LRRC73(display_short)|uniprotkb:C6orf154(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509072|imex:IM-28561-1343	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001193807.1|refseq:NP_067021.1|refseq:NP_872580.1|dip:DIP-61246N|ensembl:ENSG00000144579(gene)|ensembl:ENST00000273062(transcript)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008420"(RNA polymerase II CTD heptapeptide repeat phosphatase activity)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR004274(NLI interacting factor)|interpro:IPR011948(Dullard-like phosphatase domain)|interpro:IPR023214|interpro:IPR036412|interpro:IPR040078|mint:Q9GZU7|rcsb pdb:1T9Z|rcsb pdb:1TA0|rcsb pdb:2GHQ|rcsb pdb:2GHT|rcsb pdb:3L0B|rcsb pdb:3L0C|rcsb pdb:3L0Y|rcsb pdb:3PGL|rcsb pdb:4YGY|rcsb pdb:4YH1|rcsb pdb:6DU3	ensembl:ENSG00000204052(gene)|ensembl:ENST00000372441(transcript)|interpro:IPR032675|interpro:IPR039984|mint:Q5JTD7|refseq:NP_001012992.1|refseq:NP_001258811.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:V+4KyPU2ZkPO8pEuJapznDEnoVk9606	rogid:0Vk9403qLSuzVE1dxCB/jdJAOck9606	rigid:GH/0YaQSeQYK5O1CtrHrcQmPgPs	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O76039	uniprotkb:Q9Y6A5	intact:EBI-1752465|uniprotkb:Q14198|uniprotkb:Q5H985|uniprotkb:Q8IYC7|uniprotkb:Q9UJL6|ensembl:ENSP00000485244|uniprotkb:G9B9X4	intact:EBI-2554984|uniprotkb:Q2NKK4|uniprotkb:Q9UMQ1|uniprotkb:Q3KQS5|ensembl:ENSP00000326550|ensembl:ENSP00000498361	psi-mi:cdkl5_human(display_long)|uniprotkb:CDKL5(gene name)|psi-mi:CDKL5(display_short)|uniprotkb:STK9(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 9(gene name synonym)	psi-mi:tacc3_human(display_long)|uniprotkb:ERIC1(gene name synonym)|uniprotkb:ERIC-1(gene name synonym)|uniprotkb:TACC3(gene name)|psi-mi:TACC3(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509065|imex:IM-28561-1341	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000008086(gene)|ensembl:ENST00000623535(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016301"(kinase activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032839"(dendrite cytoplasm)|refseq:NP_001310218.1|refseq:NP_001032420.1|refseq:NP_003150.1|go:"GO:0036064"(ciliary basal body)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0097542"(ciliary tip)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902017"(regulation of cilium assembly)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:4BGQ	refseq:NP_006333.1|ensembl:ENSG00000013810(gene)|ensembl:ENST00000313288(transcript)|ensembl:ENST00000651472(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000922"(spindle pole)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007091"(metaphase/anaphase transition of mitotic cell cycle)|go:"GO:0008283"(cell population proliferation)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0034451"(centriolar satellite)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051301"(cell division)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0072686"(mitotic spindle)|go:"GO:1902850"(microtubule cytoskeleton organization involved in mitosis)|interpro:IPR007707(Transforming acidic coiled-coil-containing)|interpro:IPR039915|rcsb pdb:5LXN|rcsb pdb:5LXO|rcsb pdb:5ODS|rcsb pdb:5ODT|reactome:R-HSA-9013507|reactome:R-HSA-9604323|refseq:XP_016863142.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:jFecXdpQE+yBwqpPPU0ZGcnOheI9606	rogid:gMVaNgiXeS4kmmJ3ol+/hn9HwXc9606	rigid:9xqzY5l+fp2w0QZ6cdFgCsDFFPA	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O76039	uniprotkb:Q9H254	intact:EBI-1752465|uniprotkb:Q14198|uniprotkb:Q5H985|uniprotkb:Q8IYC7|uniprotkb:Q9UJL6|ensembl:ENSP00000485244|uniprotkb:G9B9X4	intact:EBI-308543|uniprotkb:Q9H1K7|uniprotkb:Q9H1K8|uniprotkb:Q9H1K9|uniprotkb:Q9H3G8|uniprotkb:Q9HCD0|uniprotkb:E9PGQ5|uniprotkb:Q9H253|ensembl:ENSP00000263373|ensembl:ENSP00000469242	psi-mi:cdkl5_human(display_long)|uniprotkb:CDKL5(gene name)|psi-mi:CDKL5(display_short)|uniprotkb:STK9(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 9(gene name synonym)	psi-mi:sptn4_human(display_long)|uniprotkb:SPTBN4(gene name)|psi-mi:SPTBN4(display_short)|uniprotkb:KIAA1642(gene name synonym)|uniprotkb:SPTBN3(gene name synonym)|uniprotkb:Spectrin, non-erythroid beta chain 3(gene name synonym)|uniprotkb:Beta-IV spectrin(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509058|imex:IM-28561-1339	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000008086(gene)|ensembl:ENST00000623535(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016301"(kinase activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032839"(dendrite cytoplasm)|refseq:NP_001310218.1|refseq:NP_001032420.1|refseq:NP_003150.1|go:"GO:0036064"(ciliary basal body)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0097542"(ciliary tip)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902017"(regulation of cilium assembly)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:4BGQ	refseq:NP_066022.2|refseq:NP_079489.2|ensembl:ENSP00000263373|ensembl:ENST00000392023|ensembl:ENSP00000375877|ensembl:ENSP00000469242|refseq:XP_016882538.1|ensembl:ENSG00000160460(gene)|ensembl:ENST00000352632(transcript)|ensembl:ENST00000598249(transcript)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0007409"(axonogenesis)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008091"(spectrin)|go:"GO:0009566"(fertilization)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016605"(PML body)|go:"GO:0019226"(transmission of nerve impulse)|go:"GO:0019902"(phosphatase binding)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030507"(spectrin binding)|go:"GO:0033135"(regulation of peptidyl-serine phosphorylation)|go:"GO:0033268"(node of Ranvier)|go:"GO:0033270"(paranode region of axon)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043194"(axon initial segment)|go:"GO:0043203"(axon hillock)|go:"GO:0051693"(actin filament capping)|go:"GO:0061337"(cardiac conduction)|go:"GO:0045162"(clustering of voltage-gated sodium channels)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070852"(cell body fiber)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0106006"(cytoskeletal protein-membrane anchor activity)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001605(Spectrin/pleckstrin-like)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002017(Spectrin repeat)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016343(Spectrin, beta subunit)|interpro:IPR018159|interpro:IPR036872|interpro:IPR041681|reactome:R-HSA-375165|reactome:R-HSA-445095|reactome:R-HSA-5673001|reactome:R-HSA-6807878	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:jFecXdpQE+yBwqpPPU0ZGcnOheI9606	rogid:E/nwpJwY5fu0lc0nCgwV14bgyrs9606	rigid:ok/VvYv13C41ogl+31gnWtYmf1Y	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O76039	uniprotkb:P40692	intact:EBI-1752465|uniprotkb:Q14198|uniprotkb:Q5H985|uniprotkb:Q8IYC7|uniprotkb:Q9UJL6|ensembl:ENSP00000485244|uniprotkb:G9B9X4	intact:EBI-744248|uniprotkb:B4DI13|uniprotkb:B4DQ11|uniprotkb:E9PCU2|ensembl:ENSP00000231790	psi-mi:cdkl5_human(display_long)|uniprotkb:CDKL5(gene name)|psi-mi:CDKL5(display_short)|uniprotkb:STK9(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 9(gene name synonym)	psi-mi:mlh1_human(display_long)|uniprotkb:MutL protein homolog 1(gene name synonym)|uniprotkb:MLH1(gene name)|psi-mi:MLH1(display_short)|uniprotkb:COCA2(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509051|imex:IM-28561-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000008086(gene)|ensembl:ENST00000623535(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016301"(kinase activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032839"(dendrite cytoplasm)|refseq:NP_001310218.1|refseq:NP_001032420.1|refseq:NP_003150.1|go:"GO:0036064"(ciliary basal body)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0097542"(ciliary tip)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902017"(regulation of cilium assembly)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:4BGQ	refseq:NP_000240.1|refseq:NP_001161089.1|refseq:NP_001161090.1|refseq:NP_001161091.1|refseq:NP_001245200.1|refseq:NP_001245202.1|refseq:NP_001245203.1|dip:DIP-27601N|refseq:XP_005265220.1|refseq:XP_005265221.1|ensembl:ENSG00000076242(gene)|ensembl:ENST00000231790(transcript)|go:"GO:0000289"("nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0003682"(chromatin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005712"(chiasma)|go:"GO:0005715"(late recombination nodule)|go:"GO:0006298"(mismatch repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0007060"(male meiosis chromosome segregation)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0016321"(female meiosis chromosome segregation)|go:"GO:0016446"(somatic hypermutation of immunoglobulin genes)|go:"GO:0019899"(enzyme binding)|go:"GO:0032137"(guanine/thymine mispair binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032389"(MutLalpha complex)|go:"GO:0043060"(meiotic metaphase I plate congression)|go:"GO:0045141"(meiotic telomere clustering)|go:"GO:0045190"(isotype switching)|go:"GO:0045950"(negative regulation of mitotic recombination)|go:"GO:0048298"(positive regulation of isotype switching to IgA isotypes)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0048477"(oogenesis)|go:"GO:0051257"(meiotic spindle midzone assembly)|interpro:IPR002099(DNA mismatch repair protein)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR020568|interpro:IPR032189|interpro:IPR036890|interpro:IPR038973|mint:P40692|rcsb pdb:3RBN|rcsb pdb:4P7A|rcsb pdb:5U5P|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5545483|reactome:R-HSA-5632987|reactome:R-HSA-6796648|reactome:R-HSA-912446	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:jFecXdpQE+yBwqpPPU0ZGcnOheI9606	rogid:v/ydpM1Cf5bF27dC+3JF6XXMp0Q9606	rigid:xpmqkVTXUNsa8Ojn/UmOKt8qEu0	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q13936	uniprotkb:P55072	intact:EBI-1038838|uniprotkb:Q13917|uniprotkb:Q13918|uniprotkb:Q13919|uniprotkb:Q13920|uniprotkb:Q13921|uniprotkb:Q13922|uniprotkb:Q13923|uniprotkb:Q13924|uniprotkb:Q13925|uniprotkb:Q13926|uniprotkb:Q13927|uniprotkb:Q13928|uniprotkb:Q13929|uniprotkb:Q13930|uniprotkb:Q13932|uniprotkb:Q13933|uniprotkb:Q14743|uniprotkb:Q14744|uniprotkb:Q15877|uniprotkb:Q4VMI7|uniprotkb:Q4VMI8|uniprotkb:Q4VMI9|uniprotkb:Q6PKM7|uniprotkb:Q8N6C0|uniprotkb:Q99025|uniprotkb:Q99241|uniprotkb:Q99875|uniprotkb:B2RUT3|uniprotkb:E9PDJ0	intact:EBI-355164|uniprotkb:Q969G7|uniprotkb:Q9UCD5|uniprotkb:B2R5T8|uniprotkb:Q0V924|uniprotkb:Q2TAI5|intact:EBI-1046421|ensembl:ENSP00000351777	psi-mi:cac1c_human(display_long)|uniprotkb:CACNA1C(gene name)|psi-mi:CACNA1C(display_short)|uniprotkb:CACH2(gene name synonym)|uniprotkb:CACN2(gene name synonym)|uniprotkb:CACNL1A1(gene name synonym)|uniprotkb:CCHL1A1(gene name synonym)|uniprotkb:Voltage-gated calcium channel subunit alpha Cav1.2(gene name synonym)|uniprotkb:Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle(gene name synonym)	psi-mi:tera_human(display_long)|uniprotkb:VCP(gene name)|psi-mi:VCP(display_short)|uniprotkb:"15S Mg(2+)-ATPase p97 subunit"(gene name synonym)|uniprotkb:Valosin-containing protein(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509042|imex:IM-28561-1107	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000710.5|refseq:NP_001123299.1|refseq:NP_001123301.1|refseq:NP_001123303.1|refseq:NP_001123304.1|refseq:NP_001123305.1|refseq:NP_001123306.1|refseq:NP_001123307.1|refseq:NP_001123314.1|refseq:NP_001123315.1|refseq:NP_001123308.1|refseq:NP_001123309.1|refseq:NP_001123310.1|refseq:NP_001123311.1|refseq:NP_001123312.1|refseq:NP_001123313.1|refseq:NP_001123316.1|refseq:NP_001123318.1|refseq:NP_001161095.1|refseq:NP_001161097.1|refseq:NP_001123302.2|refseq:NP_001161096.2|refseq:NP_955630.3|reactome:R-HSA-5576893|reactome:R-HSA-400042|reactome:R-HSA-419037|reactome:R-HSA-422356|go:"GO:0002520"(immune system development)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007507"(heart development)|go:"GO:0008331"(high voltage-gated calcium channel activity)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030425"(dendrite)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035585"(calcium-mediated signaling using extracellular calcium source)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043204"(perikaryon)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0061337"(cardiac conduction)|go:"GO:0061577"(calcium ion transmembrane transport via high voltage-gated calcium channel)|go:"GO:0070509"(calcium ion import)|go:"GO:0086002"(cardiac muscle cell action potential involved in contraction)|go:"GO:0086007"(voltage-gated calcium channel activity involved in cardiac muscle cell action potential)|go:"GO:0086012"(membrane depolarization during cardiac muscle cell action potential)|go:"GO:0086045"(membrane depolarization during AV node cell action potential)|go:"GO:0086056"(voltage-gated calcium channel activity involved in AV node cell action potential)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|go:"GO:0098912"(membrane depolarization during atrial cardiac muscle cell action potential)|go:"GO:1990454"(L-type voltage-gated calcium channel complex)|interpro:IPR002077(Voltage-dependent calcium channel, alpha-1 subunit)|interpro:IPR005446(Voltage-dependent calcium channel, L-type, alpha-1 subunit)|interpro:IPR005451(Voltage-dependent calcium channel, L-type, alpha-1C subunit)|interpro:IPR005821(Ion transport)|interpro:IPR014873(Voltage-dependent calcium channel, alpha-1 subunit, IQ domain)|interpro:IPR027359|interpro:IPR031649|interpro:IPR031688|rcsb pdb:1T0J|rcsb pdb:2BE6|rcsb pdb:2F3Y|rcsb pdb:2F3Z|rcsb pdb:2LQC|rcsb pdb:3G43|rcsb pdb:3OXQ|rcsb pdb:5V2P|rcsb pdb:5V2Q|rcsb pdb:6C0A|rcsb pdb:6DAD|rcsb pdb:6DAE|rcsb pdb:6DAF|rcsb pdb:6U39|rcsb pdb:6U3A|rcsb pdb:6U3B|rcsb pdb:6U3D|go:"GO:0070588"(calcium ion transmembrane transport)|reactome:R-HSA-5576892|dip:DIP-29589N	refseq:NP_009057.1|rcsb pdb:7BPA|rcsb pdb:7BPB|rcsb pdb:7JY5|reactome:R-HSA-110320|reactome:R-HSA-3371511|reactome:R-HSA-382556|reactome:R-HSA-532668|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5678895|reactome:R-HSA-5689877|reactome:R-HSA-5689896|reactome:R-HSA-6798695|reactome:R-HSA-8866654|reactome:R-HSA-8876725|reactome:R-HSA-9013407|reactome:R-HSA-9646399|reactome:R-HSA-9678110|reactome:R-HSA-9694614|rcsb pdb:7BP9|go:"GO:0032510"(endosome to lysosome transport via multivesicular body sorting pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0035617"(stress granule disassembly)|go:"GO:0035800"(deubiquitinase activator activity)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0036435"(K48-linked polyubiquitin modification-dependent protein binding)|go:"GO:0036503"(ERAD pathway)|go:"GO:0036513"(Derlin-1 retrotranslocation complex)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043531"(ADP binding)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051228"(mitotic spindle disassembly)|go:"GO:0061857"(endoplasmic reticulum stress-induced pre-emptive quality control)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070842"(aggresome assembly)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0072389"(flavin adenine dinucleotide catabolic process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106300"(protein-DNA covalent cross-linking repair)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1903006"(positive regulation of protein K63-linked deubiquitination)|go:"GO:1903007"(positive regulation of Lys63-specific deubiquitinase activity)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:1903843"(cellular response to arsenite ion)|go:"GO:1903862"(positive regulation of oxidative phosphorylation)|go:"GO:1904288"(BAT3 complex binding)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1904949"(ATPase complex)|go:"GO:1905634"(regulation of protein localization to chromatin)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990730"(VCP-NSFL1C complex)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR003338(AAA ATPase VAT, N-terminal)|interpro:IPR003593(AAA+ ATPase, core)|ensembl:ENSG00000165280(gene)|ensembl:ENST00000358901(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006734"(NADH metabolic process)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006914"(autophagy)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008289"(lipid binding)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0016236"(macroautophagy)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019079"(viral genome replication)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019985"(translesion synthesis)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR004201(Cell division protein 48, CDC48, domain 2)|interpro:IPR005938(AAA ATPase, CDC48)|interpro:IPR009010(Aspartate decarboxylase-like fold)|interpro:IPR015415(Vps4 oligomerisation, C-terminal)|interpro:IPR027417|interpro:IPR029067|interpro:IPR041569|mint:P55072|rcsb pdb:3EBB|rcsb pdb:3HU1|rcsb pdb:3HU2|rcsb pdb:3HU3|rcsb pdb:3QC8|rcsb pdb:3QQ7|rcsb pdb:3QQ8|rcsb pdb:3QWZ|rcsb pdb:3TIW|rcsb pdb:4KDI|rcsb pdb:4KDL|rcsb pdb:4KLN|rcsb pdb:4KO8|rcsb pdb:4KOD|rcsb pdb:4P0A|rcsb pdb:5B6C|rcsb pdb:5C18|rcsb pdb:5C19|rcsb pdb:5C1A|rcsb pdb:5C1B|rcsb pdb:5DYG|rcsb pdb:5DYI|rcsb pdb:5EPP|rcsb pdb:5FTJ|rcsb pdb:5FTK|rcsb pdb:5FTL|rcsb pdb:5FTM|rcsb pdb:5FTN|rcsb pdb:5GLF|rcsb pdb:5IFS|rcsb pdb:5IFW|rcsb pdb:5KIW|rcsb pdb:5KIY|rcsb pdb:5X4L|rcsb pdb:6G2V|rcsb pdb:6G2W|rcsb pdb:6G2X|rcsb pdb:6G2Y|rcsb pdb:6G2Z|rcsb pdb:6G30|rcsb pdb:6HD0|rcsb pdb:6MCK|rcsb pdb:7BP8|dip:DIP-33543N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:dhWcWUTulWYd/nQtGorjr481/XA9606	rogid:HrjDhdsDcgaf8HEbqqMjUqxPaEs9606	rigid:UA+vIEunF/7Po0KWl+T16YTMjnc	false	sufficient binding region:1841-2221	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q13936	uniprotkb:Q8NFZ5	intact:EBI-1038838|uniprotkb:Q13917|uniprotkb:Q13918|uniprotkb:Q13919|uniprotkb:Q13920|uniprotkb:Q13921|uniprotkb:Q13922|uniprotkb:Q13923|uniprotkb:Q13924|uniprotkb:Q13925|uniprotkb:Q13926|uniprotkb:Q13927|uniprotkb:Q13928|uniprotkb:Q13929|uniprotkb:Q13930|uniprotkb:Q13932|uniprotkb:Q13933|uniprotkb:Q14743|uniprotkb:Q14744|uniprotkb:Q15877|uniprotkb:Q4VMI7|uniprotkb:Q4VMI8|uniprotkb:Q4VMI9|uniprotkb:Q6PKM7|uniprotkb:Q8N6C0|uniprotkb:Q99025|uniprotkb:Q99241|uniprotkb:Q99875|uniprotkb:B2RUT3|uniprotkb:E9PDJ0	intact:EBI-359372|uniprotkb:Q7L5L2|uniprotkb:Q9BQR6|uniprotkb:Q9H682|uniprotkb:B1AKS4|uniprotkb:B3KTY8|uniprotkb:D3DVQ9|ensembl:ENSP00000321203	psi-mi:cac1c_human(display_long)|uniprotkb:CACNA1C(gene name)|psi-mi:CACNA1C(display_short)|uniprotkb:CACH2(gene name synonym)|uniprotkb:CACN2(gene name synonym)|uniprotkb:CACNL1A1(gene name synonym)|uniprotkb:CCHL1A1(gene name synonym)|uniprotkb:Voltage-gated calcium channel subunit alpha Cav1.2(gene name synonym)|uniprotkb:Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle(gene name synonym)	psi-mi:tnip2_human(display_long)|uniprotkb:TNIP2(gene name)|psi-mi:TNIP2(display_short)|uniprotkb:ABIN2(gene name synonym)|uniprotkb:FLIP1(gene name synonym)|uniprotkb:Fetal liver LKB1-interacting protein(gene name synonym)|uniprotkb:A20-binding inhibitor of NF-kappa-B activation 2(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509033|imex:IM-28561-1105	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000710.5|refseq:NP_001123299.1|refseq:NP_001123301.1|refseq:NP_001123303.1|refseq:NP_001123304.1|refseq:NP_001123305.1|refseq:NP_001123306.1|refseq:NP_001123307.1|refseq:NP_001123314.1|refseq:NP_001123315.1|refseq:NP_001123308.1|refseq:NP_001123309.1|refseq:NP_001123310.1|refseq:NP_001123311.1|refseq:NP_001123312.1|refseq:NP_001123313.1|refseq:NP_001123316.1|refseq:NP_001123318.1|refseq:NP_001161095.1|refseq:NP_001161097.1|refseq:NP_001123302.2|refseq:NP_001161096.2|refseq:NP_955630.3|reactome:R-HSA-5576893|reactome:R-HSA-400042|reactome:R-HSA-419037|reactome:R-HSA-422356|go:"GO:0002520"(immune system development)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007507"(heart development)|go:"GO:0008331"(high voltage-gated calcium channel activity)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030425"(dendrite)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035585"(calcium-mediated signaling using extracellular calcium source)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043204"(perikaryon)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0061337"(cardiac conduction)|go:"GO:0061577"(calcium ion transmembrane transport via high voltage-gated calcium channel)|go:"GO:0070509"(calcium ion import)|go:"GO:0086002"(cardiac muscle cell action potential involved in contraction)|go:"GO:0086007"(voltage-gated calcium channel activity involved in cardiac muscle cell action potential)|go:"GO:0086012"(membrane depolarization during cardiac muscle cell action potential)|go:"GO:0086045"(membrane depolarization during AV node cell action potential)|go:"GO:0086056"(voltage-gated calcium channel activity involved in AV node cell action potential)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|go:"GO:0098912"(membrane depolarization during atrial cardiac muscle cell action potential)|go:"GO:1990454"(L-type voltage-gated calcium channel complex)|interpro:IPR002077(Voltage-dependent calcium channel, alpha-1 subunit)|interpro:IPR005446(Voltage-dependent calcium channel, L-type, alpha-1 subunit)|interpro:IPR005451(Voltage-dependent calcium channel, L-type, alpha-1C subunit)|interpro:IPR005821(Ion transport)|interpro:IPR014873(Voltage-dependent calcium channel, alpha-1 subunit, IQ domain)|interpro:IPR027359|interpro:IPR031649|interpro:IPR031688|rcsb pdb:1T0J|rcsb pdb:2BE6|rcsb pdb:2F3Y|rcsb pdb:2F3Z|rcsb pdb:2LQC|rcsb pdb:3G43|rcsb pdb:3OXQ|rcsb pdb:5V2P|rcsb pdb:5V2Q|rcsb pdb:6C0A|rcsb pdb:6DAD|rcsb pdb:6DAE|rcsb pdb:6DAF|rcsb pdb:6U39|rcsb pdb:6U3A|rcsb pdb:6U3B|rcsb pdb:6U3D|go:"GO:0070588"(calcium ion transmembrane transport)|reactome:R-HSA-5576892|dip:DIP-29589N	refseq:NP_001154999.1|refseq:NP_077285.3|ensembl:ENSG00000168884(gene)|ensembl:ENST00000315423(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR022008|interpro:IPR034735|mint:Q8NFZ5|rcsb pdb:5H07|reactome:R-HSA-5684264|reactome:R-HSA-5689896|refseq:NP_001278945.1|dip:DIP-27617N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:dhWcWUTulWYd/nQtGorjr481/XA9606	rogid:K9Ee06++lTFEHy1d/3tMu6uwyU09606	rigid:d/jdB/Hrm722BeOsOno2Zsgn7xg	false	sufficient binding region:1841-2221	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q13936	uniprotkb:Q9BXP5	intact:EBI-1038838|uniprotkb:Q13917|uniprotkb:Q13918|uniprotkb:Q13919|uniprotkb:Q13920|uniprotkb:Q13921|uniprotkb:Q13922|uniprotkb:Q13923|uniprotkb:Q13924|uniprotkb:Q13925|uniprotkb:Q13926|uniprotkb:Q13927|uniprotkb:Q13928|uniprotkb:Q13929|uniprotkb:Q13930|uniprotkb:Q13932|uniprotkb:Q13933|uniprotkb:Q14743|uniprotkb:Q14744|uniprotkb:Q15877|uniprotkb:Q4VMI7|uniprotkb:Q4VMI8|uniprotkb:Q4VMI9|uniprotkb:Q6PKM7|uniprotkb:Q8N6C0|uniprotkb:Q99025|uniprotkb:Q99241|uniprotkb:Q99875|uniprotkb:B2RUT3|uniprotkb:E9PDJ0	intact:EBI-712721|uniprotkb:A4D2E5|uniprotkb:A6NK22|uniprotkb:Q32MI4|uniprotkb:Q9Y4S4|ensembl:ENSP00000480421|uniprotkb:O95808|uniprotkb:Q9BWP6|uniprotkb:Q9BXP4|uniprotkb:A4D2E6|uniprotkb:B4DJL4|uniprotkb:B4DZA6|uniprotkb:Q6NT74|uniprotkb:Q8TDQ5	psi-mi:cac1c_human(display_long)|uniprotkb:CACNA1C(gene name)|psi-mi:CACNA1C(display_short)|uniprotkb:CACH2(gene name synonym)|uniprotkb:CACN2(gene name synonym)|uniprotkb:CACNL1A1(gene name synonym)|uniprotkb:CCHL1A1(gene name synonym)|uniprotkb:Voltage-gated calcium channel subunit alpha Cav1.2(gene name synonym)|uniprotkb:Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle(gene name synonym)	psi-mi:srrt_human(display_long)|uniprotkb:SRRT(gene name)|psi-mi:SRRT(display_short)|uniprotkb:ASR2(gene name synonym)|uniprotkb:ARS2(gene name synonym)|uniprotkb:Arsenite-resistance protein 2(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509024|imex:IM-28561-1565	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000710.5|refseq:NP_001123299.1|refseq:NP_001123301.1|refseq:NP_001123303.1|refseq:NP_001123304.1|refseq:NP_001123305.1|refseq:NP_001123306.1|refseq:NP_001123307.1|refseq:NP_001123314.1|refseq:NP_001123315.1|refseq:NP_001123308.1|refseq:NP_001123309.1|refseq:NP_001123310.1|refseq:NP_001123311.1|refseq:NP_001123312.1|refseq:NP_001123313.1|refseq:NP_001123316.1|refseq:NP_001123318.1|refseq:NP_001161095.1|refseq:NP_001161097.1|refseq:NP_001123302.2|refseq:NP_001161096.2|refseq:NP_955630.3|reactome:R-HSA-5576893|reactome:R-HSA-400042|reactome:R-HSA-419037|reactome:R-HSA-422356|go:"GO:0002520"(immune system development)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007507"(heart development)|go:"GO:0008331"(high voltage-gated calcium channel activity)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030425"(dendrite)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035585"(calcium-mediated signaling using extracellular calcium source)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043204"(perikaryon)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0061337"(cardiac conduction)|go:"GO:0061577"(calcium ion transmembrane transport via high voltage-gated calcium channel)|go:"GO:0070509"(calcium ion import)|go:"GO:0086002"(cardiac muscle cell action potential involved in contraction)|go:"GO:0086007"(voltage-gated calcium channel activity involved in cardiac muscle cell action potential)|go:"GO:0086012"(membrane depolarization during cardiac muscle cell action potential)|go:"GO:0086045"(membrane depolarization during AV node cell action potential)|go:"GO:0086056"(voltage-gated calcium channel activity involved in AV node cell action potential)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|go:"GO:0098912"(membrane depolarization during atrial cardiac muscle cell action potential)|go:"GO:1990454"(L-type voltage-gated calcium channel complex)|interpro:IPR002077(Voltage-dependent calcium channel, alpha-1 subunit)|interpro:IPR005446(Voltage-dependent calcium channel, L-type, alpha-1 subunit)|interpro:IPR005451(Voltage-dependent calcium channel, L-type, alpha-1C subunit)|interpro:IPR005821(Ion transport)|interpro:IPR014873(Voltage-dependent calcium channel, alpha-1 subunit, IQ domain)|interpro:IPR027359|interpro:IPR031649|interpro:IPR031688|rcsb pdb:1T0J|rcsb pdb:2BE6|rcsb pdb:2F3Y|rcsb pdb:2F3Z|rcsb pdb:2LQC|rcsb pdb:3G43|rcsb pdb:3OXQ|rcsb pdb:5V2P|rcsb pdb:5V2Q|rcsb pdb:6C0A|rcsb pdb:6DAD|rcsb pdb:6DAE|rcsb pdb:6DAF|rcsb pdb:6U39|rcsb pdb:6U3A|rcsb pdb:6U3B|rcsb pdb:6U3D|go:"GO:0070588"(calcium ion transmembrane transport)|reactome:R-HSA-5576892|dip:DIP-29589N	ensembl:ENST00000611405(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006397"(mRNA processing)|go:"GO:0016604"(nuclear body)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0140262"(mRNA cap binding complex binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR007042(Arsenite-resistance protein 2)|interpro:IPR021933|interpro:IPR035979|interpro:IPR039727|mint:Q9BXP5|rcsb pdb:5OO6|rcsb pdb:6F7J|rcsb pdb:6F7P|rcsb pdb:6F7S|rcsb pdb:6F8D|reactome:R-HSA-6807505|reactome:R-HSA-72163|ensembl:ENSG00000087087(gene)|refseq:NP_001122324.1|refseq:NP_001122325.1|refseq:NP_001122326.1|refseq:NP_056992.4	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:dhWcWUTulWYd/nQtGorjr481/XA9606	rogid:upRnTwa7LTUzxnbGtfpJUejg2+w9606	rigid:vGSGEV2RxSuowGqvXKcCJjQ8zqU	false	sufficient binding region:1841-2221	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q7Z5B4	uniprotkb:Q13936	intact:EBI-7429000|uniprotkb:Q6UX78|uniprotkb:B2RD25|uniprotkb:Q86T94|uniprotkb:D3DQU5|uniprotkb:B0B1U0|uniprotkb:Q7Z5B3|intact:MINT-8343009|uniprotkb:Q9HAH8|uniprotkb:Q8TBJ9|ensembl:ENSP00000308820	intact:EBI-1038838|uniprotkb:Q13917|uniprotkb:Q13918|uniprotkb:Q13919|uniprotkb:Q13920|uniprotkb:Q13921|uniprotkb:Q13922|uniprotkb:Q13923|uniprotkb:Q13924|uniprotkb:Q13925|uniprotkb:Q13926|uniprotkb:Q13927|uniprotkb:Q13928|uniprotkb:Q13929|uniprotkb:Q13930|uniprotkb:Q13932|uniprotkb:Q13933|uniprotkb:Q14743|uniprotkb:Q14744|uniprotkb:Q15877|uniprotkb:Q4VMI7|uniprotkb:Q4VMI8|uniprotkb:Q4VMI9|uniprotkb:Q6PKM7|uniprotkb:Q8N6C0|uniprotkb:Q99025|uniprotkb:Q99241|uniprotkb:Q99875|uniprotkb:B2RUT3|uniprotkb:E9PDJ0	psi-mi:ric3_human(display_long)|uniprotkb:RIC3(gene name)|psi-mi:RIC3(display_short)|uniprotkb:Resistant to inhibitor of cholinesterase 3(gene name synonym)|uniprotkb:UNQ720/PRO1385(orf name)	psi-mi:cac1c_human(display_long)|uniprotkb:CACNA1C(gene name)|psi-mi:CACNA1C(display_short)|uniprotkb:CACH2(gene name synonym)|uniprotkb:CACN2(gene name synonym)|uniprotkb:CACNL1A1(gene name synonym)|uniprotkb:CCHL1A1(gene name synonym)|uniprotkb:Voltage-gated calcium channel subunit alpha Cav1.2(gene name synonym)|uniprotkb:Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509015|imex:IM-28561-661	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001333619.1|refseq:NP_078833.3|refseq:NP_001128581.1|refseq:NP_001193600.1|refseq:NP_001193601.1|ensembl:ENSG00000166405(gene)|ensembl:ENST00000309737(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0016021"(integral component of membrane)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034622"|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045202"(synapse)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR026160|interpro:IPR032763|refseq:XP_006718381.1	refseq:NP_000710.5|refseq:NP_001123299.1|refseq:NP_001123301.1|refseq:NP_001123303.1|refseq:NP_001123304.1|refseq:NP_001123305.1|refseq:NP_001123306.1|refseq:NP_001123307.1|refseq:NP_001123314.1|refseq:NP_001123315.1|refseq:NP_001123308.1|refseq:NP_001123309.1|refseq:NP_001123310.1|refseq:NP_001123311.1|refseq:NP_001123312.1|refseq:NP_001123313.1|refseq:NP_001123316.1|refseq:NP_001123318.1|refseq:NP_001161095.1|refseq:NP_001161097.1|refseq:NP_001123302.2|refseq:NP_001161096.2|refseq:NP_955630.3|reactome:R-HSA-5576893|reactome:R-HSA-400042|reactome:R-HSA-419037|reactome:R-HSA-422356|go:"GO:0002520"(immune system development)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007507"(heart development)|go:"GO:0008331"(high voltage-gated calcium channel activity)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030425"(dendrite)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035585"(calcium-mediated signaling using extracellular calcium source)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043204"(perikaryon)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0061337"(cardiac conduction)|go:"GO:0061577"(calcium ion transmembrane transport via high voltage-gated calcium channel)|go:"GO:0070509"(calcium ion import)|go:"GO:0086002"(cardiac muscle cell action potential involved in contraction)|go:"GO:0086007"(voltage-gated calcium channel activity involved in cardiac muscle cell action potential)|go:"GO:0086012"(membrane depolarization during cardiac muscle cell action potential)|go:"GO:0086045"(membrane depolarization during AV node cell action potential)|go:"GO:0086056"(voltage-gated calcium channel activity involved in AV node cell action potential)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|go:"GO:0098912"(membrane depolarization during atrial cardiac muscle cell action potential)|go:"GO:1990454"(L-type voltage-gated calcium channel complex)|interpro:IPR002077(Voltage-dependent calcium channel, alpha-1 subunit)|interpro:IPR005446(Voltage-dependent calcium channel, L-type, alpha-1 subunit)|interpro:IPR005451(Voltage-dependent calcium channel, L-type, alpha-1C subunit)|interpro:IPR005821(Ion transport)|interpro:IPR014873(Voltage-dependent calcium channel, alpha-1 subunit, IQ domain)|interpro:IPR027359|interpro:IPR031649|interpro:IPR031688|rcsb pdb:1T0J|rcsb pdb:2BE6|rcsb pdb:2F3Y|rcsb pdb:2F3Z|rcsb pdb:2LQC|rcsb pdb:3G43|rcsb pdb:3OXQ|rcsb pdb:5V2P|rcsb pdb:5V2Q|rcsb pdb:6C0A|rcsb pdb:6DAD|rcsb pdb:6DAE|rcsb pdb:6DAF|rcsb pdb:6U39|rcsb pdb:6U3A|rcsb pdb:6U3B|rcsb pdb:6U3D|go:"GO:0070588"(calcium ion transmembrane transport)|reactome:R-HSA-5576892|dip:DIP-29589N	-	comment:mint|comment:homomint	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:6H6VzdUvPKV5eoeoaRry7/T5qhg9606	rogid:dhWcWUTulWYd/nQtGorjr481/XA9606	rigid:o9VRbEriP4s+eryco+bXemcedbg	false	-	sufficient binding region:1841-2221	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q13936	uniprotkb:Q9NRD5	intact:EBI-1038838|uniprotkb:Q13917|uniprotkb:Q13918|uniprotkb:Q13919|uniprotkb:Q13920|uniprotkb:Q13921|uniprotkb:Q13922|uniprotkb:Q13923|uniprotkb:Q13924|uniprotkb:Q13925|uniprotkb:Q13926|uniprotkb:Q13927|uniprotkb:Q13928|uniprotkb:Q13929|uniprotkb:Q13930|uniprotkb:Q13932|uniprotkb:Q13933|uniprotkb:Q14743|uniprotkb:Q14744|uniprotkb:Q15877|uniprotkb:Q4VMI7|uniprotkb:Q4VMI8|uniprotkb:Q4VMI9|uniprotkb:Q6PKM7|uniprotkb:Q8N6C0|uniprotkb:Q99025|uniprotkb:Q99241|uniprotkb:Q99875|uniprotkb:B2RUT3|uniprotkb:E9PDJ0	intact:EBI-79165|uniprotkb:O95906|ensembl:ENSP00000349465|ensembl:ENSP00000385205|intact:EBI-2622151|uniprotkb:B3KS52	psi-mi:cac1c_human(display_long)|uniprotkb:CACNA1C(gene name)|psi-mi:CACNA1C(display_short)|uniprotkb:CACH2(gene name synonym)|uniprotkb:CACN2(gene name synonym)|uniprotkb:CACNL1A1(gene name synonym)|uniprotkb:CCHL1A1(gene name synonym)|uniprotkb:Voltage-gated calcium channel subunit alpha Cav1.2(gene name synonym)|uniprotkb:Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle(gene name synonym)	psi-mi:pick1_human(display_long)|uniprotkb:PICK1(gene name)|psi-mi:PICK1(display_short)|uniprotkb:PRKCABP(gene name synonym)|uniprotkb:Protein kinase C-alpha-binding protein(gene name synonym)|uniprotkb:Protein interacting with C kinase 1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509006|imex:IM-28561-1563	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000710.5|refseq:NP_001123299.1|refseq:NP_001123301.1|refseq:NP_001123303.1|refseq:NP_001123304.1|refseq:NP_001123305.1|refseq:NP_001123306.1|refseq:NP_001123307.1|refseq:NP_001123314.1|refseq:NP_001123315.1|refseq:NP_001123308.1|refseq:NP_001123309.1|refseq:NP_001123310.1|refseq:NP_001123311.1|refseq:NP_001123312.1|refseq:NP_001123313.1|refseq:NP_001123316.1|refseq:NP_001123318.1|refseq:NP_001161095.1|refseq:NP_001161097.1|refseq:NP_001123302.2|refseq:NP_001161096.2|refseq:NP_955630.3|reactome:R-HSA-5576893|reactome:R-HSA-400042|reactome:R-HSA-419037|reactome:R-HSA-422356|go:"GO:0002520"(immune system development)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007507"(heart development)|go:"GO:0008331"(high voltage-gated calcium channel activity)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030425"(dendrite)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035585"(calcium-mediated signaling using extracellular calcium source)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043204"(perikaryon)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0061337"(cardiac conduction)|go:"GO:0061577"(calcium ion transmembrane transport via high voltage-gated calcium channel)|go:"GO:0070509"(calcium ion import)|go:"GO:0086002"(cardiac muscle cell action potential involved in contraction)|go:"GO:0086007"(voltage-gated calcium channel activity involved in cardiac muscle cell action potential)|go:"GO:0086012"(membrane depolarization during cardiac muscle cell action potential)|go:"GO:0086045"(membrane depolarization during AV node cell action potential)|go:"GO:0086056"(voltage-gated calcium channel activity involved in AV node cell action potential)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|go:"GO:0098912"(membrane depolarization during atrial cardiac muscle cell action potential)|go:"GO:1990454"(L-type voltage-gated calcium channel complex)|interpro:IPR002077(Voltage-dependent calcium channel, alpha-1 subunit)|interpro:IPR005446(Voltage-dependent calcium channel, L-type, alpha-1 subunit)|interpro:IPR005451(Voltage-dependent calcium channel, L-type, alpha-1C subunit)|interpro:IPR005821(Ion transport)|interpro:IPR014873(Voltage-dependent calcium channel, alpha-1 subunit, IQ domain)|interpro:IPR027359|interpro:IPR031649|interpro:IPR031688|rcsb pdb:1T0J|rcsb pdb:2BE6|rcsb pdb:2F3Y|rcsb pdb:2F3Z|rcsb pdb:2LQC|rcsb pdb:3G43|rcsb pdb:3OXQ|rcsb pdb:5V2P|rcsb pdb:5V2Q|rcsb pdb:6C0A|rcsb pdb:6DAD|rcsb pdb:6DAE|rcsb pdb:6DAF|rcsb pdb:6U39|rcsb pdb:6U3A|rcsb pdb:6U3B|rcsb pdb:6U3D|go:"GO:0070588"(calcium ion transmembrane transport)|reactome:R-HSA-5576892|dip:DIP-29589N	ensembl:ENSG00000100151(gene)|ensembl:ENST00000356976(transcript)|ensembl:ENST00000404072(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|refseq:NP_001034672.1|refseq:NP_001034673.1|refseq:NP_036539.1|go:"GO:0015844"(monoamine transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021782"(glial cell development)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0034315"(regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0034316"(negative regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0036294"(cellular response to decreased oxygen levels)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0043113"(receptor clustering)|go:"GO:0045161"(neuronal ion channel clustering)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051015"(actin filament binding)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0098842"(postsynaptic early endosome)|go:"GO:0140090"(membrane curvature sensor activity)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR010504(Arfaptin-like)|interpro:IPR027267|interpro:IPR030798|interpro:IPR036034|interpro:IPR037959|mint:Q9NRD5|rcsb pdb:2GZV|rcsb pdb:6AR4|rcsb pdb:6BJN|rcsb pdb:6BJO|reactome:R-HSA-202733|reactome:R-HSA-416993	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:dhWcWUTulWYd/nQtGorjr481/XA9606	rogid:qRx+eNG7We8Oe0SQOekqpJpn8zk9606	rigid:zEDYVUnXY1rvdeeE4ONLLCoYkJY	false	sufficient binding region:1841-2221	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q13936	uniprotkb:Q8WUM0	intact:EBI-1038838|uniprotkb:Q13917|uniprotkb:Q13918|uniprotkb:Q13919|uniprotkb:Q13920|uniprotkb:Q13921|uniprotkb:Q13922|uniprotkb:Q13923|uniprotkb:Q13924|uniprotkb:Q13925|uniprotkb:Q13926|uniprotkb:Q13927|uniprotkb:Q13928|uniprotkb:Q13929|uniprotkb:Q13930|uniprotkb:Q13932|uniprotkb:Q13933|uniprotkb:Q14743|uniprotkb:Q14744|uniprotkb:Q15877|uniprotkb:Q4VMI7|uniprotkb:Q4VMI8|uniprotkb:Q4VMI9|uniprotkb:Q6PKM7|uniprotkb:Q8N6C0|uniprotkb:Q99025|uniprotkb:Q99241|uniprotkb:Q99875|uniprotkb:B2RUT3|uniprotkb:E9PDJ0	intact:EBI-295695|uniprotkb:Q5T8N0|uniprotkb:Q9H9W2|uniprotkb:Q9NV71|uniprotkb:Q9NVC4|uniprotkb:B2RAZ8|ensembl:ENSP00000261396	psi-mi:cac1c_human(display_long)|uniprotkb:CACNA1C(gene name)|psi-mi:CACNA1C(display_short)|uniprotkb:CACH2(gene name synonym)|uniprotkb:CACN2(gene name synonym)|uniprotkb:CACNL1A1(gene name synonym)|uniprotkb:CCHL1A1(gene name synonym)|uniprotkb:Voltage-gated calcium channel subunit alpha Cav1.2(gene name synonym)|uniprotkb:Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle(gene name synonym)	psi-mi:nu133_human(display_long)|uniprotkb:NUP133(gene name)|psi-mi:NUP133(display_short)|uniprotkb:Nucleoporin Nup133(gene name synonym)|uniprotkb:133 kDa nucleoporin(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26508997|imex:IM-28561-425	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000710.5|refseq:NP_001123299.1|refseq:NP_001123301.1|refseq:NP_001123303.1|refseq:NP_001123304.1|refseq:NP_001123305.1|refseq:NP_001123306.1|refseq:NP_001123307.1|refseq:NP_001123314.1|refseq:NP_001123315.1|refseq:NP_001123308.1|refseq:NP_001123309.1|refseq:NP_001123310.1|refseq:NP_001123311.1|refseq:NP_001123312.1|refseq:NP_001123313.1|refseq:NP_001123316.1|refseq:NP_001123318.1|refseq:NP_001161095.1|refseq:NP_001161097.1|refseq:NP_001123302.2|refseq:NP_001161096.2|refseq:NP_955630.3|reactome:R-HSA-5576893|reactome:R-HSA-400042|reactome:R-HSA-419037|reactome:R-HSA-422356|go:"GO:0002520"(immune system development)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007507"(heart development)|go:"GO:0008331"(high voltage-gated calcium channel activity)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030425"(dendrite)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035585"(calcium-mediated signaling using extracellular calcium source)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043204"(perikaryon)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0061337"(cardiac conduction)|go:"GO:0061577"(calcium ion transmembrane transport via high voltage-gated calcium channel)|go:"GO:0070509"(calcium ion import)|go:"GO:0086002"(cardiac muscle cell action potential involved in contraction)|go:"GO:0086007"(voltage-gated calcium channel activity involved in cardiac muscle cell action potential)|go:"GO:0086012"(membrane depolarization during cardiac muscle cell action potential)|go:"GO:0086045"(membrane depolarization during AV node cell action potential)|go:"GO:0086056"(voltage-gated calcium channel activity involved in AV node cell action potential)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|go:"GO:0098912"(membrane depolarization during atrial cardiac muscle cell action potential)|go:"GO:1990454"(L-type voltage-gated calcium channel complex)|interpro:IPR002077(Voltage-dependent calcium channel, alpha-1 subunit)|interpro:IPR005446(Voltage-dependent calcium channel, L-type, alpha-1 subunit)|interpro:IPR005451(Voltage-dependent calcium channel, L-type, alpha-1C subunit)|interpro:IPR005821(Ion transport)|interpro:IPR014873(Voltage-dependent calcium channel, alpha-1 subunit, IQ domain)|interpro:IPR027359|interpro:IPR031649|interpro:IPR031688|rcsb pdb:1T0J|rcsb pdb:2BE6|rcsb pdb:2F3Y|rcsb pdb:2F3Z|rcsb pdb:2LQC|rcsb pdb:3G43|rcsb pdb:3OXQ|rcsb pdb:5V2P|rcsb pdb:5V2Q|rcsb pdb:6C0A|rcsb pdb:6DAD|rcsb pdb:6DAE|rcsb pdb:6DAF|rcsb pdb:6U39|rcsb pdb:6U3A|rcsb pdb:6U3B|rcsb pdb:6U3D|go:"GO:0070588"(calcium ion transmembrane transport)|reactome:R-HSA-5576892|dip:DIP-29589N	refseq:NP_060700.2|ensembl:ENSG00000069248(gene)|ensembl:ENST00000261396(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0000972"(transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005829"(cytosol)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006999"(nuclear pore organization)|go:"GO:0016020"(membrane)|go:"GO:0016973"("poly(A)+ mRNA export from nucleus")|go:"GO:0017056"(structural constituent of nuclear pore)|go:"GO:0021915"(neural tube development)|go:"GO:0022008"(neurogenesis)|go:"GO:0031080"(nuclear pore outer ring)|go:"GO:0031965"(nuclear membrane)|go:"GO:0048339"(paraxial mesoderm development)|go:"GO:0061053"(somite development)|go:"GO:0072006"(nephron development)|interpro:IPR007187(Nucleoporin, Nup133-like, C-terminal)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR037624|mint:Q8WUM0|rcsb pdb:1XKS|rcsb pdb:3CQC|rcsb pdb:3CQG|rcsb pdb:3I4R|rcsb pdb:5A9Q|reactome:R-HSA-1169408|reactome:R-HSA-141444|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-5663220|reactome:R-HSA-6784531|reactome:R-HSA-68877|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9615933|reactome:R-HSA-9648025	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:dhWcWUTulWYd/nQtGorjr481/XA9606	rogid:J89Ja9KNryxKNUd9rqNbi8EC09g9606	rigid:CBs3x47/ffEPzzIG47i+9X8cs5w	false	sufficient binding region:1841-2221	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q13936	uniprotkb:Q13099	intact:EBI-1038838|uniprotkb:Q13917|uniprotkb:Q13918|uniprotkb:Q13919|uniprotkb:Q13920|uniprotkb:Q13921|uniprotkb:Q13922|uniprotkb:Q13923|uniprotkb:Q13924|uniprotkb:Q13925|uniprotkb:Q13926|uniprotkb:Q13927|uniprotkb:Q13928|uniprotkb:Q13929|uniprotkb:Q13930|uniprotkb:Q13932|uniprotkb:Q13933|uniprotkb:Q14743|uniprotkb:Q14744|uniprotkb:Q15877|uniprotkb:Q4VMI7|uniprotkb:Q4VMI8|uniprotkb:Q4VMI9|uniprotkb:Q6PKM7|uniprotkb:Q8N6C0|uniprotkb:Q99025|uniprotkb:Q99241|uniprotkb:Q99875|uniprotkb:B2RUT3|uniprotkb:E9PDJ0	intact:EBI-347427|uniprotkb:A2A491|uniprotkb:Q5SZJ6|uniprotkb:Q8N719|uniprotkb:B4DUS2|ensembl:ENSP00000261632	psi-mi:cac1c_human(display_long)|uniprotkb:CACNA1C(gene name)|psi-mi:CACNA1C(display_short)|uniprotkb:CACH2(gene name synonym)|uniprotkb:CACN2(gene name synonym)|uniprotkb:CACNL1A1(gene name synonym)|uniprotkb:CCHL1A1(gene name synonym)|uniprotkb:Voltage-gated calcium channel subunit alpha Cav1.2(gene name synonym)|uniprotkb:Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle(gene name synonym)	psi-mi:ift88_human(display_long)|uniprotkb:IFT88(gene name)|psi-mi:IFT88(display_short)|uniprotkb:TG737(gene name synonym)|uniprotkb:Tetratricopeptide repeat protein 10(gene name synonym)|uniprotkb:Recessive polycystic kidney disease protein Tg737 homolog(gene name synonym)|uniprotkb:TTC10(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26508988|imex:IM-28561-873	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000710.5|refseq:NP_001123299.1|refseq:NP_001123301.1|refseq:NP_001123303.1|refseq:NP_001123304.1|refseq:NP_001123305.1|refseq:NP_001123306.1|refseq:NP_001123307.1|refseq:NP_001123314.1|refseq:NP_001123315.1|refseq:NP_001123308.1|refseq:NP_001123309.1|refseq:NP_001123310.1|refseq:NP_001123311.1|refseq:NP_001123312.1|refseq:NP_001123313.1|refseq:NP_001123316.1|refseq:NP_001123318.1|refseq:NP_001161095.1|refseq:NP_001161097.1|refseq:NP_001123302.2|refseq:NP_001161096.2|refseq:NP_955630.3|reactome:R-HSA-5576893|reactome:R-HSA-400042|reactome:R-HSA-419037|reactome:R-HSA-422356|go:"GO:0002520"(immune system development)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007507"(heart development)|go:"GO:0008331"(high voltage-gated calcium channel activity)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030425"(dendrite)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035585"(calcium-mediated signaling using extracellular calcium source)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043204"(perikaryon)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0061337"(cardiac conduction)|go:"GO:0061577"(calcium ion transmembrane transport via high voltage-gated calcium channel)|go:"GO:0070509"(calcium ion import)|go:"GO:0086002"(cardiac muscle cell action potential involved in contraction)|go:"GO:0086007"(voltage-gated calcium channel activity involved in cardiac muscle cell action potential)|go:"GO:0086012"(membrane depolarization during cardiac muscle cell action potential)|go:"GO:0086045"(membrane depolarization during AV node cell action potential)|go:"GO:0086056"(voltage-gated calcium channel activity involved in AV node cell action potential)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|go:"GO:0098912"(membrane depolarization during atrial cardiac muscle cell action potential)|go:"GO:1990454"(L-type voltage-gated calcium channel complex)|interpro:IPR002077(Voltage-dependent calcium channel, alpha-1 subunit)|interpro:IPR005446(Voltage-dependent calcium channel, L-type, alpha-1 subunit)|interpro:IPR005451(Voltage-dependent calcium channel, L-type, alpha-1C subunit)|interpro:IPR005821(Ion transport)|interpro:IPR014873(Voltage-dependent calcium channel, alpha-1 subunit, IQ domain)|interpro:IPR027359|interpro:IPR031649|interpro:IPR031688|rcsb pdb:1T0J|rcsb pdb:2BE6|rcsb pdb:2F3Y|rcsb pdb:2F3Z|rcsb pdb:2LQC|rcsb pdb:3G43|rcsb pdb:3OXQ|rcsb pdb:5V2P|rcsb pdb:5V2Q|rcsb pdb:6C0A|rcsb pdb:6DAD|rcsb pdb:6DAE|rcsb pdb:6DAF|rcsb pdb:6U39|rcsb pdb:6U3A|rcsb pdb:6U3B|rcsb pdb:6U3D|go:"GO:0070588"(calcium ion transmembrane transport)|reactome:R-HSA-5576892|dip:DIP-29589N	refseq:NP_783195.2|refseq:XP_011533543.1|refseq:XP_016876247.1|refseq:NP_001305420.1|interpro:IPR019734|interpro:IPR011990(Tetratricopeptide-like helical)|reactome:R-HSA-5610787|reactome:R-HSA-5620924|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9646399|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0019894"(kinesin binding)|go:"GO:0030992"(intraciliary transport particle B)|go:"GO:0031514"(motile cilium)|go:"GO:0036064"(ciliary basal body)|go:"GO:0036126"(sperm flagellum)|go:"GO:0042073"(intraciliary transport)|go:"GO:0060122"(inner ear receptor cell stereocilium organization)|go:"GO:0060271"(cilium assembly)|go:"GO:0097542"(ciliary tip)|go:"GO:0097546"(ciliary base)|go:"GO:0097730"(non-motile cilium)|go:"GO:1902017"(regulation of cilium assembly)|go:"GO:1905515"(non-motile cilium assembly)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR006597(Sel1-like)|ensembl:ENSG00000032742(gene)|ensembl:ENST00000351808(transcript)|go:"GO:0001822"(kidney development)|refseq:XP_005266610.1|refseq:NP_006522.2|refseq:XP_006719933.1|refseq:XP_011533544.1|refseq:XP_011533545.1|refseq:XP_016876246.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:dhWcWUTulWYd/nQtGorjr481/XA9606	rogid:kUeWmfrvdFuel6K1rJDf+5AtNAA9606	rigid:YD9+S8QSbddIbVktFewB0Jd3RfU	false	sufficient binding region:1841-2221	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P78352	uniprotkb:O95886	intact:EBI-80389|ensembl:ENSP00000382425|intact:EBI-1760259|uniprotkb:Q92941|uniprotkb:Q9UKK8|intact:EBI-1965339|uniprotkb:B7Z1S1|uniprotkb:G5E939	intact:EBI-1752541|uniprotkb:Q5TDD5|uniprotkb:Q9H3X7|ensembl:ENSP00000235180|ensembl:ENSP00000362444	psi-mi:dlg4_human(display_long)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)|uniprotkb:DLG4(gene name)|psi-mi:DLG4(display_short)|uniprotkb:PSD95(gene name synonym)	psi-mi:dlgp3_human(display_long)|uniprotkb:DLGAP3(gene name)|psi-mi:DLGAP3(display_short)|uniprotkb:DAP3(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 3(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 3(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509182|imex:IM-28561-461	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000132535(gene)|ensembl:ENST00000399506(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007399"(nervous system development)|go:"GO:0007612"(learning)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019900"(kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:P78352|rcsb pdb:1KEF|rcsb pdb:2MES|rcsb pdb:3I4W|rcsb pdb:3K82|rcsb pdb:3ZRT|rcsb pdb:5J7J|rcsb pdb:5JXB|rcsb pdb:6QJD|rcsb pdb:6QJF|rcsb pdb:6QJG|rcsb pdb:6QJI|rcsb pdb:6QJJ|rcsb pdb:6QJK|rcsb pdb:6QJL|rcsb pdb:6QJN|rcsb pdb:6SPV|rcsb pdb:6SPZ|reactome:R-HSA-1236394|reactome:R-HSA-399719|reactome:R-HSA-438066|reactome:R-HSA-442982|reactome:R-HSA-447038|reactome:R-HSA-451308|reactome:R-HSA-5673001|reactome:R-HSA-5682910|reactome:R-HSA-6794361|reactome:R-HSA-8849932|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-5625900|reactome:R-HSA-9620244|refseq:NP_001308004.1|refseq:NP_001356.1|refseq:NP_001122299.1|dip:DIP-30919N	refseq:XP_011540181.1|refseq:NP_001073887.1|ensembl:ENSG00000116544(gene)|ensembl:ENST00000235180(transcript)|ensembl:ENST00000373347(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0014069"(postsynaptic density)|go:"GO:0023052"(signaling)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098981"(cholinergic synapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030526|mint:O95886|reactome:R-HSA-6794361	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:VhIVoWngQFYTjco3EzG0If9uh+Y9606	rogid:Srxbe/eHss3qKoCFJes6yed29wQ9606	rigid:hybiKGZrrgTXtzotgxhH6MYIFzQ	false	sufficient binding region:546-724	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P78352	uniprotkb:O14490	intact:EBI-80389|ensembl:ENSP00000382425|intact:EBI-1760259|uniprotkb:Q92941|uniprotkb:Q9UKK8|intact:EBI-1965339|uniprotkb:B7Z1S1|uniprotkb:G5E939	intact:EBI-1753207|uniprotkb:O14489|uniprotkb:P78335|uniprotkb:B2RMU8|uniprotkb:B7WPA1|uniprotkb:A8MWN8|uniprotkb:B7Z2H2|uniprotkb:B7Z2I2|uniprotkb:B7Z9Y4|ensembl:ENSP00000316377	psi-mi:dlg4_human(display_long)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)|uniprotkb:DLG4(gene name)|psi-mi:DLG4(display_short)|uniprotkb:PSD95(gene name synonym)	psi-mi:dlgp1_human(display_long)|uniprotkb:DLGAP1(gene name)|psi-mi:DLGAP1(display_short)|uniprotkb:DAP1(gene name synonym)|uniprotkb:GKAP(gene name synonym)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509173|imex:IM-28561-261	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000132535(gene)|ensembl:ENST00000399506(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007399"(nervous system development)|go:"GO:0007612"(learning)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019900"(kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:P78352|rcsb pdb:1KEF|rcsb pdb:2MES|rcsb pdb:3I4W|rcsb pdb:3K82|rcsb pdb:3ZRT|rcsb pdb:5J7J|rcsb pdb:5JXB|rcsb pdb:6QJD|rcsb pdb:6QJF|rcsb pdb:6QJG|rcsb pdb:6QJI|rcsb pdb:6QJJ|rcsb pdb:6QJK|rcsb pdb:6QJL|rcsb pdb:6QJN|rcsb pdb:6SPV|rcsb pdb:6SPZ|reactome:R-HSA-1236394|reactome:R-HSA-399719|reactome:R-HSA-438066|reactome:R-HSA-442982|reactome:R-HSA-447038|reactome:R-HSA-451308|reactome:R-HSA-5673001|reactome:R-HSA-5682910|reactome:R-HSA-6794361|reactome:R-HSA-8849932|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-5625900|reactome:R-HSA-9620244|refseq:NP_001308004.1|refseq:NP_001356.1|refseq:NP_001122299.1|dip:DIP-30919N	refseq:NP_001003809.1|refseq:NP_001229690.1|refseq:NP_001229691.1|refseq:NP_001229692.1|refseq:NP_001229693.1|refseq:NP_001229694.1|refseq:NP_001229695.1|refseq:NP_004737.2|ensembl:ENSG00000170579(gene)|ensembl:ENST00000315677(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0014069"(postsynaptic density)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:O14490|rcsb pdb:5YPO|rcsb pdb:6TNQ|rcsb pdb:6TQ0|reactome:R-HSA-6794361	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:VhIVoWngQFYTjco3EzG0If9uh+Y9606	rogid:fGISLkYSlOD5ioIPFU8bVuBObMg9606	rigid:lN/LJV6ylZEmom9qF3FcXcUUOaw	false	sufficient binding region:546-724	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P78352	uniprotkb:P78352	intact:EBI-80389|ensembl:ENSP00000382425|intact:EBI-1760259|uniprotkb:Q92941|uniprotkb:Q9UKK8|intact:EBI-1965339|uniprotkb:B7Z1S1|uniprotkb:G5E939	intact:EBI-80389|ensembl:ENSP00000382425|intact:EBI-1760259|uniprotkb:Q92941|uniprotkb:Q9UKK8|intact:EBI-1965339|uniprotkb:B7Z1S1|uniprotkb:G5E939	psi-mi:dlg4_human(display_long)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)|uniprotkb:DLG4(gene name)|psi-mi:DLG4(display_short)|uniprotkb:PSD95(gene name synonym)	psi-mi:dlg4_human(display_long)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)|uniprotkb:DLG4(gene name)|psi-mi:DLG4(display_short)|uniprotkb:PSD95(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509164|imex:IM-28561-61	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000132535(gene)|ensembl:ENST00000399506(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007399"(nervous system development)|go:"GO:0007612"(learning)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019900"(kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:P78352|rcsb pdb:1KEF|rcsb pdb:2MES|rcsb pdb:3I4W|rcsb pdb:3K82|rcsb pdb:3ZRT|rcsb pdb:5J7J|rcsb pdb:5JXB|rcsb pdb:6QJD|rcsb pdb:6QJF|rcsb pdb:6QJG|rcsb pdb:6QJI|rcsb pdb:6QJJ|rcsb pdb:6QJK|rcsb pdb:6QJL|rcsb pdb:6QJN|rcsb pdb:6SPV|rcsb pdb:6SPZ|reactome:R-HSA-1236394|reactome:R-HSA-399719|reactome:R-HSA-438066|reactome:R-HSA-442982|reactome:R-HSA-447038|reactome:R-HSA-451308|reactome:R-HSA-5673001|reactome:R-HSA-5682910|reactome:R-HSA-6794361|reactome:R-HSA-8849932|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-5625900|reactome:R-HSA-9620244|refseq:NP_001308004.1|refseq:NP_001356.1|refseq:NP_001122299.1|dip:DIP-30919N	ensembl:ENSG00000132535(gene)|ensembl:ENST00000399506(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007399"(nervous system development)|go:"GO:0007612"(learning)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019900"(kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:P78352|rcsb pdb:1KEF|rcsb pdb:2MES|rcsb pdb:3I4W|rcsb pdb:3K82|rcsb pdb:3ZRT|rcsb pdb:5J7J|rcsb pdb:5JXB|rcsb pdb:6QJD|rcsb pdb:6QJF|rcsb pdb:6QJG|rcsb pdb:6QJI|rcsb pdb:6QJJ|rcsb pdb:6QJK|rcsb pdb:6QJL|rcsb pdb:6QJN|rcsb pdb:6SPV|rcsb pdb:6SPZ|reactome:R-HSA-1236394|reactome:R-HSA-399719|reactome:R-HSA-438066|reactome:R-HSA-442982|reactome:R-HSA-447038|reactome:R-HSA-451308|reactome:R-HSA-5673001|reactome:R-HSA-5682910|reactome:R-HSA-6794361|reactome:R-HSA-8849932|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-5625900|reactome:R-HSA-9620244|refseq:NP_001308004.1|refseq:NP_001356.1|refseq:NP_001122299.1|dip:DIP-30919N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:VhIVoWngQFYTjco3EzG0If9uh+Y9606	rogid:VhIVoWngQFYTjco3EzG0If9uh+Y9606	rigid:aYEc7FMRfvBm8jzfVBD4R7qkXCc	false	sufficient binding region:298-550	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P78352	uniprotkb:Q9BUH8	intact:EBI-80389|ensembl:ENSP00000382425|intact:EBI-1760259|uniprotkb:Q92941|uniprotkb:Q9UKK8|intact:EBI-1965339|uniprotkb:B7Z1S1|uniprotkb:G5E939	intact:EBI-742722|uniprotkb:Q9NPU3|uniprotkb:Q9P282|ensembl:ENSP00000347301|ensembl:ENSP00000411124|ensembl:ENSP00000450722|ensembl:ENSP00000451397|ensembl:ENSP00000452157	psi-mi:dlg4_human(display_long)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)|uniprotkb:DLG4(gene name)|psi-mi:DLG4(display_short)|uniprotkb:PSD95(gene name synonym)	psi-mi:begin_human(display_long)|uniprotkb:BEGAIN(gene name)|psi-mi:BEGAIN(display_short)|uniprotkb:KIAA1446(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509137|imex:IM-28561-429	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000132535(gene)|ensembl:ENST00000399506(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007399"(nervous system development)|go:"GO:0007612"(learning)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019900"(kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:P78352|rcsb pdb:1KEF|rcsb pdb:2MES|rcsb pdb:3I4W|rcsb pdb:3K82|rcsb pdb:3ZRT|rcsb pdb:5J7J|rcsb pdb:5JXB|rcsb pdb:6QJD|rcsb pdb:6QJF|rcsb pdb:6QJG|rcsb pdb:6QJI|rcsb pdb:6QJJ|rcsb pdb:6QJK|rcsb pdb:6QJL|rcsb pdb:6QJN|rcsb pdb:6SPV|rcsb pdb:6SPZ|reactome:R-HSA-1236394|reactome:R-HSA-399719|reactome:R-HSA-438066|reactome:R-HSA-442982|reactome:R-HSA-447038|reactome:R-HSA-451308|reactome:R-HSA-5673001|reactome:R-HSA-5682910|reactome:R-HSA-6794361|reactome:R-HSA-8849932|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-5625900|reactome:R-HSA-9620244|refseq:NP_001308004.1|refseq:NP_001356.1|refseq:NP_001122299.1|dip:DIP-30919N	refseq:NP_001153003.1|refseq:NP_065887.1|ensembl:ENSG00000183092(gene)|ensembl:ENST00000355173(transcript)|ensembl:ENST00000443071(transcript)|ensembl:ENST00000553553(transcript)|ensembl:ENST00000556188(transcript)|ensembl:ENST00000557378(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0016020"(membrane)|go:"GO:0045202"(synapse)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|interpro:IPR033584|interpro:IPR043441|mint:Q9BUH8|reactome:R-HSA-6794361|refseq:XP_005267978.1|refseq:XP_016877010.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:VhIVoWngQFYTjco3EzG0If9uh+Y9606	rogid:v1sC6hCp3f55UuN7Itg5h6KZbWQ9606	rigid:yllGTFguxBlOiy0FQOPvZex2e1g	false	sufficient binding region:546-724	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P78352	uniprotkb:P07910	intact:EBI-80389|ensembl:ENSP00000382425|intact:EBI-1760259|uniprotkb:Q92941|uniprotkb:Q9UKK8|intact:EBI-1965339|uniprotkb:B7Z1S1|uniprotkb:G5E939	intact:EBI-357966|uniprotkb:P22628|uniprotkb:Q53EX2|uniprotkb:Q59FD3|uniprotkb:Q5FWE8|uniprotkb:Q86SF8|uniprotkb:Q86U45|uniprotkb:Q96HK7|uniprotkb:Q96HM4|uniprotkb:Q96IY5|uniprotkb:Q9BTS3|uniprotkb:D3DS19|uniprotkb:D3DS22|intact:EBI-28976506|ensembl:ENSP00000404848|ensembl:ENSP00000451291|ensembl:ENSP00000452276	psi-mi:dlg4_human(display_long)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)|uniprotkb:DLG4(gene name)|psi-mi:DLG4(display_short)|uniprotkb:PSD95(gene name synonym)	psi-mi:hnrpc_human(display_long)|uniprotkb:HNRNPC(gene name)|psi-mi:HNRNPC(display_short)|uniprotkb:HNRPC(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509250|imex:IM-28561-301	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000132535(gene)|ensembl:ENST00000399506(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007399"(nervous system development)|go:"GO:0007612"(learning)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019900"(kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:P78352|rcsb pdb:1KEF|rcsb pdb:2MES|rcsb pdb:3I4W|rcsb pdb:3K82|rcsb pdb:3ZRT|rcsb pdb:5J7J|rcsb pdb:5JXB|rcsb pdb:6QJD|rcsb pdb:6QJF|rcsb pdb:6QJG|rcsb pdb:6QJI|rcsb pdb:6QJJ|rcsb pdb:6QJK|rcsb pdb:6QJL|rcsb pdb:6QJN|rcsb pdb:6SPV|rcsb pdb:6SPZ|reactome:R-HSA-1236394|reactome:R-HSA-399719|reactome:R-HSA-438066|reactome:R-HSA-442982|reactome:R-HSA-447038|reactome:R-HSA-451308|reactome:R-HSA-5673001|reactome:R-HSA-5682910|reactome:R-HSA-6794361|reactome:R-HSA-8849932|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-5625900|reactome:R-HSA-9620244|refseq:NP_001308004.1|refseq:NP_001356.1|refseq:NP_001122299.1|dip:DIP-30919N	refseq:NP_001070910.1|refseq:NP_001070911.1|refseq:NP_004491.2|refseq:NP_112604.2|ensembl:ENSP00000404848|ensembl:ENST00000430246|ensembl:ENSP00000442816|ensembl:ENST00000553300|ensembl:ENSP00000450544|ensembl:ENSP00000451291|ensembl:ENST00000554969|ensembl:ENSP00000452276|ensembl:ENSP00000450725|ensembl:ENST00000555883|ensembl:ENSP00000450629|ensembl:ENST00000556628|ensembl:ENSP00000451652|ensembl:ENST00000556897|ensembl:ENSP00000451176|refseq:XP_011535010.1|refseq:XP_011535011.1|refseq:XP_011535012.1|refseq:XP_011535013.1|refseq:XP_011535014.1|refseq:XP_016876741.1|refseq:XP_016876742.1|dip:DIP-29854N|refseq:XP_006720188.1|ensembl:ENSG00000092199(gene)|ensembl:ENST00000420743(transcript)|ensembl:ENST00000554455(transcript)|ensembl:ENST00000557201(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000785"(chromatin)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0031492"(nucleosomal DNA binding)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043044"|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1990247"(N6-methyladenosine-containing RNA binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR017347(Heterogeneous nuclear ribonucleoprotein C, Raly)|interpro:IPR035979|mint:P07910|rcsb pdb:1TXP|rcsb pdb:1WF2|rcsb pdb:2MXY|rcsb pdb:2MZ1|rcsb pdb:3LN4|reactome:R-HSA-4570464|reactome:R-HSA-72163|reactome:R-HSA-72203|reactome:R-HSA-9013418|reactome:R-HSA-9013422	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:VhIVoWngQFYTjco3EzG0If9uh+Y9606	rogid:Fj5tiH0wrNUjTnsURIg8dB8laMg9606	rigid:/USVowrpVVUpKp1LSAXjRbl5PTk	false	sufficient binding region:546-724	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q12879	uniprotkb:P78352	intact:EBI-7249937|uniprotkb:Q17RZ6|uniprotkb:O00669|intact:MINT-414776|ensembl:ENSP00000332549|ensembl:ENSP00000379818	intact:EBI-80389|ensembl:ENSP00000382425|intact:EBI-1760259|uniprotkb:Q92941|uniprotkb:Q9UKK8|intact:EBI-1965339|uniprotkb:B7Z1S1|uniprotkb:G5E939	psi-mi:nmde1_human(display_long)|uniprotkb:GRIN2A(gene name)|psi-mi:GRIN2A(display_short)|uniprotkb:NMDAR2A(gene name synonym)|uniprotkb:Glutamate [NMDA] receptor subunit epsilon-1(gene name synonym)|uniprotkb:N-methyl D-aspartate receptor subtype 2A(gene name synonym)	psi-mi:dlg4_human(display_long)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)|uniprotkb:DLG4(gene name)|psi-mi:DLG4(display_short)|uniprotkb:PSD95(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509243|imex:IM-28561-1661	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011520763.1|refseq:NP_000824.1|refseq:NP_001127880.1|refseq:NP_001127879.1|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|ensembl:ENSG00000183454(gene)|go:"GO:0030431"(sleep)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0033058"(directional locomotion)|go:"GO:0038023"(signaling receptor activity)|ensembl:ENST00000330684(transcript)|ensembl:ENST00000396573(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042428"(serotonin metabolic process)|go:"GO:0042493"|go:"GO:0042734"(presynaptic membrane)|go:"GO:0001964"(startle response)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0001975"(response to amphetamine)|go:"GO:0043197"(dendritic spine)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0045471"(response to ethanol)|go:"GO:0007420"(brain development)|go:"GO:0007611"(learning or memory)|go:"GO:0007613"(memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008542"(visual learning)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0022008"(neurogenesis)|go:"GO:0098976"(excitatory chemical synaptic transmission)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:1903539"(protein localization to postsynaptic membrane)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR018884|interpro:IPR019594|interpro:IPR028082|mint:Q12879|rcsb pdb:3NFL|rcsb pdb:5H8F|rcsb pdb:5H8H|rcsb pdb:5H8N|rcsb pdb:5H8Q|rcsb pdb:5I2K|rcsb pdb:5I2N|rcsb pdb:5KCJ|rcsb pdb:5KDT|rcsb pdb:5TP9|rcsb pdb:5TPA|rcsb pdb:6IRA|rcsb pdb:6IRF|rcsb pdb:6IRG|rcsb pdb:6IRH|rcsb pdb:7EOQ|rcsb pdb:7EOR|rcsb pdb:7EOS|rcsb pdb:7EOT|rcsb pdb:7EOU|reactome:R-HSA-438066|reactome:R-HSA-6794361|reactome:R-HSA-8849932|reactome:R-HSA-9022699|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-9620244|go:"GO:0098839"(postsynaptic density membrane)|dip:DIP-40798N	ensembl:ENSG00000132535(gene)|ensembl:ENST00000399506(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007399"(nervous system development)|go:"GO:0007612"(learning)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019900"(kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:P78352|rcsb pdb:1KEF|rcsb pdb:2MES|rcsb pdb:3I4W|rcsb pdb:3K82|rcsb pdb:3ZRT|rcsb pdb:5J7J|rcsb pdb:5JXB|rcsb pdb:6QJD|rcsb pdb:6QJF|rcsb pdb:6QJG|rcsb pdb:6QJI|rcsb pdb:6QJJ|rcsb pdb:6QJK|rcsb pdb:6QJL|rcsb pdb:6QJN|rcsb pdb:6SPV|rcsb pdb:6SPZ|reactome:R-HSA-1236394|reactome:R-HSA-399719|reactome:R-HSA-438066|reactome:R-HSA-442982|reactome:R-HSA-447038|reactome:R-HSA-451308|reactome:R-HSA-5673001|reactome:R-HSA-5682910|reactome:R-HSA-6794361|reactome:R-HSA-8849932|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-5625900|reactome:R-HSA-9620244|refseq:NP_001308004.1|refseq:NP_001356.1|refseq:NP_001122299.1|dip:DIP-30919N	-	comment:mint|function:NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Activation requires binding of agonist to both types of subunits	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:TgxknLgEUv+HeST8sJLtK2pYoEM9606	rogid:VhIVoWngQFYTjco3EzG0If9uh+Y9606	rigid:ba20knxDrz2ihtC8RUWmIy9X1fY	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P81274	uniprotkb:P78352	intact:EBI-618655|uniprotkb:Q5T1N8|ensembl:ENSP00000264126|ensembl:ENSP00000385510|ensembl:ENSP00000392138|ensembl:ENSP00000496104|ensembl:ENSP00000496756|ensembl:ENSP00000502178|uniprotkb:Q8N0Z5|uniprotkb:Q6IBL7	intact:EBI-80389|ensembl:ENSP00000382425|intact:EBI-1760259|uniprotkb:Q92941|uniprotkb:Q9UKK8|intact:EBI-1965339|uniprotkb:B7Z1S1|uniprotkb:G5E939	psi-mi:gpsm2_human(display_long)|uniprotkb:GPSM2(gene name)|psi-mi:GPSM2(display_short)|uniprotkb:LGN(gene name synonym)|uniprotkb:Mosaic protein LGN(gene name synonym)	psi-mi:dlg4_human(display_long)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)|uniprotkb:DLG4(gene name)|psi-mi:DLG4(display_short)|uniprotkb:PSD95(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509234|imex:IM-28561-1443	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000121957(gene)|ensembl:ENST00000264126(transcript)|ensembl:ENST00000406462(transcript)|ensembl:ENST00000446797(transcript)|ensembl:ENST00000642355(transcript)|ensembl:ENST00000645164(transcript)|ensembl:ENST00000676184(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000166"(nucleotide binding)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031291"(Ran protein signal transduction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0051301"(cell division)|go:"GO:0051661"(maintenance of centrosome location)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0070840"(dynein complex binding)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0097575"(lateral cell cortex)|go:"GO:0099738"(cell cortex region)|go:"GO:1904778"(positive regulation of protein localization to cell cortex)|go:"GO:1905832"(positive regulation of spindle assembly)|interpro:IPR003109(GoLoco)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|mint:P81274|rcsb pdb:3SF4|rcsb pdb:4WND|rcsb pdb:4WNE|rcsb pdb:4WNF|rcsb pdb:4WNG|rcsb pdb:5A6C|rcsb pdb:6HC2|reactome:R-HSA-418594|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0007052"(mitotic spindle organization)|refseq:NP_037428.3|refseq:NP_001307967.1|refseq:NP_001307968.1|refseq:XP_011539603.1|refseq:XP_011539604.1|refseq:XP_016856586.1|refseq:XP_016856587.1|dip:DIP-399N	ensembl:ENSG00000132535(gene)|ensembl:ENST00000399506(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007399"(nervous system development)|go:"GO:0007612"(learning)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019900"(kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:P78352|rcsb pdb:1KEF|rcsb pdb:2MES|rcsb pdb:3I4W|rcsb pdb:3K82|rcsb pdb:3ZRT|rcsb pdb:5J7J|rcsb pdb:5JXB|rcsb pdb:6QJD|rcsb pdb:6QJF|rcsb pdb:6QJG|rcsb pdb:6QJI|rcsb pdb:6QJJ|rcsb pdb:6QJK|rcsb pdb:6QJL|rcsb pdb:6QJN|rcsb pdb:6SPV|rcsb pdb:6SPZ|reactome:R-HSA-1236394|reactome:R-HSA-399719|reactome:R-HSA-438066|reactome:R-HSA-442982|reactome:R-HSA-447038|reactome:R-HSA-451308|reactome:R-HSA-5673001|reactome:R-HSA-5682910|reactome:R-HSA-6794361|reactome:R-HSA-8849932|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-5625900|reactome:R-HSA-9620244|refseq:NP_001308004.1|refseq:NP_001356.1|refseq:NP_001122299.1|dip:DIP-30919N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:qQOgAYWYhHlMg4d8HsqCxcNqnNg9606	rogid:VhIVoWngQFYTjco3EzG0If9uh+Y9606	rigid:0Rj9lA/cZhZc7irizeUoZYxsw8E	false	-	sufficient binding region:546-724	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P78352	uniprotkb:Q08379	intact:EBI-80389|ensembl:ENSP00000382425|intact:EBI-1760259|uniprotkb:Q92941|uniprotkb:Q9UKK8|intact:EBI-1965339|uniprotkb:B7Z1S1|uniprotkb:G5E939	intact:EBI-618309|intact:EBI-28970132|ensembl:ENSP00000478799|uniprotkb:Q6GRM9|uniprotkb:Q9BRB0|uniprotkb:Q9NYF9|uniprotkb:A0A0C4DGS5|intact:EBI-11522202	psi-mi:dlg4_human(display_long)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)|uniprotkb:DLG4(gene name)|psi-mi:DLG4(display_short)|uniprotkb:PSD95(gene name synonym)	psi-mi:goga2_human(display_long)|uniprotkb:GOLGA2(gene name)|psi-mi:GOLGA2(display_short)|uniprotkb:130 kDa cis-Golgi matrix protein(gene name synonym)|uniprotkb:GM130 autoantigen(gene name synonym)|uniprotkb:Golgin-95(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509227|imex:IM-28561-541	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000132535(gene)|ensembl:ENST00000399506(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007399"(nervous system development)|go:"GO:0007612"(learning)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019900"(kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:P78352|rcsb pdb:1KEF|rcsb pdb:2MES|rcsb pdb:3I4W|rcsb pdb:3K82|rcsb pdb:3ZRT|rcsb pdb:5J7J|rcsb pdb:5JXB|rcsb pdb:6QJD|rcsb pdb:6QJF|rcsb pdb:6QJG|rcsb pdb:6QJI|rcsb pdb:6QJJ|rcsb pdb:6QJK|rcsb pdb:6QJL|rcsb pdb:6QJN|rcsb pdb:6SPV|rcsb pdb:6SPZ|reactome:R-HSA-1236394|reactome:R-HSA-399719|reactome:R-HSA-438066|reactome:R-HSA-442982|reactome:R-HSA-447038|reactome:R-HSA-451308|reactome:R-HSA-5673001|reactome:R-HSA-5682910|reactome:R-HSA-6794361|reactome:R-HSA-8849932|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-5625900|reactome:R-HSA-9620244|refseq:NP_001308004.1|refseq:NP_001356.1|refseq:NP_001122299.1|dip:DIP-30919N	ensembl:ENSG00000167110(gene)|ensembl:ENST00000611957(transcript)|go:"GO:0000137"(Golgi cis cisterna)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000922"(spindle pole)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005874"(microtubule)|go:"GO:0006486"(protein glycosylation)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007030"(Golgi organization)|go:"GO:0007098"(centrosome cycle)|go:"GO:0008017"(microtubule binding)|go:"GO:0008356"(asymmetric cell division)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0015031"(protein transport)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0060050"(positive regulation of protein glycosylation)|go:"GO:0061676"(importin-alpha family protein binding)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090161"(Golgi ribbon formation)|go:"GO:0090166"(Golgi disassembly)|go:"GO:0090306"(meiotic spindle assembly)|go:"GO:0090307"(mitotic spindle assembly)|interpro:IPR024858|interpro:IPR043937|interpro:IPR043976|mint:Q08379|rcsb pdb:4REY|rcsb pdb:6IW8|rcsb pdb:6IWA|rcsb pdb:6K06|reactome:R-HSA-162658|reactome:R-HSA-204005|reactome:R-HSA-6807878|reactome:R-HSA-8862803|refseq:NP_004477.3|ensembl:ENSP00000478799|dip:DIP-34271N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:VhIVoWngQFYTjco3EzG0If9uh+Y9606	rogid:vIlRg4sJ2oBiARNnyerGMaVr5ZU9606	rigid:8tpUyXHwkBU7O8tDbnyJqjm3YJM	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P78352	uniprotkb:P02794	intact:EBI-80389|ensembl:ENSP00000382425|intact:EBI-1760259|uniprotkb:Q92941|uniprotkb:Q9UKK8|intact:EBI-1965339|uniprotkb:B7Z1S1|uniprotkb:G5E939	intact:EBI-713259|uniprotkb:Q3KRA8|uniprotkb:Q3SWW1|ensembl:ENSP00000273550|ensembl:ENSP00000484477|uniprotkb:B3KNR5	psi-mi:dlg4_human(display_long)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)|uniprotkb:DLG4(gene name)|psi-mi:DLG4(display_short)|uniprotkb:PSD95(gene name synonym)	psi-mi:frih_human(display_long)|uniprotkb:Cell proliferation-inducing gene 15 protein(gene name synonym)|uniprotkb:FTH1(gene name)|psi-mi:FTH1(display_short)|uniprotkb:FTH(gene name synonym)|uniprotkb:FTHL6(gene name synonym)|uniprotkb:PIG15(orf name)|uniprotkb:OK/SW-cl.84(orf name)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509218|imex:IM-28561-1441	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000132535(gene)|ensembl:ENST00000399506(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007399"(nervous system development)|go:"GO:0007612"(learning)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019900"(kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:P78352|rcsb pdb:1KEF|rcsb pdb:2MES|rcsb pdb:3I4W|rcsb pdb:3K82|rcsb pdb:3ZRT|rcsb pdb:5J7J|rcsb pdb:5JXB|rcsb pdb:6QJD|rcsb pdb:6QJF|rcsb pdb:6QJG|rcsb pdb:6QJI|rcsb pdb:6QJJ|rcsb pdb:6QJK|rcsb pdb:6QJL|rcsb pdb:6QJN|rcsb pdb:6SPV|rcsb pdb:6SPZ|reactome:R-HSA-1236394|reactome:R-HSA-399719|reactome:R-HSA-438066|reactome:R-HSA-442982|reactome:R-HSA-447038|reactome:R-HSA-451308|reactome:R-HSA-5673001|reactome:R-HSA-5682910|reactome:R-HSA-6794361|reactome:R-HSA-8849932|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-5625900|reactome:R-HSA-9620244|refseq:NP_001308004.1|refseq:NP_001356.1|refseq:NP_001122299.1|dip:DIP-30919N	refseq:NP_002023.2|ensembl:ENSG00000167996(gene)|ensembl:ENST00000273550(transcript)|ensembl:ENST00000620041(transcript)|go:"GO:0004322"(ferroxidase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006826"(iron ion transport)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0006880"(intracellular sequestering of iron ion)|go:"GO:0006955"(immune response)|go:"GO:0008043"(intracellular ferritin complex)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008199"(ferric iron binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0044754"(autolysosome)|mint:P02794|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:1FHA|rcsb pdb:2CEI|rcsb pdb:2CHI|rcsb pdb:2CIH|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR001519(Ferritin, N-terminal)|interpro:IPR008331(Ferritin and Dps)|interpro:IPR009040(Ferritin-like)|interpro:IPR009078(Ferritin/ribonucleotide reductase-like)|interpro:IPR012347(Ferritin-related)|interpro:IPR014034(Ferritin, conserved site)|rcsb pdb:2CLU|rcsb pdb:2CN6|rcsb pdb:2CN7|rcsb pdb:2FHA|rcsb pdb:2IU2|rcsb pdb:2Z6M|rcsb pdb:3AJO|rcsb pdb:3AJP|rcsb pdb:3AJQ|rcsb pdb:3ERZ|rcsb pdb:3ES3|rcsb pdb:4DYX|rcsb pdb:4DYY|rcsb pdb:4DYZ|rcsb pdb:4Y08|rcsb pdb:4YKH|rcsb pdb:4ZJK|rcsb pdb:5CMQ|rcsb pdb:5CMR|rcsb pdb:5GN8|rcsb pdb:5GOU|rcsb pdb:5JKK|rcsb pdb:5JKL|rcsb pdb:5JKM|rcsb pdb:5N26|rcsb pdb:5N27|rcsb pdb:5UP7|rcsb pdb:5UP8|rcsb pdb:5UP9|rcsb pdb:5VTD|rcsb pdb:5XB1|rcsb pdb:5YI5|rcsb pdb:5ZND|rcsb pdb:6B8F|rcsb pdb:6B8G|rcsb pdb:4DZ0|rcsb pdb:6FTV|rcsb pdb:6GSR|rcsb pdb:6H5I|rcsb pdb:6H6T|rcsb pdb:6H6U|rcsb pdb:6IPC|rcsb pdb:6IPO|rcsb pdb:6IPP|rcsb pdb:6IPQ|rcsb pdb:6J4A|rcsb pdb:6J7G|rcsb pdb:6JOB|rcsb pdb:6JPS|rcsb pdb:6KE2|rcsb pdb:6KE4|rcsb pdb:4OYN|rcsb pdb:6M52|rcsb pdb:6M54|rcsb pdb:6WYF|rcsb pdb:6WYG|rcsb pdb:6WYH|rcsb pdb:6Z6U|rcsb pdb:6Z9E|rcsb pdb:6Z9F|rcsb pdb:7A6A|rcsb pdb:7A6B|rcsb pdb:7CK8|rcsb pdb:7CK9|rcsb pdb:7JGK|rcsb pdb:7JGL|rcsb pdb:7JGM|rcsb pdb:7JGN|rcsb pdb:7JGO|rcsb pdb:7JGP|rcsb pdb:7JGQ|rcsb pdb:7K26|rcsb pdb:7K3V|rcsb pdb:7K3W|reactome:R-HSA-3000480|reactome:R-HSA-432722|reactome:R-HSA-6798695|reactome:R-HSA-917937|dip:DIP-38301N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:VhIVoWngQFYTjco3EzG0If9uh+Y9606	rogid:TchHgRpv+inA8BQ5i0OHaa267tQ9606	rigid:F7y7FzVWhaR5Mi5fu0GMRB9WDk0	false	sufficient binding region:546-724	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P78352	uniprotkb:Q9Y2H0	intact:EBI-80389|ensembl:ENSP00000382425|intact:EBI-1760259|uniprotkb:Q92941|uniprotkb:Q9UKK8|intact:EBI-1965339|uniprotkb:B7Z1S1|uniprotkb:G5E939	intact:EBI-722139|uniprotkb:Q5QPG4|uniprotkb:Q5T2Y4|uniprotkb:Q5T2Y5|uniprotkb:Q9H137|uniprotkb:Q9H138|uniprotkb:Q9H1L7|uniprotkb:E1P5T5|ensembl:ENSP00000341633|ensembl:ENSP00000363014	psi-mi:dlg4_human(display_long)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)|uniprotkb:DLG4(gene name)|psi-mi:DLG4(display_short)|uniprotkb:PSD95(gene name synonym)	psi-mi:dlgp4_human(display_long)|uniprotkb:SAPAP4(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 4(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 4(gene name synonym)|uniprotkb:DLGAP4(gene name)|psi-mi:DLGAP4(display_short)|uniprotkb:DAP4(gene name synonym)|uniprotkb:KIAA0964(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509191|imex:IM-28561-463	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000132535(gene)|ensembl:ENST00000399506(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007399"(nervous system development)|go:"GO:0007612"(learning)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019900"(kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:P78352|rcsb pdb:1KEF|rcsb pdb:2MES|rcsb pdb:3I4W|rcsb pdb:3K82|rcsb pdb:3ZRT|rcsb pdb:5J7J|rcsb pdb:5JXB|rcsb pdb:6QJD|rcsb pdb:6QJF|rcsb pdb:6QJG|rcsb pdb:6QJI|rcsb pdb:6QJJ|rcsb pdb:6QJK|rcsb pdb:6QJL|rcsb pdb:6QJN|rcsb pdb:6SPV|rcsb pdb:6SPZ|reactome:R-HSA-1236394|reactome:R-HSA-399719|reactome:R-HSA-438066|reactome:R-HSA-442982|reactome:R-HSA-447038|reactome:R-HSA-451308|reactome:R-HSA-5673001|reactome:R-HSA-5682910|reactome:R-HSA-6794361|reactome:R-HSA-8849932|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-5625900|reactome:R-HSA-9620244|refseq:NP_001308004.1|refseq:NP_001356.1|refseq:NP_001122299.1|dip:DIP-30919N	refseq:NP_001035951.1|refseq:NP_055717.2|refseq:NP_892118.1|refseq:XP_011526990.1|ensembl:ENSG00000080845(gene)|ensembl:ENST00000339266(transcript)|ensembl:ENST00000373907(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0023052"(signaling)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098981"(cholinergic synapse)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030527|mint:Q9Y2H0|reactome:R-HSA-6794361	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:VhIVoWngQFYTjco3EzG0If9uh+Y9606	rogid:i9/U52HQi00xnRUtJN0VZ0oXXwY9606	rigid:CPcg5aXDJrSFma4j6km4Zv4NcMg	false	sufficient binding region:546-724	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P78352	uniprotkb:P00395	intact:EBI-80389|ensembl:ENSP00000382425|intact:EBI-1760259|uniprotkb:Q92941|uniprotkb:Q9UKK8|intact:EBI-1965339|uniprotkb:B7Z1S1|uniprotkb:G5E939	intact:EBI-2117234|uniprotkb:Q34770|ensembl:ENSP00000354499	psi-mi:dlg4_human(display_long)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)|uniprotkb:DLG4(gene name)|psi-mi:DLG4(display_short)|uniprotkb:PSD95(gene name synonym)	psi-mi:cox1_human(display_long)|uniprotkb:MT-CO1(gene name)|psi-mi:MT-CO1(display_short)|uniprotkb:COI(gene name synonym)|uniprotkb:COXI(gene name synonym)|uniprotkb:MTCO1(gene name synonym)|uniprotkb:Cytochrome c oxidase polypeptide I(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509284|imex:IM-28561-141	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000132535(gene)|ensembl:ENST00000399506(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007399"(nervous system development)|go:"GO:0007612"(learning)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019900"(kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:P78352|rcsb pdb:1KEF|rcsb pdb:2MES|rcsb pdb:3I4W|rcsb pdb:3K82|rcsb pdb:3ZRT|rcsb pdb:5J7J|rcsb pdb:5JXB|rcsb pdb:6QJD|rcsb pdb:6QJF|rcsb pdb:6QJG|rcsb pdb:6QJI|rcsb pdb:6QJJ|rcsb pdb:6QJK|rcsb pdb:6QJL|rcsb pdb:6QJN|rcsb pdb:6SPV|rcsb pdb:6SPZ|reactome:R-HSA-1236394|reactome:R-HSA-399719|reactome:R-HSA-438066|reactome:R-HSA-442982|reactome:R-HSA-447038|reactome:R-HSA-451308|reactome:R-HSA-5673001|reactome:R-HSA-5682910|reactome:R-HSA-6794361|reactome:R-HSA-8849932|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-5625900|reactome:R-HSA-9620244|refseq:NP_001308004.1|refseq:NP_001356.1|refseq:NP_001122299.1|dip:DIP-30919N	refseq:YP_003024028.1|ensembl:ENSG00000198804(gene)|ensembl:ENST00000361624(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005750"(mitochondrial respiratory chain complex III)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007568"(aging)|go:"GO:0009060"(aerobic respiration)|go:"GO:0015990"(electron transport coupled proton transport)|go:"GO:0020037"(heme binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0045277"(respiratory chain complex IV)|go:"GO:0046688"(response to copper ion)|go:"GO:0046872"(metal ion binding)|go:"GO:0051602"(response to electrical stimulus)|interpro:IPR000883(Cytochrome c oxidase, subunit I)|interpro:IPR023615|interpro:IPR023616|interpro:IPR033944|interpro:IPR036927|mint:P00395|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:VhIVoWngQFYTjco3EzG0If9uh+Y9606	rogid:hPHsY8UxxIWcLFkR9oIoZH5vtls9606	rigid:ulofpqcc/aY3B1+UE8eGYT7ckPo	false	sufficient binding region:546-724	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P78352	uniprotkb:Q00013	intact:EBI-80389|ensembl:ENSP00000382425|intact:EBI-1760259|uniprotkb:Q92941|uniprotkb:Q9UKK8|intact:EBI-1965339|uniprotkb:B7Z1S1|uniprotkb:G5E939	intact:EBI-711788|uniprotkb:B4DZV5|uniprotkb:Q5J7V5|uniprotkb:G3XAI1|uniprotkb:Q2TSB6|ensembl:ENSP00000358547	psi-mi:dlg4_human(display_long)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)|uniprotkb:DLG4(gene name)|psi-mi:DLG4(display_short)|uniprotkb:PSD95(gene name synonym)	psi-mi:em55_human(display_long)|uniprotkb:Membrane protein, palmitoylated 1(gene name synonym)|uniprotkb:MPP1(gene name)|psi-mi:MPP1(display_short)|uniprotkb:EMP55(gene name synonym)|uniprotkb:DXS552E(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509275|imex:IM-28561-581	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000132535(gene)|ensembl:ENST00000399506(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007399"(nervous system development)|go:"GO:0007612"(learning)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019900"(kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:P78352|rcsb pdb:1KEF|rcsb pdb:2MES|rcsb pdb:3I4W|rcsb pdb:3K82|rcsb pdb:3ZRT|rcsb pdb:5J7J|rcsb pdb:5JXB|rcsb pdb:6QJD|rcsb pdb:6QJF|rcsb pdb:6QJG|rcsb pdb:6QJI|rcsb pdb:6QJJ|rcsb pdb:6QJK|rcsb pdb:6QJL|rcsb pdb:6QJN|rcsb pdb:6SPV|rcsb pdb:6SPZ|reactome:R-HSA-1236394|reactome:R-HSA-399719|reactome:R-HSA-438066|reactome:R-HSA-442982|reactome:R-HSA-447038|reactome:R-HSA-451308|reactome:R-HSA-5673001|reactome:R-HSA-5682910|reactome:R-HSA-6794361|reactome:R-HSA-8849932|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-5625900|reactome:R-HSA-9620244|refseq:NP_001308004.1|refseq:NP_001356.1|refseq:NP_001122299.1|dip:DIP-30919N	refseq:NP_001159932.1|refseq:NP_001159933.1|refseq:NP_001159934.1|refseq:NP_002427.1|ensembl:ENSG00000130830(gene)|ensembl:ENST00000369534(transcript)|go:"GO:0004385"(guanylate kinase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0032420"(stereocilium)|go:"GO:0034451"(centriolar satellite)|go:"GO:0090022"(regulation of neutrophil chemotaxis)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR020590|interpro:IPR027417|interpro:IPR035475|interpro:IPR036028|interpro:IPR036034|mint:Q00013|rcsb pdb:2EJY|rcsb pdb:2EV8|rcsb pdb:3NEY|reactome:R-HSA-9662361	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:VhIVoWngQFYTjco3EzG0If9uh+Y9606	rogid:b9QmIlmQ5SZHnOQfGSezmcvaDls9606	rigid:ZuUh94AttIxeZ87MC7a4WMsiysY	false	sufficient binding region:298-550	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P78352	uniprotkb:Q9BRK4	intact:EBI-80389|ensembl:ENSP00000382425|intact:EBI-1760259|uniprotkb:Q92941|uniprotkb:Q9UKK8|intact:EBI-1965339|uniprotkb:B7Z1S1|uniprotkb:G5E939	intact:EBI-741037|ensembl:ENSP00000359240|ensembl:ENSP00000359243|uniprotkb:Q8N3I0|uniprotkb:Q96J79|uniprotkb:Q96JL2|uniprotkb:B1AL14|uniprotkb:D3DR72	psi-mi:dlg4_human(display_long)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)|uniprotkb:DLG4(gene name)|psi-mi:DLG4(display_short)|uniprotkb:PSD95(gene name synonym)	psi-mi:lzts2_human(display_long)|uniprotkb:Protein LAPSER1(gene name synonym)|uniprotkb:LZTS2(gene name)|psi-mi:LZTS2(display_short)|uniprotkb:KIAA1813(gene name synonym)|uniprotkb:LAPSER1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509259|imex:IM-28561-1021	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000132535(gene)|ensembl:ENST00000399506(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007399"(nervous system development)|go:"GO:0007612"(learning)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019900"(kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:P78352|rcsb pdb:1KEF|rcsb pdb:2MES|rcsb pdb:3I4W|rcsb pdb:3K82|rcsb pdb:3ZRT|rcsb pdb:5J7J|rcsb pdb:5JXB|rcsb pdb:6QJD|rcsb pdb:6QJF|rcsb pdb:6QJG|rcsb pdb:6QJI|rcsb pdb:6QJJ|rcsb pdb:6QJK|rcsb pdb:6QJL|rcsb pdb:6QJN|rcsb pdb:6SPV|rcsb pdb:6SPZ|reactome:R-HSA-1236394|reactome:R-HSA-399719|reactome:R-HSA-438066|reactome:R-HSA-442982|reactome:R-HSA-447038|reactome:R-HSA-451308|reactome:R-HSA-5673001|reactome:R-HSA-5682910|reactome:R-HSA-6794361|reactome:R-HSA-8849932|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-5625900|reactome:R-HSA-9620244|refseq:NP_001308004.1|refseq:NP_001356.1|refseq:NP_001122299.1|dip:DIP-30919N	refseq:NP_115805.1|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030496"(midbody)|go:"GO:0031982"(vesicle)|go:"GO:0051013"(microtubule severing)|go:"GO:0051168"(nuclear export)|go:"GO:0051255"(spindle midzone assembly)|go:"GO:0060682"(primary ureteric bud growth)|go:"GO:0072197"(ureter morphogenesis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|interpro:IPR028597|mint:Q9BRK4|ensembl:ENSG00000107816(gene)|ensembl:ENST00000370220(transcript)|ensembl:ENST00000370223(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0008285"(negative regulation of cell population proliferation)|refseq:XP_016872269.1|refseq:NP_001305028.1|refseq:NP_001305029.1|refseq:NP_001305030.1|refseq:XP_005270279.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:VhIVoWngQFYTjco3EzG0If9uh+Y9606	rogid:OaMJmnmfm6JniKUJeyg7fS6zRcw9606	rigid:o99gBunybJzAAza0/TDXFVI3h48	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P78352	uniprotkb:Q8N594	intact:EBI-80389|ensembl:ENSP00000382425|intact:EBI-1760259|uniprotkb:Q92941|uniprotkb:Q9UKK8|intact:EBI-1965339|uniprotkb:B7Z1S1|uniprotkb:G5E939	intact:EBI-2512452|ensembl:ENSP00000262966|uniprotkb:Q96SJ0|uniprotkb:Q9Y2P1|uniprotkb:Q9Y2P2	psi-mi:dlg4_human(display_long)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)|uniprotkb:DLG4(gene name)|psi-mi:DLG4(display_short)|uniprotkb:PSD95(gene name synonym)	psi-mi:mpnd_human(display_long)|uniprotkb:MPND(gene name)|psi-mi:MPND(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509266|imex:IM-28561-1701	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000132535(gene)|ensembl:ENST00000399506(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007399"(nervous system development)|go:"GO:0007612"(learning)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019900"(kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:P78352|rcsb pdb:1KEF|rcsb pdb:2MES|rcsb pdb:3I4W|rcsb pdb:3K82|rcsb pdb:3ZRT|rcsb pdb:5J7J|rcsb pdb:5JXB|rcsb pdb:6QJD|rcsb pdb:6QJF|rcsb pdb:6QJG|rcsb pdb:6QJI|rcsb pdb:6QJJ|rcsb pdb:6QJK|rcsb pdb:6QJL|rcsb pdb:6QJN|rcsb pdb:6SPV|rcsb pdb:6SPZ|reactome:R-HSA-1236394|reactome:R-HSA-399719|reactome:R-HSA-438066|reactome:R-HSA-442982|reactome:R-HSA-447038|reactome:R-HSA-451308|reactome:R-HSA-5673001|reactome:R-HSA-5682910|reactome:R-HSA-6794361|reactome:R-HSA-8849932|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-5625900|reactome:R-HSA-9620244|refseq:NP_001308004.1|refseq:NP_001356.1|refseq:NP_001122299.1|dip:DIP-30919N	ensembl:ENSG00000008382(gene)|ensembl:ENST00000262966(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0042393"(histone binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0070122"(isopeptidase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR037518|interpro:IPR040843|mint:Q8N594|refseq:NP_001153318.1|refseq:NP_116257.2	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:VhIVoWngQFYTjco3EzG0If9uh+Y9606	rogid:pkgiV58o6A8/jxIH3+E5PnhvrXk9606	rigid:cdVV0QJ9Z5Hv5yK54+0IMy/GLxA	false	sufficient binding region:546-724	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P78352	uniprotkb:P26641	intact:EBI-80389|ensembl:ENSP00000382425|intact:EBI-1760259|uniprotkb:Q92941|uniprotkb:Q9UKK8|intact:EBI-1965339|uniprotkb:B7Z1S1|uniprotkb:G5E939	intact:EBI-351467|uniprotkb:Q6PJ62|uniprotkb:Q6PK31|uniprotkb:Q96CU2|uniprotkb:Q9P196|intact:EBI-2321928|uniprotkb:B4DTG2|ensembl:ENSP00000331901	psi-mi:dlg4_human(display_long)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)|uniprotkb:DLG4(gene name)|psi-mi:DLG4(display_short)|uniprotkb:PSD95(gene name synonym)	psi-mi:ef1g_human(display_long)|uniprotkb:PRO1608(orf name)|uniprotkb:EEF1G(gene name)|psi-mi:EEF1G(display_short)|uniprotkb:EF1G(gene name synonym)|uniprotkb:eEF-1B gamma(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509200|imex:IM-28561-1621	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000132535(gene)|ensembl:ENST00000399506(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007399"(nervous system development)|go:"GO:0007612"(learning)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019900"(kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:P78352|rcsb pdb:1KEF|rcsb pdb:2MES|rcsb pdb:3I4W|rcsb pdb:3K82|rcsb pdb:3ZRT|rcsb pdb:5J7J|rcsb pdb:5JXB|rcsb pdb:6QJD|rcsb pdb:6QJF|rcsb pdb:6QJG|rcsb pdb:6QJI|rcsb pdb:6QJJ|rcsb pdb:6QJK|rcsb pdb:6QJL|rcsb pdb:6QJN|rcsb pdb:6SPV|rcsb pdb:6SPZ|reactome:R-HSA-1236394|reactome:R-HSA-399719|reactome:R-HSA-438066|reactome:R-HSA-442982|reactome:R-HSA-447038|reactome:R-HSA-451308|reactome:R-HSA-5673001|reactome:R-HSA-5682910|reactome:R-HSA-6794361|reactome:R-HSA-8849932|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-5625900|reactome:R-HSA-9620244|refseq:NP_001308004.1|refseq:NP_001356.1|refseq:NP_001122299.1|dip:DIP-30919N	refseq:NP_001395.1|ensembl:ENSG00000254772(gene)|ensembl:ENST00000329251(transcript)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006414"(translational elongation)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0009615"(response to virus)|go:"GO:0016020"(membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001662(Translation elongation factor EF1B, gamma chain, conserved)|interpro:IPR004045(Glutathione S-transferase, N-terminal)|interpro:IPR004046(Glutathione S-transferase, C-terminal)|interpro:IPR010987(Glutathione S-transferase, C-terminal-like)|interpro:IPR036249|interpro:IPR036282|interpro:IPR036433|interpro:IPR040079|mint:P26641|rcsb pdb:1PBU|rcsb pdb:5DQS|rcsb pdb:5JPO|reactome:R-HSA-156842|dip:DIP-32516N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:VhIVoWngQFYTjco3EzG0If9uh+Y9606	rogid:biVN96umeEdPm/wvPN4VwbSRHTs9606	rigid:+lQtkhFQWjqzOFLhmCb5axpsSc4	false	sufficient binding region:546-724	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P78352	uniprotkb:Q96GS6	intact:EBI-80389|ensembl:ENSP00000382425|intact:EBI-1760259|uniprotkb:Q92941|uniprotkb:Q9UKK8|intact:EBI-1965339|uniprotkb:B7Z1S1|uniprotkb:G5E939	intact:EBI-2870273|uniprotkb:Q6PJU2|uniprotkb:A8K0G8|uniprotkb:Q9BWL0|uniprotkb:Q8WUH9|uniprotkb:Q9H7Q9|uniprotkb:D6W5Z9|ensembl:ENSP00000292577|ensembl:ENSP00000504042	psi-mi:dlg4_human(display_long)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)|uniprotkb:DLG4(gene name)|psi-mi:DLG4(display_short)|uniprotkb:PSD95(gene name synonym)	psi-mi:ab17a_human(display_long)|uniprotkb:ABHD17A(gene name)|psi-mi:ABHD17A(display_short)|uniprotkb:C19orf27(gene name synonym)|uniprotkb:FAM108A1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509209|imex:IM-28561-741	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000132535(gene)|ensembl:ENST00000399506(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007399"(nervous system development)|go:"GO:0007612"(learning)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019900"(kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:P78352|rcsb pdb:1KEF|rcsb pdb:2MES|rcsb pdb:3I4W|rcsb pdb:3K82|rcsb pdb:3ZRT|rcsb pdb:5J7J|rcsb pdb:5JXB|rcsb pdb:6QJD|rcsb pdb:6QJF|rcsb pdb:6QJG|rcsb pdb:6QJI|rcsb pdb:6QJJ|rcsb pdb:6QJK|rcsb pdb:6QJL|rcsb pdb:6QJN|rcsb pdb:6SPV|rcsb pdb:6SPZ|reactome:R-HSA-1236394|reactome:R-HSA-399719|reactome:R-HSA-438066|reactome:R-HSA-442982|reactome:R-HSA-447038|reactome:R-HSA-451308|reactome:R-HSA-5673001|reactome:R-HSA-5682910|reactome:R-HSA-6794361|reactome:R-HSA-8849932|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-5625900|reactome:R-HSA-9620244|refseq:NP_001308004.1|refseq:NP_001356.1|refseq:NP_001122299.1|dip:DIP-30919N	refseq:XP_011526640.1|refseq:XP_016882830.1|refseq:NP_001123583.1|refseq:NP_112490.3|ensembl:ENSG00000129968(gene)|ensembl:ENST00000292577(transcript)|ensembl:ENST00000676686(transcript)|go:"GO:0002084"(protein depalmitoylation)|go:"GO:0005886"(plasma membrane)|go:"GO:0008474"("palmitoyl-(protein) hydrolase activity")|go:"GO:0010008"(endosome membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099033"(anchored component of postsynaptic recycling endosome membrane)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:1902817"(negative regulation of protein localization to microtubule)|go:"GO:1905668"(positive regulation of protein localization to endosome)|interpro:IPR022742|interpro:IPR029058|mint:Q96GS6|reactome:R-HSA-9648002|go:"GO:0016020"(membrane)	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:VhIVoWngQFYTjco3EzG0If9uh+Y9606	rogid:eZ6J8YENMgDhwA9IrEscvsGst+w9606	rigid:vGFivr4Zm4JpDYoeatt3xJP21hw	false	sufficient binding region:298-550	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P26358	uniprotkb:P30086	intact:EBI-719459|uniprotkb:Q9UHG5|uniprotkb:Q9ULA2|uniprotkb:Q9UMZ6|uniprotkb:A0AV63|intact:EBI-28971395|ensembl:ENSP00000345739|uniprotkb:B7ZLW6	intact:EBI-716384|uniprotkb:B2R4S1|ensembl:ENSP00000261313	psi-mi:dnmt1_human(display_long)|uniprotkb:CXXC9(gene name synonym)|uniprotkb:MCMT(gene name synonym)|uniprotkb:DNA methyltransferase HsaI(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 9(gene name synonym)|uniprotkb:DNMT1(gene name)|psi-mi:DNMT1(display_short)|uniprotkb:AIM(gene name synonym)|uniprotkb:DNMT(gene name synonym)	psi-mi:pebp1_human(display_long)|uniprotkb:Prostatic-binding protein(gene name synonym)|uniprotkb:HCNPpp(gene name synonym)|uniprotkb:Neuropolypeptide h3(gene name synonym)|uniprotkb:Raf kinase inhibitor protein(gene name synonym)|uniprotkb:PEBP1(gene name)|psi-mi:PEBP1(display_short)|uniprotkb:PEBP(gene name synonym)|uniprotkb:PBP(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509479|imex:IM-28561-1521	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000345739|ensembl:ENST00000359526|ensembl:ENSP00000352516|refseq:NP_001124295.1|refseq:NP_001370.1|ensembl:ENSG00000130816(gene)|ensembl:ENST00000340748(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003886"("DNA (cytosine-5-)-methyltransferase activity")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0006306"(DNA methylation)|go:"GO:0006325"(chromatin organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008270"(zinc ion binding)|reactome:R-HSA-427413|reactome:R-HSA-4655427|reactome:R-HSA-5334118|reactome:R-HSA-9710421|refseq:NP_001305659.1|refseq:NP_001305660.1|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0009008"(DNA-methyltransferase activity)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016458"(obsolete gene silencing)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051573"(negative regulation of histone H3-K9 methylation)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0090309"(positive regulation of DNA methylation-dependent heterochromatin assembly)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905460"(negative regulation of vascular associated smooth muscle cell apoptotic process)|go:"GO:1905931"(negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR001525(C-5 cytosine-specific DNA methylase)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR010506(DMAP1-binding)|interpro:IPR017198("DNA (cytosine-5)-methyltransferase 1")|interpro:IPR018117|interpro:IPR022702|interpro:IPR029063|interpro:IPR031303|interpro:IPR043151|mint:P26358|rcsb pdb:3EPZ|rcsb pdb:3PTA|rcsb pdb:3SWR|rcsb pdb:4WXX|rcsb pdb:4YOC|rcsb pdb:4Z96|rcsb pdb:4Z97|rcsb pdb:5WVO|rcsb pdb:5YDR|rcsb pdb:6K3A|reactome:R-HSA-212300|dip:DIP-39693N	refseq:NP_002558.1|ensembl:ENSG00000089220(gene)|ensembl:ENST00000261313(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0008429"(phosphatidylethanolamine binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001858(Phosphatidylethanolamine-binding, conserved site)|interpro:IPR008914(Phosphatidylethanolamine-binding protein PEBP)|interpro:IPR035810|interpro:IPR036610|mint:P30086|rcsb pdb:1BD9|rcsb pdb:1BEH|rcsb pdb:2L7W|rcsb pdb:2QYQ|reactome:R-HSA-5674135|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|dip:DIP-44269N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:qae3zQwGP5R/+WCWoeahDKZ/9Jg9606	rogid:6NY/YmyO5c8tNYfXtujwvP2chIc9606	rigid:LV5nScUwGqyZbT8SgMJs3xUK35o	false	sufficient binding region:245-446	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P26358	uniprotkb:Q8IXK0	intact:EBI-719459|uniprotkb:Q9UHG5|uniprotkb:Q9ULA2|uniprotkb:Q9UMZ6|uniprotkb:A0AV63|intact:EBI-28971395|ensembl:ENSP00000345739|uniprotkb:B7ZLW6	intact:EBI-713786|uniprotkb:Q8N306|uniprotkb:Q8TAG8|uniprotkb:A1L4Q1|uniprotkb:Q2TAL3|uniprotkb:Q5T0C1|uniprotkb:Q6NUJ6|uniprotkb:Q6ZQR1|uniprotkb:Q96BL4|uniprotkb:Q9Y4Y7|ensembl:ENSP00000257118|uniprotkb:D3DPR2|uniprotkb:A8KA40	psi-mi:dnmt1_human(display_long)|uniprotkb:CXXC9(gene name synonym)|uniprotkb:MCMT(gene name synonym)|uniprotkb:DNA methyltransferase HsaI(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 9(gene name synonym)|uniprotkb:DNMT1(gene name)|psi-mi:DNMT1(display_short)|uniprotkb:AIM(gene name synonym)|uniprotkb:DNMT(gene name synonym)	psi-mi:phc2_human(display_long)|uniprotkb:Early development regulatory protein 2(gene name synonym)|uniprotkb:PHC2(gene name)|psi-mi:PHC2(display_short)|uniprotkb:EDR2(gene name synonym)|uniprotkb:PH2(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509488|imex:IM-28561-1523	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000345739|ensembl:ENST00000359526|ensembl:ENSP00000352516|refseq:NP_001124295.1|refseq:NP_001370.1|ensembl:ENSG00000130816(gene)|ensembl:ENST00000340748(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003886"("DNA (cytosine-5-)-methyltransferase activity")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0006306"(DNA methylation)|go:"GO:0006325"(chromatin organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008270"(zinc ion binding)|reactome:R-HSA-427413|reactome:R-HSA-4655427|reactome:R-HSA-5334118|reactome:R-HSA-9710421|refseq:NP_001305659.1|refseq:NP_001305660.1|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0009008"(DNA-methyltransferase activity)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016458"(obsolete gene silencing)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051573"(negative regulation of histone H3-K9 methylation)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0090309"(positive regulation of DNA methylation-dependent heterochromatin assembly)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905460"(negative regulation of vascular associated smooth muscle cell apoptotic process)|go:"GO:1905931"(negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR001525(C-5 cytosine-specific DNA methylase)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR010506(DMAP1-binding)|interpro:IPR017198("DNA (cytosine-5)-methyltransferase 1")|interpro:IPR018117|interpro:IPR022702|interpro:IPR029063|interpro:IPR031303|interpro:IPR043151|mint:P26358|rcsb pdb:3EPZ|rcsb pdb:3PTA|rcsb pdb:3SWR|rcsb pdb:4WXX|rcsb pdb:4YOC|rcsb pdb:4Z96|rcsb pdb:4Z97|rcsb pdb:5WVO|rcsb pdb:5YDR|rcsb pdb:6K3A|reactome:R-HSA-212300|dip:DIP-39693N	interpro:IPR038603|mint:Q8IXK0|reactome:R-HSA-2559580|reactome:R-HSA-3108214|reactome:R-HSA-3899300|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4655427|reactome:R-HSA-8939243|reactome:R-HSA-8943724|interpro:IPR013761(Sterile alpha motif-type)|ensembl:ENSG00000134686(gene)|ensembl:ENST00000257118(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0031519"(PcG protein complex)|go:"GO:0035102"(PRC1 complex)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR012313(Zinc finger, FCS-type)|refseq:NP_004418.2|refseq:NP_932157.1|refseq:XP_016856005.1|refseq:XP_016856006.1|refseq:XP_016856007.1|refseq:XP_005270627.1|dip:DIP-34464N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:qae3zQwGP5R/+WCWoeahDKZ/9Jg9606	rogid:7si/KU2tHoxviuCr70ncQERDWmY9606	rigid:2opCvukptFHwvlYMKZZETKzlG3s	false	sufficient binding region:245-446	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P26358	uniprotkb:C9JLW8	intact:EBI-719459|uniprotkb:Q9UHG5|uniprotkb:Q9ULA2|uniprotkb:Q9UMZ6|uniprotkb:A0AV63|intact:EBI-28971395|ensembl:ENSP00000345739|uniprotkb:B7ZLW6	intact:EBI-11599148|uniprotkb:Q6ZUL0|ensembl:ENSP00000409009|ensembl:ENSP00000445543|ensembl:ENSP00000458707|ensembl:ENSP00000458720|ensembl:ENSP00000499966|ensembl:ENSP00000500382|ensembl:ENSP00000500493|ensembl:ENSP00000500656	psi-mi:dnmt1_human(display_long)|uniprotkb:CXXC9(gene name synonym)|uniprotkb:MCMT(gene name synonym)|uniprotkb:DNA methyltransferase HsaI(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 9(gene name synonym)|uniprotkb:DNMT1(gene name)|psi-mi:DNMT1(display_short)|uniprotkb:AIM(gene name synonym)|uniprotkb:DNMT(gene name synonym)	psi-mi:mcri1_human(display_long)|uniprotkb:MCRIP1(gene name)|psi-mi:MCRIP1(display_short)|uniprotkb:FAM195B(gene name synonym)|uniprotkb:GRAN2(gene name synonym)|uniprotkb:Granulin-2(gene name synonym)|uniprotkb:Protein FAM195B(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509461|imex:IM-28561-1285	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000345739|ensembl:ENST00000359526|ensembl:ENSP00000352516|refseq:NP_001124295.1|refseq:NP_001370.1|ensembl:ENSG00000130816(gene)|ensembl:ENST00000340748(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003886"("DNA (cytosine-5-)-methyltransferase activity")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0006306"(DNA methylation)|go:"GO:0006325"(chromatin organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008270"(zinc ion binding)|reactome:R-HSA-427413|reactome:R-HSA-4655427|reactome:R-HSA-5334118|reactome:R-HSA-9710421|refseq:NP_001305659.1|refseq:NP_001305660.1|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0009008"(DNA-methyltransferase activity)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016458"(obsolete gene silencing)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051573"(negative regulation of histone H3-K9 methylation)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0090309"(positive regulation of DNA methylation-dependent heterochromatin assembly)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905460"(negative regulation of vascular associated smooth muscle cell apoptotic process)|go:"GO:1905931"(negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR001525(C-5 cytosine-specific DNA methylase)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR010506(DMAP1-binding)|interpro:IPR017198("DNA (cytosine-5)-methyltransferase 1")|interpro:IPR018117|interpro:IPR022702|interpro:IPR029063|interpro:IPR031303|interpro:IPR043151|mint:P26358|rcsb pdb:3EPZ|rcsb pdb:3PTA|rcsb pdb:3SWR|rcsb pdb:4WXX|rcsb pdb:4YOC|rcsb pdb:4Z96|rcsb pdb:4Z97|rcsb pdb:5WVO|rcsb pdb:5YDR|rcsb pdb:6K3A|reactome:R-HSA-212300|dip:DIP-39693N	refseq:NP_001087236.1|refseq:NP_997251.2|ensembl:ENST00000673154(transcript)|ensembl:ENST00000673369(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|interpro:IPR029428|mint:C9JLW8|ensembl:ENSG00000225663(gene)|ensembl:ENSG00000288213(gene)|ensembl:ENST00000455127(transcript)|ensembl:ENST00000538396(transcript)|ensembl:ENST00000574190(transcript)|ensembl:ENST00000576730(transcript)|ensembl:ENST00000672201(transcript)|ensembl:ENST00000672501(transcript)	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:qae3zQwGP5R/+WCWoeahDKZ/9Jg9606	rogid:iZOqcqhEDT2q90EsGR+8S8Oef809606	rigid:viVSZvIOBmVGtqwBiYL6CJwtF6Q	false	sufficient binding region:245-446	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P26358	uniprotkb:O43768	intact:EBI-719459|uniprotkb:Q9UHG5|uniprotkb:Q9ULA2|uniprotkb:Q9UMZ6|uniprotkb:A0AV63|intact:EBI-28971395|ensembl:ENSP00000345739|uniprotkb:B7ZLW6	intact:EBI-714511|uniprotkb:Q9NRZ0|uniprotkb:A8K1Z9|uniprotkb:Q5T5H2|uniprotkb:Q68D48|uniprotkb:Q6FHW0|uniprotkb:Q6IAM4|uniprotkb:Q6NUL2|uniprotkb:Q6VUC6|uniprotkb:Q6VUC7|uniprotkb:Q6VUC8|uniprotkb:Q6VUC9|uniprotkb:Q6VUD0|uniprotkb:Q6VUD1|intact:EBI-3385389|ensembl:ENSP00000358010|uniprotkb:E9PB69	psi-mi:dnmt1_human(display_long)|uniprotkb:CXXC9(gene name synonym)|uniprotkb:MCMT(gene name synonym)|uniprotkb:DNA methyltransferase HsaI(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 9(gene name synonym)|uniprotkb:DNMT1(gene name)|psi-mi:DNMT1(display_short)|uniprotkb:AIM(gene name synonym)|uniprotkb:DNMT(gene name synonym)	psi-mi:ensa_human(display_long)|uniprotkb:ARPP-19e(gene name synonym)|uniprotkb:ENSA(gene name)|psi-mi:ENSA(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509452|imex:IM-28561-1763	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000345739|ensembl:ENST00000359526|ensembl:ENSP00000352516|refseq:NP_001124295.1|refseq:NP_001370.1|ensembl:ENSG00000130816(gene)|ensembl:ENST00000340748(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003886"("DNA (cytosine-5-)-methyltransferase activity")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0006306"(DNA methylation)|go:"GO:0006325"(chromatin organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008270"(zinc ion binding)|reactome:R-HSA-427413|reactome:R-HSA-4655427|reactome:R-HSA-5334118|reactome:R-HSA-9710421|refseq:NP_001305659.1|refseq:NP_001305660.1|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0009008"(DNA-methyltransferase activity)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016458"(obsolete gene silencing)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051573"(negative regulation of histone H3-K9 methylation)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0090309"(positive regulation of DNA methylation-dependent heterochromatin assembly)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905460"(negative regulation of vascular associated smooth muscle cell apoptotic process)|go:"GO:1905931"(negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR001525(C-5 cytosine-specific DNA methylase)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR010506(DMAP1-binding)|interpro:IPR017198("DNA (cytosine-5)-methyltransferase 1")|interpro:IPR018117|interpro:IPR022702|interpro:IPR029063|interpro:IPR031303|interpro:IPR043151|mint:P26358|rcsb pdb:3EPZ|rcsb pdb:3PTA|rcsb pdb:3SWR|rcsb pdb:4WXX|rcsb pdb:4YOC|rcsb pdb:4Z96|rcsb pdb:4Z97|rcsb pdb:5WVO|rcsb pdb:5YDR|rcsb pdb:6K3A|reactome:R-HSA-212300|dip:DIP-39693N	refseq:NP_004427.1|go:"GO:0007584"(response to nutrient)|go:"GO:0008200"(ion channel inhibitor activity)|go:"GO:0009749"(response to glucose)|go:"GO:0019212"(phosphatase inhibitor activity)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051301"(cell division)|go:"GO:0051721"(protein phosphatase 2A binding)|interpro:IPR006760(cAMP-regulated phosphoprotein/endosulphine conserved region)|mint:O43768|reactome:R-HSA-2465910|go:"GO:0005737"(cytoplasm)|refseq:NP_996925.1|refseq:NP_996926.1|refseq:NP_996927.1|refseq:NP_996928.1|refseq:NP_996929.1|refseq:NP_996930.1|refseq:NP_997051.1|ensembl:ENSG00000143420(gene)|ensembl:ENST00000369014(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004864"(protein phosphatase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005654"(nucleoplasm)	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:qae3zQwGP5R/+WCWoeahDKZ/9Jg9606	rogid:brEq+JKnHvwd8+2HXiVatUdta2U9606	rigid:4C2e9eHj94V2KmW8bBo9nKkOsk0	false	sufficient binding region:245-446	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P26358	uniprotkb:P68104	intact:EBI-719459|uniprotkb:Q9UHG5|uniprotkb:Q9ULA2|uniprotkb:Q9UMZ6|uniprotkb:A0AV63|intact:EBI-28971395|ensembl:ENSP00000345739|uniprotkb:B7ZLW6	intact:EBI-352162|uniprotkb:P04719|uniprotkb:P04720|intact:EBI-2834776|intact:EBI-8011754|intact:MINT-4903558|uniprotkb:Q6IQ15|ensembl:ENSP00000330054|ensembl:ENSP00000339053|ensembl:ENSP00000339063|ensembl:ENSP00000348651|ensembl:ENSP00000392366|ensembl:ENSP00000479055|ensembl:ENSP00000503192|ensembl:ENSP00000503249|ensembl:ENSP00000503823|ensembl:ENSP00000504335|intact:EBI-16423274	psi-mi:dnmt1_human(display_long)|uniprotkb:CXXC9(gene name synonym)|uniprotkb:MCMT(gene name synonym)|uniprotkb:DNA methyltransferase HsaI(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 9(gene name synonym)|uniprotkb:DNMT1(gene name)|psi-mi:DNMT1(display_short)|uniprotkb:AIM(gene name synonym)|uniprotkb:DNMT(gene name synonym)	psi-mi:ef1a1_human(display_long)|uniprotkb:EEF1A1(gene name)|psi-mi:EEF1A1(display_short)|uniprotkb:EEF1A(gene name synonym)|uniprotkb:EF1A(gene name synonym)|uniprotkb:LENG7(gene name synonym)|uniprotkb:Eukaryotic elongation factor 1 A-1(gene name synonym)|uniprotkb:Elongation factor Tu(gene name synonym)|uniprotkb:Leukocyte receptor cluster member 7(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509443|imex:IM-28561-1761	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000345739|ensembl:ENST00000359526|ensembl:ENSP00000352516|refseq:NP_001124295.1|refseq:NP_001370.1|ensembl:ENSG00000130816(gene)|ensembl:ENST00000340748(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003886"("DNA (cytosine-5-)-methyltransferase activity")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0006306"(DNA methylation)|go:"GO:0006325"(chromatin organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008270"(zinc ion binding)|reactome:R-HSA-427413|reactome:R-HSA-4655427|reactome:R-HSA-5334118|reactome:R-HSA-9710421|refseq:NP_001305659.1|refseq:NP_001305660.1|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0009008"(DNA-methyltransferase activity)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016458"(obsolete gene silencing)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051573"(negative regulation of histone H3-K9 methylation)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0090309"(positive regulation of DNA methylation-dependent heterochromatin assembly)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905460"(negative regulation of vascular associated smooth muscle cell apoptotic process)|go:"GO:1905931"(negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR001525(C-5 cytosine-specific DNA methylase)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR010506(DMAP1-binding)|interpro:IPR017198("DNA (cytosine-5)-methyltransferase 1")|interpro:IPR018117|interpro:IPR022702|interpro:IPR029063|interpro:IPR031303|interpro:IPR043151|mint:P26358|rcsb pdb:3EPZ|rcsb pdb:3PTA|rcsb pdb:3SWR|rcsb pdb:4WXX|rcsb pdb:4YOC|rcsb pdb:4Z96|rcsb pdb:4Z97|rcsb pdb:5WVO|rcsb pdb:5YDR|rcsb pdb:6K3A|reactome:R-HSA-212300|dip:DIP-39693N	refseq:XP_011533816.1|ensembl:ENSG00000156508(gene)|ensembl:ENST00000309268(transcript)|ensembl:ENST00000316292(transcript)|ensembl:ENST00000331523(transcript)|ensembl:ENST00000356303(transcript)|ensembl:ENST00000455918(transcript)|ensembl:ENST00000615060(transcript)|ensembl:ENST00000676710(transcript)|ensembl:ENST00000677236(transcript)|ensembl:ENST00000678508(transcript)|ensembl:ENST00000678702(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0005853"(eukaryotic translation elongation factor 1 complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0006412"(translation)|go:"GO:0006414"(translational elongation)|go:"GO:0016020"(membrane)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0032587"(ruffle membrane)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0098574"(cytoplasmic side of lysosomal membrane)|go:"GO:1900022"(regulation of D-erythro-sphingosine kinase activity)|go:"GO:1904714"(regulation of chaperone-mediated autophagy)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004160(Translation elongation factor EFTu/EF1A, C-terminal)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR004539(Translation elongation factor EF1A, eukaryotic and archaeal)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR009001(Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal)|interpro:IPR027417|interpro:IPR031157|mint:P68104|rcsb pdb:1SYW|rcsb pdb:3C5J|rcsb pdb:6ZMO|reactome:R-HSA-156842|reactome:R-HSA-156902|reactome:R-HSA-3371511|reactome:R-HSA-6798695|reactome:R-HSA-8876725|reactome:R-HSA-9613829|dip:DIP-31277N|refseq:NP_001393.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:qae3zQwGP5R/+WCWoeahDKZ/9Jg9606	rogid:d3REF87FDKboAjyvlJJEXtqhrcw9606	rigid:B+JfneJQ0zeSxpR2CbSJGj8lFso	false	sufficient binding region:245-446	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P78352	uniprotkb:Q6RFH5	intact:EBI-80389|ensembl:ENSP00000382425|intact:EBI-1760259|uniprotkb:Q92941|uniprotkb:Q9UKK8|intact:EBI-1965339|uniprotkb:B7Z1S1|uniprotkb:G5E939	intact:EBI-722366|uniprotkb:Q9BRC9|uniprotkb:Q9H6X8|uniprotkb:Q9NVY2|uniprotkb:A8K8G5|ensembl:ENSP00000278856|ensembl:ENSP00000432119|ensembl:ENSP00000435726	psi-mi:dlg4_human(display_long)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)|uniprotkb:DLG4(gene name)|psi-mi:DLG4(display_short)|uniprotkb:PSD95(gene name synonym)	psi-mi:wdr74_human(display_long)|uniprotkb:NOP seven-associated protein 1(gene name synonym)|uniprotkb:WDR74(gene name)|psi-mi:WDR74(display_short)|uniprotkb:NSA1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509434|imex:IM-28561-187	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000132535(gene)|ensembl:ENST00000399506(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007399"(nervous system development)|go:"GO:0007612"(learning)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019900"(kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:P78352|rcsb pdb:1KEF|rcsb pdb:2MES|rcsb pdb:3I4W|rcsb pdb:3K82|rcsb pdb:3ZRT|rcsb pdb:5J7J|rcsb pdb:5JXB|rcsb pdb:6QJD|rcsb pdb:6QJF|rcsb pdb:6QJG|rcsb pdb:6QJI|rcsb pdb:6QJJ|rcsb pdb:6QJK|rcsb pdb:6QJL|rcsb pdb:6QJN|rcsb pdb:6SPV|rcsb pdb:6SPZ|reactome:R-HSA-1236394|reactome:R-HSA-399719|reactome:R-HSA-438066|reactome:R-HSA-442982|reactome:R-HSA-447038|reactome:R-HSA-451308|reactome:R-HSA-5673001|reactome:R-HSA-5682910|reactome:R-HSA-6794361|reactome:R-HSA-8849932|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-5625900|reactome:R-HSA-9620244|refseq:NP_001308004.1|refseq:NP_001356.1|refseq:NP_001122299.1|dip:DIP-30919N	refseq:NP_060563.2|refseq:XP_005274112.1|refseq:NP_001294906.1|ensembl:ENSG00000133316(gene)|ensembl:ENST00000278856(transcript)|ensembl:ENST00000525239(transcript)|ensembl:ENST00000529106(transcript)|go:"GO:0001825"(blastocyst formation)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006364"(rRNA processing)|go:"GO:0016070"(RNA metabolic process)|go:"GO:0030687"(preribosome, large subunit precursor)|go:"GO:0042273"(ribosomal large subunit biogenesis)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|interpro:IPR037379|mint:Q6RFH5	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:VhIVoWngQFYTjco3EzG0If9uh+Y9606	rogid:KGh4kcZ85zi1yj6Ow10pW3h7ECM9606	rigid:L77l/XBHKqIPyHfvmFdnuU7fTuE	false	sufficient binding region:546-724	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P78352	uniprotkb:Q2NL98	intact:EBI-80389|ensembl:ENSP00000382425|intact:EBI-1760259|uniprotkb:Q92941|uniprotkb:Q9UKK8|intact:EBI-1965339|uniprotkb:B7Z1S1|uniprotkb:G5E939	intact:EBI-2803134|uniprotkb:B3KW55|ensembl:ENSP00000343348	psi-mi:dlg4_human(display_long)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)|uniprotkb:DLG4(gene name)|psi-mi:DLG4(display_short)|uniprotkb:PSD95(gene name synonym)	psi-mi:vmac_human(display_long)|uniprotkb:VMAC(gene name)|psi-mi:VMAC(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509425|imex:IM-28561-1061	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000132535(gene)|ensembl:ENST00000399506(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007399"(nervous system development)|go:"GO:0007612"(learning)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019900"(kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:P78352|rcsb pdb:1KEF|rcsb pdb:2MES|rcsb pdb:3I4W|rcsb pdb:3K82|rcsb pdb:3ZRT|rcsb pdb:5J7J|rcsb pdb:5JXB|rcsb pdb:6QJD|rcsb pdb:6QJF|rcsb pdb:6QJG|rcsb pdb:6QJI|rcsb pdb:6QJJ|rcsb pdb:6QJK|rcsb pdb:6QJL|rcsb pdb:6QJN|rcsb pdb:6SPV|rcsb pdb:6SPZ|reactome:R-HSA-1236394|reactome:R-HSA-399719|reactome:R-HSA-438066|reactome:R-HSA-442982|reactome:R-HSA-447038|reactome:R-HSA-451308|reactome:R-HSA-5673001|reactome:R-HSA-5682910|reactome:R-HSA-6794361|reactome:R-HSA-8849932|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-5625900|reactome:R-HSA-9620244|refseq:NP_001308004.1|refseq:NP_001356.1|refseq:NP_001122299.1|dip:DIP-30919N	refseq:NP_001017921.1|ensembl:ENSG00000187650(gene)|ensembl:ENST00000339485(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0045098"(type III intermediate filament)|interpro:IPR038809|mint:Q2NL98	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:VhIVoWngQFYTjco3EzG0If9uh+Y9606	rogid:uE3A2XhetBP92kP4nP8zhjNG0co9606	rigid:ZESRFrRqWOBg0qBrMeWrDY2/DGA	false	sufficient binding region:298-550	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P78352	uniprotkb:Q9BVA1	intact:EBI-80389|ensembl:ENSP00000382425|intact:EBI-1760259|uniprotkb:Q92941|uniprotkb:Q9UKK8|intact:EBI-1965339|uniprotkb:B7Z1S1|uniprotkb:G5E939	intact:EBI-355665|uniprotkb:A8K068|ensembl:ENSP00000259818	psi-mi:dlg4_human(display_long)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)|uniprotkb:DLG4(gene name)|psi-mi:DLG4(display_short)|uniprotkb:PSD95(gene name synonym)	psi-mi:tbb2b_human(display_long)|uniprotkb:TUBB2B(gene name)|psi-mi:TUBB2B(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509418|imex:IM-28561-1745	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000132535(gene)|ensembl:ENST00000399506(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007399"(nervous system development)|go:"GO:0007612"(learning)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019900"(kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:P78352|rcsb pdb:1KEF|rcsb pdb:2MES|rcsb pdb:3I4W|rcsb pdb:3K82|rcsb pdb:3ZRT|rcsb pdb:5J7J|rcsb pdb:5JXB|rcsb pdb:6QJD|rcsb pdb:6QJF|rcsb pdb:6QJG|rcsb pdb:6QJI|rcsb pdb:6QJJ|rcsb pdb:6QJK|rcsb pdb:6QJL|rcsb pdb:6QJN|rcsb pdb:6SPV|rcsb pdb:6SPZ|reactome:R-HSA-1236394|reactome:R-HSA-399719|reactome:R-HSA-438066|reactome:R-HSA-442982|reactome:R-HSA-447038|reactome:R-HSA-451308|reactome:R-HSA-5673001|reactome:R-HSA-5682910|reactome:R-HSA-6794361|reactome:R-HSA-8849932|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-5625900|reactome:R-HSA-9620244|refseq:NP_001308004.1|refseq:NP_001356.1|refseq:NP_001122299.1|dip:DIP-30919N	refseq:NP_821080.1|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0001764"(neuron migration)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0007017"(microtubule-based process)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:1902669"(positive regulation of axon guidance)|go:"GO:1990403"(embryonic brain development)|interpro:IPR000217(Tubulin)|interpro:IPR002453(Beta tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR013838(Beta tubulin, autoregulation binding site)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:Q9BVA1|rcsb pdb:6E7C|reactome:R-HSA-1445148|reactome:R-HSA-190840|reactome:R-HSA-190861|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3371497|reactome:R-HSA-380320|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-389977|reactome:R-HSA-437239|reactome:R-HSA-5610787|reactome:R-HSA-5617833|reactome:R-HSA-5620924|reactome:R-HSA-5626467|ensembl:ENST00000259818(transcript)|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8852276|reactome:R-HSA-8955332|reactome:R-HSA-9609690|reactome:R-HSA-9609736|reactome:R-HSA-9619483|reactome:R-HSA-9646399|reactome:R-HSA-9648025|reactome:R-HSA-9668328|reactome:R-HSA-983189|reactome:R-HSA-5663220|ensembl:ENSG00000137285(gene)	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:VhIVoWngQFYTjco3EzG0If9uh+Y9606	rogid:sluQMryNuOvp6xlV558+agiRwvE9606	rigid:68ADQcLSopK4oLkUROm4M3rCNCI	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P78352	uniprotkb:Q5JTD0	intact:EBI-80389|ensembl:ENSP00000382425|intact:EBI-1760259|uniprotkb:Q92941|uniprotkb:Q9UKK8|intact:EBI-1965339|uniprotkb:B7Z1S1|uniprotkb:G5E939	intact:EBI-2814077|uniprotkb:Q5JTD1|uniprotkb:Q68DB2|uniprotkb:Q5JWW1|uniprotkb:Q6P2P3|uniprotkb:Q9H7V7|uniprotkb:Q05BH9|intact:EBI-28984091|ensembl:ENSP00000361522|ensembl:ENSP00000361527|ensembl:ENSP00000408769	psi-mi:dlg4_human(display_long)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)|uniprotkb:DLG4(gene name)|psi-mi:DLG4(display_short)|uniprotkb:PSD95(gene name synonym)	psi-mi:tjap1_human(display_long)|uniprotkb:TJAP1(gene name)|psi-mi:TJAP1(display_short)|uniprotkb:PILT(gene name synonym)|uniprotkb:TJP4(gene name synonym)|uniprotkb:Protein incorporated later into tight junctions(gene name synonym)|uniprotkb:Tight junction protein 4(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509409|imex:IM-28561-1743	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000132535(gene)|ensembl:ENST00000399506(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007399"(nervous system development)|go:"GO:0007612"(learning)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019900"(kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:P78352|rcsb pdb:1KEF|rcsb pdb:2MES|rcsb pdb:3I4W|rcsb pdb:3K82|rcsb pdb:3ZRT|rcsb pdb:5J7J|rcsb pdb:5JXB|rcsb pdb:6QJD|rcsb pdb:6QJF|rcsb pdb:6QJG|rcsb pdb:6QJI|rcsb pdb:6QJJ|rcsb pdb:6QJK|rcsb pdb:6QJL|rcsb pdb:6QJN|rcsb pdb:6SPV|rcsb pdb:6SPZ|reactome:R-HSA-1236394|reactome:R-HSA-399719|reactome:R-HSA-438066|reactome:R-HSA-442982|reactome:R-HSA-447038|reactome:R-HSA-451308|reactome:R-HSA-5673001|reactome:R-HSA-5682910|reactome:R-HSA-6794361|reactome:R-HSA-8849932|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-5625900|reactome:R-HSA-9620244|refseq:NP_001308004.1|refseq:NP_001356.1|refseq:NP_001122299.1|dip:DIP-30919N	refseq:XP_011513297.1|refseq:NP_001139492.1|refseq:NP_542171.2|refseq:NP_001139488.1|refseq:NP_001139489.1|refseq:NP_001139490.1|refseq:NP_001139491.1|refseq:XP_016866977.1|refseq:XP_016866978.1|refseq:XP_016866981.1|refseq:XP_016866982.1|refseq:XP_006715322.1|refseq:XP_006715323.1|refseq:XP_006715324.1|refseq:XP_006715325.1|refseq:XP_006715326.1|refseq:XP_006715328.1|refseq:XP_006715329.1|ensembl:ENSG00000137221(gene)|ensembl:ENST00000372445(transcript)|ensembl:ENST00000372449(transcript)|ensembl:ENST00000438588(transcript)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007030"(Golgi organization)|interpro:IPR028179|interpro:IPR043441|interpro:IPR043470|mint:Q5JTD0|refseq:XP_006715312.1|refseq:XP_006715313.1|refseq:XP_006715314.1|refseq:XP_006715315.1|refseq:XP_006715317.1|refseq:XP_006715319.1|refseq:XP_006715320.1|ensembl:ENST00000259751|ensembl:ENSP00000259751|ensembl:ENST00000372444|ensembl:ENSP00000361521|ensembl:ENSP00000361522|ensembl:ENSP00000361527|ensembl:ENST00000372452|ensembl:ENSP00000361530|ensembl:ENST00000436109|ensembl:ENSP00000407080|ensembl:ENSP00000408769|ensembl:ENST00000612912|ensembl:ENSP00000484142|refseq:XP_016866979.1|refseq:XP_016866980.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:VhIVoWngQFYTjco3EzG0If9uh+Y9606	rogid:Rn4TPVz2INwUzgJ7MGJ9CKHYaaM9606	rigid:oTILfyMwmFwydNVKRbsaW9DVpAA	false	sufficient binding region:546-724	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P78352	uniprotkb:Q96J01	intact:EBI-80389|ensembl:ENSP00000382425|intact:EBI-1760259|uniprotkb:Q92941|uniprotkb:Q9UKK8|intact:EBI-1965339|uniprotkb:B7Z1S1|uniprotkb:G5E939	intact:EBI-2510823|ensembl:ENSP00000265097|uniprotkb:Q6NZ53	psi-mi:dlg4_human(display_long)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)|uniprotkb:DLG4(gene name)|psi-mi:DLG4(display_short)|uniprotkb:PSD95(gene name synonym)	psi-mi:thoc3_human(display_long)|uniprotkb:THOC3(gene name)|psi-mi:THOC3(display_short)|uniprotkb:TEX1 homolog(gene name synonym)|uniprotkb:hTREX45(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509400|imex:IM-28561-625	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000132535(gene)|ensembl:ENST00000399506(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007399"(nervous system development)|go:"GO:0007612"(learning)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019900"(kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:P78352|rcsb pdb:1KEF|rcsb pdb:2MES|rcsb pdb:3I4W|rcsb pdb:3K82|rcsb pdb:3ZRT|rcsb pdb:5J7J|rcsb pdb:5JXB|rcsb pdb:6QJD|rcsb pdb:6QJF|rcsb pdb:6QJG|rcsb pdb:6QJI|rcsb pdb:6QJJ|rcsb pdb:6QJK|rcsb pdb:6QJL|rcsb pdb:6QJN|rcsb pdb:6SPV|rcsb pdb:6SPZ|reactome:R-HSA-1236394|reactome:R-HSA-399719|reactome:R-HSA-438066|reactome:R-HSA-442982|reactome:R-HSA-447038|reactome:R-HSA-451308|reactome:R-HSA-5673001|reactome:R-HSA-5682910|reactome:R-HSA-6794361|reactome:R-HSA-8849932|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-5625900|reactome:R-HSA-9620244|refseq:NP_001308004.1|refseq:NP_001356.1|refseq:NP_001122299.1|dip:DIP-30919N	ensembl:ENSG00000051596(gene)|ensembl:ENST00000265097(transcript)|go:"GO:0000346"(transcription export complex)|go:"GO:0000445"(THO complex part of transcription export complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0046784"(viral mRNA export from host cell nucleus)|interpro:IPR001680(WD40 repeat)|interpro:IPR013979(Eukaryotic translation initiation factor 2A, central region)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR020472|interpro:IPR024977|interpro:IPR036322|interpro:IPR040132|mint:Q96J01|rcsb pdb:7APK|reactome:R-HSA-159236|reactome:R-HSA-72187|reactome:R-HSA-73856|refseq:NP_115737.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:VhIVoWngQFYTjco3EzG0If9uh+Y9606	rogid:ENG6Gf3Q6WsTn5qkASarueRR+qc9606	rigid:KcAG3O7IGxQaTXxYoKMK9o/i3q8	false	sufficient binding region:298-550	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P78352	uniprotkb:Q96PV0	intact:EBI-80389|ensembl:ENSP00000382425|intact:EBI-1760259|uniprotkb:Q92941|uniprotkb:Q9UKK8|intact:EBI-1965339|uniprotkb:B7Z1S1|uniprotkb:G5E939	intact:EBI-2682386|uniprotkb:Q9UGE2|uniprotkb:A8MQC4|uniprotkb:Q8TCS2|uniprotkb:A2AB17|uniprotkb:A2BEL6|uniprotkb:A2BEL7|intact:EBI-28975552|ensembl:ENSP00000414259|ensembl:ENSP00000486463|ensembl:ENSP00000496007	psi-mi:dlg4_human(display_long)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)|uniprotkb:DLG4(gene name)|psi-mi:DLG4(display_short)|uniprotkb:PSD95(gene name synonym)	psi-mi:sygp1_human(display_long)|uniprotkb:KIAA1938(gene name synonym)|uniprotkb:Neuronal RasGAP(gene name synonym)|uniprotkb:Synaptic Ras GTPase-activating protein 1(gene name synonym)|uniprotkb:SYNGAP1(gene name)|psi-mi:SYNGAP1(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509391|imex:IM-28561-1283	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000132535(gene)|ensembl:ENST00000399506(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007399"(nervous system development)|go:"GO:0007612"(learning)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019900"(kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:P78352|rcsb pdb:1KEF|rcsb pdb:2MES|rcsb pdb:3I4W|rcsb pdb:3K82|rcsb pdb:3ZRT|rcsb pdb:5J7J|rcsb pdb:5JXB|rcsb pdb:6QJD|rcsb pdb:6QJF|rcsb pdb:6QJG|rcsb pdb:6QJI|rcsb pdb:6QJJ|rcsb pdb:6QJK|rcsb pdb:6QJL|rcsb pdb:6QJN|rcsb pdb:6SPV|rcsb pdb:6SPZ|reactome:R-HSA-1236394|reactome:R-HSA-399719|reactome:R-HSA-438066|reactome:R-HSA-442982|reactome:R-HSA-447038|reactome:R-HSA-451308|reactome:R-HSA-5673001|reactome:R-HSA-5682910|reactome:R-HSA-6794361|reactome:R-HSA-8849932|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-5625900|reactome:R-HSA-9620244|refseq:NP_001308004.1|refseq:NP_001356.1|refseq:NP_001122299.1|dip:DIP-30919N	ensembl:ENST00000628646|ensembl:ENSP00000486431|ensembl:ENSP00000486463|ensembl:ENSP00000496007|ensembl:ENST00000395071|ensembl:ENSP00000378509|ensembl:ENST00000414753|ensembl:ENSP00000407995|ensembl:ENST00000418600|ensembl:ENSP00000403636|ensembl:ENST00000428982|ensembl:ENSP00000412475|ensembl:ENSP00000414259|refseq:NP_006763.2|refseq:NP_001123538.1|ensembl:ENSG00000197283(gene)|ensembl:ENSG00000227460(gene)|ensembl:ENST00000455687(transcript)|ensembl:ENST00000629380(transcript)|ensembl:ENST00000646630(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007389"(pattern specification process)|go:"GO:0008542"(visual learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021887|interpro:IPR023152|interpro:IPR035892|interpro:IPR037779|interpro:IPR039360|mint:Q96PV0|reactome:R-HSA-5658442	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:VhIVoWngQFYTjco3EzG0If9uh+Y9606	rogid:3Uq2PiuV/QQyjjPbPJS+CgN8+W89606	rigid:JsqVygydx6cPwkqrnByCfppQANk	false	sufficient binding region:298-550	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P78352	uniprotkb:O43166	intact:EBI-80389|ensembl:ENSP00000382425|intact:EBI-1760259|uniprotkb:Q92941|uniprotkb:Q9UKK8|intact:EBI-1965339|uniprotkb:B7Z1S1|uniprotkb:G5E939	intact:EBI-310678|uniprotkb:O95321|uniprotkb:Q9UDU4|uniprotkb:Q9UNU4|intact:EBI-11025469|intact:EBI-28973250|uniprotkb:J3KP19|ensembl:ENSP00000450832	psi-mi:dlg4_human(display_long)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)|uniprotkb:DLG4(gene name)|psi-mi:DLG4(display_short)|uniprotkb:PSD95(gene name synonym)	psi-mi:si1l1_human(display_long)|uniprotkb:SIPA1L1(gene name)|psi-mi:SIPA1L1(display_short)|uniprotkb:E6TP1(gene name synonym)|uniprotkb:KIAA0440(gene name synonym)|uniprotkb:High-risk human papilloma viruses E6 oncoproteins targeted protein 1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509382|imex:IM-28561-623	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000132535(gene)|ensembl:ENST00000399506(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007399"(nervous system development)|go:"GO:0007612"(learning)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019900"(kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:P78352|rcsb pdb:1KEF|rcsb pdb:2MES|rcsb pdb:3I4W|rcsb pdb:3K82|rcsb pdb:3ZRT|rcsb pdb:5J7J|rcsb pdb:5JXB|rcsb pdb:6QJD|rcsb pdb:6QJF|rcsb pdb:6QJG|rcsb pdb:6QJI|rcsb pdb:6QJJ|rcsb pdb:6QJK|rcsb pdb:6QJL|rcsb pdb:6QJN|rcsb pdb:6SPV|rcsb pdb:6SPZ|reactome:R-HSA-1236394|reactome:R-HSA-399719|reactome:R-HSA-438066|reactome:R-HSA-442982|reactome:R-HSA-447038|reactome:R-HSA-451308|reactome:R-HSA-5673001|reactome:R-HSA-5682910|reactome:R-HSA-6794361|reactome:R-HSA-8849932|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-5625900|reactome:R-HSA-9620244|refseq:NP_001308004.1|refseq:NP_001356.1|refseq:NP_001122299.1|dip:DIP-30919N	ensembl:ENST00000358550|ensembl:ENSP00000351352|ensembl:ENST00000381232|ensembl:ENSP00000370630|ensembl:ENSP00000450832|refseq:NP_001271174.1|refseq:NP_001271175.1|refseq:NP_056371.1|refseq:XP_005267573.1|refseq:XP_011534932.1|refseq:XP_011534933.1|refseq:XP_011534934.1|refseq:XP_011534937.1|refseq:XP_016876648.1|refseq:XP_016876649.1|refseq:XP_016876650.1|refseq:XP_016876651.1|refseq:XP_016876652.1|refseq:XP_016876653.1|refseq:XP_016876654.1|refseq:XP_016876655.1|refseq:XP_016876656.1|refseq:XP_016876657.1|refseq:XP_016876658.1|refseq:XP_016876659.1|refseq:XP_016876660.1|refseq:XP_016876661.1|refseq:XP_016876662.1|refseq:XP_016876663.1|refseq:XP_016876664.1|refseq:XP_016876665.1|refseq:XP_016876666.1|refseq:XP_016876667.1|refseq:XP_016876668.1|refseq:XP_016876669.1|refseq:XP_016876675.1|refseq:XP_016876676.1|refseq:XP_016876677.1|refseq:XP_016876678.1|refseq:XP_016876679.1|refseq:XP_016876680.1|refseq:XP_016876681.1|refseq:XP_016876682.1|ensembl:ENSG00000197555(gene)|ensembl:ENST00000555818(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR000331(Rap/ran-GAP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR021818|interpro:IPR030770|interpro:IPR035974|interpro:IPR036034|mint:O43166|reactome:R-HSA-6794361	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:VhIVoWngQFYTjco3EzG0If9uh+Y9606	rogid:whpEjAhxfeYqeZ1IbjNl6romgXk9606	rigid:fRoFrdyYuZ4WsXAw2ghtvuC/oTQ	false	sufficient binding region:298-550,546-724	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9H2L5	uniprotkb:P78352	intact:EBI-2933362|ensembl:ENSP00000339692|uniprotkb:Q86WH5|uniprotkb:Q86WH6|uniprotkb:Q86WH7|uniprotkb:Q8N5A9|uniprotkb:Q8TCK6	intact:EBI-80389|ensembl:ENSP00000382425|intact:EBI-1760259|uniprotkb:Q92941|uniprotkb:Q9UKK8|intact:EBI-1965339|uniprotkb:B7Z1S1|uniprotkb:G5E939	psi-mi:rasf4_human(display_long)|uniprotkb:RASSF4(gene name)|psi-mi:RASSF4(display_short)|uniprotkb:AD037(orf name)	psi-mi:dlg4_human(display_long)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)|uniprotkb:DLG4(gene name)|psi-mi:DLG4(display_short)|uniprotkb:PSD95(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509373|imex:IM-28561-621	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000107551(gene)|ensembl:ENST00000340258(transcript)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|interpro:IPR000159(Ras-association)|interpro:IPR011524(SARAH)|interpro:IPR029071|interpro:IPR033614|interpro:IPR033622|mint:Q9H2L5|refseq:NP_114412.2	ensembl:ENSG00000132535(gene)|ensembl:ENST00000399506(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007399"(nervous system development)|go:"GO:0007612"(learning)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019900"(kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:P78352|rcsb pdb:1KEF|rcsb pdb:2MES|rcsb pdb:3I4W|rcsb pdb:3K82|rcsb pdb:3ZRT|rcsb pdb:5J7J|rcsb pdb:5JXB|rcsb pdb:6QJD|rcsb pdb:6QJF|rcsb pdb:6QJG|rcsb pdb:6QJI|rcsb pdb:6QJJ|rcsb pdb:6QJK|rcsb pdb:6QJL|rcsb pdb:6QJN|rcsb pdb:6SPV|rcsb pdb:6SPZ|reactome:R-HSA-1236394|reactome:R-HSA-399719|reactome:R-HSA-438066|reactome:R-HSA-442982|reactome:R-HSA-447038|reactome:R-HSA-451308|reactome:R-HSA-5673001|reactome:R-HSA-5682910|reactome:R-HSA-6794361|reactome:R-HSA-8849932|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-5625900|reactome:R-HSA-9620244|refseq:NP_001308004.1|refseq:NP_001356.1|refseq:NP_001122299.1|dip:DIP-30919N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:sCKT+Fathr9arh0tfTQjXqq+ZAM9606	rogid:VhIVoWngQFYTjco3EzG0If9uh+Y9606	rigid:hy+j87I5w3N9ujK8HhCCKFudiMc	false	-	sufficient binding region:546-724	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P78352	uniprotkb:Q15311	intact:EBI-80389|ensembl:ENSP00000382425|intact:EBI-1760259|uniprotkb:Q92941|uniprotkb:Q9UKK8|intact:EBI-1965339|uniprotkb:B7Z1S1|uniprotkb:G5E939	intact:EBI-749285|uniprotkb:D3DUI0|ensembl:ENSP00000019317|ensembl:ENSP00000372924	psi-mi:dlg4_human(display_long)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)|uniprotkb:DLG4(gene name)|psi-mi:DLG4(display_short)|uniprotkb:PSD95(gene name synonym)	psi-mi:rbp1_human(display_long)|uniprotkb:Ral-interacting protein 1(gene name synonym)|uniprotkb:76 kDa Ral-interacting protein(gene name synonym)|uniprotkb:Dinitrophenyl S-glutathione ATPase(gene name synonym)|uniprotkb:RALBP1(gene name)|psi-mi:RALBP1(display_short)|uniprotkb:RLIP1(gene name synonym)|uniprotkb:RLIP76(gene name synonym)|uniprotkb:RLIP(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509364|imex:IM-28561-1281	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000132535(gene)|ensembl:ENST00000399506(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007399"(nervous system development)|go:"GO:0007612"(learning)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019900"(kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:P78352|rcsb pdb:1KEF|rcsb pdb:2MES|rcsb pdb:3I4W|rcsb pdb:3K82|rcsb pdb:3ZRT|rcsb pdb:5J7J|rcsb pdb:5JXB|rcsb pdb:6QJD|rcsb pdb:6QJF|rcsb pdb:6QJG|rcsb pdb:6QJI|rcsb pdb:6QJJ|rcsb pdb:6QJK|rcsb pdb:6QJL|rcsb pdb:6QJN|rcsb pdb:6SPV|rcsb pdb:6SPZ|reactome:R-HSA-1236394|reactome:R-HSA-399719|reactome:R-HSA-438066|reactome:R-HSA-442982|reactome:R-HSA-447038|reactome:R-HSA-451308|reactome:R-HSA-5673001|reactome:R-HSA-5682910|reactome:R-HSA-6794361|reactome:R-HSA-8849932|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-5625900|reactome:R-HSA-9620244|refseq:NP_001308004.1|refseq:NP_001356.1|refseq:NP_001122299.1|dip:DIP-30919N	refseq:NP_006779.1|ensembl:ENSG00000017797(gene)|ensembl:ENST00000019317(transcript)|ensembl:ENST00000383432(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008559"(ABC-type xenobiotic transporter activity)|go:"GO:0015431"(ABC-type glutathione S-conjugate transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032489"(regulation of Cdc42 protein signal transduction)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0042910"(xenobiotic transmembrane transporter activity)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0055085"(transmembrane transport)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:1900753"(doxorubicin transport)|go:"GO:1990961"(xenobiotic detoxification by transmembrane export across the plasma membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR039767|mint:Q15311|rcsb pdb:2KWH|rcsb pdb:2KWI|rcsb pdb:2MBG|rcsb pdb:6ZQT|rcsb pdb:6ZRN|reactome:R-HSA-9013148|reactome:R-HSA-9013149	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:VhIVoWngQFYTjco3EzG0If9uh+Y9606	rogid:6u1yy+UdGWJbJ9SiItSAp+CqeVk9606	rigid:g1QzbB7pHFQMQIxiEgWIlZsB1tI	false	sufficient binding region:298-550	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P78352	uniprotkb:Q569H4	intact:EBI-80389|ensembl:ENSP00000382425|intact:EBI-1760259|uniprotkb:Q92941|uniprotkb:Q9UKK8|intact:EBI-1965339|uniprotkb:B7Z1S1|uniprotkb:G5E939	intact:EBI-5564642|uniprotkb:D3DSZ0|uniprotkb:Q8IXY1|uniprotkb:Q9NYI5|ensembl:ENSP00000385118	psi-mi:dlg4_human(display_long)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)|uniprotkb:DLG4(gene name)|psi-mi:DLG4(display_short)|uniprotkb:PSD95(gene name synonym)	psi-mi:largn_human(display_long)|uniprotkb:PRR16(gene name)|psi-mi:PRR16(display_short)|uniprotkb:Mesenchymal stem cell protein DSC54(gene name synonym)|uniprotkb:Proline-rich protein 16(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509357|imex:IM-28561-1741	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000132535(gene)|ensembl:ENST00000399506(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007399"(nervous system development)|go:"GO:0007612"(learning)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019900"(kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:P78352|rcsb pdb:1KEF|rcsb pdb:2MES|rcsb pdb:3I4W|rcsb pdb:3K82|rcsb pdb:3ZRT|rcsb pdb:5J7J|rcsb pdb:5JXB|rcsb pdb:6QJD|rcsb pdb:6QJF|rcsb pdb:6QJG|rcsb pdb:6QJI|rcsb pdb:6QJJ|rcsb pdb:6QJK|rcsb pdb:6QJL|rcsb pdb:6QJN|rcsb pdb:6SPV|rcsb pdb:6SPZ|reactome:R-HSA-1236394|reactome:R-HSA-399719|reactome:R-HSA-438066|reactome:R-HSA-442982|reactome:R-HSA-447038|reactome:R-HSA-451308|reactome:R-HSA-5673001|reactome:R-HSA-5682910|reactome:R-HSA-6794361|reactome:R-HSA-8849932|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-5625900|reactome:R-HSA-9620244|refseq:NP_001308004.1|refseq:NP_001356.1|refseq:NP_001122299.1|dip:DIP-30919N	refseq:NP_001287712.1|refseq:NP_001295016.1|refseq:NP_001295017.1|refseq:XP_011541756.1|refseq:NP_057728.1|ensembl:ENSG00000184838(gene)|ensembl:ENST00000407149(transcript)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045793"(positive regulation of cell size)|interpro:IPR027997|mint:Q569H4	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:VhIVoWngQFYTjco3EzG0If9uh+Y9606	rogid:9k4tsF8JpSh7aJE6iIwIPFd4xoE9606	rigid:i3zAQYIb6IYUQ1qjSGFPyS0nmyk	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P78352	uniprotkb:Q9NRD5	intact:EBI-80389|ensembl:ENSP00000382425|intact:EBI-1760259|uniprotkb:Q92941|uniprotkb:Q9UKK8|intact:EBI-1965339|uniprotkb:B7Z1S1|uniprotkb:G5E939	intact:EBI-79165|uniprotkb:O95906|ensembl:ENSP00000349465|ensembl:ENSP00000385205|intact:EBI-2622151|uniprotkb:B3KS52	psi-mi:dlg4_human(display_long)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)|uniprotkb:DLG4(gene name)|psi-mi:DLG4(display_short)|uniprotkb:PSD95(gene name synonym)	psi-mi:pick1_human(display_long)|uniprotkb:PICK1(gene name)|psi-mi:PICK1(display_short)|uniprotkb:PRKCABP(gene name synonym)|uniprotkb:Protein kinase C-alpha-binding protein(gene name synonym)|uniprotkb:Protein interacting with C kinase 1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509348|imex:IM-28561-145	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000132535(gene)|ensembl:ENST00000399506(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007399"(nervous system development)|go:"GO:0007612"(learning)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019900"(kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:P78352|rcsb pdb:1KEF|rcsb pdb:2MES|rcsb pdb:3I4W|rcsb pdb:3K82|rcsb pdb:3ZRT|rcsb pdb:5J7J|rcsb pdb:5JXB|rcsb pdb:6QJD|rcsb pdb:6QJF|rcsb pdb:6QJG|rcsb pdb:6QJI|rcsb pdb:6QJJ|rcsb pdb:6QJK|rcsb pdb:6QJL|rcsb pdb:6QJN|rcsb pdb:6SPV|rcsb pdb:6SPZ|reactome:R-HSA-1236394|reactome:R-HSA-399719|reactome:R-HSA-438066|reactome:R-HSA-442982|reactome:R-HSA-447038|reactome:R-HSA-451308|reactome:R-HSA-5673001|reactome:R-HSA-5682910|reactome:R-HSA-6794361|reactome:R-HSA-8849932|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-5625900|reactome:R-HSA-9620244|refseq:NP_001308004.1|refseq:NP_001356.1|refseq:NP_001122299.1|dip:DIP-30919N	ensembl:ENSG00000100151(gene)|ensembl:ENST00000356976(transcript)|ensembl:ENST00000404072(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|refseq:NP_001034672.1|refseq:NP_001034673.1|refseq:NP_036539.1|go:"GO:0015844"(monoamine transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021782"(glial cell development)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0034315"(regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0034316"(negative regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0036294"(cellular response to decreased oxygen levels)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0043113"(receptor clustering)|go:"GO:0045161"(neuronal ion channel clustering)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051015"(actin filament binding)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0098842"(postsynaptic early endosome)|go:"GO:0140090"(membrane curvature sensor activity)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR010504(Arfaptin-like)|interpro:IPR027267|interpro:IPR030798|interpro:IPR036034|interpro:IPR037959|mint:Q9NRD5|rcsb pdb:2GZV|rcsb pdb:6AR4|rcsb pdb:6BJN|rcsb pdb:6BJO|reactome:R-HSA-202733|reactome:R-HSA-416993	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:VhIVoWngQFYTjco3EzG0If9uh+Y9606	rogid:qRx+eNG7We8Oe0SQOekqpJpn8zk9606	rigid:gB4TaGkyiCp/MrEbT+H4WoNt50c	false	sufficient binding region:546-724	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P78352	uniprotkb:P40855	intact:EBI-80389|ensembl:ENSP00000382425|intact:EBI-1760259|uniprotkb:Q92941|uniprotkb:Q9UKK8|intact:EBI-1965339|uniprotkb:B7Z1S1|uniprotkb:G5E939	intact:EBI-594747|uniprotkb:Q8NI97|intact:EBI-981972|uniprotkb:Q5QNY4|uniprotkb:D3DVE7|ensembl:ENSP00000357051	psi-mi:dlg4_human(display_long)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)|uniprotkb:DLG4(gene name)|psi-mi:DLG4(display_short)|uniprotkb:PSD95(gene name synonym)	psi-mi:pex19_human(display_long)|uniprotkb:PEX19(gene name)|psi-mi:PEX19(display_short)|uniprotkb:HK33(gene name synonym)|uniprotkb:PXF(gene name synonym)|uniprotkb:OK/SW-cl.22(orf name)|uniprotkb:Peroxin-19(gene name synonym)|uniprotkb:Peroxisomal farnesylated protein(gene name synonym)|uniprotkb:33 kDa housekeeping protein(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509339|imex:IM-28561-143	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000132535(gene)|ensembl:ENST00000399506(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007399"(nervous system development)|go:"GO:0007612"(learning)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019900"(kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:P78352|rcsb pdb:1KEF|rcsb pdb:2MES|rcsb pdb:3I4W|rcsb pdb:3K82|rcsb pdb:3ZRT|rcsb pdb:5J7J|rcsb pdb:5JXB|rcsb pdb:6QJD|rcsb pdb:6QJF|rcsb pdb:6QJG|rcsb pdb:6QJI|rcsb pdb:6QJJ|rcsb pdb:6QJK|rcsb pdb:6QJL|rcsb pdb:6QJN|rcsb pdb:6SPV|rcsb pdb:6SPZ|reactome:R-HSA-1236394|reactome:R-HSA-399719|reactome:R-HSA-438066|reactome:R-HSA-442982|reactome:R-HSA-447038|reactome:R-HSA-451308|reactome:R-HSA-5673001|reactome:R-HSA-5682910|reactome:R-HSA-6794361|reactome:R-HSA-8849932|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-5625900|reactome:R-HSA-9620244|refseq:NP_001308004.1|refseq:NP_001356.1|refseq:NP_001122299.1|dip:DIP-30919N	refseq:NP_001180573.1|refseq:NP_002848.1|dip:DIP-24172N|ensembl:ENSG00000162735(gene)|ensembl:ENST00000368072(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005777"(peroxisome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006625"(protein targeting to peroxisome)|go:"GO:0007031"(peroxisome organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016557"(peroxisome membrane biogenesis)|go:"GO:0016559"(peroxisome fission)|go:"GO:0031526"(brush border membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033328"(peroxisome membrane targeting sequence binding)|go:"GO:0036105"(peroxisome membrane class-1 targeting sequence binding)|go:"GO:0045046"(protein import into peroxisome membrane)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0072663"(establishment of protein localization to peroxisome)|go:"GO:0140597"(protein carrier chaperone)|go:"GO:1900131"(negative regulation of lipid binding)|interpro:IPR006708(Pex19 protein)|interpro:IPR038322|mint:P40855|rcsb pdb:2W85|rcsb pdb:2WL8|rcsb pdb:3AJB|rcsb pdb:3MK4|rcsb pdb:5LNF|reactome:R-HSA-1369062|reactome:R-HSA-9603798	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:VhIVoWngQFYTjco3EzG0If9uh+Y9606	rogid:yNnX2hPPJ7miGaz2Req0qFn0L189606	rigid:0kmMptqrHvJDS4ay+KU1DhMWPGs	false	sufficient binding region:546-724	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P78352	uniprotkb:P22061	intact:EBI-80389|ensembl:ENSP00000382425|intact:EBI-1760259|uniprotkb:Q92941|uniprotkb:Q9UKK8|intact:EBI-1965339|uniprotkb:B7Z1S1|uniprotkb:G5E939	intact:EBI-353343|uniprotkb:Q14661|uniprotkb:Q16556|uniprotkb:Q5VYC1|uniprotkb:Q5VYC2|uniprotkb:Q93061|uniprotkb:Q96II9|uniprotkb:Q99625|uniprotkb:Q9BQV7|uniprotkb:Q9BQV8|uniprotkb:Q9NP03|uniprotkb:A8K109|intact:EBI-2551555|uniprotkb:J3KP72|ensembl:ENSP00000356348|ensembl:ENSP00000420813	psi-mi:dlg4_human(display_long)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)|uniprotkb:DLG4(gene name)|psi-mi:DLG4(display_short)|uniprotkb:PSD95(gene name synonym)	psi-mi:pimt_human(display_long)|uniprotkb:PCMT1(gene name)|psi-mi:PCMT1(display_short)|uniprotkb:Protein-beta-aspartate methyltransferase(gene name synonym)|uniprotkb:Protein L-isoaspartyl/D-aspartyl methyltransferase(gene name synonym)|uniprotkb:L-isoaspartyl protein carboxyl methyltransferase(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509330|imex:IM-28561-1221	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000132535(gene)|ensembl:ENST00000399506(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007399"(nervous system development)|go:"GO:0007612"(learning)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019900"(kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:P78352|rcsb pdb:1KEF|rcsb pdb:2MES|rcsb pdb:3I4W|rcsb pdb:3K82|rcsb pdb:3ZRT|rcsb pdb:5J7J|rcsb pdb:5JXB|rcsb pdb:6QJD|rcsb pdb:6QJF|rcsb pdb:6QJG|rcsb pdb:6QJI|rcsb pdb:6QJJ|rcsb pdb:6QJK|rcsb pdb:6QJL|rcsb pdb:6QJN|rcsb pdb:6SPV|rcsb pdb:6SPZ|reactome:R-HSA-1236394|reactome:R-HSA-399719|reactome:R-HSA-438066|reactome:R-HSA-442982|reactome:R-HSA-447038|reactome:R-HSA-451308|reactome:R-HSA-5673001|reactome:R-HSA-5682910|reactome:R-HSA-6794361|reactome:R-HSA-8849932|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-5625900|reactome:R-HSA-9620244|refseq:NP_001308004.1|refseq:NP_001356.1|refseq:NP_001122299.1|dip:DIP-30919N	refseq:NP_001238978.1|refseq:NP_001238982.1|ensembl:ENSG00000120265(gene)|ensembl:ENST00000367378(transcript)|ensembl:ENST00000464889(transcript)|go:"GO:0004719"("protein-L-isoaspartate (D-aspartate) O-methyltransferase activity")|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006479"(protein methylation)|go:"GO:0030091"(protein repair)|go:"GO:0045296"(cadherin binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903561"(extracellular vesicle)|interpro:IPR000682("Protein-L-isoaspartate(D-aspartate) O-methyltransferase")|interpro:IPR029063|mint:P22061|rcsb pdb:1I1N|rcsb pdb:1KR5|reactome:R-HSA-5676934|refseq:NP_005380.2	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:VhIVoWngQFYTjco3EzG0If9uh+Y9606	rogid:wfsjVloc3sqDMXlvFAXQI6Fjilw9606	rigid:aS2puS00SGRf7+V+5LsKn/HIQy0	false	sufficient binding region:298-550	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P78352	uniprotkb:Q15155	intact:EBI-80389|ensembl:ENSP00000382425|intact:EBI-1760259|uniprotkb:Q92941|uniprotkb:Q9UKK8|intact:EBI-1965339|uniprotkb:B7Z1S1|uniprotkb:G5E939	intact:EBI-373107|uniprotkb:P78421|uniprotkb:Q8IW21|uniprotkb:Q96DG0|ensembl:ENSP00000287667|ensembl:ENSP00000482008	psi-mi:dlg4_human(display_long)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)|uniprotkb:DLG4(gene name)|psi-mi:DLG4(display_short)|uniprotkb:PSD95(gene name synonym)	psi-mi:nomo1_human(display_long)|uniprotkb:PM5(gene name synonym)|uniprotkb:NOMO1(gene name)|psi-mi:NOMO1(display_short)|uniprotkb:pM5 protein(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509321|imex:IM-28561-1703	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000132535(gene)|ensembl:ENST00000399506(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007399"(nervous system development)|go:"GO:0007612"(learning)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019900"(kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:P78352|rcsb pdb:1KEF|rcsb pdb:2MES|rcsb pdb:3I4W|rcsb pdb:3K82|rcsb pdb:3ZRT|rcsb pdb:5J7J|rcsb pdb:5JXB|rcsb pdb:6QJD|rcsb pdb:6QJF|rcsb pdb:6QJG|rcsb pdb:6QJI|rcsb pdb:6QJJ|rcsb pdb:6QJK|rcsb pdb:6QJL|rcsb pdb:6QJN|rcsb pdb:6SPV|rcsb pdb:6SPZ|reactome:R-HSA-1236394|reactome:R-HSA-399719|reactome:R-HSA-438066|reactome:R-HSA-442982|reactome:R-HSA-447038|reactome:R-HSA-451308|reactome:R-HSA-5673001|reactome:R-HSA-5682910|reactome:R-HSA-6794361|reactome:R-HSA-8849932|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-5625900|reactome:R-HSA-9620244|refseq:NP_001308004.1|refseq:NP_001356.1|refseq:NP_001122299.1|dip:DIP-30919N	refseq:NP_055102.3|interpro:IPR013783(Immunoglobulin-like fold)|ensembl:ENSG00000103512(gene)|ensembl:ENSG00000274779(gene)|ensembl:ENST00000287667(transcript)|ensembl:ENST00000619292(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0043022"(ribosome binding)|interpro:IPR008969(Carboxypeptidase-like, regulatory region)|interpro:IPR013784(Carbohydrate-binding-like fold)|interpro:IPR041033|mint:Q15155	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:VhIVoWngQFYTjco3EzG0If9uh+Y9606	rogid:Dvi85VHhwmSC8qfJp1ufqUqPLdE9606	rigid:nGO0PJNkXn8E9DW/xOm5H5TBDAE	false	sufficient binding region:546-724	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P26358	uniprotkb:O75382	intact:EBI-719459|uniprotkb:Q9UHG5|uniprotkb:Q9ULA2|uniprotkb:Q9UMZ6|uniprotkb:A0AV63|intact:EBI-28971395|ensembl:ENSP00000345739|uniprotkb:B7ZLW6	intact:EBI-2129889|uniprotkb:Q4V9L4|uniprotkb:Q9C038|uniprotkb:Q9C039|uniprotkb:B7Z5E6|uniprotkb:F5H2Q8|ensembl:ENSP00000340797|ensembl:ENSP00000352508|ensembl:ENSP00000433102	psi-mi:dnmt1_human(display_long)|uniprotkb:CXXC9(gene name synonym)|uniprotkb:MCMT(gene name synonym)|uniprotkb:DNA methyltransferase HsaI(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 9(gene name synonym)|uniprotkb:DNMT1(gene name)|psi-mi:DNMT1(display_short)|uniprotkb:AIM(gene name synonym)|uniprotkb:DNMT(gene name synonym)	psi-mi:trim3_human(display_long)|uniprotkb:TRIM3(gene name)|psi-mi:TRIM3(display_short)|uniprotkb:BERP(gene name synonym)|uniprotkb:RNF22(gene name synonym)|uniprotkb:RNF97(gene name synonym)|uniprotkb:RING finger protein 22(gene name synonym)|uniprotkb:Brain-expressed RING finger protein(gene name synonym)|uniprotkb:RING finger protein 97(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509506|imex:IM-28561-189	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000345739|ensembl:ENST00000359526|ensembl:ENSP00000352516|refseq:NP_001124295.1|refseq:NP_001370.1|ensembl:ENSG00000130816(gene)|ensembl:ENST00000340748(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003886"("DNA (cytosine-5-)-methyltransferase activity")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0006306"(DNA methylation)|go:"GO:0006325"(chromatin organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008270"(zinc ion binding)|reactome:R-HSA-427413|reactome:R-HSA-4655427|reactome:R-HSA-5334118|reactome:R-HSA-9710421|refseq:NP_001305659.1|refseq:NP_001305660.1|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0009008"(DNA-methyltransferase activity)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016458"(obsolete gene silencing)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051573"(negative regulation of histone H3-K9 methylation)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0090309"(positive regulation of DNA methylation-dependent heterochromatin assembly)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905460"(negative regulation of vascular associated smooth muscle cell apoptotic process)|go:"GO:1905931"(negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR001525(C-5 cytosine-specific DNA methylase)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR010506(DMAP1-binding)|interpro:IPR017198("DNA (cytosine-5)-methyltransferase 1")|interpro:IPR018117|interpro:IPR022702|interpro:IPR029063|interpro:IPR031303|interpro:IPR043151|mint:P26358|rcsb pdb:3EPZ|rcsb pdb:3PTA|rcsb pdb:3SWR|rcsb pdb:4WXX|rcsb pdb:4YOC|rcsb pdb:4Z96|rcsb pdb:4Z97|rcsb pdb:5WVO|rcsb pdb:5YDR|rcsb pdb:6K3A|reactome:R-HSA-212300|dip:DIP-39693N	refseq:XP_011518146.1|refseq:XP_011518147.1|refseq:NP_006449.2|refseq:NP_150594.2|refseq:XP_016872587.1|refseq:XP_016872588.1|refseq:NP_001234935.1|refseq:NP_001234936.1|ensembl:ENSG00000110171(gene)|ensembl:ENST00000345851(transcript)|ensembl:ENST00000359518(transcript)|ensembl:ENST00000525074(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0007399"(nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015031"(protein transport)|go:"GO:0030425"(dendrite)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001258(NHL repeat)|interpro:IPR001298(Filamin/ABP280 repeat)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003649(B-box, C-terminal)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR013017(NHL repeat, subgroup)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR017907|interpro:IPR027370|mint:O75382|reactome:R-HSA-877300	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:qae3zQwGP5R/+WCWoeahDKZ/9Jg9606	rogid:Vz2XqDSJXAWxxubxtghV91m9K009606	rigid:Hp8jmInnJab/7FYtr0WhLAbU6zU	false	sufficient binding region:245-446	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P26358	uniprotkb:Q9NRD5	intact:EBI-719459|uniprotkb:Q9UHG5|uniprotkb:Q9ULA2|uniprotkb:Q9UMZ6|uniprotkb:A0AV63|intact:EBI-28971395|ensembl:ENSP00000345739|uniprotkb:B7ZLW6	intact:EBI-79165|uniprotkb:O95906|ensembl:ENSP00000349465|ensembl:ENSP00000385205|intact:EBI-2622151|uniprotkb:B3KS52	psi-mi:dnmt1_human(display_long)|uniprotkb:CXXC9(gene name synonym)|uniprotkb:MCMT(gene name synonym)|uniprotkb:DNA methyltransferase HsaI(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 9(gene name synonym)|uniprotkb:DNMT1(gene name)|psi-mi:DNMT1(display_short)|uniprotkb:AIM(gene name synonym)|uniprotkb:DNMT(gene name synonym)	psi-mi:pick1_human(display_long)|uniprotkb:PICK1(gene name)|psi-mi:PICK1(display_short)|uniprotkb:PRKCABP(gene name synonym)|uniprotkb:Protein kinase C-alpha-binding protein(gene name synonym)|uniprotkb:Protein interacting with C kinase 1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509497|imex:IM-28561-1301	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000345739|ensembl:ENST00000359526|ensembl:ENSP00000352516|refseq:NP_001124295.1|refseq:NP_001370.1|ensembl:ENSG00000130816(gene)|ensembl:ENST00000340748(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003886"("DNA (cytosine-5-)-methyltransferase activity")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0006306"(DNA methylation)|go:"GO:0006325"(chromatin organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008270"(zinc ion binding)|reactome:R-HSA-427413|reactome:R-HSA-4655427|reactome:R-HSA-5334118|reactome:R-HSA-9710421|refseq:NP_001305659.1|refseq:NP_001305660.1|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0009008"(DNA-methyltransferase activity)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016458"(obsolete gene silencing)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051573"(negative regulation of histone H3-K9 methylation)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0090309"(positive regulation of DNA methylation-dependent heterochromatin assembly)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905460"(negative regulation of vascular associated smooth muscle cell apoptotic process)|go:"GO:1905931"(negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR001525(C-5 cytosine-specific DNA methylase)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR010506(DMAP1-binding)|interpro:IPR017198("DNA (cytosine-5)-methyltransferase 1")|interpro:IPR018117|interpro:IPR022702|interpro:IPR029063|interpro:IPR031303|interpro:IPR043151|mint:P26358|rcsb pdb:3EPZ|rcsb pdb:3PTA|rcsb pdb:3SWR|rcsb pdb:4WXX|rcsb pdb:4YOC|rcsb pdb:4Z96|rcsb pdb:4Z97|rcsb pdb:5WVO|rcsb pdb:5YDR|rcsb pdb:6K3A|reactome:R-HSA-212300|dip:DIP-39693N	ensembl:ENSG00000100151(gene)|ensembl:ENST00000356976(transcript)|ensembl:ENST00000404072(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|refseq:NP_001034672.1|refseq:NP_001034673.1|refseq:NP_036539.1|go:"GO:0015844"(monoamine transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021782"(glial cell development)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0034315"(regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0034316"(negative regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0036294"(cellular response to decreased oxygen levels)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0043113"(receptor clustering)|go:"GO:0045161"(neuronal ion channel clustering)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051015"(actin filament binding)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0098842"(postsynaptic early endosome)|go:"GO:0140090"(membrane curvature sensor activity)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR010504(Arfaptin-like)|interpro:IPR027267|interpro:IPR030798|interpro:IPR036034|interpro:IPR037959|mint:Q9NRD5|rcsb pdb:2GZV|rcsb pdb:6AR4|rcsb pdb:6BJN|rcsb pdb:6BJO|reactome:R-HSA-202733|reactome:R-HSA-416993	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:qae3zQwGP5R/+WCWoeahDKZ/9Jg9606	rogid:qRx+eNG7We8Oe0SQOekqpJpn8zk9606	rigid:UX2DJuo/tEsU/irEdu1MFHi98FM	false	sufficient binding region:245-446	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P26358	uniprotkb:Q9NPE2	intact:EBI-719459|uniprotkb:Q9UHG5|uniprotkb:Q9ULA2|uniprotkb:Q9UMZ6|uniprotkb:A0AV63|intact:EBI-28971395|ensembl:ENSP00000345739|uniprotkb:B7ZLW6	intact:EBI-2683432|uniprotkb:Q4V9L7|uniprotkb:Q9HBL4|uniprotkb:B2R6M8|ensembl:ENSP00000368389	psi-mi:dnmt1_human(display_long)|uniprotkb:CXXC9(gene name synonym)|uniprotkb:MCMT(gene name synonym)|uniprotkb:DNA methyltransferase HsaI(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 9(gene name synonym)|uniprotkb:DNMT1(gene name)|psi-mi:DNMT1(display_short)|uniprotkb:AIM(gene name synonym)|uniprotkb:DNMT(gene name synonym)	psi-mi:ngrn_human(display_long)|uniprotkb:FI58G(gene name synonym)|uniprotkb:Mesenchymal stem cell protein DSC92(gene name synonym)|uniprotkb:Neurite outgrowth-associated protein(gene name synonym)|uniprotkb:Spinal cord-derived protein FI58G(gene name synonym)|uniprotkb:HT020(orf name)|uniprotkb:NGRN(gene name)|psi-mi:NGRN(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509470|imex:IM-28561-1765	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000345739|ensembl:ENST00000359526|ensembl:ENSP00000352516|refseq:NP_001124295.1|refseq:NP_001370.1|ensembl:ENSG00000130816(gene)|ensembl:ENST00000340748(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003886"("DNA (cytosine-5-)-methyltransferase activity")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0006306"(DNA methylation)|go:"GO:0006325"(chromatin organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008270"(zinc ion binding)|reactome:R-HSA-427413|reactome:R-HSA-4655427|reactome:R-HSA-5334118|reactome:R-HSA-9710421|refseq:NP_001305659.1|refseq:NP_001305660.1|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0009008"(DNA-methyltransferase activity)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016458"(obsolete gene silencing)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051573"(negative regulation of histone H3-K9 methylation)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0090309"(positive regulation of DNA methylation-dependent heterochromatin assembly)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905460"(negative regulation of vascular associated smooth muscle cell apoptotic process)|go:"GO:1905931"(negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR001525(C-5 cytosine-specific DNA methylase)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR010506(DMAP1-binding)|interpro:IPR017198("DNA (cytosine-5)-methyltransferase 1")|interpro:IPR018117|interpro:IPR022702|interpro:IPR029063|interpro:IPR031303|interpro:IPR043151|mint:P26358|rcsb pdb:3EPZ|rcsb pdb:3PTA|rcsb pdb:3SWR|rcsb pdb:4WXX|rcsb pdb:4YOC|rcsb pdb:4Z96|rcsb pdb:4Z97|rcsb pdb:5WVO|rcsb pdb:5YDR|rcsb pdb:6K3A|reactome:R-HSA-212300|dip:DIP-39693N	refseq:NP_001028260.2|ensembl:ENSG00000182768(gene)|ensembl:ENST00000379095(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0016604"(nuclear body)|go:"GO:0019843"(rRNA binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0045171"(intercellular bridge)|go:"GO:0070131"(positive regulation of mitochondrial translation)|go:"GO:0072686"(mitotic spindle)|interpro:IPR010487(Neugrin)|mint:Q9NPE2	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:qae3zQwGP5R/+WCWoeahDKZ/9Jg9606	rogid:B0tJk1JglYD2jh37lUDOKV0qEBg9606	rigid:MvsfXEQRkUbct0FIHwGnQuvN/fc	false	sufficient binding region:245-446	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q8IZP0	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-375446|uniprotkb:O15147|uniprotkb:O76049|uniprotkb:O95060|uniprotkb:Q5W070|uniprotkb:Q5W072|uniprotkb:Q8TB63|uniprotkb:Q96S81|uniprotkb:Q9NXZ9|uniprotkb:Q9NYB8|intact:EBI-28968938|ensembl:ENSP00000365312|uniprotkb:A9Z1Y6|uniprotkb:Q5T2R3|uniprotkb:Q5T2R4|uniprotkb:Q5T2R6|uniprotkb:Q5T2R7|uniprotkb:B4DQ58|uniprotkb:Q5T2R9|uniprotkb:B3KX62|uniprotkb:H7BXI6	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:abi1_human(display_long)|uniprotkb:ABI1(gene name)|psi-mi:ABI1(display_short)|uniprotkb:SSH3BP1(gene name synonym)|uniprotkb:Abelson interactor 1(gene name synonym)|uniprotkb:Spectrin SH3 domain-binding protein 1(gene name synonym)|uniprotkb:Eps8 SH3 domain-binding protein(gene name synonym)|uniprotkb:e3B1(gene name synonym)|uniprotkb:Nap1-binding protein(gene name synonym)|uniprotkb:Abl-binding protein 4(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509756|imex:IM-28561-849	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_001012768.1|refseq:NP_001012769.1|refseq:NP_001012770.1|refseq:NP_001171590.1|refseq:NP_001171591.1|go:"GO:0030027"(lamellipodium)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0030426"(growth cone)|go:"GO:0031209"(SCAR complex)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045296"(cadherin binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072673"(lamellipodium morphogenesis)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028456|interpro:IPR028457|interpro:IPR035725|interpro:IPR036028|mint:Q8IZP0|ensembl:ENST00000376142(transcript)|go:"GO:0001756"(somitogenesis)|ensembl:ENSG00000136754(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|refseq:NP_001171592.1|refseq:NP_001171593.1|refseq:NP_001171594.1|refseq:NP_001171595.1|refseq:NP_005461.2|ensembl:ENST00000346832|ensembl:ENSP00000279599|ensembl:ENST00000359188|ensembl:ENSP00000352114|ensembl:ENST00000376137|ensembl:ENSP00000365307|ensembl:ENST00000376138|ensembl:ENSP00000365308|ensembl:ENST00000376139|ensembl:ENSP00000365309|ensembl:ENST00000376140|ensembl:ENSP00000365310|ensembl:ENSP00000365312|ensembl:ENST00000376166|ensembl:ENSP00000365336|ensembl:ENST00000376170|ensembl:ENSP00000365340|ensembl:ENST00000490841|ensembl:ENSP00000440101|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9664422|refseq:NP_001171596.1|refseq:NP_001171587.1|dip:DIP-31118N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:mO2D5R8ZlYmsh+fXdJpaHZOssfs9606	rigid:+8UvUFHfwS6o5GoqRufax39nrv4	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q06787	uniprotkb:P09972	intact:EBI-366305|ensembl:ENSP00000359506|uniprotkb:Q5PQZ6|uniprotkb:Q16578|uniprotkb:Q99054|uniprotkb:A6NNH4|uniprotkb:D3DWT0|uniprotkb:D3DWT1|uniprotkb:D3DWT2|uniprotkb:G8JL90	intact:EBI-2952751|ensembl:ENSP00000226253|ensembl:ENSP00000378731|uniprotkb:Q6P0L5|uniprotkb:Q3SYL3|uniprotkb:Q6FH94|uniprotkb:B2R5R3	psi-mi:fmr1_human(display_long)|uniprotkb:FMR1(gene name)|psi-mi:FMR1(display_short)|uniprotkb:Fragile X mental retardation protein 1(gene name synonym)	psi-mi:aldoc_human(display_long)|uniprotkb:ALDOC(gene name)|psi-mi:ALDOC(display_short)|uniprotkb:ALDC(gene name synonym)|uniprotkb:Brain-type aldolase(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509515|imex:IM-28561-1767	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000102081(gene)|ensembl:ENST00000370475(transcript)|refseq:NP_001172004.1|refseq:NP_001172005.1|refseq:NP_001172010.1|refseq:NP_001172011.1|refseq:NP_002015.1|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990812"(growth cone filopodium)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q06787|rcsb pdb:2BKD|rcsb pdb:2FMR|rcsb pdb:2LA5|rcsb pdb:2QND|rcsb pdb:4OVA|rcsb pdb:4QVZ|rcsb pdb:4QW2|rcsb pdb:5DE5|rcsb pdb:5DE8|rcsb pdb:5DEA|rcsb pdb:5UWJ|rcsb pdb:5UWO|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032196|interpro:IPR036612|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|dip:DIP-29509N	interpro:IPR000741(Fructose-bisphosphate aldolase, class-I)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR029768|mint:P09972|rcsb pdb:1XFB|reactome:R-HSA-6798695|reactome:R-HSA-70171|reactome:R-HSA-70263|ensembl:ENSG00000109107(gene)|ensembl:ENST00000226253(transcript)|ensembl:ENST00000395321(transcript)|go:"GO:0004332"(fructose-bisphosphate aldolase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006000"(fructose metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|refseq:NP_005156.1|refseq:XP_011522858.1|refseq:XP_005258006.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:+iN/J/MbxTcRwgDezYseEDwLep49606	rogid:0ZRiaxKG2+jvyJw6MHu1cWGFEhk9606	rigid:BqMCTXW3qE1ytWywnxPzy3cWM0o	false	sufficient binding region:210-431	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O15409	uniprotkb:Q16650	intact:EBI-983612|uniprotkb:A0AUV6|uniprotkb:A4D0U8|uniprotkb:Q6ZND1|uniprotkb:Q75MJ3|uniprotkb:Q8IZE0|uniprotkb:Q8N0W2|uniprotkb:Q8N6B7|uniprotkb:Q8N6B8|uniprotkb:Q8NFQ1|uniprotkb:Q8NFQ2|uniprotkb:Q8NFQ3|uniprotkb:Q8NFQ4|uniprotkb:Q8TD74|ensembl:ENSP00000265436|ensembl:ENSP00000377132|uniprotkb:A6NNW4|uniprotkb:B4DLD9	intact:EBI-1047158|ensembl:ENSP00000374205|uniprotkb:Q14DC5|uniprotkb:Q53TH0|uniprotkb:B2R6G5|uniprotkb:Q56A81|uniprotkb:B0AZS4	psi-mi:foxp2_human(display_long)|uniprotkb:CAG repeat protein 44(gene name synonym)|uniprotkb:Trinucleotide repeat-containing gene 10 protein(gene name synonym)|uniprotkb:FOXP2(gene name)|psi-mi:FOXP2(display_short)|uniprotkb:CAGH44(gene name synonym)|uniprotkb:TNRC10(gene name synonym)	psi-mi:tbr1_human(display_long)|uniprotkb:TES-56(gene name synonym)|uniprotkb:TBR1(gene name)|psi-mi:TBR1(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509738|imex:IM-28561-1773	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000128573(gene)|ensembl:ENST00000350908(transcript)|ensembl:ENST00000393494(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0021757"(caudate nucleus development)|go:"GO:0021758"(putamen development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0033574"(response to testosterone)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0098582"(innate vocalization behavior)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR030456|interpro:IPR032354|interpro:IPR036388|interpro:IPR036390|mint:O15409|rcsb pdb:2A07|rcsb pdb:2AS5|go:"GO:0046872"(metal ion binding)|refseq:NP_001166237.1|refseq:NP_001166238.1|refseq:NP_055306.1|refseq:NP_683696.2|refseq:NP_683697.2|refseq:NP_683698.2|dip:DIP-29004N|refseq:XP_016868290.1	refseq:NP_006584.1|ensembl:ENSG00000136535(gene)|ensembl:ENST00000389554(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1902667"(regulation of axon guidance)|go:"GO:0001708"(cell fate specification)|go:"GO:0001947"(heart looping)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007420"(brain development)|go:"GO:0010092"(specification of animal organ identity)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021764"(amygdala development)|go:"GO:0021902"(commitment of neuronal cell to specific neuron type in forebrain)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030902"(hindbrain development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR001699(Transcription factor, T-box)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR018186|interpro:IPR032385|interpro:IPR036960|mint:Q16650	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:XRN9auLs2qtK6W3mjHJHAQPbO9s9606	rogid:qD1euHkX/welvC2klFM95IiAiWE9606	rigid:GKPLo+JA0SpUB7ctOWWE05nT5Vg	false	sufficient binding region:122-382	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O15409	uniprotkb:Q9Y6X2	intact:EBI-983612|uniprotkb:A0AUV6|uniprotkb:A4D0U8|uniprotkb:Q6ZND1|uniprotkb:Q75MJ3|uniprotkb:Q8IZE0|uniprotkb:Q8N0W2|uniprotkb:Q8N6B7|uniprotkb:Q8N6B8|uniprotkb:Q8NFQ1|uniprotkb:Q8NFQ2|uniprotkb:Q8NFQ3|uniprotkb:Q8NFQ4|uniprotkb:Q8TD74|ensembl:ENSP00000265436|ensembl:ENSP00000377132|uniprotkb:A6NNW4|uniprotkb:B4DLD9	intact:EBI-2803703|uniprotkb:Q9UFI3|intact:EBI-28970301|ensembl:ENSP00000376765	psi-mi:foxp2_human(display_long)|uniprotkb:CAG repeat protein 44(gene name synonym)|uniprotkb:Trinucleotide repeat-containing gene 10 protein(gene name synonym)|uniprotkb:FOXP2(gene name)|psi-mi:FOXP2(display_short)|uniprotkb:CAGH44(gene name synonym)|uniprotkb:TNRC10(gene name synonym)	psi-mi:pias3_human(display_long)|uniprotkb:Protein inhibitor of activated STAT protein 3(gene name synonym)|uniprotkb:PIAS3(gene name)|psi-mi:PIAS3(display_short)|uniprotkb:E3 SUMO-protein transferase PIAS3(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509729|imex:IM-28561-381	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000128573(gene)|ensembl:ENST00000350908(transcript)|ensembl:ENST00000393494(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0021757"(caudate nucleus development)|go:"GO:0021758"(putamen development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0033574"(response to testosterone)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0098582"(innate vocalization behavior)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR030456|interpro:IPR032354|interpro:IPR036388|interpro:IPR036390|mint:O15409|rcsb pdb:2A07|rcsb pdb:2AS5|go:"GO:0046872"(metal ion binding)|refseq:NP_001166237.1|refseq:NP_001166238.1|refseq:NP_055306.1|refseq:NP_683696.2|refseq:NP_683697.2|refseq:NP_683698.2|dip:DIP-29004N|refseq:XP_016868290.1	ensembl:ENSP00000376765|ensembl:ENSG00000131788(gene)|ensembl:ENST00000393045(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009725"(response to hormone)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030425"(dendrite)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0045202"(synapse)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045838"(positive regulation of membrane potential)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061665"(SUMO ligase activity)|go:"GO:0071847"(TNFSF11-mediated signaling pathway)|interpro:IPR003034(DNA-binding SAP)|interpro:IPR004181(Zinc finger, MIZ-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR023321|interpro:IPR027226|interpro:IPR036361|interpro:IPR038654|mint:Q9Y6X2|rcsb pdb:4MVT|reactome:R-HSA-3232118|reactome:R-HSA-3899300|reactome:R-HSA-4090294|reactome:R-HSA-4615885|reactome:R-HSA-4755510|reactome:R-HSA-5696395|go:"GO:0016925"(protein sumoylation)|refseq:NP_006090.2|dip:DIP-5969N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:XRN9auLs2qtK6W3mjHJHAQPbO9s9606	rogid:uAxtGVgFcpm5yJL1rul8vVciHZA9606	rigid:85sYf4VrBKxCDrMr5sZZeLXUnvM	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O15409	uniprotkb:P56545	intact:EBI-983612|uniprotkb:A0AUV6|uniprotkb:A4D0U8|uniprotkb:Q6ZND1|uniprotkb:Q75MJ3|uniprotkb:Q8IZE0|uniprotkb:Q8N0W2|uniprotkb:Q8N6B7|uniprotkb:Q8N6B8|uniprotkb:Q8NFQ1|uniprotkb:Q8NFQ2|uniprotkb:Q8NFQ3|uniprotkb:Q8NFQ4|uniprotkb:Q8TD74|ensembl:ENSP00000265436|ensembl:ENSP00000377132|uniprotkb:A6NNW4|uniprotkb:B4DLD9	intact:EBI-741533|uniprotkb:O43449|uniprotkb:Q5SQP7|uniprotkb:Q69YI3|uniprotkb:Q86SV0|uniprotkb:Q9H2T8|uniprotkb:A8K2X5|ensembl:ENSP00000338615|ensembl:ENSP00000410474|ensembl:ENSP00000434630|ensembl:ENSP00000436285|uniprotkb:D3DRF5|uniprotkb:Q8IY44|intact:EBI-11742664	psi-mi:foxp2_human(display_long)|uniprotkb:CAG repeat protein 44(gene name synonym)|uniprotkb:Trinucleotide repeat-containing gene 10 protein(gene name synonym)|uniprotkb:FOXP2(gene name)|psi-mi:FOXP2(display_short)|uniprotkb:CAGH44(gene name synonym)|uniprotkb:TNRC10(gene name synonym)	psi-mi:ctbp2_human(display_long)|uniprotkb:CTBP2(gene name)|psi-mi:CTBP2(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509720|imex:IM-28561-1319	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000128573(gene)|ensembl:ENST00000350908(transcript)|ensembl:ENST00000393494(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0021757"(caudate nucleus development)|go:"GO:0021758"(putamen development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0033574"(response to testosterone)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0098582"(innate vocalization behavior)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR030456|interpro:IPR032354|interpro:IPR036388|interpro:IPR036390|mint:O15409|rcsb pdb:2A07|rcsb pdb:2AS5|go:"GO:0046872"(metal ion binding)|refseq:NP_001166237.1|refseq:NP_001166238.1|refseq:NP_055306.1|refseq:NP_683696.2|refseq:NP_683697.2|refseq:NP_683698.2|dip:DIP-29004N|refseq:XP_016868290.1	refseq:NP_001077383.1|refseq:NP_001320.1|refseq:NP_073713.2|refseq:NP_001307943.1|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0098882"(structural constituent of presynaptic active zone)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR006139(D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region)|interpro:IPR006140(D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding)|interpro:IPR029753|interpro:IPR036291|interpro:IPR043322|mint:P56545|rcsb pdb:2OME|rcsb pdb:4LCJ|rcsb pdb:6WKW|reactome:R-HSA-4641265|reactome:R-HSA-5339700|reactome:R-HSA-9662360|go:"GO:0048386"(positive regulation of retinoic acid receptor signaling pathway)|go:"GO:0050872"(white fat cell differentiation)|go:"GO:0051287"(NAD binding)|go:"GO:0098684"(photoreceptor ribbon synapse)|ensembl:ENSG00000175029(gene)|ensembl:ENST00000337195(transcript)|ensembl:ENST00000411419(transcript)|ensembl:ENST00000494626(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0003682"(chromatin binding)|ensembl:ENST00000531469(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0016616"(oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019079"(viral genome replication)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035563"(positive regulation of chromatin binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|refseq:XP_011537653.1|refseq:XP_011537655.1|refseq:XP_011537656.1|refseq:XP_011537657.1|refseq:NP_001307941.1|refseq:NP_001307942.1|refseq:XP_005269618.1|refseq:XP_005269621.1|refseq:XP_005269624.1|refseq:XP_005269625.1|refseq:XP_005269626.1|refseq:XP_005269628.1|refseq:XP_005269629.1|refseq:NP_001277143.1|refseq:NP_001277144.1|refseq:XP_006717705.1|refseq:XP_016871245.1|refseq:XP_016871246.1|dip:DIP-42104N|refseq:XP_011537651.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:XRN9auLs2qtK6W3mjHJHAQPbO9s9606	rogid:6sKiqjMRW/ViEvTbQJoaUjgvZtc9606	rigid:0wCI0SAOPq4rwpHm3cMuoJQ6VC8	false	sufficient binding region:122-382	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O15409	uniprotkb:Q13363	intact:EBI-983612|uniprotkb:A0AUV6|uniprotkb:A4D0U8|uniprotkb:Q6ZND1|uniprotkb:Q75MJ3|uniprotkb:Q8IZE0|uniprotkb:Q8N0W2|uniprotkb:Q8N6B7|uniprotkb:Q8N6B8|uniprotkb:Q8NFQ1|uniprotkb:Q8NFQ2|uniprotkb:Q8NFQ3|uniprotkb:Q8NFQ4|uniprotkb:Q8TD74|ensembl:ENSP00000265436|ensembl:ENSP00000377132|uniprotkb:A6NNW4|uniprotkb:B4DLD9	intact:EBI-908846|uniprotkb:Q4W5N3|uniprotkb:Q7Z2Q5|ensembl:ENSP00000290921	psi-mi:foxp2_human(display_long)|uniprotkb:CAG repeat protein 44(gene name synonym)|uniprotkb:Trinucleotide repeat-containing gene 10 protein(gene name synonym)|uniprotkb:FOXP2(gene name)|psi-mi:FOXP2(display_short)|uniprotkb:CAGH44(gene name synonym)|uniprotkb:TNRC10(gene name synonym)	psi-mi:ctbp1_human(display_long)|uniprotkb:CTBP1(gene name)|psi-mi:CTBP1(display_short)|uniprotkb:CTBP(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509711|imex:IM-28561-651	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000128573(gene)|ensembl:ENST00000350908(transcript)|ensembl:ENST00000393494(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0021757"(caudate nucleus development)|go:"GO:0021758"(putamen development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0033574"(response to testosterone)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0098582"(innate vocalization behavior)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR030456|interpro:IPR032354|interpro:IPR036388|interpro:IPR036390|mint:O15409|rcsb pdb:2A07|rcsb pdb:2AS5|go:"GO:0046872"(metal ion binding)|refseq:NP_001166237.1|refseq:NP_001166238.1|refseq:NP_055306.1|refseq:NP_683696.2|refseq:NP_683697.2|refseq:NP_683698.2|dip:DIP-29004N|refseq:XP_016868290.1	refseq:NP_001012632.1|refseq:NP_001319.1|refseq:XP_016863253.1|refseq:XP_016863254.1|refseq:XP_016863255.1|refseq:XP_016863256.1|dip:DIP-24245N|ensembl:ENSG00000159692(gene)|ensembl:ENST00000290921(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006342"|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016616"(oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019079"(viral genome replication)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031065"(positive regulation of histone deacetylation)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0050872"(white fat cell differentiation)|go:"GO:0051287"(NAD binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0090241"(negative regulation of histone H4 acetylation)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR006139(D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region)|interpro:IPR006140(D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding)|interpro:IPR029752|interpro:IPR029753|interpro:IPR036291|interpro:IPR043322|mint:Q13363|rcsb pdb:1MX3|rcsb pdb:4LCE|rcsb pdb:4U6Q|rcsb pdb:4U6S|rcsb pdb:6CDF|rcsb pdb:6CDR|rcsb pdb:6V89|rcsb pdb:6V8A|rcsb pdb:7KWM|reactome:R-HSA-3769402|reactome:R-HSA-3899300|reactome:R-HSA-4641265|reactome:R-HSA-5339700	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:XRN9auLs2qtK6W3mjHJHAQPbO9s9606	rogid:hhYGrtcr0oAQW5x5LfNmxfuRNj49606	rigid:yNVNAniDAJwwhMOYcOFa4y6eYDY	false	sufficient binding region:122-382	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q06787	uniprotkb:Q9ULU4	intact:EBI-366305|ensembl:ENSP00000359506|uniprotkb:Q5PQZ6|uniprotkb:Q16578|uniprotkb:Q99054|uniprotkb:A6NNH4|uniprotkb:D3DWT0|uniprotkb:D3DWT1|uniprotkb:D3DWT2|uniprotkb:G8JL90	intact:EBI-765834|uniprotkb:Q13517|uniprotkb:Q4JJ94|uniprotkb:Q4JJ95|uniprotkb:Q5TH09|uniprotkb:Q6MZM1|uniprotkb:Q8WXC5|uniprotkb:Q9H1F3|uniprotkb:Q9H1F4|uniprotkb:Q9H1F5|uniprotkb:Q9H1L8|uniprotkb:Q9H1L9|uniprotkb:Q9H2G5|uniprotkb:Q9NYN3|uniprotkb:Q9UIX6|uniprotkb:Q2HXV7|uniprotkb:E1P5U5|uniprotkb:B7Z680|uniprotkb:Q2HXV2|uniprotkb:Q2HXV8|uniprotkb:Q2HXW0|uniprotkb:Q2HXW1|uniprotkb:Q2HXW2|uniprotkb:Q2HXV4|uniprotkb:Q2HXV9|uniprotkb:B3KVL2|uniprotkb:B7Z2A8|uniprotkb:B7Z3E0|uniprotkb:B7ZM62|uniprotkb:F5H0X3|uniprotkb:H7C0U2|uniprotkb:J3KPU3|uniprotkb:Q2HXV1|uniprotkb:Q2HXV3|uniprotkb:Q5TH11|ensembl:ENSP00000312237	psi-mi:fmr1_human(display_long)|uniprotkb:FMR1(gene name)|psi-mi:FMR1(display_short)|uniprotkb:Fragile X mental retardation protein 1(gene name synonym)	psi-mi:pkcb1_human(display_long)|uniprotkb:Rack7(gene name synonym)|uniprotkb:Cutaneous T-cell lymphoma-associated antigen se14-3(gene name synonym)|uniprotkb:Zinc finger MYND domain-containing protein 8(gene name synonym)|uniprotkb:ZMYND8(gene name)|psi-mi:ZMYND8(display_short)|uniprotkb:KIAA1125(gene name synonym)|uniprotkb:RACK7(gene name synonym)|uniprotkb:PRKCBP1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509702|imex:IM-28561-631	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000102081(gene)|ensembl:ENST00000370475(transcript)|refseq:NP_001172004.1|refseq:NP_001172005.1|refseq:NP_001172010.1|refseq:NP_001172011.1|refseq:NP_002015.1|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990812"(growth cone filopodium)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q06787|rcsb pdb:2BKD|rcsb pdb:2FMR|rcsb pdb:2LA5|rcsb pdb:2QND|rcsb pdb:4OVA|rcsb pdb:4QVZ|rcsb pdb:4QW2|rcsb pdb:5DE5|rcsb pdb:5DE8|rcsb pdb:5DEA|rcsb pdb:5UWJ|rcsb pdb:5UWO|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032196|interpro:IPR036612|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|dip:DIP-29509N	refseq:NP_036540.3|refseq:NP_898868.1|refseq:NP_898869.1|refseq:XP_011527053.1|refseq:NP_001268711.1|refseq:NP_001268706.1|refseq:NP_001268710.1|ensembl:ENST00000262975|ensembl:ENSP00000262975|ensembl:ENSP00000312237|ensembl:ENST00000352431|ensembl:ENSP00000335537|ensembl:ENST00000355972|ensembl:ENSP00000348246|ensembl:ENST00000360911|ensembl:ENSP00000354166|ensembl:ENST00000372023|ensembl:ENSP00000361093|ensembl:ENST00000396281|ensembl:ENSP00000379577|refseq:NP_001268702.1|refseq:NP_001268703.1|refseq:NP_001268704.1|refseq:NP_001268705.1|refseq:NP_001268707.1|refseq:NP_001268712.1|refseq:XP_005260417.1|refseq:XP_005260423.1|ensembl:ENST00000446994|ensembl:ENSP00000396725|ensembl:ENST00000458360|ensembl:ENSP00000392964|ensembl:ENST00000461685|ensembl:ENSP00000418210|ensembl:ENST00000471951|ensembl:ENSP00000420095|ensembl:ENST00000536340|ensembl:ENSP00000439800|ensembl:ENST00000540497|ensembl:ENSP00000443086|refseq:NP_001268713.1|refseq:XP_005260413.1|refseq:NP_001268700.1|refseq:NP_001268701.1|refseq:XP_006723825.1|refseq:XP_016883250.1|refseq:XP_016883256.1|refseq:XP_016883257.1|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0035064"(methylated histone binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:0098815"(modulation of excitatory postsynaptic potential)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902897"(regulation of postsynaptic density protein 95 clustering)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|interpro:IPR000313(PWWP)|interpro:IPR001487(Bromodomain)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002893(Zinc finger, MYND-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR021931|interpro:IPR035505|interpro:IPR036427|interpro:IPR037967|interpro:IPR044075|mint:Q9ULU4|rcsb pdb:4COS|rcsb pdb:5B73|rcsb pdb:5MQ4|go:"GO:0005654"(nucleoplasm)|rcsb pdb:5Y1Z|ensembl:ENSG00000101040(gene)|ensembl:ENST00000311275(transcript)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:+iN/J/MbxTcRwgDezYseEDwLep49606	rogid:z46jFcDnmKauE75GMeApPZmfdDM9606	rigid:gQG54m9FwNDI+tT0MHCGnHn8op8	false	sufficient binding region:210-431	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q06787	uniprotkb:Q8WW38	intact:EBI-366305|ensembl:ENSP00000359506|uniprotkb:Q5PQZ6|uniprotkb:Q16578|uniprotkb:Q99054|uniprotkb:A6NNH4|uniprotkb:D3DWT0|uniprotkb:D3DWT1|uniprotkb:D3DWT2|uniprotkb:G8JL90	intact:EBI-947213|uniprotkb:Q32MA6|uniprotkb:Q9NPL7|uniprotkb:Q9NPS4|uniprotkb:Q9UNI5|ensembl:ENSP00000384179	psi-mi:fmr1_human(display_long)|uniprotkb:FMR1(gene name)|psi-mi:FMR1(display_short)|uniprotkb:Fragile X mental retardation protein 1(gene name synonym)	psi-mi:fog2_human(display_long)|uniprotkb:ZFPM2(gene name)|psi-mi:ZFPM2(display_short)|uniprotkb:FOG2(gene name synonym)|uniprotkb:Zinc finger protein multitype 2(gene name synonym)|uniprotkb:Friend of GATA protein 2(gene name synonym)|uniprotkb:ZNF89B(gene name synonym)|uniprotkb:Zinc finger protein 89B(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509693|imex:IM-28561-1317	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000102081(gene)|ensembl:ENST00000370475(transcript)|refseq:NP_001172004.1|refseq:NP_001172005.1|refseq:NP_001172010.1|refseq:NP_001172011.1|refseq:NP_002015.1|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990812"(growth cone filopodium)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q06787|rcsb pdb:2BKD|rcsb pdb:2FMR|rcsb pdb:2LA5|rcsb pdb:2QND|rcsb pdb:4OVA|rcsb pdb:4QVZ|rcsb pdb:4QW2|rcsb pdb:5DE5|rcsb pdb:5DE8|rcsb pdb:5DEA|rcsb pdb:5UWJ|rcsb pdb:5UWO|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032196|interpro:IPR036612|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|dip:DIP-29509N	refseq:NP_036214.2|ensembl:ENSG00000169946(gene)|ensembl:ENST00000407775(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003221"(right ventricular cardiac muscle tissue morphogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0007506"(gonadal mesoderm development)|go:"GO:0007507"(heart development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048568"(embryonic organ development)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:2000020"(positive regulation of male gonad development)|go:"GO:2000195"(negative regulation of female gonad development)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR034731|interpro:IPR036236|interpro:IPR039746|mint:Q8WW38|reactome:R-HSA-9690406|reactome:R-HSA-983231	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:+iN/J/MbxTcRwgDezYseEDwLep49606	rogid:FWix1ZWjYT7tMDfaS5p10SJ7mE49606	rigid:wcYu3ZHEiMPLOX2rDtKS5evfj70	false	sufficient binding region:210-431	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q06787	uniprotkb:O95359	intact:EBI-366305|ensembl:ENSP00000359506|uniprotkb:Q5PQZ6|uniprotkb:Q16578|uniprotkb:Q99054|uniprotkb:A6NNH4|uniprotkb:D3DWT0|uniprotkb:D3DWT1|uniprotkb:D3DWT2|uniprotkb:G8JL90	intact:EBI-720382|uniprotkb:Q4VXL6|uniprotkb:Q4VXL7|uniprotkb:Q5U5T7|uniprotkb:Q86WG6|uniprotkb:Q86WG7|uniprotkb:Q4VXL0|uniprotkb:Q4VXL3|uniprotkb:Q8TCK9|uniprotkb:Q9BVQ1|uniprotkb:Q9NZ41|uniprotkb:Q9NZR5|intact:EBI-2558151|intact:EBI-28968297|ensembl:ENSP00000334280|ensembl:ENSP00000358001	psi-mi:fmr1_human(display_long)|uniprotkb:FMR1(gene name)|psi-mi:FMR1(display_short)|uniprotkb:Fragile X mental retardation protein 1(gene name synonym)	psi-mi:tacc2_human(display_long)|uniprotkb:Anti-Zuai-1(gene name synonym)|uniprotkb:TACC2(gene name)|psi-mi:TACC2(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509686|imex:IM-28561-847	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000102081(gene)|ensembl:ENST00000370475(transcript)|refseq:NP_001172004.1|refseq:NP_001172005.1|refseq:NP_001172010.1|refseq:NP_001172011.1|refseq:NP_002015.1|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990812"(growth cone filopodium)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q06787|rcsb pdb:2BKD|rcsb pdb:2FMR|rcsb pdb:2LA5|rcsb pdb:2QND|rcsb pdb:4OVA|rcsb pdb:4QVZ|rcsb pdb:4QW2|rcsb pdb:5DE5|rcsb pdb:5DE8|rcsb pdb:5DEA|rcsb pdb:5UWJ|rcsb pdb:5UWO|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032196|interpro:IPR036612|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|dip:DIP-29509N	refseq:NP_001278807.1|refseq:NP_996744.3|refseq:NP_008928.1|refseq:NP_996742.1|refseq:NP_996743.1|ensembl:ENST00000260733|ensembl:ENSP00000260733|ensembl:ENSP00000334280|ensembl:ENST00000358010|ensembl:ENSP00000350701|ensembl:ENST00000360561|ensembl:ENSP00000353763|ensembl:ENST00000369000|ensembl:ENSP00000357996|ensembl:ENSP00000358001|ensembl:ENST00000513429|ensembl:ENSP00000425062|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0021987"(cerebral cortex development)|interpro:IPR007707(Transforming acidic coiled-coil-containing)|interpro:IPR039915|mint:O95359|go:"GO:0008283"(cell population proliferation)|ensembl:ENSG00000138162(gene)|ensembl:ENST00000334433(transcript)|ensembl:ENST00000369005(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007052"(mitotic spindle organization)	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:+iN/J/MbxTcRwgDezYseEDwLep49606	rogid:F497RHDDNDqTPKybxJ/DiuhfjAc9606	rigid:4xYhmzggJ/+y0WTZ1RCLLu4lNMQ	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q06787	uniprotkb:Q9H0F6	intact:EBI-366305|ensembl:ENSP00000359506|uniprotkb:Q5PQZ6|uniprotkb:Q16578|uniprotkb:Q99054|uniprotkb:A6NNH4|uniprotkb:D3DWT0|uniprotkb:D3DWT1|uniprotkb:D3DWT2|uniprotkb:G8JL90	intact:EBI-3942966|uniprotkb:D3DWL3|uniprotkb:Q8IXF5|uniprotkb:Q8IXF6|uniprotkb:A6NEG3|uniprotkb:Q8TB25|uniprotkb:Q9BUE4|uniprotkb:Q8N2E7|uniprotkb:C0L3L2|ensembl:ENSP00000381698	psi-mi:fmr1_human(display_long)|uniprotkb:FMR1(gene name)|psi-mi:FMR1(display_short)|uniprotkb:Fragile X mental retardation protein 1(gene name synonym)	psi-mi:shrpn_human(display_long)|uniprotkb:SHARPIN(gene name)|psi-mi:SHARPIN(display_short)|uniprotkb:SIPL1(gene name synonym)|uniprotkb:Shank-associated RH domain-interacting protein(gene name synonym)|uniprotkb:Shank-interacting protein-like 1(gene name synonym)|uniprotkb:PSEC0216(orf name)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509677|imex:IM-28561-1069	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000102081(gene)|ensembl:ENST00000370475(transcript)|refseq:NP_001172004.1|refseq:NP_001172005.1|refseq:NP_001172010.1|refseq:NP_001172011.1|refseq:NP_002015.1|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990812"(growth cone filopodium)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q06787|rcsb pdb:2BKD|rcsb pdb:2FMR|rcsb pdb:2LA5|rcsb pdb:2QND|rcsb pdb:4OVA|rcsb pdb:4QVZ|rcsb pdb:4QW2|rcsb pdb:5DE5|rcsb pdb:5DE8|rcsb pdb:5DEA|rcsb pdb:5UWJ|rcsb pdb:5UWO|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032196|interpro:IPR036612|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|dip:DIP-29509N	ensembl:ENSG00000179526(gene)|ensembl:ENST00000398712(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005829"(cytosol)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007420"(brain development)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030262"(apoptotic nuclear changes)|go:"GO:0030425"(dendrite)|go:"GO:0031424"(keratinization)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0071797"(LUBAC complex)|go:"GO:0097039"(protein linear polyubiquitination)|go:"GO:2000348"(regulation of CD40 signaling pathway)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR026261|reactome:R-HSA-6794361|interpro:IPR029071|interpro:IPR031912|interpro:IPR036443|mint:Q9H0F6|rcsb pdb:4EMO|rcsb pdb:5X0W|reactome:R-HSA-5357905|reactome:R-HSA-5357956|refseq:NP_112236.3|refseq:XP_016869377.1|dip:DIP-57842N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:+iN/J/MbxTcRwgDezYseEDwLep49606	rogid:+RGl3JO1zsGCdaInDn20yhNZs0E9606	rigid:yq+nz5+oOCmVA6kzeKEJtPEcx7Q	false	sufficient binding region:1-216,280-431	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q06787	uniprotkb:P23246	intact:EBI-366305|ensembl:ENSP00000359506|uniprotkb:Q5PQZ6|uniprotkb:Q16578|uniprotkb:Q99054|uniprotkb:A6NNH4|uniprotkb:D3DWT0|uniprotkb:D3DWT1|uniprotkb:D3DWT2|uniprotkb:G8JL90	intact:EBI-355453|uniprotkb:P30808|uniprotkb:Q5SZ71|ensembl:ENSP00000349748	psi-mi:fmr1_human(display_long)|uniprotkb:FMR1(gene name)|psi-mi:FMR1(display_short)|uniprotkb:Fragile X mental retardation protein 1(gene name synonym)	psi-mi:sfpq_human(display_long)|uniprotkb:SFPQ(gene name)|psi-mi:SFPQ(display_short)|uniprotkb:PSF(gene name synonym)|uniprotkb:Polypyrimidine tract-binding protein-associated-splicing factor(gene name synonym)|uniprotkb:DNA-binding p52/p100 complex, 100 kDa subunit(gene name synonym)|uniprotkb:100 kDa DNA-pairing protein(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509668|imex:IM-28561-1527	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000102081(gene)|ensembl:ENST00000370475(transcript)|refseq:NP_001172004.1|refseq:NP_001172005.1|refseq:NP_001172010.1|refseq:NP_001172011.1|refseq:NP_002015.1|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990812"(growth cone filopodium)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q06787|rcsb pdb:2BKD|rcsb pdb:2FMR|rcsb pdb:2LA5|rcsb pdb:2QND|rcsb pdb:4OVA|rcsb pdb:4QVZ|rcsb pdb:4QW2|rcsb pdb:5DE5|rcsb pdb:5DE8|rcsb pdb:5DEA|rcsb pdb:5UWJ|rcsb pdb:5UWO|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032196|interpro:IPR036612|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|dip:DIP-29509N	refseq:NP_005057.1|ensembl:ENSG00000116560(gene)|ensembl:ENST00000357214(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0016363"(nuclear matrix)|go:"GO:0003723"(RNA binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0042382"(paraspeckles)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0005634"(nucleus)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045876"(positive regulation of sister chromatid cohesion)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0048511"(rhythmic process)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0098963"(dendritic transport of messenger ribonucleoprotein complex)|go:"GO:1902177"(positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:0006355"(regulation of transcription, DNA-templated)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR012975(NOPS)|interpro:IPR034525|interpro:IPR034526|interpro:IPR035979|mint:P23246|rcsb pdb:4WII|rcsb pdb:4WIJ|rcsb pdb:4WIK|rcsb pdb:5WPA|rcsb pdb:6NCQ|rcsb pdb:6OWJ|rcsb pdb:6WMZ|rcsb pdb:7LRQ|rcsb pdb:7LRU|reactome:R-HSA-8849468|reactome:R-HSA-9635465|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|refseq:XP_005271169.1|refseq:XP_005271170.1|refseq:XP_005271172.1|refseq:XP_016857542.1|refseq:XP_016857543.1|dip:DIP-31272N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:+iN/J/MbxTcRwgDezYseEDwLep49606	rogid:B7mSc6tthLbSHo0qz0SMZBSl3HA9606	rigid:VMatS02i0Ht3IHz7I2PdxR5hk8Y	false	sufficient binding region:280-431	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q06787	uniprotkb:P61289	intact:EBI-366305|ensembl:ENSP00000359506|uniprotkb:Q5PQZ6|uniprotkb:Q16578|uniprotkb:Q99054|uniprotkb:A6NNH4|uniprotkb:D3DWT0|uniprotkb:D3DWT1|uniprotkb:D3DWT2|uniprotkb:G8JL90	intact:EBI-355546|uniprotkb:O35563|uniprotkb:P97373|uniprotkb:Q12920|uniprotkb:Q13172|uniprotkb:Q9BQD9|uniprotkb:A8K9A3|ensembl:ENSP00000466794	psi-mi:fmr1_human(display_long)|uniprotkb:FMR1(gene name)|psi-mi:FMR1(display_short)|uniprotkb:Fragile X mental retardation protein 1(gene name synonym)	psi-mi:psme3_human(display_long)|uniprotkb:PSME3(gene name)|psi-mi:PSME3(display_short)|uniprotkb:Proteasome activator 28 subunit gamma(gene name synonym)|uniprotkb:Activator of multicatalytic protease subunit 3(gene name synonym)|uniprotkb:11S regulator complex subunit gamma(gene name synonym)|uniprotkb:Ki nuclear autoantigen(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509659|imex:IM-28561-1315	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000102081(gene)|ensembl:ENST00000370475(transcript)|refseq:NP_001172004.1|refseq:NP_001172005.1|refseq:NP_001172010.1|refseq:NP_001172011.1|refseq:NP_002015.1|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990812"(growth cone filopodium)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q06787|rcsb pdb:2BKD|rcsb pdb:2FMR|rcsb pdb:2LA5|rcsb pdb:2QND|rcsb pdb:4OVA|rcsb pdb:4QVZ|rcsb pdb:4QW2|rcsb pdb:5DE5|rcsb pdb:5DE8|rcsb pdb:5DEA|rcsb pdb:5UWJ|rcsb pdb:5UWO|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032196|interpro:IPR036612|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|dip:DIP-29509N	refseq:NP_005780.2|refseq:NP_789839.1|ensembl:ENSG00000131467(gene)|ensembl:ENST00000590720(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0002039"(p53 binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008537"(proteasome activator complex)|go:"GO:0010950"(positive regulation of endopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR003185(Proteasome activator pa28, REG alpha subunit)|interpro:IPR003186(Proteasome activator pa28, REG beta subunit)|interpro:IPR009077(Proteasome activator pa28, REG alpha/beta subunit)|interpro:IPR036252|interpro:IPR036996|interpro:IPR036997|mint:P61289|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:+iN/J/MbxTcRwgDezYseEDwLep49606	rogid:6EQY2Kj3Juf++m4eBDzPWMgbC2k9606	rigid:8qiC3HvHuN/RzY4RwGnx6HCELG4	false	sufficient binding region:280-431	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q06787	uniprotkb:Q9BZL4	intact:EBI-366305|ensembl:ENSP00000359506|uniprotkb:Q5PQZ6|uniprotkb:Q16578|uniprotkb:Q99054|uniprotkb:A6NNH4|uniprotkb:D3DWT0|uniprotkb:D3DWT1|uniprotkb:D3DWT2|uniprotkb:G8JL90	intact:EBI-721802|uniprotkb:Q59FK8|uniprotkb:Q6ZPD1|uniprotkb:Q7L8F7|uniprotkb:Q9H5H5|uniprotkb:Q9NT00|uniprotkb:Q96HW1|uniprotkb:B4DME2|ensembl:ENSP00000263433	psi-mi:fmr1_human(display_long)|uniprotkb:FMR1(gene name)|psi-mi:FMR1(display_short)|uniprotkb:Fragile X mental retardation protein 1(gene name synonym)	psi-mi:pp12c_human(display_long)|uniprotkb:LENG3(gene name synonym)|uniprotkb:MBS85(gene name synonym)|uniprotkb:Protein phosphatase 1 myosin-binding subunit of 85 kDa(gene name synonym)|uniprotkb:PPP1R12C(gene name)|psi-mi:PPP1R12C(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509650|imex:IM-28561-1313	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000102081(gene)|ensembl:ENST00000370475(transcript)|refseq:NP_001172004.1|refseq:NP_001172005.1|refseq:NP_001172010.1|refseq:NP_001172011.1|refseq:NP_002015.1|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990812"(growth cone filopodium)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q06787|rcsb pdb:2BKD|rcsb pdb:2FMR|rcsb pdb:2LA5|rcsb pdb:2QND|rcsb pdb:4OVA|rcsb pdb:4QVZ|rcsb pdb:4QW2|rcsb pdb:5DE5|rcsb pdb:5DE8|rcsb pdb:5DEA|rcsb pdb:5UWJ|rcsb pdb:5UWO|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032196|interpro:IPR036612|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|dip:DIP-29509N	refseq:NP_060077.1|refseq:NP_001258547.1|refseq:XP_005259070.1|ensembl:ENSG00000125503(gene)|ensembl:ENST00000263433(transcript)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007165"(signal transduction)|go:"GO:0019208"(phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|interpro:IPR002110(Ankyrin)|interpro:IPR017401(Protein phosphatase 1, regulatory subunits 12A/B/C, eukaryote)|interpro:IPR020683|interpro:IPR031205|interpro:IPR031775|interpro:IPR036770|mint:Q9BZL4	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:+iN/J/MbxTcRwgDezYseEDwLep49606	rogid:q24mbt02IydCWtQyNXmNVWav/i89606	rigid:oWesWTKsuRv+hPb5OYV0YTyOpjY	false	sufficient binding region:280-431	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q06787	uniprotkb:Q9NRD5	intact:EBI-366305|ensembl:ENSP00000359506|uniprotkb:Q5PQZ6|uniprotkb:Q16578|uniprotkb:Q99054|uniprotkb:A6NNH4|uniprotkb:D3DWT0|uniprotkb:D3DWT1|uniprotkb:D3DWT2|uniprotkb:G8JL90	intact:EBI-79165|uniprotkb:O95906|ensembl:ENSP00000349465|ensembl:ENSP00000385205|intact:EBI-2622151|uniprotkb:B3KS52	psi-mi:fmr1_human(display_long)|uniprotkb:FMR1(gene name)|psi-mi:FMR1(display_short)|uniprotkb:Fragile X mental retardation protein 1(gene name synonym)	psi-mi:pick1_human(display_long)|uniprotkb:PICK1(gene name)|psi-mi:PICK1(display_short)|uniprotkb:PRKCABP(gene name synonym)|uniprotkb:Protein kinase C-alpha-binding protein(gene name synonym)|uniprotkb:Protein interacting with C kinase 1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509641|imex:IM-28561-1311	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000102081(gene)|ensembl:ENST00000370475(transcript)|refseq:NP_001172004.1|refseq:NP_001172005.1|refseq:NP_001172010.1|refseq:NP_001172011.1|refseq:NP_002015.1|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990812"(growth cone filopodium)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q06787|rcsb pdb:2BKD|rcsb pdb:2FMR|rcsb pdb:2LA5|rcsb pdb:2QND|rcsb pdb:4OVA|rcsb pdb:4QVZ|rcsb pdb:4QW2|rcsb pdb:5DE5|rcsb pdb:5DE8|rcsb pdb:5DEA|rcsb pdb:5UWJ|rcsb pdb:5UWO|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032196|interpro:IPR036612|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|dip:DIP-29509N	ensembl:ENSG00000100151(gene)|ensembl:ENST00000356976(transcript)|ensembl:ENST00000404072(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|refseq:NP_001034672.1|refseq:NP_001034673.1|refseq:NP_036539.1|go:"GO:0015844"(monoamine transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021782"(glial cell development)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0034315"(regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0034316"(negative regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0036294"(cellular response to decreased oxygen levels)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0043113"(receptor clustering)|go:"GO:0045161"(neuronal ion channel clustering)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051015"(actin filament binding)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0098842"(postsynaptic early endosome)|go:"GO:0140090"(membrane curvature sensor activity)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR010504(Arfaptin-like)|interpro:IPR027267|interpro:IPR030798|interpro:IPR036034|interpro:IPR037959|mint:Q9NRD5|rcsb pdb:2GZV|rcsb pdb:6AR4|rcsb pdb:6BJN|rcsb pdb:6BJO|reactome:R-HSA-202733|reactome:R-HSA-416993	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:+iN/J/MbxTcRwgDezYseEDwLep49606	rogid:qRx+eNG7We8Oe0SQOekqpJpn8zk9606	rigid:6FY+MSISeeKRZcIN1f1yDwnqWjY	false	sufficient binding region:280-431	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q06787	uniprotkb:Q7Z6G3	intact:EBI-366305|ensembl:ENSP00000359506|uniprotkb:Q5PQZ6|uniprotkb:Q16578|uniprotkb:Q99054|uniprotkb:A6NNH4|uniprotkb:D3DWT0|uniprotkb:D3DWT1|uniprotkb:D3DWT2|uniprotkb:G8JL90	intact:EBI-950070|ensembl:ENSP00000307449|uniprotkb:A2RRG3|uniprotkb:O75547|uniprotkb:Q6ZSK0|uniprotkb:H3BTW2	psi-mi:fmr1_human(display_long)|uniprotkb:FMR1(gene name)|psi-mi:FMR1(display_short)|uniprotkb:Fragile X mental retardation protein 1(gene name synonym)	psi-mi:neca2_human(display_long)|uniprotkb:Neuronal calcium-binding protein 2(gene name synonym)|uniprotkb:Synaptotagmin-interacting protein 2(gene name synonym)|uniprotkb:NECAB2(gene name)|psi-mi:NECAB2(display_short)|uniprotkb:EFCBP2(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509632|imex:IM-28561-1309	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000102081(gene)|ensembl:ENST00000370475(transcript)|refseq:NP_001172004.1|refseq:NP_001172005.1|refseq:NP_001172010.1|refseq:NP_001172011.1|refseq:NP_002015.1|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990812"(growth cone filopodium)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q06787|rcsb pdb:2BKD|rcsb pdb:2FMR|rcsb pdb:2LA5|rcsb pdb:2QND|rcsb pdb:4OVA|rcsb pdb:4QVZ|rcsb pdb:4QW2|rcsb pdb:5DE5|rcsb pdb:5DE8|rcsb pdb:5DEA|rcsb pdb:5UWJ|rcsb pdb:5UWO|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032196|interpro:IPR036612|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|dip:DIP-29509N	ensembl:ENSG00000103154(gene)|ensembl:ENST00000305202(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031687"(A2A adenosine receptor binding)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042984"(regulation of amyloid precursor protein biosynthetic process)|go:"GO:0060168"(positive regulation of adenosine receptor signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1904021"(negative regulation of G protein-coupled receptor internalization)|go:"GO:1905477"(positive regulation of protein localization to membrane)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR007138(Antibiotic biosynthesis monooxygenase)|interpro:IPR011008(Dimeric alpha-beta barrel)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR039862|mint:Q7Z6G3|refseq:NP_061938.2|refseq:NP_001316678.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:+iN/J/MbxTcRwgDezYseEDwLep49606	rogid:Op/JNOBupSCF1U3MCeNmJ6gUUrg9606	rigid:QUevU0maD6/nycWZJgjTZPVpodM	false	sufficient binding region:280-431	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q06787	uniprotkb:Q14764	intact:EBI-366305|ensembl:ENSP00000359506|uniprotkb:Q5PQZ6|uniprotkb:Q16578|uniprotkb:Q99054|uniprotkb:A6NNH4|uniprotkb:D3DWT0|uniprotkb:D3DWT1|uniprotkb:D3DWT2|uniprotkb:G8JL90	intact:EBI-2816254|uniprotkb:Q9BPW6|uniprotkb:Q9BQT1|uniprotkb:Q96BG4|uniprotkb:Q9UBD1|intact:EBI-28971732|ensembl:ENSP00000349977|ensembl:ENSP00000378760	psi-mi:fmr1_human(display_long)|uniprotkb:FMR1(gene name)|psi-mi:FMR1(display_short)|uniprotkb:Fragile X mental retardation protein 1(gene name synonym)	psi-mi:mvp_human(display_long)|uniprotkb:MVP(gene name)|psi-mi:MVP(display_short)|uniprotkb:LRP(gene name synonym)|uniprotkb:Lung resistance-related protein(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509623|imex:IM-28561-1067	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000102081(gene)|ensembl:ENST00000370475(transcript)|refseq:NP_001172004.1|refseq:NP_001172005.1|refseq:NP_001172010.1|refseq:NP_001172011.1|refseq:NP_002015.1|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990812"(growth cone filopodium)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q06787|rcsb pdb:2BKD|rcsb pdb:2FMR|rcsb pdb:2LA5|rcsb pdb:2QND|rcsb pdb:4OVA|rcsb pdb:4QVZ|rcsb pdb:4QW2|rcsb pdb:5DE5|rcsb pdb:5DE8|rcsb pdb:5DEA|rcsb pdb:5UWJ|rcsb pdb:5UWO|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032196|interpro:IPR036612|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|dip:DIP-29509N	ensembl:ENSP00000349977|ensembl:ENSP00000378760|refseq:NP_001280133.1|refseq:NP_001280134.1|refseq:NP_005106.2|refseq:NP_059447.2|ensembl:ENSG00000013364(gene)|ensembl:ENST00000357402(transcript)|ensembl:ENST00000395353(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005643"(nuclear pore)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051028"(mRNA transport)|go:"GO:0061099"(negative regulation of protein tyrosine kinase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002499(Major vault protein, N-terminal)|interpro:IPR021870|interpro:IPR036013|interpro:IPR039059|interpro:IPR040989|interpro:IPR041134|interpro:IPR041136|interpro:IPR041139|interpro:IPR043023|interpro:IPR043179|mint:Q14764|rcsb pdb:1Y7X|reactome:R-HSA-6798695	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:+iN/J/MbxTcRwgDezYseEDwLep49606	rogid:z/Hc6TeTzO5QSpZ8AUXiI2ox4eg9606	rigid:TlQ1A/GhnH1nlrqg4y/lQhqOWHY	false	sufficient binding region:280-431	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q06787	uniprotkb:Q5TCQ9	intact:EBI-366305|ensembl:ENSP00000359506|uniprotkb:Q5PQZ6|uniprotkb:Q16578|uniprotkb:Q99054|uniprotkb:A6NNH4|uniprotkb:D3DWT0|uniprotkb:D3DWT1|uniprotkb:D3DWT2|uniprotkb:G8JL90	intact:EBI-310506|uniprotkb:Q5TCR0|uniprotkb:Q9H2V6|uniprotkb:Q5TCQ8|uniprotkb:Q9H5Y8|uniprotkb:Q9HBC4|intact:EBI-2512710|intact:EBI-991068|ensembl:ENSP00000304604|uniprotkb:Q9HCD8|uniprotkb:A0A024R0E9|uniprotkb:A0A024R0H3	psi-mi:fmr1_human(display_long)|uniprotkb:FMR1(gene name)|psi-mi:FMR1(display_short)|uniprotkb:Fragile X mental retardation protein 1(gene name synonym)	psi-mi:magi3_human(display_long)|uniprotkb:MAGI3(gene name)|psi-mi:MAGI3(display_short)|uniprotkb:KIAA1634(gene name synonym)|uniprotkb:Membrane-associated guanylate kinase inverted 3(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509614|imex:IM-28561-1771	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000102081(gene)|ensembl:ENST00000370475(transcript)|refseq:NP_001172004.1|refseq:NP_001172005.1|refseq:NP_001172010.1|refseq:NP_001172011.1|refseq:NP_002015.1|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990812"(growth cone filopodium)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q06787|rcsb pdb:2BKD|rcsb pdb:2FMR|rcsb pdb:2LA5|rcsb pdb:2QND|rcsb pdb:4OVA|rcsb pdb:4QVZ|rcsb pdb:4QW2|rcsb pdb:5DE5|rcsb pdb:5DE8|rcsb pdb:5DEA|rcsb pdb:5UWJ|rcsb pdb:5UWO|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032196|interpro:IPR036612|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|dip:DIP-29509N	ensembl:ENST00000307546(transcript)|go:"GO:0004385"(guanylate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|ensembl:ENSG00000081026(gene)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0030054"(cell junction)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0016020"(membrane)|go:"GO:0060090"(molecular adaptor activity)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR020590|interpro:IPR027417|interpro:IPR030035|interpro:IPR036020|interpro:IPR036034|mint:Q5TCQ9|rcsb pdb:3SOE|refseq:NP_001136254.1|refseq:NP_690864.2|refseq:XP_005270794.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:+iN/J/MbxTcRwgDezYseEDwLep49606	rogid:muK+zH3ww4Ve8aJ74iU2be8hRa09606	rigid:NUNNpkGzEu84ohw7nZNkDOVg+qM	false	sufficient binding region:280-431	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q06787	uniprotkb:Q8N163	intact:EBI-366305|ensembl:ENSP00000359506|uniprotkb:Q5PQZ6|uniprotkb:Q16578|uniprotkb:Q99054|uniprotkb:A6NNH4|uniprotkb:D3DWT0|uniprotkb:D3DWT1|uniprotkb:D3DWT2|uniprotkb:G8JL90	intact:EBI-355410|uniprotkb:A6NL03|uniprotkb:Q6P0Q9|uniprotkb:Q8N3G7|uniprotkb:Q8N8M1|uniprotkb:Q8TF34|uniprotkb:Q9H9Q9|uniprotkb:Q9HD12|uniprotkb:Q9NT55|ensembl:ENSP00000310670|ensembl:ENSP00000373930|uniprotkb:B2RB79|uniprotkb:D3DSR6	psi-mi:fmr1_human(display_long)|uniprotkb:FMR1(gene name)|psi-mi:FMR1(display_short)|uniprotkb:Fragile X mental retardation protein 1(gene name synonym)	psi-mi:ccar2_human(display_long)|uniprotkb:CCAR2(gene name)|psi-mi:CCAR2(display_short)|uniprotkb:Cell division cycle and apoptosis regulator protein 2(gene name synonym)|uniprotkb:DBC1(gene name synonym)|uniprotkb:DBIRD complex subunit KIAA1967(gene name synonym)|uniprotkb:Deleted in breast cancer gene 1 protein(gene name synonym)|uniprotkb:KIAA1967(gene name synonym)|uniprotkb:p30 DBC(gene name synonym)|uniprotkb:NET35(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509605|imex:IM-28561-1065	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000102081(gene)|ensembl:ENST00000370475(transcript)|refseq:NP_001172004.1|refseq:NP_001172005.1|refseq:NP_001172010.1|refseq:NP_001172011.1|refseq:NP_002015.1|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990812"(growth cone filopodium)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q06787|rcsb pdb:2BKD|rcsb pdb:2FMR|rcsb pdb:2LA5|rcsb pdb:2QND|rcsb pdb:4OVA|rcsb pdb:4QVZ|rcsb pdb:4QW2|rcsb pdb:5DE5|rcsb pdb:5DE8|rcsb pdb:5DEA|rcsb pdb:5UWJ|rcsb pdb:5UWO|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032196|interpro:IPR036612|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|dip:DIP-29509N	refseq:NP_066997.3|ensembl:ENSG00000158941(gene)|ensembl:ENST00000308511(transcript)|ensembl:ENST00000389279(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005819"(spindle)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0008380"(RNA splicing)|go:"GO:0009411"(response to UV)|go:"GO:0016055"(Wnt signaling pathway)|interpro:IPR028811|mint:Q8N163|reactome:R-HSA-3371453|go:"GO:0019899"(enzyme binding)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032784"(regulation of DNA-templated transcription, elongation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0044609"(DBIRD complex)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048511"(rhythmic process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090311"(regulation of protein deacetylation)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:2000003"(positive regulation of DNA damage checkpoint)|interpro:IPR011992(EF-Hand type)|interpro:IPR025223|interpro:IPR025224|interpro:IPR025954|dip:DIP-38122N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:+iN/J/MbxTcRwgDezYseEDwLep49606	rogid:GL+fD8W0kadrYrBkuMqoKgbbITU9606	rigid:5H2h07jQiAkB07m07xn9EaAO/2k	false	sufficient binding region:280-431	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q06787	uniprotkb:Q9NSC5	intact:EBI-366305|ensembl:ENSP00000359506|uniprotkb:Q5PQZ6|uniprotkb:Q16578|uniprotkb:Q99054|uniprotkb:A6NNH4|uniprotkb:D3DWT0|uniprotkb:D3DWT1|uniprotkb:D3DWT2|uniprotkb:G8JL90	intact:EBI-748420|uniprotkb:O14580|uniprotkb:O95350|uniprotkb:Q9NSB9|uniprotkb:Q9NSC0|intact:EBI-2557809|uniprotkb:E9PCW9|uniprotkb:Q9NSC1|intact:EBI-28972925|ensembl:ENSP00000376162|ensembl:ENSP00000439937|ensembl:ENSP00000446026|intact:EBI-10175777|uniprotkb:B2RA10	psi-mi:fmr1_human(display_long)|uniprotkb:FMR1(gene name)|psi-mi:FMR1(display_short)|uniprotkb:Fragile X mental retardation protein 1(gene name synonym)	psi-mi:home3_human(display_long)|uniprotkb:HOMER3(gene name)|psi-mi:HOMER3(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509596|imex:IM-28561-629	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000102081(gene)|ensembl:ENST00000370475(transcript)|refseq:NP_001172004.1|refseq:NP_001172005.1|refseq:NP_001172010.1|refseq:NP_001172011.1|refseq:NP_002015.1|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990812"(growth cone filopodium)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q06787|rcsb pdb:2BKD|rcsb pdb:2FMR|rcsb pdb:2LA5|rcsb pdb:2QND|rcsb pdb:4OVA|rcsb pdb:4QVZ|rcsb pdb:4QW2|rcsb pdb:5DE5|rcsb pdb:5DE8|rcsb pdb:5DEA|rcsb pdb:5UWJ|rcsb pdb:5UWO|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032196|interpro:IPR036612|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|dip:DIP-29509N	ensembl:ENST00000221222|ensembl:ENSP00000221222|ensembl:ENSP00000376162|ensembl:ENST00000433218|ensembl:ENSP00000396154|ensembl:ENSP00000439937|ensembl:ENSP00000446026|ensembl:ENST00000594439|ensembl:ENSP00000471835|refseq:XP_006723006.1|refseq:XP_006723007.1|refseq:NP_001139193.1|refseq:NP_001139194.1|refseq:NP_004829.3|refseq:NP_001139196.1|ensembl:ENSG00000051128(gene)|ensembl:ENST00000392351(transcript)|ensembl:ENST00000539827(transcript)|ensembl:ENST00000542541(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006605"(protein targeting)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030425"(dendrite)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0035256"(G protein-coupled glutamate receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:2001256"(regulation of store-operated calcium entry)|interpro:IPR000697(EVH1)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR044100|mint:Q9NSC5|rcsb pdb:2P8V|rcsb pdb:3CVF|reactome:R-HSA-6794361	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:+iN/J/MbxTcRwgDezYseEDwLep49606	rogid:U1y/y52nnf7zQUCNQlqk7JDgXi49606	rigid:/KLjz/Sw+l58y7j3X/cvTC/tipk	false	sufficient binding region:280-431	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q06787	uniprotkb:Q9C0E4	intact:EBI-366305|ensembl:ENSP00000359506|uniprotkb:Q5PQZ6|uniprotkb:Q16578|uniprotkb:Q99054|uniprotkb:A6NNH4|uniprotkb:D3DWT0|uniprotkb:D3DWT1|uniprotkb:D3DWT2|uniprotkb:G8JL90	intact:EBI-949557|ensembl:ENSP00000478352|uniprotkb:Q8TEH9|uniprotkb:Q9H7H3|uniprotkb:A0A087WU38	psi-mi:fmr1_human(display_long)|uniprotkb:FMR1(gene name)|psi-mi:FMR1(display_short)|uniprotkb:Fragile X mental retardation protein 1(gene name synonym)	psi-mi:grip2_human(display_long)|uniprotkb:GRIP2(gene name)|psi-mi:GRIP2(display_short)|uniprotkb:KIAA1719(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509587|imex:IM-28561-1307	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000102081(gene)|ensembl:ENST00000370475(transcript)|refseq:NP_001172004.1|refseq:NP_001172005.1|refseq:NP_001172010.1|refseq:NP_001172011.1|refseq:NP_002015.1|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990812"(growth cone filopodium)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q06787|rcsb pdb:2BKD|rcsb pdb:2FMR|rcsb pdb:2LA5|rcsb pdb:2QND|rcsb pdb:4OVA|rcsb pdb:4QVZ|rcsb pdb:4QW2|rcsb pdb:5DE5|rcsb pdb:5DE8|rcsb pdb:5DEA|rcsb pdb:5UWJ|rcsb pdb:5UWO|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032196|interpro:IPR036612|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|dip:DIP-29509N	refseq:NP_001073892.3|ensembl:ENSG00000144596(gene)|ensembl:ENST00000621039(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030425"(dendrite)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR030029|interpro:IPR036034|interpro:IPR041489|interpro:IPR043545|mint:Q9C0E4|rcsb pdb:1V62|rcsb pdb:1X5R|reactome:R-HSA-416993	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:+iN/J/MbxTcRwgDezYseEDwLep49606	rogid:lTPxa2HShPc1AvYjV76GCgEl1QA9606	rigid:a9yVIp8CffP2832m0IrJ6RJZnAs	false	sufficient binding region:280-431	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q06787	uniprotkb:P51116	intact:EBI-366305|ensembl:ENSP00000359506|uniprotkb:Q5PQZ6|uniprotkb:Q16578|uniprotkb:Q99054|uniprotkb:A6NNH4|uniprotkb:D3DWT0|uniprotkb:D3DWT1|uniprotkb:D3DWT2|uniprotkb:G8JL90	intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113	psi-mi:fmr1_human(display_long)|uniprotkb:FMR1(gene name)|psi-mi:FMR1(display_short)|uniprotkb:Fragile X mental retardation protein 1(gene name synonym)	psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509578|imex:IM-28561-1305	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000102081(gene)|ensembl:ENST00000370475(transcript)|refseq:NP_001172004.1|refseq:NP_001172005.1|refseq:NP_001172010.1|refseq:NP_001172011.1|refseq:NP_002015.1|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990812"(growth cone filopodium)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q06787|rcsb pdb:2BKD|rcsb pdb:2FMR|rcsb pdb:2LA5|rcsb pdb:2QND|rcsb pdb:4OVA|rcsb pdb:4QVZ|rcsb pdb:4QW2|rcsb pdb:5DE5|rcsb pdb:5DE8|rcsb pdb:5DEA|rcsb pdb:5UWJ|rcsb pdb:5UWO|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032196|interpro:IPR036612|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|dip:DIP-29509N	interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:+iN/J/MbxTcRwgDezYseEDwLep49606	rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606	rigid:08WFi5MjwOSklVFKf7u6GVmWX+w	false	sufficient binding region:280-431	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q06787	uniprotkb:P51114	intact:EBI-366305|ensembl:ENSP00000359506|uniprotkb:Q5PQZ6|uniprotkb:Q16578|uniprotkb:Q99054|uniprotkb:A6NNH4|uniprotkb:D3DWT0|uniprotkb:D3DWT1|uniprotkb:D3DWT2|uniprotkb:G8JL90	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	psi-mi:fmr1_human(display_long)|uniprotkb:FMR1(gene name)|psi-mi:FMR1(display_short)|uniprotkb:Fragile X mental retardation protein 1(gene name synonym)	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509569|imex:IM-28561-1303	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000102081(gene)|ensembl:ENST00000370475(transcript)|refseq:NP_001172004.1|refseq:NP_001172005.1|refseq:NP_001172010.1|refseq:NP_001172011.1|refseq:NP_002015.1|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990812"(growth cone filopodium)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q06787|rcsb pdb:2BKD|rcsb pdb:2FMR|rcsb pdb:2LA5|rcsb pdb:2QND|rcsb pdb:4OVA|rcsb pdb:4QVZ|rcsb pdb:4QW2|rcsb pdb:5DE5|rcsb pdb:5DE8|rcsb pdb:5DEA|rcsb pdb:5UWJ|rcsb pdb:5UWO|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032196|interpro:IPR036612|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|dip:DIP-29509N	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:+iN/J/MbxTcRwgDezYseEDwLep49606	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rigid:XZu8Bcn2D/OvZLbv1jDn+wZ4e2s	false	sufficient binding region:280-431,1-216	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q06787	uniprotkb:Q16760	intact:EBI-366305|ensembl:ENSP00000359506|uniprotkb:Q5PQZ6|uniprotkb:Q16578|uniprotkb:Q99054|uniprotkb:A6NNH4|uniprotkb:D3DWT0|uniprotkb:D3DWT1|uniprotkb:D3DWT2|uniprotkb:G8JL90	intact:EBI-719333|uniprotkb:Q14158|uniprotkb:Q6PK55|uniprotkb:Q8NG53|ensembl:ENSP00000264057|ensembl:ENSP00000487220	psi-mi:fmr1_human(display_long)|uniprotkb:FMR1(gene name)|psi-mi:FMR1(display_short)|uniprotkb:Fragile X mental retardation protein 1(gene name synonym)	psi-mi:dgkd_human(display_long)|uniprotkb:Diglyceride kinase delta(gene name synonym)|uniprotkb:130 kDa diacylglycerol kinase(gene name synonym)|uniprotkb:DGKD(gene name)|psi-mi:DGKD(display_short)|uniprotkb:KIAA0145(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509560|imex:IM-28561-191	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000102081(gene)|ensembl:ENST00000370475(transcript)|refseq:NP_001172004.1|refseq:NP_001172005.1|refseq:NP_001172010.1|refseq:NP_001172011.1|refseq:NP_002015.1|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990812"(growth cone filopodium)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q06787|rcsb pdb:2BKD|rcsb pdb:2FMR|rcsb pdb:2LA5|rcsb pdb:2QND|rcsb pdb:4OVA|rcsb pdb:4QVZ|rcsb pdb:4QW2|rcsb pdb:5DE5|rcsb pdb:5DE8|rcsb pdb:5DEA|rcsb pdb:5UWJ|rcsb pdb:5UWO|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032196|interpro:IPR036612|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|dip:DIP-29509N	refseq:NP_003639.2|refseq:NP_690618.2|ensembl:ENSG00000077044(gene)|ensembl:ENSG00000280873(gene)|ensembl:ENST00000264057(transcript)|ensembl:ENST00000628356(transcript)|go:"GO:0003951"(NAD+ kinase activity)|go:"GO:0004143"(diacylglycerol kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006654"(phosphatidic acid biosynthetic process)|go:"GO:0006897"(endocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007275"(multicellular organism development)|go:"GO:0010033"(response to organic substance)|go:"GO:0015031"(protein transport)|go:"GO:0019900"(kinase binding)|go:"GO:0019932"(second-messenger-mediated signaling)|go:"GO:0019992"(diacylglycerol binding)|go:"GO:0030168"(platelet activation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046339"(diacylglycerol metabolic process)|go:"GO:0046834"(lipid phosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0090038"(negative regulation of protein kinase C signaling)|go:"GO:2000370"(positive regulation of clathrin-dependent endocytosis)|interpro:IPR000756(Diacylglycerol kinase accessory region)|interpro:IPR001206(Diacylglycerol kinase, catalytic region)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR016064(ATP-NAD kinase, PpnK-type)|interpro:IPR017438(ATP-NAD kinase, PpnK-type, alpha/beta)|interpro:IPR037606|interpro:IPR037607|mint:Q16760|rcsb pdb:1R79|rcsb pdb:3BQ7|reactome:R-HSA-114508|dip:DIP-29646N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:+iN/J/MbxTcRwgDezYseEDwLep49606	rogid:rMLPKsHWpeF6qbY0eBQcCeFyMo09606	rigid:3ciG5MdAEQccOqntjZ7Ifoztpq4	false	sufficient binding region:210-431	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q06787	uniprotkb:Q9H773	intact:EBI-366305|ensembl:ENSP00000359506|uniprotkb:Q5PQZ6|uniprotkb:Q16578|uniprotkb:Q99054|uniprotkb:A6NNH4|uniprotkb:D3DWT0|uniprotkb:D3DWT1|uniprotkb:D3DWT2|uniprotkb:G8JL90	intact:EBI-723569|intact:EBI-1384169|ensembl:ENSP00000322524	psi-mi:fmr1_human(display_long)|uniprotkb:FMR1(gene name)|psi-mi:FMR1(display_short)|uniprotkb:Fragile X mental retardation protein 1(gene name synonym)	psi-mi:dctp1_human(display_long)|uniprotkb:DCTPP1(gene name)|psi-mi:DCTPP1(display_short)|uniprotkb:RS21C6(gene name synonym)|uniprotkb:CDA03(orf name)|uniprotkb:XTP3TPA(gene name synonym)|uniprotkb:Deoxycytidine-triphosphatase 1(gene name synonym)|uniprotkb:XTP3-transactivated gene A protein(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509551|imex:IM-28561-1769	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000102081(gene)|ensembl:ENST00000370475(transcript)|refseq:NP_001172004.1|refseq:NP_001172005.1|refseq:NP_001172010.1|refseq:NP_001172011.1|refseq:NP_002015.1|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990812"(growth cone filopodium)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q06787|rcsb pdb:2BKD|rcsb pdb:2FMR|rcsb pdb:2LA5|rcsb pdb:2QND|rcsb pdb:4OVA|rcsb pdb:4QVZ|rcsb pdb:4QW2|rcsb pdb:5DE5|rcsb pdb:5DE8|rcsb pdb:5DEA|rcsb pdb:5UWJ|rcsb pdb:5UWO|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032196|interpro:IPR036612|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|dip:DIP-29509N	refseq:NP_077001.1|ensembl:ENST00000319285(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006253"(dCTP catabolic process)|go:"GO:0009143"(nucleoside triphosphate catabolic process)|go:"GO:0032556"(pyrimidine deoxyribonucleotide binding)|go:"GO:0042262"(DNA protection)|go:"GO:0042802"(identical protein binding)|go:"GO:0047429"(nucleoside-triphosphate diphosphatase activity)|go:"GO:0047840"(dCTP diphosphatase activity)|interpro:IPR025984|mint:Q9H773|reactome:R-HSA-499943|ensembl:ENSG00000179958(gene)	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:+iN/J/MbxTcRwgDezYseEDwLep49606	rogid:4EfV2ZU2MgDiFXShthfualZnat09606	rigid:jsB0bgAA3Gmw3PQQoXmrMCUzjhQ	false	sufficient binding region:210-431	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q06787	uniprotkb:Q13554	intact:EBI-366305|ensembl:ENSP00000359506|uniprotkb:Q5PQZ6|uniprotkb:Q16578|uniprotkb:Q99054|uniprotkb:A6NNH4|uniprotkb:D3DWT0|uniprotkb:D3DWT1|uniprotkb:D3DWT2|uniprotkb:G8JL90	intact:EBI-1058722|ensembl:ENSP00000379098|uniprotkb:A4D2K1|uniprotkb:A4D2K2|uniprotkb:Q9UGH9|uniprotkb:Q9UNX0|uniprotkb:Q9UNX7|uniprotkb:O95437|uniprotkb:O95438|uniprotkb:Q9UP00|uniprotkb:Q9Y5N4|uniprotkb:Q9Y6F4|uniprotkb:A4D2K0|uniprotkb:O95599|uniprotkb:Q9UGH7|uniprotkb:Q9UGH8|uniprotkb:A4D2K4|uniprotkb:A4D2K6|uniprotkb:A4D2K3|intact:EBI-1383493|uniprotkb:A4D2K5	psi-mi:fmr1_human(display_long)|uniprotkb:FMR1(gene name)|psi-mi:FMR1(display_short)|uniprotkb:Fragile X mental retardation protein 1(gene name synonym)	psi-mi:kcc2b_human(display_long)|uniprotkb:CAMK2B(gene name)|psi-mi:CAMK2B(display_short)|uniprotkb:CAM2(gene name synonym)|uniprotkb:CAMKB(gene name synonym)|uniprotkb:CAMK2(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509542|imex:IM-28561-1063	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000102081(gene)|ensembl:ENST00000370475(transcript)|refseq:NP_001172004.1|refseq:NP_001172005.1|refseq:NP_001172010.1|refseq:NP_001172011.1|refseq:NP_002015.1|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990812"(growth cone filopodium)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q06787|rcsb pdb:2BKD|rcsb pdb:2FMR|rcsb pdb:2LA5|rcsb pdb:2QND|rcsb pdb:4OVA|rcsb pdb:4QVZ|rcsb pdb:4QW2|rcsb pdb:5DE5|rcsb pdb:5DE8|rcsb pdb:5DEA|rcsb pdb:5UWJ|rcsb pdb:5UWO|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032196|interpro:IPR036612|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|dip:DIP-29509N	ensembl:ENSG00000058404(gene)|ensembl:ENST00000395749(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005954"(calcium- and calmodulin-dependent protein kinase complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014733"(regulation of skeletal muscle adaptation)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|refseq:NP_001211.3|refseq:NP_742075.1|refseq:NP_742076.1|refseq:NP_742077.1|refseq:NP_742078.1|refseq:NP_742079.1|refseq:NP_742080.1|refseq:NP_742081.1|mint:Q13554|rcsb pdb:3BHH|reactome:R-HSA-111932|reactome:R-HSA-3371571|reactome:R-HSA-399719|reactome:R-HSA-438066|reactome:R-HSA-442729|reactome:R-HSA-442982|reactome:R-HSA-5576892|reactome:R-HSA-5578775|reactome:R-HSA-5673000|reactome:R-HSA-5673001|reactome:R-HSA-6802946|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-877300|reactome:R-HSA-9022692|reactome:R-HSA-936837|reactome:R-HSA-9609736|interpro:IPR032710|reactome:R-HSA-9617324|reactome:R-HSA-9620244|reactome:R-HSA-9649948|reactome:R-HSA-9656223|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0051823"(regulation of synapse structural plasticity)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0090129"(positive regulation of synapse maturation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2001222"(regulation of neuron migration)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|refseq:NP_001280099.1|dip:DIP-39770N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:+iN/J/MbxTcRwgDezYseEDwLep49606	rogid:3RDzSxLdoGtWTECo9At60gEZfZY9606	rigid:VjYk4Vrtr2SPQg3d8FuKIN+9HG4	false	sufficient binding region:210-431	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q06787	uniprotkb:Q13137	intact:EBI-366305|ensembl:ENSP00000359506|uniprotkb:Q5PQZ6|uniprotkb:Q16578|uniprotkb:Q99054|uniprotkb:A6NNH4|uniprotkb:D3DWT0|uniprotkb:D3DWT1|uniprotkb:D3DWT2|uniprotkb:G8JL90	intact:EBI-739580|uniprotkb:B4DDC4|uniprotkb:E7ENK0|uniprotkb:Q53FQ5|uniprotkb:Q53HB5|uniprotkb:Q6IBN9|uniprotkb:Q9BTF7|uniprotkb:B2RBT0|ensembl:ENSP00000258947|uniprotkb:B4E0C0|uniprotkb:E7ETP5|uniprotkb:B4DDT4|uniprotkb:B4DP36|uniprotkb:E9PBE5	psi-mi:fmr1_human(display_long)|uniprotkb:FMR1(gene name)|psi-mi:FMR1(display_short)|uniprotkb:Fragile X mental retardation protein 1(gene name synonym)	psi-mi:caco2_human(display_long)|uniprotkb:CALCOCO2(gene name)|psi-mi:CALCOCO2(display_short)|uniprotkb:NDP52(gene name synonym)|uniprotkb:Nuclear domain 10 protein NDP52(gene name synonym)|uniprotkb:Antigen nuclear dot 52 kDa protein(gene name synonym)|uniprotkb:Nuclear dot protein 52(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509533|imex:IM-28561-1525	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000102081(gene)|ensembl:ENST00000370475(transcript)|refseq:NP_001172004.1|refseq:NP_001172005.1|refseq:NP_001172010.1|refseq:NP_001172011.1|refseq:NP_002015.1|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990812"(growth cone filopodium)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q06787|rcsb pdb:2BKD|rcsb pdb:2FMR|rcsb pdb:2LA5|rcsb pdb:2QND|rcsb pdb:4OVA|rcsb pdb:4QVZ|rcsb pdb:4QW2|rcsb pdb:5DE5|rcsb pdb:5DE8|rcsb pdb:5DEA|rcsb pdb:5UWJ|rcsb pdb:5UWO|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032196|interpro:IPR036612|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|dip:DIP-29509N	refseq:NP_001248319.1|refseq:NP_001248320.1|refseq:NP_001248322.1|refseq:NP_005822.1|ensembl:ENSG00000136436(gene)|ensembl:ENST00000258947(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016032"(viral process)|go:"GO:0016605"(PML body)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0098792"(xenophagy)|go:"GO:1901098"(positive regulation of autophagosome maturation)|interpro:IPR041611|interpro:IPR041641|mint:Q13137|rcsb pdb:2MXP|rcsb pdb:3VVV|rcsb pdb:3VVW|rcsb pdb:4GXL|rcsb pdb:4HAN|rcsb pdb:4XKL|rcsb pdb:5AAQ|rcsb pdb:5Z7A|rcsb pdb:5Z7L|refseq:NP_001248324.1|dip:DIP-57534N	-	-	crc64:609B121DA1A9DCB8	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:+iN/J/MbxTcRwgDezYseEDwLep49606	rogid:N/GPJUGBK+Dh5Cg+csmafphuo9M9606	rigid:mqU1Q7eRo5KHy5xoAV45ztzUApA	false	sufficient binding region:210-431	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q06787	uniprotkb:Q9NWD9	intact:EBI-366305|ensembl:ENSP00000359506|uniprotkb:Q5PQZ6|uniprotkb:Q16578|uniprotkb:Q99054|uniprotkb:A6NNH4|uniprotkb:D3DWT0|uniprotkb:D3DWT1|uniprotkb:D3DWT2|uniprotkb:G8JL90	intact:EBI-15105944|ensembl:ENSP00000361776|ensembl:ENSP00000361780	psi-mi:fmr1_human(display_long)|uniprotkb:FMR1(gene name)|psi-mi:FMR1(display_short)|uniprotkb:Fragile X mental retardation protein 1(gene name synonym)	psi-mi:bex4_human(display_long)|uniprotkb:BEX4(gene name)|psi-mi:BEX4(display_short)|uniprotkb:BEXL1(gene name synonym)|uniprotkb:NADE3(gene name synonym)|uniprotkb:BEX1-like protein 1(gene name synonym)|uniprotkb:Brain-expressed X-linked protein 4(gene name synonym)|uniprotkb:Nerve growth factor receptor-associated protein 3(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509524|imex:IM-28561-627	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000102081(gene)|ensembl:ENST00000370475(transcript)|refseq:NP_001172004.1|refseq:NP_001172005.1|refseq:NP_001172010.1|refseq:NP_001172011.1|refseq:NP_002015.1|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990812"(growth cone filopodium)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q06787|rcsb pdb:2BKD|rcsb pdb:2FMR|rcsb pdb:2LA5|rcsb pdb:2QND|rcsb pdb:4OVA|rcsb pdb:4QVZ|rcsb pdb:4QW2|rcsb pdb:5DE5|rcsb pdb:5DE8|rcsb pdb:5DEA|rcsb pdb:5UWJ|rcsb pdb:5UWO|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032196|interpro:IPR036612|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|dip:DIP-29509N	ensembl:ENSG00000102409(gene)|ensembl:ENST00000372691(transcript)|ensembl:ENST00000372695(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007059"(chromosome segregation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:1904428"(negative regulation of tubulin deacetylation)|interpro:IPR007623(Brain expressed X-linked like protein)|interpro:IPR021156|mint:Q9NWD9|refseq:NP_001073894.1|refseq:NP_001121160.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:+iN/J/MbxTcRwgDezYseEDwLep49606	rogid:BukcZnGYeflhHescSLvqrvZMPHo9606	rigid:sW7QOqH16c+cHtnZBbZPSFZ8ujM	false	sufficient binding region:210-431	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q15019	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-741220|intact:EBI-28986019|ensembl:ENSP00000353157|ensembl:ENSP00000375832|ensembl:ENSP00000375834|ensembl:ENSP00000385172|uniprotkb:Q14132|uniprotkb:Q8IUK9|uniprotkb:Q96CB0|uniprotkb:B4DGE8|uniprotkb:Q53QU3	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:sept2_human(display_long)|uniprotkb:SEPTIN2(gene name)|psi-mi:SEPTIN2(display_short)|uniprotkb:DIFF6(gene name synonym)|uniprotkb:KIAA0158(gene name synonym)|uniprotkb:NEDD5(gene name synonym)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 5(gene name synonym)|uniprotkb:SEPT2(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509747|imex:IM-28561-1775	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_001269901.1|refseq:NP_001269902.1|ensembl:ENSG00000168385(gene)|ensembl:ENST00000360051(transcript)|ensembl:ENST00000391971(transcript)|ensembl:ENST00000391973(transcript)|ensembl:ENST00000402092(transcript)|go:"GO:0000145"(exocyst)|go:"GO:0000776"(kinetochore)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005886"(plasma membrane)|go:"GO:0005930"(axoneme)|go:"GO:0005940"(septin ring)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0030496"(midbody)|go:"GO:0031105"(septin complex)|go:"GO:0031175"(neuron projection development)|go:"GO:0032153"(cell division site)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042802"(identical protein binding)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045296"(cadherin binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061640"(cytoskeleton-dependent cytokinesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097227"(sperm annulus)|go:"GO:0097730"(non-motile cilium)|interpro:IPR008113(Septin 2)|interpro:IPR016491(Septin)|interpro:IPR027417|interpro:IPR030379|mint:Q15019|rcsb pdb:2QA5|rcsb pdb:2QAG|rcsb pdb:2QNR|rcsb pdb:6UPA|rcsb pdb:6UPQ|rcsb pdb:6UPR|reactome:R-HSA-5620912|refseq:NP_001008491.1|refseq:NP_001008492.1|refseq:NP_004395.1|refseq:NP_006146.1|refseq:XP_016859694.1|refseq:XP_016859695.1|refseq:NP_001307958.1|refseq:NP_001307959.1|refseq:NP_001307960.1|refseq:NP_001307961.1|refseq:NP_001307962.1|refseq:NP_001307963.1|refseq:NP_001307964.1|ensembl:ENSP00000353157|ensembl:ENSP00000375832|ensembl:ENSP00000375834|ensembl:ENST00000401990|ensembl:ENSP00000385109|ensembl:ENSP00000385172|ensembl:ENST00000616972|ensembl:ENSP00000479861|dip:DIP-38220N	-	-	crc64:12CCBBE30806F92F	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:H0Us8GtPe2XuXlOYXC0DX79kB/49606	rigid:P/czA96l9QibIu9culgFxcsmqpM	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:O00154	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-948905|ensembl:ENSP00000367086|uniprotkb:O43703|uniprotkb:Q53Y78|uniprotkb:Q5JYL2|uniprotkb:Q5JYL3|uniprotkb:Q5JYL4|uniprotkb:Q5JYL5|uniprotkb:Q5JYL6|uniprotkb:Q5TGR4|uniprotkb:Q9UJM9|uniprotkb:Q9Y539|uniprotkb:Q9Y540|uniprotkb:A8K0K7|uniprotkb:A8K232|uniprotkb:A8K6B8|uniprotkb:A8K837|uniprotkb:B3KQ12	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:bach_human(display_long)|uniprotkb:Long chain acyl-CoA thioester hydrolase(gene name synonym)|uniprotkb:Acyl-CoA thioesterase 7(gene name synonym)|uniprotkb:CTE-IIa(gene name synonym)|uniprotkb:Brain acyl-CoA hydrolase(gene name synonym)|uniprotkb:BACH(gene name synonym)|uniprotkb:ACOT7(gene name)|psi-mi:ACOT7(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509788|imex:IM-28561-653	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	go:"GO:0051792"(medium-chain fatty acid biosynthetic process)|go:"GO:0052689"(carboxylic ester hydrolase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0102991"(myristoyl-CoA hydrolase activity)|go:"GO:1900535"(palmitic acid biosynthetic process)|interpro:IPR006683(Thioesterase superfamily)|interpro:IPR029069|interpro:IPR033120|interpro:IPR040170|mint:O00154|rcsb pdb:2QQ2|reactome:R-HSA-77289|go:"GO:0047617"(acyl-CoA hydrolase activity)|ensembl:ENSG00000097021(gene)|ensembl:ENST00000377855(transcript)|go:"GO:0000062"(fatty-acyl-CoA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006637"(acyl-CoA metabolic process)|go:"GO:0015937"(coenzyme A biosynthetic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0036042"(long-chain fatty acyl-CoA binding)|go:"GO:0036114"(medium-chain fatty-acyl-CoA catabolic process)|go:"GO:0036116"(long-chain fatty-acyl-CoA catabolic process)|go:"GO:0042803"(protein homodimerization activity)|refseq:NP_863655.1|refseq:NP_863656.1|refseq:NP_009205.3|refseq:NP_863654.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:Tv8nHSqfXMmzZqj71+Gec6+29/s9606	rigid:ggYu/cp2iTfMZCBrbg6JMm7Sm5Y	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:P53396	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-1042794|uniprotkb:Q13037|uniprotkb:Q9BRL0|uniprotkb:B4E3P0|uniprotkb:B4DIM0|ensembl:ENSP00000253792|ensembl:ENSP00000466259	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:acly_human(display_long)|uniprotkb:ACLY(gene name)|psi-mi:ACLY(display_short)|uniprotkb:"ATP-citrate (pro-S-)-lyase"(gene name synonym)|uniprotkb:Citrate cleavage enzyme(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509779|imex:IM-28561-383	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_001087.2|refseq:NP_942127.1|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002020(Citrate synthase-like)|interpro:IPR003781(CoA-binding)|interpro:IPR005811(ATP-citrate lyase/succinyl-CoA ligase)|interpro:IPR014608(ATP-citrate synthase)|ensembl:ENSG00000131473(gene)|ensembl:ENST00000352035(transcript)|ensembl:ENST00000590151(transcript)|go:"GO:0003878"(ATP citrate synthase activity)|interpro:IPR016102(Succinyl-CoA synthetase-like)|go:"GO:0005524"(ATP binding)|interpro:IPR016143(Citrate synthase-like, small alpha subdomain)|interpro:IPR017440(ATP-citrate lyase/succinyl-CoA ligase, active site)|interpro:IPR017866|interpro:IPR032263|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006085"(acetyl-CoA biosynthetic process)|go:"GO:0006101"(citrate metabolic process)|go:"GO:0006107"(oxaloacetate metabolic process)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0008610"(lipid biosynthetic process)|go:"GO:0015936"(coenzyme A metabolic process)|go:"GO:0016020"(membrane)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0046872"(metal ion binding)|interpro:IPR033847|rcsb pdb:6O0H|interpro:IPR036291|rcsb pdb:6POE|interpro:IPR036969|rcsb pdb:6POF|rcsb pdb:6QFB|mint:P53396|rcsb pdb:6UI9|rcsb pdb:6UIA|rcsb pdb:3MWD|rcsb pdb:6UUW|rcsb pdb:6UUZ|rcsb pdb:6UV5|rcsb pdb:6Z2H|rcsb pdb:7LIW|rcsb pdb:7LJ9|rcsb pdb:7LLA|reactome:R-HSA-163765|rcsb pdb:3MWE|reactome:R-HSA-6798695|reactome:R-HSA-75105|rcsb pdb:3PFF|rcsb pdb:5TDE|rcsb pdb:5TDF|rcsb pdb:5TDM|rcsb pdb:5TDZ|rcsb pdb:5TE1|rcsb pdb:5TEQ|rcsb pdb:5TES|rcsb pdb:5TET|rcsb pdb:6HXH|rcsb pdb:6HXK|rcsb pdb:6HXL|rcsb pdb:6HXM|refseq:XP_005257452.1|refseq:NP_001290203.1|refseq:NP_001290204.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:NaxO5aRi08GTrEV9aIboUdTlpAs9606	rigid:CpjeG7ax0+OQDJ3nN7ZY9gCUqwE	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q14155	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-717515|uniprotkb:B1ALK6|uniprotkb:B1ALK8|uniprotkb:Q3LIA4|uniprotkb:Q5W9H0|uniprotkb:Q6P9G3|uniprotkb:Q6PII2|uniprotkb:Q86W63|uniprotkb:Q8N3M1|ensembl:ENSP00000364893	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:arhg7_human(display_long)|uniprotkb:PAK-interacting exchange factor beta(gene name synonym)|uniprotkb:Beta-Pix(gene name synonym)|uniprotkb:COOL-1(gene name synonym)|uniprotkb:p85(gene name synonym)|uniprotkb:Nbla10314(orf name)|uniprotkb:ARHGEF7(gene name)|psi-mi:ARHGEF7(display_short)|uniprotkb:COOL1(gene name synonym)|uniprotkb:KIAA0142(gene name synonym)|uniprotkb:P85SPR(gene name synonym)|uniprotkb:PAK3BP(gene name synonym)|uniprotkb:PIXB(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509897|imex:IM-28561-1579	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_001307782.1|refseq:NP_663788.1|refseq:NP_001106983.1|refseq:NP_001106984.1|refseq:NP_001106985.1|refseq:NP_001307780.1|refseq:NP_001307783.1|refseq:NP_001317526.1|refseq:NP_001317527.1|ensembl:ENSG00000102606(gene)|ensembl:ENST00000375741(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0007030"(Golgi organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0005925"(focal adhesion)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043005"(neuron projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0098794"(postsynapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1904424"(regulation of GTP binding)|go:"GO:1905833"(negative regulation of microtubule nucleation)|go:"GO:2000394"(positive regulation of lamellipodium morphogenesis)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035789|interpro:IPR035899|interpro:IPR036028|interpro:IPR036872|mint:Q14155|rcsb pdb:1BY1|rcsb pdb:1ZSG|rcsb pdb:2L3G|rcsb pdb:5SXP|reactome:R-HSA-182971|reactome:R-HSA-193648|reactome:R-HSA-3928664|reactome:R-HSA-416482|reactome:R-HSA-8980692|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013406|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-9013424|reactome:R-HSA-9619229|dip:DIP-40794N|refseq:NP_003890.1|refseq:XP_016876313.1|refseq:XP_016876314.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:0I59YglGXcYP7fFKIAWM6uCZY8Q9606	rigid:Ulm8sJhiORT3Sg3r3Aoimpl0/6M	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q7Z5H3	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-3866859|uniprotkb:A0AVP7|uniprotkb:A5YM75|uniprotkb:Q6ZSB0|uniprotkb:B9EGA0|uniprotkb:O00152|uniprotkb:B4DED8|uniprotkb:C9JDM2|ensembl:ENSP00000249601	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:rhg22_human(display_long)|uniprotkb:ARHGAP22(gene name)|psi-mi:ARHGAP22(display_short)|uniprotkb:RHOGAP2(gene name synonym)|uniprotkb:Rho-type GTPase-activating protein 22(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509888|imex:IM-28561-1351	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_001334667.1|refseq:XP_011538306.1|refseq:NP_067049.2|refseq:NP_001242953.1|refseq:NP_001242955.1|refseq:NP_001242954.1|ensembl:ENSP00000249601|ensembl:ENST00000417247|ensembl:ENSP00000410054|ensembl:ENST00000417912|ensembl:ENSP00000412461|ensembl:ENST00000435790|ensembl:ENSP00000416701|ensembl:ENSG00000128805(gene)|ensembl:ENST00000249601(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0030154"(cell differentiation)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099175"(regulation of postsynapse organization)|interpro:IPR000198(RhoGAP)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|mint:Q7Z5H3|reactome:R-HSA-8980692|reactome:R-HSA-9013148|reactome:R-HSA-9013149	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:B6GppfBTWo7eKA5XTxP6oOG56789606	rigid:UzpkT5It+QFdziC4oFg5I7jLXno	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:O95996	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-1053045|uniprotkb:Q05BW4|uniprotkb:Q9UBZ1|uniprotkb:Q9UEM8|uniprotkb:Q9UQJ8|uniprotkb:Q9UQJ9|uniprotkb:Q9Y632|ensembl:ENSP00000233607|ensembl:ENSP00000442954|ensembl:ENSP00000467073	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:apcl_human(display_long)|uniprotkb:Adenomatous polyposis coli protein-like(gene name synonym)|uniprotkb:APC2(gene name)|psi-mi:APC2(display_short)|uniprotkb:APCL(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509879|imex:IM-28561-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_005874.1|ensembl:ENSP00000233607|ensembl:ENSP00000442954|ensembl:ENSP00000467073|ensembl:ENSG00000115266(gene)|ensembl:ENST00000233607(transcript)|ensembl:ENST00000535453(transcript)|ensembl:ENST00000590469(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001708"(cell fate specification)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005884"(actin filament)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007389"(pattern specification process)|go:"GO:0007399"(nervous system development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0030496"(midbody)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR000225(Armadillo)|interpro:IPR009223(APC cysteine-rich)|interpro:IPR009224(SAMP)|interpro:IPR009234(APC basic)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026818|interpro:IPR026831|interpro:IPR026837|interpro:IPR032038|interpro:IPR036149|interpro:IPR041257|mint:O95996|refseq:XP_006722672.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:v1BSNAoDD3R0+lrhI5zsOZvxFjQ9606	rigid:xSxlbYnnHTrKNx1HExkvnEzTk/Y	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q96CW1	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-297683|ensembl:ENSP00000292807|uniprotkb:A6NE12|uniprotkb:P20172|uniprotkb:P53679|uniprotkb:D3DNT1	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:ap2m1_human(display_long)|uniprotkb:Adaptor protein complex AP-2 subunit mu(gene name synonym)|uniprotkb:AP-2 mu chain(gene name synonym)|uniprotkb:AP2M1(gene name)|psi-mi:AP2M1(display_short)|uniprotkb:CLAPM1(gene name synonym)|uniprotkb:KIAA0109(gene name synonym)|uniprotkb:Adaptin-mu2(gene name synonym)|uniprotkb:Plasma membrane adaptor AP-2 50 kDa protein(gene name synonym)|uniprotkb:HA2 50 kDa subunit(gene name synonym)|uniprotkb:Clathrin coat assembly protein AP50(gene name synonym)|uniprotkb:Clathrin coat-associated protein AP50(gene name synonym)|uniprotkb:Clathrin assembly protein complex 2 mu medium chain(gene name synonym)|uniprotkb:Adaptor-related protein complex 2 subunit mu(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509872|imex:IM-28561-877	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	ensembl:ENSG00000161203(gene)|ensembl:ENST00000292807(transcript)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005048"(signal sequence binding)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0034622"|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0006897"(endocytosis)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0008289"(lipid binding)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030122"(AP-2 adaptor complex)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0031623"(receptor internalization)|go:"GO:0097494"(regulation of vesicle size)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|interpro:IPR001392(Clathrin adaptor, mu subunit)|interpro:IPR011012(Longin-like)|interpro:IPR018240|interpro:IPR022775|interpro:IPR028565|interpro:IPR036168|interpro:IPR043512|interpro:IPR043532|mint:Q96CW1|rcsb pdb:1H6E|rcsb pdb:6BNT|rcsb pdb:6URI|reactome:R-HSA-164939|reactome:R-HSA-167590|reactome:R-HSA-177504|reactome:R-HSA-190873|reactome:R-HSA-196025|reactome:R-HSA-2132295|reactome:R-HSA-3928665|reactome:R-HSA-416993|reactome:R-HSA-437239|reactome:R-HSA-5099900|reactome:R-HSA-5140745|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866427|reactome:R-HSA-8964038|reactome:R-HSA-9679191|reactome:R-HSA-182218|refseq:NP_001020376.1|refseq:NP_004059.2|refseq:NP_001298127.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:AyJEJTqzHtIRWEnMGBzLQP3H5lA9606	rigid:EpzpV8MLQ4tGdaXLlMSiqrmGbF8	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q6ZW76	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-949601|intact:EBI-28970593|ensembl:ENSP00000304586|ensembl:ENSP00000480350|uniprotkb:Q8TF25|uniprotkb:B4DWU4|uniprotkb:D3DUE2	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:anks3_human(display_long)|uniprotkb:ANKS3(gene name)|psi-mi:ANKS3(display_short)|uniprotkb:KIAA1977(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509863|imex:IM-28561-667	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	ensembl:ENSP00000304586|ensembl:ENST00000585773|ensembl:ENSP00000465294|ensembl:ENSP00000480350|ensembl:ENSG00000168096(gene)|ensembl:ENST00000304283(transcript)|ensembl:ENST00000614075(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036770|mint:Q6ZW76|rcsb pdb:4NJ8|rcsb pdb:4NL9|refseq:NP_001229858.1|refseq:NP_597707.1|refseq:NP_001295018.1|refseq:XP_011520675.1|refseq:XP_005255176.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:T0+Qmtm0s/DzwZ5m03SW5dYCRzI9606	rigid:Z3QhuaUt9gSCScvumJmG5jtLlY0	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q6AI12	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-2838246|uniprotkb:Q96E32|ensembl:ENSP00000285243	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:anr40_human(display_long)|uniprotkb:ANKRD40(gene name)|psi-mi:ANKRD40(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509854|imex:IM-28561-1109	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_443087.1|ensembl:ENSG00000154945(gene)|ensembl:ENST00000285243(transcript)|interpro:IPR002110(Ankyrin)|interpro:IPR036770|interpro:IPR039195|mint:Q6AI12	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:N90IlLrtlIyntctaIJLemc16yqI9606	rigid:xkray5XLRzA2Pg8P5IDZcsJWbRY	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:P13196	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-3905054|ensembl:ENSP00000309259|ensembl:ENSP00000378416|ensembl:ENSP00000417719|ensembl:ENSP00000418779	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:hem1_human(display_long)|uniprotkb:ALAS1(gene name)|psi-mi:ALAS1(display_short)|uniprotkb:ALAS3(gene name synonym)|uniprotkb:ALASH(gene name synonym)|uniprotkb:5-aminolevulinic acid synthase 1(gene name synonym)|uniprotkb:Delta-ALA synthase 1(gene name synonym)|uniprotkb:Delta-aminolevulinate synthase 1(gene name synonym)|uniprotkb:OK/SW-cl.121(orf name)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509845|imex:IM-28561-665	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_001291372.1|refseq:NP_001291373.1|refseq:NP_000679.1|refseq:NP_954635.1|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0042541"(hemoglobin biosynthetic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0048821"(erythrocyte development)|ensembl:ENSG00000023330(gene)|ensembl:ENST00000310271(transcript)|ensembl:ENST00000394965(transcript)|ensembl:ENST00000469224(transcript)|ensembl:ENST00000484952(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003870"(5-aminolevulinate synthase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|interpro:IPR001917(Aminotransferase, class-II, pyridoxal-phosphate binding site)|interpro:IPR004839(Aminotransferase, class I and II)|interpro:IPR010961(Tetrapyrrole biosynthesis, 5-aminolevulinic acid synthase)|interpro:IPR015118(5-aminolevulinate synthase presequence)|interpro:IPR015421(Pyridoxal phosphate-dependent transferase, major region, subdomain 1)|interpro:IPR015422(Pyridoxal phosphate-dependent transferase, major region, subdomain 2)|interpro:IPR015424(Pyridoxal phosphate-dependent transferase, major region)|mint:P13196|reactome:R-HSA-189451|reactome:R-HSA-1989781|reactome:R-HSA-2151201|go:"GO:0006782"(protoporphyrinogen IX biosynthetic process)	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:HFjJ6zrRF9UYD7LMB6A3CcxcS7c9606	rigid:lw7wV0BzNuFmSGNtdFElga0jO/E	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q08117	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-717810|uniprotkb:Q12808|uniprotkb:Q96TG9|uniprotkb:Q9UDY9|uniprotkb:B2RBL0|uniprotkb:Q14CJ1|ensembl:ENSP00000317537	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:tle5_human(display_long)|uniprotkb:TLE5(gene name)|psi-mi:TLE5(display_short)|uniprotkb:AES(gene name synonym)|uniprotkb:Amino-terminal enhancer of split(gene name synonym)|uniprotkb:GRG(gene name synonym)|uniprotkb:GRG5(gene name synonym)|uniprotkb:Gp130-associated protein GAM(gene name synonym)|uniprotkb:Grg-5(gene name synonym)|uniprotkb:Groucho-related protein 5(gene name synonym)|uniprotkb:Protein ESP1(gene name synonym)|uniprotkb:Protein GRG(gene name synonym)|uniprotkb:TLE family member 5, transcriptional modulator(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509836|imex:IM-28561-1577	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_001121.2|refseq:NP_945320.1|refseq:NP_945321.1|ensembl:ENSG00000104964(gene)|ensembl:ENST00000327141(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001501"(skeletal system development)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0007275"(multicellular organism development)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0040008"(regulation of growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0060761"(negative regulation of response to cytokine stimulus)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000210"(positive regulation of anoikis)|interpro:IPR005617(Groucho/TLE, N-terminal Q-rich region)|interpro:IPR009146(Groucho/transducin-like enhancer)|mint:Q08117|reactome:R-HSA-4641265|go:"GO:0032091"(negative regulation of protein binding)	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:eveYX2Rj6Oz431E8nGcTk4bUNt89606	rigid:29C7mO6hEr/MWWnYpcAj4Rs7/kk	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q6UY14	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-742002|uniprotkb:Q5T5F7|uniprotkb:Q6IPM6|uniprotkb:Q8N643|uniprotkb:Q9HBS6|ensembl:ENSP00000271643|ensembl:ENSP00000358034|uniprotkb:B2RTT0|uniprotkb:F8WAD0	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:atl4_human(display_long)|uniprotkb:Thrombospondin repeat-containing protein 1(gene name synonym)|uniprotkb:ADAMTSL4(gene name)|psi-mi:ADAMTSL4(display_short)|uniprotkb:TSRC1(gene name synonym)|uniprotkb:PP1396(orf name)|uniprotkb:UNQ2803/PRO34012(orf name)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509827|imex:IM-28561-1349	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_061905.2|refseq:NP_079284.2|ensembl:ENSG00000143382(gene)|ensembl:ENST00000271643(transcript)|ensembl:ENST00000369038(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0002064"(epithelial cell development)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005614"(interstitial matrix)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006915"(apoptotic process)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR010294(ADAM-TS Spacer 1)|interpro:IPR010909(PLAC)|interpro:IPR036383|mint:Q6UY14|reactome:R-HSA-5083635|reactome:R-HSA-5173214|go:"GO:0005576"(extracellular region)|refseq:NP_001275536.1|refseq:NP_001275537.1|refseq:XP_011507950.1|refseq:XP_016856995.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:HIXY8OQopS51RVemJo0GTj8V0WQ9606	rigid:6hBgTDpx6WMwhdAcrz60jtijNGs	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:P35609	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-77797|uniprotkb:Q86TF4|ensembl:ENSP00000355537|uniprotkb:Q86TI8|uniprotkb:B1ANE4|intact:EBI-928705|uniprotkb:B2RCS5	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:actn2_human(display_long)|uniprotkb:ACTN2(gene name)|psi-mi:ACTN2(display_short)|uniprotkb:Alpha-actinin skeletal muscle isoform 2(gene name synonym)|uniprotkb:F-actin cross-linking protein(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509818|imex:IM-28561-1347	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_001094.1|ensembl:ENSG00000077522(gene)|ensembl:ENST00000366578(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005925"(focal adhesion)|go:"GO:0006936"(muscle contraction)|go:"GO:0007155"(cell adhesion)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030018"(Z disc)|go:"GO:0030035"(microspike assembly)|go:"GO:0030175"(filopodium)|go:"GO:0030274"(LIM domain binding)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031143"(pseudopodium)|go:"GO:0031432"(titin binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043267"(negative regulation of potassium ion transport)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045214"(sarcomere organization)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051015"(actin filament binding)|go:"GO:0051373"(FATZ binding)|go:"GO:0051695"(actin filament uncapping)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070080"(titin Z domain binding)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086097"(phospholipase C-activating angiotensin-activated signaling pathway)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|go:"GO:2001137"(positive regulation of endocytic recycling)|go:"GO:0030374"(nuclear receptor coactivator activity)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR036872|mint:P35609|rcsb pdb:1H8B|rcsb pdb:1HCI|rcsb pdb:1QUU|rcsb pdb:4D1E|rcsb pdb:5A36|rcsb pdb:5A37|rcsb pdb:5A38|rcsb pdb:5A4B|rcsb pdb:6SWT|rcsb pdb:6TS3|rcsb pdb:7A8T|rcsb pdb:7A8U|reactome:R-HSA-114608|go:"GO:2001259"(positive regulation of cation channel activity)|reactome:R-HSA-373753|reactome:R-HSA-390522|reactome:R-HSA-442982|reactome:R-HSA-5673001|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-9620244|reactome:R-HSA-438066|refseq:NP_001265272.1|refseq:NP_001265273.1|dip:DIP-383N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:9jws8DZxpttkzqPfDxEzORNnwcE9606	rigid:eQQoYRXjQgvAZAevYMLQHZueVL4	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:P12814	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-351710|uniprotkb:Q9BTN1|uniprotkb:Q1HE25|uniprotkb:B7TY16|intact:EBI-3866221|uniprotkb:B3V8S3|uniprotkb:B4DHH3|ensembl:ENSP00000193403	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:actn1_human(display_long)|uniprotkb:ACTN1(gene name)|psi-mi:ACTN1(display_short)|uniprotkb:Alpha-actinin cytoskeletal isoform(gene name synonym)|uniprotkb:Non-muscle alpha-actinin-1(gene name synonym)|uniprotkb:F-actin cross-linking protein(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509811|imex:IM-28561-221	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_001093.1|refseq:NP_001123477.1|refseq:NP_001123476.1|dip:DIP-33184N|ensembl:ENSG00000072110(gene)|ensembl:ENST00000193403(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005916"(fascia adherens)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0017166"(vinculin binding)|go:"GO:0030018"(Z disc)|go:"GO:0030220"(platelet formation)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031143"(pseudopodium)|go:"GO:0036344"(platelet morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0042995"(cell projection)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051271"(negative regulation of cellular component movement)|go:"GO:0051639"(actin filament network formation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099186"(structural constituent of postsynapse)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR018247|interpro:IPR036872|mint:P12814|rcsb pdb:2EYI|rcsb pdb:2EYN|rcsb pdb:2N8Y|rcsb pdb:2N8Z|reactome:R-HSA-114608|reactome:R-HSA-3000170|reactome:R-HSA-373753|reactome:R-HSA-446388|reactome:R-HSA-9013405|reactome:R-HSA-9013418|reactome:R-HSA-9035034	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:guTURyt26f1ort4NAlYyabNc+WE9606	rigid:IeMSi/+6OEf6wAoPtdpvFZ03710	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:P63261	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-351292|uniprotkb:P02571|uniprotkb:P14104|uniprotkb:P99022|uniprotkb:Q5U032|uniprotkb:Q96E67|uniprotkb:A8K7C2|ensembl:ENSP00000505060|ensembl:ENSP00000505193|ensembl:ENSP00000505235|ensembl:ENSP00000506126|ensembl:ENSP00000506201|ensembl:ENSP00000506253|ensembl:ENSP00000458162|ensembl:ENSP00000458435|ensembl:ENSP00000459119|ensembl:ENSP00000459124|ensembl:ENSP00000460464|ensembl:ENSP00000460660|ensembl:ENSP00000461672|ensembl:ENSP00000466346|ensembl:ENSP00000477968	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:actg_human(display_long)|uniprotkb:ACTG1(gene name)|psi-mi:ACTG1(display_short)|uniprotkb:ACTG(gene name synonym)|uniprotkb:Gamma-actin(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509804|imex:IM-28561-219	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_001186883.1|refseq:NP_001605.1|ensembl:ENST00000570382(transcript)|ensembl:ENSG00000184009(gene)|ensembl:ENST00000571721(transcript)|ensembl:ENST00000573283(transcript)|ensembl:ENST00000575087(transcript)|ensembl:ENST00000575659(transcript)|ensembl:ENST00000575842(transcript)|ensembl:ENST00000575994(transcript)|ensembl:ENST00000576544(transcript)|ensembl:ENST00000615544(transcript)|ensembl:ENST00000679480(transcript)|ensembl:ENST00000679778(transcript)|ensembl:ENST00000680227(transcript)|ensembl:ENST00000680727(transcript)|ensembl:ENST00000681052(transcript)|ensembl:ENST00000681842(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0001895"(retina homeostasis)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005522"(profilin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0030016"(myofibril)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0042802"(identical protein binding)|go:"GO:0043296"(apical junction complex)|go:"GO:0044305"(calyx of Held)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0072562"(blood microparticle)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0097433"(dense body)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098973"(structural constituent of postsynaptic actin cytoskeleton)|go:"GO:0120192"(tight junction assembly)|go:"GO:0120220"(basal body patch)|go:"GO:0150111"(regulation of transepithelial transport)|go:"GO:1902396"(protein localization to bicellular tight junction)|interpro:IPR004000(Actin/actin-like)|interpro:IPR004001(Actin, conserved site)|interpro:IPR020902|interpro:IPR043129|mint:P63261|rcsb pdb:5JLH|rcsb pdb:6CXI|rcsb pdb:6CXJ|rcsb pdb:6G2T|rcsb pdb:6V62|rcsb pdb:6V63|rcsb pdb:6WK1|rcsb pdb:6WK2|reactome:R-HSA-1445148|reactome:R-HSA-190873|reactome:R-HSA-196025|reactome:R-HSA-2029482|reactome:R-HSA-3928662|reactome:R-HSA-3928665|reactome:R-HSA-418990|reactome:R-HSA-437239|reactome:R-HSA-4420097|reactome:R-HSA-445095|reactome:R-HSA-446353|reactome:R-HSA-5626467|reactome:R-HSA-5663213|reactome:R-HSA-5663220|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8856828|reactome:R-HSA-9013418|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9662360|reactome:R-HSA-9662361|reactome:R-HSA-9664422	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:B2OOsE06lTfo90H3g8tlmUJQ7cY9606	rigid:13UjEPuROJCX/JwK7mkHCbjMAHM	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:P60709	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-353944|uniprotkb:P02570|uniprotkb:P70514|uniprotkb:P99021|uniprotkb:Q11211|uniprotkb:Q64316|uniprotkb:Q75MN2|uniprotkb:Q96B34|uniprotkb:Q96HG5|ensembl:ENSP00000494269|ensembl:ENSP00000494750|ensembl:ENSP00000495995|ensembl:ENSP00000501862|ensembl:ENSP00000502821	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:actb_human(display_long)|uniprotkb:ACTB(gene name)|psi-mi:ACTB(display_short)|uniprotkb:Beta-actin(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509797|imex:IM-28561-1575	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_001092.1|ensembl:ENSG00000075624(gene)|ensembl:ENST00000493945(transcript)|ensembl:ENST00000642480(transcript)|ensembl:ENST00000646664(transcript)|ensembl:ENST00000674681(transcript)|ensembl:ENST00000675515(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000785"(chromatin)|go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0001895"(retina homeostasis)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007409"(axonogenesis)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0019894"(kinesin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030424"(axon)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030957"(Tat protein binding)|go:"GO:0031982"(vesicle)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043044"|go:"GO:0043296"(apical junction complex)|go:"GO:0044305"(calyx of Held)|go:"GO:0045176"(apical protein localization)|go:"GO:0045202"(synapse)|go:"GO:0048156"(tau protein binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048870"(cell motility)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051621"(regulation of norepinephrine uptake)|go:"GO:0051623"(positive regulation of norepinephrine uptake)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070160"(tight junction)|go:"GO:0070527"(platelet aggregation)|reactome:R-HSA-4420097|go:"GO:0071896"(protein localization to adherens junction)|go:"GO:0072562"(blood microparticle)|go:"GO:0072749"(cellular response to cytochalasin B)|go:"GO:0097433"(dense body)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098973"(structural constituent of postsynaptic actin cytoskeleton)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0150111"(regulation of transepithelial transport)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR004000(Actin/actin-like)|interpro:IPR004001(Actin, conserved site)|interpro:IPR020902|interpro:IPR043129|mint:P60709|rcsb pdb:3BYH|rcsb pdb:3D2U|rcsb pdb:3J82|rcsb pdb:3LUE|rcsb pdb:6ANU|rcsb pdb:6ICT|rcsb pdb:6ICV|rcsb pdb:6LTJ|rcsb pdb:6MBJ|rcsb pdb:6MBK|rcsb pdb:6MBL|rcsb pdb:6NBW|rcsb pdb:6OX0|rcsb pdb:6OX1|rcsb pdb:6OX2|rcsb pdb:6OX3|rcsb pdb:6OX4|rcsb pdb:6OX5|rcsb pdb:6V62|rcsb pdb:6V63|rcsb pdb:6WK1|rcsb pdb:6WK2|rcsb pdb:7AS4|reactome:R-HSA-1445148|reactome:R-HSA-190873|reactome:R-HSA-196025|reactome:R-HSA-2029482|reactome:R-HSA-3214847|reactome:R-HSA-389957|reactome:R-HSA-390450|reactome:R-HSA-3928662|reactome:R-HSA-3928665|reactome:R-HSA-418990|reactome:R-HSA-437239|reactome:R-HSA-446353|reactome:R-HSA-5250924|reactome:R-HSA-5626467|reactome:R-HSA-5663213|reactome:R-HSA-5663220|reactome:R-HSA-5674135|reactome:R-HSA-5689603|reactome:R-HSA-5696394|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8856828|reactome:R-HSA-9035034|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9662360|reactome:R-HSA-9662361|reactome:R-HSA-9664422|reactome:R-HSA-983231|reactome:R-HSA-445095|dip:DIP-29686N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:Hoge1B8Pn56kvbNTpkSLsQuHwRc9606	rigid:zN7kUyQbjcPvcWJohnlDUZBvsFk	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q53HC0	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-719994|uniprotkb:Q9H697|uniprotkb:B3KNQ0|ensembl:ENSP00000238156|ensembl:ENSP00000488830	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:ccd92_human(display_long)|uniprotkb:Limkain beta-2(gene name synonym)|uniprotkb:CCDC92(gene name)|psi-mi:CCDC92(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510124|imex:IM-28561-1359	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_079416.1|ensembl:ENSG00000119242(gene)|ensembl:ENSG00000275035(gene)|ensembl:ENST00000238156(transcript)|ensembl:ENST00000632401(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR033224|interpro:IPR039496|interpro:IPR040370|mint:Q53HC0|refseq:NP_001291886.1|refseq:NP_001291887.1|refseq:NP_001291888.1|refseq:NP_001291889.1|refseq:NP_001291890.1|refseq:XP_005253681.1|refseq:XP_016875473.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:Iu/FzTqEpzn8N5WUTt1OwoKWxyc9606	rigid:9RQcp+rlVd2Vnv6hW2JwoRQI9y0	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:O75794	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-2808248|ensembl:ENSP00000281141|uniprotkb:Q14107|uniprotkb:Q5T0L9|uniprotkb:Q5T0L4|uniprotkb:Q5T0L7|uniprotkb:Q5T0L8|uniprotkb:A8JZZ7|uniprotkb:Q5T0L5	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:cd123_human(display_long)|uniprotkb:CDC123(gene name)|psi-mi:CDC123(display_short)|uniprotkb:C10orf7(gene name synonym)|uniprotkb:D123(gene name synonym)|uniprotkb:HT-1080(gene name synonym)|uniprotkb:PZ32(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510133|imex:IM-28561-433	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:1905143"(eukaryotic translation initiation factor 2 complex assembly)|interpro:IPR009772(D123)|mint:O75794|go:"GO:0045948"(positive regulation of translational initiation)|ensembl:ENSG00000151465(gene)|ensembl:ENST00000281141(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0007049"(cell cycle)|go:"GO:0008284"(positive regulation of cell population proliferation)|refseq:NP_006014.2	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:VMzeYhMYvt77+83yeASAqju49xQ9606	rigid:g+kW7b7mYdko8tJ7Vm4dQKwm+zM	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q6UXH8	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-3923278|uniprotkb:Q8TF19|uniprotkb:Q86SS2|uniprotkb:Q6MZX5|ensembl:ENSP00000404464|ensembl:ENSP00000497183	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:ccbe1_human(display_long)|uniprotkb:CCBE1(gene name)|psi-mi:CCBE1(display_short)|uniprotkb:KIAA1983(gene name synonym)|uniprotkb:Full of fluid protein homolog(gene name synonym)|uniprotkb:UNQ1921/PRO4395(orf name)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510110|imex:IM-28561-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_597716.1|ensembl:ENSG00000183287(gene)|ensembl:ENST00000439986(transcript)|ensembl:ENST00000649564(transcript)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0002020"(protease binding)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0003016"(respiratory system process)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0030324"(lung development)|go:"GO:0031012"(extracellular matrix)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048845"(venous blood vessel morphogenesis)|go:"GO:1900748"(positive regulation of vascular endothelial growth factor signaling pathway)|go:"GO:1901492"(positive regulation of lymphangiogenesis)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR018097|mint:Q6UXH8	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:nehCkrSZQzV0/EXSNswv+xS6PWs9606	rigid:pq+p9RdJ6eC42nep0+gBsq7ij0c	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:P35520	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-740135|uniprotkb:Q99425|uniprotkb:Q9BWC5|uniprotkb:B2R993|uniprotkb:D3DSK4|intact:EBI-14245939|ensembl:ENSP00000344460|ensembl:ENSP00000352643|ensembl:ENSP00000381225|ensembl:ENSP00000381231	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:cbs_human(display_long)|uniprotkb:CBS(gene name)|psi-mi:CBS(display_short)|uniprotkb:Serine sulfhydrase(gene name synonym)|uniprotkb:Beta-thionase(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510101|imex:IM-28561-1113	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_000062.1|refseq:NP_001171479.1|refseq:NP_001171480.1|ensembl:ENSG00000160200(gene)|ensembl:ENST00000352178(transcript)|ensembl:ENST00000359624(transcript)|ensembl:ENST00000398158(transcript)|go:"GO:0004122"(cystathionine beta-synthase activity)|ensembl:ENST00000398165(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006535"(cysteine biosynthetic process from serine)|go:"GO:0006563"(L-serine metabolic process)|go:"GO:0006565"(L-serine catabolic process)|go:"GO:0019343"(cysteine biosynthetic process via cystathionine)|go:"GO:0019344"(cysteine biosynthetic process)|go:"GO:0019346"(transsulfuration)|go:"GO:0019448"(L-cysteine catabolic process)|go:"GO:0019825"(oxygen binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0020037"(heme binding)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042262"(DNA protection)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043418"(homocysteine catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0050421"("nitrite reductase (NO-forming) activity")|go:"GO:0050667"(homocysteine metabolic process)|go:"GO:0070025"(carbon monoxide binding)|go:"GO:0070026"(nitric oxide binding)|go:"GO:0070814"(hydrogen sulfide biosynthetic process)|go:"GO:0072341"(modified amino acid binding)|go:"GO:1904047"(S-adenosyl-L-methionine binding)|interpro:IPR000644(Cystathionine beta-synthase, core)|interpro:IPR001216(Cysteine synthase/cystathionine beta-synthase P-phosphate-binding site)|interpro:IPR001926(Pyridoxal phosphate-dependent enzyme, beta subunit)|interpro:IPR005857(Cystathionine beta-synthase)|interpro:IPR036052|mint:P35520|rcsb pdb:1JBQ|rcsb pdb:1M54|rcsb pdb:4COO|rcsb pdb:4L0D|rcsb pdb:4L27|rcsb pdb:4L28|rcsb pdb:4L3V|rcsb pdb:4PCU|rcsb pdb:4UUU|rcsb pdb:5MMS|reactome:R-HSA-1614603|reactome:R-HSA-2408508|refseq:XP_011528079.1|refseq:XP_011528083.1|refseq:XP_011528084.1|refseq:XP_011544396.1|refseq:XP_011544397.1|refseq:XP_011544399.1|refseq:XP_011544400.1|refseq:XP_011544401.1|refseq:NP_001307227.1|refseq:NP_001308002.1|refseq:XP_016883700.1|refseq:XP_016883701.1|refseq:XP_016883702.1|refseq:XP_016883703.1|refseq:XP_016883704.1|refseq:XP_016883705.1|refseq:XP_016883706.1|refseq:XP_016883707.1|refseq:XP_016883978.1|refseq:XP_016883979.1|refseq:XP_016883980.1|refseq:XP_016883981.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:f9eo0cPOHppVY7Nqejag3YyK18s9606	rigid:uWzzcUPkTiOTmpqbdjfHER8YFBM	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q14444	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-1047080|uniprotkb:Q15074|intact:EBI-1171814|uniprotkb:Q6IMN4|uniprotkb:A6NMY7|uniprotkb:Q6IMN7|uniprotkb:Q9BV09|intact:EBI-2562858|intact:EBI-3449178|uniprotkb:D3DR06|ensembl:ENSP00000340329|ensembl:ENSP00000434150	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:capr1_human(display_long)|uniprotkb:CAPRIN1(gene name)|psi-mi:CAPRIN1(display_short)|uniprotkb:GPIAP1(gene name synonym)|uniprotkb:GPIP137(gene name synonym)|uniprotkb:M11S1(gene name synonym)|uniprotkb:Cytoplasmic activation- and proliferation-associated protein 1(gene name synonym)|uniprotkb:GPI-anchored membrane protein 1(gene name synonym)|uniprotkb:GPI-anchored protein p137(gene name synonym)|uniprotkb:Cell cycle-associated protein 1(gene name synonym)|uniprotkb:Membrane component chromosome 11 surface marker 1(gene name synonym)|uniprotkb:RNG105(gene name synonym)|uniprotkb:RNA granule protein 105(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510094|imex:IM-28561-677	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_005889.3|refseq:NP_976240.1|ensembl:ENSG00000135387(gene)|ensembl:ENST00000341394(transcript)|ensembl:ENST00000532820(transcript)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030027"(lamellipodium)|go:"GO:0030425"(dendrite)|go:"GO:0031252"(cell leading edge)|go:"GO:0045202"(synapse)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|interpro:IPR022070|interpro:IPR028816|interpro:IPR041637|mint:Q14444|rcsb pdb:4WBE|rcsb pdb:4WBP|rcsb pdb:6TA7|refseq:XP_016873238.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:3c6ZdBClP/D6jIi8NfzBkMc61pI9606	rigid:cHe3Bz/ZY3VIL2F/tYnEQQR2yxs	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:P20807	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-5655000|ensembl:ENSP00000380349|uniprotkb:Q9Y5S6|uniprotkb:Q9Y5S7|uniprotkb:Q9BTU4|uniprotkb:A6H8K6|uniprotkb:Q7L4R0|uniprotkb:Q9BQC8	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:can3_human(display_long)|uniprotkb:CANP3(gene name synonym)|uniprotkb:CANPL3(gene name synonym)|uniprotkb:Calcium-activated neutral proteinase 3(gene name synonym)|uniprotkb:Calpain L3(gene name synonym)|uniprotkb:Calpain p94(gene name synonym)|uniprotkb:Muscle-specific calcium-activated neutral protease 3(gene name synonym)|uniprotkb:NCL1(gene name synonym)|uniprotkb:New calpain 1(gene name synonym)|uniprotkb:CAPN3(gene name)|psi-mi:CAPN3(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510085|imex:IM-28561-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	ensembl:ENSG00000092529(gene)|ensembl:ENST00000397163(transcript)|go:"GO:0003824"(catalytic activity)|go:"GO:0004198"(calcium-dependent cysteine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005622"(intracellular anatomical structure)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007517"(muscle organ development)|go:"GO:0008233"(peptidase activity)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0014718"(positive regulation of satellite cell activation involved in skeletal muscle regeneration)|go:"GO:0014850"(response to muscle activity)|go:"GO:0030016"(myofibril)|go:"GO:0030018"(Z disc)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030239"(myofibril assembly)|refseq:NP_000061.1|refseq:NP_077320.1|refseq:NP_775110.1|refseq:NP_775111.1|refseq:NP_775112.1|refseq:NP_775113.1|go:"GO:0030315"(T-tubule)|go:"GO:0031402"(sodium ion binding)|go:"GO:0031432"(titin binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045661"(regulation of myoblast differentiation)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051592"(response to calcium ion)|go:"GO:0055103"(ligase regulator activity)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061061"(muscle structure development)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070315"(G1 to G0 transition involved in cell differentiation)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071472"(cellular response to salt stress)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0097264"(self proteolysis)|go:"GO:1990092"(calcium-dependent self proteolysis)|interpro:IPR000169(Peptidase, cysteine peptidase active site)|interpro:IPR001300(Peptidase C2, calpain)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR022682|interpro:IPR022683|interpro:IPR022684|interpro:IPR029531|interpro:IPR033883|interpro:IPR036213|interpro:IPR038765|mint:P20807|rcsb pdb:1Y9V|rcsb pdb:4OKH|rcsb pdb:6BDT|rcsb pdb:6BGP|rcsb pdb:6BJD|rcsb pdb:6BKJ|reactome:R-HSA-1474228	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:niIxeCH+wcEYovZ1/3/zTO27bOU9606	rigid:PhimIetRw9qXVhZOB39MmWPKums	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q13555	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-1383465|uniprotkb:O00561|uniprotkb:Q5SWX4|uniprotkb:Q8NIA4|uniprotkb:O15378|uniprotkb:Q13556|uniprotkb:Q5SQZ3|uniprotkb:Q5SQZ4|uniprotkb:Q8N4I3|uniprotkb:Q13279|uniprotkb:Q13282|uniprotkb:Q7KYX5|uniprotkb:A0A0A0MS52|uniprotkb:A0A0A0MT11	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:kcc2g_human(display_long)|uniprotkb:CAMK(gene name synonym)|uniprotkb:CAMK-II(gene name synonym)|uniprotkb:CAMK2G(gene name)|psi-mi:CAMK2G(display_short)|uniprotkb:CAMKG(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510076|imex:IM-28561-1587	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_001213.2|refseq:NP_751909.1|refseq:NP_751913.1|refseq:XP_005270260.1|refseq:NP_001307827.1|refseq:NP_001191421.1|dip:DIP-51315N|mint:Q13555|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-877300|reactome:R-HSA-9022692|reactome:R-HSA-936837|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-9620244|reactome:R-HSA-9649948|reactome:R-HSA-9656223|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0004723"(calcium-dependent protein serine/threonine phosphatase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005954"(calcium- and calmodulin-dependent protein kinase complex)|go:"GO:0007399"(nervous system development)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0014733"(regulation of skeletal muscle adaptation)|go:"GO:0016020"(membrane)|go:"GO:0030073"(insulin secretion)|go:"GO:0030154"(cell differentiation)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR032710|rcsb pdb:2UX0|rcsb pdb:2V7O|reactome:R-HSA-111932|reactome:R-HSA-3371571|reactome:R-HSA-399719|reactome:R-HSA-438066|reactome:R-HSA-442729|reactome:R-HSA-442982|reactome:R-HSA-5576892|reactome:R-HSA-5578775|reactome:R-HSA-5673000|reactome:R-HSA-5673001|reactome:R-HSA-6802946	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:qtCEps5UkV7tprB2QmjCDK5YyIo9606	rigid:iRcYQ3G4YTtL41XlZw/q063v7U4	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q13554	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-1058722|ensembl:ENSP00000379098|uniprotkb:A4D2K1|uniprotkb:A4D2K2|uniprotkb:Q9UGH9|uniprotkb:Q9UNX0|uniprotkb:Q9UNX7|uniprotkb:O95437|uniprotkb:O95438|uniprotkb:Q9UP00|uniprotkb:Q9Y5N4|uniprotkb:Q9Y6F4|uniprotkb:A4D2K0|uniprotkb:O95599|uniprotkb:Q9UGH7|uniprotkb:Q9UGH8|uniprotkb:A4D2K4|uniprotkb:A4D2K6|uniprotkb:A4D2K3|intact:EBI-1383493|uniprotkb:A4D2K5	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:kcc2b_human(display_long)|uniprotkb:CAMK2B(gene name)|psi-mi:CAMK2B(display_short)|uniprotkb:CAM2(gene name synonym)|uniprotkb:CAMKB(gene name synonym)|uniprotkb:CAMK2(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510067|imex:IM-28561-675	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	ensembl:ENSG00000058404(gene)|ensembl:ENST00000395749(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005954"(calcium- and calmodulin-dependent protein kinase complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014733"(regulation of skeletal muscle adaptation)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|refseq:NP_001211.3|refseq:NP_742075.1|refseq:NP_742076.1|refseq:NP_742077.1|refseq:NP_742078.1|refseq:NP_742079.1|refseq:NP_742080.1|refseq:NP_742081.1|mint:Q13554|rcsb pdb:3BHH|reactome:R-HSA-111932|reactome:R-HSA-3371571|reactome:R-HSA-399719|reactome:R-HSA-438066|reactome:R-HSA-442729|reactome:R-HSA-442982|reactome:R-HSA-5576892|reactome:R-HSA-5578775|reactome:R-HSA-5673000|reactome:R-HSA-5673001|reactome:R-HSA-6802946|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-877300|reactome:R-HSA-9022692|reactome:R-HSA-936837|reactome:R-HSA-9609736|interpro:IPR032710|reactome:R-HSA-9617324|reactome:R-HSA-9620244|reactome:R-HSA-9649948|reactome:R-HSA-9656223|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0051823"(regulation of synapse structural plasticity)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0090129"(positive regulation of synapse maturation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2001222"(regulation of neuron migration)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|refseq:NP_001280099.1|dip:DIP-39770N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:3RDzSxLdoGtWTECo9At60gEZfZY9606	rigid:jQnm1o3Ue1iQiDCP7oVJDIkkGic	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q9UQM7	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-1383687|uniprotkb:Q9UL21|uniprotkb:Q9Y2H4|uniprotkb:Q9Y352|ensembl:ENSP00000261793|ensembl:ENSP00000500642	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:kcc2a_human(display_long)|uniprotkb:CAMK2A(gene name)|psi-mi:CAMK2A(display_short)|uniprotkb:CAMKA(gene name synonym)|uniprotkb:KIAA0968(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510058|imex:IM-28561-1585	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_741960.1|ensembl:ENSG00000070808(gene)|ensembl:ENST00000348628(transcript)|ensembl:ENST00000672479(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0002931"(response to ischemia)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005954"(calcium- and calmodulin-dependent protein kinase complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0009931"(calcium-dependent protein serine/threonine kinase activity)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038166"(angiotensin-activated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0060996"(dendritic spine development)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902108"(regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1990443"(peptidyl-threonine autophosphorylation)|go:"GO:2000124"(regulation of endocannabinoid signaling pathway)|go:"GO:2001222"(regulation of neuron migration)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR032710|mint:Q9UQM7|rcsb pdb:2VZ6|rcsb pdb:3SOA|rcsb pdb:5IG3|rcsb pdb:6OF8|rcsb pdb:6VZK|rcsb pdb:6W4O|rcsb pdb:6W4P|rcsb pdb:6X5G|rcsb pdb:6X5Q|rcsb pdb:6X8V|rcsb pdb:6XBP|rcsb pdb:6XBX|rcsb pdb:6XDL|rcsb pdb:6XDU|rcsb pdb:6XF0|rcsb pdb:6XOE|rcsb pdb:7KL0|rcsb pdb:7KL1|rcsb pdb:7KL2|rcsb pdb:7KL4|reactome:R-HSA-111932|reactome:R-HSA-3371571|reactome:R-HSA-399719|reactome:R-HSA-4086398|reactome:R-HSA-438066|reactome:R-HSA-442982|reactome:R-HSA-5576892|reactome:R-HSA-5578775|reactome:R-HSA-5673000|reactome:R-HSA-5673001|reactome:R-HSA-6802946|go:"GO:0016301"(kinase activity)|reactome:R-HSA-6802952|reactome:R-HSA-877300|reactome:R-HSA-9022692|reactome:R-HSA-936837|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-9620244|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-6802955|dip:DIP-39705N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:7uql+9kLfmK9drY5L0oKOH7zPk49606	rigid:4DWG9Wxsdwx/6XHX/m2XaPGP+dM	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q9P1Z2	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-749920|uniprotkb:B3KVA8|uniprotkb:Q6FI59|uniprotkb:Q71RC3|uniprotkb:Q86WF8|uniprotkb:Q96JU3|uniprotkb:Q9H090|intact:EBI-2558801|ensembl:ENSP00000449960	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:caco1_human(display_long)|uniprotkb:CALCOCO1(gene name)|psi-mi:CALCOCO1(display_short)|uniprotkb:KIAA1536(gene name synonym)|uniprotkb:Calphoglin(gene name synonym)|uniprotkb:Sarcoma antigen NY-SAR-3(gene name synonym)|uniprotkb:Coiled-coil coactivator protein(gene name synonym)|uniprotkb:PP13275(orf name)|uniprotkb:UNQ2436/PRO4996(orf name)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510051|imex:IM-28561-1357	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_001137154.1|refseq:NP_065949.1|refseq:XP_016875196.1|dip:DIP-47322N|ensembl:ENSG00000012822(gene)|ensembl:ENST00000550804(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0007165"(signal transduction)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030518"(intracellular steroid hormone receptor signaling pathway)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0070016"(armadillo repeat domain binding)|interpro:IPR012852(Coiled-coil transcriptional coactivator-like)|interpro:IPR041611|interpro:IPR041641|mint:Q9P1Z2	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:4M9Qyq+7GZ1w2UAN6k0ntGQNTvw9606	rigid:ILo0+N9tqs5EsUZyS/aKCVU/Li0	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q9NS85	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-21798903|uniprotkb:B2R7J0|uniprotkb:B4DGL6|intact:EBI-28972912|ensembl:ENSP00000285273|ensembl:ENSP00000390666|ensembl:ENSP00000405388	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:cah10_human(display_long)|uniprotkb:Carbonic anhydrase-related protein X(gene name synonym)|uniprotkb:Cerebral protein 15(gene name synonym)|uniprotkb:UNQ533/PRO1076(orf name)|uniprotkb:hucep-15(orf name)|uniprotkb:CA10(gene name)|psi-mi:CA10(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510042|imex:IM-28561-885	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	ensembl:ENSP00000285273|ensembl:ENSP00000390666|ensembl:ENSP00000405388|ensembl:ENST00000570565|ensembl:ENSP00000459619|refseq:NP_001076002.1|refseq:NP_001076003.1|refseq:NP_064563.1|ensembl:ENSG00000154975(gene)|ensembl:ENST00000285273(transcript)|ensembl:ENST00000442502(transcript)|ensembl:ENST00000451037(transcript)|go:"GO:0004089"(carbonate dehydratase activity)|go:"GO:0006730"(one-carbon metabolic process)|go:"GO:0007420"(brain development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016836"(hydro-lyase activity)|interpro:IPR001148(Carbonic anhydrase, eukaryotic)|interpro:IPR018423|interpro:IPR023561|interpro:IPR036398|interpro:IPR041878|mint:Q9NS85	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:cz53+aW3y6Pg+D7UIp/FJ1J9WjE9606	rigid:fdPl2ZNuFHVMwsFdWoYNdJ4Pu9c	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q96H12	uniprotkb:P51114	intact:EBI-8466227|uniprotkb:Q5T728|uniprotkb:Q5T726|uniprotkb:Q5T727|intact:MINT-7032147|uniprotkb:B2RC35|ensembl:ENSP00000378506|ensembl:ENSP00000480445|ensembl:ENSP00000480622	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	psi-mi:msd3_human(display_long)|uniprotkb:MSANTD3(gene name)|psi-mi:MSANTD3(display_short)|uniprotkb:C9orf30(gene name synonym)|uniprotkb:L8(orf name)	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510035|imex:IM-28561-673	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001185735.1|refseq:NP_001185734.1|refseq:NP_542386.1|refseq:NP_001185736.1|ensembl:ENSG00000066697(gene)|ensembl:ENST00000395067(transcript)|ensembl:ENST00000613183(transcript)|ensembl:ENST00000622639(transcript)|interpro:IPR026709|interpro:IPR028002|mint:Q96H12	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	-	comment:mint|comment:homomint	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:JOWl9WQVA131ZH45W9BYNpdEAJU9606	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rigid:0wMTVG7iK3UYa5eUHE8DNoxDLOY	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q9H799	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-2811541|uniprotkb:Q9H5T1|uniprotkb:Q8N8L4|uniprotkb:Q4G174|uniprotkb:Q9H8T9|ensembl:ENSP00000421690|intact:EBI-3261532|uniprotkb:A8MUB7|uniprotkb:B7ZLV7|uniprotkb:Q6DK46	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:cpln1_human(display_long)|uniprotkb:C5orf42(gene name synonym)|uniprotkb:JBTS17(gene name synonym)|uniprotkb:Protein JBTS17(gene name synonym)|uniprotkb:CPLANE1(gene name)|psi-mi:CPLANE1(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510026|imex:IM-28561-1355	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	ensembl:ENSG00000197603(gene)|ensembl:ENST00000508244(transcript)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0060271"(cilium assembly)|interpro:IPR028236|interpro:IPR036322|mint:Q9H799|refseq:NP_075561.3	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:8zhawWxiqpQM34EraNekNaz/N/o9606	rigid:rb59BLz6MCrmZ6XDEHu7cvpEEG4	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q07021	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-347528|uniprotkb:Q2HXR8|uniprotkb:Q9NNY8|intact:EBI-15990352|ensembl:ENSP00000225698	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:c1qbp_human(display_long)|uniprotkb:C1QBP(gene name)|psi-mi:C1QBP(display_short)|uniprotkb:GC1QBP(gene name synonym)|uniprotkb:HABP1(gene name synonym)|uniprotkb:SF2P32(gene name synonym)|uniprotkb:Glycoprotein gC1qBP(gene name synonym)|uniprotkb:Hyaluronan-binding protein 1(gene name synonym)|uniprotkb:Mitochondrial matrix protein p32(gene name synonym)|uniprotkb:p33(gene name synonym)|uniprotkb:ASF/SF2-associated protein p32(gene name synonym)|uniprotkb:gC1q-R protein(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510019|imex:IM-28561-883	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_001203.1|dip:DIP-31164N|ensembl:ENSG00000108561(gene)|ensembl:ENST00000225698(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005540"(hyaluronic acid binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006397"(mRNA processing)|go:"GO:0006915"(apoptotic process)|go:"GO:0006955"(immune response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0008494"(translation activator activity)|go:"GO:0009986"(cell surface)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0030449"(regulation of complement activation)|go:"GO:0030984"(kininogen binding)|go:"GO:0031690"(adrenergic receptor binding)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0039534"(negative regulation of MDA-5 signaling pathway)|go:"GO:0039536"(negative regulation of RIG-I signaling pathway)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0042256"(mature ribosome assembly)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050687"(negative regulation of defense response to virus)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070131"(positive regulation of mitochondrial translation)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0097177"(mitochondrial ribosome binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:2000510"(positive regulation of dendritic cell chemotaxis)|interpro:IPR003428(Mitochondrial glycoprotein)|interpro:IPR036561|mint:Q07021|rcsb pdb:1P32|rcsb pdb:3RPX|rcsb pdb:6SZW|reactome:R-HSA-111471|go:"GO:0005886"(plasma membrane)|reactome:R-HSA-8980692|reactome:R-HSA-9013106|reactome:R-HSA-9645722|reactome:R-HSA-140837	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:NfZ31HjbYZxd8UQKRXczhpc306E9606	rigid:PMBXExdr2KAPwNL7lqSMhwJ16xs	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q8N1I8	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-26510006	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:caas1_human(display_long)|uniprotkb:CACTIN-AS1(gene name)|psi-mi:CACTIN-AS1(display_short)|uniprotkb:C19orf29-AS1(gene name synonym)|uniprotkb:C19orf29OS(gene name synonym)|uniprotkb:Cactin antisense RNA 1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510012|imex:IM-28561-881	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	mint:Q8N1I8	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:X91XahDyab4qIMjdYRsnTuf+Y449606	rigid:iCSxXnyiD2wQCLz19+/owpFpQQ8	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q6ZVL6	uniprotkb:P51114	intact:EBI-2320371|uniprotkb:B0QYU0|ensembl:ENSP00000315295	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	psi-mi:k154l_human(display_long)|uniprotkb:KIAA1549L(gene name)|psi-mi:KIAA1549L(display_short)|uniprotkb:C11orf41(gene name synonym)|uniprotkb:C11orf69(gene name synonym)	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509997|imex:IM-28561-227	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011518271.1|refseq:NP_036326.2|ensembl:ENSG00000110427(gene)|ensembl:ENST00000321505(transcript)|go:"GO:0016021"(integral component of membrane)|interpro:IPR024606|mint:Q6ZVL6	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:ms/4igVx/iJRKbNf2+01PfpIWng9606	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rigid:mgXBm5eGBw/1sytZP+ElooZyQHo	false	-	sufficient binding region:215-363	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q9UID3	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-2932923|ensembl:ENSP00000279281|uniprotkb:Q6PJV5|uniprotkb:Q7L8A6|uniprotkb:Q8WZ35|uniprotkb:Q96DF4|uniprotkb:Q96GR3	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:vps51_human(display_long)|uniprotkb:VPS51(gene name)|psi-mi:VPS51(display_short)|uniprotkb:ANG2(gene name synonym)|uniprotkb:Another new gene 2 protein(gene name synonym)|uniprotkb:C11orf2(gene name synonym)|uniprotkb:C11orf3(gene name synonym)|uniprotkb:FFR(gene name synonym)|uniprotkb:Protein fat-free homolog(gene name synonym)|uniprotkb:PP5382(orf name)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509988|imex:IM-28561-225	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	ensembl:ENSG00000149823(gene)|ensembl:ENST00000279281(transcript)|go:"GO:0000938"(GARP complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006869"(lipid transport)|go:"GO:0006914"(autophagy)|go:"GO:0007030"(Golgi organization)|go:"GO:0007041"(lysosomal transport)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048193"(Golgi vesicle transport)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0055037"(recycling endosome)|go:"GO:1990745"(EARP complex)|interpro:IPR014812(Vps51/Vps67)|interpro:IPR016159(Cullin repeat-like)|mint:Q9UID3|rcsb pdb:4J2C|reactome:R-HSA-6811440|refseq:NP_037397.2|dip:DIP-60562N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:UGjZbNWrm7SCFNgZLmPRor03b+k9606	rigid:oe2ZGoSQAwZXfwAtA8sXwKBetts	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q5VWN6	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-745958|uniprotkb:Q2YD91|uniprotkb:Q5VWN5|uniprotkb:Q6ZRQ8|uniprotkb:Q8IVG4|uniprotkb:Q9BUZ7|uniprotkb:Q9H5J9|uniprotkb:Q9H7A4|uniprotkb:Q9H996|uniprotkb:Q9NXA1|intact:EBI-28974916|ensembl:ENSP00000328426	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:taso2_human(display_long)|uniprotkb:TASOR2(gene name)|psi-mi:TASOR2(display_short)|uniprotkb:C10orf18(gene name synonym)|uniprotkb:FAM208B(gene name synonym)|uniprotkb:KIAA2006(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509979|imex:IM-28561-431	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_060252.4|ensembl:ENSP00000328426|refseq:XP_011517827.1|refseq:XP_016871852.1|refseq:XP_016871854.1|ensembl:ENSG00000108021(gene)|ensembl:ENST00000328090(transcript)|go:"GO:0005829"(cytosol)|interpro:IPR022168|interpro:IPR022188|mint:Q5VWN6|go:"GO:0005654"(nucleoplasm)|refseq:XP_005252532.1|refseq:XP_005252537.1|refseq:XP_005252538.1|refseq:XP_005252539.1|refseq:NP_001308712.1|refseq:NP_001308713.1|refseq:NP_001308714.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:mTRMzWB45dZojaB1ZrsaQRT48YQ9606	rigid:WVP9oACaiHv33C0uke0PVkMe8MM	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q96KE9	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-3937311|uniprotkb:Q9BR94|uniprotkb:Q8IVQ7|ensembl:ENSP00000443091	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:btbd6_human(display_long)|uniprotkb:BTBD6(gene name)|psi-mi:BTBD6(display_short)|uniprotkb:BDPL(gene name synonym)|uniprotkb:Lens BTB domain protein(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509970|imex:IM-28561-671	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	ensembl:ENSG00000184887(gene)|ensembl:ENST00000536364(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0022008"(neurogenesis)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR012983(PHR)|interpro:IPR038648|mint:Q96KE9|rcsb pdb:2VKP|reactome:R-HSA-8951664|reactome:R-HSA-983168|refseq:NP_150374.2	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:W6GIAfqNSM0aCC235lmxreYNEuw9606	rigid:smUDgv+IayQgNoB0/DJjVQKgRZ4	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q9BX70	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-710091|uniprotkb:O60418|uniprotkb:O75248|uniprotkb:Q4VBZ1|uniprotkb:Q6IAC5|uniprotkb:Q7Z5W0|uniprotkb:Q96SX8|uniprotkb:Q9NPS1|uniprotkb:Q9NX81|ensembl:ENSP00000255608	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:btbd2_human(display_long)|uniprotkb:BTBD2(gene name)|psi-mi:BTBD2(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509963|imex:IM-28561-223	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:XP_011526429.1|refseq:NP_060267.2|ensembl:ENSG00000133243(gene)|ensembl:ENST00000255608(transcript)|go:"GO:0000932"(P-body)|go:"GO:0005829"(cytosol)|go:"GO:0022008"(neurogenesis)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR012983(PHR)|interpro:IPR038648|mint:Q9BX70|rcsb pdb:3NO8	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:/G2pfpWgbGkgFcMLzMcWg5isDOE9606	rigid:FFPMWAKQbp0S8qqHM6UGccPITOQ	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q96G01	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-1104509|uniprotkb:O43892|uniprotkb:O43893|uniprotkb:A8K2C3|uniprotkb:F8W113|ensembl:ENSP00000498700	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:bicd1_human(display_long)|uniprotkb:BICD1(gene name)|psi-mi:BICD1(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509956|imex:IM-28561-1353	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_001003398.1|refseq:NP_001705.2|ensembl:ENSG00000151746(gene)|ensembl:ENST00000652176(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006396"(RNA processing)|go:"GO:0008093"(cytoskeletal anchor activity)|go:"GO:0008298"(intracellular mRNA localization)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0016020"(membrane)|go:"GO:0016032"(viral process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031871"(proteinase activated receptor binding)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034063"(stress granule assembly)|go:"GO:0034452"(dynactin binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0070840"(dynein complex binding)|go:"GO:0072385"(minus-end-directed organelle transport along microtubule)|go:"GO:0072393"(microtubule anchoring at microtubule organizing center)|go:"GO:0099503"(secretory vesicle)|go:"GO:1900275"(negative regulation of phospholipase C activity)|go:"GO:1900276"(regulation of proteinase activated receptor activity)|go:"GO:1900737"(negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|interpro:IPR018477|mint:Q96G01|reactome:R-HSA-6811436	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:/k7T2ySwKMmpWORAV8jUfsEr+3k9606	rigid:coCcg9VK/Y8zCZxC0UGdVMQSD0Y	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:O14503	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-711810|uniprotkb:Q96TD3|ensembl:ENSP00000256495	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:bhe40_human(display_long)|uniprotkb:BHLHE40(gene name)|psi-mi:BHLHE40(display_short)|uniprotkb:Differentially expressed in chondrocytes protein 1(gene name synonym)|uniprotkb:Enhancer-of-split and hairy-related protein 2(gene name synonym)|uniprotkb:Stimulated by retinoic acid gene 13 protein(gene name synonym)|uniprotkb:BHLHB2(gene name synonym)|uniprotkb:DEC1(gene name synonym)|uniprotkb:SHARP2(gene name synonym)|uniprotkb:STRA13(gene name synonym)|uniprotkb:Class B basic helix-loop-helix protein 2(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509947|imex:IM-28561-669	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	ensembl:ENSG00000134107(gene)|ensembl:ENST00000256495(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0016604"(nuclear body)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043426"(MRF binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046982"(protein heterodimerization activity)|refseq:NP_003661.1|dip:DIP-36698N|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070888"(E-box binding)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR003650(Orange)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|mint:O14503|reactome:R-HSA-1368108	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:JZrZ1Yo2PF33s9Lf8rLTHCqoptk9606	rigid:nXVlGofwqwNp+FLN2ReX8/zv0rw	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q7L4P6	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-724373|ensembl:ENSP00000360899|uniprotkb:D3DQ27|uniprotkb:Q96A62|uniprotkb:Q9HAI3|intact:EBI-3044085	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:bend5_human(display_long)|uniprotkb:BEND5(gene name)|psi-mi:BEND5(display_short)|uniprotkb:C1orf165(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509938|imex:IM-28561-1583	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_078879.2|ensembl:ENSG00000162373(gene)|ensembl:ENST00000371833(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR018379|interpro:IPR040391|mint:Q7L4P6|refseq:NP_001289011.1|refseq:XP_011540444.1|refseq:XP_016857823.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:R6OwgNU76FX6tqLRdHVmzEgK8EE9606	rigid:hvQDpCIEpqWRJO5QvQ/FgJg9aCA	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:O14874	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-1046765|uniprotkb:Q96IN5|uniprotkb:Q6FGL4|intact:EBI-1210327|uniprotkb:A8MY43|uniprotkb:Q96G95|ensembl:ENSP00000219794|ensembl:ENSP00000378405	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:bckd_human(display_long)|uniprotkb:Branched-chain alpha-ketoacid dehydrogenase kinase(gene name synonym)|uniprotkb:BCKDK(gene name)|psi-mi:BCKDK(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509931|imex:IM-28561-1581	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_005872.2|go:"GO:0005947"(mitochondrial alpha-ketoglutarate dehydrogenase complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006550"(isoleucine catabolic process)|go:"GO:0006552"(leucine catabolic process)|go:"GO:0006574"(valine catabolic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0009063"(cellular amino acid catabolic process)|go:"GO:0009083"(branched-chain amino acid catabolic process)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0045763"(negative regulation of cellular amino acid metabolic process)|go:"GO:0047323"("[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity")|interpro:IPR003594(ATP-binding region, ATPase-like)|refseq:NP_001116429.1|refseq:NP_001258855.1|interpro:IPR004358(Signal transduction histidine kinase-related protein, C-terminal)|interpro:IPR005467(Signal transduction histidine kinase, core)|interpro:IPR018955|go:"GO:0005759"(mitochondrial matrix)|interpro:IPR036784|interpro:IPR036890|interpro:IPR039028|mint:O14874|reactome:R-HSA-70895|ensembl:ENSG00000103507(gene)|ensembl:ENST00000219794(transcript)|ensembl:ENST00000394951(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004740"("pyruvate dehydrogenase (acetyl-transferring) kinase activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:0hiSb7/qtSPoHt/cmLnUo7Gq6OI9606	rigid:IB97Kv8Qfumvh0Rkjxhh1D/P4qc	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q9Y2T1	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-4400025|uniprotkb:Q3MJ88|uniprotkb:Q9H3M6|uniprotkb:Q9UH84|ensembl:ENSP00000302625	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:axin2_human(display_long)|uniprotkb:AXIN2(gene name)|psi-mi:AXIN2(display_short)|uniprotkb:Axin-like protein(gene name synonym)|uniprotkb:Axis inhibition protein 2(gene name synonym)|uniprotkb:Conductin(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509924|imex:IM-28561-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_004646.3|dip:DIP-59293N|ensembl:ENSG00000168646(gene)|ensembl:ENST00000307078(transcript)|go:"GO:0001756"(somitogenesis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001957"(intramembranous ossification)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003413"(chondrocyte differentiation involved in endochondral bone morphogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0030282"(bone mineralization)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032423"(regulation of mismatch repair)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042476"(odontogenesis)|go:"GO:0043570"(maintenance of DNA repeat elements)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0061181"(regulation of chondrocyte development)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070602"(regulation of centromeric sister chromatid cohesion)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR001158(DIX)|interpro:IPR014936(Axin beta-catenin binding)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR029071|interpro:IPR032101|interpro:IPR036305|interpro:IPR038207|interpro:IPR043581|mint:Q9Y2T1|reactome:R-HSA-201681|reactome:R-HSA-4411364|reactome:R-HSA-4641257|reactome:R-HSA-5689880	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:Tz6ggQ7gnpx/kUUmlEUumOQjJvI9606	rigid:Fl4y1JRVIpKKMMIhzwxH7PjpcHs	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:O15169	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-710484|uniprotkb:Q4TT26|uniprotkb:Q4TT27|ensembl:ENSP00000262320|uniprotkb:Q86YA7|uniprotkb:Q8WVW6|uniprotkb:Q96S28	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:axin1_human(display_long)|uniprotkb:Axis inhibition protein 1(gene name synonym)|uniprotkb:AXIN1(gene name)|psi-mi:AXIN1(display_short)|uniprotkb:AXIN(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509915|imex:IM-28561-1111	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_003493.1|refseq:NP_851393.1|ensembl:ENSG00000103126(gene)|ensembl:ENST00000262320(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034622"|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046332"(SMAD binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0071944"(cell periphery)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR001158(DIX)|interpro:IPR014936(Axin beta-catenin binding)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR029071|interpro:IPR029797|interpro:IPR032101|interpro:IPR036305|interpro:IPR038207|interpro:IPR043581|mint:O15169|rcsb pdb:1DK8|rcsb pdb:1EMU|rcsb pdb:1O9U|rcsb pdb:3ZDI|rcsb pdb:4B7T|rcsb pdb:4NM0|rcsb pdb:4NM3|rcsb pdb:4NM5|rcsb pdb:4NM7|rcsb pdb:4NU1|rcsb pdb:5WZZ|rcsb pdb:6JCK|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-201681|reactome:R-HSA-4641257|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5689880|reactome:R-HSA-8931987|reactome:R-HSA-8939256|reactome:R-HSA-9018519|dip:DIP-34630N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:uO+LxY/7ibIZqdd5onbfXqGAZeo9606	rigid:E2i6ZTSu8KNIa+NertZCP5fwBeE	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:P54259	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-945980|uniprotkb:Q99495|uniprotkb:Q99621|uniprotkb:Q9UEK7|ensembl:ENSP00000349076|ensembl:ENSP00000379915	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:atn1_human(display_long)|uniprotkb:ATN1(gene name)|psi-mi:ATN1(display_short)|uniprotkb:DRPLA(gene name synonym)|uniprotkb:Dentatorubral-pallidoluysian atrophy protein(gene name synonym)|uniprotkb:D12S755E(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26509906|imex:IM-28561-879	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_001007027.1|refseq:NP_001931.2|ensembl:ENSP00000349076|ensembl:ENSP00000379915|dip:DIP-29423N|ensembl:ENSG00000111676(gene)|ensembl:ENST00000356654(transcript)|ensembl:ENST00000396684(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0007417"(central nervous system development)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030054"(cell junction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|interpro:IPR002951(Atrophin)|interpro:IPR017993|mint:P54259|reactome:R-HSA-8943724	-	-	crc64:B47603486C672637	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:SX8MuZ4aW8/PJmQl4HqY+NOSxbI9606	rigid:0Nn+gLmcESt6If9/089JToA92Fg	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:P31146	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-1046676|ensembl:ENSP00000219150|ensembl:ENSP00000455552|uniprotkb:Q2YD73|uniprotkb:B2RBL1	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:cor1a_human(display_long)|uniprotkb:Coronin-like protein p57(gene name synonym)|uniprotkb:Coronin-like protein A(gene name synonym)|uniprotkb:Tryptophan aspartate-containing coat protein(gene name synonym)|uniprotkb:CORO1A(gene name)|psi-mi:CORO1A(display_short)|uniprotkb:CORO1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510188|imex:IM-28561-1361	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_001180262.1|refseq:NP_009005.1|ensembl:ENSG00000102879(gene)|ensembl:ENST00000219150(transcript)|ensembl:ENST00000570045(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001845"(phagolysosome assembly)|go:"GO:0001891"(phagocytic cup)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0003785"(actin monomer binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006909"(phagocytosis)|go:"GO:0007015"(actin filament organization)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031339"(negative regulation of vesicle fusion)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0032036"(myosin heavy chain binding)|go:"GO:0032796"(uropod organization)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0038180"(nerve growth factor signaling pathway)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043320"(natural killer cell degranulation)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0051015"(actin filament binding)|go:"GO:0051126"(negative regulation of actin nucleation)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0061502"(early endosome to recycling endosome transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0045087"(innate immune response)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR001680(WD40 repeat)|interpro:IPR015048(Region of unknown function DUF1899)|interpro:IPR015049(Region of unknown function DUF1900)|interpro:IPR015505(Coronin)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR029508|interpro:IPR036322|mint:P31146|reactome:R-HSA-9636383|interpro:IPR019775|refseq:XP_011544016.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:p2NmQ7YE3FUzyW0Op4rLPLFaVVU9606	rigid:3tuWfnTmFYYGUjCEnjwU9Vonz/c	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:P38432	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-945751|uniprotkb:B2R931|ensembl:ENSP00000240316	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:coil_human(display_long)|uniprotkb:COIL(gene name)|psi-mi:COIL(display_short)|uniprotkb:CLN80(gene name synonym)|uniprotkb:p80-coilin(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510181|imex:IM-28561-231	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_004636.1|dip:DIP-38503N|ensembl:ENSG00000121058(gene)|ensembl:ENST00000240316(transcript)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0001650"(fibrillar center)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0015030"(Cajal body)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0030619"(U1 snRNA binding)|go:"GO:0030620"(U2 snRNA binding)|go:"GO:0042802"(identical protein binding)|interpro:IPR024822|interpro:IPR031722|mint:P38432	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:hd5p6AbyA/GYNEeca99Mdb41qM09606	rigid:xPLjAMLI9bFvG2l+flF8n3W/y+Q	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q86X95	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-627102|ensembl:ENSP00000339723|uniprotkb:A6NFI6|uniprotkb:A8K8M4|uniprotkb:O95367|uniprotkb:Q12804|uniprotkb:Q4G1B9|uniprotkb:Q6PJI4|uniprotkb:Q8IWI2	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:cir1_human(display_long)|uniprotkb:CIR(gene name synonym)|uniprotkb:CBF1-interacting corepressor(gene name synonym)|uniprotkb:Recepin(gene name synonym)|uniprotkb:CIR1(gene name)|psi-mi:CIR1(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510174|imex:IM-28561-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	ensembl:ENSG00000138433(gene)|ensembl:ENST00000342016(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR019339|interpro:IPR040014|mint:Q86X95|rcsb pdb:6ZYM|refseq:NP_004873.3	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:DMnBG746eQpvLsf9D+lgeUKnni09606	rigid:+PmiKkve5J70Kqp9o20g3ziEHac	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q9H2X0	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-947551|intact:EBI-1752274|uniprotkb:O95254|uniprotkb:Q2M1I8|uniprotkb:Q6UW83|uniprotkb:Q9H2D3|uniprotkb:Q9H2W8|uniprotkb:Q9H2W9|uniprotkb:Q9P0Z2|uniprotkb:Q9P0Z3|uniprotkb:Q9P0Z4|uniprotkb:Q9P0Z5|intact:EBI-1957537|ensembl:ENSP00000204604	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:chrd_human(display_long)|uniprotkb:CHRD(gene name)|psi-mi:CHRD(display_short)|uniprotkb:UNQ217/PRO243(orf name)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510165|imex:IM-28561-229	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_003732.2|refseq:NP_001291401.1|refseq:NP_001291402.1|refseq:NP_001291403.1|dip:DIP-48857N|ensembl:ENSG00000090539(gene)|ensembl:ENST00000204604(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0005615"(extracellular space)|go:"GO:0019955"(cytokine binding)|go:"GO:0021919"(BMP signaling pathway involved in spinal cord dorsal/ventral patterning)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0033504"(floor plate development)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR010895(CHRD)|interpro:IPR016353(Chordin)|mint:Q9H2X0	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:Y/WHkB30K8nEcaaL2wyikwWH1kg9606	rigid:KPiqWotaOK1l1GXb/ilCyIFP4j0	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q9P209	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-739498|uniprotkb:Q9BV03|uniprotkb:Q9BWM3|uniprotkb:Q9NVR4|uniprotkb:B4DR26|ensembl:ENSP00000264935	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:cep72_human(display_long)|uniprotkb:CEP72(gene name)|psi-mi:CEP72(display_short)|uniprotkb:KIAA1519(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510158|imex:IM-28561-679	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_060610.2|ensembl:ENSG00000112877(gene)|ensembl:ENST00000264935(transcript)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007051"(spindle organization)|go:"GO:0007099"(centriole replication)|go:"GO:0033566"(gamma-tubulin complex localization)|go:"GO:0034451"(centriolar satellite)|go:"GO:1904779"(regulation of protein localization to centrosome)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR003603(U2A'/phosphoprotein 32 family A, C-terminal)|interpro:IPR032675|interpro:IPR040146|mint:Q9P209|reactome:R-HSA-2565942|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-8854518|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|refseq:XP_011512365.1|dip:DIP-54272N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:c00WdgE2iudiQUz3kXNZL5d0nuQ9606	rigid:+oiTd/UdyNdKbtfOC+Qt9NYyqrk	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q9Y232	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-1387386|uniprotkb:Q0VDG7|uniprotkb:Q32NC5|uniprotkb:Q5VX99|uniprotkb:Q6P7T5|uniprotkb:Q9BWZ2|uniprotkb:Q9Y424|uniprotkb:A8K6D6|uniprotkb:B4DLG4|ensembl:ENSP00000330512	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:cdyl_human(display_long)|uniprotkb:Crotonyl-CoA hydratase(gene name synonym)|uniprotkb:CDYL(gene name)|psi-mi:CDYL(display_short)|uniprotkb:CDYL1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510149|imex:IM-28561-1591	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_001137442.1|refseq:NP_001137443.1|refseq:NP_004815.3|interpro:IPR000953(Chromo domain)|interpro:IPR001753(Crotonase, core)|interpro:IPR014748(Crontonase, C-terminal)|interpro:IPR016197(Chromo domain-like)|interpro:IPR023779|interpro:IPR023780|interpro:IPR029045|mint:Q9Y232|ensembl:ENSG00000153046(gene)|ensembl:ENST00000328908(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007286"(spermatid development)|go:"GO:0016607"(nuclear speck)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0035064"(methylated histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0060816"(random inactivation of X chromosome)|go:"GO:0120092"(crotonyl-CoA hydratase activity)|go:"GO:0120094"(negative regulation of peptidyl-lysine crotonylation)|rcsb pdb:2DNT|rcsb pdb:2GTR	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:np0RERcg3R8KbgTKXhy50/ytvXg9606	rigid:J40r928H7w89sNKmerHTPVgQ81g	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q01850	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-1181367|uniprotkb:Q13977|uniprotkb:A8K8A8|ensembl:ENSP00000268383	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:cdr2_human(display_long)|uniprotkb:Paraneoplastic cerebellar degeneration-associated antigen(gene name synonym)|uniprotkb:Major Yo paraneoplastic antigen(gene name synonym)|uniprotkb:CDR2(gene name)|psi-mi:CDR2(display_short)|uniprotkb:PCD17(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510140|imex:IM-28561-435	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_001793.1|ensembl:ENSG00000140743(gene)|ensembl:ENST00000268383(transcript)|interpro:IPR026079|mint:Q01850|refseq:XP_005276559.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:TYCAl4weno3VU167nI6ARIiWQZY9606	rigid:KqyMYurkaF29jv7K9J2gW+gg+W0	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q96ST8	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-2799206|uniprotkb:Q8N5J8|uniprotkb:B9EGA6|ensembl:ENSP00000306105	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:cep89_human(display_long)|uniprotkb:CCDC123(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 123(gene name synonym)|uniprotkb:CEP89(gene name)|psi-mi:CEP89(display_short)|uniprotkb:Centrosomal protein 123(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510117|imex:IM-28561-1589	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:XP_011525727.1|refseq:NP_116205.3|ensembl:ENSG00000121289(gene)|ensembl:ENST00000305768(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0031514"(motile cilium)|go:"GO:0060271"(cilium assembly)|go:"GO:0097539"(ciliary transition fiber)|go:"GO:0097730"(non-motile cilium)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR033545|mint:Q96ST8|reactome:R-HSA-5620912|go:"GO:0045202"(synapse)|dip:DIP-47325N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:u/Ov7ZA+Q741uaCU5woCf7Iz3zE9606	rigid:Ittry9je6H34pjZROFZNDHCl2LQ	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:O95967	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-743414|uniprotkb:O75967|uniprotkb:A8K7R4|uniprotkb:B3KM31|uniprotkb:B3KQT1|ensembl:ENSP00000309953|ensembl:ENSP00000435295	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:fbln4_human(display_long)|uniprotkb:Fibulin-4(gene name synonym)|uniprotkb:Protein UPH1(gene name synonym)|uniprotkb:EFEMP2(gene name)|psi-mi:EFEMP2(display_short)|uniprotkb:FBLN4(gene name synonym)|uniprotkb:UNQ200/PRO226(orf name)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510339|imex:IM-28561-23	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_058634.4|ensembl:ENSG00000172638(gene)|ensembl:ENST00000307998(transcript)|ensembl:ENST00000531972(transcript)|go:"GO:0001527"(microfibril)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0008201"(heparin binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035904"(aorta development)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0048251"(elastic fiber assembly)|go:"GO:0060414"(aorta smooth muscle tissue morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071953"(elastic fiber)|go:"GO:0097084"(vascular associated smooth muscle cell development)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1904026"(regulation of collagen fibril organization)|go:"GO:1904028"(positive regulation of collagen fibril organization)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904831"(positive regulation of aortic smooth muscle cell differentiation)|go:"GO:1905609"(positive regulation of smooth muscle cell-matrix adhesion)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR018097|interpro:IPR026823|interpro:IPR026824|mint:O95967|rcsb pdb:2KL7|reactome:R-HSA-2129379|dip:DIP-34518N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:L8jMp8rFYb6DRRusfWgyd9zN2KI9606	rigid:Fi0zRd+SW3AuOQ8dl/KSGgt4zmo	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q9BR76	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-351152|uniprotkb:B2RD45|ensembl:ENSP00000340211|ensembl:ENSP00000377471	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:cor1b_human(display_long)|uniprotkb:CORO1B(gene name)|psi-mi:CORO1B(display_short)|uniprotkb:Coronin-2(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510207|imex:IM-28561-437	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_001018080.1|refseq:NP_065174.1|ensembl:ENSG00000172725(gene)|ensembl:ENST00000341356(transcript)|ensembl:ENST00000393893(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0016477"(cell migration)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031252"(cell leading edge)|go:"GO:0031529"(ruffle organization)|go:"GO:0034315"(regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0034316"(negative regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071672"(negative regulation of smooth muscle cell chemotaxis)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0071944"(cell periphery)|go:"GO:0090135"(actin filament branching)|go:"GO:1902463"(protein localization to cell leading edge)|go:"GO:2000394"(positive regulation of lamellipodium morphogenesis)|interpro:IPR001680(WD40 repeat)|interpro:IPR015048(Region of unknown function DUF1899)|interpro:IPR015505(Coronin)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR027340|interpro:IPR036322|mint:Q9BR76|go:"GO:0035767"(endothelial cell chemotaxis)|dip:DIP-33176N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:80hrtgIbLoisOZLGgfaa1TLBFMg9606	rigid:gDeK8oJWwLNYki5KwzJmrZd7uSQ	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q16610	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-947964|ensembl:ENSP00000358043|uniprotkb:A8K8S0|uniprotkb:B4DW49|uniprotkb:B4DY60|uniprotkb:O43266|uniprotkb:Q5T5G4|uniprotkb:Q5T5G5|uniprotkb:Q5T5G6|uniprotkb:Q8IZ60	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:ecm1_human(display_long)|uniprotkb:Secretory component p85(gene name synonym)|uniprotkb:ECM1(gene name)|psi-mi:ECM1(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510323|imex:IM-28561-1599	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	ensembl:ENSG00000143369(gene)|ensembl:ENST00000369047(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001525"(angiogenesis)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|refseq:NP_001189787.1|refseq:NP_004416.2|refseq:NP_073155.2|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010466"(negative regulation of peptidase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030500"(regulation of bone mineralization)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031089"(platelet dense granule lumen)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043236"(laminin binding)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR008605(Extracellular matrix 1)|interpro:IPR020858|mint:Q16610|reactome:R-HSA-114608|go:"GO:0001960"(negative regulation of cytokine-mediated signaling pathway)|go:"GO:0002020"(protease binding)|go:"GO:0002063"(chondrocyte development)|go:"GO:0002828"(regulation of type 2 immune response)|go:"GO:0003416"(endochondral bone growth)|go:"GO:0005134"(interleukin-2 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:Dgo43cKlqBAYL6tWVb9B63CuY+Q9606	rigid:teO8eQFkvGIVAIiRUYba0wCien4	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:P30084	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-719602|uniprotkb:O00739|uniprotkb:Q5VWY1|uniprotkb:Q96H54|ensembl:ENSP00000357535	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:echm_human(display_long)|uniprotkb:Short-chain enoyl-CoA hydratase(gene name synonym)|uniprotkb:Enoyl-CoA hydratase 1(gene name synonym)|uniprotkb:ECHS1(gene name)|psi-mi:ECHS1(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510314|imex:IM-28561-891	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_004083.3|ensembl:ENSG00000127884(gene)|ensembl:ENST00000368547(transcript)|go:"GO:0004300"(enoyl-CoA hydratase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0009083"(branched-chain amino acid catabolic process)|go:"GO:0043956"(3-hydroxypropionyl-CoA dehydratase activity)|interpro:IPR001753(Crotonase, core)|interpro:IPR014748(Crontonase, C-terminal)|interpro:IPR018376|interpro:IPR029045|mint:P30084|rcsb pdb:2HW5|reactome:R-HSA-70895|reactome:R-HSA-77310|reactome:R-HSA-77346|reactome:R-HSA-77348|reactome:R-HSA-77350|reactome:R-HSA-77352|go:"GO:0120092"(crotonyl-CoA hydratase activity)	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:zXekfKfyCbjaTVLTdDdAuMgiDco9606	rigid:HOeYfUDZdU46KBgv0JAmx0z4ioo	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q13011	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-711968|ensembl:ENSP00000221418|ensembl:ENSP00000489530|uniprotkb:Q8WVX0|uniprotkb:Q96EZ9|uniprotkb:A8K745	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:ech1_human(display_long)|uniprotkb:ECH1(gene name)|psi-mi:ECH1(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510305|imex:IM-28561-681	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	ensembl:ENSG00000104823(gene)|ensembl:ENSG00000282853(gene)|ensembl:ENST00000221418(transcript)|ensembl:ENST00000634245(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005777"(peroxisome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0016020"(membrane)|go:"GO:0051750"("delta(3,5)-delta(2,4)-dienoyl-CoA isomerase activity")|go:"GO:0070062"(extracellular exosome)|interpro:IPR001753(Crotonase, core)|interpro:IPR014748(Crontonase, C-terminal)|interpro:IPR018376|interpro:IPR029045|mint:Q13011|rcsb pdb:2VRE|reactome:R-HSA-9033241|refseq:NP_001389.2	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:gh0bwdUu9tkSTHWuySCaTXIQGzI9606	rigid:EIbJnxRLTq3A+i9zvfIPlfTq/34	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:P50570	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-346547|uniprotkb:Q7Z5S3|uniprotkb:Q5I0Y0|uniprotkb:Q9UPH4|intact:EBI-3959204|uniprotkb:A8K1B6|uniprotkb:E7EV30|uniprotkb:K7ESI9|intact:EBI-5912046|uniprotkb:E9PEQ4|ensembl:ENSP00000347890	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:dyn2_human(display_long)|uniprotkb:DNM2(gene name)|psi-mi:DNM2(display_short)|uniprotkb:DYN2(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510296|imex:IM-28561-445	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_004936.2|refseq:NP_001005360.1|refseq:NP_001005361.1|refseq:NP_001005362.1|refseq:NP_001177645.1|dip:DIP-31244N|reactome:R-HSA-203641|reactome:R-HSA-2132295|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-437239|reactome:R-HSA-8856828|reactome:R-HSA-9031628|reactome:R-HSA-196025|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031749"(D2 dopamine receptor binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033572"(transferrin transport)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044351"(macropinocytosis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050699"(WW domain binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0061024"(membrane organization)|go:"GO:0061025"(membrane fusion)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071245"(cellular response to carbon monoxide)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0098793"(presynapse)|go:"GO:0098844"(postsynaptic endocytic zone membrane)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902856"(negative regulation of non-motile cilium assembly)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903358"(regulation of Golgi organization)|go:"GO:1903408"("positive regulation of P-type sodium:potassium-exchanging transporter activity")|go:"GO:1903526"(negative regulation of membrane tubulation)|go:"GO:2000370"(positive regulation of clathrin-dependent endocytosis)|interpro:IPR000375(Dynamin central region)|interpro:IPR001401(Dynamin, GTPase region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR003130(Dynamin GTPase effector)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019762|interpro:IPR020850|interpro:IPR022812|interpro:IPR027188|interpro:IPR027417|interpro:IPR030381|mint:P50570|rcsb pdb:2YS1|reactome:R-HSA-166016|reactome:R-HSA-177504|reactome:R-HSA-190873|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008017"(microtubule binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016185"(synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|ensembl:ENSG00000079805(gene)|ensembl:ENST00000355667(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0001891"(phagocytic cup)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0003374"(dynamin family protein polymerization involved in mitochondrial fission)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005925"(focal adhesion)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0006897"(endocytosis)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:BAUEy6Iju72PTot46Xhz75cQTQs9606	rigid:UUv15Pl4BKIVe3fbe70M+dvMxmI	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q96EY1	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-356767|uniprotkb:O75472|uniprotkb:Q8WUJ6|uniprotkb:Q8WXJ3|uniprotkb:Q96D76|uniprotkb:Q96IV1|uniprotkb:Q9NYH8|uniprotkb:B2RAJ5|uniprotkb:B4DI33|uniprotkb:E7ES32|ensembl:ENSP00000262375|ensembl:ENSP00000477570	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:dnja3_human(display_long)|uniprotkb:DNAJA3(gene name)|psi-mi:DNAJA3(display_short)|uniprotkb:TID1(gene name synonym)|uniprotkb:HCA57(gene name synonym)|uniprotkb:Tumorous imaginal discs protein Tid56 homolog(gene name synonym)|uniprotkb:DnaJ protein Tid-1(gene name synonym)|uniprotkb:Hepatocellular carcinoma-associated antigen 57(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510287|imex:IM-28561-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_001273445.1|refseq:NP_001128582.1|refseq:NP_005138.3|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060336"(negative regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0071340"(skeletal muscle acetylcholine-gated channel clustering)|go:"GO:0106137"(IkappaB kinase complex binding)|interpro:IPR001305(Heat shock protein DnaJ, cysteine-rich region)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR008971(HSP40/DnaJ peptide-binding)|interpro:IPR012724(Chaperone DnaJ)|interpro:IPR018253|interpro:IPR036410|interpro:IPR036869|mint:Q96EY1|rcsb pdb:2CTT|rcsb pdb:2DN9|rcsb pdb:6IWS|ensembl:ENSG00000103423(gene)|ensembl:ENSG00000276726(gene)|ensembl:ENST00000262375(transcript)|ensembl:ENST00000612103(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005133"(interferon-gamma receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006264"(mitochondrial DNA replication)|go:"GO:0006457"(protein folding)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006924"(activation-induced cell death of T cells)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0007569"(cell aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009408"(response to heat)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0030695"(GTPase regulator activity)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051059"(NF-kappaB binding)|dip:DIP-33870N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:WnRYdQ9E3yGbSlq1SSGTX9k+3uA9606	rigid:nFdIECIDcKpPa5QfwFbYMJ2o3gA	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:O75398	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-718185|uniprotkb:O15152|uniprotkb:O75399|uniprotkb:O75510|uniprotkb:O75511|uniprotkb:O75512|uniprotkb:O75513|uniprotkb:Q9UET1|uniprotkb:A8K5R8|uniprotkb:A8K1F8|uniprotkb:C7T5V5|intact:EBI-28974412|ensembl:ENSP00000371846	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:deaf1_human(display_long)|uniprotkb:Nuclear DEAF-1-related transcriptional regulator(gene name synonym)|uniprotkb:Suppressin(gene name synonym)|uniprotkb:Zinc finger MYND domain-containing protein 5(gene name synonym)|uniprotkb:DEAF1(gene name)|psi-mi:DEAF1(display_short)|uniprotkb:SPN(gene name synonym)|uniprotkb:ZMYND5(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510278|imex:IM-28561-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_066288.2|ensembl:ENSP00000371846|refseq:NP_001280563.1|ensembl:ENSG00000177030(gene)|ensembl:ENST00000382409(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001650"(fibrillar center)|go:"GO:0001843"(neural tube closure)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007281"(germ cell development)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0033599"(regulation of mammary gland epithelial cell proliferation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0048706"(embryonic skeletal system development)|interpro:IPR000770(SAND)|interpro:IPR002893(Zinc finger, MYND-type)|interpro:IPR010919(SAND-like)|interpro:IPR024119|mint:O75398|rcsb pdb:2JW6|rcsb pdb:4A24|rcsb pdb:5UWW	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:2wVDKJ2CcROUYc5whZI3JWATnI89606	rigid:LiT6Zd5kT9UTvdvkfAE4/SC5tIE	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q9H773	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-723569|intact:EBI-1384169|ensembl:ENSP00000322524	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:dctp1_human(display_long)|uniprotkb:DCTPP1(gene name)|psi-mi:DCTPP1(display_short)|uniprotkb:RS21C6(gene name synonym)|uniprotkb:CDA03(orf name)|uniprotkb:XTP3TPA(gene name synonym)|uniprotkb:Deoxycytidine-triphosphatase 1(gene name synonym)|uniprotkb:XTP3-transactivated gene A protein(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510269|imex:IM-28561-1597	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_077001.1|ensembl:ENST00000319285(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006253"(dCTP catabolic process)|go:"GO:0009143"(nucleoside triphosphate catabolic process)|go:"GO:0032556"(pyrimidine deoxyribonucleotide binding)|go:"GO:0042262"(DNA protection)|go:"GO:0042802"(identical protein binding)|go:"GO:0047429"(nucleoside-triphosphate diphosphatase activity)|go:"GO:0047840"(dCTP diphosphatase activity)|interpro:IPR025984|mint:Q9H773|reactome:R-HSA-499943|ensembl:ENSG00000179958(gene)	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:4EfV2ZU2MgDiFXShthfualZnat09606	rigid:7N80RD/p+Gn1Ms7npDayuqpVFX4	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q13561	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-715074|uniprotkb:Q86YN2|uniprotkb:Q9BW17|uniprotkb:B2RBK5|ensembl:ENSP00000447824	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:dctn2_human(display_long)|uniprotkb:Dynactin complex 50 kDa subunit(gene name synonym)|uniprotkb:50 kDa dynein-associated polypeptide(gene name synonym)|uniprotkb:p50 dynamitin(gene name synonym)|uniprotkb:DCTN2(gene name)|psi-mi:DCTN2(display_short)|uniprotkb:DCTN50(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510260|imex:IM-28561-889	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_006391.1|refseq:NP_001248341.1|refseq:NP_001248342.1|dip:DIP-37545N|reactome:R-HSA-2565942|reactome:R-HSA-3371497|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-6807878|reactome:R-HSA-6811436|reactome:R-HSA-8854518|ensembl:ENSG00000175203(gene)|ensembl:ENST00000548249(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005869"(dynactin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030286"(dynein complex)|go:"GO:0030426"(growth cone)|go:"GO:0030507"(spectrin binding)|go:"GO:0031982"(vesicle)|go:"GO:0032402"(melanosome transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071539"(protein localization to centrosome)|interpro:IPR028133|mint:Q13561|reactome:R-HSA-2132295	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:JrL5jUtArek+zqmCkPKomnjuSf09606	rigid:zj/8l6cADjmMmKE7R3SNzUAv+lY	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q14203	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-724352|uniprotkb:O95296|uniprotkb:Q9BRM9|uniprotkb:Q9UIU1|intact:EBI-28971695|ensembl:ENSP00000487279|uniprotkb:Q9UIU2|uniprotkb:E9PGE1|uniprotkb:G5E9H4|uniprotkb:Q6IQ37|intact:EBI-2560059|uniprotkb:B4DM45|uniprotkb:E9PFS5|uniprotkb:A8MY36|intact:EBI-10962300	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:dctn1_human(display_long)|uniprotkb:DCTN1(gene name)|psi-mi:DCTN1(display_short)|uniprotkb:150 kDa dynein-associated polypeptide(gene name synonym)|uniprotkb:DAP-150(gene name synonym)|uniprotkb:p150-glued(gene name synonym)|uniprotkb:p135(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510253|imex:IM-28561-1595	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_001128512.1|refseq:NP_001128513.1|refseq:NP_001177766.1|refseq:NP_004073.2|refseq:NP_075408.1|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-381038|reactome:R-HSA-5620912|reactome:R-HSA-6807878|reactome:R-HSA-6811436|reactome:R-HSA-8854518|reactome:R-HSA-380259|ensembl:ENSG00000204843(gene)|ensembl:ENST00000628224(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005938"(cell cortex)|go:"GO:0007097"(nuclear migration)|go:"GO:0007399"(nervous system development)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008017"(microtubule binding)|go:"GO:0010457"(centriole-centriole cohesion)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0015631"(tubulin binding)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021517"(ventral spinal cord development)|go:"GO:0030286"(dynein complex)|go:"GO:0030424"(axon)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0034454"(microtubule anchoring at centrosome)|go:"GO:0035371"(microtubule plus-end)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045171"(intercellular bridge)|go:"GO:0048156"(tau protein binding)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051081"(nuclear membrane disassembly)|go:"GO:0051301"(cell division)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0061744"(motor behavior)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0099558"(maintenance of synapse structure)|go:"GO:0099738"(cell cortex region)|go:"GO:0120103"(centriolar subdistal appendage)|go:"GO:1904398"(positive regulation of neuromuscular junction development)|go:"GO:1905515"(non-motile cilium assembly)|go:"GO:1990535"(neuron projection maintenance)|interpro:IPR000938(Cytoskeleton-associated protein, CAP-Gly)|interpro:IPR022157|interpro:IPR036859|mint:Q14203|rcsb pdb:1TXQ|rcsb pdb:2COY|rcsb pdb:2HKN|rcsb pdb:2HKQ|rcsb pdb:2HL3|rcsb pdb:2HL5|rcsb pdb:2HQH|rcsb pdb:3E2U|rcsb pdb:3TQ7|reactome:R-HSA-2132295|reactome:R-HSA-2565942|reactome:R-HSA-3371497|ensembl:ENST00000394003|ensembl:ENSP00000377571|ensembl:ENST00000409240|ensembl:ENSP00000386406|ensembl:ENST00000409438|ensembl:ENSP00000387270|ensembl:ENST00000409567|ensembl:ENSP00000386843|ensembl:ENSP00000487279|ensembl:ENST00000633691|ensembl:ENSP00000487724|refseq:NP_001177765.1|dip:DIP-31365N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:PKchWdLWycCErGzSVMXq/xCQJRM9606	rigid:+dMcDf1XjOrEPwPstPuzaknr5dg	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:P32321	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-739870|uniprotkb:Q9BVD8|uniprotkb:B2R836|uniprotkb:Q5M7Z8|uniprotkb:D3DP49|uniprotkb:D3DP50|ensembl:ENSP00000398194|ensembl:ENSP00000424017	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:dctd_human(display_long)|uniprotkb:DCTD(gene name)|psi-mi:DCTD(display_short)|uniprotkb:dCMP deaminase(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510246|imex:IM-28561-443	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_001012750.1|refseq:NP_001912.2|ensembl:ENSG00000129187(gene)|ensembl:ENST00000438320(transcript)|ensembl:ENST00000510370(transcript)|go:"GO:0004132"(dCMP deaminase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006220"(pyrimidine nucleotide metabolic process)|go:"GO:0006226"(dUMP biosynthetic process)|go:"GO:0006231"(dTMP biosynthetic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0042802"(identical protein binding)|interpro:IPR002125(CMP/dCMP deaminase, zinc-binding)|interpro:IPR015517(Cytidine deaminase)|interpro:IPR016192(APOBEC/CMP deaminase, zinc-binding)|interpro:IPR016193(Cytidine deaminase-like)|interpro:IPR016473(dCMP deaminase)|interpro:IPR035105|mint:P32321|rcsb pdb:2W4L|reactome:R-HSA-499943|refseq:XP_005262836.1|refseq:XP_005262837.1|refseq:XP_011529976.1|refseq:XP_016863305.1|refseq:XP_016863306.1|refseq:XP_016863307.1|refseq:XP_016863308.1|refseq:XP_016863309.1|refseq:XP_016863310.1|refseq:XP_016863311.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:lU3gEi7XdIJbuPlMkForbVKEOyY9606	rigid:sZcJcmppYMeMY4vgISDuhnHl+lM	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q5M775	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-350473|uniprotkb:Q5IBP1|uniprotkb:Q5IBP2|uniprotkb:Q5IBP3|uniprotkb:Q5IBP4|uniprotkb:Q5M772|uniprotkb:Q5M773|uniprotkb:Q5M774|uniprotkb:Q86XT8|uniprotkb:Q8N4U4|uniprotkb:Q8WU84|uniprotkb:Q9HCQ3|uniprotkb:B4DHH0|ensembl:ENSP00000261503|ensembl:ENSP00000378898|ensembl:ENSP00000502924|ensembl:ENSP00000503971|ensembl:ENSP00000504211|uniprotkb:B7WNS8|intact:EBI-2556892	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:cytsb_human(display_long)|uniprotkb:Nuclear structure protein 5(gene name synonym)|uniprotkb:Sperm antigen HCMOGT-1(gene name synonym)|uniprotkb:SPECC1(gene name)|psi-mi:SPECC1(display_short)|uniprotkb:CYTSB(gene name synonym)|uniprotkb:Sperm antigen with calponin homology and coiled-coil domains 1(gene name synonym)|uniprotkb:NSP5(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510239|imex:IM-28561-887	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_001028725.1|refseq:NP_001028726.1|refseq:NP_001028727.1|refseq:NP_001230367.1|refseq:NP_001230368.1|refseq:NP_690868.3|ensembl:ENSG00000128487(gene)|ensembl:ENST00000261503(transcript)|ensembl:ENST00000395527(transcript)|ensembl:ENST00000677914(transcript)|ensembl:ENST00000679058(transcript)|ensembl:ENST00000679255(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031941"(filamentous actin)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR036872|mint:Q5M775|interpro:IPR001715(Calponin-like actin-binding)|refseq:XP_016880814.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:iF+19RpfJDyn5whTFnPmDxxECz09606	rigid:U9QuZHz4wu4DRFm/nrakqQH8mvc	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q6ZMK1	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-3908824|uniprotkb:Q9BSF6|uniprotkb:D3DWM3|uniprotkb:Q9BSU6|uniprotkb:B3KSX0|ensembl:ENSP00000387426	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:cyhr1_human(display_long)|uniprotkb:CYHR1(gene name)|psi-mi:CYHR1(display_short)|uniprotkb:KIAA0496(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510232|imex:IM-28561-441	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:XP_011515353.1|refseq:NP_001123360.1|refseq:NP_116076.1|refseq:NP_612505.1|refseq:XP_006716623.1|refseq:XP_006716624.1|ensembl:ENSG00000187954(gene)|ensembl:ENST00000438911(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR039338|mint:Q6ZMK1|refseq:NP_001317547.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:BMO2Sx7uBqM1mLPpMzUij3B+Qi09606	rigid:zl/5nC/RDJ9DWJm5L/W9T7OwbkQ	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:P67870	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-348169|ensembl:ENSP00000365025|ensembl:ENSP00000365026|ensembl:ENSP00000365042|ensembl:ENSP00000372919|ensembl:ENSP00000372925|ensembl:ENSP00000382980|ensembl:ENSP00000390900|ensembl:ENSP00000391038|ensembl:ENSP00000393756|ensembl:ENSP00000394855|ensembl:ENSP00000395275|ensembl:ENSP00000400188|ensembl:ENSP00000407018|ensembl:ENSP00000407379|ensembl:ENSP00000409510|ensembl:ENSP00000410802|ensembl:ENSP00000411322|ensembl:ENSP00000412520|ensembl:ENSP00000413469|ensembl:ENSP00000415237|ensembl:ENSP00000415303|uniprotkb:P07312|uniprotkb:P13862|uniprotkb:Q4VX47|intact:EBI-3866975|uniprotkb:B0UXA9	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:csk2b_human(display_long)|uniprotkb:Phosvitin(gene name synonym)|uniprotkb:Protein G5a(gene name synonym)|uniprotkb:CSNK2B(gene name)|psi-mi:CSNK2B(display_short)|uniprotkb:CK2N(gene name synonym)|uniprotkb:G5A(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510225|imex:IM-28561-1593	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	ensembl:ENSG00000204435(gene)|ensembl:ENSG00000230700(gene)|ensembl:ENSG00000206406(gene)|ensembl:ENSG00000232960(gene)|ensembl:ENSG00000224398(gene)|ensembl:ENSG00000224774(gene)|ensembl:ENSG00000228875(gene)|ensembl:ENST00000375882(transcript)|ensembl:ENST00000383427(transcript)|ensembl:ENST00000383433(transcript)|ensembl:ENST00000400110(transcript)|ensembl:ENST00000412802(transcript)|ensembl:ENST00000418230(transcript)|ensembl:ENST00000422567(transcript)|ensembl:ENST00000429633(transcript)|ensembl:ENST00000431476(transcript)|ensembl:ENST00000436169(transcript)|ensembl:ENST00000443673(transcript)|ensembl:ENST00000448596(transcript)|ensembl:ENST00000451917(transcript)|ensembl:ENST00000452985(transcript)|ensembl:ENST00000453234(transcript)|ensembl:ENST00000454382(transcript)|ensembl:ENST00000454511(transcript)|ensembl:ENST00000455161(transcript)|ensembl:ENST00000458330(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0005956"(protein kinase CK2 complex)|go:"GO:0007165"(signal transduction)|ensembl:ENST00000375865(transcript)|ensembl:ENST00000375866(transcript)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016363"(nuclear matrix)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032927"(positive regulation of activin receptor signaling pathway)|go:"GO:0033211"(adiponectin-activated signaling pathway)|go:"GO:0033574"(response to testosterone)|go:"GO:0034622"|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0046872"(metal ion binding)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0061154"(endothelial tube morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0080163"(regulation of protein serine/threonine phosphatase activity)|go:"GO:0097421"(liver regeneration)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000704(Casein kinase II, regulatory subunit)|interpro:IPR016149(Casein kinase II, regulatory subunit, alpha-helical)|interpro:IPR035991|mint:P67870|rcsb pdb:1DS5|rcsb pdb:1JWH|go:"GO:0008134"(transcription factor binding)|rcsb pdb:1QF8|rcsb pdb:3EED|rcsb pdb:4DGL|rcsb pdb:4MD7|rcsb pdb:4MD8|rcsb pdb:4MD9|rcsb pdb:4NH1|reactome:R-HSA-1483191|reactome:R-HSA-201688|reactome:R-HSA-2514853|reactome:R-HSA-445144|reactome:R-HSA-6798695|reactome:R-HSA-6804756|reactome:R-HSA-6814122|reactome:R-HSA-8932339|reactome:R-HSA-8934903|reactome:R-HSA-8939243|reactome:R-HSA-8948751|rcsb pdb:6Q38|refseq:NP_001311.3|refseq:NP_001269314.1|dip:DIP-131N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:ZTHJjCqHg2dE7B+WoSU28VSMuPg9606	rigid:v7/5y9pUBvmbSOFiJgGY1dds0m8	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q6QEF8	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-10254194|uniprotkb:Q8WYH7|uniprotkb:Q71MF3|uniprotkb:B3KU26|uniprotkb:Q96K02	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:coro6_human(display_long)|uniprotkb:CORO6(gene name)|psi-mi:CORO6(display_short)|uniprotkb:Coronin-like protein E(gene name synonym)|uniprotkb:PP1009(orf name)|uniprotkb:PP1782(orf name)|uniprotkb:PP1881(orf name)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510216|imex:IM-28561-439	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	interpro:IPR024977|interpro:IPR001680(WD40 repeat)|interpro:IPR015048(Region of unknown function DUF1899)|interpro:IPR015505(Coronin)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|refseq:NP_116243.2|refseq:XP_005258104.1|refseq:XP_005258113.1|go:"GO:0007015"(actin filament organization)|go:"GO:0016477"(cell migration)|go:"GO:0051015"(actin filament binding)|rcsb pdb:7KYX|mint:Q6QEF8|interpro:IPR027337|interpro:IPR036322	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:74cXNbfS0DUUtrKdyaM1XEbE/bA9606	rigid:qK2tOi5iHRJRyFHdblvmt/TH4SM	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q6P2E9	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-1006038|uniprotkb:Q13025|uniprotkb:Q13826|uniprotkb:Q6ZR12|uniprotkb:Q7Z6H7|uniprotkb:A6NGM1|uniprotkb:A8K4T4|ensembl:ENSP00000351811	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:edc4_human(display_long)|uniprotkb:Human enhancer of decapping large subunit(gene name synonym)|uniprotkb:Autoantigen Ge-1(gene name synonym)|uniprotkb:Autoantigen RCD-8(gene name synonym)|uniprotkb:EDC4(gene name)|psi-mi:EDC4(display_short)|uniprotkb:HEDLS(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510332|imex:IM-28561-1363	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	ensembl:ENSG00000038358(gene)|interpro:IPR036322|mint:Q6P2E9|reactome:R-HSA-430039|ensembl:ENST00000358933(transcript)|go:"GO:0000932"(P-body)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|go:"GO:0031087"(deadenylation-independent decapping of nuclear-transcribed mRNA)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR032401|refseq:NP_055144.3|dip:DIP-31192N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:V5obZo71xmJbNRv5fc+o7wNdb+Y9606	rigid:x9Mz/XKpKGhdfMQ4Eu3YJNt1XEM	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q16352	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-366258|uniprotkb:Q9BRC5|uniprotkb:B1AQK0|ensembl:ENSP00000358865	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:ainx_human(display_long)|uniprotkb:INA(gene name)|psi-mi:INA(display_short)|uniprotkb:66 kDa neurofilament protein(gene name synonym)|uniprotkb:Neurofilament 5(gene name synonym)|uniprotkb:NEF5(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510608|imex:IM-28561-35	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_116116.1|ensembl:ENSG00000148798(gene)|ensembl:ENST00000369849(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005615"(extracellular space)|go:"GO:0005883"(neurofilament)|go:"GO:0021762"(substantia nigra development)|go:"GO:0030154"(cell differentiation)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0060052"(neurofilament cytoskeleton organization)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098973"(structural constituent of postsynaptic actin cytoskeleton)|go:"GO:0099184"(structural constituent of postsynaptic intermediate filament cytoskeleton)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|interpro:IPR027703|interpro:IPR039008|mint:Q16352	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:HXC2d0wajSa0s9r7b4qtpqi3g+s9606	rigid:DfGCuG52ClZhk6y1S6HgJ3Lj/d0	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q9UHF1	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-949532|ensembl:ENSP00000307843|ensembl:ENSP00000360763|ensembl:ENSP00000360764|ensembl:ENSP00000385639|uniprotkb:Q5M7Y5|uniprotkb:Q5VUD5|uniprotkb:Q96EG0|uniprotkb:B3KRP0|uniprotkb:M9VTX9	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:egfl7_human(display_long)|uniprotkb:Multiple epidermal growth factor-like domains protein 7(gene name synonym)|uniprotkb:Zneu1(gene name synonym)|uniprotkb:Vascular endothelial statin(gene name synonym)|uniprotkb:NOTCH4-like protein(gene name synonym)|uniprotkb:EGFL7(gene name)|psi-mi:EGFL7(display_short)|uniprotkb:MEGF7(gene name synonym)|uniprotkb:UNQ187/PRO1449(orf name)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510346|imex:IM-28561-25	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	ensembl:ENSG00000172889(gene)|ensembl:ENST00000308874(transcript)|ensembl:ENST00000371698(transcript)|ensembl:ENST00000371699(transcript)|ensembl:ENST00000406555(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001568"(blood vessel development)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0007155"(cell adhesion)|go:"GO:0009986"(cell surface)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0048856"(anatomical structure development)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011489(EMI)|interpro:IPR013111(EGF, extracellular)|interpro:IPR018097|mint:Q9UHF1|go:"GO:0005576"(extracellular region)|refseq:NP_057299.1|refseq:NP_958854.1|refseq:XP_011517066.1|refseq:XP_011517067.1|refseq:XP_011517068.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:HzaJXQm4JE8bXXE+/ugmqGjpjZA9606	rigid:poY2Gr1dj7XldlwP3yIvEAHwygA	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q13123	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-713456|uniprotkb:Q6IPD8|ensembl:ENSP00000396301	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:red_human(display_long)|uniprotkb:Protein RER(gene name synonym)|uniprotkb:IK factor(gene name synonym)|uniprotkb:Cytokine IK(gene name synonym)|uniprotkb:IK(gene name)|psi-mi:IK(display_short)|uniprotkb:RED(gene name synonym)|uniprotkb:RER(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510592|imex:IM-28561-241	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	ensembl:ENSG00000113141(gene)|ensembl:ENST00000417647(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000922"(spindle pole)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0016607"(nuclear speck)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0042802"(identical protein binding)|go:"GO:0071005"(U2-type precatalytic spliceosome)|interpro:IPR012492(RED-like, C-terminal)|interpro:IPR012916(RED-like, N-terminal)|interpro:IPR039896|mint:Q13123|rcsb pdb:5O9Z|rcsb pdb:6Q8I|refseq:NP_006074.2	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:EBUQl+Gj0ozHP85Uh4xc9q2Vr6Y9606	rigid:xONnrs4ydRwTWIH49mgvkbYFxSc	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:P04792	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-352682|uniprotkb:Q6FI47|uniprotkb:Q96C20|uniprotkb:Q96EI7|uniprotkb:Q9UC34|uniprotkb:Q9UC35|uniprotkb:Q9UC36|uniprotkb:Q9UC31|ensembl:ENSP00000248553|uniprotkb:B2R4N8	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:hspb1_human(display_long)|uniprotkb:HSPB1(gene name)|psi-mi:HSPB1(display_short)|uniprotkb:HSP27(gene name synonym)|uniprotkb:HSP28(gene name synonym)|uniprotkb:Heat shock 27 kDa protein(gene name synonym)|uniprotkb:Stress-responsive protein 27(gene name synonym)|uniprotkb:Estrogen-regulated 24 kDa protein(gene name synonym)|uniprotkb:28 kDa heat shock protein(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510585|imex:IM-28561-693	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_001531.1|ensembl:ENSG00000106211(gene)|ensembl:ENST00000248553(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008426"(protein kinase C inhibitor activity)|go:"GO:0009615"(response to virus)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0038033"(positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|interpro:IPR001436(Alpha crystallin/Heat shock protein)|interpro:IPR002068(Heat shock protein Hsp20)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037876|mint:P04792|rcsb pdb:2N3J|rcsb pdb:3Q9P|rcsb pdb:3Q9Q|rcsb pdb:4MJH|rcsb pdb:6DV5|rcsb pdb:6GJH|reactome:R-HSA-4420097|reactome:R-HSA-450408|reactome:R-HSA-5687128|reactome:R-HSA-9009391|dip:DIP-412N	-	-	crc64:1B4DC44A6F6606D5	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:vrDXIdzP30aHSDLHOh2D4x54eJY9606	rigid:W3U7eszj9DlhM4/AfhsFRyo4ppk	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:P00492	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-748210|uniprotkb:A6NHF0|uniprotkb:B2R8M9|ensembl:ENSP00000298556	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:hprt_human(display_long)|uniprotkb:HPRT1(gene name)|psi-mi:HPRT1(display_short)|uniprotkb:HPRT(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510576|imex:IM-28561-1119	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_000185.1|ensembl:ENSG00000165704(gene)|ensembl:ENST00000298556(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001913"(T cell mediated cytotoxicity)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004422"(hypoxanthine phosphoribosyltransferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006164"(purine nucleotide biosynthetic process)|go:"GO:0006166"(purine ribonucleoside salvage)|go:"GO:0006168"(adenine salvage)|go:"GO:0006178"(guanine salvage)|go:"GO:0007625"(grooming behavior)|go:"GO:0007626"(locomotory behavior)|go:"GO:0021756"(striatum development)|go:"GO:0021895"(cerebral cortex neuron differentiation)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0032263"(GMP salvage)|go:"GO:0032264"(IMP salvage)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043103"(hypoxanthine salvage)|go:"GO:0045964"(positive regulation of dopamine metabolic process)|go:"GO:0046038"(GMP catabolic process)|go:"GO:0046040"(IMP metabolic process)|go:"GO:0046100"(hypoxanthine metabolic process)|go:"GO:0046651"(lymphocyte proliferation)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0052657"(guanine phosphoribosyltransferase activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000836(Phosphoribosyltransferase)|interpro:IPR005904(Hypoxanthine phosphoribosyl transferase)|interpro:IPR029057|mint:P00492|rcsb pdb:1BZY|rcsb pdb:1D6N|rcsb pdb:1HMP|rcsb pdb:1Z7G|go:"GO:0048813"(dendrite morphogenesis)|rcsb pdb:2VFA|rcsb pdb:3GEP|rcsb pdb:3GGC|rcsb pdb:3GGJ|rcsb pdb:4IJQ|rcsb pdb:4KN6|rcsb pdb:4RAB|rcsb pdb:4RAC|rcsb pdb:4RAD|rcsb pdb:4RAN|rcsb pdb:4RAO|rcsb pdb:4RAQ|rcsb pdb:5BRN|rcsb pdb:5BSK|rcsb pdb:5HIA|rcsb pdb:5W8V|rcsb pdb:6BNJ|reactome:R-HSA-74217	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:w87Sv/qOAkHFqJm0vu0Ayqlz7TA9606	rigid:DD98EzZJFGMOdeUIbPT+kXc4Lq4	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q9NSC5	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-748420|uniprotkb:O14580|uniprotkb:O95350|uniprotkb:Q9NSB9|uniprotkb:Q9NSC0|intact:EBI-2557809|uniprotkb:E9PCW9|uniprotkb:Q9NSC1|intact:EBI-28972925|ensembl:ENSP00000376162|ensembl:ENSP00000439937|ensembl:ENSP00000446026|intact:EBI-10175777|uniprotkb:B2RA10	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:home3_human(display_long)|uniprotkb:HOMER3(gene name)|psi-mi:HOMER3(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510567|imex:IM-28561-1369	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	ensembl:ENST00000221222|ensembl:ENSP00000221222|ensembl:ENSP00000376162|ensembl:ENST00000433218|ensembl:ENSP00000396154|ensembl:ENSP00000439937|ensembl:ENSP00000446026|ensembl:ENST00000594439|ensembl:ENSP00000471835|refseq:XP_006723006.1|refseq:XP_006723007.1|refseq:NP_001139193.1|refseq:NP_001139194.1|refseq:NP_004829.3|refseq:NP_001139196.1|ensembl:ENSG00000051128(gene)|ensembl:ENST00000392351(transcript)|ensembl:ENST00000539827(transcript)|ensembl:ENST00000542541(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006605"(protein targeting)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030425"(dendrite)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0035256"(G protein-coupled glutamate receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:2001256"(regulation of store-operated calcium entry)|interpro:IPR000697(EVH1)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR044100|mint:Q9NSC5|rcsb pdb:2P8V|rcsb pdb:3CVF|reactome:R-HSA-6794361	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:U1y/y52nnf7zQUCNQlqk7JDgXi49606	rigid:NR7kl1GdUdoIpsHcNICZTeyAfYg	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q9NSB8	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-2126733|uniprotkb:O95269|uniprotkb:O95349|uniprotkb:Q9NSB6|uniprotkb:Q9NSB7|uniprotkb:Q9UNT7|ensembl:ENSP00000305632	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:home2_human(display_long)|uniprotkb:HOMER2(gene name)|psi-mi:HOMER2(display_short)|uniprotkb:Cupidin(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510560|imex:IM-28561-453	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_004830.2|refseq:NP_955362.1|ensembl:ENSG00000103942(gene)|ensembl:ENST00000304231(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030425"(dendrite)|go:"GO:0032426"(stereocilium tip)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0035256"(G protein-coupled glutamate receptor binding)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043229"(intracellular organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048875"(chemical homeostasis within a tissue)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2001256"(regulation of store-operated calcium entry)|interpro:IPR000697(EVH1)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR044100|mint:Q9NSB8|reactome:R-HSA-6794361	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:iM2wr76FuE6QvhrLNoYhLawa6CE9606	rigid:VRGePkRu98B9D6fDvxcMZkpJj/o	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q9BUJ2	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-1018153|uniprotkb:O76022|uniprotkb:Q6ZSZ0|uniprotkb:Q7L8P4|uniprotkb:Q8N6Z4|uniprotkb:Q96G37|uniprotkb:Q9HAL3|uniprotkb:Q9UG75|intact:EBI-3183399|intact:EBI-2339292|uniprotkb:B3KMW7|ensembl:ENSP00000375863|intact:EBI-2563529	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:hnrl1_human(display_long)|uniprotkb:E1BAP5(gene name synonym)|uniprotkb:HNRNPUL1(gene name)|psi-mi:HNRNPUL1(display_short)|uniprotkb:HNRPUL1(gene name synonym)|uniprotkb:Adenovirus early region 1B-associated protein 5(gene name synonym)|uniprotkb:E1B-55 kDa-associated protein 5(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510551|imex:IM-28561-899	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_008971.2|refseq:NP_653333.1|go:"GO:0009615"(response to virus)|go:"GO:0019899"(enzyme binding)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003034(DNA-binding SAP)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR027025|interpro:IPR027417|interpro:IPR035778|interpro:IPR036361|interpro:IPR043136|mint:Q9BUJ2|reactome:R-HSA-72163|ensembl:ENSG00000105323(gene)|ensembl:ENST00000392006(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006396"(RNA processing)|refseq:NP_001308140.1|refseq:NP_001308137.1|dip:DIP-39419N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:IahA7SVR1NmvldrWKQlAwApinQE9606	rigid:VYrbXLUpz7vRU26p7NlEosf4c+k	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:P52272	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-486809|uniprotkb:Q9Y492|uniprotkb:Q15584|uniprotkb:Q8WZ44|uniprotkb:Q96H56|uniprotkb:Q9BWL9|intact:EBI-28985795|ensembl:ENSP00000325376	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:hnrpm_human(display_long)|uniprotkb:HNRNPM(gene name)|psi-mi:HNRNPM(display_short)|uniprotkb:HNRPM(gene name synonym)|uniprotkb:NAGR1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510542|imex:IM-28561-897	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_005959.2|refseq:NP_112480.2|ensembl:ENSG00000099783(gene)|ensembl:ENST00000325495(transcript)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0016020"(membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0042382"(paraspeckles)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0071014"(post-mRNA release spliceosomal complex)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000815"(regulation of mRNA stability involved in response to oxidative stress)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR024666|interpro:IPR024667|interpro:IPR034990|interpro:IPR035979|mint:P52272|rcsb pdb:2DGV|rcsb pdb:2DH9|rcsb pdb:2DO0|rcsb pdb:2OT8|reactome:R-HSA-6803529|reactome:R-HSA-72163|reactome:R-HSA-72203|dip:DIP-29336N|ensembl:ENSP00000325376|ensembl:ENST00000348943|ensembl:ENSP00000325732	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:5FnCgrz0xltEkgw3yh70KP2jz5g9606	rigid:OBVUSYvDWiKxrwNzhthwxa3k4Wc	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:P55795	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-352823|ensembl:ENSP00000361927|uniprotkb:Q9HHA7|uniprotkb:A1L400	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:hnrh2_human(display_long)|uniprotkb:HNRNPH2(gene name)|psi-mi:HNRNPH2(display_short)|uniprotkb:FTP3(gene name synonym)|uniprotkb:HNRPH2(gene name synonym)|uniprotkb:Heterogeneous nuclear ribonucleoprotein H'(gene name synonym)|uniprotkb:FTP-3(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510533|imex:IM-28561-239	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	ensembl:ENSG00000126945(gene)|ensembl:ENST00000316594(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR012996(Zinc finger, CHHC-type)|interpro:IPR035979|mint:P55795|rcsb pdb:1WEZ|rcsb pdb:1WG5|rcsb pdb:6DG1|reactome:R-HSA-72163|reactome:R-HSA-72203|interpro:IPR000504(RNA recognition motif, RNP-1)|refseq:NP_001027565.1|refseq:NP_062543.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:811j5syFsbk/QSaZv/ag9QsFUEQ9606	rigid:L4yYA2Y6BIuhorIdJg0h5O6t1tM	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q9NP66	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-740641|ensembl:ENSP00000336856|ensembl:ENSP00000371133|uniprotkb:A6NHY3|uniprotkb:Q53G31|uniprotkb:Q9NSF6|uniprotkb:D3DW78	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:hm20a_human(display_long)|uniprotkb:HMG box-containing protein 20A(gene name synonym)|uniprotkb:HMG domain-containing protein HMGX1(gene name synonym)|uniprotkb:HMG20A(gene name)|psi-mi:HMG20A(display_short)|uniprotkb:HMGX1(gene name synonym)|uniprotkb:HMGXB1(gene name synonym)|uniprotkb:HMG domain-containing protein 1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510526|imex:IM-28561-451	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_060670.1|ensembl:ENSG00000140382(gene)|ensembl:ENST00000336216(transcript)|ensembl:ENST00000381714(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006325"(chromatin organization)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045665"(negative regulation of neuron differentiation)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR036910|mint:Q9NP66|refseq:NP_001291433.1|refseq:NP_001291434.1|refseq:XP_011519460.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:LhilayeP+xv97pbYzIA8yMvwUbc9606	rigid:M0MbQMtkzttYVjT/VuCqlY6rAb8	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q30154	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-2798348|uniprotkb:Q29788|uniprotkb:C7C4X3|uniprotkb:O00283|uniprotkb:O46700|uniprotkb:Q29787|uniprotkb:B2RBV6|uniprotkb:Q30126|uniprotkb:O00157|uniprotkb:Q29703|uniprotkb:Q9MY54|uniprotkb:Q7M2H9|uniprotkb:Q30150|uniprotkb:Q8HWS7|uniprotkb:Q6SJR2|uniprotkb:Q8WLR5|uniprotkb:Q9XRX6|uniprotkb:Q30199|ensembl:ENSP00000364114	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:drb5_human(display_long)|uniprotkb:DR beta-5(gene name synonym)|uniprotkb:DR2-beta-2(gene name synonym)|uniprotkb:Dw2(gene name synonym)|uniprotkb:MHC class II antigen DRB5(gene name synonym)|uniprotkb:HLA-DRB5(gene name)|psi-mi:HLA-DRB5(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510517|imex:IM-28561-691	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_002116.2|ensembl:ENSG00000198502(gene)|ensembl:ENST00000374975(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002504"(antigen processing and presentation of peptide or polysaccharide antigen via MHC class II)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR000353(MHC class II, beta chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|mint:Q30154|rcsb pdb:1FV1|rcsb pdb:1H15|rcsb pdb:1HQR|rcsb pdb:1ZGL|reactome:R-HSA-202424|reactome:R-HSA-202427|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-2132295|reactome:R-HSA-389948|reactome:R-HSA-877300	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:ipwOu43xHvM4TpqIDU/kbn8ZJbI9606	rigid:R2MJ9LY37wk5h9BZBl9VFTkgO00	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:P15822	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-722264|uniprotkb:Q14122|uniprotkb:Q5VW60|uniprotkb:B2RTU3|uniprotkb:Q5MPB1|ensembl:ENSP00000368698	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:zep1_human(display_long)|uniprotkb:Human immunodeficiency virus type I enhancer-binding protein 1(gene name synonym)|uniprotkb:Major histocompatibility complex-binding protein 1(gene name synonym)|uniprotkb:Positive regulatory domain II-binding factor 1(gene name synonym)|uniprotkb:HIVEP1(gene name)|psi-mi:HIVEP1(display_short)|uniprotkb:ZNF40(gene name synonym)|uniprotkb:Gate keeper of apoptosis-activating protein(gene name synonym)|uniprotkb:Cirhin interaction protein(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510508|imex:IM-28561-1601	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_002105.3|ensembl:ENSG00000095951(gene)|ensembl:ENST00000379388(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016604"(nuclear body)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR034729|interpro:IPR036236|mint:P15822|rcsb pdb:1BBO|rcsb pdb:3ZNF|rcsb pdb:4ZNF	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:rugwzqsTO0X8mJ5Zy3msTqc6dr09606	rigid:/sHgQG+IgNlI+JMnFAd/2MFW7pU	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:P60508	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-17973325|ensembl:ENSP00000420174|ensembl:ENSP00000444461	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:sycy2_human(display_long)|uniprotkb:Endogenous retrovirus group FRD member 1(gene name synonym)|uniprotkb:Envelope polyprotein(gene name synonym)|uniprotkb:HERV-FRD(gene name synonym)|uniprotkb:HERV-FRD_6p24.1 provirus ancestral Env polyprotein(gene name synonym)|uniprotkb:UNQ6191/PRO20218(orf name)|uniprotkb:ERVFRD-1(gene name)|psi-mi:ERVFRD-1(display_short)|uniprotkb:ERVFRDE1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510499|imex:IM-28561-33	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_997465.1|ensembl:ENSG00000244476(gene)|ensembl:ENST00000472091(transcript)|ensembl:ENST00000542862(transcript)|go:"GO:0000768"(syncytium formation by plasma membrane fusion)|go:"GO:0005886"(plasma membrane)|go:"GO:0006949"(syncytium formation)|go:"GO:0007520"(myoblast fusion)|go:"GO:0016021"(integral component of membrane)|interpro:IPR018154|mint:P60508|rcsb pdb:1Y4M|rcsb pdb:6RX3	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:nYg4GHUxFtjCBdhom5xW6dghANc9606	rigid:YOPkqRdWEkz5skvWlLxXOMnhBLI	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q4V328	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-717919|uniprotkb:A6NL78|uniprotkb:Q3MJ75|uniprotkb:Q4V327|uniprotkb:Q4V330|uniprotkb:Q5HYG1|uniprotkb:Q6N046|uniprotkb:Q96DH8|uniprotkb:Q9NQ43|uniprotkb:Q9ULQ3|ensembl:ENSP00000365606	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:grap1_human(display_long)|uniprotkb:GRIPAP1(gene name)|psi-mi:GRIPAP1(display_short)|uniprotkb:KIAA1167(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510492|imex:IM-28561-449	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_064522.3|ensembl:ENSG00000068400(gene)|ensembl:ENST00000376423(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0072562"(blood microparticle)|go:"GO:0098837"(postsynaptic recycling endosome)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098998"(extrinsic component of postsynaptic early endosome membrane)|go:"GO:0099152"(regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0099158"(regulation of recycling endosome localization within postsynapse)|go:"GO:1905244"(regulation of modification of synaptic structure)|interpro:IPR026204|mint:Q4V328|dip:DIP-47299N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:iIGfz5XvbexX4taRlMqWYsfAVBo9606	rigid:Yi9HwcfFKImilFbt9eL297ekWcU	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q9C0E4	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-949557|ensembl:ENSP00000478352|uniprotkb:Q8TEH9|uniprotkb:Q9H7H3|uniprotkb:A0A087WU38	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:grip2_human(display_long)|uniprotkb:GRIP2(gene name)|psi-mi:GRIP2(display_short)|uniprotkb:KIAA1719(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510485|imex:IM-28561-689	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_001073892.3|ensembl:ENSG00000144596(gene)|ensembl:ENST00000621039(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030425"(dendrite)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR030029|interpro:IPR036034|interpro:IPR041489|interpro:IPR043545|mint:Q9C0E4|rcsb pdb:1V62|rcsb pdb:1X5R|reactome:R-HSA-416993	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:lTPxa2HShPc1AvYjV76GCgEl1QA9606	rigid:g8iXUiS7C4RjZ8ZYb95LDRtxeIM	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q9Y3R0	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-5349621|uniprotkb:C9JT59|uniprotkb:Q1RLM0|ensembl:ENSP00000352780	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:grip1_human(display_long)|uniprotkb:GRIP1(gene name)|psi-mi:GRIP1(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510476|imex:IM-28561-1117	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:XP_011536395.1|refseq:NP_001171545.1|refseq:NP_066973.2|ensembl:ENSG00000155974(gene)|ensembl:ENST00000359742(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016358"(dendrite development)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030425"(dendrite)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0045121"(membrane raft)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|go:"GO:0150012"(positive regulation of neuron projection arborization)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR030026|interpro:IPR036034|interpro:IPR041489|interpro:IPR043545|mint:Q9Y3R0|rcsb pdb:2JIL|reactome:R-HSA-416993	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:BBMxSfND5Mr47/EoX8y0RmCQjCc9606	rigid:oiJT5qol5XfUpUKnTBDJtRCBZBA	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P81274	uniprotkb:P51114	intact:EBI-618655|uniprotkb:Q5T1N8|ensembl:ENSP00000264126|ensembl:ENSP00000385510|ensembl:ENSP00000392138|ensembl:ENSP00000496104|ensembl:ENSP00000496756|ensembl:ENSP00000502178|uniprotkb:Q8N0Z5|uniprotkb:Q6IBL7	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	psi-mi:gpsm2_human(display_long)|uniprotkb:GPSM2(gene name)|psi-mi:GPSM2(display_short)|uniprotkb:LGN(gene name synonym)|uniprotkb:Mosaic protein LGN(gene name synonym)	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510467|imex:IM-28561-1115	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000121957(gene)|ensembl:ENST00000264126(transcript)|ensembl:ENST00000406462(transcript)|ensembl:ENST00000446797(transcript)|ensembl:ENST00000642355(transcript)|ensembl:ENST00000645164(transcript)|ensembl:ENST00000676184(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000166"(nucleotide binding)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031291"(Ran protein signal transduction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0051301"(cell division)|go:"GO:0051661"(maintenance of centrosome location)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0070840"(dynein complex binding)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0097575"(lateral cell cortex)|go:"GO:0099738"(cell cortex region)|go:"GO:1904778"(positive regulation of protein localization to cell cortex)|go:"GO:1905832"(positive regulation of spindle assembly)|interpro:IPR003109(GoLoco)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|mint:P81274|rcsb pdb:3SF4|rcsb pdb:4WND|rcsb pdb:4WNE|rcsb pdb:4WNF|rcsb pdb:4WNG|rcsb pdb:5A6C|rcsb pdb:6HC2|reactome:R-HSA-418594|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0007052"(mitotic spindle organization)|refseq:NP_037428.3|refseq:NP_001307967.1|refseq:NP_001307968.1|refseq:XP_011539603.1|refseq:XP_011539604.1|refseq:XP_016856586.1|refseq:XP_016856587.1|dip:DIP-399N	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:qQOgAYWYhHlMg4d8HsqCxcNqnNg9606	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rigid:2cDpHTl5qdjRK61Hce7mGmdqq2g	false	-	sufficient binding region:215-363	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q08378	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-355782|uniprotkb:O43241|uniprotkb:Q6P9C7|uniprotkb:Q86XW3|uniprotkb:Q8TDA9|uniprotkb:Q8WZA3|uniprotkb:A5PKX6|intact:EBI-28985028|ensembl:ENSP00000204726|ensembl:ENSP00000410378	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:goga3_human(display_long)|uniprotkb:GOLGA3(gene name)|psi-mi:GOLGA3(display_short)|uniprotkb:Golgin-160(gene name synonym)|uniprotkb:Golgi complex-associated protein of 170 kDa(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510460|imex:IM-28561-1367	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_001166028.1|refseq:NP_005886.2|ensembl:ENSP00000204726|ensembl:ENSP00000410378|ensembl:ENST00000456883|ensembl:ENSP00000409303|ensembl:ENST00000545875|ensembl:ENSP00000442603|ensembl:ENSG00000090615(gene)|ensembl:ENST00000204726(transcript)|ensembl:ENST00000450791(transcript)|go:"GO:0045296"(cadherin binding)|go:"GO:0090498"(extrinsic component of Golgi membrane)|interpro:IPR033288|mint:Q08378|go:"GO:0000139"(Golgi membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|reactome:R-HSA-9696270|go:"GO:0005829"(cytosol)|go:"GO:0007283"(spermatogenesis)|go:"GO:0016020"(membrane)|go:"GO:0032580"(Golgi cisterna membrane)|refseq:XP_006719799.1|refseq:XP_006719800.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:7AjSzX3sUzfKpZkvdKDM0L//zYM9606	rigid:gTQaCdig/8h0jKeU6hfDE94VrXU	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q08379	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-618309|intact:EBI-28970132|ensembl:ENSP00000478799|uniprotkb:Q6GRM9|uniprotkb:Q9BRB0|uniprotkb:Q9NYF9|uniprotkb:A0A0C4DGS5|intact:EBI-11522202	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:goga2_human(display_long)|uniprotkb:GOLGA2(gene name)|psi-mi:GOLGA2(display_short)|uniprotkb:130 kDa cis-Golgi matrix protein(gene name synonym)|uniprotkb:GM130 autoantigen(gene name synonym)|uniprotkb:Golgin-95(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510451|imex:IM-28561-687	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	ensembl:ENSG00000167110(gene)|ensembl:ENST00000611957(transcript)|go:"GO:0000137"(Golgi cis cisterna)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000922"(spindle pole)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005874"(microtubule)|go:"GO:0006486"(protein glycosylation)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007030"(Golgi organization)|go:"GO:0007098"(centrosome cycle)|go:"GO:0008017"(microtubule binding)|go:"GO:0008356"(asymmetric cell division)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0015031"(protein transport)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0060050"(positive regulation of protein glycosylation)|go:"GO:0061676"(importin-alpha family protein binding)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090161"(Golgi ribbon formation)|go:"GO:0090166"(Golgi disassembly)|go:"GO:0090306"(meiotic spindle assembly)|go:"GO:0090307"(mitotic spindle assembly)|interpro:IPR024858|interpro:IPR043937|interpro:IPR043976|mint:Q08379|rcsb pdb:4REY|rcsb pdb:6IW8|rcsb pdb:6IWA|rcsb pdb:6K06|reactome:R-HSA-162658|reactome:R-HSA-204005|reactome:R-HSA-6807878|reactome:R-HSA-8862803|refseq:NP_004477.3|ensembl:ENSP00000478799|dip:DIP-34271N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:vIlRg4sJ2oBiARNnyerGMaVr5ZU9606	rigid:nPqzW8SPW29k9ap6w0ouybO3Enw	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:P14136	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-744302|uniprotkb:Q53H98|uniprotkb:Q5D055|uniprotkb:Q6ZQS3|uniprotkb:Q7Z5J6|uniprotkb:Q7Z5J7|uniprotkb:Q96KS4|uniprotkb:Q96P18|uniprotkb:Q9UFD0|uniprotkb:B2RD44|uniprotkb:D3DX59|intact:EBI-3909365|uniprotkb:E9PAX3|ensembl:ENSP00000466598|uniprotkb:A7REI1	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:gfap_human(display_long)|uniprotkb:GFAP(gene name)|psi-mi:GFAP(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510442|imex:IM-28561-1365	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_001124491.1|refseq:NP_001229305.1|refseq:NP_002046.1|ensembl:ENSG00000131095(gene)|ensembl:ENST00000588735(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0009611"(response to wounding)|go:"GO:0010467"(gene expression)|go:"GO:0010625"(positive regulation of Schwann cell proliferation)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014002"(astrocyte development)|go:"GO:0019900"(kinase binding)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031102"(neuron projection regeneration)|go:"GO:0042802"(identical protein binding)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0044297"(cell body)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0051580"(regulation of neurotransmitter uptake)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0070779"(D-aspartate import across plasma membrane)|go:"GO:0097450"(astrocyte end-foot)|go:"GO:0098574"(cytoplasmic side of lysosomal membrane)|go:"GO:1904714"(regulation of chaperone-mediated autophagy)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|interpro:IPR027701|interpro:IPR039008|mint:P14136|rcsb pdb:6A9P|reactome:R-HSA-1251985|reactome:R-HSA-9613829	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:Pz4JW0WjMjBYILTDSX9jUmMqWhg9606	rigid:i84whaA9SN2wvJiM+ZfQsiNXjMI	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:P51116	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510435|imex:IM-28561-237	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606	rigid:CVbfRJhrMiOqjqPnlBzhR25HWME	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:P02794	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-713259|uniprotkb:Q3KRA8|uniprotkb:Q3SWW1|ensembl:ENSP00000273550|ensembl:ENSP00000484477|uniprotkb:B3KNR5	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:frih_human(display_long)|uniprotkb:Cell proliferation-inducing gene 15 protein(gene name synonym)|uniprotkb:FTH1(gene name)|psi-mi:FTH1(display_short)|uniprotkb:FTH(gene name synonym)|uniprotkb:FTHL6(gene name synonym)|uniprotkb:PIG15(orf name)|uniprotkb:OK/SW-cl.84(orf name)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510426|imex:IM-28561-447	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_002023.2|ensembl:ENSG00000167996(gene)|ensembl:ENST00000273550(transcript)|ensembl:ENST00000620041(transcript)|go:"GO:0004322"(ferroxidase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006826"(iron ion transport)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0006880"(intracellular sequestering of iron ion)|go:"GO:0006955"(immune response)|go:"GO:0008043"(intracellular ferritin complex)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008199"(ferric iron binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0044754"(autolysosome)|mint:P02794|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:1FHA|rcsb pdb:2CEI|rcsb pdb:2CHI|rcsb pdb:2CIH|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR001519(Ferritin, N-terminal)|interpro:IPR008331(Ferritin and Dps)|interpro:IPR009040(Ferritin-like)|interpro:IPR009078(Ferritin/ribonucleotide reductase-like)|interpro:IPR012347(Ferritin-related)|interpro:IPR014034(Ferritin, conserved site)|rcsb pdb:2CLU|rcsb pdb:2CN6|rcsb pdb:2CN7|rcsb pdb:2FHA|rcsb pdb:2IU2|rcsb pdb:2Z6M|rcsb pdb:3AJO|rcsb pdb:3AJP|rcsb pdb:3AJQ|rcsb pdb:3ERZ|rcsb pdb:3ES3|rcsb pdb:4DYX|rcsb pdb:4DYY|rcsb pdb:4DYZ|rcsb pdb:4Y08|rcsb pdb:4YKH|rcsb pdb:4ZJK|rcsb pdb:5CMQ|rcsb pdb:5CMR|rcsb pdb:5GN8|rcsb pdb:5GOU|rcsb pdb:5JKK|rcsb pdb:5JKL|rcsb pdb:5JKM|rcsb pdb:5N26|rcsb pdb:5N27|rcsb pdb:5UP7|rcsb pdb:5UP8|rcsb pdb:5UP9|rcsb pdb:5VTD|rcsb pdb:5XB1|rcsb pdb:5YI5|rcsb pdb:5ZND|rcsb pdb:6B8F|rcsb pdb:6B8G|rcsb pdb:4DZ0|rcsb pdb:6FTV|rcsb pdb:6GSR|rcsb pdb:6H5I|rcsb pdb:6H6T|rcsb pdb:6H6U|rcsb pdb:6IPC|rcsb pdb:6IPO|rcsb pdb:6IPP|rcsb pdb:6IPQ|rcsb pdb:6J4A|rcsb pdb:6J7G|rcsb pdb:6JOB|rcsb pdb:6JPS|rcsb pdb:6KE2|rcsb pdb:6KE4|rcsb pdb:4OYN|rcsb pdb:6M52|rcsb pdb:6M54|rcsb pdb:6WYF|rcsb pdb:6WYG|rcsb pdb:6WYH|rcsb pdb:6Z6U|rcsb pdb:6Z9E|rcsb pdb:6Z9F|rcsb pdb:7A6A|rcsb pdb:7A6B|rcsb pdb:7CK8|rcsb pdb:7CK9|rcsb pdb:7JGK|rcsb pdb:7JGL|rcsb pdb:7JGM|rcsb pdb:7JGN|rcsb pdb:7JGO|rcsb pdb:7JGP|rcsb pdb:7JGQ|rcsb pdb:7K26|rcsb pdb:7K3V|rcsb pdb:7K3W|reactome:R-HSA-3000480|reactome:R-HSA-432722|reactome:R-HSA-6798695|reactome:R-HSA-917937|dip:DIP-38301N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:TchHgRpv+inA8BQ5i0OHaa267tQ9606	rigid:s2+qHQ1HmIJLRd0GxWd0bzwKa/s	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:O75369	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-352089|intact:EBI-1754974|uniprotkb:Q13706|uniprotkb:Q59EC2|uniprotkb:Q6MZJ1|uniprotkb:Q8WXS9|uniprotkb:Q8WXT0|uniprotkb:Q8WXT1|uniprotkb:Q8WXT2|uniprotkb:Q9NRB5|uniprotkb:B2ZZ84|uniprotkb:Q9NT26|uniprotkb:Q9UEV9|intact:EBI-1960054|uniprotkb:C9JKE6|uniprotkb:B2ZZ85|uniprotkb:C9JMC4|ensembl:ENSP00000295956|uniprotkb:B2ZZ83|uniprotkb:Q60FE7|uniprotkb:Q8WXT3	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:flnb_human(display_long)|uniprotkb:FLNB(gene name)|psi-mi:FLNB(display_short)|uniprotkb:FLN1L(gene name synonym)|uniprotkb:FLN3(gene name synonym)|uniprotkb:TABP(gene name synonym)|uniprotkb:TAP(gene name synonym)|uniprotkb:Beta-filamin(gene name synonym)|uniprotkb:Actin-binding-like protein(gene name synonym)|uniprotkb:Thyroid autoantigen(gene name synonym)|uniprotkb:Truncated actin-binding protein(gene name synonym)|uniprotkb:ABP-280 homolog(gene name synonym)|uniprotkb:ABP-278(gene name synonym)|uniprotkb:Filamin-3(gene name synonym)|uniprotkb:Filamin homolog 1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510419|imex:IM-28561-235	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_001157791.1|refseq:NP_001448.2|go:"GO:0003334"(keratinocyte development)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007165"(signal transduction)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045296"(cadherin binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0051015"(actin filament binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071346"(cellular response to interferon-gamma)|interpro:IPR001298(Filamin/ABP280 repeat)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR029874|interpro:IPR036872|interpro:IPR044801|mint:O75369|rcsb pdb:2DI8|rcsb pdb:2DI9|rcsb pdb:2DIA|rcsb pdb:2DIB|rcsb pdb:2DIC|rcsb pdb:2DJ4|rcsb pdb:2DLG|rcsb pdb:2DMB|rcsb pdb:2DMC|rcsb pdb:2E9I|rcsb pdb:2E9J|rcsb pdb:2EE6|rcsb pdb:2EE9|rcsb pdb:2EEA|rcsb pdb:2EEB|rcsb pdb:2EEC|rcsb pdb:2EED|rcsb pdb:2WA5|rcsb pdb:2WA6|rcsb pdb:2WA7|rcsb pdb:3FER|rcsb pdb:4B7L|rcsb pdb:5DCP|reactome:R-HSA-1169408|ensembl:ENSG00000136068(gene)|ensembl:ENST00000295956(transcript)|go:"GO:0001725"(stress fiber)|refseq:NP_001157789.1|refseq:NP_001157790.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:lsf6C/Vg0io7UhUi1Kapgwp0p5E9606	rigid:fq9V6PEYDdT7XQ42OyN7dRCp/+g	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:P21333	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-350432|uniprotkb:Q8NF52|intact:EBI-1103234|ensembl:ENSP00000358866|uniprotkb:Q5HY53|uniprotkb:Q5HY55|uniprotkb:E9KL45	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:flna_human(display_long)|uniprotkb:FLNA(gene name)|psi-mi:FLNA(display_short)|uniprotkb:FLN(gene name synonym)|uniprotkb:FLN1(gene name synonym)|uniprotkb:Alpha-filamin(gene name synonym)|uniprotkb:Filamin-1(gene name synonym)|uniprotkb:Endothelial actin-binding protein(gene name synonym)|uniprotkb:Actin-binding protein 280(gene name synonym)|uniprotkb:Non-muscle filamin(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510412|imex:IM-28561-895	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	go:"GO:0007195"(adenylate cyclase-inhibiting dopamine receptor signaling pathway)|go:"GO:1902396"(protein localization to bicellular tight junction)|refseq:NP_001104026.1|refseq:NP_001447.2|ensembl:ENSG00000196924(gene)|ensembl:ENST00000369850(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048680"(positive regulation of axon regeneration)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051015"(actin filament binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0051764"(actin crosslink formation)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090042"(tubulin deacetylation)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0097368"(establishment of Sertoli cell barrier)|go:"GO:0097440"(apical dendrite)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901381"(positive regulation of potassium ion transmembrane transport)|go:"GO:0046332"(SMAD binding)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016479"(negative regulation of transcription by RNA polymerase I)|go:"GO:0019900"(kinase binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0021943"(formation of radial glial scaffolds)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030018"(Z disc)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031523"(Myb complex)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031852"(mu-type opioid receptor binding)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0032432"(actin filament bundle)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034988"(Fc-gamma receptor I complex binding)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043113"(receptor clustering)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045296"(cadherin binding)|reactome:R-HSA-114608|reactome:R-HSA-430116|reactome:R-HSA-446353|reactome:R-HSA-5627123|reactome:R-HSA-8983711|rcsb pdb:6EW1|go:"GO:1905031"(regulation of membrane repolarization during cardiac muscle cell action potential)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2001046"(positive regulation of integrin-mediated signaling pathway)|go:"GO:2001224"(positive regulation of neuron migration)|interpro:IPR001298(Filamin/ABP280 repeat)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR036872|interpro:IPR044801|mint:P21333|rcsb pdb:2AAV|rcsb pdb:2BP3|rcsb pdb:2BRQ|rcsb pdb:2J3S|rcsb pdb:2JF1|rcsb pdb:2K3T|rcsb pdb:2K7P|rcsb pdb:2K7Q|rcsb pdb:2MTP|rcsb pdb:2W0P|rcsb pdb:2WFN|rcsb pdb:3CNK|rcsb pdb:3HOC|rcsb pdb:3HOP|rcsb pdb:3HOR|rcsb pdb:3ISW|rcsb pdb:3RGH|rcsb pdb:4M9P|rcsb pdb:4P3W|rcsb pdb:5XR1|rcsb pdb:6D8C|go:"GO:1905000"(regulation of membrane repolarization during atrial cardiac muscle cell action potential)|dip:DIP-1136N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:ZxGK5OSMy8cNsyt7Ax2KXb8bn9M9606	rigid:4Js/Y6p3ViF+6lq6aX6PnlAddrM	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q8NFF5	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-742815|uniprotkb:Q8N5J1|uniprotkb:Q8N686|uniprotkb:Q8WU93|uniprotkb:Q8WUJ4|uniprotkb:Q96CR8|uniprotkb:Q99764|uniprotkb:Q9HBN6|ensembl:ENSP00000292180	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:fad1_human(display_long)|uniprotkb:FMN adenylyltransferase(gene name synonym)|uniprotkb:FAD pyrophosphorylase(gene name synonym)|uniprotkb:Flavin adenine dinucleotide synthase(gene name synonym)|uniprotkb:FLAD1(gene name)|psi-mi:FLAD1(display_short)|uniprotkb:PP591(orf name)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510403|imex:IM-28561-685	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_001171820.1|refseq:NP_001171821.1|refseq:NP_079483.3|refseq:NP_958800.1|ensembl:ENSG00000160688(gene)|ensembl:ENST00000292180(transcript)|go:"GO:0003919"(FMN adenylyltransferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006747"(FAD biosynthetic process)|go:"GO:0006771"(riboflavin metabolic process)|go:"GO:0042802"(identical protein binding)|interpro:IPR001453(Molybdopterin binding)|interpro:IPR002500(Phosphoadenosine phosphosulphate reductase)|interpro:IPR012183(FAD synthetase, molybdopterin binding)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR036425|mint:Q8NFF5|reactome:R-HSA-196843	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:XIktrF0PkC+W6/1cHF4l/WWtGUs9606	rigid:S2RPMiC41IJUuEAuGVMnOZLeVs4	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:P23142	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-726652|uniprotkb:P23143|uniprotkb:P23144|uniprotkb:P37888|uniprotkb:Q5TIC4|uniprotkb:Q8TBH8|uniprotkb:Q9HBQ5|uniprotkb:Q9UC21|uniprotkb:Q9UGR4|uniprotkb:Q9UH41|uniprotkb:B0QY42|intact:EBI-2562209|ensembl:ENSP00000331544|uniprotkb:B1AHL4	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:fbln1_human(display_long)|uniprotkb:FBLN1(gene name)|psi-mi:FBLN1(display_short)|uniprotkb:PP213(orf name)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510394|imex:IM-28561-31	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_001987.2|refseq:NP_006476.2|refseq:NP_006477.2|refseq:NP_006478.2|ensembl:ENSG00000077942(gene)|ensembl:ENST00000327858(transcript)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001968"(fibronectin binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007566"(embryo implantation)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070051"(fibrinogen binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071635"(negative regulation of transforming growth factor beta production)|go:"GO:0071953"(elastic fiber)|go:"GO:0072378"(blood coagulation, fibrin clot formation)|go:"GO:1900025"(negative regulation of substrate adhesion-dependent cell spreading)|go:"GO:1904188"(negative regulation of transformation of host cell by virus)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000647"(negative regulation of stem cell proliferation)|interpro:IPR000020(Anaphylatoxin/fibulin)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR017048(Fibulin-1)|interpro:IPR018097|interpro:IPR026823|mint:P23142|reactome:R-HSA-2129379|go:"GO:0005201"(extracellular matrix structural constituent)	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:a47ZJLXWeghGIY9xJTQI7VujuMk9606	rigid:HvwQgIGLoBKZwPo2sgpjrOLdmKQ	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q9H1Q7	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-748452|uniprotkb:Q5JUA5|uniprotkb:Q5JUA6|uniprotkb:Q6PK19|uniprotkb:Q86WF5|uniprotkb:Q96CG7|uniprotkb:Q9H1Q6|uniprotkb:Q9H6D1|ensembl:ENSP00000353868	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:ped1a_human(display_long)|uniprotkb:PCED1A(gene name)|psi-mi:PCED1A(display_short)|uniprotkb:C20orf81(gene name synonym)|uniprotkb:FAM113A(gene name synonym)|uniprotkb:Protein FAM113A(gene name synonym)|uniprotkb:Sarcoma antigen NY-SAR-23(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510385|imex:IM-28561-233	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_073597.2|refseq:NP_001258097.1|refseq:XP_005260861.1|refseq:XP_005260862.1|ensembl:ENSG00000132635(gene)|ensembl:ENST00000360652(transcript)|interpro:IPR026057|mint:Q9H1Q7	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:L1RRthUFVoaARhQE6LnQV1QLqLk9606	rigid:a/5Ck3ZcbXS4fCBato0WJOe1YE8	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q9UI08	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-346653|uniprotkb:O95884|uniprotkb:Q7Z522|uniprotkb:Q8TBV1|uniprotkb:Q9UF25|uniprotkb:A8K105|uniprotkb:Q9UIC2|uniprotkb:B7Z3I5|ensembl:ENSP00000384720	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:evl_human(display_long)|uniprotkb:EVL(gene name)|psi-mi:EVL(display_short)|uniprotkb:RNB6(gene name synonym)|uniprotkb:Ena/vasodilator-stimulated phosphoprotein-like(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510378|imex:IM-28561-893	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_057421.1|refseq:NP_001317150.1|ensembl:ENSG00000196405(gene)|ensembl:ENST00000402714(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010633"(negative regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0045010"(actin nucleation)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:1900028"(negative regulation of ruffle assembly)|interpro:IPR000697(EVH1)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014885(VASP tetramerisation)|interpro:IPR017354(Vasodilator-stimulated phosphoprotein)|interpro:IPR034319|interpro:IPR038023|mint:Q9UI08|reactome:R-HSA-202433|reactome:R-HSA-376176|reactome:R-HSA-5663220	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:ZYA6pfvqC68sm/0egUg4hBif/Pc9606	rigid:TwjhvJVQGe2ZLZkcota1KlJtOCo	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:P06733	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-353877|uniprotkb:P22712|uniprotkb:Q16704|uniprotkb:Q4TUS4|uniprotkb:Q658M5|uniprotkb:Q6GMP2|uniprotkb:Q71V37|uniprotkb:Q7Z3V6|uniprotkb:Q8WU71|uniprotkb:Q96GV1|uniprotkb:Q9BT62|uniprotkb:Q9UM55|ensembl:ENSP00000234590|uniprotkb:B2RD59|uniprotkb:Q53FT9|uniprotkb:Q53HR3|uniprotkb:Q9UCH6	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:enoa_human(display_long)|uniprotkb:ENO1(gene name)|psi-mi:ENO1(display_short)|uniprotkb:ENO1L1(gene name synonym)|uniprotkb:MBPB1(gene name synonym)|uniprotkb:MPB1(gene name synonym)|uniprotkb:2-phospho-D-glycerate hydro-lyase(gene name synonym)|uniprotkb:Non-neural enolase(gene name synonym)|uniprotkb:Enolase 1(gene name synonym)|uniprotkb:Phosphopyruvate hydratase(gene name synonym)|uniprotkb:C-myc promoter-binding protein(gene name synonym)|uniprotkb:MBP-1(gene name synonym)|uniprotkb:MPB-1(gene name synonym)|uniprotkb:Plasminogen-binding protein(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510369|imex:IM-28561-29	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_001188412.1|refseq:NP_001419.1|ensembl:ENSG00000074800(gene)|ensembl:ENST00000234590(transcript)|go:"GO:0000015"(phosphopyruvate hydratase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003723"(RNA binding)|go:"GO:0004634"(phosphopyruvate hydratase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006096"(glycolytic process)|go:"GO:0009615"(response to virus)|go:"GO:0009986"(cell surface)|go:"GO:0010756"(positive regulation of plasminogen activation)|go:"GO:0016020"(membrane)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031430"(M band)|go:"GO:0032889"(regulation of vacuole fusion, non-autophagic)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045933"(positive regulation of muscle contraction)|go:"GO:0051020"(GTPase binding)|go:"GO:0061621"(canonical glycolysis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0099738"(cell cortex region)|go:"GO:1903298"(negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR000941(Enolase)|interpro:IPR020809|interpro:IPR020810|interpro:IPR020811|interpro:IPR029017|interpro:IPR036849|mint:P06733|rcsb pdb:2PSN|rcsb pdb:3B97|rcsb pdb:5JLZ|rcsb pdb:5LAX|rcsb pdb:5NI9|rcsb pdb:5NIG|rcsb pdb:5OCK|reactome:R-HSA-70171|reactome:R-HSA-70263|reactome:R-HSA-9636667	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:RmP7cr55H8ylcgBOEyivwljIE+09606	rigid:/IYrPNrZZwfbKwilX+V7/xR6YU0	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:O00423	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-751327|uniprotkb:Q86U15|uniprotkb:Q8N536|uniprotkb:Q8N5C4|uniprotkb:Q8WWL6|ensembl:ENSP00000262233	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:emal1_human(display_long)|uniprotkb:EML1(gene name)|psi-mi:EML1(display_short)|uniprotkb:EMAP1(gene name synonym)|uniprotkb:EMAPL(gene name synonym)|uniprotkb:EMAPL1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510362|imex:IM-28561-683	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_001008707.1|refseq:NP_004425.2|ensembl:ENSG00000066629(gene)|ensembl:ENST00000262233(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0007420"(brain development)|go:"GO:0008017"(microtubule binding)|go:"GO:0015631"(tubulin binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:1990023"(mitotic spindle midzone)|interpro:IPR001680(WD40 repeat)|interpro:IPR005108(HELP)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|mint:O00423|rcsb pdb:4CI8	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:hfGdCoFa3Miii6W/ozQuZ2cFiHs9606	rigid:ZFEkXm6LZKILLXJex1ZqwAFPvGk	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q14152	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-366617|uniprotkb:O00653|uniprotkb:Q15778|uniprotkb:B1AMV5|intact:EBI-28978176|ensembl:ENSP00000358140|ensembl:ENSP00000438178|uniprotkb:B4DYS1|uniprotkb:F5H335	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:eif3a_human(display_long)|uniprotkb:EIF3A(gene name)|psi-mi:EIF3A(display_short)|uniprotkb:KIAA0139(gene name synonym)|uniprotkb:EIF3S10(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 10(gene name synonym)|uniprotkb:eIF-3-theta(gene name synonym)|uniprotkb:eIF3 p167(gene name synonym)|uniprotkb:eIF3 p180(gene name synonym)|uniprotkb:eIF3 p185(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510355|imex:IM-28561-27	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_003741.1|ensembl:ENSP00000358140|ensembl:ENSP00000438178|ensembl:ENSG00000107581(gene)|ensembl:ENST00000369144(transcript)|ensembl:ENST00000541549(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0002188"(translation reinitiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0005874"(microtubule)|go:"GO:0006413"(translational initiation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0043614"(multi-eIF complex)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071540"(eukaryotic translation initiation factor 3 complex, eIF3e)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0075522"(IRES-dependent viral translational initiation)|go:"GO:0075525"(viral translational termination-reinitiation)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR027512|mint:Q14152|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6YBT|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-31114N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:COyPBU7e0SUL3BiZY7NQuUkmxns9606	rigid:2UdwpvwrpXorvLNjwTqCyOa7Y1k	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:P12268	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-353389|uniprotkb:Q6LEF3|ensembl:ENSP00000321584	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:imdh2_human(display_long)|uniprotkb:IMPDH2(gene name)|psi-mi:IMPDH2(display_short)|uniprotkb:IMPD2(gene name synonym)|uniprotkb:Inosine-5'-monophosphate dehydrogenase type II(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510599|imex:IM-28561-243	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_000875.2|ensembl:ENSG00000178035(gene)|ensembl:ENST00000326739(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003938"(IMP dehydrogenase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006177"(GMP biosynthetic process)|go:"GO:0006183"(GTP biosynthetic process)|go:"GO:0007623"(circadian rhythm)|go:"GO:0016020"(membrane)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0046651"(lymphocyte proliferation)|go:"GO:0046872"(metal ion binding)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000644(Cystathionine beta-synthase, core)|interpro:IPR001093(IMP dehydrogenase/GMP reductase)|interpro:IPR005990(IMP dehydrogenase)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR015875(IMP dehydrogenase / GMP reductase, conserved site)|mint:P12268|rcsb pdb:1B3O|rcsb pdb:1NF7|rcsb pdb:1NFB|rcsb pdb:6I0M|rcsb pdb:6I0O|rcsb pdb:6U8E|rcsb pdb:6U8N|rcsb pdb:6U8R|rcsb pdb:6U8S|rcsb pdb:6U9O|rcsb pdb:6UA2|rcsb pdb:6UA4|rcsb pdb:6UA5|rcsb pdb:6UAJ|rcsb pdb:6UC2|rcsb pdb:6UDO|rcsb pdb:6UDP|rcsb pdb:6UDQ|reactome:R-HSA-6798695|reactome:R-HSA-73817|reactome:R-HSA-9679191	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:qGPwBxhEgtYik3OetHZbpyktoLE9606	rigid:m/x2t0lt0NPGxqCY2+5fo9DWokg	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q9ULV0	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-311356|uniprotkb:B0I1R3|uniprotkb:Q0P656|uniprotkb:Q9H6Y6|intact:EBI-28979562|ensembl:ENSP00000285039	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:myo5b_human(display_long)|uniprotkb:MYO5B(gene name)|psi-mi:MYO5B(display_short)|uniprotkb:KIAA1119(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510842|imex:IM-28561-45	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	ensembl:ENSP00000285039|ensembl:ENST00000592688|ensembl:ENSP00000466368|ensembl:ENSG00000167306(gene)|ensembl:ENST00000285039(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0003091"(renal water homeostasis)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007015"(actin filament organization)|go:"GO:0015031"(protein transport)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0016459"(myosin complex)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031982"(vesicle)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045179"(apical cortex)|go:"GO:0051015"(actin filament binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR002710(Dilute)|interpro:IPR004009(Myosin, N-terminal, SH3-like)|interpro:IPR027417|interpro:IPR036103|interpro:IPR036961|interpro:IPR037990|mint:Q9ULV0|rcsb pdb:4J5M|rcsb pdb:4LNZ|rcsb pdb:4LWZ|rcsb pdb:4LX0|reactome:R-HSA-432040|refseq:NP_001073936.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:p6fM9FBgui27LRlshWAjPe47Ftc9606	rigid:THrT5C5TnAr7SVT6aCpQZRyobZ8	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q92952	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-1748210|uniprotkb:Q5KR10|uniprotkb:Q6DJU4|ensembl:ENSP00000476519|ensembl:ENSP00000507021	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:kcnn1_human(display_long)|uniprotkb:KCNN1(gene name)|psi-mi:KCNN1(display_short)|uniprotkb:SK(gene name synonym)|uniprotkb:KCa2.1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510629|imex:IM-28561-37	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_002239.2|ensembl:ENSG00000105642(gene)|ensembl:ENST00000222249(transcript)|ensembl:ENST00000684775(transcript)|go:"GO:0005242"(inward rectifier potassium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006811"(ion transport)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016286"(small conductance calcium-activated potassium channel activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0071805"(potassium ion transmembrane transport)|interpro:IPR004178(Calmodulin-binding)|interpro:IPR013099(Ion transport 2)|interpro:IPR015449(Potassium channel, calcium-activated, SK)|interpro:IPR036122|mint:Q92952|reactome:R-HSA-1296052	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:RIHdyjX19x3KPYbf2JV2Fwcp+W49606	rigid:nGA1JsrXuvoqMA9+1jxrEgMRoB4	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q719H9	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-9027502|uniprotkb:A8K1F5|ensembl:ENSP00000314831|ensembl:ENSP00000384367|ensembl:ENSP00000408405|ensembl:ENSP00000464170	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:kctd1_human(display_long)|uniprotkb:KCTD1(gene name)|psi-mi:KCTD1(display_short)|uniprotkb:C18orf5(gene name synonym)|uniprotkb:Potassium channel tetramerization domain-containing protein 1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510636|imex:IM-28561-1373	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:XP_016881197.1|refseq:NP_001129677.1|refseq:NP_001136202.1|refseq:NP_001245150.1|refseq:NP_945342.1|ensembl:ENSG00000134504(gene)|ensembl:ENST00000317932(transcript)|ensembl:ENST00000408011(transcript)|ensembl:ENST00000417602(transcript)|ensembl:ENST00000579973(transcript)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0008134"(transcription factor binding)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042802"(identical protein binding)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0051260"(protein homooligomerization)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR003131(Potassium channel, voltage dependent, Kv,  tetramerisation)|interpro:IPR011333(BTB/POZ fold)|mint:Q719H9|rcsb pdb:5BXB|rcsb pdb:5BXD|rcsb pdb:6S4L|reactome:R-HSA-8866904	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:mv4g8/+TuoNkCitdTYpsxJH52I09606	rigid:phUUcbxS5zLdz3rQIubNhKGjBEY	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q8WZ19	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-742916|ensembl:ENSP00000311202|ensembl:ENSP00000455785|uniprotkb:Q96P93|uniprotkb:Q96SA1|uniprotkb:A8K0R5	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:bacd1_human(display_long)|uniprotkb:Polymerase delta-interacting protein 1(gene name synonym)|uniprotkb:TNFAIP1-like protein(gene name synonym)|uniprotkb:KCTD13(gene name)|psi-mi:KCTD13(display_short)|uniprotkb:PDIP1(gene name synonym)|uniprotkb:POLDIP1(gene name synonym)|uniprotkb:FKSG86(orf name)|uniprotkb:PP6832(orf name)|uniprotkb:BACURD1(gene name synonym)|uniprotkb:BTB/POZ domain-containing protein KCTD13(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510645|imex:IM-28561-901	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_849194.1|ensembl:ENSG00000174943(gene)|ensembl:ENST00000308768(transcript)|ensembl:ENST00000568000(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016477"(cell migration)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051260"(protein homooligomerization)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR003131(Potassium channel, voltage dependent, Kv,  tetramerisation)|interpro:IPR011333(BTB/POZ fold)|mint:Q8WZ19|rcsb pdb:4UIJ|reactome:R-HSA-9696264|reactome:R-HSA-9696270	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:hAH5yJEoda0H1anmnSXWHO0o1ZM9606	rigid:8n+VqG5I155NmZjU+qH9ka6iaHo	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q07666	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-1364|uniprotkb:Q6PJX7|uniprotkb:Q8NB97|uniprotkb:Q99760|uniprotkb:D3DPP3|ensembl:ENSP00000313829	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:khdr1_human(display_long)|uniprotkb:SAM68(gene name synonym)|uniprotkb:Src-associated in mitosis 68 kDa protein(gene name synonym)|uniprotkb:KHDRBS1(gene name)|psi-mi:KHDRBS1(display_short)|uniprotkb:p21 Ras GTPase-activating protein-associated p62(gene name synonym)|uniprotkb:GAP-associated tyrosine phosphoprotein p62(gene name synonym)|uniprotkb:p68(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510652|imex:IM-28561-903	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_006550.1|refseq:NP_001258807.1|dip:DIP-29007N|ensembl:ENSG00000121774(gene)|ensembl:ENST00000327300(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008143"("poly(A) binding")|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046831"(regulation of RNA export from nucleus)|go:"GO:0046833"(positive regulation of RNA export from nucleus)|go:"GO:0048024"(regulation of mRNA splicing, via spliceosome)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0070618"(Grb2-Sos complex)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032335|interpro:IPR032571|interpro:IPR036612|mint:Q07666|rcsb pdb:2XA6|rcsb pdb:3QHE|reactome:R-HSA-8849468	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:po7jC4Nxu+Aoz6T8K6VRWHp6MKQ9606	rigid:k5L//3lXmYGO3nmepweb8lLoRL4	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:O75525	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-722504|uniprotkb:Q6NUL8|uniprotkb:Q9UPA8|ensembl:ENSP00000348108	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:khdr3_human(display_long)|uniprotkb:Sam68-like mammalian protein 2(gene name synonym)|uniprotkb:Sam68-like phosphotyrosine protein(gene name synonym)|uniprotkb:RNA-binding protein T-Star(gene name synonym)|uniprotkb:KHDRBS3(gene name)|psi-mi:KHDRBS3(display_short)|uniprotkb:SALP(gene name synonym)|uniprotkb:SLM2(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510659|imex:IM-28561-1603	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_006549.1|ensembl:ENSG00000131773(gene)|ensembl:ENST00000355849(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0048024"(regulation of mRNA splicing, via spliceosome)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032335|interpro:IPR032571|interpro:IPR036612|mint:O75525|rcsb pdb:5EL3|rcsb pdb:5ELR|rcsb pdb:5ELS|rcsb pdb:5ELT|rcsb pdb:5EMO|reactome:R-HSA-8849468	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:9ZoB3JVp0Q9nxeFRsmWhNThzWoE9606	rigid:S5wCvVLYHT6YNZDdsZ74y/j3OAg	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:P29590	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-295890|ensembl:ENSP00000268058|uniprotkb:P29591|uniprotkb:P29592|uniprotkb:P29593|uniprotkb:Q00755|uniprotkb:Q96S41|intact:EBI-779712|intact:EBI-1210702|intact:EBI-870812|uniprotkb:Q15959|uniprotkb:Q59FP9|uniprotkb:Q8WUA0|uniprotkb:Q9BPW2|uniprotkb:Q9BWP7|uniprotkb:Q9BZX6|uniprotkb:Q9BZX7|uniprotkb:Q9BZX8|uniprotkb:Q9BZX9|uniprotkb:Q9BZY0|uniprotkb:Q9BZY2|uniprotkb:Q9BZY3|uniprotkb:E9PBR7	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:pml_human(display_long)|uniprotkb:PML(gene name)|psi-mi:PML(display_short)|uniprotkb:MYL(gene name synonym)|uniprotkb:RNF71(gene name synonym)|uniprotkb:TRIM19(gene name synonym)|uniprotkb:Tripartite motif-containing protein 19(gene name synonym)|uniprotkb:RING finger protein 71(gene name synonym)|uniprotkb:Promyelocytic leukemia protein(gene name synonym)|uniprotkb:PP8675(gene name synonym)|uniprotkb:E3 SUMO-protein ligase PML(gene name synonym)|uniprotkb:RING-type E3 SUMO transferase PML(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511015|imex:IM-28561-721	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	ensembl:ENST00000268058(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003677"(DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|ensembl:ENSG00000140464(gene)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006605"(protein targeting)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0009411"(response to UV)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010522"(regulation of calcium ion transport into cytosol)|go:"GO:0005829"(cytosol)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016605"(PML body)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030578"(PML body organization)|go:"GO:0031065"(positive regulation of histone deacetylation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032183"(SUMO binding)|go:"GO:0032206"(positive regulation of telomere maintenance)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0010761"(fibroblast migration)|go:"GO:0034097"(response to cytokine)|go:"GO:0042406"(extrinsic component of endoplasmic reticulum membrane)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0032938"(negative regulation of translation in response to oxidative stress)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0046332"(SMAD binding)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0050821"(protein stabilization)|go:"GO:0050897"(cobalt ion binding)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0051607"(defense response to virus)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060058"(positive regulation of apoptotic process involved in mammary gland involution)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0090398"(cellular senescence)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0140037"(sumo-dependent protein binding)|go:"GO:1902187"|go:"GO:1904816"(positive regulation of protein localization to chromosome, telomeric region)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|rcsb pdb:2MWX|rcsb pdb:4WJN|rcsb pdb:4WJO|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|rcsb pdb:5YUF|go:"GO:2000779"(regulation of double-strand break repair)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000315(Zinc finger, B-box)|rcsb pdb:6IMQ|rcsb pdb:6UYO|rcsb pdb:6UYP|interpro:IPR001841(Zinc finger, RING-type)|rcsb pdb:6UYQ|rcsb pdb:6UYR|rcsb pdb:6UYS|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|rcsb pdb:6UYT|rcsb pdb:6UYU|rcsb pdb:6UYV|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-6804758|reactome:R-HSA-877300|reactome:R-HSA-8934593|reactome:R-HSA-8948747|reactome:R-HSA-9609690|reactome:R-HSA-9616222|interpro:IPR021978|mint:P29590|rcsb pdb:1BOR|rcsb pdb:2MVW|refseq:NP_002666.1|refseq:NP_150241.2|refseq:NP_150242.1|refseq:NP_150243.2|refseq:NP_150247.2|refseq:NP_150249.1|refseq:NP_150250.2|refseq:NP_150252.1|refseq:NP_150253.2|dip:DIP-33053N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:FdAh5Rbyu37luTScMzCopbbwXvk9606	rigid:kpIEK7arLemf28ESOJdeiDLYhq0	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:P14618	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-353408|uniprotkb:A6NFK3|uniprotkb:P14786|uniprotkb:Q53GK4|uniprotkb:Q96E76|uniprotkb:Q9BWB5|uniprotkb:Q9UPF2|uniprotkb:B2R5N8|uniprotkb:B3KRY0|uniprotkb:B4DFX8|uniprotkb:Q9UCV6|intact:EBI-2555890|uniprotkb:B4DUU6|ensembl:ENSP00000334983	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:kpym_human(display_long)|uniprotkb:PKM(gene name)|psi-mi:PKM(display_short)|uniprotkb:Cytosolic thyroid hormone-binding protein(gene name synonym)|uniprotkb:OIP3(gene name synonym)|uniprotkb:Opa-interacting protein 3(gene name synonym)|uniprotkb:PK2(gene name synonym)|uniprotkb:PK3(gene name synonym)|uniprotkb:PKM2(gene name synonym)|uniprotkb:Pyruvate kinase 2/3(gene name synonym)|uniprotkb:Pyruvate kinase muscle isozyme(gene name synonym)|uniprotkb:Thyroid hormone-binding protein 1(gene name synonym)|uniprotkb:Tumor M2-PK(gene name synonym)|uniprotkb:p58(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511006|imex:IM-28561-523	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_001193725.1|refseq:NP_001193727.1|refseq:NP_001193728.1|refseq:NP_002645.3|refseq:NP_872270.1|refseq:NP_872271.1|refseq:NP_001193726.1|refseq:NP_001303247.1|refseq:XP_005254502.1|dip:DIP-31273N|ensembl:ENSG00000067225(gene)|ensembl:ENST00000335181(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004743"(pyruvate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0006096"(glycolytic process)|go:"GO:0012501"(programmed cell death)|go:"GO:0016301"(kinase activity)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031982"(vesicle)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0045296"(cadherin binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2000767"(positive regulation of cytoplasmic translation)|interpro:IPR001697(Pyruvate kinase)|interpro:IPR011037(Pyruvate kinase, beta-barrel-like)|interpro:IPR015793(Pyruvate kinase, barrel)|interpro:IPR015795(Pyruvate kinase, C-terminal-like)|interpro:IPR015806(Pyruvate kinase, beta-barrel)|interpro:IPR015813(Pyruvate/Phosphoenolpyruvate kinase, catalytic core)|interpro:IPR018209|interpro:IPR036918|interpro:IPR040442|mint:P14618|rcsb pdb:1T5A|rcsb pdb:1ZJH|rcsb pdb:3BJF|rcsb pdb:3BJT|rcsb pdb:3G2G|rcsb pdb:3GQY|rcsb pdb:3GR4|rcsb pdb:3H6O|rcsb pdb:3ME3|rcsb pdb:3SRD|rcsb pdb:3SRF|rcsb pdb:3U2Z|rcsb pdb:4B2D|rcsb pdb:4FXF|rcsb pdb:4FXJ|rcsb pdb:4G1N|rcsb pdb:4JPG|rcsb pdb:4QG6|rcsb pdb:4QG8|rcsb pdb:4QG9|rcsb pdb:4QGC|rcsb pdb:4RPP|rcsb pdb:4WJ8|rcsb pdb:4YJ5|rcsb pdb:5X0I|rcsb pdb:5X1V|rcsb pdb:5X1W|rcsb pdb:6B6U|rcsb pdb:6GG3|rcsb pdb:6GG4|rcsb pdb:6GG5|rcsb pdb:6GG6|rcsb pdb:6JFB|rcsb pdb:6NU1|rcsb pdb:6NU5|rcsb pdb:6NUB|rcsb pdb:6TTF|rcsb pdb:6TTH|rcsb pdb:6TTI|rcsb pdb:6TTQ|rcsb pdb:6V74|rcsb pdb:3SRH|rcsb pdb:6V75|rcsb pdb:6V76|rcsb pdb:6WP3|rcsb pdb:6WP4|rcsb pdb:6WP5|rcsb pdb:6WP6|reactome:R-HSA-6798695|reactome:R-HSA-70171|refseq:XP_016877802.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:dDaoXCaqd0x6qFSElvngHusttuk9606	rigid:5riIOSRKaKcxhhCQioNrXp29xQ0	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q86UU1	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-4289858|uniprotkb:Q4KMF8|uniprotkb:Q8TEQ2|uniprotkb:O75133|uniprotkb:B0YJ63|uniprotkb:B0YJ64|intact:EBI-28975144|ensembl:ENSP00000354498|ensembl:ENSP00000469820	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:phlb1_human(display_long)|uniprotkb:PHLDB1(gene name)|psi-mi:PHLDB1(display_short)|uniprotkb:KIAA0638(gene name synonym)|uniprotkb:LL5A(gene name synonym)|uniprotkb:Protein LL5-alpha(gene name synonym)|uniprotkb:DLNB07(orf name)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510999|imex:IM-28561-281	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	ensembl:ENST00000356063|ensembl:ENSP00000348359|ensembl:ENSP00000354498|ensembl:ENST00000528594|ensembl:ENSP00000435520|ensembl:ENST00000530994|ensembl:ENSP00000431508|ensembl:ENSP00000469820|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR037810|mint:Q86UU1|ensembl:ENSG00000019144(gene)|ensembl:ENST00000361417(transcript)|ensembl:ENST00000600882(transcript)|go:"GO:0010470"(regulation of gastrulation)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0045180"(basal cortex)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:1904261"(positive regulation of basement membrane assembly involved in embryonic body morphogenesis)|interpro:IPR000253(Forkhead-associated)|interpro:IPR001849(Pleckstrin-like)|refseq:NP_001138230.1|refseq:NP_001138231.1|refseq:NP_055972.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:Za4UuXVuMr4gzY2kr8EadOf5hWA9606	rigid:1x5e2/hSIXxZdQpnX0LiBulI6fs	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q8IXK0	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-713786|uniprotkb:Q8N306|uniprotkb:Q8TAG8|uniprotkb:A1L4Q1|uniprotkb:Q2TAL3|uniprotkb:Q5T0C1|uniprotkb:Q6NUJ6|uniprotkb:Q6ZQR1|uniprotkb:Q96BL4|uniprotkb:Q9Y4Y7|ensembl:ENSP00000257118|uniprotkb:D3DPR2|uniprotkb:A8KA40	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:phc2_human(display_long)|uniprotkb:Early development regulatory protein 2(gene name synonym)|uniprotkb:PHC2(gene name)|psi-mi:PHC2(display_short)|uniprotkb:EDR2(gene name synonym)|uniprotkb:PH2(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510992|imex:IM-28561-101	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	interpro:IPR038603|mint:Q8IXK0|reactome:R-HSA-2559580|reactome:R-HSA-3108214|reactome:R-HSA-3899300|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4655427|reactome:R-HSA-8939243|reactome:R-HSA-8943724|interpro:IPR013761(Sterile alpha motif-type)|ensembl:ENSG00000134686(gene)|ensembl:ENST00000257118(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0031519"(PcG protein complex)|go:"GO:0035102"(PRC1 complex)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR012313(Zinc finger, FCS-type)|refseq:NP_004418.2|refseq:NP_932157.1|refseq:XP_016856005.1|refseq:XP_016856006.1|refseq:XP_016856007.1|refseq:XP_005270627.1|dip:DIP-34464N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:7si/KU2tHoxviuCr70ncQERDWmY9606	rigid:hk8nZFHUOjIAIj47PeGig3lBW5Y	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:P78364	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-725403|uniprotkb:Q8WVM3|uniprotkb:Q9BU63|uniprotkb:D3DUV4|ensembl:ENSP00000437659|ensembl:ENSP00000440674	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:phc1_human(display_long)|uniprotkb:Early development regulatory protein 1(gene name synonym)|uniprotkb:PHC1(gene name)|psi-mi:PHC1(display_short)|uniprotkb:EDR1(gene name synonym)|uniprotkb:PH1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510985|imex:IM-28561-521	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_004417.2|ensembl:ENSG00000111752(gene)|ensembl:ENST00000543824(transcript)|ensembl:ENST00000544916(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031519"(PcG protein complex)|go:"GO:0035102"(PRC1 complex)|go:"GO:0042393"(histone binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR012313(Zinc finger, FCS-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR038603|mint:P78364|rcsb pdb:2L8E|reactome:R-HSA-2559580|reactome:R-HSA-3108214|reactome:R-HSA-3899300|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4655427|reactome:R-HSA-8939243|reactome:R-HSA-8943724|reactome:R-HSA-8953750|dip:DIP-44567N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:0dDjrgvWcP5Sx8h+qUj7awuM3ko9606	rigid:MfrZFr7cMqgSvzLgW47WI/unkb8	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:O76083	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-742764|uniprotkb:O75490|uniprotkb:O75491|uniprotkb:O95225|uniprotkb:Q86SF7|uniprotkb:Q86SI6|uniprotkb:Q86SJ3|uniprotkb:Q86WN3|uniprotkb:Q86WN4|uniprotkb:Q86WN5|uniprotkb:Q86WN6|uniprotkb:Q86WN7|uniprotkb:Q86WN8|uniprotkb:Q86WN9|uniprotkb:Q86WP0|uniprotkb:B2RBI5|uniprotkb:Q53Y40|uniprotkb:B4DFI5|uniprotkb:Q5QD39|uniprotkb:D3DSJ8|uniprotkb:D3DSJ9|ensembl:ENSP00000291539	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:pde9a_human(display_long)|uniprotkb:PDE9A(gene name)|psi-mi:PDE9A(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510978|imex:IM-28561-1663	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	rcsb pdb:3DYS|refseq:NP_001001567.1|refseq:NP_001001568.1|refseq:NP_001001569.1|refseq:NP_001001570.1|refseq:NP_001001571.1|refseq:NP_001001572.1|refseq:NP_001001573.1|refseq:NP_001001574.1|refseq:NP_001001575.1|refseq:NP_001001576.1|refseq:NP_001001577.1|refseq:NP_001001578.1|refseq:NP_001001579.1|refseq:NP_001001580.1|refseq:NP_001001581.1|refseq:NP_001001582.1|refseq:NP_001001583.1|refseq:NP_001001584.1|refseq:NP_001001585.1|refseq:NP_002597.1|refseq:NP_001302462.1|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0046068"(cGMP metabolic process)|go:"GO:0046069"(cGMP catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0047555"(3',5'-cyclic-GMP phosphodiesterase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR002073(3'5'-cyclic nucleotide phosphodiesterase)|interpro:IPR003607(Metal-dependent phosphohydrolase, HD region)|interpro:IPR023088|ensembl:ENSG00000160191(gene)|ensembl:ENST00000291539(transcript)|go:"GO:0004114"(3',5'-cyclic-nucleotide phosphodiesterase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0032587"(ruffle membrane)|interpro:IPR023174|interpro:IPR036971|mint:O76083|rcsb pdb:2HD1|rcsb pdb:2YY2|rcsb pdb:3DY8|rcsb pdb:3DYL|rcsb pdb:3DYN|rcsb pdb:3DYQ|rcsb pdb:3JSW|rcsb pdb:3K3E|rcsb pdb:3K3H|rcsb pdb:3N3Z|rcsb pdb:3QI3|rcsb pdb:3QI4|rcsb pdb:4E90|rcsb pdb:4G2J|rcsb pdb:4G2L|rcsb pdb:4GH6|rcsb pdb:4Y86|rcsb pdb:4Y87|rcsb pdb:4Y8C|rcsb pdb:6A3N|rcsb pdb:6LZZ|reactome:R-HSA-418457|rcsb pdb:3JSI|refseq:XP_016883855.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:ihS9g9TSkHsEA4olMOO+krgypow9606	rigid:mHHVYx9S4KxWrmT2Yr49aJmP3kY	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:P05166	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-1371908|uniprotkb:Q16813|uniprotkb:Q96CX0|uniprotkb:B7Z2Z4|ensembl:ENSP00000251654	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:pccb_human(display_long)|uniprotkb:PCCB(gene name)|psi-mi:PCCB(display_short)|uniprotkb:"Propanoyl-CoA:carbon dioxide ligase subunit beta"(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510969|imex:IM-28561-1161	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_000523.2|refseq:NP_001171485.1|dip:DIP-38244N|mint:P05166|reactome:R-HSA-196780|reactome:R-HSA-3371599|reactome:R-HSA-71032|interpro:IPR034733|ensembl:ENSG00000114054(gene)|ensembl:ENST00000251654(transcript)|go:"GO:0004658"(propionyl-CoA carboxylase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0019626"(short-chain fatty acid catabolic process)|interpro:IPR011762(Acetyl-coenzyme A carboxyltransferase, N-terminal)|interpro:IPR011763(Acetyl-coenzyme A carboxyltransferase, C-terminal)|interpro:IPR029045	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:QyhO7MHvNRxNMg7ohwi1xS+VxQE9606	rigid:bBlj7LeNJf23ewTdGcXsaVBIGMQ	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:P22234	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-712261|ensembl:ENSP00000264221|ensembl:ENSP00000421096|uniprotkb:E9PDH9|uniprotkb:Q68CQ5|intact:EBI-21352784	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:pur6_human(display_long)|uniprotkb:PAICS(gene name)|psi-mi:PAICS(display_short)|uniprotkb:ADE2(gene name synonym)|uniprotkb:AIRC(gene name synonym)|uniprotkb:PAIS(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510962|imex:IM-28561-81	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	ensembl:ENSG00000128050(gene)|ensembl:ENST00000264221(transcript)|ensembl:ENST00000512576(transcript)|go:"GO:0004639"(phosphoribosylaminoimidazolesuccinocarboxamide synthase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006189"('de novo' IMP biosynthetic process)|go:"GO:0009113"(purine nucleobase biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043727"(5-amino-4-imidazole carboxylate lyase activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000031("1-(5-Phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase")|interpro:IPR018236|interpro:IPR028923|interpro:IPR033626|mint:P22234|rcsb pdb:2H31|rcsb pdb:6YB8|go:"GO:0004638"(phosphoribosylaminoimidazole carboxylase activity)|rcsb pdb:6YB9|reactome:R-HSA-73817|refseq:NP_001072992.1|refseq:NP_001072993.1|refseq:NP_006443.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:aR4Xj14ZQrPiY8cldw5o9AvjkAo9606	rigid:vfDOi2ClQ0SMrqdblt3ypKuSe50	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q15102	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-711522|uniprotkb:Q53X88|ensembl:ENSP00000262890|ensembl:ENSP00000444935	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:pa1b3_human(display_long)|uniprotkb:PAFAH1B3(gene name)|psi-mi:PAFAH1B3(display_short)|uniprotkb:PAFAHG(gene name synonym)|uniprotkb:PAF acetylhydrolase 29 kDa subunit(gene name synonym)|uniprotkb:PAF-AH subunit gamma(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510953|imex:IM-28561-501	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	go:"GO:0016042"(lipid catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0047179"(platelet-activating factor acetyltransferase activity)|interpro:IPR013830(Esterase, SGNH hydrolase-type)|interpro:IPR036514|mint:Q15102|reactome:R-HSA-6811436|go:"GO:0005829"(cytosol)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0008247"(1-alkyl-2-acetylglycerophosphocholine esterase complex)|go:"GO:0016020"(membrane)|ensembl:ENSG00000079462(gene)|ensembl:ENST00000262890(transcript)|ensembl:ENST00000538771(transcript)|go:"GO:0003847"(1-alkyl-2-acetylglycerophosphocholine esterase activity)|go:"GO:0005737"(cytoplasm)|refseq:NP_001139411.1|refseq:NP_001139412.1|refseq:NP_002564.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:yxVKkXAs2AmH+fZFUW+hZN889k89606	rigid:AzdOddIlzrxntx3uLpz7tmRiF18	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:P48745	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-3904822|uniprotkb:Q6I9S3|uniprotkb:Q9UDE4|uniprotkb:Q96BY5|uniprotkb:B2R5X7|ensembl:ENSP00000259526	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:ccn3_human(display_long)|uniprotkb:CCN3(gene name)|psi-mi:CCN3(display_short)|uniprotkb:Cellular communication network factor 3(gene name synonym)|uniprotkb:IGFBP9(gene name synonym)|uniprotkb:Insulin-like growth factor-binding protein 9(gene name synonym)|uniprotkb:NOV(gene name synonym)|uniprotkb:NOVH(gene name synonym)|uniprotkb:Nephro blastoma-overexpressed gene protein homolog(gene name synonym)|uniprotkb:Protein NOV homolog(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510944|imex:IM-28561-911	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_002505.1|ensembl:ENSG00000136999(gene)|ensembl:ENST00000259526(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0005112"(Notch binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005921"(gap junction)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010761"(fibroblast migration)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0014909"(smooth muscle cell migration)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031012"(extracellular matrix)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0035767"(endothelial cell chemotaxis)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044342"(type B pancreatic cell proliferation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0048659"(smooth muscle cell proliferation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060392"(negative regulation of SMAD protein signal transduction)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061484"(hematopoietic stem cell homeostasis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071603"(endothelial cell-cell adhesion)|go:"GO:0090027"(negative regulation of monocyte chemotaxis)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1902731"(negative regulation of chondrocyte proliferation)|go:"GO:1904057"(negative regulation of sensory perception of pain)|go:"GO:1990523"(bone regeneration)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR006208(Cystine knot)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR012395(IGFBP-related, CNN)|interpro:IPR017891|interpro:IPR036383|interpro:IPR043973|mint:P48745	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:3IUgIO3Q676ryvJXOCfCvHmcC789606	rigid:6wHJIfMq0TNMHrn5geoCb9mma3o	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q15233	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-350527|ensembl:ENSP00000503233|uniprotkb:O00201|uniprotkb:P30807|uniprotkb:Q12786|uniprotkb:Q9BQC5|ensembl:ENSP00000276079|ensembl:ENSP00000362947|ensembl:ENSP00000406673|ensembl:ENSP00000410299|ensembl:ENSP00000415777|ensembl:ENSP00000503031|ensembl:ENSP00000504314|ensembl:ENSP00000504351|uniprotkb:D3DVV4|uniprotkb:B7Z4C2|uniprotkb:F5GYZ3	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:nono_human(display_long)|uniprotkb:NONO(gene name)|psi-mi:NONO(display_short)|uniprotkb:NRB54(gene name synonym)|uniprotkb:54 kDa nuclear RNA- and DNA-binding protein(gene name synonym)|uniprotkb:"p54(nrb)"(gene name synonym)|uniprotkb:55 kDa nuclear protein(gene name synonym)|uniprotkb:NMT55(gene name synonym)|uniprotkb:DNA-binding p52/p100 complex, 52 kDa subunit(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510937|imex:IM-28561-467	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_001138880.1|refseq:NP_001138881.1|refseq:NP_001138882.1|refseq:NP_031389.3|ensembl:ENSG00000147140(gene)|ensembl:ENST00000276079(transcript)|ensembl:ENST00000373841(transcript)|ensembl:ENST00000420903(transcript)|ensembl:ENST00000450092(transcript)|ensembl:ENST00000454976(transcript)|ensembl:ENST00000677274(transcript)|ensembl:ENST00000677446(transcript)|ensembl:ENST00000677612(transcript)|ensembl:ENST00000678231(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001650"(fibrillar center)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006397"(mRNA processing)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008380"(RNA splicing)|go:"GO:0016020"(membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0042382"(paraspeckles)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1903377"(negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR012975(NOPS)|interpro:IPR034552|interpro:IPR035979|mint:Q15233|rcsb pdb:3SDE|rcsb pdb:5IFM|rcsb pdb:6WMZ|rcsb pdb:7LRQ|dip:DIP-29951N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:5W3ooO4h0qh3GKO+WjDrLBhihHA9606	rigid:8DVI6hNHqWMa2j22pMGuqsEH0SE	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q13232	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-713684|uniprotkb:Q9BWH4|ensembl:ENSP00000219302	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:ndk3_human(display_long)|uniprotkb:Nucleoside diphosphate kinase C(gene name synonym)|uniprotkb:nm23-H3(gene name synonym)|uniprotkb:DR-nm23(gene name synonym)|uniprotkb:NME3(gene name)|psi-mi:NME3(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510928|imex:IM-28561-1611	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	ensembl:ENSG00000103024(gene)|ensembl:ENST00000219302(transcript)|go:"GO:0004550"(nucleoside diphosphate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006183"(GTP biosynthetic process)|go:"GO:0006228"(UTP biosynthetic process)|go:"GO:0006241"(CTP biosynthetic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0046872"(metal ion binding)|interpro:IPR001564(Nucleoside diphosphate kinase, core)|interpro:IPR023005|interpro:IPR034907|interpro:IPR036850|mint:Q13232|rcsb pdb:1ZS6|reactome:R-HSA-499943|refseq:NP_002504.2|dip:DIP-49960N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:/egrHNJSuCILf6NdwwchG9rUGqI9606	rigid:RMBhKEdUdDqEHwXlvCRC1w0RxPI	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:P22392	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-713693|ensembl:ENSP00000376886|ensembl:ENSP00000421064|ensembl:ENSP00000425581|ensembl:ENSP00000426901|ensembl:ENSP00000426976|uniprotkb:A8MWA3|uniprotkb:Q1WM23|uniprotkb:Q6LCT6	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:ndkb_human(display_long)|uniprotkb:nm23-H2(gene name synonym)|uniprotkb:C-myc purine-binding transcription factor PUF(gene name synonym)|uniprotkb:NME2(gene name)|psi-mi:NME2(display_short)|uniprotkb:NM23B(gene name synonym)|uniprotkb:Histidine protein kinase NDKB(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510919|imex:IM-28561-1609	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	ensembl:ENSG00000243678(gene)|ensembl:ENST00000393190(transcript)|ensembl:ENST00000503064(transcript)|ensembl:ENST00000512737(transcript)|ensembl:ENST00000513177(transcript)|ensembl:ENST00000514264(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0002762"(negative regulation of myeloid leukocyte differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004550"(nucleoside diphosphate kinase activity)|go:"GO:0004673"(protein histidine kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005504"(fatty acid binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|refseq:NP_001018146.1|refseq:NP_001018147.1|refseq:NP_001018148.1|refseq:NP_001018149.1|refseq:NP_002503.1|dip:DIP-50179N|go:"GO:0005882"(intermediate filament)|go:"GO:0006165"(nucleoside diphosphate phosphorylation)|go:"GO:0006183"(GTP biosynthetic process)|go:"GO:0006228"(UTP biosynthetic process)|go:"GO:0006241"(CTP biosynthetic process)|go:"GO:0007155"(cell adhesion)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009142"(nucleoside triphosphate biosynthetic process)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0060416"(response to growth hormone)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071944"(cell periphery)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR001564(Nucleoside diphosphate kinase, core)|interpro:IPR023005|interpro:IPR034907|interpro:IPR036850|mint:P22392|rcsb pdb:1NSK|rcsb pdb:1NUE|rcsb pdb:3BBB|rcsb pdb:3BBC|rcsb pdb:3BBF|reactome:R-HSA-499943|reactome:R-HSA-6798695|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0019003"(GDP binding)|go:"GO:0019215"(intermediate filament binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045618"(positive regulation of keratinocyte differentiation)|go:"GO:0045682"(regulation of epidermis development)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:GHHfoXOuc25KIJJqiW9r+OWm5Kk9606	rigid:oD2jbzn1JiINY7TVv/cpIhh5ddc	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:P15531	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-741141|ensembl:ENSP00000376892|uniprotkb:Q6FGK3|uniprotkb:Q86XQ2|uniprotkb:Q9UDJ6	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:ndka_human(display_long)|uniprotkb:Tumor metastatic process-associated protein(gene name synonym)|uniprotkb:Metastasis inhibition factor nm23(gene name synonym)|uniprotkb:Granzyme A-activated DNase(gene name synonym)|uniprotkb:NME1(gene name)|psi-mi:NME1(display_short)|uniprotkb:NDPKA(gene name synonym)|uniprotkb:NM23(gene name synonym)|uniprotkb:NM23-H1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510910|imex:IM-28561-249	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_000260.1|refseq:NP_937818.1|ensembl:ENSG00000239672(gene)|ensembl:ENST00000393196(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0002762"(negative regulation of myeloid leukocyte differentiation)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004536"(deoxyribonuclease activity)|go:"GO:0004550"(nucleoside diphosphate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0006183"(GTP biosynthetic process)|go:"GO:0006228"(UTP biosynthetic process)|go:"GO:0006241"(CTP biosynthetic process)|go:"GO:0006897"(endocytosis)|go:"GO:0007595"(lactation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014075"(response to amine)|go:"GO:0016020"(membrane)|go:"GO:0019215"(intermediate filament binding)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051591"(response to cAMP)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071398"(cellular response to fatty acid)|interpro:IPR001564(Nucleoside diphosphate kinase, core)|go:"GO:0019899"(enzyme binding)|interpro:IPR023005|go:"GO:0021766"(hippocampus development)|interpro:IPR034907|interpro:IPR036850|mint:P15531|go:"GO:0030154"(cell differentiation)|go:"GO:0032587"(ruffle membrane)|rcsb pdb:1JXV|rcsb pdb:1UCN|go:"GO:0033574"(response to testosterone)|go:"GO:0035690"|rcsb pdb:2HVD|rcsb pdb:2HVE|rcsb pdb:3L7U|rcsb pdb:4ENO|rcsb pdb:5UI4|reactome:R-HSA-499943|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043024"(ribosomal small subunit binding)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|dip:DIP-39164N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:Ut4gK1Xq786CaZzvqdS1eiU5op89606	rigid:7PwOwU11PtchZ+BAt6Sl5k7MxaY	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q969F2	uniprotkb:P51114	intact:EBI-1538629|uniprotkb:Q96EK8|uniprotkb:Q9BSN0|ensembl:ENSP00000296849|ensembl:ENSP00000479003	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	psi-mi:nkd2_human(display_long)|uniprotkb:NKD2(gene name)|psi-mi:NKD2(display_short)	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510901|imex:IM-28561-465	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_149111.1|refseq:NP_001258011.1|ensembl:ENST00000274150|ensembl:ENSP00000274150|ensembl:ENSP00000296849|ensembl:ENST00000610777|ensembl:ENSP00000482896|ensembl:ENSP00000479003|dip:DIP-38642N|ensembl:ENSG00000145506(gene)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019838"(growth factor binding)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032036"(myosin heavy chain binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0048210"(Golgi vesicle fusion to target membrane)|ensembl:ENSG00000276920(gene)|ensembl:ENST00000296849(transcript)|ensembl:ENST00000616539(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0051117"(ATPase binding)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0071944"(cell periphery)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR040140|mint:Q969F2	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:kQxbG3sbnbXPkaywAkvN6ip1+Bw9606	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rigid:vS/xktUyPpvrZGlTlsydIYr7ubs	false	-	sufficient binding region:215-363	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:P07196	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-475646|uniprotkb:Q16154|uniprotkb:B9ZVN2|uniprotkb:Q8IU72|ensembl:ENSP00000482169	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:nfl_human(display_long)|uniprotkb:Neurofilament triplet L protein(gene name synonym)|uniprotkb:68 kDa neurofilament protein(gene name synonym)|uniprotkb:NEFL(gene name)|psi-mi:NEFL(display_short)|uniprotkb:NF68(gene name synonym)|uniprotkb:NFL(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510892|imex:IM-28561-47	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_006149.2|ensembl:ENSG00000277586(gene)|ensembl:ENST00000610854(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005883"(neurofilament)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0009636"(response to toxic substance)|go:"GO:0014012"(peripheral nervous system axon regeneration)|go:"GO:0019896"(axonal transport of mitochondrion)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021510"(spinal cord development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030424"(axon)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031133"(regulation of axon diameter)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0033693"(neurofilament bundle assembly)|go:"GO:0040011"(locomotion)|go:"GO:0042802"(identical protein binding)|go:"GO:0030426"(growth cone)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045105"(intermediate filament polymerization or depolymerization)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051258"(protein polymerization)|go:"GO:0051412"(response to corticosterone)|go:"GO:0060052"(neurofilament cytoskeleton organization)|go:"GO:0060074"(synapse maturation)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098981"(cholinergic synapse)|go:"GO:0099160"(postsynaptic intermediate filament cytoskeleton)|go:"GO:0099182"(presynaptic intermediate filament cytoskeleton)|go:"GO:0099184"(structural constituent of postsynaptic intermediate filament cytoskeleton)|go:"GO:1903935"(response to sodium arsenite)|go:"GO:1903937"(response to acrylamide)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|interpro:IPR027692|interpro:IPR039008|mint:P07196|reactome:R-HSA-438066|reactome:R-HSA-442982|reactome:R-HSA-5673001|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-9620244	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:tgdjWnqcql4YMbd89ujbDoqN/Yg9606	rigid:e3l4+UoID/yjKEq8Y0JAmO5FAFI	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q96P71	uniprotkb:P51114	intact:EBI-5773009|uniprotkb:Q9H433|uniprotkb:Q5JWF6|uniprotkb:Q5JWF5|uniprotkb:Q9HCQ9|uniprotkb:Q5JWF7|uniprotkb:Q9H8G8|uniprotkb:A8K780|uniprotkb:Q9HBW7|uniprotkb:E1P5N2|uniprotkb:Q86VV1|ensembl:ENSP00000246190	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	psi-mi:neca3_human(display_long)|uniprotkb:Amyloid-beta A4 protein-binding family A member 2-binding protein(gene name synonym)|uniprotkb:NECAB3(gene name)|psi-mi:NECAB3(display_short)|uniprotkb:APBA2BP(gene name synonym)|uniprotkb:NIP1(gene name synonym)|uniprotkb:Nek2-interacting protein 1(gene name synonym)|uniprotkb:Neuronal calcium-binding protein 3(gene name synonym)|uniprotkb:SYTIP2(gene name synonym)|uniprotkb:X11L-binding protein 51(gene name synonym)|uniprotkb:XB51(gene name synonym)	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510883|imex:IM-28561-1385	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_112508.3|refseq:NP_112509.3|ensembl:ENSG00000125967(gene)|ensembl:ENST00000246190(transcript)|go:"GO:0000137"(Golgi cis cisterna)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0009306"(protein secretion)|go:"GO:0019538"(protein metabolic process)|go:"GO:0042984"(regulation of amyloid precursor protein biosynthetic process)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR007138(Antibiotic biosynthesis monooxygenase)|interpro:IPR011008(Dimeric alpha-beta barrel)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR039862|mint:Q96P71	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:I2inlkjnL4kDeYl7geuy7tEaRI09606	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rigid:w/PqkQGG1Co/gt/YZZpRkZpMUU0	false	-	sufficient binding region:215-363	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q7Z6G3	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-950070|ensembl:ENSP00000307449|uniprotkb:A2RRG3|uniprotkb:O75547|uniprotkb:Q6ZSK0|uniprotkb:H3BTW2	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:neca2_human(display_long)|uniprotkb:Neuronal calcium-binding protein 2(gene name synonym)|uniprotkb:Synaptotagmin-interacting protein 2(gene name synonym)|uniprotkb:NECAB2(gene name)|psi-mi:NECAB2(display_short)|uniprotkb:EFCBP2(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510874|imex:IM-28561-247	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	ensembl:ENSG00000103154(gene)|ensembl:ENST00000305202(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031687"(A2A adenosine receptor binding)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042984"(regulation of amyloid precursor protein biosynthetic process)|go:"GO:0060168"(positive regulation of adenosine receptor signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1904021"(negative regulation of G protein-coupled receptor internalization)|go:"GO:1905477"(positive regulation of protein localization to membrane)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR007138(Antibiotic biosynthesis monooxygenase)|interpro:IPR011008(Dimeric alpha-beta barrel)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR039862|mint:Q7Z6G3|refseq:NP_061938.2|refseq:NP_001316678.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:Op/JNOBupSCF1U3MCeNmJ6gUUrg9606	rigid:4xFu1bZvrjrBB/gRKiy4IW1sf+E	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q8N660	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-2863570|uniprotkb:A8MPT6|uniprotkb:Q3BBV9|uniprotkb:Q5SXJ2|uniprotkb:Q8IX77|intact:EBI-8476726|intact:MINT-8417699|intact:EBI-28968964|ensembl:ENSP00000462600|ensembl:ENSP00000463178|ensembl:ENSP00000481835	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:nbpff_human(display_long)|uniprotkb:NBPF15(gene name)|psi-mi:NBPF15(display_short)|uniprotkb:NBPF16(gene name synonym)|uniprotkb:Neuroblastoma breakpoint family member 16(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510867|imex:IM-28561-1607	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	ensembl:ENSP00000481835|ensembl:ENSP00000462600|ensembl:ENSP00000463178|refseq:XP_016856566.1|refseq:NP_001164226.1|refseq:NP_775909.2|ensembl:ENSG00000266338(gene)|ensembl:ENST00000488031(transcript)|ensembl:ENST00000577412(transcript)|ensembl:ENST00000581897(transcript)|go:"GO:0005737"(cytoplasm)|interpro:IPR010630(Protein of unknown function DUF1220)|mint:Q8N660	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:guAWZ1op9NzRflXheR0SsSzinoM9606	rigid:JJl3ni1Bw2BLwgZxDMFVIrk5/aA	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:O15049	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-2512055|ensembl:ENSP00000274605|uniprotkb:Q7Z6I3|uniprotkb:B4DIL3|uniprotkb:D3DWP3|uniprotkb:Q6ZSQ6	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:n4bp3_human(display_long)|uniprotkb:N4BP3(gene name)|psi-mi:N4BP3(display_short)|uniprotkb:KIAA0341(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510858|imex:IM-28561-701	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	ensembl:ENSG00000145911(gene)|ensembl:ENST00000274605(transcript)|go:"GO:0007399"(nervous system development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031410"(cytoplasmic vesicle)|interpro:IPR033571|mint:O15049|refseq:XP_011532775.1|refseq:XP_011532776.1|ensembl:ENSP00000274605|refseq:NP_055926.1|refseq:XP_006714897.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:rggbUyFRXczrPNjvyOUieC/Fj0c9606	rigid:xb74wJYZsU1xNYxxgAr9G+8YSok	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q49A26	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-2804292|ensembl:ENSP00000322716|uniprotkb:Q6P1Q2|uniprotkb:C9JJ40|uniprotkb:Q9BTI1|uniprotkb:Q9BXK2|uniprotkb:Q6V3W7|uniprotkb:C9JJ60|uniprotkb:B4DL47|uniprotkb:Q5U632	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:glyr1_human(display_long)|uniprotkb:HIBDL(gene name synonym)|uniprotkb:NP60(gene name synonym)|uniprotkb:3-hydroxyisobutyrate dehydrogenase-like protein(gene name synonym)|uniprotkb:Cytokine-like nuclear factor N-PAC(gene name synonym)|uniprotkb:Glyoxylate reductase 1 homolog(gene name synonym)|uniprotkb:Nuclear protein NP60(gene name synonym)|uniprotkb:Nuclear protein of 60 kDa(gene name synonym)|uniprotkb:GLYR1(gene name)|psi-mi:GLYR1(display_short)|uniprotkb:NDF(gene name synonym)|uniprotkb:Nucleosome-destabilizing factor(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510849|imex:IM-28561-459	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	ensembl:ENSG00000140632(gene)|ensembl:ENST00000321919(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0031491"(nucleosome binding)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0042393"(histone binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050661"(NADP binding)|go:"GO:0051287"(NAD binding)|interpro:IPR000313(PWWP)|interpro:IPR006115(6-phosphogluconate dehydrogenase, NAD-binding)|interpro:IPR008927(6-phosphogluconate dehydrogenase, C-terminal-like)|interpro:IPR013328(Dehydrogenase, multihelical)|interpro:IPR029154|interpro:IPR035501|interpro:IPR036291|mint:Q49A26|rcsb pdb:2UYY|rcsb pdb:4GUR|rcsb pdb:4GUS|rcsb pdb:4GUT|rcsb pdb:4GUU|rcsb pdb:4HSU|rcsb pdb:6R1U|rcsb pdb:6R25|refseq:XP_011521019.1|refseq:NP_001295025.1|refseq:NP_115958.2|refseq:NP_001311026.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:QsJhkB7Klk8D2R03vqPZzbi3f9g9606	rigid:mXcdX271J1iAE9/SAfggOmlMgiA	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q96N16	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-2680803|uniprotkb:A6H2J5|uniprotkb:A6H2J4|uniprotkb:B8ZZR7|uniprotkb:Q8N7G3|uniprotkb:A6H2J2|uniprotkb:A6H2J3|uniprotkb:Q86Y69|uniprotkb:A8MTK6|intact:EBI-2812508|uniprotkb:D3DVT0|ensembl:ENSP00000282924|ensembl:ENSP00000386925|uniprotkb:B4DHZ8	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:jkip1_human(display_long)|uniprotkb:GABABRBP(gene name synonym)|uniprotkb:JAMIP1(gene name synonym)|uniprotkb:MARLIN1(gene name synonym)|uniprotkb:GABA-B receptor-binding protein(gene name synonym)|uniprotkb:Multiple alpha-helices and RNA-linker protein 1(gene name synonym)|uniprotkb:JAKMIP1(gene name)|psi-mi:JAKMIP1(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510620|imex:IM-28561-1371	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_001293062.1|refseq:NP_001293063.1|refseq:XP_011511702.1|refseq:NP_001092903.1|refseq:NP_653321.1|ensembl:ENSG00000152969(gene)|ensembl:ENST00000282924(transcript)|ensembl:ENST00000409831(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0008017"(microtubule binding)|go:"GO:0015031"(protein transport)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019900"(kinase binding)|go:"GO:0050811"(GABA receptor binding)|go:"GO:0050890"(cognition)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR024836|interpro:IPR031994|mint:Q96N16|refseq:XP_016863282.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:tqQJu7pAUKeq6SOKhVJKm2u02mY9606	rigid:8oRlX7mDRZQdj4OKS1J11GNt078	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:P35579	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-350338|uniprotkb:O60805|ensembl:ENSP00000216181|uniprotkb:Q86T83|intact:EBI-1054343|uniprotkb:A8K6E4|uniprotkb:Q60FE2	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:myh9_human(display_long)|uniprotkb:MYH9(gene name)|psi-mi:MYH9(display_short)|uniprotkb:Myosin heavy chain 9(gene name synonym)|uniprotkb:Myosin heavy chain, non-muscle IIa(gene name synonym)|uniprotkb:Non-muscle myosin heavy chain IIa(gene name synonym)|uniprotkb:Cellular myosin heavy chain, type A(gene name synonym)|uniprotkb:Non-muscle myosin heavy chain A(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510835|imex:IM-28561-1127	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_002464.1|ensembl:ENSG00000100345(gene)|ensembl:ENST00000216181(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0001525"(angiogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0001768"(establishment of T cell polarity)|go:"GO:0001772"(immunological synapse)|go:"GO:0001778"(plasma membrane repair)|go:"GO:0001931"(uropod)|go:"GO:0003723"(RNA binding)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0003779"(actin binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005826"(actomyosin contractile ring)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007520"(myoblast fusion)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015031"(protein transport)|refseq:XP_011528499.1|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016460"(myosin II complex)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030220"(platelet formation)|go:"GO:0030224"(monocyte differentiation)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0031252"(cell leading edge)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032418"(lysosome localization)|go:"GO:0032506"(cytokinetic process)|go:"GO:0032796"(uropod organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0043531"(ADP binding)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045296"(cadherin binding)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051015"(actin filament binding)|go:"GO:0051295"(establishment of meiotic spindle localization)|go:"GO:0060471"(cortical granule exocytosis)|go:"GO:0060473"(cortical granule)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0097513"(myosin II filament)|go:"GO:1903919"(negative regulation of actin filament severing)|rcsb pdb:4CFR|rcsb pdb:4ETO|reactome:R-HSA-1445148|reactome:R-HSA-2029482|reactome:R-HSA-3928663|reactome:R-HSA-416572|reactome:R-HSA-5625740|reactome:R-HSA-5625900|reactome:R-HSA-5627117|reactome:R-HSA-5627123|reactome:R-HSA-9662360|reactome:R-HSA-9662361|reactome:R-HSA-9662834|reactome:R-HSA-9664422|go:"GO:1903923"(positive regulation of protein processing in phagocytic vesicle)|go:"GO:1905684"(regulation of plasma membrane repair)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR002928(Myosin tail)|interpro:IPR004009(Myosin, N-terminal, SH3-like)|interpro:IPR008989(Myosin S1 fragment, N-terminal)|interpro:IPR027417|interpro:IPR036305|interpro:IPR036961|mint:P35579|rcsb pdb:2LNK|rcsb pdb:3ZWH|rcsb pdb:4CFQ|refseq:XP_016884292.1|refseq:XP_016884293.1|refseq:XP_016884294.1|refseq:XP_016884295.1|dip:DIP-33103N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:fSOtpFpr8PSnAG5UdAr/khwkzJs9606	rigid:CwcDMzijxi2yrV5i3gaQ5N49k1s	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:P35580	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-351758|intact:EBI-7850240|intact:MINT-8330016|uniprotkb:B2RWP9|uniprotkb:D3DTS1|uniprotkb:Q9BWG0|uniprotkb:Q12989|uniprotkb:Q16087|uniprotkb:Q149N3|ensembl:ENSP00000269243|uniprotkb:Q149N4|uniprotkb:Q6PK16|uniprotkb:F8VTL3|uniprotkb:Q4LE45	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:myh10_human(display_long)|uniprotkb:MYH10(gene name)|psi-mi:MYH10(display_short)|uniprotkb:Myosin heavy chain 10(gene name synonym)|uniprotkb:Myosin heavy chain, non-muscle IIb(gene name synonym)|uniprotkb:Non-muscle myosin heavy chain IIb(gene name synonym)|uniprotkb:Cellular myosin heavy chain, type B(gene name synonym)|uniprotkb:Non-muscle myosin heavy chain B(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510826|imex:IM-28561-1383	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_001243024.1|refseq:NP_001242941.1|refseq:NP_005955.3|ensembl:ENSG00000133026(gene)|ensembl:ENST00000269243(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001725"(stress fiber)|go:"GO:0003779"(actin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005938"(cell cortex)|go:"GO:0007155"(cell adhesion)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016459"(myosin complex)|go:"GO:0016460"(myosin II complex)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030496"(midbody)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0032154"(cleavage furrow)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0042641"(actomyosin)|go:"GO:0043531"(ADP binding)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051015"(actin filament binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097513"(myosin II filament)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR002928(Myosin tail)|interpro:IPR004009(Myosin, N-terminal, SH3-like)|interpro:IPR008989(Myosin S1 fragment, N-terminal)|interpro:IPR027417|interpro:IPR036961|mint:P35580|rcsb pdb:4PD3|reactome:R-HSA-3928663|reactome:R-HSA-416572|reactome:R-HSA-5625740|reactome:R-HSA-5625900|reactome:R-HSA-5627117|reactome:R-HSA-5627123|refseq:XP_016880169.1|refseq:XP_016880170.1|refseq:XP_016880171.1|dip:DIP-31110N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:iSHfJZbrWg1L+vSpu1n7RmTTNN49606	rigid:uBpkui/5awRfyZRik5lYwh8lpAk	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:P20591	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-929476|uniprotkb:D3DSI8|uniprotkb:B2RDA5|uniprotkb:B3KU10|uniprotkb:C9IYV7|uniprotkb:C9J8D6|uniprotkb:C9JN19|uniprotkb:C9JN88|uniprotkb:C9JUL1|uniprotkb:C9JZS6|uniprotkb:Q86YP5|uniprotkb:Q96CI3|ensembl:ENSP00000381599|ensembl:ENSP00000381601|ensembl:ENSP00000392151|ensembl:ENSP00000402215|ensembl:ENSP00000408498|ensembl:ENSP00000410523|ensembl:ENSP00000505029|ensembl:ENSP00000505047|ensembl:ENSP00000505051|ensembl:ENSP00000505189|ensembl:ENSP00000505457|ensembl:ENSP00000505489|ensembl:ENSP00000505630|ensembl:ENSP00000505657|ensembl:ENSP00000505669|ensembl:ENSP00000505781|ensembl:ENSP00000505874|ensembl:ENSP00000506047|ensembl:ENSP00000506062|ensembl:ENSP00000506183|ensembl:ENSP00000506199|ensembl:ENSP00000506220|ensembl:ENSP00000506270|ensembl:ENSP00000506348|ensembl:ENSP00000506372|ensembl:ENSP00000506395|ensembl:ENSP00000506481|ensembl:ENSP00000506512|ensembl:ENSP00000506690|ensembl:ENSP00000506712	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:mx1_human(display_long)|uniprotkb:MX1(gene name)|psi-mi:MX1(display_short)|uniprotkb:Myxovirus resistance protein 1(gene name synonym)|uniprotkb:Interferon-regulated resistance GTP-binding protein MxA(gene name synonym)|uniprotkb:Interferon-induced protein p78(gene name synonym)|uniprotkb:Myxoma resistance protein 1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510819|imex:IM-28561-43	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_001269849.1|refseq:NP_001138397.1|refseq:NP_001171517.1|refseq:NP_002453.2|refseq:XP_011527870.1|refseq:XP_005261037.1|refseq:XP_005261038.1|refseq:XP_005261039.1|refseq:XP_005261035.1|refseq:XP_005261036.1|refseq:XP_016883838.1|refseq:XP_016883839.1|dip:DIP-35694N|ensembl:ENSG00000157601(gene)|ensembl:ENST00000398598(transcript)|ensembl:ENST00000398600(transcript)|ensembl:ENST00000413778(transcript)|ensembl:ENST00000417963(transcript)|ensembl:ENST00000419044(transcript)|ensembl:ENST00000455164(transcript)|ensembl:ENST00000679445(transcript)|ensembl:ENST00000679464(transcript)|ensembl:ENST00000679543(transcript)|ensembl:ENST00000679626(transcript)|ensembl:ENST00000679705(transcript)|ensembl:ENST00000679911(transcript)|ensembl:ENST00000680176(transcript)|ensembl:ENST00000680182(transcript)|ensembl:ENST00000680347(transcript)|ensembl:ENST00000680364(transcript)|ensembl:ENST00000680536(transcript)|ensembl:ENST00000680629(transcript)|ensembl:ENST00000680760(transcript)|ensembl:ENST00000680776(transcript)|ensembl:ENST00000681039(transcript)|ensembl:ENST00000681191(transcript)|ensembl:ENST00000681266(transcript)|ensembl:ENST00000681415(transcript)|ensembl:ENST00000681607(transcript)|ensembl:ENST00000681671(transcript)|ensembl:ENST00000681849(transcript)|ensembl:ENST00000681857(transcript)|ensembl:ENST00000681867(transcript)|ensembl:ENST00000681896(transcript)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0003374"(dynamin family protein polymerization involved in mitochondrial fission)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0008017"(microtubule binding)|go:"GO:0009615"(response to virus)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016185"(synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0030424"(axon)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031965"(nuclear membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034340"(response to type I interferon)|go:"GO:0042802"(identical protein binding)|go:"GO:0044327"(dendritic spine head)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0061025"(membrane fusion)|go:"GO:0070106"(interleukin-27-mediated signaling pathway)|go:"GO:0098793"(presynapse)|go:"GO:0098844"(postsynaptic endocytic zone membrane)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0140374"(antiviral innate immune response)|interpro:IPR000375(Dynamin central region)|interpro:IPR001401(Dynamin, GTPase region)|interpro:IPR003130(Dynamin GTPase effector)|interpro:IPR019762|interpro:IPR020850|interpro:IPR022812|interpro:IPR027417|interpro:IPR030381|mint:P20591|rcsb pdb:3LJB|rcsb pdb:3SZR|rcsb pdb:3ZYS|rcsb pdb:4P4S|rcsb pdb:4P4T|rcsb pdb:4P4U|rcsb pdb:5GTM|reactome:R-HSA-1169408|reactome:R-HSA-909733	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:9rO7Zyl6v0Kq3xw6MKbVefk1hCA9606	rigid:IUULEYRZU6Dr+qKe5Dt3kopfrNw	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q14764	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-2816254|uniprotkb:Q9BPW6|uniprotkb:Q9BQT1|uniprotkb:Q96BG4|uniprotkb:Q9UBD1|intact:EBI-28971732|ensembl:ENSP00000349977|ensembl:ENSP00000378760	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:mvp_human(display_long)|uniprotkb:MVP(gene name)|psi-mi:MVP(display_short)|uniprotkb:LRP(gene name synonym)|uniprotkb:Lung resistance-related protein(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510810|imex:IM-28561-909	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	ensembl:ENSP00000349977|ensembl:ENSP00000378760|refseq:NP_001280133.1|refseq:NP_001280134.1|refseq:NP_005106.2|refseq:NP_059447.2|ensembl:ENSG00000013364(gene)|ensembl:ENST00000357402(transcript)|ensembl:ENST00000395353(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005643"(nuclear pore)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051028"(mRNA transport)|go:"GO:0061099"(negative regulation of protein tyrosine kinase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002499(Major vault protein, N-terminal)|interpro:IPR021870|interpro:IPR036013|interpro:IPR039059|interpro:IPR040989|interpro:IPR041134|interpro:IPR041136|interpro:IPR041139|interpro:IPR043023|interpro:IPR043179|mint:Q14764|rcsb pdb:1Y7X|reactome:R-HSA-6798695	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:z/Hc6TeTzO5QSpZ8AUXiI2ox4eg9606	rigid:rljgYbiZ+/vbcjK9COZT4m+K23s	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q96BY2	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-739825|uniprotkb:Q9H833|uniprotkb:Q9HAS1|uniprotkb:B2RDF6|ensembl:ENSP00000298894|ensembl:ENSP00000451594|ensembl:ENSP00000482284|ensembl:ENSP00000486260	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:moap1_human(display_long)|uniprotkb:MOAP1(gene name)|psi-mi:MOAP1(display_short)|uniprotkb:PNMA4(gene name synonym)|uniprotkb:Paraneoplastic antigen Ma4(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510801|imex:IM-28561-1381	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_071434.2|ensembl:ENST00000627896(transcript)|go:"GO:0001844"(protein insertion into mitochondrial membrane involved in apoptotic signaling pathway)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|ensembl:ENSG00000165943(gene)|ensembl:ENSG00000278268(gene)|ensembl:ENST00000298894(transcript)|ensembl:ENST00000556883(transcript)|ensembl:ENST00000616515(transcript)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR026523|mint:Q96BY2|go:"GO:0005829"(cytosol)|dip:DIP-49959N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:wQSSosC82m35M8s+YamN1i73wi49606	rigid:4oLrXzeY0lLLLeLqGlnfrVxAr18	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q13015	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-6269719|ensembl:ENSP00000357917	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:af1q_human(display_long)|uniprotkb:MLLT11(gene name)|psi-mi:MLLT11(display_short)|uniprotkb:AF1Q(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510794|imex:IM-28561-457	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	ensembl:ENSG00000213190(gene)|ensembl:ENST00000368921(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR026778|interpro:IPR033461|mint:Q13015|refseq:NP_006809.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:23mnJAG1OcDgM7eT2rTi1Gv0ZgA9606	rigid:X7vMol/um60IKIImngcxkalbJ6Y	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q96EZ8	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-348259|ensembl:ENSP00000345358|ensembl:ENSP00000448056|uniprotkb:O14742|uniprotkb:O75497|uniprotkb:Q6VN53|uniprotkb:Q7Z372	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:mcrs1_human(display_long)|uniprotkb:MCRS1(gene name)|psi-mi:MCRS1(display_short)|uniprotkb:MSP58(gene name synonym)|uniprotkb:58 kDa microspherule protein(gene name synonym)|uniprotkb:Cell cycle-regulated factor p78(gene name synonym)|uniprotkb:MCRS2(gene name synonym)|uniprotkb:INO80Q(gene name synonym)|uniprotkb:INO80 complex subunit J(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510787|imex:IM-28561-1125	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	ensembl:ENSG00000187778(gene)|ensembl:ENST00000343810(transcript)|ensembl:ENST00000550165(transcript)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005844"(polysome)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0010521"(telomerase inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0031011"(Ino80 complex)|go:"GO:0034046"("poly(G) binding")|go:"GO:0043204"(perikaryon)|go:"GO:0043981"(histone H4-K5 acetylation)|go:"GO:0043982"(histone H4-K8 acetylation)|go:"GO:0044545"(NSL complex)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0071339"(MLL1 complex)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1904751"(positive regulation of protein localization to nucleolus)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR025999|interpro:IPR037912|mint:Q96EZ8|reactome:R-HSA-3214847|go:"GO:0043984"(histone H4-K16 acetylation)|reactome:R-HSA-5689603|reactome:R-HSA-5696394|refseq:NP_001012300.1|refseq:NP_006328.2|refseq:NP_001265270.1|refseq:XP_005268629.1|refseq:XP_016874178.1|refseq:XP_016874179.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:b6u2XbKLMDkL1zbLTPBjq9J23Zs9606	rigid:zG/n6OzW8ZCzRQ+MhRE9AQLnEfA	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q9NS73	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-741953|uniprotkb:Q86TZ2|uniprotkb:Q96AS5|uniprotkb:Q9BS93|uniprotkb:Q9NZE1|ensembl:ENSP00000399718	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:mbip1_human(display_long)|uniprotkb:MAPK upstream kinase-binding inhibitory protein(gene name synonym)|uniprotkb:MBIP(gene name)|psi-mi:MBIP(display_short)|uniprotkb:BM-015(orf name)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510780|imex:IM-28561-1379	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_001138363.1|refseq:NP_057670.2|ensembl:ENSG00000151332(gene)|ensembl:ENST00000416007(transcript)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005671"(obsolete Ada2/Gcn5/Ada3 transcription activator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0042802"(identical protein binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0046330"(positive regulation of JNK cascade)|interpro:IPR026062|mint:Q9NS73|reactome:R-HSA-3214847|go:"GO:0005654"(nucleoplasm)|refseq:NP_001295039.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:PjaEuab6wwOyGImpNYFZfQ+TUvU9606	rigid:wNI10H2/tibHrs5PW0vjCOxBibo	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:O60336	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-947402|uniprotkb:A8K8P9|uniprotkb:Q14CB5|uniprotkb:Q14CD8|uniprotkb:Q5W9G9|uniprotkb:Q49AJ8|uniprotkb:A6NM93|ensembl:ENSP00000393099	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:mabp1_human(display_long)|uniprotkb:MAPKBP1(gene name)|psi-mi:MAPKBP1(display_short)|uniprotkb:JNKBP1(gene name synonym)|uniprotkb:KIAA0596(gene name synonym)|uniprotkb:JNK-binding protein 1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510771|imex:IM-28561-1605	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_001122080.1|refseq:NP_055809.2|refseq:NP_001252540.1|ensembl:ENSG00000137802(gene)|ensembl:ENST00000456763(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:1900425"(negative regulation of defense response to bacterium)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|mint:O60336	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:7o2Pxm1NiSuV7txoMpcismKbn/s9606	rigid:W+7FdRQg3qgfLC176uO+ZAjsnGU	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q9UPT6	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-717887|uniprotkb:A2A2B3|uniprotkb:Q96RY4|uniprotkb:Q9H4I4|uniprotkb:Q9H7P1|uniprotkb:Q9NUG0|uniprotkb:A7E2B3|ensembl:ENSP00000250894	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:jip3_human(display_long)|uniprotkb:JNK MAP kinase scaffold protein 3(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 8-interacting protein 3(gene name synonym)|uniprotkb:JIP3(gene name synonym)|uniprotkb:KIAA1066(gene name synonym)|uniprotkb:MAPK8IP3(gene name)|psi-mi:MAPK8IP3(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510762|imex:IM-28561-907	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_001035529.1|refseq:NP_055948.2|refseq:NP_001305781.1|ensembl:ENSG00000138834(gene)|ensembl:ENST00000250894(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019894"(kinesin binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031103"(axon regeneration)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0044297"(cell body)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061564"(axon development)|go:"GO:0099641"(anterograde axonal protein transport)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019143|interpro:IPR032486|interpro:IPR034743|interpro:IPR034744|interpro:IPR036322|interpro:IPR039911|mint:Q9UPT6|rcsb pdb:4PXJ|go:"GO:1904115"(axon cytoplasm)	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:PIL9w/kseAImo5TJWUxoTzlUjMg9606	rigid:Ned4cWVM4Ankp7wTHmXsfaSUE5c	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q13164	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-1213983|uniprotkb:Q16634|uniprotkb:Q59F50|uniprotkb:Q6QLU7|uniprotkb:Q7L4P4|uniprotkb:Q969G1|uniprotkb:Q96G51|intact:EBI-28979986|ensembl:ENSP00000311005|ensembl:ENSP00000378966|ensembl:ENSP00000378968	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:mk07_human(display_long)|uniprotkb:MAPK7(gene name)|psi-mi:MAPK7(display_short)|uniprotkb:BMK1(gene name synonym)|uniprotkb:ERK5(gene name synonym)|uniprotkb:PRKM7(gene name synonym)|uniprotkb:Extracellular signal-regulated kinase 5(gene name synonym)|uniprotkb:Big MAP kinase 1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510755|imex:IM-28561-1377	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_002740.2|refseq:NP_620601.1|refseq:NP_620602.2|refseq:NP_620603.2|ensembl:ENST00000299612|ensembl:ENSP00000299612|ensembl:ENSP00000311005|ensembl:ENSP00000378966|ensembl:ENSP00000378968|refseq:XP_011522259.1|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0051344"(negative regulation of cyclic-nucleotide phosphodiesterase activity)|go:"GO:0060761"(negative regulation of response to cytokine stimulus)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071499"(cellular response to laminar fluid shear stress)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q13164|rcsb pdb:2Q8Y|rcsb pdb:4B99|rcsb pdb:4IC7|rcsb pdb:4IC8|rcsb pdb:4ZSG|rcsb pdb:4ZSJ|rcsb pdb:4ZSL|rcsb pdb:5BYY|rcsb pdb:5BYZ|rcsb pdb:5O7I|rcsb pdb:6HKM|rcsb pdb:6HKN|reactome:R-HSA-198753|reactome:R-HSA-198765|reactome:R-HSA-202670|reactome:R-HSA-2559582|reactome:R-HSA-881907|reactome:R-HSA-8853659|ensembl:ENSG00000166484(gene)|ensembl:ENST00000308406(transcript)|ensembl:ENST00000395602(transcript)|ensembl:ENST00000395604(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0030154"(cell differentiation)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:dUTMnlgdjEkFhq0i6RmvpX5U7BM9606	rigid:vTKSMyKrm13IxjEKqZW68skTeSI	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q9Y5V3	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-716006|uniprotkb:Q5VSH6|uniprotkb:Q8IZ84|uniprotkb:Q8WY92|uniprotkb:Q9H352|uniprotkb:Q9HBT4|uniprotkb:Q9UF36|ensembl:ENSP00000325333|ensembl:ENSP00000364874|ensembl:ENSP00000364927	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:magd1_human(display_long)|uniprotkb:MAGE-D1 antigen(gene name synonym)|uniprotkb:Neurotrophin receptor-interacting MAGE homolog(gene name synonym)|uniprotkb:MAGE tumor antigen CCF(gene name synonym)|uniprotkb:MAGED1(gene name)|psi-mi:MAGED1(display_short)|uniprotkb:NRAGE(gene name synonym)|uniprotkb:PRO2292(orf name)|uniprotkb:PP2250(orf name)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510746|imex:IM-28561-699	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_001005332.1|refseq:NP_001005333.1|refseq:NP_008917.3|ensembl:ENSP00000325333|ensembl:ENST00000375695|ensembl:ENSP00000364847|ensembl:ENSP00000364874|ensembl:ENSP00000364927|refseq:XP_011529137.1|refseq:XP_016885467.1|refseq:XP_016885468.1|refseq:XP_016885469.1|ensembl:ENSG00000179222(gene)|ensembl:ENST00000326587(transcript)|ensembl:ENST00000375722(transcript)|ensembl:ENST00000375772(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR002190(MAGE protein)|interpro:IPR030083|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|mint:Q9Y5V3|reactome:R-HSA-193648|reactome:R-HSA-418889	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:UTg0r4zGMXfTZqBN4SFmgu6IukI9606	rigid:o0whj9tD4HYP85J9nsQWdyPABW0	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q9Y6D9	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-742610|uniprotkb:B3KR41|uniprotkb:Q9UNH0|uniprotkb:Q13312|uniprotkb:Q75MI0|uniprotkb:Q86UM4|ensembl:ENSP00000265854|ensembl:ENSP00000382562|ensembl:ENSP00000385334	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:md1l1_human(display_long)|uniprotkb:Mitotic arrest deficient 1-like protein 1(gene name synonym)|uniprotkb:Mitotic checkpoint MAD1 protein homolog(gene name synonym)|uniprotkb:Tax-binding protein 181(gene name synonym)|uniprotkb:MAD1L1(gene name)|psi-mi:MAD1L1(display_short)|uniprotkb:MAD1(gene name synonym)|uniprotkb:TXBP181(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510739|imex:IM-28561-697	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_001013858.1|refseq:NP_001013859.1|refseq:NP_003541.2|refseq:NP_001291452.1|refseq:NP_001291453.1|ensembl:ENSG00000002822(gene)|ensembl:ENST00000265854(transcript)|go:"GO:0090235"(regulation of metaphase plate congression)|go:"GO:1902426"(deactivation of mitotic spindle assembly checkpoint)|interpro:IPR008672(Mitotic checkpoint)|mint:Q9Y6D9|rcsb pdb:1GO4|rcsb pdb:4DZO|rcsb pdb:7B1F|rcsb pdb:7B1H|rcsb pdb:7B1J|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|ensembl:ENST00000399654(transcript)|ensembl:ENST00000406869(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043515"(kinetochore binding)|go:"GO:0044615"(nuclear pore nuclear basket)|go:"GO:0048538"(thymus development)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0051301"(cell division)|go:"GO:0051315"(attachment of mitotic spindle microtubules to kinetochore)|go:"GO:0072686"(mitotic spindle)|refseq:XP_005249934.1|dip:DIP-29654N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:9CcqpZlN0IgqC939rIo7vNgOvLQ9606	rigid:PE7WYWq1rdJsWdyNdyyOs32slkg	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q9BRK4	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-741037|ensembl:ENSP00000359240|ensembl:ENSP00000359243|uniprotkb:Q8N3I0|uniprotkb:Q96J79|uniprotkb:Q96JL2|uniprotkb:B1AL14|uniprotkb:D3DR72	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:lzts2_human(display_long)|uniprotkb:Protein LAPSER1(gene name synonym)|uniprotkb:LZTS2(gene name)|psi-mi:LZTS2(display_short)|uniprotkb:KIAA1813(gene name synonym)|uniprotkb:LAPSER1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510730|imex:IM-28561-245	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_115805.1|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030496"(midbody)|go:"GO:0031982"(vesicle)|go:"GO:0051013"(microtubule severing)|go:"GO:0051168"(nuclear export)|go:"GO:0051255"(spindle midzone assembly)|go:"GO:0060682"(primary ureteric bud growth)|go:"GO:0072197"(ureter morphogenesis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|interpro:IPR028597|mint:Q9BRK4|ensembl:ENSG00000107816(gene)|ensembl:ENST00000370220(transcript)|ensembl:ENST00000370223(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0008285"(negative regulation of cell population proliferation)|refseq:XP_016872269.1|refseq:NP_001305028.1|refseq:NP_001305029.1|refseq:NP_001305030.1|refseq:XP_005270279.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:OaMJmnmfm6JniKUJeyg7fS6zRcw9606	rigid:nBM8AEKDWhr/frxt+FkH0vv8Em8	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q9Y383	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-352851|ensembl:ENSP00000347005|uniprotkb:Q8IUP9|uniprotkb:Q9NVL3|uniprotkb:Q9NVN7|uniprotkb:Q9UQN1|uniprotkb:B7Z500	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:lc7l2_human(display_long)|uniprotkb:LUC7L2(gene name)|psi-mi:LUC7L2(display_short)|uniprotkb:CGI-59(orf name)|uniprotkb:CGI-74(orf name)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510723|imex:IM-28561-905	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	ensembl:ENSG00000146963(gene)|ensembl:ENST00000354926(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005685"(U1 snRNP)|go:"GO:0006376"(mRNA splice site selection)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0071004"(U2-type prespliceosome)|interpro:IPR004882(LUC7 related)|mint:Q9Y383|refseq:NP_057103.2|refseq:NP_001231514.1|refseq:NP_001257572.1|dip:DIP-32513N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:WLp3u1YbXtdPGzIm6WxvAbrQKhM9606	rigid:hIXwk3a+n8LHeCX2CaROAHLnFrg	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q6UWE0	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-720984|uniprotkb:Q5VVV0|uniprotkb:Q8NB40|uniprotkb:Q96GT5|uniprotkb:Q96MX5|uniprotkb:Q96MZ7|ensembl:ENSP00000300417|ensembl:ENSP00000322937|ensembl:ENSP00000362419|ensembl:ENSP00000502167	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:lrsm1_human(display_long)|uniprotkb:Leucine-rich repeat and sterile alpha motif-containing protein 1(gene name synonym)|uniprotkb:Tsg101-associated ligase(gene name synonym)|uniprotkb:LRSAM1(gene name)|psi-mi:LRSAM1(display_short)|uniprotkb:TAL(gene name synonym)|uniprotkb:UNQ6496/PRO21356(orf name)|uniprotkb:RING-type E3 ubiquitin transferase LRSAM1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510714|imex:IM-28561-455	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_001005373.1|refseq:NP_001005374.1|refseq:NP_001177652.1|refseq:NP_612370.3|refseq:XP_016870772.1|ensembl:ENSG00000148356(gene)|ensembl:ENST00000300417(transcript)|ensembl:ENST00000323301(transcript)|ensembl:ENST00000373322(transcript)|ensembl:ENST00000675448(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030163"(protein catabolic process)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0046755"(viral budding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070086"(ubiquitin-dependent endocytosis)|go:"GO:1904417"(positive regulation of xenophagy)|go:"GO:2000786"(positive regulation of autophagosome assembly)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032675|mint:Q6UWE0|reactome:R-HSA-983168	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:qkwPqOsfNjZBB2Xp6YAA9FbEZxM9606	rigid:AFmrLiC/uJ4/VZ0qokpWmCQn79s	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:P28838	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-2339312|uniprotkb:Q6IAM6|uniprotkb:Q6P0L6|uniprotkb:Q9UQE3|uniprotkb:B3KMQ3|ensembl:ENSP00000226299|ensembl:ENSP00000481000	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:ampl_human(display_long)|uniprotkb:LAP3(gene name)|psi-mi:LAP3(display_short)|uniprotkb:LAPEP(gene name synonym)|uniprotkb:PEPS(gene name synonym)|uniprotkb:Leucyl aminopeptidase(gene name synonym)|uniprotkb:Leucine aminopeptidase 3(gene name synonym)|uniprotkb:Proline aminopeptidase(gene name synonym)|uniprotkb:Prolyl aminopeptidase(gene name synonym)|uniprotkb:Peptidase S(gene name synonym)|uniprotkb:Cysteinylglycine-S-conjugate dipeptidase(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510707|imex:IM-28561-41	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_056991.2|ensembl:ENSG00000002549(gene)|ensembl:ENST00000226299(transcript)|ensembl:ENST00000618908(transcript)|go:"GO:0004177"(aminopeptidase activity)|go:"GO:0004180"(carboxypeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0008235"(metalloexopeptidase activity)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030496"(midbody)|go:"GO:0070006"(metalloaminopeptidase activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000819(Peptidase M17, leucyl aminopeptidase, C-terminal)|interpro:IPR008283(Peptidase M17, leucyl aminopeptidase, N-terminal)|interpro:IPR011356(Peptidase M17, leucyl aminopeptidase)|interpro:IPR023042|interpro:IPR043472|mint:P28838	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:BGEwM09Jm/Nn1CwI+QguAqIwGzw9606	rigid:b/fbbPmymTQgKrH0YNkajb6ZIPE	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:P05783	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-297888|uniprotkb:Q53G38|uniprotkb:Q5U0N8|uniprotkb:Q9BW26|ensembl:ENSP00000373487|ensembl:ENSP00000373489	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:k1c18_human(display_long)|uniprotkb:KRT18(gene name)|psi-mi:KRT18(display_short)|uniprotkb:CYK18(gene name synonym)|uniprotkb:Keratin-18(gene name synonym)|uniprotkb:PIG46(orf name)|uniprotkb:Cytokeratin-18(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 46 protein(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510698|imex:IM-28561-39	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0005912"(adherens junction)|go:"GO:0007049"(cell cycle)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009750"(response to fructose)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034451"(centriolar satellite)|go:"GO:0043000"(Golgi to plasma membrane CFTR protein transport)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045095"(keratin filament)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070365"(hepatocyte differentiation)|go:"GO:0072497"(mesenchymal stem cell differentiation)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:1902488"(cholangiocyte apoptotic process)|interpro:IPR002957(Keratin, type I)|interpro:IPR018039|interpro:IPR027695|interpro:IPR039008|mint:P05783|reactome:R-HSA-6805567|reactome:R-HSA-6809371|ensembl:ENSG00000111057(gene)|ensembl:ENST00000388835(transcript)|ensembl:ENST00000388837(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|refseq:NP_000215.1|refseq:NP_954657.1|dip:DIP-633N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:6rtLZxuG0CSGcsCHEmkRKFVDeyo9606	rigid:X1T0TGAPSisergkTPOiWIUvba7c	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q9P2E2	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-949612|ensembl:ENSP00000247986|uniprotkb:O95077|uniprotkb:Q53YS6|uniprotkb:Q5VWA9|uniprotkb:Q6GSA8|uniprotkb:Q8N411|uniprotkb:A2A3Q7|uniprotkb:A2A3Q8	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:kif17_human(display_long)|uniprotkb:KIF3-related motor protein(gene name synonym)|uniprotkb:KIF17(gene name)|psi-mi:KIF17(display_short)|uniprotkb:KIAA1405(gene name synonym)|uniprotkb:KIF3X(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510691|imex:IM-28561-1123	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	ensembl:ENSG00000117245(gene)|ensembl:ENST00000247986(transcript)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0005929"(cilium)|go:"GO:0005930"(axoneme)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0008017"(microtubule binding)|go:"GO:0008574"(plus-end-directed microtubule motor activity)|go:"GO:0015031"(protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030030"(cell projection organization)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043005"(neuron projection)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0098971"(anterograde dendritic transport of neurotransmitter receptor complex)|go:"GO:1990075"(periciliary membrane compartment)|interpro:IPR001752(Kinesin, motor region)|interpro:IPR019821|interpro:IPR027417|interpro:IPR027640|interpro:IPR036961|mint:Q9P2E2|reactome:R-HSA-5620924|reactome:R-HSA-9609736|refseq:NP_001116291.1|refseq:NP_065867.2|refseq:NP_001274141.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:EXTRC6rf1yPUFuLt/b+qqt8tSpM9606	rigid:bWhjg/FJIeR1TbcgnrT5sWqI0xk	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q8N163	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-355410|uniprotkb:A6NL03|uniprotkb:Q6P0Q9|uniprotkb:Q8N3G7|uniprotkb:Q8N8M1|uniprotkb:Q8TF34|uniprotkb:Q9H9Q9|uniprotkb:Q9HD12|uniprotkb:Q9NT55|ensembl:ENSP00000310670|ensembl:ENSP00000373930|uniprotkb:B2RB79|uniprotkb:D3DSR6	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:ccar2_human(display_long)|uniprotkb:CCAR2(gene name)|psi-mi:CCAR2(display_short)|uniprotkb:Cell division cycle and apoptosis regulator protein 2(gene name synonym)|uniprotkb:DBC1(gene name synonym)|uniprotkb:DBIRD complex subunit KIAA1967(gene name synonym)|uniprotkb:Deleted in breast cancer gene 1 protein(gene name synonym)|uniprotkb:KIAA1967(gene name synonym)|uniprotkb:p30 DBC(gene name synonym)|uniprotkb:NET35(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510682|imex:IM-28561-1121	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_066997.3|ensembl:ENSG00000158941(gene)|ensembl:ENST00000308511(transcript)|ensembl:ENST00000389279(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005819"(spindle)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0008380"(RNA splicing)|go:"GO:0009411"(response to UV)|go:"GO:0016055"(Wnt signaling pathway)|interpro:IPR028811|mint:Q8N163|reactome:R-HSA-3371453|go:"GO:0019899"(enzyme binding)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032784"(regulation of DNA-templated transcription, elongation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0044609"(DBIRD complex)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048511"(rhythmic process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090311"(regulation of protein deacetylation)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:2000003"(positive regulation of DNA damage checkpoint)|interpro:IPR011992(EF-Hand type)|interpro:IPR025223|interpro:IPR025224|interpro:IPR025954|dip:DIP-38122N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:GL+fD8W0kadrYrBkuMqoKgbbITU9606	rigid:aquyF3cghJ0F0XOhkd0Xn+7wOuk	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q674X7	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-949239|uniprotkb:B0QYQ0|uniprotkb:B1AK78|uniprotkb:Q5TGF1|uniprotkb:Q674X6|uniprotkb:Q6ZUD1|uniprotkb:Q8IYN7|uniprotkb:Q8N409|uniprotkb:Q9UIL2|uniprotkb:Q674X4|ensembl:ENSP00000365198|uniprotkb:Q9UPX4|uniprotkb:B1AJZ1	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:kazrn_human(display_long)|uniprotkb:KIAA1026(gene name synonym)|uniprotkb:HRIHFB2003(orf name)|uniprotkb:KAZN(gene name)|psi-mi:KAZN(display_short)|uniprotkb:KAZ(gene name synonym)|uniprotkb:C1orf196(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510675|imex:IM-28561-695	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	ensembl:ENSG00000189337(gene)|ensembl:ENST00000376030(transcript)|go:"GO:0001533"(cornified envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0016607"(nuclear speck)|go:"GO:0030057"(desmosome)|go:"GO:0031424"(keratinization)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR037613|interpro:IPR037614|interpro:IPR037615|interpro:IPR037616|mint:Q674X7|reactome:R-HSA-6809371|refseq:NP_001017999.1|refseq:NP_001018000.1|refseq:NP_001018001.1|refseq:NP_056024.1|refseq:NP_963922.2|refseq:XP_016856260.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:Ai9moSFrBZMcWm4XWkk/vGzD5yE9606	rigid:Mm9ePCPH1uv6gB0NUFj2L/3A6gQ	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q5JR59	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-742948|ensembl:ENSP00000483729|uniprotkb:O94872|uniprotkb:Q08E97|uniprotkb:Q5JQR3|uniprotkb:Q8N5E2|uniprotkb:B4DF81|uniprotkb:A7E292	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:mtus2_human(display_long)|uniprotkb:TIP150(gene name synonym)|uniprotkb:MTUS2(gene name)|psi-mi:MTUS2(display_short)|uniprotkb:CAZIP(gene name synonym)|uniprotkb:KIAA0774(gene name synonym)|uniprotkb:Microtubule plus-end tracking protein TIP150(gene name synonym)|uniprotkb:Cardiac zipper protein(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26510668|imex:IM-28561-1375	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_001028774.2|refseq:NP_056048.1|ensembl:ENSG00000132938(gene)|ensembl:ENST00000612955(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0008017"(microtubule binding)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR033339|mint:Q5JR59|ensembl:ENST00000380808|ensembl:ENSP00000370186|ensembl:ENST00000542829|ensembl:ENSP00000445403|ensembl:ENSP00000483729	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:mC6V+TBEtOpFLeNXq09unF0p6N49606	rigid:zoQMeQdHM9gJVongjw7qsAPE3zs	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q8NEY8	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-474076|uniprotkb:Q86YT2|uniprotkb:Q8IXN3|uniprotkb:Q8TB09|uniprotkb:Q96NB9|uniprotkb:Q9NXL4|uniprotkb:Q9P0P6|uniprotkb:Q9P0R9|uniprotkb:E9PAX8|ensembl:ENSP00000378935|ensembl:ENSP00000479913	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:pphln_human(display_long)|uniprotkb:Gastric cancer antigen Ga50(gene name synonym)|uniprotkb:HSPC206(orf name)|uniprotkb:HSPC232(orf name)|uniprotkb:PPHLN1(gene name)|psi-mi:PPHLN1(display_short)|uniprotkb:CDC7 expression repressor(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511036|imex:IM-28561-961	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_001137259.1|refseq:NP_001137260.1|refseq:NP_057572.5|refseq:NP_958846.1|refseq:NP_958847.1|refseq:NP_958848.1|refseq:NP_958923.1|dip:DIP-49051N|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0031424"(keratinization)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0090309"(positive regulation of DNA methylation-dependent heterochromatin assembly)|go:"GO:0097355"(protein localization to heterochromatin)|interpro:IPR028851|mint:Q8NEY8|rcsb pdb:6SWG|ensembl:ENSG00000134283(gene)|ensembl:ENST00000395568(transcript)|ensembl:ENST00000610488(transcript)	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:+s8KstGQ7d91qe3DDnpKYMJon7o9606	rigid:Kn2alG5ya4YgD4U3bRySYXTn698	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q8ND90	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-302345|uniprotkb:O95144|uniprotkb:Q8NG07|ensembl:ENSP00000318914|uniprotkb:A8K4L5	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:pnma1_human(display_long)|uniprotkb:PNMA1(gene name)|psi-mi:PNMA1(display_short)|uniprotkb:MA1(gene name synonym)|uniprotkb:Neuron- and testis-specific protein 1(gene name synonym)|uniprotkb:37 kDa neuronal protein(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511027|imex:IM-28561-525	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_006020.4|ensembl:ENSG00000176903(gene)|ensembl:ENST00000316836(transcript)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0043065"(positive regulation of apoptotic process)|interpro:IPR026523|interpro:IPR026528|mint:Q8ND90	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:/lx3CB7d/dv4xIgWQrCETPA0Qcw9606	rigid:tEpdiMB1D69X0MdsiH6H8uSTA88	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q9BZL4	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-721802|uniprotkb:Q59FK8|uniprotkb:Q6ZPD1|uniprotkb:Q7L8F7|uniprotkb:Q9H5H5|uniprotkb:Q9NT00|uniprotkb:Q96HW1|uniprotkb:B4DME2|ensembl:ENSP00000263433	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:pp12c_human(display_long)|uniprotkb:LENG3(gene name synonym)|uniprotkb:MBS85(gene name synonym)|uniprotkb:Protein phosphatase 1 myosin-binding subunit of 85 kDa(gene name synonym)|uniprotkb:PPP1R12C(gene name)|psi-mi:PPP1R12C(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511045|imex:IM-28561-283	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_060077.1|refseq:NP_001258547.1|refseq:XP_005259070.1|ensembl:ENSG00000125503(gene)|ensembl:ENST00000263433(transcript)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007165"(signal transduction)|go:"GO:0019208"(phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|interpro:IPR002110(Ankyrin)|interpro:IPR017401(Protein phosphatase 1, regulatory subunits 12A/B/C, eukaryote)|interpro:IPR020683|interpro:IPR031205|interpro:IPR031775|interpro:IPR036770|mint:Q9BZL4	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:q24mbt02IydCWtQyNXmNVWav/i89606	rigid:5qGTM1QiepzuUmA64cN7f6rANtE	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:P14314	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-716953|uniprotkb:Q96BU9|uniprotkb:Q96D06|uniprotkb:Q9P0W9|uniprotkb:A8K318|ensembl:ENSP00000465461	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:glu2b_human(display_long)|uniprotkb:Glucosidase II subunit beta(gene name synonym)|uniprotkb:Protein kinase C substrate 60.1 kDa protein heavy chain(gene name synonym)|uniprotkb:80K-H protein(gene name synonym)|uniprotkb:PRKCSH(gene name)|psi-mi:PRKCSH(display_short)|uniprotkb:G19P1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511054|imex:IM-28561-527	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_001001329.1|refseq:NP_002734.2|refseq:XP_011526433.1|refseq:XP_011526434.1|refseq:NP_001276031.1|ensembl:ENSG00000130175(gene)|ensembl:ENST00000589838(transcript)|go:"GO:0001889"(liver development)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006491"(N-glycan processing)|go:"GO:0017177"(glucosidase II complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0051219"(phosphoprotein binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR009011(Mannose-6-phosphate receptor, binding)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR028146|interpro:IPR036055|interpro:IPR036607|interpro:IPR039794|interpro:IPR044865|mint:P14314|reactome:R-HSA-381426|reactome:R-HSA-532668|reactome:R-HSA-879415|reactome:R-HSA-8957275|reactome:R-HSA-901042|reactome:R-HSA-9683686|reactome:R-HSA-9694548|refseq:XP_016882466.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:hs2AZthZKK6KVW8Blm1RuZVh1QM9606	rigid:hHjR+tzRiEtU2ZBCUqASnPydJoQ	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q99873	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-78738|intact:EBI-949313|uniprotkb:A0A087X1W2|uniprotkb:H7C2I1|uniprotkb:Q15529|uniprotkb:Q99872|uniprotkb:Q99874|uniprotkb:Q9NZ04|uniprotkb:Q9NZ05|uniprotkb:Q9NZ06|ensembl:ENSP00000406162|intact:EBI-2622582|uniprotkb:B4E3C3|uniprotkb:G5E9B6|uniprotkb:Q8WUW5|uniprotkb:Q2VP93|uniprotkb:Q6LEU5|intact:EBI-11034520|intact:EBI-6137914	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:anm1_human(display_long)|uniprotkb:PRMT1(gene name)|psi-mi:PRMT1(display_short)|uniprotkb:Interferon receptor 1-bound protein 4(gene name synonym)|uniprotkb:Histone-arginine N-methyltransferase PRMT1(gene name synonym)|uniprotkb:HMT2(gene name synonym)|uniprotkb:HRMT1L2(gene name synonym)|uniprotkb:IR1B4(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511061|imex:IM-28561-1163	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	ensembl:ENSG00000126457(gene)|ensembl:ENST00000454376(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006479"(protein methylation)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0008170"(N-methyltransferase activity)|go:"GO:0008276"(protein methyltransferase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0016274"(protein-arginine N-methyltransferase activity)|go:"GO:0016571"(histone methylation)|go:"GO:0018216"(peptidyl-arginine methylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0034709"(methylosome)|go:"GO:0035241"(protein-arginine omega-N monomethyltransferase activity)|go:"GO:0035242"(protein-arginine omega-N asymmetric methyltransferase activity)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043985"(histone H4-R3 methylation)|go:"GO:0044020"("histone methyltransferase activity (H4-R3 specific)")|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045652"(regulation of megakaryocyte differentiation)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0046985"(positive regulation of hemoglobin biosynthetic process)|go:"GO:0048273"(mitogen-activated protein kinase p38 binding)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0051260"(protein homooligomerization)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1904047"(S-adenosyl-L-methionine binding)|interpro:IPR025799|interpro:IPR029063|interpro:IPR041698|mint:Q99873|rcsb pdb:6NT2|reactome:R-HSA-3214858|reactome:R-HSA-6804114|reactome:R-HSA-8936459|reactome:R-HSA-9009391|reactome:R-HSA-9018519|refseq:NP_001527.3|refseq:NP_938074.2|refseq:XP_016882223.1|refseq:XP_016882224.1|refseq:NP_001193971.1|dip:DIP-30878N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:8I7isKQC9YJTBzPz1Qve4V8l8Xg9606	rigid:rgIWEs88Eg+MYG1K1XeFVUZrVbQ	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q9NZ81	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-740924|uniprotkb:Q0V8U0|uniprotkb:Q6FIG7|uniprotkb:Q6MZP8|uniprotkb:Q6NXQ6|uniprotkb:Q6PKF9|ensembl:ENSP00000412064|ensembl:ENSP00000447777|ensembl:ENSP00000448761	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:prr13_human(display_long)|uniprotkb:PRR13(gene name)|psi-mi:PRR13(display_short)|uniprotkb:BM-041(orf name)|uniprotkb:TXR1(gene name synonym)|uniprotkb:Taxane-resistance protein(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511068|imex:IM-28561-1165	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_001005354.1|refseq:NP_060927.1|ensembl:ENSG00000205352(gene)|ensembl:ENST00000429243(transcript)|ensembl:ENST00000549135(transcript)|ensembl:ENST00000549924(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|mint:Q9NZ81	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:HcPXN5SrvMwlmm3dvQ/535fid6U9606	rigid:AJCuubS76zMPEmK+YlZ7luqNJ00	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q96C36	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-358366|uniprotkb:Q7Z515|uniprotkb:Q9Y5J4|ensembl:ENSP00000342502|uniprotkb:A8K798	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:p5cr2_human(display_long)|uniprotkb:PYCR2(gene name)|psi-mi:PYCR2(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511129|imex:IM-28561-723	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_037460.2|ensembl:ENSG00000143811(gene)|ensembl:ENST00000343818(transcript)|go:"GO:0004735"(pyrroline-5-carboxylate reductase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006561"(proline biosynthetic process)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0055129"(L-proline biosynthetic process)|interpro:IPR000304(Delta 1-pyrroline-5-carboxylate reductase)|interpro:IPR008927(6-phosphogluconate dehydrogenase, C-terminal-like)|interpro:IPR028939|interpro:IPR029036|interpro:IPR036291|mint:Q96C36|rcsb pdb:6LHM|reactome:R-HSA-8964539|refseq:NP_001258610.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:lIjn88RdpxuNpN+fgVPZV2bjubA9606	rigid:DNSZv4qH3LeIwgghyY0d+ryQxVc	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:P32322	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-848624|uniprotkb:B4DMU0|uniprotkb:Q6FHI4|uniprotkb:Q96DI6|uniprotkb:A6NFM2|uniprotkb:Q9HBQ4|ensembl:ENSP00000328858|ensembl:ENSP00000479793	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:p5cr1_human(display_long)|uniprotkb:PYCR1(gene name)|psi-mi:PYCR1(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511120|imex:IM-28561-289	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_008838.2|refseq:XP_011521885.1|refseq:XP_011521886.1|refseq:NP_001269209.1|refseq:NP_001269210.1|refseq:XP_005256438.1|refseq:NP_722546.1|ensembl:ENSG00000183010(gene)|ensembl:ENST00000329875(transcript)|ensembl:ENST00000619204(transcript)|go:"GO:0004735"(pyrroline-5-carboxylate reductase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006561"(proline biosynthetic process)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0055129"(L-proline biosynthetic process)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|interpro:IPR000304(Delta 1-pyrroline-5-carboxylate reductase)|interpro:IPR008927(6-phosphogluconate dehydrogenase, C-terminal-like)|interpro:IPR028939|interpro:IPR029036|interpro:IPR036291|mint:P32322|rcsb pdb:2GER|rcsb pdb:2GR9|rcsb pdb:2GRA|rcsb pdb:2IZZ|rcsb pdb:5UAT|rcsb pdb:5UAU|rcsb pdb:5UAV|rcsb pdb:5UAW|rcsb pdb:5UAX|rcsb pdb:6XOZ|rcsb pdb:6XP0|rcsb pdb:6XP1|rcsb pdb:6XP2|rcsb pdb:6XP3|reactome:R-HSA-8964539	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:+hos1FhDb7QofDBHXEBGlWxv+z09606	rigid:55l5QgjJQpfoBhmumqjzf5hhipU	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8WXF1	uniprotkb:P51114	intact:EBI-1392258|uniprotkb:Q5JTQ3|uniprotkb:Q8NCZ9|uniprotkb:Q8WXE8|uniprotkb:Q9NV36|ensembl:ENSP00000343966|ensembl:ENSP00000481916	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	psi-mi:pspc1_human(display_long)|uniprotkb:PSPC1(gene name)|psi-mi:PSPC1(display_short)|uniprotkb:PSP1(gene name synonym)|uniprotkb:Paraspeckle protein 1(gene name synonym)	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511113|imex:IM-28561-1667	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006719907.1|refseq:NP_001035879.1|dip:DIP-39028N|refseq:XP_016876139.1|ensembl:ENSG00000121390(gene)|ensembl:ENST00000338910(transcript)|ensembl:ENST00000619300(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001650"(fibrillar center)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0045087"(innate immune response)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048511"(rhythmic process)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR012975(NOPS)|interpro:IPR034522|interpro:IPR034523|interpro:IPR035979|mint:Q8WXF1|rcsb pdb:3SDE|rcsb pdb:5IFN|rcsb pdb:5WPA	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:voQ5zJMl7FYato9iDkUYfzZ3q/k9606	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rigid:mxTtlz2Fz0aMcPSnm3oPZZYOJJ8	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:P61289	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-355546|uniprotkb:O35563|uniprotkb:P97373|uniprotkb:Q12920|uniprotkb:Q13172|uniprotkb:Q9BQD9|uniprotkb:A8K9A3|ensembl:ENSP00000466794	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:psme3_human(display_long)|uniprotkb:PSME3(gene name)|psi-mi:PSME3(display_short)|uniprotkb:Proteasome activator 28 subunit gamma(gene name synonym)|uniprotkb:Activator of multicatalytic protease subunit 3(gene name synonym)|uniprotkb:11S regulator complex subunit gamma(gene name synonym)|uniprotkb:Ki nuclear autoantigen(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511104|imex:IM-28561-1665	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_005780.2|refseq:NP_789839.1|ensembl:ENSG00000131467(gene)|ensembl:ENST00000590720(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0002039"(p53 binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008537"(proteasome activator complex)|go:"GO:0010950"(positive regulation of endopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR003185(Proteasome activator pa28, REG alpha subunit)|interpro:IPR003186(Proteasome activator pa28, REG beta subunit)|interpro:IPR009077(Proteasome activator pa28, REG alpha/beta subunit)|interpro:IPR036252|interpro:IPR036996|interpro:IPR036997|mint:P61289|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:6EQY2Kj3Juf++m4eBDzPWMgbC2k9606	rigid:TiRK2TTrI20LMNhAgUKhwaygWow	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q06323	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-712149|uniprotkb:H0YNE3|ensembl:ENSP00000206451|ensembl:ENSP00000495095|uniprotkb:Q9UEF4|uniprotkb:Q6IBM2|uniprotkb:A6NJG9	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:psme1_human(display_long)|uniprotkb:Proteasome activator 28 subunit alpha(gene name synonym)|uniprotkb:Activator of multicatalytic protease subunit 1(gene name synonym)|uniprotkb:11S regulator complex subunit alpha(gene name synonym)|uniprotkb:Interferon gamma up-regulated I-5111 protein(gene name synonym)|uniprotkb:PSME1(gene name)|psi-mi:PSME1(display_short)|uniprotkb:IFI5111(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511095|imex:IM-28561-287	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	reactome:R-HSA-5678895|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-5687128|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|ensembl:ENSG00000092010(gene)|ensembl:ENSG00000284916(gene)|ensembl:ENST00000206451(transcript)|ensembl:ENST00000645537(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008537"(proteasome activator complex)|go:"GO:0010950"(positive regulation of endopeptidase activity)|go:"GO:0019884"(antigen processing and presentation of exogenous antigen)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR003185(Proteasome activator pa28, REG alpha subunit)|interpro:IPR003186(Proteasome activator pa28, REG beta subunit)|interpro:IPR009077(Proteasome activator pa28, REG alpha/beta subunit)|interpro:IPR036252|interpro:IPR036996|interpro:IPR036997|mint:Q06323|rcsb pdb:1AVO|rcsb pdb:7DR6|rcsb pdb:7DRW|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|refseq:NP_006254.1|refseq:NP_001268457.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:kyTjI3VP2S7Bvwq4R0pJudnlOC09606	rigid:ranEjV+H6Yh/OnChJU9nPELDE2Q	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:P62195	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-357745|uniprotkb:O35051|uniprotkb:O43208|uniprotkb:P52915|uniprotkb:P47210|uniprotkb:P52916|uniprotkb:A8K763|uniprotkb:A8K3Z3|ensembl:ENSP00000310572	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:prs8_human(display_long)|uniprotkb:PSMC5(gene name)|psi-mi:PSMC5(display_short)|uniprotkb:SUG1(gene name synonym)|uniprotkb:Proteasome 26S subunit ATPase 5(gene name synonym)|uniprotkb:Proteasome subunit p45(gene name synonym)|uniprotkb:p45/SUG(gene name synonym)|uniprotkb:Thyroid hormone receptor-interacting protein 1(gene name synonym)|uniprotkb:26S proteasome AAA-ATPase subunit RPT6(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511086|imex:IM-28561-285	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_001186092.1|refseq:NP_002796.4|reactome:R-HSA-195253|ensembl:ENSG00000087191(gene)|ensembl:ENST00000310144(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031531"(thyrotropin-releasing hormone receptor binding)|go:"GO:0031595"(nuclear proteasome complex)|go:"GO:0031597"(cytosolic proteasome complex)|go:"GO:0036402"(proteasome-activating activity)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0090261"(positive regulation of inclusion body assembly)|go:"GO:0098794"(postsynapse)|go:"GO:0140296"(general transcription initiation factor binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005937(26S proteasome subunit P45)|interpro:IPR027417|interpro:IPR032501|interpro:IPR041569|mint:P62195|rcsb pdb:2KRK|rcsb pdb:3KW6|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|rcsb pdb:5VHM|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|dip:DIP-36645N	-	-	crc64:29C6410C4A85A7F7	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:zgUTOX/O4m86U/Nf+pnT7u0m0gY9606	rigid:/iZwZvZnLqfHw2T4wbS9MK5n31A	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:P17980	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-359720|uniprotkb:Q3B757|ensembl:ENSP00000298852|ensembl:ENSP00000481029|uniprotkb:Q3B865|uniprotkb:Q53HU5|uniprotkb:Q6GPG8|uniprotkb:Q6IBS1|uniprotkb:Q96HD3|uniprotkb:B2R8V1	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:prs6a_human(display_long)|uniprotkb:PSMC3(gene name)|psi-mi:PSMC3(display_short)|uniprotkb:TBP1(gene name synonym)|uniprotkb:Proteasome 26S subunit ATPase 3(gene name synonym)|uniprotkb:Tat-binding protein 1(gene name synonym)|uniprotkb:Proteasome subunit P50(gene name synonym)|uniprotkb:26S proteasome AAA-ATPase subunit RPT5(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511077|imex:IM-28561-103	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_002795.2|ensembl:ENSG00000165916(gene)|ensembl:ENST00000298852(transcript)|ensembl:ENST00000619920(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0000932"(P-body)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030163"(protein catabolic process)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0043921"(modulation by host of viral transcription)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005937(26S proteasome subunit P45)|interpro:IPR027417|interpro:IPR032501|interpro:IPR035254|interpro:IPR041569|mint:P17980|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|rcsb pdb:5VHM|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|go:"GO:0036402"(proteasome-activating activity)|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-1236978|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|dip:DIP-27555N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:CejeauChmqeXNwBYF2cPz7mgMuw9606	rigid:JS6LOUiIcWJh38TYBDQXC5zI0Es	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q13829	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-2505861|uniprotkb:B7Z6M4|uniprotkb:Q5TZQ1|ensembl:ENSP00000226225	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:bacd2_human(display_long)|uniprotkb:BACURD2(gene name synonym)|uniprotkb:BTB/POZ domain-containing protein TNFAIP1(gene name synonym)|uniprotkb:Protein B12(gene name synonym)|uniprotkb:TNFAIP1(gene name)|psi-mi:TNFAIP1(display_short)|uniprotkb:EDP1(gene name synonym)|uniprotkb:Tumor necrosis factor, alpha-induced protein 1, endothelial(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511369|imex:IM-28561-543	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_066960.1|ensembl:ENSG00000109079(gene)|ensembl:ENST00000226225(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006955"(immune response)|go:"GO:0016477"(cell migration)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030332"(cyclin binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0051260"(protein homooligomerization)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR003131(Potassium channel, voltage dependent, Kv,  tetramerisation)|interpro:IPR011333(BTB/POZ fold)|mint:Q13829|reactome:R-HSA-9696264|reactome:R-HSA-9696270	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:8vM9HnNmkirDbJRETV/TeE8pONY9606	rigid:jp12zo/z91DIIXrxCLUyuxgbb0g	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q15631	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-1044160|uniprotkb:Q5U0K7|ensembl:ENSP00000374332|uniprotkb:B7Z3X8	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:tsn_human(display_long)|uniprotkb:TSN(gene name)|psi-mi:TSN(display_short)|uniprotkb:Component 3 of promoter of RISC(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511424|imex:IM-28561-965	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006310"(DNA recombination)|go:"GO:0016070"(RNA metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR002848(Translin)|interpro:IPR033956|interpro:IPR036081|mint:Q15631|rcsb pdb:1J1J|rcsb pdb:3PJA|interpro:IPR016068(Translin, N-terminal)|rcsb pdb:3QB5|rcsb pdb:4WYV|reactome:R-HSA-426486|interpro:IPR016069(Translin, C-terminal)|ensembl:ENSG00000211460(gene)|ensembl:ENST00000389682(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|refseq:NP_004613.1|refseq:NP_001248330.1|dip:DIP-42216N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:Gv/cF7n6u7XUAQMK/YVsJ0yG93I9606	rigid:4h688+eiAfedli8BLN4dPFJnTUM	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q9H2D6	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-715619|uniprotkb:B1AHD4|uniprotkb:B1AHD7|uniprotkb:O94797|uniprotkb:Q2PZW8|uniprotkb:Q2Q3Z9|uniprotkb:Q2Q400|uniprotkb:Q5R3M6|uniprotkb:Q96DW1|uniprotkb:Q9BT77|uniprotkb:Q9BTL7|uniprotkb:Q9BY98|uniprotkb:Q9Y3L4|ensembl:ENSP00000496394|intact:EBI-2560917|uniprotkb:F2Z2W0|uniprotkb:F8W6V6	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:tara_human(display_long)|uniprotkb:Protein Tara(gene name synonym)|uniprotkb:Trio-associated repeat on actin(gene name synonym)|uniprotkb:TRIOBP(gene name)|psi-mi:TRIOBP(display_short)|uniprotkb:KIAA1662(gene name synonym)|uniprotkb:TARA(gene name synonym)|uniprotkb:HRIHFB2122(orf name)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511415|imex:IM-28561-1453	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_001034230.1|refseq:NP_008963.3|refseq:NP_619538.2|ensembl:ENSG00000100106(gene)|ensembl:ENST00000644935(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0007049"(cell cycle)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030047"(actin modification)|go:"GO:0030496"(midbody)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0045159"(myosin II binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0051016"(barbed-end actin filament capping)|go:"GO:0051301"(cell division)|go:"GO:0060088"(auditory receptor cell stereocilium organization)|go:"GO:0120044"(stereocilium base)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039597|mint:Q9H2D6|reactome:R-HSA-9662360|reactome:R-HSA-9662361|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:2evioSQxAnH1x5VPGsZyK+fJTY09606	rigid:VDtCB0A8OFArxYReht07DlkXOuQ	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:O75382	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-2129889|uniprotkb:Q4V9L4|uniprotkb:Q9C038|uniprotkb:Q9C039|uniprotkb:B7Z5E6|uniprotkb:F5H2Q8|ensembl:ENSP00000340797|ensembl:ENSP00000352508|ensembl:ENSP00000433102	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:trim3_human(display_long)|uniprotkb:TRIM3(gene name)|psi-mi:TRIM3(display_short)|uniprotkb:BERP(gene name synonym)|uniprotkb:RNF22(gene name synonym)|uniprotkb:RNF97(gene name synonym)|uniprotkb:RING finger protein 22(gene name synonym)|uniprotkb:Brain-expressed RING finger protein(gene name synonym)|uniprotkb:RING finger protein 97(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511408|imex:IM-28561-111	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:XP_011518146.1|refseq:XP_011518147.1|refseq:NP_006449.2|refseq:NP_150594.2|refseq:XP_016872587.1|refseq:XP_016872588.1|refseq:NP_001234935.1|refseq:NP_001234936.1|ensembl:ENSG00000110171(gene)|ensembl:ENST00000345851(transcript)|ensembl:ENST00000359518(transcript)|ensembl:ENST00000525074(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0007399"(nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015031"(protein transport)|go:"GO:0030425"(dendrite)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001258(NHL repeat)|interpro:IPR001298(Filamin/ABP280 repeat)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003649(B-box, C-terminal)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR013017(NHL repeat, subgroup)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR017907|interpro:IPR027370|mint:O75382|reactome:R-HSA-877300	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:Vz2XqDSJXAWxxubxtghV91m9K009606	rigid:D9W+U8UPoHtZNdGDwO6564XZcbI	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q12931	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-1055869|uniprotkb:O43642|uniprotkb:O75235|uniprotkb:Q9UHL5|uniprotkb:B4DR68|uniprotkb:F5H897|uniprotkb:D3DUC8|ensembl:ENSP00000246957	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:trap1_human(display_long)|uniprotkb:TRAP1(gene name)|psi-mi:TRAP1(display_short)|uniprotkb:HSP75(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein(gene name synonym)|uniprotkb:TNFR-associated protein 1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511401|imex:IM-28561-109	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_057376.2|refseq:NP_001258978.1|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006457"(protein folding)|go:"GO:0009386"(translational attenuation)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:1901856"(negative regulation of cellular respiration)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|go:"GO:1903751"(negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:Q12931|rcsb pdb:4Z1F|rcsb pdb:4Z1G|rcsb pdb:4Z1H|rcsb pdb:4Z1I|rcsb pdb:5F3K|rcsb pdb:5F5R|rcsb pdb:5HPH|rcsb pdb:5Y3N|rcsb pdb:5Y3O|rcsb pdb:6XG6|rcsb pdb:7C04|rcsb pdb:7C05|rcsb pdb:7C7B|rcsb pdb:7C7C|reactome:R-HSA-611105|ensembl:ENSG00000126602(gene)|ensembl:ENST00000246957(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|dip:DIP-6250N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:O/i+7vgZQcDQF3xJTeqNLbWiQ8U9606	rigid:5jqJSlUKRxRfo1fyEXsSyznARuo	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q12933	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-355744|uniprotkb:Q96NT2|uniprotkb:A8K107|uniprotkb:B4DPJ7|uniprotkb:Q7Z337|intact:EBI-1046651|ensembl:ENSP00000247668	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:traf2_human(display_long)|uniprotkb:TRAF2(gene name)|psi-mi:TRAF2(display_short)|uniprotkb:TRAP3(gene name synonym)|uniprotkb:Tumor necrosis factor type 2 receptor-associated protein 3(gene name synonym)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511392|imex:IM-28561-1181	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_066961.2|refseq:XP_011517279.1|refseq:XP_011517280.1|refseq:XP_011517276.1|refseq:XP_011517277.1|refseq:XP_011517278.1|ensembl:ENSG00000127191(gene)|ensembl:ENST00000247668(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005174"(CD40 receptor binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034622"|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027133|interpro:IPR032070|interpro:IPR037305|interpro:IPR043211|mint:Q12933|rcsb pdb:1CA4|rcsb pdb:1CA9|rcsb pdb:1CZY|rcsb pdb:1CZZ|rcsb pdb:1D00|rcsb pdb:1D01|rcsb pdb:1D0A|rcsb pdb:1D0J|rcsb pdb:1F3V|rcsb pdb:1QSC|rcsb pdb:3KNV|rcsb pdb:3M06|rcsb pdb:3M0A|rcsb pdb:3M0D|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5668541|reactome:R-HSA-5675482|reactome:R-HSA-5676594|reactome:R-HSA-5689880|reactome:R-HSA-69416|reactome:R-HSA-75893|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-9693928|refseq:XP_016870584.1|dip:DIP-6223N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:JhaoM5kRLh3zwhXr+BsCCRNOYa09606	rigid:KR3Z6XLzrww/nXcb/YTq8m+HbcQ	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:P04637	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-366083|uniprotkb:Q15086|uniprotkb:Q15087|uniprotkb:Q15088|uniprotkb:Q16535|uniprotkb:Q16807|uniprotkb:Q16808|uniprotkb:Q16809|uniprotkb:Q16810|uniprotkb:Q16811|uniprotkb:Q16848|uniprotkb:Q86UG1|uniprotkb:Q8J016|uniprotkb:Q99659|uniprotkb:Q9BTM4|uniprotkb:Q9HAQ8|uniprotkb:Q9NP68|uniprotkb:Q9NPJ2|uniprotkb:Q9NZD0|uniprotkb:Q9UBI2|uniprotkb:Q9UQ61|ensembl:ENSP00000269305|ensembl:ENSP00000391478|intact:EBI-28980681|uniprotkb:Q2XN98|uniprotkb:Q3LRW1|uniprotkb:Q3LRW2|uniprotkb:Q3LRW3|uniprotkb:Q3LRW4|uniprotkb:Q3LRW5	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:p53_human(display_long)|uniprotkb:TP53(gene name)|psi-mi:TP53(display_short)|uniprotkb:P53(gene name synonym)|uniprotkb:Tumor suppressor p53(gene name synonym)|uniprotkb:Phosphoprotein p53(gene name synonym)|uniprotkb:Antigen NY-CO-13(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511385|imex:IM-28561-1451	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_001263624.1|refseq:NP_001263625.1|ensembl:ENSG00000141510(gene)|ensembl:ENST00000269305(transcript)|ensembl:ENST00000445888(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001756"(somitogenesis)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002309"(T cell proliferation involved in immune response)|go:"GO:0002360"(T cell lineage commitment)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0031497"(chromatin assembly)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034103"(regulation of tissue remodeling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035033"(histone deacetylase regulator activity)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035690"|go:"GO:0035794"(positive regulation of mitochondrial membrane permeability)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0036310"(ATP-dependent DNA/DNA annealing activity)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0002931"(response to ischemia)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0006983"(ER overload response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007369"(gastrulation)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043504"(mitochondrial DNA repair)|go:"GO:0043516"(regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0043621"(protein self-association)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048512"(circadian behavior)|go:"GO:0048539"(bone marrow development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051097"(negative regulation of helicase activity)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062100"(positive regulation of programmed necrotic cell death)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071494"(cellular response to UV-C)|go:"GO:0072331"(signal transduction by p53 class mediator)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0072717"(cellular response to actinomycin D)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090343"(positive regulation of cell aging)|go:"GO:0090399"(replicative senescence)|go:"GO:0090403"(oxidative stress-induced premature senescence)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0097252"(oligodendrocyte apoptotic process)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0140296"(general transcription initiation factor binding)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|go:"GO:1901525"(negative regulation of mitophagy)|go:"GO:1902108"(regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1902253"(regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904024"(negative regulation of glucose catabolic process to lactate via pyruvate)|go:"GO:1905856"(negative regulation of pentose-phosphate shunt)|go:"GO:1990144"(intrinsic apoptotic signaling pathway in response to hypoxia)|go:"GO:1990248"(regulation of transcription from RNA polymerase II promoter in response to DNA damage)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000269"(regulation of fibroblast apoptotic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000772"(regulation of cellular senescence)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|go:"GO:0007569"(cell aging)|go:"GO:0008104"(protein localization)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009299"(mRNA transcription)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009651"(response to salt stress)|go:"GO:0010165"(response to X-ray)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0016032"(viral process)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031065"(positive regulation of histone deacetylation)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013872("p53 transactivation domain (TAD)")|interpro:IPR036674|interpro:IPR040926|rcsb pdb:2ATA|rcsb pdb:2B3G|rcsb pdb:2BIM|rcsb pdb:2BIN|rcsb pdb:2BIO|rcsb pdb:2BIP|rcsb pdb:2AHI|rcsb pdb:2BIQ|rcsb pdb:2F1X|rcsb pdb:2FEJ|rcsb pdb:2FOJ|rcsb pdb:2FOO|rcsb pdb:2GS0|rcsb pdb:2H1L|rcsb pdb:2H2D|rcsb pdb:2H2F|rcsb pdb:2H4F|rcsb pdb:2H4H|rcsb pdb:2H4J|rcsb pdb:2H59|rcsb pdb:2J0Z|rcsb pdb:2J10|rcsb pdb:2J11|rcsb pdb:2J1W|rcsb pdb:2J1X|rcsb pdb:2J1Y|rcsb pdb:2J1Z|rcsb pdb:2J20|rcsb pdb:2J21|rcsb pdb:2K8F|rcsb pdb:2L14|rcsb pdb:2LY4|rcsb pdb:2MEJ|rcsb pdb:2MWO|rcsb pdb:2MWP|rcsb pdb:2MWY|rcsb pdb:2MZD|rcsb pdb:2OCJ|rcsb pdb:2PCX|rcsb pdb:1A1U|rcsb pdb:1AIE|rcsb pdb:1C26|rcsb pdb:1DT7|rcsb pdb:1GZH|rcsb pdb:1H26|rcsb pdb:1HS5|rcsb pdb:1JSP|rcsb pdb:1KZY|rcsb pdb:1MA3|rcsb pdb:1OLG|rcsb pdb:1OLH|rcsb pdb:1PES|rcsb pdb:1PET|mint:P04637|rcsb pdb:1SAE|rcsb pdb:1SAF|rcsb pdb:1SAK|rcsb pdb:1SAL|rcsb pdb:1TSR|rcsb pdb:1TUP|rcsb pdb:1UOL|rcsb pdb:1XQH|rcsb pdb:1YC5|rcsb pdb:1YCQ|rcsb pdb:1YCR|rcsb pdb:1YCS|rcsb pdb:2AC0|rcsb pdb:2ADY|refseq:NP_000537.3|refseq:NP_001119584.1|refseq:NP_001119585.1|refseq:NP_001119586.1|refseq:NP_001119587.1|refseq:NP_001119588.1|refseq:NP_001119589.1|rcsb pdb:2RUK|rcsb pdb:2VUK|rcsb pdb:3Q06|rcsb pdb:2WGX|rcsb pdb:2X0U|rcsb pdb:2X0V|rcsb pdb:2X0W|rcsb pdb:2XWR|rcsb pdb:2YBG|rcsb pdb:2YDR|rcsb pdb:2Z5S|rcsb pdb:2Z5T|rcsb pdb:3SAK|rcsb pdb:3D05|rcsb pdb:3D06|rcsb pdb:3D07|rcsb pdb:3D08|rcsb pdb:3D09|rcsb pdb:3D0A|rcsb pdb:3DAB|rcsb pdb:3DAC|rcsb pdb:3IGK|rcsb pdb:3IGL|rcsb pdb:3KMD|rcsb pdb:3TG5|rcsb pdb:3KZ8|rcsb pdb:3LW1|rcsb pdb:3OQ5|rcsb pdb:3PDH|rcsb pdb:3Q01|rcsb pdb:3Q05|rcsb pdb:3TS8|rcsb pdb:3ZME|rcsb pdb:4AGM|rcsb pdb:4AGN|rcsb pdb:4AGO|rcsb pdb:4AGP|rcsb pdb:4AGQ|rcsb pdb:4BUZ|rcsb pdb:4BV2|rcsb pdb:4HFZ|rcsb pdb:4HJE|rcsb pdb:4IBQ|rcsb pdb:4IBS|rcsb pdb:4IBT|rcsb pdb:4IBU|rcsb pdb:4IBV|rcsb pdb:4IBW|rcsb pdb:4IBY|rcsb pdb:4IBZ|rcsb pdb:4IJT|rcsb pdb:4KVP|rcsb pdb:4LO9|rcsb pdb:4LOE|rcsb pdb:4LOF|rcsb pdb:4MZI|rcsb pdb:4MZR|rcsb pdb:4QO1|rcsb pdb:4RP6|rcsb pdb:4RP7|rcsb pdb:4X34|rcsb pdb:4XR8|rcsb pdb:4ZZJ|rcsb pdb:5A7B|rcsb pdb:5AB9|rcsb pdb:5ABA|rcsb pdb:4AGL|rcsb pdb:5AOI|rcsb pdb:5AOJ|rcsb pdb:5AOK|rcsb pdb:5AOL|rcsb pdb:5AOM|rcsb pdb:6XRE|rcsb pdb:7BWN|rcsb pdb:7DHY|rcsb pdb:7DHZ|rcsb pdb:7EL4|reactome:R-HSA-111448|reactome:R-HSA-139915|reactome:R-HSA-1912408|reactome:R-HSA-2559580|reactome:R-HSA-2559584|reactome:R-HSA-2559585|reactome:R-HSA-2559586|reactome:R-HSA-3232118|reactome:R-HSA-349425|reactome:R-HSA-390471|reactome:R-HSA-5620971|reactome:R-HSA-5628897|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-5693565|reactome:R-HSA-6785807|reactome:R-HSA-6796648|reactome:R-HSA-6803204|reactome:R-HSA-6803205|reactome:R-HSA-6803207|reactome:R-HSA-6803211|reactome:R-HSA-6804114|reactome:R-HSA-6804115|reactome:R-HSA-6804116|reactome:R-HSA-6804754|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804758|reactome:R-HSA-6804759|reactome:R-HSA-6804760|reactome:R-HSA-6811555|reactome:R-HSA-69473|reactome:R-HSA-69481|reactome:R-HSA-69541|reactome:R-HSA-69895|reactome:R-HSA-8852276|reactome:R-HSA-8853884|reactome:R-HSA-8941855|reactome:R-HSA-8943724|reactome:R-HSA-983231|rcsb pdb:5ECG|rcsb pdb:5G4M|rcsb pdb:5G4N|rcsb pdb:5BUA|rcsb pdb:5G4O|rcsb pdb:5HOU|rcsb pdb:5HP0|rcsb pdb:5HPD|rcsb pdb:5LAP|rcsb pdb:5LGY|rcsb pdb:5MCT|rcsb pdb:5MCU|rcsb pdb:5MCV|rcsb pdb:5MCW|rcsb pdb:5MF7|rcsb pdb:5MG7|rcsb pdb:5MHC|rcsb pdb:5MOC|rcsb pdb:5O1A|rcsb pdb:5O1B|rcsb pdb:5O1C|rcsb pdb:5O1D|rcsb pdb:5O1E|rcsb pdb:5O1F|rcsb pdb:5O1G|rcsb pdb:5O1H|rcsb pdb:5O1I|rcsb pdb:5OL0|rcsb pdb:5UN8|rcsb pdb:5XZC|rcsb pdb:6FF9|rcsb pdb:6FJ5|rcsb pdb:6GGA|rcsb pdb:6GGB|rcsb pdb:6GGC|rcsb pdb:6GGD|rcsb pdb:6GGE|rcsb pdb:6GGF|rcsb pdb:6LHD|rcsb pdb:6R5L|rcsb pdb:6RJZ|rcsb pdb:6RK8|rcsb pdb:6RKI|rcsb pdb:6RKK|rcsb pdb:6RKM|rcsb pdb:6RL3|rcsb pdb:6RL4|rcsb pdb:6RL6|rcsb pdb:6RM5|rcsb pdb:6RM7|rcsb pdb:6RWH|rcsb pdb:6RWI|rcsb pdb:6RWS|rcsb pdb:6RWU|rcsb pdb:6RX2|rcsb pdb:6RZ3|rcsb pdb:6S39|rcsb pdb:6S40|rcsb pdb:6S9Q|rcsb pdb:6SHZ|rcsb pdb:6SI0|rcsb pdb:6SI1|rcsb pdb:6SI2|rcsb pdb:6SI3|rcsb pdb:6SI4|rcsb pdb:6SIN|rcsb pdb:6SIO|rcsb pdb:6SIP|rcsb pdb:6SIQ|rcsb pdb:6SL6|rcsb pdb:6SLV|rcsb pdb:6T58|rcsb pdb:6V4F|rcsb pdb:6V4H|rcsb pdb:6VQO|rcsb pdb:6VR1|rcsb pdb:6VR5|rcsb pdb:6VRM|rcsb pdb:6VRN|rcsb pdb:6W51|rcsb pdb:6S3C|ensembl:ENSP00000269305|ensembl:ENST00000420246|ensembl:ENSP00000391127|ensembl:ENSP00000391478|ensembl:ENST00000455263|ensembl:ENSP00000398846|ensembl:ENST00000504290|ensembl:ENSP00000484409|ensembl:ENST00000504937|ensembl:ENSP00000481179|ensembl:ENST00000510385|ensembl:ENSP00000478499|ensembl:ENST00000610292|ensembl:ENSP00000478219|ensembl:ENST00000610538|ensembl:ENSP00000480868|ensembl:ENST00000619485|ensembl:ENSP00000482537|ensembl:ENST00000620739|ensembl:ENSP00000481638|ensembl:ENST00000622645|ensembl:ENSP00000482222|refseq:NP_001119590.1|refseq:NP_001263626.1|refseq:NP_001263627.1|refseq:NP_001263628.1|refseq:NP_001263689.1|refseq:NP_001263690.1|dip:DIP-368N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:fGN3kSCGIpi/D6d/X5kaB0Xu8/k9606	rigid:RHYebFRLCPJTaz0kO6vRY8/5PWE	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q15025	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-357849|uniprotkb:A4F1W8|uniprotkb:O76008|uniprotkb:Q96EL9|uniprotkb:Q99833|uniprotkb:Q9H1J3|uniprotkb:B7Z699|uniprotkb:Q6N077|ensembl:ENSP00000317891|ensembl:ENSP00000428187|ensembl:ENSP00000430760|uniprotkb:A4F1W9|uniprotkb:A4F1X2|uniprotkb:A4F1X4|uniprotkb:A4F1X5|uniprotkb:A4F1X6|uniprotkb:A4F1X7|uniprotkb:A4F1X9|uniprotkb:E7EPY1|uniprotkb:E7ET96|uniprotkb:Q05KP3|uniprotkb:Q05KP4	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:tnip1_human(display_long)|uniprotkb:TNIP1(gene name)|psi-mi:TNIP1(display_short)|uniprotkb:KIAA0113(gene name synonym)|uniprotkb:NAF1(gene name synonym)|uniprotkb:Nef-associated factor 1(gene name synonym)|uniprotkb:HIV-1 Nef-interacting protein(gene name synonym)|uniprotkb:Virion-associated nuclear shuttling protein(gene name synonym)|uniprotkb:Nip40-1(gene name synonym)|uniprotkb:A20-binding inhibitor of NF-kappa-B activation 1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511378|imex:IM-28561-1177	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_006049.3|refseq:NP_001239319.1|refseq:NP_001239320.1|refseq:NP_001239321.1|refseq:NP_001239322.1|refseq:NP_001245383.1|dip:DIP-27577N|refseq:NP_001239315.1|ensembl:ENSG00000145901(gene)|ensembl:ENST00000315050(transcript)|ensembl:ENST00000521591(transcript)|ensembl:ENST00000522226(transcript)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0009101"(glycoprotein biosynthetic process)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0085032"(modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade)|go:"GO:1903003"(positive regulation of protein deubiquitination)|interpro:IPR033372|mint:Q15025|reactome:R-HSA-5689896|go:"GO:0051019"(mitogen-activated protein kinase binding)|refseq:NP_001239314.1|refseq:NP_001245384.1|refseq:NP_001245385.1|refseq:XP_006714814.1|refseq:XP_006714815.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:16Vjb5CuGTAbW2M22qbCxgXtV1o9606	rigid:ofwZkfMOKb+8yqcaaxkhTSGzyxE	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:P42166	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-395393|uniprotkb:P08918|uniprotkb:P08919|uniprotkb:Q14860|uniprotkb:Q16295|ensembl:ENSP00000266732	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:lap2a_human(display_long)|uniprotkb:TMPO(gene name)|psi-mi:TMPO(display_short)|uniprotkb:LAP2(gene name synonym)|uniprotkb:Thymopoietin isoform alpha(gene name synonym)|uniprotkb:Thymopoietin-related peptide isoform alpha(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511362|imex:IM-28561-305	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_003267.1|ensembl:ENSG00000120802(gene)|ensembl:ENST00000266732(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0005521"(lamin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0045296"(cadherin binding)|interpro:IPR003887(Lamino-associated polypeptide 2/emerin)|interpro:IPR011015(LEM-like fold)|interpro:IPR013146(Thymopoietin LEM)|interpro:IPR021623|mint:P42166|rcsb pdb:1GJJ|rcsb pdb:1H9E|rcsb pdb:1H9F	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:/kq+6sQN9B8jf+Ee4uPj7gtWe509606	rigid:Y2q+wFoQWZ+Kyk+SC8jrtbLcYxU	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q8NHU6	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-624505|uniprotkb:A6NCI6|uniprotkb:Q5VV27|uniprotkb:Q96JT1|uniprotkb:Q9UFF0|uniprotkb:Q9Y2M3|uniprotkb:B4DG99|uniprotkb:B4DXF7|uniprotkb:E7EQD4|uniprotkb:B2RBX3|ensembl:ENSP00000347444	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:tdrd7_human(display_long)|uniprotkb:PCTAIRE2-binding protein(gene name synonym)|uniprotkb:PCTAIRE2BP(gene name synonym)|uniprotkb:TDRD7(gene name)|psi-mi:TDRD7(display_short)|uniprotkb:Tudor repeat associator with PCTAIRE-2(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511355|imex:IM-28561-539	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_001289813.1|refseq:NP_055105.2|rcsb pdb:3RCO|ensembl:ENSG00000196116(gene)|ensembl:ENST00000355295(transcript)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0003729"(mRNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0033391"(chromatoid body)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0070306"(lens fiber cell differentiation)|interpro:IPR002999(Tudor)|interpro:IPR025605|interpro:IPR035437|interpro:IPR037978|interpro:IPR041966|mint:Q8NHU6	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:VMaw7t5OgA2O0RRDagDVSc+vUUU9606	rigid:8y/D4nng+L8I1jKgq4rdb1B0XQw	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:O95359	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-720382|uniprotkb:Q4VXL6|uniprotkb:Q4VXL7|uniprotkb:Q5U5T7|uniprotkb:Q86WG6|uniprotkb:Q86WG7|uniprotkb:Q4VXL0|uniprotkb:Q4VXL3|uniprotkb:Q8TCK9|uniprotkb:Q9BVQ1|uniprotkb:Q9NZ41|uniprotkb:Q9NZR5|intact:EBI-2558151|intact:EBI-28968297|ensembl:ENSP00000334280|ensembl:ENSP00000358001	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:tacc2_human(display_long)|uniprotkb:Anti-Zuai-1(gene name synonym)|uniprotkb:TACC2(gene name)|psi-mi:TACC2(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511346|imex:IM-28561-537	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_001278807.1|refseq:NP_996744.3|refseq:NP_008928.1|refseq:NP_996742.1|refseq:NP_996743.1|ensembl:ENST00000260733|ensembl:ENSP00000260733|ensembl:ENSP00000334280|ensembl:ENST00000358010|ensembl:ENSP00000350701|ensembl:ENST00000360561|ensembl:ENSP00000353763|ensembl:ENST00000369000|ensembl:ENSP00000357996|ensembl:ENSP00000358001|ensembl:ENST00000513429|ensembl:ENSP00000425062|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0021987"(cerebral cortex development)|interpro:IPR007707(Transforming acidic coiled-coil-containing)|interpro:IPR039915|mint:O95359|go:"GO:0008283"(cell population proliferation)|ensembl:ENSG00000138162(gene)|ensembl:ENST00000334433(transcript)|ensembl:ENST00000369005(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007052"(mitotic spindle organization)	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:F497RHDDNDqTPKybxJ/DiuhfjAc9606	rigid:HBIcLPRL/Hfvf/tBI6SxKnh9ZdU	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q9UNE7	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-357085|uniprotkb:O60526|uniprotkb:Q969U2|uniprotkb:Q9HBT1|uniprotkb:A2IDB9|ensembl:ENSP00000219548	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:chip_human(display_long)|uniprotkb:CHIP(gene name synonym)|uniprotkb:STUB1(gene name)|psi-mi:STUB1(display_short)|uniprotkb:PP1131(orf name)|uniprotkb:Carboxy terminus of Hsp70-interacting protein(gene name synonym)|uniprotkb:STIP1 homology and U box-containing protein 1(gene name synonym)|uniprotkb:CLL-associated antigen KW-8(gene name synonym)|uniprotkb:Antigen NY-CO-7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CHIP(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511339|imex:IM-28561-1673	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	dip:DIP-29752N|refseq:NP_005852.2|refseq:NP_001280126.1|ensembl:ENSG00000103266(gene)|ensembl:ENST00000219548(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031943"(regulation of glucocorticoid metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046332"(SMAD binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051604"(protein maturation)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090035"(positive regulation of chaperone-mediated protein complex assembly)|go:"GO:0101031"(chaperone complex)|interpro:IPR003613(U box)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019734|interpro:IPR041312|mint:Q9UNE7|rcsb pdb:4KBQ|rcsb pdb:6EFK|rcsb pdb:6NSV|reactome:R-HSA-2173788|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-8939902|reactome:R-HSA-8948751|reactome:R-HSA-983168	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:h4QyIM0TptgkQppPUgiKn68XjP49606	rigid:rwM8anJUauZhveoXC6gOD1EBLVY	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:O43805	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-2515299|ensembl:ENSP00000313752|uniprotkb:Q9BVW8|uniprotkb:Q6FG70|uniprotkb:Q5VSG0	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:ssna1_human(display_long)|uniprotkb:SSNA1(gene name)|psi-mi:SSNA1(display_short)|uniprotkb:NA14(gene name synonym)|uniprotkb:Nuclear autoantigen of 14 kDa(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511332|imex:IM-28561-1449	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	ensembl:ENSG00000176101(gene)|ensembl:ENST00000322310(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042073"(intraciliary transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0060830"(ciliary receptor clustering involved in smoothened signaling pathway)|interpro:IPR033362|mint:O43805|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-8854518|refseq:NP_003722.2	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:W48R8M8go89X1aS1L1AHejuOO+g9606	rigid:Zyr+1MM0twOaA6TQXb+KUuDy/Pw	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:O43597	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-742487|uniprotkb:Q5T6Z7|ensembl:ENSP00000366306|ensembl:ENSP00000366308|uniprotkb:B2R9J9	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:spy2_human(display_long)|uniprotkb:SPRY2(gene name)|psi-mi:SPRY2(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511325|imex:IM-28561-1447	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_005833.1|rcsb pdb:5HL0|reactome:R-HSA-1295596|reactome:R-HSA-182971|rcsb pdb:5HKZ|ensembl:ENST00000377102(transcript)|ensembl:ENST00000377104(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|ensembl:ENSG00000136158(gene)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030291"(protein serine/threonine kinase inhibitor activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031345"(negative regulation of cell projection organization)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045165"(cell fate commitment)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048513"(animal organ development)|go:"GO:0051387"(negative regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060437"(lung growth)|go:"GO:0060449"(bud elongation involved in lung branching)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:1900747"(negative regulation of vascular endothelial growth factor signaling pathway)|go:"GO:1902747"(negative regulation of lens fiber cell differentiation)|go:"GO:1990752"(microtubule end)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR007875(Sprouty)|interpro:IPR030780|mint:O43597|rcsb pdb:3BUM|rcsb pdb:3OB1|rcsb pdb:5HKY|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|refseq:NP_001305465.1|refseq:NP_001305466.1|refseq:NP_001305467.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:u1omauzisc6MdZlogMotUmtauSI9606	rigid:re+vQzPHH43ZPlvhmkt1K0QE70w	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:O43609	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-3866665|uniprotkb:Q6PNE0|uniprotkb:D3DNX6|ensembl:ENSP00000343785|ensembl:ENSP00000377871|ensembl:ENSP00000480540|ensembl:ENSP00000481675|ensembl:ENSP00000498292	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:spy1_human(display_long)|uniprotkb:SPRY1(gene name)|psi-mi:SPRY1(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511318|imex:IM-28561-303	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_005832.1|refseq:NP_955359.1|refseq:NP_001244967.1|refseq:NP_001244968.1|refseq:XP_005262743.1|ensembl:ENSG00000164056(gene)|ensembl:ENST00000339241(transcript)|ensembl:ENST00000394339(transcript)|ensembl:ENST00000610581(transcript)|ensembl:ENST00000622283(transcript)|ensembl:ENST00000651917(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0001656"(metanephros development)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001759"(organ induction)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048513"(animal organ development)|go:"GO:0051387"(negative regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0060449"(bud elongation involved in lung branching)|go:"GO:0060940"(epithelial to mesenchymal transition involved in cardiac fibroblast development)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:1902747"(negative regulation of lens fiber cell differentiation)|interpro:IPR007875(Sprouty)|interpro:IPR030783|mint:O43609|reactome:R-HSA-182971|refseq:XP_016863124.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:tbucIEQYibDQbBC1xVIZVDH2nIY9606	rigid:N7GpUnj6nx76iLwiPxzTPiRx2es	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:P35711	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-3505701|uniprotkb:Q86UK8|uniprotkb:Q8J017|uniprotkb:Q8J018|uniprotkb:Q8J019|uniprotkb:Q8J020|uniprotkb:Q8N1D9|uniprotkb:Q8N7E0|uniprotkb:Q8TEA4|uniprotkb:B7Z8V0|uniprotkb:F5H5B0|ensembl:ENSP00000398273	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:sox5_human(display_long)|uniprotkb:SOX5(gene name)|psi-mi:SOX5(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511311|imex:IM-28561-293	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_008871.3|refseq:NP_694534.1|refseq:NP_821078.1|refseq:NP_001248343.1|refseq:NP_001248344.1|ensembl:ENSG00000134532(gene)|ensembl:ENST00000451604(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001502"(cartilage condensation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0045165"(cell fate commitment)|go:"GO:0051216"(cartilage development)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:2000741"(positive regulation of mesenchymal stem cell differentiation)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR036910|mint:P35711|refseq:NP_001317714.1|refseq:XP_016875385.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:YVl5zcnqafFgRvQt8B79kMtbz+g9606	rigid:1I5GfhZZcHlICn0nTh5W+9SL8+c	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:O60504	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-741237|ensembl:ENSP00000240123|uniprotkb:Q5BJE4|uniprotkb:Q6NX54|uniprotkb:Q9UQE4|intact:EBI-1222937|uniprotkb:Q96FY4	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:vinex_human(display_long)|uniprotkb:SCAM1(gene name synonym)|uniprotkb:SH3-containing adapter molecule 1(gene name synonym)|uniprotkb:Sorbin and SH3 domain-containing protein 3(gene name synonym)|uniprotkb:SORBS3(gene name)|psi-mi:SORBS3(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511302|imex:IM-28561-963	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	ensembl:ENSG00000120896(gene)|ensembl:ENST00000240123(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0017166"(vinculin binding)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0051495"(positive regulation of cytoskeleton organization)|go:"GO:0051496"(positive regulation of stress fiber assembly)|interpro:IPR001452(Src homology-3)|interpro:IPR003127(Sorbin-like)|interpro:IPR028510|interpro:IPR035607|interpro:IPR035608|interpro:IPR035609|interpro:IPR036028|mint:O60504|rcsb pdb:2CT3|rcsb pdb:2DLM|rcsb pdb:2NWM|rcsb pdb:2YUP|reactome:R-HSA-445355|refseq:NP_001018003.1|refseq:NP_005766.3|refseq:XP_005273428.1|refseq:XP_016868433.1|refseq:XP_016868434.1|refseq:XP_016868435.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:Mq3VXduU/1gqfUwliO9sBBOb/Vc9606	rigid:o0Wu75NBIJpwMfTI0h8zhCxwUJ4	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q9Y675	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-2129232|uniprotkb:A6NCW2|ensembl:ENSP00000342152|ensembl:ENSP00000463201|ensembl:ENSP00000463396	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:snurf_human(display_long)|uniprotkb:SNURF(gene name)|psi-mi:SNURF(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511295|imex:IM-28561-743	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_005669.2|refseq:NP_073715.1|ensembl:ENSG00000273173(gene)|ensembl:ENST00000338327(transcript)|ensembl:ENST00000577949(transcript)|ensembl:ENST00000580062(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0016607"(nuclear speck)|interpro:IPR009847(SNURFRPN4)|mint:Q9Y675	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:ndmQA8orwXTo94xaCprGe2MOyCU9606	rigid:Cmy0ozU+SU2xVO3KJYEQFII32e8	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:O75093	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-947791|uniprotkb:Q8WWZ2|uniprotkb:Q9UIL7|uniprotkb:Q5T0V1|ensembl:ENSP00000266058	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:slit1_human(display_long)|uniprotkb:Multiple epidermal growth factor-like domains protein 4(gene name synonym)|uniprotkb:SLIT1(gene name)|psi-mi:SLIT1(display_short)|uniprotkb:KIAA0813(gene name synonym)|uniprotkb:MEGF4(gene name synonym)|uniprotkb:SLIL1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511286|imex:IM-28561-1671	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_003052.2|ensembl:ENSG00000187122(gene)|ensembl:ENST00000266058(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0007097"(nuclear migration)|go:"GO:0007411"(axon guidance)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008201"(heparin binding)|go:"GO:0022028"(tangential migration from the subventricular zone to the olfactory bulb)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0033563"(dorsal/ventral axon guidance)|go:"GO:0048495"(Roundabout binding)|go:"GO:0048846"(axon extension involved in axon guidance)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0051964"(negative regulation of synapse assembly)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001791(Laminin G)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR003645(Follistatin-like, N-terminal)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR018097|interpro:IPR032675|mint:O75093|reactome:R-HSA-373752|reactome:R-HSA-376176|reactome:R-HSA-428542|reactome:R-HSA-8985801|reactome:R-HSA-9010553	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:CLzbkIsFRc56n2LK/zvue0dA+4Q9606	rigid:zxLzs61Urq6i7HfS76xIh2DYbRg	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q6P1K1	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-1222191|uniprotkb:Q9BUB3|uniprotkb:Q9NX17|ensembl:ENSP00000415998	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:hrg1_human(display_long)|uniprotkb:SLC48A1(gene name)|psi-mi:SLC48A1(display_short)|uniprotkb:Heme-responsive gene 1 protein homolog(gene name synonym)|uniprotkb:HRG1(gene name synonym)|uniprotkb:Solute carrier family 48 member 1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511277|imex:IM-28561-1175	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_060312.2|refseq:XP_016875106.1|refseq:XP_016875101.1|refseq:XP_016875103.1|ensembl:ENSG00000211584(gene)|ensembl:ENST00000442218(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0015232"(heme transmembrane transporter activity)|go:"GO:0015886"(heme transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020037"(heme binding)|interpro:IPR026218|mint:Q6P1K1|refseq:XP_016875102.1|refseq:XP_016875104.1|refseq:XP_016875105.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:8mfLinVt8eczyC4sM/2ur/r5Pd89606	rigid:0O448YG7cBFk5PVNUV1PfUEmXGs	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q9H0F6	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-3942966|uniprotkb:D3DWL3|uniprotkb:Q8IXF5|uniprotkb:Q8IXF6|uniprotkb:A6NEG3|uniprotkb:Q8TB25|uniprotkb:Q9BUE4|uniprotkb:Q8N2E7|uniprotkb:C0L3L2|ensembl:ENSP00000381698	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:shrpn_human(display_long)|uniprotkb:SHARPIN(gene name)|psi-mi:SHARPIN(display_short)|uniprotkb:SIPL1(gene name synonym)|uniprotkb:Shank-associated RH domain-interacting protein(gene name synonym)|uniprotkb:Shank-interacting protein-like 1(gene name synonym)|uniprotkb:PSEC0216(orf name)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511270|imex:IM-28561-107	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	ensembl:ENSG00000179526(gene)|ensembl:ENST00000398712(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005829"(cytosol)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007420"(brain development)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030262"(apoptotic nuclear changes)|go:"GO:0030425"(dendrite)|go:"GO:0031424"(keratinization)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0071797"(LUBAC complex)|go:"GO:0097039"(protein linear polyubiquitination)|go:"GO:2000348"(regulation of CD40 signaling pathway)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR026261|reactome:R-HSA-6794361|interpro:IPR029071|interpro:IPR031912|interpro:IPR036443|mint:Q9H0F6|rcsb pdb:4EMO|rcsb pdb:5X0W|reactome:R-HSA-5357905|reactome:R-HSA-5357956|refseq:NP_112236.3|refseq:XP_016869377.1|dip:DIP-57842N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:+RGl3JO1zsGCdaInDn20yhNZs0E9606	rigid:kCjI8C66uDVekc/1nUnAtBoXGXg	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q9Y566	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-3442234|uniprotkb:B7WNY6|uniprotkb:Q9NYW9|uniprotkb:A8MXP5|ensembl:ENSP00000293441	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:shan1_human(display_long)|uniprotkb:SHANK1(gene name)|psi-mi:SHANK1(display_short)|uniprotkb:Somatostatin receptor-interacting protein(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511261|imex:IM-28561-731	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:XP_011525316.1|refseq:XP_006723296.1|refseq:NP_057232.2|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007616"(long-term memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008306"(associative learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030160"(synaptic receptor adaptor activity)|ensembl:ENSG00000161681(gene)|go:"GO:0030425"(dendrite)|go:"GO:0030534"(adult behavior)|ensembl:ENST00000293441(transcript)|go:"GO:0031877"(somatostatin receptor binding)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042048"(olfactory behavior)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046959"(habituation)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0050894"(determination of affect)|go:"GO:0060013"(righting reflex)|go:"GO:0060074"(synapse maturation)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071532"(ankyrin repeat binding)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q9Y566|rcsb pdb:6CPI|rcsb pdb:6YWZ|rcsb pdb:6YX0|rcsb pdb:6YX1|rcsb pdb:6YX2|reactome:R-HSA-6794361|ensembl:ENSP00000293441|ensembl:ENST00000359082|ensembl:ENSP00000351984|dip:DIP-40834N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:XhX+mw+sujJRnA6RoKA1QeVywBY9606	rigid:8j9afhpHCOG9sYXqiXCryzrp4i0	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q9NR46	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-749607|uniprotkb:A8MPS4|uniprotkb:Q8WY61|uniprotkb:Q96JH9|uniprotkb:A6NC47|ensembl:ENSP00000361640|ensembl:ENSP00000361645	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:shlb2_human(display_long)|uniprotkb:SH3 domain-containing GRB2-like protein B2(gene name synonym)|uniprotkb:SH3GLB2(gene name)|psi-mi:SH3GLB2(display_short)|uniprotkb:KIAA1848(gene name synonym)|uniprotkb:PP578(orf name)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511252|imex:IM-28561-1173	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_064530.1|refseq:NP_001273974.1|refseq:NP_001273975.1|refseq:XP_005252158.1|ensembl:ENSG00000148341(gene)|ensembl:ENST00000372559(transcript)|ensembl:ENST00000372564(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|interpro:IPR001452(Src homology-3)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR035640|interpro:IPR036028|mint:Q9NR46	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:9C0QF9xLb5A6eYQBK2aU/J1aGVo9606	rigid:blCvugz9iRnvPkzLn4E9Cc3x0To	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q99962	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-77938|ensembl:ENSP00000369981|uniprotkb:Q9NQK5|uniprotkb:B2R618	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:sh3g2_human(display_long)|uniprotkb:SH3GL2(gene name)|psi-mi:SH3GL2(display_short)|uniprotkb:CNSA2(gene name synonym)|uniprotkb:SH3D2A(gene name synonym)|uniprotkb:Endophilin-1(gene name synonym)|uniprotkb:SH3 domain-containing GRB2-like protein 2(gene name synonym)|uniprotkb:SH3 domain protein 2A(gene name synonym)|uniprotkb:EEN-B1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511245|imex:IM-28561-1171	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	go:"GO:0097749"(membrane tubulation)|go:"GO:0097753"(membrane bending)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099050"(vesicle scission)|go:"GO:1903527"(positive regulation of membrane tubulation)|go:"GO:1905604"(negative regulation of blood-brain barrier permeability)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:2000369"(regulation of clathrin-dependent endocytosis)|interpro:IPR001452(Src homology-3)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR035824|interpro:IPR036028|mint:Q99962|rcsb pdb:1X03|rcsb pdb:1X04|rcsb pdb:2D4C|rcsb pdb:2DBM|reactome:R-HSA-177504|reactome:R-HSA-182971|reactome:R-HSA-2132295|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-437239|reactome:R-HSA-6807004|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|ensembl:ENSG00000107295(gene)|ensembl:ENST00000380607(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008289"(lipid binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031175"(neuron projection development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0060988"(lipid tube assembly)|go:"GO:0097441"(basal dendrite)|go:"GO:0097484"(dendrite extension)|refseq:NP_003017.1|dip:DIP-30996N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:mAk7M0s5Dd2Qoa/e1rPYvVcV3xs9606	rigid:Qjy1wlUI+x9vv/Txyrc82PAM1fI	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:P23246	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-355453|uniprotkb:P30808|uniprotkb:Q5SZ71|ensembl:ENSP00000349748	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:sfpq_human(display_long)|uniprotkb:SFPQ(gene name)|psi-mi:SFPQ(display_short)|uniprotkb:PSF(gene name synonym)|uniprotkb:Polypyrimidine tract-binding protein-associated-splicing factor(gene name synonym)|uniprotkb:DNA-binding p52/p100 complex, 100 kDa subunit(gene name synonym)|uniprotkb:100 kDa DNA-pairing protein(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511236|imex:IM-28561-105	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_005057.1|ensembl:ENSG00000116560(gene)|ensembl:ENST00000357214(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0016363"(nuclear matrix)|go:"GO:0003723"(RNA binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0042382"(paraspeckles)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0005634"(nucleus)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045876"(positive regulation of sister chromatid cohesion)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0048511"(rhythmic process)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0098963"(dendritic transport of messenger ribonucleoprotein complex)|go:"GO:1902177"(positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:0006355"(regulation of transcription, DNA-templated)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR012975(NOPS)|interpro:IPR034525|interpro:IPR034526|interpro:IPR035979|mint:P23246|rcsb pdb:4WII|rcsb pdb:4WIJ|rcsb pdb:4WIK|rcsb pdb:5WPA|rcsb pdb:6NCQ|rcsb pdb:6OWJ|rcsb pdb:6WMZ|rcsb pdb:7LRQ|rcsb pdb:7LRU|reactome:R-HSA-8849468|reactome:R-HSA-9635465|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|refseq:XP_005271169.1|refseq:XP_005271170.1|refseq:XP_005271172.1|refseq:XP_016857542.1|refseq:XP_016857543.1|dip:DIP-31272N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:B7mSc6tthLbSHo0qz0SMZBSl3HA9606	rigid:a5hiLWKWBAvXg0zY14TZV3crUYw	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q13435	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-749111|uniprotkb:A8K485|uniprotkb:B4DT19|uniprotkb:Q7Z627|uniprotkb:Q969K1|uniprotkb:Q96CM6|uniprotkb:Q9BWD2|intact:EBI-1052093|intact:EBI-2688256|uniprotkb:Q7L4T5|ensembl:ENSP00000318861	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:sf3b2_human(display_long)|uniprotkb:SF3B2(gene name)|psi-mi:SF3B2(display_short)|uniprotkb:SAP145(gene name synonym)|uniprotkb:Pre-mRNA-splicing factor SF3b 145 kDa subunit(gene name synonym)|uniprotkb:Spliceosome-associated protein 145(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511229|imex:IM-28561-729	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_006833.2|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005684"(U2-type spliceosomal complex)|go:"GO:0005686"(U2 snRNP)|go:"GO:0005689"(U12-type spliceosomal complex)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|interpro:IPR003034(DNA-binding SAP)|interpro:IPR006568(PSP, proline-rich)|ensembl:ENSG00000087365(gene)|ensembl:ENST00000322535(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|interpro:IPR007180(Protein of unknown function DUF382)|rcsb pdb:2DO5|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6FF4|rcsb pdb:6FF7|rcsb pdb:6QX9|rcsb pdb:6Y50|rcsb pdb:6Y53|mint:Q13435|rcsb pdb:6Y5Q|rcsb pdb:7ABG|rcsb pdb:7ABH|rcsb pdb:7ABI|rcsb pdb:7DVQ|reactome:R-HSA-72163|reactome:R-HSA-72165	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:Y9uCV2x4J5kqyxeO8iXjojkXocA9606	rigid:2x7UP4T3MB7zxi2RqR19C3r5fnE	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q9UHV2	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-748601|uniprotkb:Q9BUE7|ensembl:ENSP00000350633	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:srtd1_human(display_long)|uniprotkb:Transcriptional regulator interacting with the PHD-bromodomain 1(gene name synonym)|uniprotkb:CDK4-binding protein p34SEI1(gene name synonym)|uniprotkb:SERTAD1(gene name)|psi-mi:SERTAD1(display_short)|uniprotkb:SEI1(gene name synonym)|uniprotkb:TRIPBR1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511220|imex:IM-28561-1169	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_037508.2|ensembl:ENSG00000197019(gene)|ensembl:ENST00000357949(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048096"|interpro:IPR009263(SERTA)|mint:Q9UHV2	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:40dvjniwxY/UQiyoVREicctpWe09606	rigid:/6HCwpkK5+W16q3eMtZ2pGtJjVY	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q96GD3	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-713793|uniprotkb:Q5VT76|uniprotkb:Q6IAJ4|uniprotkb:Q8WU48|uniprotkb:Q9UKM5|uniprotkb:Q9UKM6|ensembl:ENSP00000318094|ensembl:ENSP00000380359|uniprotkb:B4DRQ8	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:scmh1_human(display_long)|uniprotkb:Sex comb on midleg homolog 1(gene name synonym)|uniprotkb:SCMH1(gene name)|psi-mi:SCMH1(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511211|imex:IM-28561-291	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:XP_006710527.1|ensembl:ENSG00000010803(gene)|ensembl:ENST00000326197(transcript)|ensembl:ENST00000397174(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0007283"(spermatogenesis)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010369"(chromocenter)|go:"GO:0016458"(obsolete gene silencing)|go:"GO:0042393"(histone binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR004092(Mbt repeat)|interpro:IPR013761(Sterile alpha motif-type)|go:"GO:0005634"(nucleus)|interpro:IPR021987|interpro:IPR033763|interpro:IPR038348|mint:Q96GD3|rcsb pdb:2P0K|reactome:R-HSA-2559580|reactome:R-HSA-3108214|reactome:R-HSA-3899300|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4655427|reactome:R-HSA-8939243|reactome:R-HSA-8943724|refseq:NP_001026864.1|refseq:NP_001165689.1|refseq:NP_001165690.1|refseq:NP_001165691.1|refseq:NP_001165692.1|refseq:NP_001165693.1|refseq:NP_036368.1|refseq:XP_016856188.1|refseq:XP_016856196.1|refseq:XP_011539335.1|refseq:XP_011539338.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:e39O++wYwPAUlKUeNfRurqnXbz09606	rigid:6sT0KwPUOLUBeiXXoXDrp3S6aZg	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q6SPF0	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-8833536|uniprotkb:Q96IM4|uniprotkb:Q6PIS7|uniprotkb:Q6P0R3	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:samd1_human(display_long)|uniprotkb:SAMD1(gene name)|psi-mi:SAMD1(display_short)|uniprotkb:Atherin(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511204|imex:IM-28561-535	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	mint:Q6SPF0|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|refseq:NP_612361.1|go:"GO:0005737"(cytoplasm)|go:"GO:0042393"(histone binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|rcsb pdb:6LUI|rcsb pdb:6LUJ|rcsb pdb:6LUK|go:"GO:0003682"(chromatin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:Cav/ZfHiZJ1xCBI6jAYrzv+CmZ49606	rigid:ovBz070W3QtMm13QONxyWnt9Jg0	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q14151	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-352869|ensembl:ENSP00000252542|uniprotkb:Q8TB13|uniprotkb:B4DKG3|intact:EBI-2948582	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:safb2_human(display_long)|uniprotkb:SAFB2(gene name)|psi-mi:SAFB2(display_short)|uniprotkb:KIAA0138(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511197|imex:IM-28561-1445	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	ensembl:ENSG00000130254(gene)|ensembl:ENST00000252542(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016604"(nuclear body)|interpro:IPR035979|go:"GO:0042802"(identical protein binding)|interpro:IPR036361|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|mint:Q14151|go:"GO:0050684"(regulation of mRNA processing)|go:"GO:0060008"(Sertoli cell differentiation)|go:"GO:0060765"(regulation of androgen receptor signaling pathway)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003034(DNA-binding SAP)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034782|refseq:NP_055464.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:4/eQxEPzUXIuUuqP2ogEL+zY31g9606	rigid:QWVPKbxzjZjqsZTOZPZJ1jG4vlQ	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q8N2Y8	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-722486|uniprotkb:A2RU62|uniprotkb:O15080|uniprotkb:Q5W134|uniprotkb:Q641Q6|uniprotkb:Q6P1W7|uniprotkb:A7E2A9|intact:EBI-28984356|ensembl:ENSP00000355177|ensembl:ENSP00000393922	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:rusc2_human(display_long)|uniprotkb:Interacting protein of Rab1(gene name synonym)|uniprotkb:RUN and SH3 domain-containing protein 2(gene name synonym)|uniprotkb:RUSC2(gene name)|psi-mi:RUSC2(display_short)|uniprotkb:KIAA0375(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511188|imex:IM-28561-533	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_001129471.1|ensembl:ENSP00000355177|ensembl:ENSP00000393922|refseq:NP_055621.1|ensembl:ENSG00000198853(gene)|ensembl:ENST00000361226(transcript)|ensembl:ENST00000455600(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001452(Src homology-3)|interpro:IPR004012(RUN)|interpro:IPR036028|interpro:IPR037213|mint:Q8N2Y8|rcsb pdb:6IF2	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:gsqwJAaLhTQY9djQ3GBVXlCPuYQ9606	rigid:HocG+h+GCU+urWZbhwqx2hokOe8	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:P49247	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-744831|uniprotkb:Q541P9|uniprotkb:Q96BJ6|ensembl:ENSP00000283646	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:rpia_human(display_long)|uniprotkb:Phosphoriboisomerase(gene name synonym)|uniprotkb:RPIA(gene name)|psi-mi:RPIA(display_short)|uniprotkb:RPI(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511179|imex:IM-28561-531	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_653164.2|ensembl:ENSG00000153574(gene)|ensembl:ENST00000283646(transcript)|go:"GO:0004751"(ribose-5-phosphate isomerase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006014"(D-ribose metabolic process)|go:"GO:0006098"(pentose-phosphate shunt)|go:"GO:0009052"(pentose-phosphate shunt, non-oxidative branch)|go:"GO:0019693"(ribose phosphate metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048029"(monosaccharide binding)|interpro:IPR004788(Ribose 5-phosphate isomerase)|interpro:IPR020672|interpro:IPR037171|mint:P49247|reactome:R-HSA-5659996|reactome:R-HSA-6791461|reactome:R-HSA-71336	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:gddu0Xp/dx4JwbFMs50pQCvvbws9606	rigid:iCahACaxxqmPuEBbVAF5dr9n4WU	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q8IUH3	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-2512147|ensembl:ENSP00000482083|uniprotkb:Q8NFC9|uniprotkb:Q6NYL0	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:rbm45_human(display_long)|uniprotkb:RBM45(gene name)|psi-mi:RBM45(display_short)|uniprotkb:DRB1(gene name synonym)|uniprotkb:DRBP1(gene name synonym)|uniprotkb:RNA-binding motif protein 45(gene name synonym)|uniprotkb:Developmentally-regulated RNA-binding protein 1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511170|imex:IM-28561-1669	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	ensembl:ENSG00000155636(gene)|ensembl:ENST00000616198(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0007399"(nervous system development)|go:"GO:0030154"(cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033101|interpro:IPR034203|interpro:IPR034206|interpro:IPR034207|interpro:IPR034208|interpro:IPR035979|mint:Q8IUH3|rcsb pdb:7CSX|rcsb pdb:7CSZ|go:"GO:0005634"(nucleus)|refseq:NP_694453.2|refseq:XP_005246344.1|refseq:XP_016858811.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:8w7mWJ1ncdOyq9VCGIIYK3qapxY9606	rigid:WOT0OM/6CTZAoiI0cOYJfzabnss	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q5T8P6	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-3232077|intact:EBI-28971938|ensembl:ENSP00000387531|uniprotkb:Q2NKQ2|uniprotkb:Q5T8P5|uniprotkb:Q96SZ3|uniprotkb:Q9P1G7|uniprotkb:Q5CZH8|uniprotkb:Q2NKM2|uniprotkb:Q96K92|uniprotkb:Q9H7F9|uniprotkb:Q5U5P5|uniprotkb:Q5W0G7|uniprotkb:B4DZE0|uniprotkb:Q8N3H5|uniprotkb:Q9H2F8|uniprotkb:Q5T8P8	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:rbm26_human(display_long)|uniprotkb:RBM26(gene name)|psi-mi:RBM26(display_short)|uniprotkb:C13orf10(gene name synonym)|uniprotkb:CTCL tumor antigen se70-2(gene name synonym)|uniprotkb:RNA-binding motif protein 26(gene name synonym)|uniprotkb:PRO1777(orf name)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511163|imex:IM-28561-529	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_001273560.1|refseq:NP_001273561.1|ensembl:ENST00000267229|ensembl:ENSP00000267229|ensembl:ENST00000438724|ensembl:ENSP00000390222|ensembl:ENSP00000387531|ensembl:ENSG00000139746(gene)|ensembl:ENST00000438737(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006397"(mRNA processing)|go:"GO:0046872"(metal ion binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR000571(Zinc finger, CCCH-type)|interpro:IPR002483(Splicing factor PWI)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034859|interpro:IPR034861|interpro:IPR035979|interpro:IPR039511|mint:Q5T8P6|refseq:XP_011533490.1|refseq:XP_011533494.1|refseq:XP_011533495.1|refseq:NP_071401.3	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:ev/6xzYozxNVSp4UJZBVgA7snZc9606	rigid:LjbRC0gbjiEH+MTXYJhyz9kacOI	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q86SE5	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-741520|uniprotkb:Q6ZW87|uniprotkb:Q8N1C2|uniprotkb:B3KTH2|ensembl:ENSP00000428667|ensembl:ENSP00000430367|ensembl:ENSP00000430394|uniprotkb:G3V129	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:ralyl_human(display_long)|uniprotkb:Heterogeneous nuclear ribonucleoprotein C-like 3(gene name synonym)|uniprotkb:RALYL(gene name)|psi-mi:RALYL(display_short)|uniprotkb:HNRPCL3(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511154|imex:IM-28561-1167	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_001093861.1|refseq:NP_001093862.1|refseq:NP_001093863.1|refseq:NP_776247.3|ensembl:ENSG00000184672(gene)|ensembl:ENST00000521268(transcript)|ensembl:ENST00000521695(transcript)|ensembl:ENST00000522455(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0042802"(identical protein binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR017347(Heterogeneous nuclear ribonucleoprotein C, Raly)|interpro:IPR034504|interpro:IPR035979|mint:Q86SE5|refseq:NP_001274173.1|refseq:XP_016868548.1|refseq:XP_016868549.1|refseq:XP_016868550.1|refseq:XP_016868551.1|refseq:XP_016868552.1|refseq:XP_016868553.1|refseq:XP_016868554.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:/dJc0rSACk93SMMAkFSfi2YdWuo9606	rigid:DdZeCrvwfkrtKM3r6jy3z54cU9s	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q9UI14	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-712367|ensembl:ENSP00000222008|uniprotkb:Q7Z4Y2|uniprotkb:Q9Y3R1	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:praf1_human(display_long)|uniprotkb:PRA1 family protein 1(gene name synonym)|uniprotkb:RABAC1(gene name)|psi-mi:RABAC1(display_short)|uniprotkb:PRA1(gene name synonym)|uniprotkb:PRAF1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511147|imex:IM-28561-727	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_006414.2|ensembl:ENSG00000105404(gene)|ensembl:ENST00000222008(transcript)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0070064"(proline-rich region binding)|interpro:IPR004895(Prenylated rab acceptor PRA1)|mint:Q9UI14	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:WS2rUY7yXRbR7pqWgfUCbnEiDbg9606	rigid:Zpz9oqAmtr2KHZ5wIvsyeuxooAQ	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q53H96	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-2959680|ensembl:ENSP00000480945|ensembl:ENSP00000488371|uniprotkb:Q9H896|uniprotkb:Q8N3N9|uniprotkb:B3KMB5|uniprotkb:Q96HX4|uniprotkb:B4DVT6|uniprotkb:H0Y6C3	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:p5cr3_human(display_long)|uniprotkb:PYCR3(gene name)|psi-mi:PYCR3(display_short)|uniprotkb:PYCRL(gene name synonym)|uniprotkb:Pyrroline-5-carboxylate reductase-like protein(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511138|imex:IM-28561-725	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	ensembl:ENST00000495276(transcript)|ensembl:ENST00000632107(transcript)|go:"GO:0004735"(pyrroline-5-carboxylate reductase activity)|go:"GO:0005829"(cytosol)|go:"GO:0045171"(intercellular bridge)|go:"GO:0055129"(L-proline biosynthetic process)|go:"GO:0072686"(mitotic spindle)|interpro:IPR000304(Delta 1-pyrroline-5-carboxylate reductase)|interpro:IPR008927(6-phosphogluconate dehydrogenase, C-terminal-like)|interpro:IPR028939|interpro:IPR029036|interpro:IPR036291|mint:Q53H96|reactome:R-HSA-8964539|ensembl:ENSG00000276657(gene)|ensembl:ENSG00000104524(gene)|refseq:NP_075566.2|refseq:NP_001316795.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:n2snI64kwT1vICZ4DA9tmdtS4vU9606	rigid:dbI8vOV03yyK8VKw+Ra11NWyFgs	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51116	uniprotkb:O75398	intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113	intact:EBI-718185|uniprotkb:O15152|uniprotkb:O75399|uniprotkb:O75510|uniprotkb:O75511|uniprotkb:O75512|uniprotkb:O75513|uniprotkb:Q9UET1|uniprotkb:A8K5R8|uniprotkb:A8K1F8|uniprotkb:C7T5V5|intact:EBI-28974412|ensembl:ENSP00000371846	psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym)	psi-mi:deaf1_human(display_long)|uniprotkb:Nuclear DEAF-1-related transcriptional regulator(gene name synonym)|uniprotkb:Suppressin(gene name synonym)|uniprotkb:Zinc finger MYND domain-containing protein 5(gene name synonym)|uniprotkb:DEAF1(gene name)|psi-mi:DEAF1(display_short)|uniprotkb:SPN(gene name synonym)|uniprotkb:ZMYND5(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511716|imex:IM-28561-1193	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z	refseq:NP_066288.2|ensembl:ENSP00000371846|refseq:NP_001280563.1|ensembl:ENSG00000177030(gene)|ensembl:ENST00000382409(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001650"(fibrillar center)|go:"GO:0001843"(neural tube closure)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007281"(germ cell development)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0033599"(regulation of mammary gland epithelial cell proliferation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0048706"(embryonic skeletal system development)|interpro:IPR000770(SAND)|interpro:IPR002893(Zinc finger, MYND-type)|interpro:IPR010919(SAND-like)|interpro:IPR024119|mint:O75398|rcsb pdb:2JW6|rcsb pdb:4A24|rcsb pdb:5UWW	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606	rogid:2wVDKJ2CcROUYc5whZI3JWATnI89606	rigid:fC82qmCgQpY/UKEuLV4pDU/3gds	false	sufficient binding region:235-370	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51116	uniprotkb:Q16760	intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113	intact:EBI-719333|uniprotkb:Q14158|uniprotkb:Q6PK55|uniprotkb:Q8NG53|ensembl:ENSP00000264057|ensembl:ENSP00000487220	psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym)	psi-mi:dgkd_human(display_long)|uniprotkb:Diglyceride kinase delta(gene name synonym)|uniprotkb:130 kDa diacylglycerol kinase(gene name synonym)|uniprotkb:DGKD(gene name)|psi-mi:DGKD(display_short)|uniprotkb:KIAA0145(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511725|imex:IM-28561-315	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z	refseq:NP_003639.2|refseq:NP_690618.2|ensembl:ENSG00000077044(gene)|ensembl:ENSG00000280873(gene)|ensembl:ENST00000264057(transcript)|ensembl:ENST00000628356(transcript)|go:"GO:0003951"(NAD+ kinase activity)|go:"GO:0004143"(diacylglycerol kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006654"(phosphatidic acid biosynthetic process)|go:"GO:0006897"(endocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007275"(multicellular organism development)|go:"GO:0010033"(response to organic substance)|go:"GO:0015031"(protein transport)|go:"GO:0019900"(kinase binding)|go:"GO:0019932"(second-messenger-mediated signaling)|go:"GO:0019992"(diacylglycerol binding)|go:"GO:0030168"(platelet activation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046339"(diacylglycerol metabolic process)|go:"GO:0046834"(lipid phosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0090038"(negative regulation of protein kinase C signaling)|go:"GO:2000370"(positive regulation of clathrin-dependent endocytosis)|interpro:IPR000756(Diacylglycerol kinase accessory region)|interpro:IPR001206(Diacylglycerol kinase, catalytic region)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR016064(ATP-NAD kinase, PpnK-type)|interpro:IPR017438(ATP-NAD kinase, PpnK-type, alpha/beta)|interpro:IPR037606|interpro:IPR037607|mint:Q16760|rcsb pdb:1R79|rcsb pdb:3BQ7|reactome:R-HSA-114508|dip:DIP-29646N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606	rogid:rMLPKsHWpeF6qbY0eBQcCeFyMo09606	rigid:7T7OZau6ER+GPT2b3G86ItMDexo	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51116	uniprotkb:Q13561	intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113	intact:EBI-715074|uniprotkb:Q86YN2|uniprotkb:Q9BW17|uniprotkb:B2RBK5|ensembl:ENSP00000447824	psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym)	psi-mi:dctn2_human(display_long)|uniprotkb:Dynactin complex 50 kDa subunit(gene name synonym)|uniprotkb:50 kDa dynein-associated polypeptide(gene name synonym)|uniprotkb:p50 dynamitin(gene name synonym)|uniprotkb:DCTN2(gene name)|psi-mi:DCTN2(display_short)|uniprotkb:DCTN50(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511698|imex:IM-28561-1191	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z	refseq:NP_006391.1|refseq:NP_001248341.1|refseq:NP_001248342.1|dip:DIP-37545N|reactome:R-HSA-2565942|reactome:R-HSA-3371497|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-6807878|reactome:R-HSA-6811436|reactome:R-HSA-8854518|ensembl:ENSG00000175203(gene)|ensembl:ENST00000548249(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005869"(dynactin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030286"(dynein complex)|go:"GO:0030426"(growth cone)|go:"GO:0030507"(spectrin binding)|go:"GO:0031982"(vesicle)|go:"GO:0032402"(melanosome transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071539"(protein localization to centrosome)|interpro:IPR028133|mint:Q13561|reactome:R-HSA-2132295	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606	rogid:JrL5jUtArek+zqmCkPKomnjuSf09606	rigid:7o+cFZcLDGmFjtHpwPnDUBQTF/Q	false	sufficient binding region:235-370	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51116	uniprotkb:P32321	intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113	intact:EBI-739870|uniprotkb:Q9BVD8|uniprotkb:B2R836|uniprotkb:Q5M7Z8|uniprotkb:D3DP49|uniprotkb:D3DP50|ensembl:ENSP00000398194|ensembl:ENSP00000424017	psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym)	psi-mi:dctd_human(display_long)|uniprotkb:DCTD(gene name)|psi-mi:DCTD(display_short)|uniprotkb:dCMP deaminase(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511689|imex:IM-28561-751	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z	refseq:NP_001012750.1|refseq:NP_001912.2|ensembl:ENSG00000129187(gene)|ensembl:ENST00000438320(transcript)|ensembl:ENST00000510370(transcript)|go:"GO:0004132"(dCMP deaminase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006220"(pyrimidine nucleotide metabolic process)|go:"GO:0006226"(dUMP biosynthetic process)|go:"GO:0006231"(dTMP biosynthetic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0042802"(identical protein binding)|interpro:IPR002125(CMP/dCMP deaminase, zinc-binding)|interpro:IPR015517(Cytidine deaminase)|interpro:IPR016192(APOBEC/CMP deaminase, zinc-binding)|interpro:IPR016193(Cytidine deaminase-like)|interpro:IPR016473(dCMP deaminase)|interpro:IPR035105|mint:P32321|rcsb pdb:2W4L|reactome:R-HSA-499943|refseq:XP_005262836.1|refseq:XP_005262837.1|refseq:XP_011529976.1|refseq:XP_016863305.1|refseq:XP_016863306.1|refseq:XP_016863307.1|refseq:XP_016863308.1|refseq:XP_016863309.1|refseq:XP_016863310.1|refseq:XP_016863311.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606	rogid:lU3gEi7XdIJbuPlMkForbVKEOyY9606	rigid:GzvC1M9Rowh9amf6uTRiBRkX6DI	false	sufficient binding region:235-370	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51116	uniprotkb:P67870	intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113	intact:EBI-348169|ensembl:ENSP00000365025|ensembl:ENSP00000365026|ensembl:ENSP00000365042|ensembl:ENSP00000372919|ensembl:ENSP00000372925|ensembl:ENSP00000382980|ensembl:ENSP00000390900|ensembl:ENSP00000391038|ensembl:ENSP00000393756|ensembl:ENSP00000394855|ensembl:ENSP00000395275|ensembl:ENSP00000400188|ensembl:ENSP00000407018|ensembl:ENSP00000407379|ensembl:ENSP00000409510|ensembl:ENSP00000410802|ensembl:ENSP00000411322|ensembl:ENSP00000412520|ensembl:ENSP00000413469|ensembl:ENSP00000415237|ensembl:ENSP00000415303|uniprotkb:P07312|uniprotkb:P13862|uniprotkb:Q4VX47|intact:EBI-3866975|uniprotkb:B0UXA9	psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym)	psi-mi:csk2b_human(display_long)|uniprotkb:Phosvitin(gene name synonym)|uniprotkb:Protein G5a(gene name synonym)|uniprotkb:CSNK2B(gene name)|psi-mi:CSNK2B(display_short)|uniprotkb:CK2N(gene name synonym)|uniprotkb:G5A(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511682|imex:IM-28561-313	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z	ensembl:ENSG00000204435(gene)|ensembl:ENSG00000230700(gene)|ensembl:ENSG00000206406(gene)|ensembl:ENSG00000232960(gene)|ensembl:ENSG00000224398(gene)|ensembl:ENSG00000224774(gene)|ensembl:ENSG00000228875(gene)|ensembl:ENST00000375882(transcript)|ensembl:ENST00000383427(transcript)|ensembl:ENST00000383433(transcript)|ensembl:ENST00000400110(transcript)|ensembl:ENST00000412802(transcript)|ensembl:ENST00000418230(transcript)|ensembl:ENST00000422567(transcript)|ensembl:ENST00000429633(transcript)|ensembl:ENST00000431476(transcript)|ensembl:ENST00000436169(transcript)|ensembl:ENST00000443673(transcript)|ensembl:ENST00000448596(transcript)|ensembl:ENST00000451917(transcript)|ensembl:ENST00000452985(transcript)|ensembl:ENST00000453234(transcript)|ensembl:ENST00000454382(transcript)|ensembl:ENST00000454511(transcript)|ensembl:ENST00000455161(transcript)|ensembl:ENST00000458330(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0005956"(protein kinase CK2 complex)|go:"GO:0007165"(signal transduction)|ensembl:ENST00000375865(transcript)|ensembl:ENST00000375866(transcript)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016363"(nuclear matrix)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032927"(positive regulation of activin receptor signaling pathway)|go:"GO:0033211"(adiponectin-activated signaling pathway)|go:"GO:0033574"(response to testosterone)|go:"GO:0034622"|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0046872"(metal ion binding)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0061154"(endothelial tube morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0080163"(regulation of protein serine/threonine phosphatase activity)|go:"GO:0097421"(liver regeneration)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000704(Casein kinase II, regulatory subunit)|interpro:IPR016149(Casein kinase II, regulatory subunit, alpha-helical)|interpro:IPR035991|mint:P67870|rcsb pdb:1DS5|rcsb pdb:1JWH|go:"GO:0008134"(transcription factor binding)|rcsb pdb:1QF8|rcsb pdb:3EED|rcsb pdb:4DGL|rcsb pdb:4MD7|rcsb pdb:4MD8|rcsb pdb:4MD9|rcsb pdb:4NH1|reactome:R-HSA-1483191|reactome:R-HSA-201688|reactome:R-HSA-2514853|reactome:R-HSA-445144|reactome:R-HSA-6798695|reactome:R-HSA-6804756|reactome:R-HSA-6814122|reactome:R-HSA-8932339|reactome:R-HSA-8934903|reactome:R-HSA-8939243|reactome:R-HSA-8948751|rcsb pdb:6Q38|refseq:NP_001311.3|refseq:NP_001269314.1|dip:DIP-131N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606	rogid:ZTHJjCqHg2dE7B+WoSU28VSMuPg9606	rigid:5wzx/VxZIv/saM9oa28ZunG7dyg	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51116	uniprotkb:P21964	intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113	intact:EBI-372265|uniprotkb:Q6IB07|uniprotkb:Q6ICE6|uniprotkb:A8MPV9|intact:EBI-743305|uniprotkb:Q9BWC7|intact:EBI-11576026|ensembl:ENSP00000354511|ensembl:ENSP00000384654|ensembl:ENSP00000385150|ensembl:ENSP00000385917|ensembl:ENSP00000503583|ensembl:ENSP00000503719|ensembl:ENSP00000504402	psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym)	psi-mi:comt_human(display_long)|uniprotkb:COMT(gene name)|psi-mi:COMT(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511673|imex:IM-28561-973	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z	refseq:NP_000745.1|refseq:NP_001128633.1|refseq:NP_001128634.1|refseq:NP_009294.1|refseq:XP_016884083.1|refseq:XP_016884084.1|ensembl:ENSG00000093010(gene)|ensembl:ENST00000361682(transcript)|ensembl:ENST00000403710(transcript)|ensembl:ENST00000406520(transcript)|ensembl:ENST00000407537(transcript)|ensembl:ENST00000676678(transcript)|ensembl:ENST00000678255(transcript)|ensembl:ENST00000678868(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007565"(female pregnancy)|go:"GO:0007612"(learning)|go:"GO:0007614"(short-term memory)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0008171"(O-methyltransferase activity)|go:"GO:0008210"(estrogen metabolic process)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016036"(cellular response to phosphate starvation)|go:"GO:0016206"(catechol O-methyltransferase activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0032259"(methylation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032502"(developmental process)|go:"GO:0035814"(negative regulation of renal sodium excretion)|go:"GO:0042135"(neurotransmitter catabolic process)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042420"(dopamine catabolic process)|go:"GO:0042424"(catecholamine catabolic process)|go:"GO:0042493"|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043627"(response to estrogen)|go:"GO:0044297"(cell body)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045963"(negative regulation of dopamine metabolic process)|go:"GO:0048265"(response to pain)|go:"GO:0048609"(multicellular organismal reproductive process)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050668"(positive regulation of homocysteine metabolic process)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0070062"(extracellular exosome)|go:"GO:0102084"(L-dopa O-methyltransferase activity)|go:"GO:0102938"(orcinol O-methyltransferase activity)|interpro:IPR002935(O-methyltransferase, family 3)|interpro:IPR017128(Catechol O-methyltransferase, eukaryotic)|interpro:IPR029063|mint:P21964|rcsb pdb:3A7E|rcsb pdb:3BWM|rcsb pdb:3BWY|rcsb pdb:4PYI|rcsb pdb:4PYJ|rcsb pdb:4PYK|rcsb pdb:4XUD|rcsb pdb:4XUE|rcsb pdb:5LSA|rcsb pdb:6I3C|rcsb pdb:6I3D|reactome:R-HSA-156581|reactome:R-HSA-379397|reactome:R-HSA-379398|reactome:R-HSA-9679191|rcsb pdb:4XUC	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606	rogid:3Fnq8iVqPpOWNX6QQuiNRSsTFN09606	rigid:QnuDasb40BR80d4ZirkMJWCTDDM	false	sufficient binding region:235-370	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51116	uniprotkb:Q9H2X0	intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113	intact:EBI-947551|intact:EBI-1752274|uniprotkb:O95254|uniprotkb:Q2M1I8|uniprotkb:Q6UW83|uniprotkb:Q9H2D3|uniprotkb:Q9H2W8|uniprotkb:Q9H2W9|uniprotkb:Q9P0Z2|uniprotkb:Q9P0Z3|uniprotkb:Q9P0Z4|uniprotkb:Q9P0Z5|intact:EBI-1957537|ensembl:ENSP00000204604	psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym)	psi-mi:chrd_human(display_long)|uniprotkb:CHRD(gene name)|psi-mi:CHRD(display_short)|uniprotkb:UNQ217/PRO243(orf name)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511666|imex:IM-28561-749	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z	refseq:NP_003732.2|refseq:NP_001291401.1|refseq:NP_001291402.1|refseq:NP_001291403.1|dip:DIP-48857N|ensembl:ENSG00000090539(gene)|ensembl:ENST00000204604(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0005615"(extracellular space)|go:"GO:0019955"(cytokine binding)|go:"GO:0021919"(BMP signaling pathway involved in spinal cord dorsal/ventral patterning)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0033504"(floor plate development)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR010895(CHRD)|interpro:IPR016353(Chordin)|mint:Q9H2X0	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606	rogid:Y/WHkB30K8nEcaaL2wyikwWH1kg9606	rigid:Sg2mUMfAhtu1MxuVaADq5Gq5pbg	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51116	uniprotkb:Q53HC0	intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113	intact:EBI-719994|uniprotkb:Q9H697|uniprotkb:B3KNQ0|ensembl:ENSP00000238156|ensembl:ENSP00000488830	psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym)	psi-mi:ccd92_human(display_long)|uniprotkb:Limkain beta-2(gene name synonym)|uniprotkb:CCDC92(gene name)|psi-mi:CCDC92(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511659|imex:IM-28561-311	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z	refseq:NP_079416.1|ensembl:ENSG00000119242(gene)|ensembl:ENSG00000275035(gene)|ensembl:ENST00000238156(transcript)|ensembl:ENST00000632401(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR033224|interpro:IPR039496|interpro:IPR040370|mint:Q53HC0|refseq:NP_001291886.1|refseq:NP_001291887.1|refseq:NP_001291888.1|refseq:NP_001291889.1|refseq:NP_001291890.1|refseq:XP_005253681.1|refseq:XP_016875473.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606	rogid:Iu/FzTqEpzn8N5WUTt1OwoKWxyc9606	rigid:fkKiXihWaSxACWafgWNE+dBoxao	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51116	uniprotkb:P35520	intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113	intact:EBI-740135|uniprotkb:Q99425|uniprotkb:Q9BWC5|uniprotkb:B2R993|uniprotkb:D3DSK4|intact:EBI-14245939|ensembl:ENSP00000344460|ensembl:ENSP00000352643|ensembl:ENSP00000381225|ensembl:ENSP00000381231	psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym)	psi-mi:cbs_human(display_long)|uniprotkb:CBS(gene name)|psi-mi:CBS(display_short)|uniprotkb:Serine sulfhydrase(gene name synonym)|uniprotkb:Beta-thionase(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511652|imex:IM-28561-309	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z	refseq:NP_000062.1|refseq:NP_001171479.1|refseq:NP_001171480.1|ensembl:ENSG00000160200(gene)|ensembl:ENST00000352178(transcript)|ensembl:ENST00000359624(transcript)|ensembl:ENST00000398158(transcript)|go:"GO:0004122"(cystathionine beta-synthase activity)|ensembl:ENST00000398165(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006535"(cysteine biosynthetic process from serine)|go:"GO:0006563"(L-serine metabolic process)|go:"GO:0006565"(L-serine catabolic process)|go:"GO:0019343"(cysteine biosynthetic process via cystathionine)|go:"GO:0019344"(cysteine biosynthetic process)|go:"GO:0019346"(transsulfuration)|go:"GO:0019448"(L-cysteine catabolic process)|go:"GO:0019825"(oxygen binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0020037"(heme binding)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042262"(DNA protection)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043418"(homocysteine catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0050421"("nitrite reductase (NO-forming) activity")|go:"GO:0050667"(homocysteine metabolic process)|go:"GO:0070025"(carbon monoxide binding)|go:"GO:0070026"(nitric oxide binding)|go:"GO:0070814"(hydrogen sulfide biosynthetic process)|go:"GO:0072341"(modified amino acid binding)|go:"GO:1904047"(S-adenosyl-L-methionine binding)|interpro:IPR000644(Cystathionine beta-synthase, core)|interpro:IPR001216(Cysteine synthase/cystathionine beta-synthase P-phosphate-binding site)|interpro:IPR001926(Pyridoxal phosphate-dependent enzyme, beta subunit)|interpro:IPR005857(Cystathionine beta-synthase)|interpro:IPR036052|mint:P35520|rcsb pdb:1JBQ|rcsb pdb:1M54|rcsb pdb:4COO|rcsb pdb:4L0D|rcsb pdb:4L27|rcsb pdb:4L28|rcsb pdb:4L3V|rcsb pdb:4PCU|rcsb pdb:4UUU|rcsb pdb:5MMS|reactome:R-HSA-1614603|reactome:R-HSA-2408508|refseq:XP_011528079.1|refseq:XP_011528083.1|refseq:XP_011528084.1|refseq:XP_011544396.1|refseq:XP_011544397.1|refseq:XP_011544399.1|refseq:XP_011544400.1|refseq:XP_011544401.1|refseq:NP_001307227.1|refseq:NP_001308002.1|refseq:XP_016883700.1|refseq:XP_016883701.1|refseq:XP_016883702.1|refseq:XP_016883703.1|refseq:XP_016883704.1|refseq:XP_016883705.1|refseq:XP_016883706.1|refseq:XP_016883707.1|refseq:XP_016883978.1|refseq:XP_016883979.1|refseq:XP_016883980.1|refseq:XP_016883981.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606	rogid:f9eo0cPOHppVY7Nqejag3YyK18s9606	rigid:GRKkm6bT2ALuZ3vmhj0gTZFTpyM	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51116	uniprotkb:Q14444	intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113	intact:EBI-1047080|uniprotkb:Q15074|intact:EBI-1171814|uniprotkb:Q6IMN4|uniprotkb:A6NMY7|uniprotkb:Q6IMN7|uniprotkb:Q9BV09|intact:EBI-2562858|intact:EBI-3449178|uniprotkb:D3DR06|ensembl:ENSP00000340329|ensembl:ENSP00000434150	psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym)	psi-mi:capr1_human(display_long)|uniprotkb:CAPRIN1(gene name)|psi-mi:CAPRIN1(display_short)|uniprotkb:GPIAP1(gene name synonym)|uniprotkb:GPIP137(gene name synonym)|uniprotkb:M11S1(gene name synonym)|uniprotkb:Cytoplasmic activation- and proliferation-associated protein 1(gene name synonym)|uniprotkb:GPI-anchored membrane protein 1(gene name synonym)|uniprotkb:GPI-anchored protein p137(gene name synonym)|uniprotkb:Cell cycle-associated protein 1(gene name synonym)|uniprotkb:Membrane component chromosome 11 surface marker 1(gene name synonym)|uniprotkb:RNG105(gene name synonym)|uniprotkb:RNA granule protein 105(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511643|imex:IM-28561-971	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z	refseq:NP_005889.3|refseq:NP_976240.1|ensembl:ENSG00000135387(gene)|ensembl:ENST00000341394(transcript)|ensembl:ENST00000532820(transcript)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030027"(lamellipodium)|go:"GO:0030425"(dendrite)|go:"GO:0031252"(cell leading edge)|go:"GO:0045202"(synapse)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|interpro:IPR022070|interpro:IPR028816|interpro:IPR041637|mint:Q14444|rcsb pdb:4WBE|rcsb pdb:4WBP|rcsb pdb:6TA7|refseq:XP_016873238.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606	rogid:3c6ZdBClP/D6jIi8NfzBkMc61pI9606	rigid:zDu8v0UjZqGimAohY74eACmoo1s	false	sufficient binding region:235-370	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51116	uniprotkb:Q13555	intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113	intact:EBI-1383465|uniprotkb:O00561|uniprotkb:Q5SWX4|uniprotkb:Q8NIA4|uniprotkb:O15378|uniprotkb:Q13556|uniprotkb:Q5SQZ3|uniprotkb:Q5SQZ4|uniprotkb:Q8N4I3|uniprotkb:Q13279|uniprotkb:Q13282|uniprotkb:Q7KYX5|uniprotkb:A0A0A0MS52|uniprotkb:A0A0A0MT11	psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym)	psi-mi:kcc2g_human(display_long)|uniprotkb:CAMK(gene name synonym)|uniprotkb:CAMK-II(gene name synonym)|uniprotkb:CAMK2G(gene name)|psi-mi:CAMK2G(display_short)|uniprotkb:CAMKG(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511636|imex:IM-28561-115	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z	refseq:NP_001213.2|refseq:NP_751909.1|refseq:NP_751913.1|refseq:XP_005270260.1|refseq:NP_001307827.1|refseq:NP_001191421.1|dip:DIP-51315N|mint:Q13555|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-877300|reactome:R-HSA-9022692|reactome:R-HSA-936837|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-9620244|reactome:R-HSA-9649948|reactome:R-HSA-9656223|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0004723"(calcium-dependent protein serine/threonine phosphatase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005954"(calcium- and calmodulin-dependent protein kinase complex)|go:"GO:0007399"(nervous system development)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0014733"(regulation of skeletal muscle adaptation)|go:"GO:0016020"(membrane)|go:"GO:0030073"(insulin secretion)|go:"GO:0030154"(cell differentiation)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR032710|rcsb pdb:2UX0|rcsb pdb:2V7O|reactome:R-HSA-111932|reactome:R-HSA-3371571|reactome:R-HSA-399719|reactome:R-HSA-438066|reactome:R-HSA-442729|reactome:R-HSA-442982|reactome:R-HSA-5576892|reactome:R-HSA-5578775|reactome:R-HSA-5673000|reactome:R-HSA-5673001|reactome:R-HSA-6802946	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606	rogid:qtCEps5UkV7tprB2QmjCDK5YyIo9606	rigid:uuDvmTWrjxte5epH1fGUrpOCcfs	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51116	uniprotkb:Q13554	intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113	intact:EBI-1058722|ensembl:ENSP00000379098|uniprotkb:A4D2K1|uniprotkb:A4D2K2|uniprotkb:Q9UGH9|uniprotkb:Q9UNX0|uniprotkb:Q9UNX7|uniprotkb:O95437|uniprotkb:O95438|uniprotkb:Q9UP00|uniprotkb:Q9Y5N4|uniprotkb:Q9Y6F4|uniprotkb:A4D2K0|uniprotkb:O95599|uniprotkb:Q9UGH7|uniprotkb:Q9UGH8|uniprotkb:A4D2K4|uniprotkb:A4D2K6|uniprotkb:A4D2K3|intact:EBI-1383493|uniprotkb:A4D2K5	psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym)	psi-mi:kcc2b_human(display_long)|uniprotkb:CAMK2B(gene name)|psi-mi:CAMK2B(display_short)|uniprotkb:CAM2(gene name synonym)|uniprotkb:CAMKB(gene name synonym)|uniprotkb:CAMK2(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511627|imex:IM-28561-553	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z	ensembl:ENSG00000058404(gene)|ensembl:ENST00000395749(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005954"(calcium- and calmodulin-dependent protein kinase complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014733"(regulation of skeletal muscle adaptation)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|refseq:NP_001211.3|refseq:NP_742075.1|refseq:NP_742076.1|refseq:NP_742077.1|refseq:NP_742078.1|refseq:NP_742079.1|refseq:NP_742080.1|refseq:NP_742081.1|mint:Q13554|rcsb pdb:3BHH|reactome:R-HSA-111932|reactome:R-HSA-3371571|reactome:R-HSA-399719|reactome:R-HSA-438066|reactome:R-HSA-442729|reactome:R-HSA-442982|reactome:R-HSA-5576892|reactome:R-HSA-5578775|reactome:R-HSA-5673000|reactome:R-HSA-5673001|reactome:R-HSA-6802946|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-877300|reactome:R-HSA-9022692|reactome:R-HSA-936837|reactome:R-HSA-9609736|interpro:IPR032710|reactome:R-HSA-9617324|reactome:R-HSA-9620244|reactome:R-HSA-9649948|reactome:R-HSA-9656223|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0051823"(regulation of synapse structural plasticity)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0090129"(positive regulation of synapse maturation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2001222"(regulation of neuron migration)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|refseq:NP_001280099.1|dip:DIP-39770N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606	rogid:3RDzSxLdoGtWTECo9At60gEZfZY9606	rigid:8gJcozRemC45z3tkGLJHPifdI8M	false	sufficient binding region:235-370	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q96H12	uniprotkb:P51116	intact:EBI-8466227|uniprotkb:Q5T728|uniprotkb:Q5T726|uniprotkb:Q5T727|intact:MINT-7032147|uniprotkb:B2RC35|ensembl:ENSP00000378506|ensembl:ENSP00000480445|ensembl:ENSP00000480622	intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113	psi-mi:msd3_human(display_long)|uniprotkb:MSANTD3(gene name)|psi-mi:MSANTD3(display_short)|uniprotkb:C9orf30(gene name synonym)|uniprotkb:L8(orf name)	psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511618|imex:IM-28561-1457	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001185735.1|refseq:NP_001185734.1|refseq:NP_542386.1|refseq:NP_001185736.1|ensembl:ENSG00000066697(gene)|ensembl:ENST00000395067(transcript)|ensembl:ENST00000613183(transcript)|ensembl:ENST00000622639(transcript)|interpro:IPR026709|interpro:IPR028002|mint:Q96H12	interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z	-	comment:mint|comment:homomint	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:JOWl9WQVA131ZH45W9BYNpdEAJU9606	rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606	rigid:YlFbaPtFFv8rtfZT9Q5+Zs//fEU	false	-	sufficient binding region:235-370	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51116	uniprotkb:Q9H165	intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113	intact:EBI-765567|uniprotkb:Q86W14|uniprotkb:Q8WU92|uniprotkb:Q96JL6|uniprotkb:Q9H163|uniprotkb:Q9H164|uniprotkb:Q9H3G9|uniprotkb:Q9NWA7|uniprotkb:D6W5D7|uniprotkb:Q66LN6|ensembl:ENSP00000496168	psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym)	psi-mi:bc11a_human(display_long)|uniprotkb:B-cell CLL/lymphoma 11A(gene name synonym)|uniprotkb:COUP-TF-interacting protein 1(gene name synonym)|uniprotkb:Ecotropic viral integration site 9 protein homolog(gene name synonym)|uniprotkb:BCL11A(gene name)|psi-mi:BCL11A(display_short)|uniprotkb:CTIP1(gene name synonym)|uniprotkb:EVI9(gene name synonym)|uniprotkb:KIAA1809(gene name synonym)|uniprotkb:ZNF856(gene name synonym)|uniprotkb:Zinc finger protein 856(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511611|imex:IM-28561-551	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z	refseq:NP_060484.2|refseq:NP_075044.2|refseq:NP_612569.1|refseq:XP_011531211.1|refseq:XP_016859823.1|dip:DIP-45629N|ensembl:ENSG00000119866(gene)|ensembl:ENST00000642384(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001067"(transcription regulatory region nucleic acid binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0032463"(negative regulation of protein homooligomerization)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048671"(negative regulation of collateral sprouting)|go:"GO:0048672"(positive regulation of collateral sprouting)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:1903860"(negative regulation of dendrite extension)|go:"GO:1904800"(negative regulation of neuron remodeling)|go:"GO:1905232"(cellular response to L-glutamate)|go:"GO:2000171"(negative regulation of dendrite development)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:Q9H165|rcsb pdb:5VTB|rcsb pdb:6KI6|rcsb pdb:6U9Q|go:"GO:2000173"(negative regulation of branching morphogenesis of a nerve)	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606	rogid:xASsLQWykg/7ZpyjLsQP8GlQ/H09606	rigid:wfcd6FoU66Um0hGxdZ/hlFo9sCg	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51116	uniprotkb:O14874	intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113	intact:EBI-1046765|uniprotkb:Q96IN5|uniprotkb:Q6FGL4|intact:EBI-1210327|uniprotkb:A8MY43|uniprotkb:Q96G95|ensembl:ENSP00000219794|ensembl:ENSP00000378405	psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym)	psi-mi:bckd_human(display_long)|uniprotkb:Branched-chain alpha-ketoacid dehydrogenase kinase(gene name synonym)|uniprotkb:BCKDK(gene name)|psi-mi:BCKDK(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511602|imex:IM-28561-747	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z	refseq:NP_005872.2|go:"GO:0005947"(mitochondrial alpha-ketoglutarate dehydrogenase complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006550"(isoleucine catabolic process)|go:"GO:0006552"(leucine catabolic process)|go:"GO:0006574"(valine catabolic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0009063"(cellular amino acid catabolic process)|go:"GO:0009083"(branched-chain amino acid catabolic process)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0045763"(negative regulation of cellular amino acid metabolic process)|go:"GO:0047323"("[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity")|interpro:IPR003594(ATP-binding region, ATPase-like)|refseq:NP_001116429.1|refseq:NP_001258855.1|interpro:IPR004358(Signal transduction histidine kinase-related protein, C-terminal)|interpro:IPR005467(Signal transduction histidine kinase, core)|interpro:IPR018955|go:"GO:0005759"(mitochondrial matrix)|interpro:IPR036784|interpro:IPR036890|interpro:IPR039028|mint:O14874|reactome:R-HSA-70895|ensembl:ENSG00000103507(gene)|ensembl:ENST00000219794(transcript)|ensembl:ENST00000394951(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004740"("pyruvate dehydrogenase (acetyl-transferring) kinase activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606	rogid:0hiSb7/qtSPoHt/cmLnUo7Gq6OI9606	rigid:yI8dbIOkiJV0uoFoi6qqeUq8N7A	false	sufficient binding region:235-370	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51116	uniprotkb:Q9Y2T1	intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113	intact:EBI-4400025|uniprotkb:Q3MJ88|uniprotkb:Q9H3M6|uniprotkb:Q9UH84|ensembl:ENSP00000302625	psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym)	psi-mi:axin2_human(display_long)|uniprotkb:AXIN2(gene name)|psi-mi:AXIN2(display_short)|uniprotkb:Axin-like protein(gene name synonym)|uniprotkb:Axis inhibition protein 2(gene name synonym)|uniprotkb:Conductin(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511593|imex:IM-28561-549	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z	refseq:NP_004646.3|dip:DIP-59293N|ensembl:ENSG00000168646(gene)|ensembl:ENST00000307078(transcript)|go:"GO:0001756"(somitogenesis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001957"(intramembranous ossification)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003413"(chondrocyte differentiation involved in endochondral bone morphogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0030282"(bone mineralization)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032423"(regulation of mismatch repair)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042476"(odontogenesis)|go:"GO:0043570"(maintenance of DNA repeat elements)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0061181"(regulation of chondrocyte development)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070602"(regulation of centromeric sister chromatid cohesion)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR001158(DIX)|interpro:IPR014936(Axin beta-catenin binding)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR029071|interpro:IPR032101|interpro:IPR036305|interpro:IPR038207|interpro:IPR043581|mint:Q9Y2T1|reactome:R-HSA-201681|reactome:R-HSA-4411364|reactome:R-HSA-4641257|reactome:R-HSA-5689880	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606	rogid:Tz6ggQ7gnpx/kUUmlEUumOQjJvI9606	rigid:WBleagiR5wXGqOfzFAz3pLdZCU0	false	sufficient binding region:235-370	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51116	uniprotkb:O15169	intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113	intact:EBI-710484|uniprotkb:Q4TT26|uniprotkb:Q4TT27|ensembl:ENSP00000262320|uniprotkb:Q86YA7|uniprotkb:Q8WVW6|uniprotkb:Q96S28	psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym)	psi-mi:axin1_human(display_long)|uniprotkb:Axis inhibition protein 1(gene name synonym)|uniprotkb:AXIN1(gene name)|psi-mi:AXIN1(display_short)|uniprotkb:AXIN(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511584|imex:IM-28561-547	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z	refseq:NP_003493.1|refseq:NP_851393.1|ensembl:ENSG00000103126(gene)|ensembl:ENST00000262320(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034622"|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046332"(SMAD binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0071944"(cell periphery)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR001158(DIX)|interpro:IPR014936(Axin beta-catenin binding)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR029071|interpro:IPR029797|interpro:IPR032101|interpro:IPR036305|interpro:IPR038207|interpro:IPR043581|mint:O15169|rcsb pdb:1DK8|rcsb pdb:1EMU|rcsb pdb:1O9U|rcsb pdb:3ZDI|rcsb pdb:4B7T|rcsb pdb:4NM0|rcsb pdb:4NM3|rcsb pdb:4NM5|rcsb pdb:4NM7|rcsb pdb:4NU1|rcsb pdb:5WZZ|rcsb pdb:6JCK|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-201681|reactome:R-HSA-4641257|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5689880|reactome:R-HSA-8931987|reactome:R-HSA-8939256|reactome:R-HSA-9018519|dip:DIP-34630N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606	rogid:uO+LxY/7ibIZqdd5onbfXqGAZeo9606	rigid:LKpZXspBQq4kpnjbV9P9kOYGzMY	false	sufficient binding region:235-370	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51116	uniprotkb:P54259	intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113	intact:EBI-945980|uniprotkb:Q99495|uniprotkb:Q99621|uniprotkb:Q9UEK7|ensembl:ENSP00000349076|ensembl:ENSP00000379915	psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym)	psi-mi:atn1_human(display_long)|uniprotkb:ATN1(gene name)|psi-mi:ATN1(display_short)|uniprotkb:DRPLA(gene name synonym)|uniprotkb:Dentatorubral-pallidoluysian atrophy protein(gene name synonym)|uniprotkb:D12S755E(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511575|imex:IM-28561-969	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z	refseq:NP_001007027.1|refseq:NP_001931.2|ensembl:ENSP00000349076|ensembl:ENSP00000379915|dip:DIP-29423N|ensembl:ENSG00000111676(gene)|ensembl:ENST00000356654(transcript)|ensembl:ENST00000396684(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0007417"(central nervous system development)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030054"(cell junction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|interpro:IPR002951(Atrophin)|interpro:IPR017993|mint:P54259|reactome:R-HSA-8943724	-	-	crc64:B47603486C672637	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606	rogid:SX8MuZ4aW8/PJmQl4HqY+NOSxbI9606	rigid:Q8qEYH3tfMsBgPjasYeQqKnK9r4	false	sufficient binding region:235-370	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q96S55	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-2513471|ensembl:ENSP00000370150|ensembl:ENSP00000477551|uniprotkb:Q9NRJ6|uniprotkb:Q5W0E2|uniprotkb:Q53EP6|uniprotkb:Q8WV26|uniprotkb:Q5W0E4|uniprotkb:Q59ET8|uniprotkb:Q9H681|uniprotkb:B2RDB0	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:wrip1_human(display_long)|uniprotkb:WRNIP1(gene name)|psi-mi:WRNIP1(display_short)|uniprotkb:WHIP(gene name synonym)|uniprotkb:Werner helicase-interacting protein 1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511520|imex:IM-28561-113	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	ensembl:ENSG00000124535(gene)|ensembl:ENST00000380773(transcript)|ensembl:ENST00000618555(transcript)|go:"GO:0000731"(DNA synthesis involved in DNA repair)|go:"GO:0003677"(DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0016020"(membrane)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0030174"(regulation of DNA-dependent DNA replication initiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR006642(Zinc finger, Rad18-type putative)|interpro:IPR008921(DNA polymerase III clamp loader subunit, C-terminal)|interpro:IPR021886|interpro:IPR027417|interpro:IPR032423|interpro:IPR040539|mint:Q96S55|rcsb pdb:3VHS|rcsb pdb:3VHT|go:"GO:0017116"(single-stranded DNA helicase activity)|refseq:NP_064520.2|refseq:NP_569079.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:Q8qVSqItgTO7sbWGAQ3XAoFFUr89606	rigid:byJVZ+k2X3mO67L+DkxeOB4Iwzk	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q9NQA3	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-9846564|uniprotkb:A6NGF1|uniprotkb:Q8N305|intact:EBI-28979423	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:wash6_human(display_long)|uniprotkb:WASH6P(gene name)|psi-mi:WASH6P(display_short)|uniprotkb:CXYorf1(gene name synonym)|uniprotkb:FAM39A(gene name synonym)|uniprotkb:Protein FAM39A(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511511|imex:IM-28561-745	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	interpro:IPR028290|interpro:IPR021854|mint:Q9NQA3|go:"GO:0003779"(actin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0016197"(endosomal transport)|go:"GO:0031901"(early endosome membrane)|go:"GO:0034314"(Arp2/3 complex-mediated actin nucleation)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0071203"(WASH complex)	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:WFinmhG9sW8cuYKHW5sitOj6a9k9606	rigid:WqAULN4f7hyLczRN0DnQfwfbfb4	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:P04275	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-981819|uniprotkb:Q8TCE8|uniprotkb:Q99806|ensembl:ENSP00000261405	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:vwf_human(display_long)|uniprotkb:VWF(gene name)|psi-mi:VWF(display_short)|uniprotkb:F8VWF(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511502|imex:IM-28561-1189	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_000543.2|ensembl:ENSG00000110799(gene)|ensembl:ENST00000261405(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007155"(cell adhesion)|go:"GO:0007596"(blood coagulation)|go:"GO:0007599"(hemostasis)|go:"GO:0009611"(response to wounding)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0030168"(platelet activation)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0033093"(Weibel-Palade body)|go:"GO:0042802"(identical protein binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051087"(chaperone binding)|dip:DIP-29667N|reactome:R-HSA-9672391|reactome:R-HSA-9672393|rcsb pdb:5BV8|rcsb pdb:6FWN|rcsb pdb:6N29|rcsb pdb:7KWO|go:"GO:0062023"(collagen-containing extracellular matrix)|reactome:R-HSA-114608|reactome:R-HSA-140837|reactome:R-HSA-216083|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-430116|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-75892|reactome:R-HSA-76009|rcsb pdb:4NT5|reactome:R-HSA-9649948|reactome:R-HSA-9656223|go:"GO:1902533"(positive regulation of intracellular signal transduction)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR001846(von Willebrand factor, type D)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR002919(Protease inhibitor I8, cysteine-rich trypsin inhibitor-like)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR014853(Region of unknown function DUF1787)|interpro:IPR032361|interpro:IPR036084|interpro:IPR036465|interpro:IPR037578|mint:P04275|rcsb pdb:1AO3|rcsb pdb:1ATZ|rcsb pdb:1AUQ|rcsb pdb:1FE8|rcsb pdb:1FNS|rcsb pdb:1IJB|rcsb pdb:1IJK|rcsb pdb:1M10|rcsb pdb:1OAK|rcsb pdb:1SQ0|rcsb pdb:1U0N|rcsb pdb:1UEX|rcsb pdb:2ADF|rcsb pdb:2MHP|rcsb pdb:2MHQ|rcsb pdb:3GXB|rcsb pdb:3HXO|rcsb pdb:3HXQ|rcsb pdb:3PPV|go:"GO:0070062"(extracellular exosome)|rcsb pdb:3PPW|rcsb pdb:3PPX|rcsb pdb:3PPY|rcsb pdb:3ZQK|rcsb pdb:4C29|rcsb pdb:4C2A|rcsb pdb:4C2B|rcsb pdb:4DMU	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:yeGxC2SyyvUZ3hNciww1o8TmY5Q9606	rigid:wwo/HFbTn15bp8kIpDDvBK0x9jo	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:P08670	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-353844|uniprotkb:Q15867|uniprotkb:Q15868|uniprotkb:Q15869|uniprotkb:Q548L2|uniprotkb:Q6LER9|uniprotkb:Q8N850|uniprotkb:Q96ML2|uniprotkb:Q9NTM3|uniprotkb:B0YJC2|intact:EBI-3442369|uniprotkb:D3DRU4|ensembl:ENSP00000224237|ensembl:ENSP00000446007	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:vime_human(display_long)|uniprotkb:VIM(gene name)|psi-mi:VIM(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511493|imex:IM-28561-1187	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_003371.2|ensembl:ENSG00000026025(gene)|ensembl:ENST00000224237(transcript)|ensembl:ENST00000544301(transcript)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005212"(structural constituent of eye lens)|go:"GO:0005737"(cytoplasm)|go:"GO:0005777"(peroxisome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014002"(astrocyte development)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031252"(cell leading edge)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0070307"(lens fiber cell development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071225"(cellular response to muramyl dipeptide)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1990254"(keratin filament binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|interpro:IPR027699|interpro:IPR039008|mint:P08670|rcsb pdb:1GK4|rcsb pdb:1GK6|rcsb pdb:1GK7|rcsb pdb:3G1E|rcsb pdb:3KLT|rcsb pdb:3S4R|rcsb pdb:3SSU|rcsb pdb:3SWK|rcsb pdb:3TRT|rcsb pdb:3UF1|rcsb pdb:4MCY|rcsb pdb:4MCZ|rcsb pdb:4MD0|rcsb pdb:4MD5|rcsb pdb:4MDI|rcsb pdb:4MDJ|rcsb pdb:4YPC|rcsb pdb:4YV3|rcsb pdb:5WHF|rcsb pdb:6ATF|rcsb pdb:6ATI|rcsb pdb:6BIR|rcsb pdb:6YXK|reactome:R-HSA-264870|reactome:R-HSA-390522|reactome:R-HSA-6785807|reactome:R-HSA-9013422|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9646399|refseq:XP_006717563.1|dip:DIP-32507N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:GhAhVuXMNxi6P5J0CfNi5l9bjRk9606	rigid:DPEg9xQzeHJu9OVR2Uf+GVe9rsg	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q8NBZ7	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-2843986|uniprotkb:Q9H5C2|uniprotkb:Q8NBX3|ensembl:ENSP00000387019	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:uxs1_human(display_long)|uniprotkb:UXS1(gene name)|psi-mi:UXS1(display_short)|uniprotkb:UDP-glucuronate decarboxylase 1(gene name synonym)|uniprotkb:UNQ2538/PRO6079(orf name)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511484|imex:IM-28561-967	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_079352.2|refseq:NP_001240804.1|refseq:NP_001240805.1|refseq:XP_016860503.1|ensembl:ENSG00000115652(gene)|ensembl:ENST00000409501(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0033320"(UDP-D-xylose biosynthetic process)|go:"GO:0042732"(D-xylose metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0048040"(UDP-glucuronate decarboxylase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070403"(NAD+ binding)|go:"GO:1902494"(catalytic complex)|interpro:IPR016040("NAD(P)-binding")|interpro:IPR021761|interpro:IPR036291|interpro:IPR044516|mint:Q8NBZ7|rcsb pdb:2B69|rcsb pdb:4GLL|rcsb pdb:4LK3|rcsb pdb:4M55	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:6+/mXlc000c7DIg4iVQCXs0ggFU9606	rigid:s5TELwwYlb3lxAgN1YhhNaqE8k4	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:A0JNW5	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-2850901|uniprotkb:Q8NDL1|uniprotkb:O75183|uniprotkb:Q9BTS5|uniprotkb:Q9H0F1|uniprotkb:A0PJE5|uniprotkb:Q96C30|ensembl:ENSP00000279907	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:uh1bl_human(display_long)|uniprotkb:KIAA0701(gene name synonym)|uniprotkb:UHRF1BP1L(gene name)|psi-mi:UHRF1BP1L(display_short)|uniprotkb:SHIP164(gene name synonym)|uniprotkb:Syntaxin-6 Habc-interacting protein of 164 kDa(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511475|imex:IM-28561-1455	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_001006948.1|refseq:NP_055869.1|ensembl:ENSG00000111647(gene)|ensembl:ENST00000279907(transcript)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0062069"(GARP complex binding)|interpro:IPR026728|interpro:IPR026854|mint:A0JNW5|reactome:R-HSA-9696270	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:237hjaOv2LiPUuNRvDZ3pPMym1Q9606	rigid:l0FFJ+jxJtyaS3m/LEXDSwE3sJ8	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q9NZI7	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-2795133|uniprotkb:Q68CT0|uniprotkb:Q86Y57|uniprotkb:Q9H8V0|uniprotkb:Q9UD76|uniprotkb:Q9UD78|ensembl:ENSP00000283628|ensembl:ENSP00000283629	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:ubip1_human(display_long)|uniprotkb:UBP1(gene name)|psi-mi:UBP1(display_short)|uniprotkb:LBP1(gene name synonym)|uniprotkb:Transcription factor LBP-1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511468|imex:IM-28561-1185	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_001121632.1|refseq:NP_001121633.1|refseq:NP_055332.3|ensembl:ENSG00000153560(gene)|ensembl:ENST00000283628(transcript)|ensembl:ENST00000283629(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR007604(CP2 transcription factor)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR037600|interpro:IPR041418|mint:Q9NZI7|go:"GO:0032897"(negative regulation of viral transcription)	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:aMcHSKF2w0CPIYmoyowV2a3I9Tk9606	rigid:runYTMt1ncbx8CxWVojOrz0VMMs	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q14157	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-347762|uniprotkb:Q5VU75|uniprotkb:Q5VU76|uniprotkb:Q9BTU3|uniprotkb:Q9UGL2|uniprotkb:Q9UGL3|uniprotkb:Q9UGL5|uniprotkb:B4E0U8|uniprotkb:Q9UGL4|ensembl:ENSP00000355343|ensembl:ENSP00000389445	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:ubp2l_human(display_long)|uniprotkb:UBAP2L(gene name)|psi-mi:UBAP2L(display_short)|uniprotkb:Protein NICE-4(gene name synonym)|uniprotkb:KIAA0144(gene name synonym)|uniprotkb:NICE4(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511459|imex:IM-28561-1183	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:XP_011508518.1|refseq:NP_001120792.1|refseq:NP_055662.3|refseq:NP_001274744.1|refseq:NP_001274745.1|refseq:XP_005245731.1|refseq:XP_016858467.1|refseq:XP_016858468.1|refseq:XP_016858475.1|refseq:XP_016858476.1|refseq:XP_016858478.1|refseq:XP_016858479.1|ensembl:ENSG00000143569(gene)|ensembl:ENST00000361546(transcript)|ensembl:ENST00000428931(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0031519"(PcG protein complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0061484"(hematopoietic stem cell homeostasis)|interpro:IPR009060(UBA-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR022166|mint:Q14157	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:4iKY4hJOHGSyOOt8zfPhkeyth6Q9606	rigid:YAKWGCveZE7+7sy3fpV/vQWrGHA	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:P07437	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-350864|uniprotkb:P05218|uniprotkb:Q8WUC1|uniprotkb:Q9CY33|ensembl:ENSP00000339001|ensembl:ENSP00000373058|ensembl:ENSP00000399155|ensembl:ENSP00000400663|ensembl:ENSP00000401317|ensembl:ENSP00000406811|ensembl:ENSP00000410071|ensembl:ENSP00000410829	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:tbb5_human(display_long)|uniprotkb:TUBB(gene name)|psi-mi:TUBB(display_short)|uniprotkb:Tubulin beta-5 chain(gene name synonym)|uniprotkb:TUBB5(gene name synonym)|uniprotkb:OK/SW-cl.56(orf name)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511452|imex:IM-28561-307	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_821133.1|refseq:NP_001280141.1|refseq:NP_001280142.1|refseq:NP_001280143.1|refseq:NP_001280144.1|refseq:NP_001280145.1|ensembl:ENSG00000183311(gene)|ensembl:ENSG00000196230(gene)|ensembl:ENSG00000224156(gene)|ensembl:ENSG00000227739(gene)|ensembl:ENSG00000229684(gene)|ensembl:ENSG00000232421(gene)|ensembl:ENSG00000232575(gene)|ensembl:ENSG00000235067(gene)|ensembl:ENST00000327892(transcript)|ensembl:ENST00000383564(transcript)|ensembl:ENST00000419792(transcript)|ensembl:ENST00000421473(transcript)|ensembl:ENST00000422650(transcript)|ensembl:ENST00000422674(transcript)|ensembl:ENST00000432462(transcript)|ensembl:ENST00000436628(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005874"(microtubule)|go:"GO:0007017"(microtubule-based process)|go:"GO:0009987"(cellular process)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0051225"(spindle assembly)|go:"GO:0051301"(cell division)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000217(Tubulin)|interpro:IPR002453(Beta tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR013838(Beta tubulin, autoregulation binding site)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:P07437|rcsb pdb:3QNZ|rcsb pdb:3QO0|rcsb pdb:5N5N|rcsb pdb:6I2I|rcsb pdb:6QUS|rcsb pdb:6QUY|rcsb pdb:6QVE|rcsb pdb:6QVJ|reactome:R-HSA-2565942|go:"GO:0050807"(regulation of synapse organization)|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-5620912|reactome:R-HSA-6798695|reactome:R-HSA-8854518|reactome:R-HSA-9679191|reactome:R-HSA-380320|dip:DIP-32772N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:B6pmb1dvCroZXGd/1Zazi+s72GA9606	rigid:oP2FPoCsYb730oAb5cJsAO3pRzM	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q6EMB2	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-725572|ensembl:ENSP00000298832|uniprotkb:Q9P1V5|uniprotkb:Q9UPZ4|uniprotkb:B9EGH8|uniprotkb:B9EGH9|uniprotkb:Q9BUB0|uniprotkb:Q9H0G4|uniprotkb:Q9H7W2	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:ttll5_human(display_long)|uniprotkb:Tubulin--tyrosine ligase-like protein 5(gene name synonym)|uniprotkb:SRC1 and TIF2-associated modulatory protein(gene name synonym)|uniprotkb:TTLL5(gene name)|psi-mi:TTLL5(display_short)|uniprotkb:STAMP(gene name synonym)|uniprotkb:KIAA0998(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511443|imex:IM-28561-545	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	ensembl:ENSG00000119685(gene)|ensembl:ENST00000298832(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0015631"(tubulin binding)|go:"GO:0018095"(protein polyglutamylation)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0070740"(tubulin-glutamic acid ligase activity)|interpro:IPR004344(Tubulin-tyrosine ligase)|mint:Q6EMB2|reactome:R-HSA-8955332|refseq:NP_055887.3|ensembl:ENST00000286650|ensembl:ENSP00000286650|ensembl:ENSP00000298832|ensembl:ENST00000556893|ensembl:ENSP00000452524	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:9+rHxJCDyOjHFpkYZCNxHWl6O5g9606	rigid:feg2Rw/wLD5zI+/nOwt+Lp6nX8k	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51116	uniprotkb:Q14155	intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113	intact:EBI-717515|uniprotkb:B1ALK6|uniprotkb:B1ALK8|uniprotkb:Q3LIA4|uniprotkb:Q5W9H0|uniprotkb:Q6P9G3|uniprotkb:Q6PII2|uniprotkb:Q86W63|uniprotkb:Q8N3M1|ensembl:ENSP00000364893	psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym)	psi-mi:arhg7_human(display_long)|uniprotkb:PAK-interacting exchange factor beta(gene name synonym)|uniprotkb:Beta-Pix(gene name synonym)|uniprotkb:COOL-1(gene name synonym)|uniprotkb:p85(gene name synonym)|uniprotkb:Nbla10314(orf name)|uniprotkb:ARHGEF7(gene name)|psi-mi:ARHGEF7(display_short)|uniprotkb:COOL1(gene name synonym)|uniprotkb:KIAA0142(gene name synonym)|uniprotkb:P85SPR(gene name synonym)|uniprotkb:PAK3BP(gene name synonym)|uniprotkb:PIXB(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511566|imex:IM-28561-1781	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z	refseq:NP_001307782.1|refseq:NP_663788.1|refseq:NP_001106983.1|refseq:NP_001106984.1|refseq:NP_001106985.1|refseq:NP_001307780.1|refseq:NP_001307783.1|refseq:NP_001317526.1|refseq:NP_001317527.1|ensembl:ENSG00000102606(gene)|ensembl:ENST00000375741(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0007030"(Golgi organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0005925"(focal adhesion)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043005"(neuron projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0098794"(postsynapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1904424"(regulation of GTP binding)|go:"GO:1905833"(negative regulation of microtubule nucleation)|go:"GO:2000394"(positive regulation of lamellipodium morphogenesis)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035789|interpro:IPR035899|interpro:IPR036028|interpro:IPR036872|mint:Q14155|rcsb pdb:1BY1|rcsb pdb:1ZSG|rcsb pdb:2L3G|rcsb pdb:5SXP|reactome:R-HSA-182971|reactome:R-HSA-193648|reactome:R-HSA-3928664|reactome:R-HSA-416482|reactome:R-HSA-8980692|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013406|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-9013424|reactome:R-HSA-9619229|dip:DIP-40794N|refseq:NP_003890.1|refseq:XP_016876313.1|refseq:XP_016876314.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606	rogid:0I59YglGXcYP7fFKIAWM6uCZY8Q9606	rigid:M79r9kldaOGOdAXQaAQD/9bRnB8	false	sufficient binding region:235-370	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51116	uniprotkb:Q08117	intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113	intact:EBI-717810|uniprotkb:Q12808|uniprotkb:Q96TG9|uniprotkb:Q9UDY9|uniprotkb:B2RBL0|uniprotkb:Q14CJ1|ensembl:ENSP00000317537	psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym)	psi-mi:tle5_human(display_long)|uniprotkb:TLE5(gene name)|psi-mi:TLE5(display_short)|uniprotkb:AES(gene name synonym)|uniprotkb:Amino-terminal enhancer of split(gene name synonym)|uniprotkb:GRG(gene name synonym)|uniprotkb:GRG5(gene name synonym)|uniprotkb:Gp130-associated protein GAM(gene name synonym)|uniprotkb:Grg-5(gene name synonym)|uniprotkb:Groucho-related protein 5(gene name synonym)|uniprotkb:Protein ESP1(gene name synonym)|uniprotkb:Protein GRG(gene name synonym)|uniprotkb:TLE family member 5, transcriptional modulator(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511559|imex:IM-28561-1779	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z	refseq:NP_001121.2|refseq:NP_945320.1|refseq:NP_945321.1|ensembl:ENSG00000104964(gene)|ensembl:ENST00000327141(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001501"(skeletal system development)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0007275"(multicellular organism development)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0040008"(regulation of growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0060761"(negative regulation of response to cytokine stimulus)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000210"(positive regulation of anoikis)|interpro:IPR005617(Groucho/TLE, N-terminal Q-rich region)|interpro:IPR009146(Groucho/transducin-like enhancer)|mint:Q08117|reactome:R-HSA-4641265|go:"GO:0032091"(negative regulation of protein binding)	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606	rogid:eveYX2Rj6Oz431E8nGcTk4bUNt89606	rigid:JnpZRZ0p6EwrDs3iAFrMr8oJ+CM	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:O75541	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-740865|ensembl:ENSP00000398089|ensembl:ENSP00000455648|uniprotkb:A6NK48|uniprotkb:B4DKK4|uniprotkb:D3DWS3	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:zn821_human(display_long)|uniprotkb:ZNF821(gene name)|psi-mi:ZNF821(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511552|imex:IM-28561-193	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	ensembl:ENSG00000102984(gene)|ensembl:ENST00000425432(transcript)|ensembl:ENST00000565601(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:O75541|refseq:NP_001188483.1|refseq:NP_060000.1|refseq:XP_011521513.1|refseq:NP_001188481.1|refseq:NP_001188482.1|refseq:NP_001188485.1|refseq:XP_006721296.1|refseq:XP_005256090.1|refseq:XP_016878898.1|refseq:XP_016878899.1|refseq:XP_016878900.1|refseq:XP_016878901.1|refseq:XP_016878903.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:LzrZF32gwK7sRhoOFlfhgbi7Eno9606	rigid:Rlwd/QLtyk3bhjobG1KWuDSPtug	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q2M1K9	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-950016|intact:EBI-28976649|ensembl:ENSP00000455426|uniprotkb:O94860|uniprotkb:Q9NZ13|uniprotkb:Q76N04	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:zn423_human(display_long)|uniprotkb:OAZ(gene name synonym)|uniprotkb:Olf1/EBF-associated zinc finger protein(gene name synonym)|uniprotkb:Smad- and Olf-interacting zinc finger protein(gene name synonym)|uniprotkb:ZNF423(gene name)|psi-mi:ZNF423(display_short)|uniprotkb:KIAA0760(gene name synonym)|uniprotkb:NPHP14(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511545|imex:IM-28561-655	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	go:"GO:0021930"(cerebellar granule cell precursor proliferation)|go:"GO:0021938"(smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:Q2M1K9|rcsb pdb:2MDG|ensembl:ENSG00000102935(gene)|ensembl:ENST00000561648(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007219"(Notch signaling pathway)|refseq:NP_055884.2|ensembl:ENSP00000455426|ensembl:ENST00000562520|ensembl:ENSP00000457664|ensembl:ENST00000562871|ensembl:ENSP00000457928|refseq:NP_001258549.1|refseq:XP_005255913.1|refseq:XP_016878567.1|refseq:XP_016878566.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:MvDTye6jC364XYE9jlFukJM+fAM9606	rigid:hSiNQzb+0AJZkuZNavsvKXpXFAU	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q9UDV6	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-1640204|uniprotkb:Q13396|uniprotkb:Q8N664|uniprotkb:B2RCF4|ensembl:ENSP00000338572	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:zn212_human(display_long)|uniprotkb:ZNF212(gene name)|psi-mi:ZNF212(display_short)|uniprotkb:ZNFC150(gene name synonym)|uniprotkb:Zinc finger protein C2H2-150(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511538|imex:IM-28561-415	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_036388.2|ensembl:ENSG00000170260(gene)|ensembl:ENST00000335870(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008270"(zinc ion binding)|go:"GO:0042802"(identical protein binding)|interpro:IPR001909(Krueppel-associated  box)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR022137|interpro:IPR036051|interpro:IPR036236|mint:Q9UDV6|reactome:R-HSA-212436	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:jZtScr5t/MR83+d1tdA9OiP4JCA9606	rigid:d4GYohionPTdquTnsSQpoYEqOgw	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51114	uniprotkb:Q9H869	intact:EBI-713291|uniprotkb:A8K9B8|uniprotkb:Q7Z450|uniprotkb:Q8N6R8|ensembl:ENSP00000350170	intact:EBI-946122|uniprotkb:Q5VYZ4|uniprotkb:Q5VYZ7|uniprotkb:Q7L4C3|uniprotkb:Q7L5E2|uniprotkb:Q8IXA6|uniprotkb:Q8TEW5|uniprotkb:Q8TF04|uniprotkb:Q96HB6|uniprotkb:Q9BQ64|uniprotkb:Q9NV84|uniprotkb:B0QZ54|uniprotkb:B4E0I0|uniprotkb:D3DV96|uniprotkb:D3DV98|uniprotkb:B4DMP2|uniprotkb:H7BY62|uniprotkb:Q5VYZ1|ensembl:ENSP00000295566	psi-mi:fxr1_human(display_long)|uniprotkb:FXR1(gene name)|psi-mi:FXR1(display_short)	psi-mi:yyap1_human(display_long)|uniprotkb:YY1AP1(gene name)|psi-mi:YY1AP1(display_short)|uniprotkb:HCCA2(gene name synonym)|uniprotkb:YY1AP(gene name synonym)|uniprotkb:Hepatocellular carcinoma susceptibility protein(gene name synonym)|uniprotkb:Hepatocellular carcinoma-associated protein 2(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511529|imex:IM-28561-1777	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013456.1|refseq:NP_001013457.1|refseq:NP_005078.2|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000114416(gene)|ensembl:ENST00000357559(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|go:"GO:0014069"(postsynaptic density)|rcsb pdb:2CPQ|rcsb pdb:3KUF|rcsb pdb:3O8V|reactome:R-HSA-6802952|mint:P51114|dip:DIP-40789N	refseq:NP_620829.1|refseq:NP_620830.1|refseq:NP_620832.1|refseq:NP_001185828.1|refseq:NP_001185829.1|refseq:NP_001185830.1|refseq:NP_001185831.1|refseq:NP_001185832.1|refseq:NP_001185833.1|refseq:NP_001185834.1|refseq:NP_001185835.1|refseq:NP_060723.2|ensembl:ENSG00000163374(gene)|ensembl:ENST00000295566(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030154"(cell differentiation)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR033274|mint:Q9H869	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pUW5/sakWOiRtZpigPhEMOPJBpk9606	rogid:4uUgCPNXV71ZGIgCOfpHO+1Ck/89606	rigid:is94l/0VCZbBJD8Tpi2lzPwLurY	false	sufficient binding region:215-363	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51116	uniprotkb:Q9H773	intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113	intact:EBI-723569|intact:EBI-1384169|ensembl:ENSP00000322524	psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym)	psi-mi:dctp1_human(display_long)|uniprotkb:DCTPP1(gene name)|psi-mi:DCTPP1(display_short)|uniprotkb:RS21C6(gene name synonym)|uniprotkb:CDA03(orf name)|uniprotkb:XTP3TPA(gene name synonym)|uniprotkb:Deoxycytidine-triphosphatase 1(gene name synonym)|uniprotkb:XTP3-transactivated gene A protein(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511707|imex:IM-28561-1461	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z	refseq:NP_077001.1|ensembl:ENST00000319285(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006253"(dCTP catabolic process)|go:"GO:0009143"(nucleoside triphosphate catabolic process)|go:"GO:0032556"(pyrimidine deoxyribonucleotide binding)|go:"GO:0042262"(DNA protection)|go:"GO:0042802"(identical protein binding)|go:"GO:0047429"(nucleoside-triphosphate diphosphatase activity)|go:"GO:0047840"(dCTP diphosphatase activity)|interpro:IPR025984|mint:Q9H773|reactome:R-HSA-499943|ensembl:ENSG00000179958(gene)	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606	rogid:4EfV2ZU2MgDiFXShthfualZnat09606	rigid:qNgpOEylB1xAQaq9mNJHVOEFERg	false	sufficient binding region:235-370	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51116	uniprotkb:P50570	intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113	intact:EBI-346547|uniprotkb:Q7Z5S3|uniprotkb:Q5I0Y0|uniprotkb:Q9UPH4|intact:EBI-3959204|uniprotkb:A8K1B6|uniprotkb:E7EV30|uniprotkb:K7ESI9|intact:EBI-5912046|uniprotkb:E9PEQ4|ensembl:ENSP00000347890	psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym)	psi-mi:dyn2_human(display_long)|uniprotkb:DNM2(gene name)|psi-mi:DNM2(display_short)|uniprotkb:DYN2(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511732|imex:IM-28561-317	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z	refseq:NP_004936.2|refseq:NP_001005360.1|refseq:NP_001005361.1|refseq:NP_001005362.1|refseq:NP_001177645.1|dip:DIP-31244N|reactome:R-HSA-203641|reactome:R-HSA-2132295|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-437239|reactome:R-HSA-8856828|reactome:R-HSA-9031628|reactome:R-HSA-196025|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031749"(D2 dopamine receptor binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033572"(transferrin transport)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044351"(macropinocytosis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050699"(WW domain binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0061024"(membrane organization)|go:"GO:0061025"(membrane fusion)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071245"(cellular response to carbon monoxide)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0098793"(presynapse)|go:"GO:0098844"(postsynaptic endocytic zone membrane)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902856"(negative regulation of non-motile cilium assembly)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903358"(regulation of Golgi organization)|go:"GO:1903408"("positive regulation of P-type sodium:potassium-exchanging transporter activity")|go:"GO:1903526"(negative regulation of membrane tubulation)|go:"GO:2000370"(positive regulation of clathrin-dependent endocytosis)|interpro:IPR000375(Dynamin central region)|interpro:IPR001401(Dynamin, GTPase region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR003130(Dynamin GTPase effector)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019762|interpro:IPR020850|interpro:IPR022812|interpro:IPR027188|interpro:IPR027417|interpro:IPR030381|mint:P50570|rcsb pdb:2YS1|reactome:R-HSA-166016|reactome:R-HSA-177504|reactome:R-HSA-190873|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008017"(microtubule binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016185"(synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|ensembl:ENSG00000079805(gene)|ensembl:ENST00000355667(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0001891"(phagocytic cup)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0003374"(dynamin family protein polymerization involved in mitochondrial fission)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005925"(focal adhesion)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0006897"(endocytosis)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606	rogid:BAUEy6Iju72PTot46Xhz75cQTQs9606	rigid:LHC1UKVIOdP+vz4wCGk3OyK6U6w	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51116	uniprotkb:Q13011	intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113	intact:EBI-711968|ensembl:ENSP00000221418|ensembl:ENSP00000489530|uniprotkb:Q8WVX0|uniprotkb:Q96EZ9|uniprotkb:A8K745	psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym)	psi-mi:ech1_human(display_long)|uniprotkb:ECH1(gene name)|psi-mi:ECH1(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511739|imex:IM-28561-975	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z	ensembl:ENSG00000104823(gene)|ensembl:ENSG00000282853(gene)|ensembl:ENST00000221418(transcript)|ensembl:ENST00000634245(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005777"(peroxisome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0016020"(membrane)|go:"GO:0051750"("delta(3,5)-delta(2,4)-dienoyl-CoA isomerase activity")|go:"GO:0070062"(extracellular exosome)|interpro:IPR001753(Crotonase, core)|interpro:IPR014748(Crontonase, C-terminal)|interpro:IPR018376|interpro:IPR029045|mint:Q13011|rcsb pdb:2VRE|reactome:R-HSA-9033241|refseq:NP_001389.2	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606	rogid:gh0bwdUu9tkSTHWuySCaTXIQGzI9606	rigid:UmPN/joURhD5zklyyBZCKfJ4Ihk	false	sufficient binding region:235-370	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51116	uniprotkb:P30084	intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113	intact:EBI-719602|uniprotkb:O00739|uniprotkb:Q5VWY1|uniprotkb:Q96H54|ensembl:ENSP00000357535	psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym)	psi-mi:echm_human(display_long)|uniprotkb:Short-chain enoyl-CoA hydratase(gene name synonym)|uniprotkb:Enoyl-CoA hydratase 1(gene name synonym)|uniprotkb:ECHS1(gene name)|psi-mi:ECHS1(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511748|imex:IM-28561-1463	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z	refseq:NP_004083.3|ensembl:ENSG00000127884(gene)|ensembl:ENST00000368547(transcript)|go:"GO:0004300"(enoyl-CoA hydratase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0009083"(branched-chain amino acid catabolic process)|go:"GO:0043956"(3-hydroxypropionyl-CoA dehydratase activity)|interpro:IPR001753(Crotonase, core)|interpro:IPR014748(Crontonase, C-terminal)|interpro:IPR018376|interpro:IPR029045|mint:P30084|rcsb pdb:2HW5|reactome:R-HSA-70895|reactome:R-HSA-77310|reactome:R-HSA-77346|reactome:R-HSA-77348|reactome:R-HSA-77350|reactome:R-HSA-77352|go:"GO:0120092"(crotonyl-CoA hydratase activity)	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606	rogid:zXekfKfyCbjaTVLTdDdAuMgiDco9606	rigid:CUUwGqhVQ1wIvlOKe9GEMx5EpX4	false	sufficient binding region:235-370	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51116	uniprotkb:Q86YR5	intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113	intact:EBI-741455|uniprotkb:A9Z1X4|uniprotkb:Q86SR5|uniprotkb:Q969T1|uniprotkb:Q9UFS8|uniprotkb:B1B0W3	psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym)	psi-mi:gpsm1_human(display_long)|uniprotkb:Activator of G-protein signaling 3(gene name synonym)|uniprotkb:GPSM1(gene name)|psi-mi:GPSM1(display_short)|uniprotkb:AGS3(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511814|imex:IM-28561-1675	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z	refseq:NP_001139111.1|refseq:NP_001186932.1|interpro:IPR003109(GoLoco)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|go:"GO:0000139"(Golgi membrane)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007399"(nervous system development)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0030154"(cell differentiation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:1905098"(negative regulation of guanyl-nucleotide exchange factor activity)|reactome:R-HSA-418594|refseq:NP_001139110.2|refseq:NP_056412.5|mint:Q86YR5|refseq:XP_016870088.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606	rogid:z9j02+hdH7Kc07ePs0AOgqvIfaA9606	rigid:8AOwAQsj1y4Bz2dl2+reh6BF2FM	false	sufficient binding region:235-370	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51116	uniprotkb:Q08379	intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113	intact:EBI-618309|intact:EBI-28970132|ensembl:ENSP00000478799|uniprotkb:Q6GRM9|uniprotkb:Q9BRB0|uniprotkb:Q9NYF9|uniprotkb:A0A0C4DGS5|intact:EBI-11522202	psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym)	psi-mi:goga2_human(display_long)|uniprotkb:GOLGA2(gene name)|psi-mi:GOLGA2(display_short)|uniprotkb:130 kDa cis-Golgi matrix protein(gene name synonym)|uniprotkb:GM130 autoantigen(gene name synonym)|uniprotkb:Golgin-95(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511807|imex:IM-28561-977	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z	ensembl:ENSG00000167110(gene)|ensembl:ENST00000611957(transcript)|go:"GO:0000137"(Golgi cis cisterna)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000922"(spindle pole)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005874"(microtubule)|go:"GO:0006486"(protein glycosylation)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007030"(Golgi organization)|go:"GO:0007098"(centrosome cycle)|go:"GO:0008017"(microtubule binding)|go:"GO:0008356"(asymmetric cell division)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0015031"(protein transport)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0060050"(positive regulation of protein glycosylation)|go:"GO:0061676"(importin-alpha family protein binding)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090161"(Golgi ribbon formation)|go:"GO:0090166"(Golgi disassembly)|go:"GO:0090306"(meiotic spindle assembly)|go:"GO:0090307"(mitotic spindle assembly)|interpro:IPR024858|interpro:IPR043937|interpro:IPR043976|mint:Q08379|rcsb pdb:4REY|rcsb pdb:6IW8|rcsb pdb:6IWA|rcsb pdb:6K06|reactome:R-HSA-162658|reactome:R-HSA-204005|reactome:R-HSA-6807878|reactome:R-HSA-8862803|refseq:NP_004477.3|ensembl:ENSP00000478799|dip:DIP-34271N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606	rogid:vIlRg4sJ2oBiARNnyerGMaVr5ZU9606	rigid:YsFxhSlEJ8wLFOUER2wyScLb+Ss	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51116	uniprotkb:P14136	intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113	intact:EBI-744302|uniprotkb:Q53H98|uniprotkb:Q5D055|uniprotkb:Q6ZQS3|uniprotkb:Q7Z5J6|uniprotkb:Q7Z5J7|uniprotkb:Q96KS4|uniprotkb:Q96P18|uniprotkb:Q9UFD0|uniprotkb:B2RD44|uniprotkb:D3DX59|intact:EBI-3909365|uniprotkb:E9PAX3|ensembl:ENSP00000466598|uniprotkb:A7REI1	psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym)	psi-mi:gfap_human(display_long)|uniprotkb:GFAP(gene name)|psi-mi:GFAP(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511798|imex:IM-28561-1465	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z	refseq:NP_001124491.1|refseq:NP_001229305.1|refseq:NP_002046.1|ensembl:ENSG00000131095(gene)|ensembl:ENST00000588735(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0009611"(response to wounding)|go:"GO:0010467"(gene expression)|go:"GO:0010625"(positive regulation of Schwann cell proliferation)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014002"(astrocyte development)|go:"GO:0019900"(kinase binding)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031102"(neuron projection regeneration)|go:"GO:0042802"(identical protein binding)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0044297"(cell body)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0051580"(regulation of neurotransmitter uptake)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0070779"(D-aspartate import across plasma membrane)|go:"GO:0097450"(astrocyte end-foot)|go:"GO:0098574"(cytoplasmic side of lysosomal membrane)|go:"GO:1904714"(regulation of chaperone-mediated autophagy)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|interpro:IPR027701|interpro:IPR039008|mint:P14136|rcsb pdb:6A9P|reactome:R-HSA-1251985|reactome:R-HSA-9613829	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606	rogid:Pz4JW0WjMjBYILTDSX9jUmMqWhg9606	rigid:WQJKy8JpuIff3x2JDX4g1RVtjgo	false	sufficient binding region:235-370	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51116	uniprotkb:P02794	intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113	intact:EBI-713259|uniprotkb:Q3KRA8|uniprotkb:Q3SWW1|ensembl:ENSP00000273550|ensembl:ENSP00000484477|uniprotkb:B3KNR5	psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym)	psi-mi:frih_human(display_long)|uniprotkb:Cell proliferation-inducing gene 15 protein(gene name synonym)|uniprotkb:FTH1(gene name)|psi-mi:FTH1(display_short)|uniprotkb:FTH(gene name synonym)|uniprotkb:FTHL6(gene name synonym)|uniprotkb:PIG15(orf name)|uniprotkb:OK/SW-cl.84(orf name)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511789|imex:IM-28561-557	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z	refseq:NP_002023.2|ensembl:ENSG00000167996(gene)|ensembl:ENST00000273550(transcript)|ensembl:ENST00000620041(transcript)|go:"GO:0004322"(ferroxidase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006826"(iron ion transport)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0006880"(intracellular sequestering of iron ion)|go:"GO:0006955"(immune response)|go:"GO:0008043"(intracellular ferritin complex)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008199"(ferric iron binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0044754"(autolysosome)|mint:P02794|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:1FHA|rcsb pdb:2CEI|rcsb pdb:2CHI|rcsb pdb:2CIH|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR001519(Ferritin, N-terminal)|interpro:IPR008331(Ferritin and Dps)|interpro:IPR009040(Ferritin-like)|interpro:IPR009078(Ferritin/ribonucleotide reductase-like)|interpro:IPR012347(Ferritin-related)|interpro:IPR014034(Ferritin, conserved site)|rcsb pdb:2CLU|rcsb pdb:2CN6|rcsb pdb:2CN7|rcsb pdb:2FHA|rcsb pdb:2IU2|rcsb pdb:2Z6M|rcsb pdb:3AJO|rcsb pdb:3AJP|rcsb pdb:3AJQ|rcsb pdb:3ERZ|rcsb pdb:3ES3|rcsb pdb:4DYX|rcsb pdb:4DYY|rcsb pdb:4DYZ|rcsb pdb:4Y08|rcsb pdb:4YKH|rcsb pdb:4ZJK|rcsb pdb:5CMQ|rcsb pdb:5CMR|rcsb pdb:5GN8|rcsb pdb:5GOU|rcsb pdb:5JKK|rcsb pdb:5JKL|rcsb pdb:5JKM|rcsb pdb:5N26|rcsb pdb:5N27|rcsb pdb:5UP7|rcsb pdb:5UP8|rcsb pdb:5UP9|rcsb pdb:5VTD|rcsb pdb:5XB1|rcsb pdb:5YI5|rcsb pdb:5ZND|rcsb pdb:6B8F|rcsb pdb:6B8G|rcsb pdb:4DZ0|rcsb pdb:6FTV|rcsb pdb:6GSR|rcsb pdb:6H5I|rcsb pdb:6H6T|rcsb pdb:6H6U|rcsb pdb:6IPC|rcsb pdb:6IPO|rcsb pdb:6IPP|rcsb pdb:6IPQ|rcsb pdb:6J4A|rcsb pdb:6J7G|rcsb pdb:6JOB|rcsb pdb:6JPS|rcsb pdb:6KE2|rcsb pdb:6KE4|rcsb pdb:4OYN|rcsb pdb:6M52|rcsb pdb:6M54|rcsb pdb:6WYF|rcsb pdb:6WYG|rcsb pdb:6WYH|rcsb pdb:6Z6U|rcsb pdb:6Z9E|rcsb pdb:6Z9F|rcsb pdb:7A6A|rcsb pdb:7A6B|rcsb pdb:7CK8|rcsb pdb:7CK9|rcsb pdb:7JGK|rcsb pdb:7JGL|rcsb pdb:7JGM|rcsb pdb:7JGN|rcsb pdb:7JGO|rcsb pdb:7JGP|rcsb pdb:7JGQ|rcsb pdb:7K26|rcsb pdb:7K3V|rcsb pdb:7K3W|reactome:R-HSA-3000480|reactome:R-HSA-432722|reactome:R-HSA-6798695|reactome:R-HSA-917937|dip:DIP-38301N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606	rogid:TchHgRpv+inA8BQ5i0OHaa267tQ9606	rigid:t5z4kw4+2ZQrYMI0lPyOIiYMml8	false	sufficient binding region:235-370	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51116	uniprotkb:Q01844	intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113	intact:EBI-739737|uniprotkb:Q92635|uniprotkb:Q96FE8|uniprotkb:Q96MX4|uniprotkb:Q9BWA2|uniprotkb:Q5THL0|intact:EBI-28987207|ensembl:ENSP00000381031|intact:EBI-10985407|uniprotkb:B0QYK1|uniprotkb:Q96MN4	psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym)	psi-mi:ews_human(display_long)|uniprotkb:EWSR1(gene name)|psi-mi:EWSR1(display_short)|uniprotkb:EWS(gene name synonym)|uniprotkb:EWS oncogene(gene name synonym)|uniprotkb:Ewing sarcoma breakpoint region 1 protein(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511782|imex:IM-28561-753	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z	refseq:NP_001156757.1|refseq:NP_005234.1|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033109|interpro:IPR034869|interpro:IPR034870|interpro:IPR035979|interpro:IPR036443|mint:Q01844|rcsb pdb:2CPE|interpro:IPR001876(Zinc finger, RanBP2-type)|ensembl:ENSG00000182944(gene)|ensembl:ENST00000397938(transcript)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|refseq:NP_001156759.1|refseq:NP_053733.2|refseq:NP_001156758.1|ensembl:ENST00000332035|ensembl:ENSP00000331699|ensembl:ENST00000333395|ensembl:ENSP00000327456|ensembl:ENSP00000381031|ensembl:ENST00000406548|ensembl:ENSP00000385726|ensembl:ENST00000414183|ensembl:ENSP00000400142|dip:DIP-34449N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606	rogid:7PxoTjcmcdUA3clzf0eW+iCFaS49606	rigid:JpshEg2nZFneviZzug6aEGFerYg	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51116	uniprotkb:P52272	intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113	intact:EBI-486809|uniprotkb:Q9Y492|uniprotkb:Q15584|uniprotkb:Q8WZ44|uniprotkb:Q96H56|uniprotkb:Q9BWL9|intact:EBI-28985795|ensembl:ENSP00000325376	psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym)	psi-mi:hnrpm_human(display_long)|uniprotkb:HNRNPM(gene name)|psi-mi:HNRNPM(display_short)|uniprotkb:HNRPM(gene name synonym)|uniprotkb:NAGR1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511848|imex:IM-28561-319	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z	refseq:NP_005959.2|refseq:NP_112480.2|ensembl:ENSG00000099783(gene)|ensembl:ENST00000325495(transcript)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0016020"(membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0042382"(paraspeckles)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0071014"(post-mRNA release spliceosomal complex)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000815"(regulation of mRNA stability involved in response to oxidative stress)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR024666|interpro:IPR024667|interpro:IPR034990|interpro:IPR035979|mint:P52272|rcsb pdb:2DGV|rcsb pdb:2DH9|rcsb pdb:2DO0|rcsb pdb:2OT8|reactome:R-HSA-6803529|reactome:R-HSA-72163|reactome:R-HSA-72203|dip:DIP-29336N|ensembl:ENSP00000325376|ensembl:ENST00000348943|ensembl:ENSP00000325732	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606	rogid:5FnCgrz0xltEkgw3yh70KP2jz5g9606	rigid:8ZylrG8c/w1ORR6y9X91+aWP23A	false	sufficient binding region:235-370	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51116	uniprotkb:Q9UHF1	intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113	intact:EBI-949532|ensembl:ENSP00000307843|ensembl:ENSP00000360763|ensembl:ENSP00000360764|ensembl:ENSP00000385639|uniprotkb:Q5M7Y5|uniprotkb:Q5VUD5|uniprotkb:Q96EG0|uniprotkb:B3KRP0|uniprotkb:M9VTX9	psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym)	psi-mi:egfl7_human(display_long)|uniprotkb:Multiple epidermal growth factor-like domains protein 7(gene name synonym)|uniprotkb:Zneu1(gene name synonym)|uniprotkb:Vascular endothelial statin(gene name synonym)|uniprotkb:NOTCH4-like protein(gene name synonym)|uniprotkb:EGFL7(gene name)|psi-mi:EGFL7(display_short)|uniprotkb:MEGF7(gene name synonym)|uniprotkb:UNQ187/PRO1449(orf name)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511766|imex:IM-28561-555	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z	ensembl:ENSG00000172889(gene)|ensembl:ENST00000308874(transcript)|ensembl:ENST00000371698(transcript)|ensembl:ENST00000371699(transcript)|ensembl:ENST00000406555(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001568"(blood vessel development)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0007155"(cell adhesion)|go:"GO:0009986"(cell surface)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0048856"(anatomical structure development)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011489(EMI)|interpro:IPR013111(EGF, extracellular)|interpro:IPR018097|mint:Q9UHF1|go:"GO:0005576"(extracellular region)|refseq:NP_057299.1|refseq:NP_958854.1|refseq:XP_011517066.1|refseq:XP_011517067.1|refseq:XP_011517068.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606	rogid:HzaJXQm4JE8bXXE+/ugmqGjpjZA9606	rigid:ocMm0fknMJgRNp0ss3RX7UQyG7g	false	sufficient binding region:235-370	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51116	uniprotkb:Q6P2E9	intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113	intact:EBI-1006038|uniprotkb:Q13025|uniprotkb:Q13826|uniprotkb:Q6ZR12|uniprotkb:Q7Z6H7|uniprotkb:A6NGM1|uniprotkb:A8K4T4|ensembl:ENSP00000351811	psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym)	psi-mi:edc4_human(display_long)|uniprotkb:Human enhancer of decapping large subunit(gene name synonym)|uniprotkb:Autoantigen Ge-1(gene name synonym)|uniprotkb:Autoantigen RCD-8(gene name synonym)|uniprotkb:EDC4(gene name)|psi-mi:EDC4(display_short)|uniprotkb:HEDLS(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511757|imex:IM-28561-117	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z	ensembl:ENSG00000038358(gene)|interpro:IPR036322|mint:Q6P2E9|reactome:R-HSA-430039|ensembl:ENST00000358933(transcript)|go:"GO:0000932"(P-body)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|go:"GO:0031087"(deadenylation-independent decapping of nuclear-transcribed mRNA)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR032401|refseq:NP_055144.3|dip:DIP-31192N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606	rogid:V5obZo71xmJbNRv5fc+o7wNdb+Y9606	rigid:26qjjaTylGAVr9/atXNlSHiJ7vo	false	sufficient binding region:235-370	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P81274	uniprotkb:P51116	intact:EBI-618655|uniprotkb:Q5T1N8|ensembl:ENSP00000264126|ensembl:ENSP00000385510|ensembl:ENSP00000392138|ensembl:ENSP00000496104|ensembl:ENSP00000496756|ensembl:ENSP00000502178|uniprotkb:Q8N0Z5|uniprotkb:Q6IBL7	intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113	psi-mi:gpsm2_human(display_long)|uniprotkb:GPSM2(gene name)|psi-mi:GPSM2(display_short)|uniprotkb:LGN(gene name synonym)|uniprotkb:Mosaic protein LGN(gene name synonym)	psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511823|imex:IM-28561-1677	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000121957(gene)|ensembl:ENST00000264126(transcript)|ensembl:ENST00000406462(transcript)|ensembl:ENST00000446797(transcript)|ensembl:ENST00000642355(transcript)|ensembl:ENST00000645164(transcript)|ensembl:ENST00000676184(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000166"(nucleotide binding)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031291"(Ran protein signal transduction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0051301"(cell division)|go:"GO:0051661"(maintenance of centrosome location)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0070840"(dynein complex binding)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0097575"(lateral cell cortex)|go:"GO:0099738"(cell cortex region)|go:"GO:1904778"(positive regulation of protein localization to cell cortex)|go:"GO:1905832"(positive regulation of spindle assembly)|interpro:IPR003109(GoLoco)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|mint:P81274|rcsb pdb:3SF4|rcsb pdb:4WND|rcsb pdb:4WNE|rcsb pdb:4WNF|rcsb pdb:4WNG|rcsb pdb:5A6C|rcsb pdb:6HC2|reactome:R-HSA-418594|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0007052"(mitotic spindle organization)|refseq:NP_037428.3|refseq:NP_001307967.1|refseq:NP_001307968.1|refseq:XP_011539603.1|refseq:XP_011539604.1|refseq:XP_016856586.1|refseq:XP_016856587.1|dip:DIP-399N	interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:qQOgAYWYhHlMg4d8HsqCxcNqnNg9606	rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606	rigid:x4ueqEA7/e5FvOk3piDY/+zjz5g	false	-	sufficient binding region:235-370	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51116	uniprotkb:Q9Y3R0	intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113	intact:EBI-5349621|uniprotkb:C9JT59|uniprotkb:Q1RLM0|ensembl:ENSP00000352780	psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym)	psi-mi:grip1_human(display_long)|uniprotkb:GRIP1(gene name)|psi-mi:GRIP1(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511832|imex:IM-28561-119	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z	refseq:XP_011536395.1|refseq:NP_001171545.1|refseq:NP_066973.2|ensembl:ENSG00000155974(gene)|ensembl:ENST00000359742(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016358"(dendrite development)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030425"(dendrite)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0045121"(membrane raft)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|go:"GO:0150012"(positive regulation of neuron projection arborization)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR030026|interpro:IPR036034|interpro:IPR041489|interpro:IPR043545|mint:Q9Y3R0|rcsb pdb:2JIL|reactome:R-HSA-416993	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606	rogid:BBMxSfND5Mr47/EoX8y0RmCQjCc9606	rigid:K2IwTKjPNOij2qNxS7xt+EHe1rs	false	sufficient binding region:235-370	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51116	uniprotkb:P15822	intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113	intact:EBI-722264|uniprotkb:Q14122|uniprotkb:Q5VW60|uniprotkb:B2RTU3|uniprotkb:Q5MPB1|ensembl:ENSP00000368698	psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym)	psi-mi:zep1_human(display_long)|uniprotkb:Human immunodeficiency virus type I enhancer-binding protein 1(gene name synonym)|uniprotkb:Major histocompatibility complex-binding protein 1(gene name synonym)|uniprotkb:Positive regulatory domain II-binding factor 1(gene name synonym)|uniprotkb:HIVEP1(gene name)|psi-mi:HIVEP1(display_short)|uniprotkb:ZNF40(gene name synonym)|uniprotkb:Gate keeper of apoptosis-activating protein(gene name synonym)|uniprotkb:Cirhin interaction protein(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511841|imex:IM-28561-755	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z	refseq:NP_002105.3|ensembl:ENSG00000095951(gene)|ensembl:ENST00000379388(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016604"(nuclear body)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR034729|interpro:IPR036236|mint:P15822|rcsb pdb:1BBO|rcsb pdb:3ZNF|rcsb pdb:4ZNF	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606	rogid:rugwzqsTO0X8mJ5Zy3msTqc6dr09606	rigid:X7FM7oG/P2wUIi/AfysZfvziewg	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51116	uniprotkb:Q9UI08	intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113	intact:EBI-346653|uniprotkb:O95884|uniprotkb:Q7Z522|uniprotkb:Q8TBV1|uniprotkb:Q9UF25|uniprotkb:A8K105|uniprotkb:Q9UIC2|uniprotkb:B7Z3I5|ensembl:ENSP00000384720	psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym)	psi-mi:evl_human(display_long)|uniprotkb:EVL(gene name)|psi-mi:EVL(display_short)|uniprotkb:RNB6(gene name synonym)|uniprotkb:Ena/vasodilator-stimulated phosphoprotein-like(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511775|imex:IM-28561-1195	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z	refseq:NP_057421.1|refseq:NP_001317150.1|ensembl:ENSG00000196405(gene)|ensembl:ENST00000402714(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010633"(negative regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0045010"(actin nucleation)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:1900028"(negative regulation of ruffle assembly)|interpro:IPR000697(EVH1)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014885(VASP tetramerisation)|interpro:IPR017354(Vasodilator-stimulated phosphoprotein)|interpro:IPR034319|interpro:IPR038023|mint:Q9UI08|reactome:R-HSA-202433|reactome:R-HSA-376176|reactome:R-HSA-5663220	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606	rogid:ZYA6pfvqC68sm/0egUg4hBif/Pc9606	rigid:bkWS1wIpfGG2eho9vyEh7mNTKk0	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51116	uniprotkb:P35580	intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113	intact:EBI-351758|intact:EBI-7850240|intact:MINT-8330016|uniprotkb:B2RWP9|uniprotkb:D3DTS1|uniprotkb:Q9BWG0|uniprotkb:Q12989|uniprotkb:Q16087|uniprotkb:Q149N3|ensembl:ENSP00000269243|uniprotkb:Q149N4|uniprotkb:Q6PK16|uniprotkb:F8VTL3|uniprotkb:Q4LE45	psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym)	psi-mi:myh10_human(display_long)|uniprotkb:MYH10(gene name)|psi-mi:MYH10(display_short)|uniprotkb:Myosin heavy chain 10(gene name synonym)|uniprotkb:Myosin heavy chain, non-muscle IIb(gene name synonym)|uniprotkb:Non-muscle myosin heavy chain IIb(gene name synonym)|uniprotkb:Cellular myosin heavy chain, type B(gene name synonym)|uniprotkb:Non-muscle myosin heavy chain B(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511990|imex:IM-28561-1681	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z	refseq:NP_001243024.1|refseq:NP_001242941.1|refseq:NP_005955.3|ensembl:ENSG00000133026(gene)|ensembl:ENST00000269243(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001725"(stress fiber)|go:"GO:0003779"(actin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005938"(cell cortex)|go:"GO:0007155"(cell adhesion)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016459"(myosin complex)|go:"GO:0016460"(myosin II complex)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030496"(midbody)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0032154"(cleavage furrow)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0042641"(actomyosin)|go:"GO:0043531"(ADP binding)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051015"(actin filament binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097513"(myosin II filament)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR002928(Myosin tail)|interpro:IPR004009(Myosin, N-terminal, SH3-like)|interpro:IPR008989(Myosin S1 fragment, N-terminal)|interpro:IPR027417|interpro:IPR036961|mint:P35580|rcsb pdb:4PD3|reactome:R-HSA-3928663|reactome:R-HSA-416572|reactome:R-HSA-5625740|reactome:R-HSA-5625900|reactome:R-HSA-5627117|reactome:R-HSA-5627123|refseq:XP_016880169.1|refseq:XP_016880170.1|refseq:XP_016880171.1|dip:DIP-31110N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606	rogid:iSHfJZbrWg1L+vSpu1n7RmTTNN49606	rigid:9MeNeiqmOrYl9QqMIqHRC81kJbs	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51116	uniprotkb:Q14764	intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113	intact:EBI-2816254|uniprotkb:Q9BPW6|uniprotkb:Q9BQT1|uniprotkb:Q96BG4|uniprotkb:Q9UBD1|intact:EBI-28971732|ensembl:ENSP00000349977|ensembl:ENSP00000378760	psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym)	psi-mi:mvp_human(display_long)|uniprotkb:MVP(gene name)|psi-mi:MVP(display_short)|uniprotkb:LRP(gene name synonym)|uniprotkb:Lung resistance-related protein(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511983|imex:IM-28561-1679	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z	ensembl:ENSP00000349977|ensembl:ENSP00000378760|refseq:NP_001280133.1|refseq:NP_001280134.1|refseq:NP_005106.2|refseq:NP_059447.2|ensembl:ENSG00000013364(gene)|ensembl:ENST00000357402(transcript)|ensembl:ENST00000395353(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005643"(nuclear pore)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051028"(mRNA transport)|go:"GO:0061099"(negative regulation of protein tyrosine kinase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002499(Major vault protein, N-terminal)|interpro:IPR021870|interpro:IPR036013|interpro:IPR039059|interpro:IPR040989|interpro:IPR041134|interpro:IPR041136|interpro:IPR041139|interpro:IPR043023|interpro:IPR043179|mint:Q14764|rcsb pdb:1Y7X|reactome:R-HSA-6798695	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606	rogid:z/Hc6TeTzO5QSpZ8AUXiI2ox4eg9606	rigid:TWXw9VuvG3ScYYRazfoROdrpwww	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51116	uniprotkb:Q00013	intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113	intact:EBI-711788|uniprotkb:B4DZV5|uniprotkb:Q5J7V5|uniprotkb:G3XAI1|uniprotkb:Q2TSB6|ensembl:ENSP00000358547	psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym)	psi-mi:em55_human(display_long)|uniprotkb:Membrane protein, palmitoylated 1(gene name synonym)|uniprotkb:MPP1(gene name)|psi-mi:MPP1(display_short)|uniprotkb:EMP55(gene name synonym)|uniprotkb:DXS552E(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511974|imex:IM-28561-1475	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z	refseq:NP_001159932.1|refseq:NP_001159933.1|refseq:NP_001159934.1|refseq:NP_002427.1|ensembl:ENSG00000130830(gene)|ensembl:ENST00000369534(transcript)|go:"GO:0004385"(guanylate kinase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0032420"(stereocilium)|go:"GO:0034451"(centriolar satellite)|go:"GO:0090022"(regulation of neutrophil chemotaxis)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR020590|interpro:IPR027417|interpro:IPR035475|interpro:IPR036028|interpro:IPR036034|mint:Q00013|rcsb pdb:2EJY|rcsb pdb:2EV8|rcsb pdb:3NEY|reactome:R-HSA-9662361	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606	rogid:b9QmIlmQ5SZHnOQfGSezmcvaDls9606	rigid:070hXc7+oc+t3WkYtEQTwBTKS3c	false	sufficient binding region:235-370	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51116	uniprotkb:O60336	intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113	intact:EBI-947402|uniprotkb:A8K8P9|uniprotkb:Q14CB5|uniprotkb:Q14CD8|uniprotkb:Q5W9G9|uniprotkb:Q49AJ8|uniprotkb:A6NM93|ensembl:ENSP00000393099	psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym)	psi-mi:mabp1_human(display_long)|uniprotkb:MAPKBP1(gene name)|psi-mi:MAPKBP1(display_short)|uniprotkb:JNKBP1(gene name synonym)|uniprotkb:KIAA0596(gene name synonym)|uniprotkb:JNK-binding protein 1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511965|imex:IM-28561-321	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z	refseq:NP_001122080.1|refseq:NP_055809.2|refseq:NP_001252540.1|ensembl:ENSG00000137802(gene)|ensembl:ENST00000456763(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:1900425"(negative regulation of defense response to bacterium)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|mint:O60336	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606	rogid:7o2Pxm1NiSuV7txoMpcismKbn/s9606	rigid:5COTrcA7Rbc2lHASpnyk413+VQ4	false	sufficient binding region:235-370	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51116	uniprotkb:Q9Y5V3	intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113	intact:EBI-716006|uniprotkb:Q5VSH6|uniprotkb:Q8IZ84|uniprotkb:Q8WY92|uniprotkb:Q9H352|uniprotkb:Q9HBT4|uniprotkb:Q9UF36|ensembl:ENSP00000325333|ensembl:ENSP00000364874|ensembl:ENSP00000364927	psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym)	psi-mi:magd1_human(display_long)|uniprotkb:MAGE-D1 antigen(gene name synonym)|uniprotkb:Neurotrophin receptor-interacting MAGE homolog(gene name synonym)|uniprotkb:MAGE tumor antigen CCF(gene name synonym)|uniprotkb:MAGED1(gene name)|psi-mi:MAGED1(display_short)|uniprotkb:NRAGE(gene name synonym)|uniprotkb:PRO2292(orf name)|uniprotkb:PP2250(orf name)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511956|imex:IM-28561-1473	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z	refseq:NP_001005332.1|refseq:NP_001005333.1|refseq:NP_008917.3|ensembl:ENSP00000325333|ensembl:ENST00000375695|ensembl:ENSP00000364847|ensembl:ENSP00000364874|ensembl:ENSP00000364927|refseq:XP_011529137.1|refseq:XP_016885467.1|refseq:XP_016885468.1|refseq:XP_016885469.1|ensembl:ENSG00000179222(gene)|ensembl:ENST00000326587(transcript)|ensembl:ENST00000375722(transcript)|ensembl:ENST00000375772(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR002190(MAGE protein)|interpro:IPR030083|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|mint:Q9Y5V3|reactome:R-HSA-193648|reactome:R-HSA-418889	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606	rogid:UTg0r4zGMXfTZqBN4SFmgu6IukI9606	rigid:0RAjD2m5pefwtVnEMcXE+oqEauo	false	sufficient binding region:235-370	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51116	uniprotkb:Q96JM7	intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113	intact:EBI-2686809|uniprotkb:Q4VXE1|uniprotkb:Q6P9B5|uniprotkb:Q5VUM9|ensembl:ENSP00000354526|ensembl:ENSP00000357118	psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym)	psi-mi:lmbl3_human(display_long)|uniprotkb:KIAA1798(gene name synonym)|uniprotkb:MBT1(gene name synonym)|uniprotkb:MBT-1(gene name synonym)|uniprotkb:L3MBTL3(gene name)|psi-mi:L3MBTL3(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511949|imex:IM-28561-759	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z	refseq:XP_011534481.1|refseq:XP_011534482.1|refseq:XP_011534483.1|refseq:XP_011534485.1|refseq:XP_011534486.1|refseq:NP_001007103.1|refseq:NP_115814.1|refseq:NP_001333480.1|refseq:NP_001333479.1|refseq:XP_005267218.1|refseq:XP_006715641.1|ensembl:ENSG00000198945(gene)|ensembl:ENST00000361794(transcript)|ensembl:ENST00000368136(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006325"(chromatin organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030851"(granulocyte differentiation)|go:"GO:0042393"(histone binding)|go:"GO:0043249"(erythrocyte maturation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002515(Zinc finger, C2HC-type)|interpro:IPR004092(Mbt repeat)|interpro:IPR013761(Sterile alpha motif-type)|mint:Q96JM7|rcsb pdb:1WJQ|rcsb pdb:1WJS|rcsb pdb:3UT1|rcsb pdb:4FL6|rcsb pdb:4L59|go:"GO:0042802"(identical protein binding)|dip:DIP-42798N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606	rogid:FYLlz+1Skg07Aw8gqXDVDFevaEg9606	rigid:98rWU1fTeHABE7GQIE8ouPm7Dwg	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51116	uniprotkb:Q9Y468	intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113	intact:EBI-1265089|uniprotkb:B4DRC9|uniprotkb:E1P5W7|uniprotkb:Q5H8Y9|uniprotkb:Q5H8Y8|uniprotkb:Q8IUV7|uniprotkb:Q9H1E6|uniprotkb:Q9H1G5|uniprotkb:Q9UG06|uniprotkb:Q9UJB9|uniprotkb:Q9Y4C9|ensembl:ENSP00000402107	psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym)	psi-mi:lmbl1_human(display_long)|uniprotkb:L3MBTL1(gene name)|psi-mi:L3MBTL1(display_short)|uniprotkb:KIAA0681(gene name synonym)|uniprotkb:L3MBT(gene name synonym)|uniprotkb:L3MBTL1(gene name synonym)|uniprotkb:"L(3)mbt protein homolog"(gene name synonym)|uniprotkb:L3MBTL(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511942|imex:IM-28561-1471	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z	refseq:NP_056293.4|refseq:NP_115479.4|dip:DIP-29628N|ensembl:ENSG00000185513(gene)|ensembl:ENST00000427442(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000793"(condensed chromosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006325"(chromatin organization)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030097"(hemopoiesis)|go:"GO:0031491"(nucleosome binding)|go:"GO:0031493"(obsolete nucleosomal histone binding)|go:"GO:0032093"(SAM domain binding)|go:"GO:0035064"(methylated histone binding)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045652"(regulation of megakaryocyte differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR002515(Zinc finger, C2HC-type)|interpro:IPR004092(Mbt repeat)|interpro:IPR036060|mint:Q9Y468|rcsb pdb:1OYX|rcsb pdb:1OZ2|rcsb pdb:1OZ3|rcsb pdb:2PQW|rcsb pdb:2RHI|rcsb pdb:2RHU|rcsb pdb:2RHX|rcsb pdb:2RHY|rcsb pdb:2RHZ|rcsb pdb:2RI2|rcsb pdb:2RI3|rcsb pdb:2RI5|rcsb pdb:2RJC|rcsb pdb:2RJD|rcsb pdb:2RJE|rcsb pdb:2RJF|rcsb pdb:3OQ5|rcsb pdb:3P8H|rcsb pdb:3UWN|rcsb pdb:6BYB|reactome:R-HSA-6804760|go:"GO:0003682"(chromatin binding)	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606	rogid:hLkGs3Aq9xKCwsdSghESzw3LYcQ9606	rigid:iXrl1MmorX8D4CHCvGS64uUCGjw	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51116	uniprotkb:P05783	intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113	intact:EBI-297888|uniprotkb:Q53G38|uniprotkb:Q5U0N8|uniprotkb:Q9BW26|ensembl:ENSP00000373487|ensembl:ENSP00000373489	psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym)	psi-mi:k1c18_human(display_long)|uniprotkb:KRT18(gene name)|psi-mi:KRT18(display_short)|uniprotkb:CYK18(gene name synonym)|uniprotkb:Keratin-18(gene name synonym)|uniprotkb:PIG46(orf name)|uniprotkb:Cytokeratin-18(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 46 protein(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511933|imex:IM-28561-561	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z	go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0005912"(adherens junction)|go:"GO:0007049"(cell cycle)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009750"(response to fructose)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034451"(centriolar satellite)|go:"GO:0043000"(Golgi to plasma membrane CFTR protein transport)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045095"(keratin filament)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070365"(hepatocyte differentiation)|go:"GO:0072497"(mesenchymal stem cell differentiation)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:1902488"(cholangiocyte apoptotic process)|interpro:IPR002957(Keratin, type I)|interpro:IPR018039|interpro:IPR027695|interpro:IPR039008|mint:P05783|reactome:R-HSA-6805567|reactome:R-HSA-6809371|ensembl:ENSG00000111057(gene)|ensembl:ENST00000388835(transcript)|ensembl:ENST00000388837(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|refseq:NP_000215.1|refseq:NP_954657.1|dip:DIP-633N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606	rogid:6rtLZxuG0CSGcsCHEmkRKFVDeyo9606	rigid:7woZpt2kmrYnfCzSjVlus0IHlc8	false	sufficient binding region:235-370	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51116	uniprotkb:Q2M1P5	intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113	intact:EBI-2512228|ensembl:ENSP00000377934|uniprotkb:Q3SXY0|uniprotkb:Q6UXE9|uniprotkb:Q8IW72	psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym)	psi-mi:kif7_human(display_long)|uniprotkb:KIF7(gene name)|psi-mi:KIF7(display_short)|uniprotkb:UNQ340/PRO539(orf name)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511924|imex:IM-28561-1197	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z	ensembl:ENSG00000166813(gene)|ensembl:ENST00000394412(transcript)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0005929"(cilium)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0008017"(microtubule binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0097542"(ciliary tip)|go:"GO:1990939"|interpro:IPR001752(Kinesin, motor region)|interpro:IPR019821|interpro:IPR027417|interpro:IPR036961|mint:Q2M1P5|rcsb pdb:2XT3|rcsb pdb:4A14|rcsb pdb:6MLQ|rcsb pdb:6MLR|reactome:R-HSA-5610787|reactome:R-HSA-5632684|refseq:NP_940927.2	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606	rogid:yEZWFId7u3KkCdclCbZNeAZS1B49606	rigid:WX2jz0UE1Km2o1BX+5RmDk3NNCQ	false	sufficient binding region:235-370	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51116	uniprotkb:Q8N163	intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113	intact:EBI-355410|uniprotkb:A6NL03|uniprotkb:Q6P0Q9|uniprotkb:Q8N3G7|uniprotkb:Q8N8M1|uniprotkb:Q8TF34|uniprotkb:Q9H9Q9|uniprotkb:Q9HD12|uniprotkb:Q9NT55|ensembl:ENSP00000310670|ensembl:ENSP00000373930|uniprotkb:B2RB79|uniprotkb:D3DSR6	psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym)	psi-mi:ccar2_human(display_long)|uniprotkb:CCAR2(gene name)|psi-mi:CCAR2(display_short)|uniprotkb:Cell division cycle and apoptosis regulator protein 2(gene name synonym)|uniprotkb:DBC1(gene name synonym)|uniprotkb:DBIRD complex subunit KIAA1967(gene name synonym)|uniprotkb:Deleted in breast cancer gene 1 protein(gene name synonym)|uniprotkb:KIAA1967(gene name synonym)|uniprotkb:p30 DBC(gene name synonym)|uniprotkb:NET35(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511915|imex:IM-28561-1469	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z	refseq:NP_066997.3|ensembl:ENSG00000158941(gene)|ensembl:ENST00000308511(transcript)|ensembl:ENST00000389279(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005819"(spindle)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0008380"(RNA splicing)|go:"GO:0009411"(response to UV)|go:"GO:0016055"(Wnt signaling pathway)|interpro:IPR028811|mint:Q8N163|reactome:R-HSA-3371453|go:"GO:0019899"(enzyme binding)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032784"(regulation of DNA-templated transcription, elongation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0044609"(DBIRD complex)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048511"(rhythmic process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090311"(regulation of protein deacetylation)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:2000003"(positive regulation of DNA damage checkpoint)|interpro:IPR011992(EF-Hand type)|interpro:IPR025223|interpro:IPR025224|interpro:IPR025954|dip:DIP-38122N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606	rogid:GL+fD8W0kadrYrBkuMqoKgbbITU9606	rigid:kfRBS/+GiqzFCTT7O/PBkHmp+4c	false	sufficient binding region:235-370	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51116	uniprotkb:Q07666	intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113	intact:EBI-1364|uniprotkb:Q6PJX7|uniprotkb:Q8NB97|uniprotkb:Q99760|uniprotkb:D3DPP3|ensembl:ENSP00000313829	psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym)	psi-mi:khdr1_human(display_long)|uniprotkb:SAM68(gene name synonym)|uniprotkb:Src-associated in mitosis 68 kDa protein(gene name synonym)|uniprotkb:KHDRBS1(gene name)|psi-mi:KHDRBS1(display_short)|uniprotkb:p21 Ras GTPase-activating protein-associated p62(gene name synonym)|uniprotkb:GAP-associated tyrosine phosphoprotein p62(gene name synonym)|uniprotkb:p68(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511908|imex:IM-28561-981	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z	refseq:NP_006550.1|refseq:NP_001258807.1|dip:DIP-29007N|ensembl:ENSG00000121774(gene)|ensembl:ENST00000327300(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008143"("poly(A) binding")|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046831"(regulation of RNA export from nucleus)|go:"GO:0046833"(positive regulation of RNA export from nucleus)|go:"GO:0048024"(regulation of mRNA splicing, via spliceosome)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0070618"(Grb2-Sos complex)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032335|interpro:IPR032571|interpro:IPR036612|mint:Q07666|rcsb pdb:2XA6|rcsb pdb:3QHE|reactome:R-HSA-8849468	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606	rogid:po7jC4Nxu+Aoz6T8K6VRWHp6MKQ9606	rigid:RpNpK/VvfSb/vEdCTgnz9CpWXgI	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51116	uniprotkb:P12268	intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113	intact:EBI-353389|uniprotkb:Q6LEF3|ensembl:ENSP00000321584	psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym)	psi-mi:imdh2_human(display_long)|uniprotkb:IMPDH2(gene name)|psi-mi:IMPDH2(display_short)|uniprotkb:IMPD2(gene name synonym)|uniprotkb:Inosine-5'-monophosphate dehydrogenase type II(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511899|imex:IM-28561-979	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z	refseq:NP_000875.2|ensembl:ENSG00000178035(gene)|ensembl:ENST00000326739(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003938"(IMP dehydrogenase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006177"(GMP biosynthetic process)|go:"GO:0006183"(GTP biosynthetic process)|go:"GO:0007623"(circadian rhythm)|go:"GO:0016020"(membrane)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0046651"(lymphocyte proliferation)|go:"GO:0046872"(metal ion binding)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000644(Cystathionine beta-synthase, core)|interpro:IPR001093(IMP dehydrogenase/GMP reductase)|interpro:IPR005990(IMP dehydrogenase)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR015875(IMP dehydrogenase / GMP reductase, conserved site)|mint:P12268|rcsb pdb:1B3O|rcsb pdb:1NF7|rcsb pdb:1NFB|rcsb pdb:6I0M|rcsb pdb:6I0O|rcsb pdb:6U8E|rcsb pdb:6U8N|rcsb pdb:6U8R|rcsb pdb:6U8S|rcsb pdb:6U9O|rcsb pdb:6UA2|rcsb pdb:6UA4|rcsb pdb:6UA5|rcsb pdb:6UAJ|rcsb pdb:6UC2|rcsb pdb:6UDO|rcsb pdb:6UDP|rcsb pdb:6UDQ|reactome:R-HSA-6798695|reactome:R-HSA-73817|reactome:R-HSA-9679191	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606	rogid:qGPwBxhEgtYik3OetHZbpyktoLE9606	rigid:BCwMDWUw/QU72uSduNIGwp/dHJE	false	sufficient binding region:235-370	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51116	uniprotkb:P04792	intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113	intact:EBI-352682|uniprotkb:Q6FI47|uniprotkb:Q96C20|uniprotkb:Q96EI7|uniprotkb:Q9UC34|uniprotkb:Q9UC35|uniprotkb:Q9UC36|uniprotkb:Q9UC31|ensembl:ENSP00000248553|uniprotkb:B2R4N8	psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym)	psi-mi:hspb1_human(display_long)|uniprotkb:HSPB1(gene name)|psi-mi:HSPB1(display_short)|uniprotkb:HSP27(gene name synonym)|uniprotkb:HSP28(gene name synonym)|uniprotkb:Heat shock 27 kDa protein(gene name synonym)|uniprotkb:Stress-responsive protein 27(gene name synonym)|uniprotkb:Estrogen-regulated 24 kDa protein(gene name synonym)|uniprotkb:28 kDa heat shock protein(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511890|imex:IM-28561-559	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z	refseq:NP_001531.1|ensembl:ENSG00000106211(gene)|ensembl:ENST00000248553(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008426"(protein kinase C inhibitor activity)|go:"GO:0009615"(response to virus)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0038033"(positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|interpro:IPR001436(Alpha crystallin/Heat shock protein)|interpro:IPR002068(Heat shock protein Hsp20)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037876|mint:P04792|rcsb pdb:2N3J|rcsb pdb:3Q9P|rcsb pdb:3Q9Q|rcsb pdb:4MJH|rcsb pdb:6DV5|rcsb pdb:6GJH|reactome:R-HSA-4420097|reactome:R-HSA-450408|reactome:R-HSA-5687128|reactome:R-HSA-9009391|dip:DIP-412N	-	-	crc64:1B4DC44A6F6606D5	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606	rogid:vrDXIdzP30aHSDLHOh2D4x54eJY9606	rigid:NekwoQer2WWRyd+A2RPpXkY+P5E	false	sufficient binding region:235-370	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51116	uniprotkb:Q9NSC5	intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113	intact:EBI-748420|uniprotkb:O14580|uniprotkb:O95350|uniprotkb:Q9NSB9|uniprotkb:Q9NSC0|intact:EBI-2557809|uniprotkb:E9PCW9|uniprotkb:Q9NSC1|intact:EBI-28972925|ensembl:ENSP00000376162|ensembl:ENSP00000439937|ensembl:ENSP00000446026|intact:EBI-10175777|uniprotkb:B2RA10	psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym)	psi-mi:home3_human(display_long)|uniprotkb:HOMER3(gene name)|psi-mi:HOMER3(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511881|imex:IM-28561-1467	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z	ensembl:ENST00000221222|ensembl:ENSP00000221222|ensembl:ENSP00000376162|ensembl:ENST00000433218|ensembl:ENSP00000396154|ensembl:ENSP00000439937|ensembl:ENSP00000446026|ensembl:ENST00000594439|ensembl:ENSP00000471835|refseq:XP_006723006.1|refseq:XP_006723007.1|refseq:NP_001139193.1|refseq:NP_001139194.1|refseq:NP_004829.3|refseq:NP_001139196.1|ensembl:ENSG00000051128(gene)|ensembl:ENST00000392351(transcript)|ensembl:ENST00000539827(transcript)|ensembl:ENST00000542541(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006605"(protein targeting)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030425"(dendrite)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0035256"(G protein-coupled glutamate receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:2001256"(regulation of store-operated calcium entry)|interpro:IPR000697(EVH1)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR044100|mint:Q9NSC5|rcsb pdb:2P8V|rcsb pdb:3CVF|reactome:R-HSA-6794361	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606	rogid:U1y/y52nnf7zQUCNQlqk7JDgXi49606	rigid:bnRGe3+6PekN1Q/eOJRHx0Mwqdg	false	sufficient binding region:235-370	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51116	uniprotkb:O43390	intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113	intact:EBI-713419|uniprotkb:S4R3J4|uniprotkb:Q5TEH1|ensembl:ENSP00000304405|ensembl:ENSP00000363741|ensembl:ENSP00000489252|ensembl:ENSP00000489371|uniprotkb:Q9BV64|uniprotkb:Q2L7G6	psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym)	psi-mi:hnrpr_human(display_long)|uniprotkb:HNRPR(gene name synonym)|uniprotkb:HNRNPR(gene name)|psi-mi:HNRNPR(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511874|imex:IM-28561-757	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z	refseq:NP_001095868.1|refseq:XP_005245768.1|ensembl:ENSG00000125944(gene)|ensembl:ENSG00000282958(gene)|ensembl:ENST00000302271(transcript)|ensembl:ENST00000374612(transcript)|ensembl:ENST00000634263(transcript)|ensembl:ENST00000634766(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006397"(mRNA processing)|go:"GO:0007623"(circadian rhythm)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043679"(axon terminus)|go:"GO:0061157"(mRNA destabilization)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR006535(HnRNP R and Q splicing factor)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034411|interpro:IPR035979|mint:O43390|rcsb pdb:2DK2|reactome:R-HSA-72163|reactome:R-HSA-72203|interpro:IPR041337|refseq:NP_005817.1|refseq:XP_011538773.1|refseq:NP_001284549.1|refseq:XP_016855497.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606	rogid:UiOaRbnMd1S2FthR4RWltyq6xT49606	rigid:IfIyoFxPKBVsSlgbxIXJRPWx220	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51116	uniprotkb:Q86SE5	intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113	intact:EBI-741520|uniprotkb:Q6ZW87|uniprotkb:Q8N1C2|uniprotkb:B3KTH2|ensembl:ENSP00000428667|ensembl:ENSP00000430367|ensembl:ENSP00000430394|uniprotkb:G3V129	psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym)	psi-mi:ralyl_human(display_long)|uniprotkb:Heterogeneous nuclear ribonucleoprotein C-like 3(gene name synonym)|uniprotkb:RALYL(gene name)|psi-mi:RALYL(display_short)|uniprotkb:HNRPCL3(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512167|imex:IM-28561-121	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z	refseq:NP_001093861.1|refseq:NP_001093862.1|refseq:NP_001093863.1|refseq:NP_776247.3|ensembl:ENSG00000184672(gene)|ensembl:ENST00000521268(transcript)|ensembl:ENST00000521695(transcript)|ensembl:ENST00000522455(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0042802"(identical protein binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR017347(Heterogeneous nuclear ribonucleoprotein C, Raly)|interpro:IPR034504|interpro:IPR035979|mint:Q86SE5|refseq:NP_001274173.1|refseq:XP_016868548.1|refseq:XP_016868549.1|refseq:XP_016868550.1|refseq:XP_016868551.1|refseq:XP_016868552.1|refseq:XP_016868553.1|refseq:XP_016868554.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606	rogid:/dJc0rSACk93SMMAkFSfi2YdWuo9606	rigid:1P0vkzkY/Gigz7y+vQi4ZTfpbxE	false	sufficient binding region:235-370	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51116	uniprotkb:Q9Y5P3	intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113	intact:EBI-746228|uniprotkb:Q8N6X7|uniprotkb:B1B1K2|ensembl:ENSP00000333456|ensembl:ENSP00000353106|ensembl:ENSP00000401323|ensembl:ENSP00000444210|uniprotkb:B4DQM9|uniprotkb:E7EMN4	psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym)	psi-mi:rai2_human(display_long)|uniprotkb:RAI2(gene name)|psi-mi:RAI2(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512158|imex:IM-28561-1685	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z	refseq:NP_001166214.1|refseq:XP_011543741.1|refseq:XP_011543742.1|refseq:XP_011543743.1|ensembl:ENSG00000131831(gene)|ensembl:ENST00000331511(transcript)|ensembl:ENST00000360011(transcript)|ensembl:ENST00000451717(transcript)|ensembl:ENST00000545871(transcript)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|interpro:IPR026092|mint:Q9Y5P3|refseq:NP_001166203.1|refseq:XP_006724522.1|refseq:XP_006724523.1|refseq:NP_001166210.1|refseq:NP_068557.3	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606	rogid:cQ4QQAp6lbQjIvn9xzXPRfUBEzo9606	rigid:hu0+XWwNi3HB3sBNetccY7K1mlM	false	sufficient binding region:235-370	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51116	uniprotkb:Q9Y4B4	intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113	intact:EBI-948156|uniprotkb:Q8TB57|uniprotkb:Q9BV54|intact:EBI-28975962|ensembl:ENSP00000386520|ensembl:ENSP00000507587	psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym)	psi-mi:arip4_human(display_long)|uniprotkb:ARIP4(gene name synonym)|uniprotkb:KIAA0809(gene name synonym)|uniprotkb:Androgen receptor-interacting protein 4(gene name synonym)|uniprotkb:RAD54-like protein 2(gene name synonym)|uniprotkb:RAD54L2(gene name)|psi-mi:RAD54L2(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512149|imex:IM-28561-771	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z	ensembl:ENSP00000386520|ensembl:ENSP00000507587|refseq:NP_055921.2|refseq:NP_001309182.1|refseq:NP_001309185.1|ensembl:ENSG00000164080(gene)|ensembl:ENST00000409535(transcript)|ensembl:ENST00000684192(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0070615"|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR000330(SNF2-related)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR038718|interpro:IPR044573|interpro:IPR044574|mint:Q9Y4B4|refseq:XP_006713125.1|refseq:XP_016861476.1|refseq:XP_016861477.1|dip:DIP-47284N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606	rogid:zqpCSF3VF9OddWH5I84o4fDkoMM9606	rigid:kU/EIxL6EmzIteC2VEmnUGr3ZDQ	false	sufficient binding region:235-370	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51116	uniprotkb:Q53H96	intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113	intact:EBI-2959680|ensembl:ENSP00000480945|ensembl:ENSP00000488371|uniprotkb:Q9H896|uniprotkb:Q8N3N9|uniprotkb:B3KMB5|uniprotkb:Q96HX4|uniprotkb:B4DVT6|uniprotkb:H0Y6C3	psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym)	psi-mi:p5cr3_human(display_long)|uniprotkb:PYCR3(gene name)|psi-mi:PYCR3(display_short)|uniprotkb:PYCRL(gene name synonym)|uniprotkb:Pyrroline-5-carboxylate reductase-like protein(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512140|imex:IM-28561-1201	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z	ensembl:ENST00000495276(transcript)|ensembl:ENST00000632107(transcript)|go:"GO:0004735"(pyrroline-5-carboxylate reductase activity)|go:"GO:0005829"(cytosol)|go:"GO:0045171"(intercellular bridge)|go:"GO:0055129"(L-proline biosynthetic process)|go:"GO:0072686"(mitotic spindle)|interpro:IPR000304(Delta 1-pyrroline-5-carboxylate reductase)|interpro:IPR008927(6-phosphogluconate dehydrogenase, C-terminal-like)|interpro:IPR028939|interpro:IPR029036|interpro:IPR036291|mint:Q53H96|reactome:R-HSA-8964539|ensembl:ENSG00000276657(gene)|ensembl:ENSG00000104524(gene)|refseq:NP_075566.2|refseq:NP_001316795.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606	rogid:n2snI64kwT1vICZ4DA9tmdtS4vU9606	rigid:ARqJgqZw1+TgrMjwhSwW5ygtBFI	false	sufficient binding region:235-370	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51116	uniprotkb:Q96C36	intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113	intact:EBI-358366|uniprotkb:Q7Z515|uniprotkb:Q9Y5J4|ensembl:ENSP00000342502|uniprotkb:A8K798	psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym)	psi-mi:p5cr2_human(display_long)|uniprotkb:PYCR2(gene name)|psi-mi:PYCR2(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512131|imex:IM-28561-329	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z	refseq:NP_037460.2|ensembl:ENSG00000143811(gene)|ensembl:ENST00000343818(transcript)|go:"GO:0004735"(pyrroline-5-carboxylate reductase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006561"(proline biosynthetic process)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0055129"(L-proline biosynthetic process)|interpro:IPR000304(Delta 1-pyrroline-5-carboxylate reductase)|interpro:IPR008927(6-phosphogluconate dehydrogenase, C-terminal-like)|interpro:IPR028939|interpro:IPR029036|interpro:IPR036291|mint:Q96C36|rcsb pdb:6LHM|reactome:R-HSA-8964539|refseq:NP_001258610.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606	rogid:lIjn88RdpxuNpN+fgVPZV2bjubA9606	rigid:P4lK70yj4Gwfs6C6tdmMOM5HyCQ	false	sufficient binding region:235-370	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51116	uniprotkb:P61289	intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113	intact:EBI-355546|uniprotkb:O35563|uniprotkb:P97373|uniprotkb:Q12920|uniprotkb:Q13172|uniprotkb:Q9BQD9|uniprotkb:A8K9A3|ensembl:ENSP00000466794	psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym)	psi-mi:psme3_human(display_long)|uniprotkb:PSME3(gene name)|psi-mi:PSME3(display_short)|uniprotkb:Proteasome activator 28 subunit gamma(gene name synonym)|uniprotkb:Activator of multicatalytic protease subunit 3(gene name synonym)|uniprotkb:11S regulator complex subunit gamma(gene name synonym)|uniprotkb:Ki nuclear autoantigen(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512122|imex:IM-28561-565	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z	refseq:NP_005780.2|refseq:NP_789839.1|ensembl:ENSG00000131467(gene)|ensembl:ENST00000590720(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0002039"(p53 binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008537"(proteasome activator complex)|go:"GO:0010950"(positive regulation of endopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR003185(Proteasome activator pa28, REG alpha subunit)|interpro:IPR003186(Proteasome activator pa28, REG beta subunit)|interpro:IPR009077(Proteasome activator pa28, REG alpha/beta subunit)|interpro:IPR036252|interpro:IPR036996|interpro:IPR036997|mint:P61289|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606	rogid:6EQY2Kj3Juf++m4eBDzPWMgbC2k9606	rigid:URN4DbgvKntuGhfa0a5fJlQH1Ts	false	sufficient binding region:235-370	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51116	uniprotkb:Q06323	intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113	intact:EBI-712149|uniprotkb:H0YNE3|ensembl:ENSP00000206451|ensembl:ENSP00000495095|uniprotkb:Q9UEF4|uniprotkb:Q6IBM2|uniprotkb:A6NJG9	psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym)	psi-mi:psme1_human(display_long)|uniprotkb:Proteasome activator 28 subunit alpha(gene name synonym)|uniprotkb:Activator of multicatalytic protease subunit 1(gene name synonym)|uniprotkb:11S regulator complex subunit alpha(gene name synonym)|uniprotkb:Interferon gamma up-regulated I-5111 protein(gene name synonym)|uniprotkb:PSME1(gene name)|psi-mi:PSME1(display_short)|uniprotkb:IFI5111(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512113|imex:IM-28561-987	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z	reactome:R-HSA-5678895|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-5687128|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|ensembl:ENSG00000092010(gene)|ensembl:ENSG00000284916(gene)|ensembl:ENST00000206451(transcript)|ensembl:ENST00000645537(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008537"(proteasome activator complex)|go:"GO:0010950"(positive regulation of endopeptidase activity)|go:"GO:0019884"(antigen processing and presentation of exogenous antigen)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR003185(Proteasome activator pa28, REG alpha subunit)|interpro:IPR003186(Proteasome activator pa28, REG beta subunit)|interpro:IPR009077(Proteasome activator pa28, REG alpha/beta subunit)|interpro:IPR036252|interpro:IPR036996|interpro:IPR036997|mint:Q06323|rcsb pdb:1AVO|rcsb pdb:7DR6|rcsb pdb:7DRW|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|refseq:NP_006254.1|refseq:NP_001268457.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606	rogid:kyTjI3VP2S7Bvwq4R0pJudnlOC09606	rigid:/HVNDWeVqe4Op31dH7i4KZvgu/o	false	sufficient binding region:235-370	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51116	uniprotkb:Q9BZL4	intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113	intact:EBI-721802|uniprotkb:Q59FK8|uniprotkb:Q6ZPD1|uniprotkb:Q7L8F7|uniprotkb:Q9H5H5|uniprotkb:Q9NT00|uniprotkb:Q96HW1|uniprotkb:B4DME2|ensembl:ENSP00000263433	psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym)	psi-mi:pp12c_human(display_long)|uniprotkb:LENG3(gene name synonym)|uniprotkb:MBS85(gene name synonym)|uniprotkb:Protein phosphatase 1 myosin-binding subunit of 85 kDa(gene name synonym)|uniprotkb:PPP1R12C(gene name)|psi-mi:PPP1R12C(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512104|imex:IM-28561-327	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z	refseq:NP_060077.1|refseq:NP_001258547.1|refseq:XP_005259070.1|ensembl:ENSG00000125503(gene)|ensembl:ENST00000263433(transcript)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007165"(signal transduction)|go:"GO:0019208"(phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|interpro:IPR002110(Ankyrin)|interpro:IPR017401(Protein phosphatase 1, regulatory subunits 12A/B/C, eukaryote)|interpro:IPR020683|interpro:IPR031205|interpro:IPR031775|interpro:IPR036770|mint:Q9BZL4	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606	rogid:q24mbt02IydCWtQyNXmNVWav/i89606	rigid:k1t0Sm0YIpSXEdUaMb7sjaastZU	false	sufficient binding region:235-370	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51116	uniprotkb:Q8ND90	intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113	intact:EBI-302345|uniprotkb:O95144|uniprotkb:Q8NG07|ensembl:ENSP00000318914|uniprotkb:A8K4L5	psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym)	psi-mi:pnma1_human(display_long)|uniprotkb:PNMA1(gene name)|psi-mi:PNMA1(display_short)|uniprotkb:MA1(gene name synonym)|uniprotkb:Neuron- and testis-specific protein 1(gene name synonym)|uniprotkb:37 kDa neuronal protein(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512095|imex:IM-28561-1199	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z	refseq:NP_006020.4|ensembl:ENSG00000176903(gene)|ensembl:ENST00000316836(transcript)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0043065"(positive regulation of apoptotic process)|interpro:IPR026523|interpro:IPR026528|mint:Q8ND90	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606	rogid:/lx3CB7d/dv4xIgWQrCETPA0Qcw9606	rigid:ZMH28q6hdJGyh3sqrrfw1slbf4Q	false	sufficient binding region:235-370	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51116	uniprotkb:P14618	intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113	intact:EBI-353408|uniprotkb:A6NFK3|uniprotkb:P14786|uniprotkb:Q53GK4|uniprotkb:Q96E76|uniprotkb:Q9BWB5|uniprotkb:Q9UPF2|uniprotkb:B2R5N8|uniprotkb:B3KRY0|uniprotkb:B4DFX8|uniprotkb:Q9UCV6|intact:EBI-2555890|uniprotkb:B4DUU6|ensembl:ENSP00000334983	psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym)	psi-mi:kpym_human(display_long)|uniprotkb:PKM(gene name)|psi-mi:PKM(display_short)|uniprotkb:Cytosolic thyroid hormone-binding protein(gene name synonym)|uniprotkb:OIP3(gene name synonym)|uniprotkb:Opa-interacting protein 3(gene name synonym)|uniprotkb:PK2(gene name synonym)|uniprotkb:PK3(gene name synonym)|uniprotkb:PKM2(gene name synonym)|uniprotkb:Pyruvate kinase 2/3(gene name synonym)|uniprotkb:Pyruvate kinase muscle isozyme(gene name synonym)|uniprotkb:Thyroid hormone-binding protein 1(gene name synonym)|uniprotkb:Tumor M2-PK(gene name synonym)|uniprotkb:p58(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512086|imex:IM-28561-563	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z	refseq:NP_001193725.1|refseq:NP_001193727.1|refseq:NP_001193728.1|refseq:NP_002645.3|refseq:NP_872270.1|refseq:NP_872271.1|refseq:NP_001193726.1|refseq:NP_001303247.1|refseq:XP_005254502.1|dip:DIP-31273N|ensembl:ENSG00000067225(gene)|ensembl:ENST00000335181(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004743"(pyruvate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0006096"(glycolytic process)|go:"GO:0012501"(programmed cell death)|go:"GO:0016301"(kinase activity)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031982"(vesicle)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0045296"(cadherin binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2000767"(positive regulation of cytoplasmic translation)|interpro:IPR001697(Pyruvate kinase)|interpro:IPR011037(Pyruvate kinase, beta-barrel-like)|interpro:IPR015793(Pyruvate kinase, barrel)|interpro:IPR015795(Pyruvate kinase, C-terminal-like)|interpro:IPR015806(Pyruvate kinase, beta-barrel)|interpro:IPR015813(Pyruvate/Phosphoenolpyruvate kinase, catalytic core)|interpro:IPR018209|interpro:IPR036918|interpro:IPR040442|mint:P14618|rcsb pdb:1T5A|rcsb pdb:1ZJH|rcsb pdb:3BJF|rcsb pdb:3BJT|rcsb pdb:3G2G|rcsb pdb:3GQY|rcsb pdb:3GR4|rcsb pdb:3H6O|rcsb pdb:3ME3|rcsb pdb:3SRD|rcsb pdb:3SRF|rcsb pdb:3U2Z|rcsb pdb:4B2D|rcsb pdb:4FXF|rcsb pdb:4FXJ|rcsb pdb:4G1N|rcsb pdb:4JPG|rcsb pdb:4QG6|rcsb pdb:4QG8|rcsb pdb:4QG9|rcsb pdb:4QGC|rcsb pdb:4RPP|rcsb pdb:4WJ8|rcsb pdb:4YJ5|rcsb pdb:5X0I|rcsb pdb:5X1V|rcsb pdb:5X1W|rcsb pdb:6B6U|rcsb pdb:6GG3|rcsb pdb:6GG4|rcsb pdb:6GG5|rcsb pdb:6GG6|rcsb pdb:6JFB|rcsb pdb:6NU1|rcsb pdb:6NU5|rcsb pdb:6NUB|rcsb pdb:6TTF|rcsb pdb:6TTH|rcsb pdb:6TTI|rcsb pdb:6TTQ|rcsb pdb:6V74|rcsb pdb:3SRH|rcsb pdb:6V75|rcsb pdb:6V76|rcsb pdb:6WP3|rcsb pdb:6WP4|rcsb pdb:6WP5|rcsb pdb:6WP6|reactome:R-HSA-6798695|reactome:R-HSA-70171|refseq:XP_016877802.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606	rogid:dDaoXCaqd0x6qFSElvngHusttuk9606	rigid:NIwZbIA5pvZyDiilOyp+kzroqlU	false	sufficient binding region:235-370	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51116	uniprotkb:Q9NRD5	intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113	intact:EBI-79165|uniprotkb:O95906|ensembl:ENSP00000349465|ensembl:ENSP00000385205|intact:EBI-2622151|uniprotkb:B3KS52	psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym)	psi-mi:pick1_human(display_long)|uniprotkb:PICK1(gene name)|psi-mi:PICK1(display_short)|uniprotkb:PRKCABP(gene name synonym)|uniprotkb:Protein kinase C-alpha-binding protein(gene name synonym)|uniprotkb:Protein interacting with C kinase 1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512077|imex:IM-28561-325	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z	ensembl:ENSG00000100151(gene)|ensembl:ENST00000356976(transcript)|ensembl:ENST00000404072(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|refseq:NP_001034672.1|refseq:NP_001034673.1|refseq:NP_036539.1|go:"GO:0015844"(monoamine transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021782"(glial cell development)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0034315"(regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0034316"(negative regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0036294"(cellular response to decreased oxygen levels)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0043113"(receptor clustering)|go:"GO:0045161"(neuronal ion channel clustering)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051015"(actin filament binding)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0098842"(postsynaptic early endosome)|go:"GO:0140090"(membrane curvature sensor activity)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR010504(Arfaptin-like)|interpro:IPR027267|interpro:IPR030798|interpro:IPR036034|interpro:IPR037959|mint:Q9NRD5|rcsb pdb:2GZV|rcsb pdb:6AR4|rcsb pdb:6BJN|rcsb pdb:6BJO|reactome:R-HSA-202733|reactome:R-HSA-416993	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606	rogid:qRx+eNG7We8Oe0SQOekqpJpn8zk9606	rigid:bpyHArQobxPbaPgzanOSZ9bWEtE	false	sufficient binding region:235-370	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51116	uniprotkb:Q86UU1	intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113	intact:EBI-4289858|uniprotkb:Q4KMF8|uniprotkb:Q8TEQ2|uniprotkb:O75133|uniprotkb:B0YJ63|uniprotkb:B0YJ64|intact:EBI-28975144|ensembl:ENSP00000354498|ensembl:ENSP00000469820	psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym)	psi-mi:phlb1_human(display_long)|uniprotkb:PHLDB1(gene name)|psi-mi:PHLDB1(display_short)|uniprotkb:KIAA0638(gene name synonym)|uniprotkb:LL5A(gene name synonym)|uniprotkb:Protein LL5-alpha(gene name synonym)|uniprotkb:DLNB07(orf name)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512070|imex:IM-28561-769	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z	ensembl:ENST00000356063|ensembl:ENSP00000348359|ensembl:ENSP00000354498|ensembl:ENST00000528594|ensembl:ENSP00000435520|ensembl:ENST00000530994|ensembl:ENSP00000431508|ensembl:ENSP00000469820|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR037810|mint:Q86UU1|ensembl:ENSG00000019144(gene)|ensembl:ENST00000361417(transcript)|ensembl:ENST00000600882(transcript)|go:"GO:0010470"(regulation of gastrulation)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0045180"(basal cortex)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:1904261"(positive regulation of basement membrane assembly involved in embryonic body morphogenesis)|interpro:IPR000253(Forkhead-associated)|interpro:IPR001849(Pleckstrin-like)|refseq:NP_001138230.1|refseq:NP_001138231.1|refseq:NP_055972.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606	rogid:Za4UuXVuMr4gzY2kr8EadOf5hWA9606	rigid:h1GCbHMHtfN91lqhmFTW7OsWW5c	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51116	uniprotkb:Q8IXK0	intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113	intact:EBI-713786|uniprotkb:Q8N306|uniprotkb:Q8TAG8|uniprotkb:A1L4Q1|uniprotkb:Q2TAL3|uniprotkb:Q5T0C1|uniprotkb:Q6NUJ6|uniprotkb:Q6ZQR1|uniprotkb:Q96BL4|uniprotkb:Q9Y4Y7|ensembl:ENSP00000257118|uniprotkb:D3DPR2|uniprotkb:A8KA40	psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym)	psi-mi:phc2_human(display_long)|uniprotkb:Early development regulatory protein 2(gene name synonym)|uniprotkb:PHC2(gene name)|psi-mi:PHC2(display_short)|uniprotkb:EDR2(gene name synonym)|uniprotkb:PH2(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512063|imex:IM-28561-1477	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z	interpro:IPR038603|mint:Q8IXK0|reactome:R-HSA-2559580|reactome:R-HSA-3108214|reactome:R-HSA-3899300|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4655427|reactome:R-HSA-8939243|reactome:R-HSA-8943724|interpro:IPR013761(Sterile alpha motif-type)|ensembl:ENSG00000134686(gene)|ensembl:ENST00000257118(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0031519"(PcG protein complex)|go:"GO:0035102"(PRC1 complex)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR012313(Zinc finger, FCS-type)|refseq:NP_004418.2|refseq:NP_932157.1|refseq:XP_016856005.1|refseq:XP_016856006.1|refseq:XP_016856007.1|refseq:XP_005270627.1|dip:DIP-34464N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606	rogid:7si/KU2tHoxviuCr70ncQERDWmY9606	rigid:EJ4yv3jRmHfsyXOpNCxRzM8o0RI	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51116	uniprotkb:O76083	intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113	intact:EBI-742764|uniprotkb:O75490|uniprotkb:O75491|uniprotkb:O95225|uniprotkb:Q86SF7|uniprotkb:Q86SI6|uniprotkb:Q86SJ3|uniprotkb:Q86WN3|uniprotkb:Q86WN4|uniprotkb:Q86WN5|uniprotkb:Q86WN6|uniprotkb:Q86WN7|uniprotkb:Q86WN8|uniprotkb:Q86WN9|uniprotkb:Q86WP0|uniprotkb:B2RBI5|uniprotkb:Q53Y40|uniprotkb:B4DFI5|uniprotkb:Q5QD39|uniprotkb:D3DSJ8|uniprotkb:D3DSJ9|ensembl:ENSP00000291539	psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym)	psi-mi:pde9a_human(display_long)|uniprotkb:PDE9A(gene name)|psi-mi:PDE9A(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512056|imex:IM-28561-985	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z	rcsb pdb:3DYS|refseq:NP_001001567.1|refseq:NP_001001568.1|refseq:NP_001001569.1|refseq:NP_001001570.1|refseq:NP_001001571.1|refseq:NP_001001572.1|refseq:NP_001001573.1|refseq:NP_001001574.1|refseq:NP_001001575.1|refseq:NP_001001576.1|refseq:NP_001001577.1|refseq:NP_001001578.1|refseq:NP_001001579.1|refseq:NP_001001580.1|refseq:NP_001001581.1|refseq:NP_001001582.1|refseq:NP_001001583.1|refseq:NP_001001584.1|refseq:NP_001001585.1|refseq:NP_002597.1|refseq:NP_001302462.1|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0046068"(cGMP metabolic process)|go:"GO:0046069"(cGMP catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0047555"(3',5'-cyclic-GMP phosphodiesterase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR002073(3'5'-cyclic nucleotide phosphodiesterase)|interpro:IPR003607(Metal-dependent phosphohydrolase, HD region)|interpro:IPR023088|ensembl:ENSG00000160191(gene)|ensembl:ENST00000291539(transcript)|go:"GO:0004114"(3',5'-cyclic-nucleotide phosphodiesterase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0032587"(ruffle membrane)|interpro:IPR023174|interpro:IPR036971|mint:O76083|rcsb pdb:2HD1|rcsb pdb:2YY2|rcsb pdb:3DY8|rcsb pdb:3DYL|rcsb pdb:3DYN|rcsb pdb:3DYQ|rcsb pdb:3JSW|rcsb pdb:3K3E|rcsb pdb:3K3H|rcsb pdb:3N3Z|rcsb pdb:3QI3|rcsb pdb:3QI4|rcsb pdb:4E90|rcsb pdb:4G2J|rcsb pdb:4G2L|rcsb pdb:4GH6|rcsb pdb:4Y86|rcsb pdb:4Y87|rcsb pdb:4Y8C|rcsb pdb:6A3N|rcsb pdb:6LZZ|reactome:R-HSA-418457|rcsb pdb:3JSI|refseq:XP_016883855.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606	rogid:ihS9g9TSkHsEA4olMOO+krgypow9606	rigid:huqsTRW8tb70dA1aJQ7a2YMB+rs	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51116	uniprotkb:P22234	intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113	intact:EBI-712261|ensembl:ENSP00000264221|ensembl:ENSP00000421096|uniprotkb:E9PDH9|uniprotkb:Q68CQ5|intact:EBI-21352784	psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym)	psi-mi:pur6_human(display_long)|uniprotkb:PAICS(gene name)|psi-mi:PAICS(display_short)|uniprotkb:ADE2(gene name synonym)|uniprotkb:AIRC(gene name synonym)|uniprotkb:PAIS(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512049|imex:IM-28561-1683	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z	ensembl:ENSG00000128050(gene)|ensembl:ENST00000264221(transcript)|ensembl:ENST00000512576(transcript)|go:"GO:0004639"(phosphoribosylaminoimidazolesuccinocarboxamide synthase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006189"('de novo' IMP biosynthetic process)|go:"GO:0009113"(purine nucleobase biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043727"(5-amino-4-imidazole carboxylate lyase activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000031("1-(5-Phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase")|interpro:IPR018236|interpro:IPR028923|interpro:IPR033626|mint:P22234|rcsb pdb:2H31|rcsb pdb:6YB8|go:"GO:0004638"(phosphoribosylaminoimidazole carboxylase activity)|rcsb pdb:6YB9|reactome:R-HSA-73817|refseq:NP_001072992.1|refseq:NP_001072993.1|refseq:NP_006443.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606	rogid:aR4Xj14ZQrPiY8cldw5o9AvjkAo9606	rigid:WF2JcoPmSVn4yK5uiEnbVNMRIdg	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51116	uniprotkb:P48745	intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113	intact:EBI-3904822|uniprotkb:Q6I9S3|uniprotkb:Q9UDE4|uniprotkb:Q96BY5|uniprotkb:B2R5X7|ensembl:ENSP00000259526	psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym)	psi-mi:ccn3_human(display_long)|uniprotkb:CCN3(gene name)|psi-mi:CCN3(display_short)|uniprotkb:Cellular communication network factor 3(gene name synonym)|uniprotkb:IGFBP9(gene name synonym)|uniprotkb:Insulin-like growth factor-binding protein 9(gene name synonym)|uniprotkb:NOV(gene name synonym)|uniprotkb:NOVH(gene name synonym)|uniprotkb:Nephro blastoma-overexpressed gene protein homolog(gene name synonym)|uniprotkb:Protein NOV homolog(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512040|imex:IM-28561-767	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z	refseq:NP_002505.1|ensembl:ENSG00000136999(gene)|ensembl:ENST00000259526(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0005112"(Notch binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005921"(gap junction)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010761"(fibroblast migration)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0014909"(smooth muscle cell migration)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031012"(extracellular matrix)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0035767"(endothelial cell chemotaxis)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044342"(type B pancreatic cell proliferation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0048659"(smooth muscle cell proliferation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060392"(negative regulation of SMAD protein signal transduction)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061484"(hematopoietic stem cell homeostasis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071603"(endothelial cell-cell adhesion)|go:"GO:0090027"(negative regulation of monocyte chemotaxis)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1902731"(negative regulation of chondrocyte proliferation)|go:"GO:1904057"(negative regulation of sensory perception of pain)|go:"GO:1990523"(bone regeneration)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR006208(Cystine knot)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR012395(IGFBP-related, CNN)|interpro:IPR017891|interpro:IPR036383|interpro:IPR043973|mint:P48745	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606	rogid:3IUgIO3Q676ryvJXOCfCvHmcC789606	rigid:zul7+L/WBTrT6jkQnFI2hb9YNAE	false	sufficient binding region:235-370	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51116	uniprotkb:Q13232	intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113	intact:EBI-713684|uniprotkb:Q9BWH4|ensembl:ENSP00000219302	psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym)	psi-mi:ndk3_human(display_long)|uniprotkb:Nucleoside diphosphate kinase C(gene name synonym)|uniprotkb:nm23-H3(gene name synonym)|uniprotkb:DR-nm23(gene name synonym)|uniprotkb:NME3(gene name)|psi-mi:NME3(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512031|imex:IM-28561-765	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z	ensembl:ENSG00000103024(gene)|ensembl:ENST00000219302(transcript)|go:"GO:0004550"(nucleoside diphosphate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006183"(GTP biosynthetic process)|go:"GO:0006228"(UTP biosynthetic process)|go:"GO:0006241"(CTP biosynthetic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0046872"(metal ion binding)|interpro:IPR001564(Nucleoside diphosphate kinase, core)|interpro:IPR023005|interpro:IPR034907|interpro:IPR036850|mint:Q13232|rcsb pdb:1ZS6|reactome:R-HSA-499943|refseq:NP_002504.2|dip:DIP-49960N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606	rogid:/egrHNJSuCILf6NdwwchG9rUGqI9606	rigid:CX6fOpYxAPp/K6eEEwcgfr6Vhqw	false	sufficient binding region:235-370	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51116	uniprotkb:P15531	intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113	intact:EBI-741141|ensembl:ENSP00000376892|uniprotkb:Q6FGK3|uniprotkb:Q86XQ2|uniprotkb:Q9UDJ6	psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym)	psi-mi:ndka_human(display_long)|uniprotkb:Tumor metastatic process-associated protein(gene name synonym)|uniprotkb:Metastasis inhibition factor nm23(gene name synonym)|uniprotkb:Granzyme A-activated DNase(gene name synonym)|uniprotkb:NME1(gene name)|psi-mi:NME1(display_short)|uniprotkb:NDPKA(gene name synonym)|uniprotkb:NM23(gene name synonym)|uniprotkb:NM23-H1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512022|imex:IM-28561-763	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z	refseq:NP_000260.1|refseq:NP_937818.1|ensembl:ENSG00000239672(gene)|ensembl:ENST00000393196(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0002762"(negative regulation of myeloid leukocyte differentiation)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004536"(deoxyribonuclease activity)|go:"GO:0004550"(nucleoside diphosphate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0006183"(GTP biosynthetic process)|go:"GO:0006228"(UTP biosynthetic process)|go:"GO:0006241"(CTP biosynthetic process)|go:"GO:0006897"(endocytosis)|go:"GO:0007595"(lactation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014075"(response to amine)|go:"GO:0016020"(membrane)|go:"GO:0019215"(intermediate filament binding)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051591"(response to cAMP)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071398"(cellular response to fatty acid)|interpro:IPR001564(Nucleoside diphosphate kinase, core)|go:"GO:0019899"(enzyme binding)|interpro:IPR023005|go:"GO:0021766"(hippocampus development)|interpro:IPR034907|interpro:IPR036850|mint:P15531|go:"GO:0030154"(cell differentiation)|go:"GO:0032587"(ruffle membrane)|rcsb pdb:1JXV|rcsb pdb:1UCN|go:"GO:0033574"(response to testosterone)|go:"GO:0035690"|rcsb pdb:2HVD|rcsb pdb:2HVE|rcsb pdb:3L7U|rcsb pdb:4ENO|rcsb pdb:5UI4|reactome:R-HSA-499943|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043024"(ribosomal small subunit binding)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|dip:DIP-39164N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606	rogid:Ut4gK1Xq786CaZzvqdS1eiU5op89606	rigid:16jCoZwOCQ8jVi3mIRoUn7pPyf0	false	sufficient binding region:235-370	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q969F2	uniprotkb:P51116	intact:EBI-1538629|uniprotkb:Q96EK8|uniprotkb:Q9BSN0|ensembl:ENSP00000296849|ensembl:ENSP00000479003	intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113	psi-mi:nkd2_human(display_long)|uniprotkb:NKD2(gene name)|psi-mi:NKD2(display_short)	psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512013|imex:IM-28561-761	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_149111.1|refseq:NP_001258011.1|ensembl:ENST00000274150|ensembl:ENSP00000274150|ensembl:ENSP00000296849|ensembl:ENST00000610777|ensembl:ENSP00000482896|ensembl:ENSP00000479003|dip:DIP-38642N|ensembl:ENSG00000145506(gene)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019838"(growth factor binding)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032036"(myosin heavy chain binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0048210"(Golgi vesicle fusion to target membrane)|ensembl:ENSG00000276920(gene)|ensembl:ENST00000296849(transcript)|ensembl:ENST00000616539(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0051117"(ATPase binding)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0071944"(cell periphery)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR040140|mint:Q969F2	interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:kQxbG3sbnbXPkaywAkvN6ip1+Bw9606	rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606	rigid:NuTxWDWmmGKftvpO7BjB4VCDRuQ	false	-	sufficient binding region:235-370	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51116	uniprotkb:Q7Z6G3	intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113	intact:EBI-950070|ensembl:ENSP00000307449|uniprotkb:A2RRG3|uniprotkb:O75547|uniprotkb:Q6ZSK0|uniprotkb:H3BTW2	psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym)	psi-mi:neca2_human(display_long)|uniprotkb:Neuronal calcium-binding protein 2(gene name synonym)|uniprotkb:Synaptotagmin-interacting protein 2(gene name synonym)|uniprotkb:NECAB2(gene name)|psi-mi:NECAB2(display_short)|uniprotkb:EFCBP2(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512004|imex:IM-28561-323	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z	ensembl:ENSG00000103154(gene)|ensembl:ENST00000305202(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031687"(A2A adenosine receptor binding)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042984"(regulation of amyloid precursor protein biosynthetic process)|go:"GO:0060168"(positive regulation of adenosine receptor signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1904021"(negative regulation of G protein-coupled receptor internalization)|go:"GO:1905477"(positive regulation of protein localization to membrane)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR007138(Antibiotic biosynthesis monooxygenase)|interpro:IPR011008(Dimeric alpha-beta barrel)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR039862|mint:Q7Z6G3|refseq:NP_061938.2|refseq:NP_001316678.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606	rogid:Op/JNOBupSCF1U3MCeNmJ6gUUrg9606	rigid:tMhsi0/94mUx8ybGIlsN4s3ShHw	false	sufficient binding region:235-370	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51116	uniprotkb:P49321	intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113	intact:EBI-716205|uniprotkb:Q53GW5|uniprotkb:Q5T625|uniprotkb:Q5T622|uniprotkb:Q96A69|uniprotkb:Q9BTW2|uniprotkb:A8K6H2|uniprotkb:B4DQP3|uniprotkb:F5H3J2|uniprotkb:D3DQ07|intact:EBI-28989159|ensembl:ENSP00000255120	psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym)	psi-mi:nasp_human(display_long)|uniprotkb:NASP(gene name)|psi-mi:NASP(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26511997|imex:IM-28561-983	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z	refseq:NP_001182122.1|refseq:NP_002473.2|refseq:NP_689511.2|ensembl:ENSG00000132780(gene)|ensembl:ENST00000350030(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000785"(chromatin)|go:"GO:0001824"(blastocyst development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0008584"(male gonad development)|go:"GO:0015031"(protein transport)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033574"(response to testosterone)|go:"GO:0034080"(CENP-A containing chromatin assembly)|go:"GO:0042393"(histone binding)|go:"GO:0043486"(histone exchange)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019544|interpro:IPR019734|mint:P49321|ensembl:ENSP00000255120|ensembl:ENST00000351223|ensembl:ENSP00000255121|ensembl:ENST00000537798|ensembl:ENSP00000438871|refseq:XP_005270945.1|dip:DIP-47269N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606	rogid:8BOknyp+vOh6NF+fXZPYbbqFbH49606	rigid:jsmNn4GaVaZ1Ct/Z3wTuQIrLu3g	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51116	uniprotkb:Q8IUH3	intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113	intact:EBI-2512147|ensembl:ENSP00000482083|uniprotkb:Q8NFC9|uniprotkb:Q6NYL0	psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym)	psi-mi:rbm45_human(display_long)|uniprotkb:RBM45(gene name)|psi-mi:RBM45(display_short)|uniprotkb:DRB1(gene name synonym)|uniprotkb:DRBP1(gene name synonym)|uniprotkb:RNA-binding motif protein 45(gene name synonym)|uniprotkb:Developmentally-regulated RNA-binding protein 1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512176|imex:IM-28561-989	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z	ensembl:ENSG00000155636(gene)|ensembl:ENST00000616198(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0007399"(nervous system development)|go:"GO:0030154"(cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033101|interpro:IPR034203|interpro:IPR034206|interpro:IPR034207|interpro:IPR034208|interpro:IPR035979|mint:Q8IUH3|rcsb pdb:7CSX|rcsb pdb:7CSZ|go:"GO:0005634"(nucleus)|refseq:NP_694453.2|refseq:XP_005246344.1|refseq:XP_016858811.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606	rogid:8w7mWJ1ncdOyq9VCGIIYK3qapxY9606	rigid:hdDGkj+Rw0oAEYsxhgw2IcmJsl4	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51116	uniprotkb:Q13435	intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113	intact:EBI-749111|uniprotkb:A8K485|uniprotkb:B4DT19|uniprotkb:Q7Z627|uniprotkb:Q969K1|uniprotkb:Q96CM6|uniprotkb:Q9BWD2|intact:EBI-1052093|intact:EBI-2688256|uniprotkb:Q7L4T5|ensembl:ENSP00000318861	psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym)	psi-mi:sf3b2_human(display_long)|uniprotkb:SF3B2(gene name)|psi-mi:SF3B2(display_short)|uniprotkb:SAP145(gene name synonym)|uniprotkb:Pre-mRNA-splicing factor SF3b 145 kDa subunit(gene name synonym)|uniprotkb:Spliceosome-associated protein 145(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512192|imex:IM-28561-1687	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z	refseq:NP_006833.2|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005684"(U2-type spliceosomal complex)|go:"GO:0005686"(U2 snRNP)|go:"GO:0005689"(U12-type spliceosomal complex)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|interpro:IPR003034(DNA-binding SAP)|interpro:IPR006568(PSP, proline-rich)|ensembl:ENSG00000087365(gene)|ensembl:ENST00000322535(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|interpro:IPR007180(Protein of unknown function DUF382)|rcsb pdb:2DO5|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6FF4|rcsb pdb:6FF7|rcsb pdb:6QX9|rcsb pdb:6Y50|rcsb pdb:6Y53|mint:Q13435|rcsb pdb:6Y5Q|rcsb pdb:7ABG|rcsb pdb:7ABH|rcsb pdb:7ABI|rcsb pdb:7DVQ|reactome:R-HSA-72163|reactome:R-HSA-72165	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606	rogid:Y9uCV2x4J5kqyxeO8iXjojkXocA9606	rigid:GFsCc5m9fIfvpTt3tQqhin6mIlA	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51116	uniprotkb:Q96GD3	intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113	intact:EBI-713793|uniprotkb:Q5VT76|uniprotkb:Q6IAJ4|uniprotkb:Q8WU48|uniprotkb:Q9UKM5|uniprotkb:Q9UKM6|ensembl:ENSP00000318094|ensembl:ENSP00000380359|uniprotkb:B4DRQ8	psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym)	psi-mi:scmh1_human(display_long)|uniprotkb:Sex comb on midleg homolog 1(gene name synonym)|uniprotkb:SCMH1(gene name)|psi-mi:SCMH1(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512183|imex:IM-28561-1203	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z	refseq:XP_006710527.1|ensembl:ENSG00000010803(gene)|ensembl:ENST00000326197(transcript)|ensembl:ENST00000397174(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0007283"(spermatogenesis)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010369"(chromocenter)|go:"GO:0016458"(obsolete gene silencing)|go:"GO:0042393"(histone binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR004092(Mbt repeat)|interpro:IPR013761(Sterile alpha motif-type)|go:"GO:0005634"(nucleus)|interpro:IPR021987|interpro:IPR033763|interpro:IPR038348|mint:Q96GD3|rcsb pdb:2P0K|reactome:R-HSA-2559580|reactome:R-HSA-3108214|reactome:R-HSA-3899300|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4655427|reactome:R-HSA-8939243|reactome:R-HSA-8943724|refseq:NP_001026864.1|refseq:NP_001165689.1|refseq:NP_001165690.1|refseq:NP_001165691.1|refseq:NP_001165692.1|refseq:NP_001165693.1|refseq:NP_036368.1|refseq:XP_016856188.1|refseq:XP_016856196.1|refseq:XP_011539335.1|refseq:XP_011539338.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606	rogid:e39O++wYwPAUlKUeNfRurqnXbz09606	rigid:9h6bI3jzPbZa9qYLCRS4yD5hIx0	false	sufficient binding region:235-370	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51116	uniprotkb:O43609	intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113	intact:EBI-3866665|uniprotkb:Q6PNE0|uniprotkb:D3DNX6|ensembl:ENSP00000343785|ensembl:ENSP00000377871|ensembl:ENSP00000480540|ensembl:ENSP00000481675|ensembl:ENSP00000498292	psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym)	psi-mi:spy1_human(display_long)|uniprotkb:SPRY1(gene name)|psi-mi:SPRY1(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512208|imex:IM-28561-773	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z	refseq:NP_005832.1|refseq:NP_955359.1|refseq:NP_001244967.1|refseq:NP_001244968.1|refseq:XP_005262743.1|ensembl:ENSG00000164056(gene)|ensembl:ENST00000339241(transcript)|ensembl:ENST00000394339(transcript)|ensembl:ENST00000610581(transcript)|ensembl:ENST00000622283(transcript)|ensembl:ENST00000651917(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0001656"(metanephros development)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001759"(organ induction)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048513"(animal organ development)|go:"GO:0051387"(negative regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0060449"(bud elongation involved in lung branching)|go:"GO:0060940"(epithelial to mesenchymal transition involved in cardiac fibroblast development)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:1902747"(negative regulation of lens fiber cell differentiation)|interpro:IPR007875(Sprouty)|interpro:IPR030783|mint:O43609|reactome:R-HSA-182971|refseq:XP_016863124.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606	rogid:tbucIEQYibDQbBC1xVIZVDH2nIY9606	rigid:zQlPL8dVHmEZ3hs2rMkLgOABnlo	false	sufficient binding region:235-370	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51116	uniprotkb:O43597	intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113	intact:EBI-742487|uniprotkb:Q5T6Z7|ensembl:ENSP00000366306|ensembl:ENSP00000366308|uniprotkb:B2R9J9	psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym)	psi-mi:spy2_human(display_long)|uniprotkb:SPRY2(gene name)|psi-mi:SPRY2(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512217|imex:IM-28561-569	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z	refseq:NP_005833.1|rcsb pdb:5HL0|reactome:R-HSA-1295596|reactome:R-HSA-182971|rcsb pdb:5HKZ|ensembl:ENST00000377102(transcript)|ensembl:ENST00000377104(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|ensembl:ENSG00000136158(gene)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030291"(protein serine/threonine kinase inhibitor activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031345"(negative regulation of cell projection organization)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045165"(cell fate commitment)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048513"(animal organ development)|go:"GO:0051387"(negative regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060437"(lung growth)|go:"GO:0060449"(bud elongation involved in lung branching)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:1900747"(negative regulation of vascular endothelial growth factor signaling pathway)|go:"GO:1902747"(negative regulation of lens fiber cell differentiation)|go:"GO:1990752"(microtubule end)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR007875(Sprouty)|interpro:IPR030780|mint:O43597|rcsb pdb:3BUM|rcsb pdb:3OB1|rcsb pdb:5HKY|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|refseq:NP_001305465.1|refseq:NP_001305466.1|refseq:NP_001305467.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606	rogid:u1omauzisc6MdZlogMotUmtauSI9606	rigid:ugupmUASg11CSmMWlzPSPWKOA58	false	sufficient binding region:235-370	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51116	uniprotkb:Q12800	intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113	intact:EBI-717422|uniprotkb:Q12801|uniprotkb:Q9UD77|uniprotkb:A8K5E9|uniprotkb:Q9UD75|ensembl:ENSP00000257915	psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym)	psi-mi:tfcp2_human(display_long)|uniprotkb:Transcription factor LSF(gene name synonym)|uniprotkb:SAA3 enhancer factor(gene name synonym)|uniprotkb:TFCP2(gene name)|psi-mi:TFCP2(display_short)|uniprotkb:LSF(gene name synonym)|uniprotkb:SEF(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512226|imex:IM-28561-991	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z	refseq:NP_001166923.1|refseq:NP_001166924.1|refseq:NP_005644.2|ensembl:ENSG00000135457(gene)|ensembl:ENST00000257915(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR007604(CP2 transcription factor)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR037599|interpro:IPR041418|mint:Q12800	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606	rogid:M7mQ08NDYxuawmUEKRgjSdIr+Og9606	rigid:UZ17F08m7jfL2z/ZxfNBHiqgswc	false	sufficient binding region:235-370	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51116	uniprotkb:Q13829	intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113	intact:EBI-2505861|uniprotkb:B7Z6M4|uniprotkb:Q5TZQ1|ensembl:ENSP00000226225	psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym)	psi-mi:bacd2_human(display_long)|uniprotkb:BACURD2(gene name synonym)|uniprotkb:BTB/POZ domain-containing protein TNFAIP1(gene name synonym)|uniprotkb:Protein B12(gene name synonym)|uniprotkb:TNFAIP1(gene name)|psi-mi:TNFAIP1(display_short)|uniprotkb:EDP1(gene name synonym)|uniprotkb:Tumor necrosis factor, alpha-induced protein 1, endothelial(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512235|imex:IM-28561-331	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z	refseq:NP_066960.1|ensembl:ENSG00000109079(gene)|ensembl:ENST00000226225(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006955"(immune response)|go:"GO:0016477"(cell migration)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030332"(cyclin binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0051260"(protein homooligomerization)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR003131(Potassium channel, voltage dependent, Kv,  tetramerisation)|interpro:IPR011333(BTB/POZ fold)|mint:Q13829|reactome:R-HSA-9696264|reactome:R-HSA-9696270	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606	rogid:8vM9HnNmkirDbJRETV/TeE8pONY9606	rigid:7/UwoYhyMhEUB+uEWwDN4pFSSWE	false	sufficient binding region:235-370	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51116	uniprotkb:Q8NFZ5	intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113	intact:EBI-359372|uniprotkb:Q7L5L2|uniprotkb:Q9BQR6|uniprotkb:Q9H682|uniprotkb:B1AKS4|uniprotkb:B3KTY8|uniprotkb:D3DVQ9|ensembl:ENSP00000321203	psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym)	psi-mi:tnip2_human(display_long)|uniprotkb:TNIP2(gene name)|psi-mi:TNIP2(display_short)|uniprotkb:ABIN2(gene name synonym)|uniprotkb:FLIP1(gene name synonym)|uniprotkb:Fetal liver LKB1-interacting protein(gene name synonym)|uniprotkb:A20-binding inhibitor of NF-kappa-B activation 2(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512244|imex:IM-28561-993	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z	refseq:NP_001154999.1|refseq:NP_077285.3|ensembl:ENSG00000168884(gene)|ensembl:ENST00000315423(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR022008|interpro:IPR034735|mint:Q8NFZ5|rcsb pdb:5H07|reactome:R-HSA-5684264|reactome:R-HSA-5689896|refseq:NP_001278945.1|dip:DIP-27617N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606	rogid:K9Ee06++lTFEHy1d/3tMu6uwyU09606	rigid:pj4/WgZubSfnEmqDGG9a0O2x4po	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51116	uniprotkb:Q12933	intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113	intact:EBI-355744|uniprotkb:Q96NT2|uniprotkb:A8K107|uniprotkb:B4DPJ7|uniprotkb:Q7Z337|intact:EBI-1046651|ensembl:ENSP00000247668	psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym)	psi-mi:traf2_human(display_long)|uniprotkb:TRAF2(gene name)|psi-mi:TRAF2(display_short)|uniprotkb:TRAP3(gene name synonym)|uniprotkb:Tumor necrosis factor type 2 receptor-associated protein 3(gene name synonym)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512251|imex:IM-28561-995	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z	refseq:NP_066961.2|refseq:XP_011517279.1|refseq:XP_011517280.1|refseq:XP_011517276.1|refseq:XP_011517277.1|refseq:XP_011517278.1|ensembl:ENSG00000127191(gene)|ensembl:ENST00000247668(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005174"(CD40 receptor binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034622"|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027133|interpro:IPR032070|interpro:IPR037305|interpro:IPR043211|mint:Q12933|rcsb pdb:1CA4|rcsb pdb:1CA9|rcsb pdb:1CZY|rcsb pdb:1CZZ|rcsb pdb:1D00|rcsb pdb:1D01|rcsb pdb:1D0A|rcsb pdb:1D0J|rcsb pdb:1F3V|rcsb pdb:1QSC|rcsb pdb:3KNV|rcsb pdb:3M06|rcsb pdb:3M0A|rcsb pdb:3M0D|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5668541|reactome:R-HSA-5675482|reactome:R-HSA-5676594|reactome:R-HSA-5689880|reactome:R-HSA-69416|reactome:R-HSA-75893|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-9693928|refseq:XP_016870584.1|dip:DIP-6223N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606	rogid:JhaoM5kRLh3zwhXr+BsCCRNOYa09606	rigid:Pbt1lpXe4cyaU3HRmmO7ck1t4l4	false	sufficient binding region:235-370	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51116	uniprotkb:O75382	intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113	intact:EBI-2129889|uniprotkb:Q4V9L4|uniprotkb:Q9C038|uniprotkb:Q9C039|uniprotkb:B7Z5E6|uniprotkb:F5H2Q8|ensembl:ENSP00000340797|ensembl:ENSP00000352508|ensembl:ENSP00000433102	psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym)	psi-mi:trim3_human(display_long)|uniprotkb:TRIM3(gene name)|psi-mi:TRIM3(display_short)|uniprotkb:BERP(gene name synonym)|uniprotkb:RNF22(gene name synonym)|uniprotkb:RNF97(gene name synonym)|uniprotkb:RING finger protein 22(gene name synonym)|uniprotkb:Brain-expressed RING finger protein(gene name synonym)|uniprotkb:RING finger protein 97(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512260|imex:IM-28561-775	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z	refseq:XP_011518146.1|refseq:XP_011518147.1|refseq:NP_006449.2|refseq:NP_150594.2|refseq:XP_016872587.1|refseq:XP_016872588.1|refseq:NP_001234935.1|refseq:NP_001234936.1|ensembl:ENSG00000110171(gene)|ensembl:ENST00000345851(transcript)|ensembl:ENST00000359518(transcript)|ensembl:ENST00000525074(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0007399"(nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015031"(protein transport)|go:"GO:0030425"(dendrite)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001258(NHL repeat)|interpro:IPR001298(Filamin/ABP280 repeat)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003649(B-box, C-terminal)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR013017(NHL repeat, subgroup)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR017907|interpro:IPR027370|mint:O75382|reactome:R-HSA-877300	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606	rogid:Vz2XqDSJXAWxxubxtghV91m9K009606	rigid:wnTuN1qht6E14ddOuaqQcop615o	false	sufficient binding region:235-370	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51116	uniprotkb:Q9H2D6	intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113	intact:EBI-715619|uniprotkb:B1AHD4|uniprotkb:B1AHD7|uniprotkb:O94797|uniprotkb:Q2PZW8|uniprotkb:Q2Q3Z9|uniprotkb:Q2Q400|uniprotkb:Q5R3M6|uniprotkb:Q96DW1|uniprotkb:Q9BT77|uniprotkb:Q9BTL7|uniprotkb:Q9BY98|uniprotkb:Q9Y3L4|ensembl:ENSP00000496394|intact:EBI-2560917|uniprotkb:F2Z2W0|uniprotkb:F8W6V6	psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym)	psi-mi:tara_human(display_long)|uniprotkb:Protein Tara(gene name synonym)|uniprotkb:Trio-associated repeat on actin(gene name synonym)|uniprotkb:TRIOBP(gene name)|psi-mi:TRIOBP(display_short)|uniprotkb:KIAA1662(gene name synonym)|uniprotkb:TARA(gene name synonym)|uniprotkb:HRIHFB2122(orf name)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512269|imex:IM-28561-1479	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z	refseq:NP_001034230.1|refseq:NP_008963.3|refseq:NP_619538.2|ensembl:ENSG00000100106(gene)|ensembl:ENST00000644935(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0007049"(cell cycle)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030047"(actin modification)|go:"GO:0030496"(midbody)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0045159"(myosin II binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0051016"(barbed-end actin filament capping)|go:"GO:0051301"(cell division)|go:"GO:0060088"(auditory receptor cell stereocilium organization)|go:"GO:0120044"(stereocilium base)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039597|mint:Q9H2D6|reactome:R-HSA-9662360|reactome:R-HSA-9662361|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606	rogid:2evioSQxAnH1x5VPGsZyK+fJTY09606	rigid:uaRyXVv4UMeFggDAmJHWn1s1uTA	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51116	uniprotkb:P08670	intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113	intact:EBI-353844|uniprotkb:Q15867|uniprotkb:Q15868|uniprotkb:Q15869|uniprotkb:Q548L2|uniprotkb:Q6LER9|uniprotkb:Q8N850|uniprotkb:Q96ML2|uniprotkb:Q9NTM3|uniprotkb:B0YJC2|intact:EBI-3442369|uniprotkb:D3DRU4|ensembl:ENSP00000224237|ensembl:ENSP00000446007	psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym)	psi-mi:vime_human(display_long)|uniprotkb:VIM(gene name)|psi-mi:VIM(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512276|imex:IM-28561-571	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z	refseq:NP_003371.2|ensembl:ENSG00000026025(gene)|ensembl:ENST00000224237(transcript)|ensembl:ENST00000544301(transcript)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005212"(structural constituent of eye lens)|go:"GO:0005737"(cytoplasm)|go:"GO:0005777"(peroxisome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014002"(astrocyte development)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031252"(cell leading edge)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0070307"(lens fiber cell development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071225"(cellular response to muramyl dipeptide)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1990254"(keratin filament binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|interpro:IPR027699|interpro:IPR039008|mint:P08670|rcsb pdb:1GK4|rcsb pdb:1GK6|rcsb pdb:1GK7|rcsb pdb:3G1E|rcsb pdb:3KLT|rcsb pdb:3S4R|rcsb pdb:3SSU|rcsb pdb:3SWK|rcsb pdb:3TRT|rcsb pdb:3UF1|rcsb pdb:4MCY|rcsb pdb:4MCZ|rcsb pdb:4MD0|rcsb pdb:4MD5|rcsb pdb:4MDI|rcsb pdb:4MDJ|rcsb pdb:4YPC|rcsb pdb:4YV3|rcsb pdb:5WHF|rcsb pdb:6ATF|rcsb pdb:6ATI|rcsb pdb:6BIR|rcsb pdb:6YXK|reactome:R-HSA-264870|reactome:R-HSA-390522|reactome:R-HSA-6785807|reactome:R-HSA-9013422|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9646399|refseq:XP_006717563.1|dip:DIP-32507N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606	rogid:GhAhVuXMNxi6P5J0CfNi5l9bjRk9606	rigid:TIUzN3WdA/MwN91SJ+DZT9dE8s8	false	sufficient binding region:235-370	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51116	uniprotkb:Q6PJI9	intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113	intact:EBI-2515073|intact:EBI-28967178|ensembl:ENSP00000262144|uniprotkb:Q9HA43|uniprotkb:Q96PW5|uniprotkb:B3KRC3|uniprotkb:Q9BSW6|uniprotkb:Q71RE7	psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym)	psi-mi:wdr59_human(display_long)|uniprotkb:WDR59(gene name)|psi-mi:WDR59(display_short)|uniprotkb:KIAA1923(gene name synonym)|uniprotkb:WD repeat-containing protein 59(gene name synonym)|uniprotkb:FP977(orf name)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512285|imex:IM-28561-1481	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z	ensembl:ENSP00000262144|ensembl:ENST00000616369|ensembl:ENSP00000482446|ensembl:ENSG00000103091(gene)|ensembl:ENST00000262144(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR006575(RWD)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR039456|reactome:R-HSA-9639288|mint:Q6PJI9|refseq:NP_001311100.1|refseq:NP_085058.3	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606	rogid:7yMOhbv8kjVuL8I+Zs+8fLF933k9606	rigid:fovGMChn/lNfFBA83SDiksik3UU	false	sufficient binding region:235-370	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51116	uniprotkb:P23246	intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113	intact:EBI-355453|uniprotkb:P30808|uniprotkb:Q5SZ71|ensembl:ENSP00000349748	psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym)	psi-mi:sfpq_human(display_long)|uniprotkb:SFPQ(gene name)|psi-mi:SFPQ(display_short)|uniprotkb:PSF(gene name synonym)|uniprotkb:Polypyrimidine tract-binding protein-associated-splicing factor(gene name synonym)|uniprotkb:DNA-binding p52/p100 complex, 100 kDa subunit(gene name synonym)|uniprotkb:100 kDa DNA-pairing protein(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512199|imex:IM-28561-567	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z	refseq:NP_005057.1|ensembl:ENSG00000116560(gene)|ensembl:ENST00000357214(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0016363"(nuclear matrix)|go:"GO:0003723"(RNA binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0042382"(paraspeckles)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0005634"(nucleus)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045876"(positive regulation of sister chromatid cohesion)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0048511"(rhythmic process)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0098963"(dendritic transport of messenger ribonucleoprotein complex)|go:"GO:1902177"(positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:0006355"(regulation of transcription, DNA-templated)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR012975(NOPS)|interpro:IPR034525|interpro:IPR034526|interpro:IPR035979|mint:P23246|rcsb pdb:4WII|rcsb pdb:4WIJ|rcsb pdb:4WIK|rcsb pdb:5WPA|rcsb pdb:6NCQ|rcsb pdb:6OWJ|rcsb pdb:6WMZ|rcsb pdb:7LRQ|rcsb pdb:7LRU|reactome:R-HSA-8849468|reactome:R-HSA-9635465|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|refseq:XP_005271169.1|refseq:XP_005271170.1|refseq:XP_005271172.1|refseq:XP_016857542.1|refseq:XP_016857543.1|dip:DIP-31272N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606	rogid:B7mSc6tthLbSHo0qz0SMZBSl3HA9606	rigid:sU1+Deq551m8I7xiSyBC3CfxpXk	false	sufficient binding region:235-370	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51116	uniprotkb:Q9ULU4	intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113	intact:EBI-765834|uniprotkb:Q13517|uniprotkb:Q4JJ94|uniprotkb:Q4JJ95|uniprotkb:Q5TH09|uniprotkb:Q6MZM1|uniprotkb:Q8WXC5|uniprotkb:Q9H1F3|uniprotkb:Q9H1F4|uniprotkb:Q9H1F5|uniprotkb:Q9H1L8|uniprotkb:Q9H1L9|uniprotkb:Q9H2G5|uniprotkb:Q9NYN3|uniprotkb:Q9UIX6|uniprotkb:Q2HXV7|uniprotkb:E1P5U5|uniprotkb:B7Z680|uniprotkb:Q2HXV2|uniprotkb:Q2HXV8|uniprotkb:Q2HXW0|uniprotkb:Q2HXW1|uniprotkb:Q2HXW2|uniprotkb:Q2HXV4|uniprotkb:Q2HXV9|uniprotkb:B3KVL2|uniprotkb:B7Z2A8|uniprotkb:B7Z3E0|uniprotkb:B7ZM62|uniprotkb:F5H0X3|uniprotkb:H7C0U2|uniprotkb:J3KPU3|uniprotkb:Q2HXV1|uniprotkb:Q2HXV3|uniprotkb:Q5TH11|ensembl:ENSP00000312237	psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym)	psi-mi:pkcb1_human(display_long)|uniprotkb:Rack7(gene name synonym)|uniprotkb:Cutaneous T-cell lymphoma-associated antigen se14-3(gene name synonym)|uniprotkb:Zinc finger MYND domain-containing protein 8(gene name synonym)|uniprotkb:ZMYND8(gene name)|psi-mi:ZMYND8(display_short)|uniprotkb:KIAA1125(gene name synonym)|uniprotkb:RACK7(gene name synonym)|uniprotkb:PRKCBP1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512303|imex:IM-28561-333	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z	refseq:NP_036540.3|refseq:NP_898868.1|refseq:NP_898869.1|refseq:XP_011527053.1|refseq:NP_001268711.1|refseq:NP_001268706.1|refseq:NP_001268710.1|ensembl:ENST00000262975|ensembl:ENSP00000262975|ensembl:ENSP00000312237|ensembl:ENST00000352431|ensembl:ENSP00000335537|ensembl:ENST00000355972|ensembl:ENSP00000348246|ensembl:ENST00000360911|ensembl:ENSP00000354166|ensembl:ENST00000372023|ensembl:ENSP00000361093|ensembl:ENST00000396281|ensembl:ENSP00000379577|refseq:NP_001268702.1|refseq:NP_001268703.1|refseq:NP_001268704.1|refseq:NP_001268705.1|refseq:NP_001268707.1|refseq:NP_001268712.1|refseq:XP_005260417.1|refseq:XP_005260423.1|ensembl:ENST00000446994|ensembl:ENSP00000396725|ensembl:ENST00000458360|ensembl:ENSP00000392964|ensembl:ENST00000461685|ensembl:ENSP00000418210|ensembl:ENST00000471951|ensembl:ENSP00000420095|ensembl:ENST00000536340|ensembl:ENSP00000439800|ensembl:ENST00000540497|ensembl:ENSP00000443086|refseq:NP_001268713.1|refseq:XP_005260413.1|refseq:NP_001268700.1|refseq:NP_001268701.1|refseq:XP_006723825.1|refseq:XP_016883250.1|refseq:XP_016883256.1|refseq:XP_016883257.1|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0035064"(methylated histone binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:0098815"(modulation of excitatory postsynaptic potential)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902897"(regulation of postsynaptic density protein 95 clustering)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|interpro:IPR000313(PWWP)|interpro:IPR001487(Bromodomain)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002893(Zinc finger, MYND-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR021931|interpro:IPR035505|interpro:IPR036427|interpro:IPR037967|interpro:IPR044075|mint:Q9ULU4|rcsb pdb:4COS|rcsb pdb:5B73|rcsb pdb:5MQ4|go:"GO:0005654"(nucleoplasm)|rcsb pdb:5Y1Z|ensembl:ENSG00000101040(gene)|ensembl:ENST00000311275(transcript)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606	rogid:z46jFcDnmKauE75GMeApPZmfdDM9606	rigid:ocNYXM6n+tV9jrB8Q5lyfaztwaU	false	sufficient binding region:235-370	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49639	uniprotkb:O00154	intact:EBI-740785|uniprotkb:O43363|uniprotkb:B2R8U7|uniprotkb:A4D184	intact:EBI-948905|ensembl:ENSP00000367086|uniprotkb:O43703|uniprotkb:Q53Y78|uniprotkb:Q5JYL2|uniprotkb:Q5JYL3|uniprotkb:Q5JYL4|uniprotkb:Q5JYL5|uniprotkb:Q5JYL6|uniprotkb:Q5TGR4|uniprotkb:Q9UJM9|uniprotkb:Q9Y539|uniprotkb:Q9Y540|uniprotkb:A8K0K7|uniprotkb:A8K232|uniprotkb:A8K6B8|uniprotkb:A8K837|uniprotkb:B3KQ12	psi-mi:hxa1_human(display_long)|uniprotkb:Homeobox protein Hox-1F(gene name synonym)|uniprotkb:HOXA1(gene name)|psi-mi:HOXA1(display_short)|uniprotkb:HOX1F(gene name synonym)	psi-mi:bach_human(display_long)|uniprotkb:Long chain acyl-CoA thioester hydrolase(gene name synonym)|uniprotkb:Acyl-CoA thioesterase 7(gene name synonym)|uniprotkb:CTE-IIa(gene name synonym)|uniprotkb:Brain acyl-CoA hydrolase(gene name synonym)|uniprotkb:BACH(gene name synonym)|uniprotkb:ACOT7(gene name)|psi-mi:ACOT7(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512312|imex:IM-28561-335	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005513.1|refseq:NP_705873.2|interpro:IPR001356(Homeobox)|interpro:IPR017970|interpro:IPR020479|interpro:IPR009057(Homeodomain-like)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007634"(optokinetic behavior)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0021599"(abducens nerve formation)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048702"(embryonic neurocranium morphogenesis)|go:"GO:0048839"(inner ear development)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050795"(regulation of behavior)|go:"GO:0050890"(cognition)|go:"GO:0050905"(neuromuscular process)|go:"GO:0060840"(artery development)|go:"GO:0060876"(semicircular canal formation)|go:"GO:0090102"(cochlea development)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|reactome:R-HSA-5617472|mint:P49639	go:"GO:0051792"(medium-chain fatty acid biosynthetic process)|go:"GO:0052689"(carboxylic ester hydrolase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0102991"(myristoyl-CoA hydrolase activity)|go:"GO:1900535"(palmitic acid biosynthetic process)|interpro:IPR006683(Thioesterase superfamily)|interpro:IPR029069|interpro:IPR033120|interpro:IPR040170|mint:O00154|rcsb pdb:2QQ2|reactome:R-HSA-77289|go:"GO:0047617"(acyl-CoA hydrolase activity)|ensembl:ENSG00000097021(gene)|ensembl:ENST00000377855(transcript)|go:"GO:0000062"(fatty-acyl-CoA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006637"(acyl-CoA metabolic process)|go:"GO:0015937"(coenzyme A biosynthetic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0036042"(long-chain fatty acyl-CoA binding)|go:"GO:0036114"(medium-chain fatty-acyl-CoA catabolic process)|go:"GO:0036116"(long-chain fatty-acyl-CoA catabolic process)|go:"GO:0042803"(protein homodimerization activity)|refseq:NP_863655.1|refseq:NP_863656.1|refseq:NP_009205.3|refseq:NP_863654.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:QjQVU0uonSpj5vQU0pgzXuXmW3Y9606	rogid:Tv8nHSqfXMmzZqj71+Gec6+29/s9606	rigid:ABklNRROM8fpDqovbkwDAuaiDOc	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49639	uniprotkb:O43184	intact:EBI-740785|uniprotkb:O43363|uniprotkb:B2R8U7|uniprotkb:A4D184	intact:EBI-2625825|uniprotkb:O60470|uniprotkb:Q5JRP0|uniprotkb:Q5JRP1|uniprotkb:Q6P9E3|uniprotkb:Q6UWB0|ensembl:ENSP00000357668	psi-mi:hxa1_human(display_long)|uniprotkb:Homeobox protein Hox-1F(gene name synonym)|uniprotkb:HOXA1(gene name)|psi-mi:HOXA1(display_short)|uniprotkb:HOX1F(gene name synonym)	psi-mi:ada12_human(display_long)|uniprotkb:ADAM12(gene name)|psi-mi:ADAM12(display_short)|uniprotkb:MLTN(gene name synonym)|uniprotkb:Meltrin-alpha(gene name synonym)|uniprotkb:UNQ346/PRO545(orf name)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512319|imex:IM-28561-573	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005513.1|refseq:NP_705873.2|interpro:IPR001356(Homeobox)|interpro:IPR017970|interpro:IPR020479|interpro:IPR009057(Homeodomain-like)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007634"(optokinetic behavior)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0021599"(abducens nerve formation)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048702"(embryonic neurocranium morphogenesis)|go:"GO:0048839"(inner ear development)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050795"(regulation of behavior)|go:"GO:0050890"(cognition)|go:"GO:0050905"(neuromuscular process)|go:"GO:0060840"(artery development)|go:"GO:0060876"(semicircular canal formation)|go:"GO:0090102"(cochlea development)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|reactome:R-HSA-5617472|mint:P49639	refseq:NP_003465.3|refseq:NP_067673.2|refseq:NP_001275903.1|refseq:NP_001275904.1|ensembl:ENSG00000148848(gene)|ensembl:ENST00000368679(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007520"(myoblast fusion)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046872"(metal ion binding)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR006586(ADAM, cysteine-rich)|interpro:IPR018358|interpro:IPR024079|interpro:IPR034027|interpro:IPR036436|mint:O43184|reactome:R-HSA-177929|reactome:R-HSA-8941237	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:QjQVU0uonSpj5vQU0pgzXuXmW3Y9606	rogid:BxY61EDGsWcXVsb7i8+zzf7Q12c9606	rigid:17yk2mkLdlisW3gHzAyhUvl5zqc	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49639	uniprotkb:Q86TH1	intact:EBI-740785|uniprotkb:O43363|uniprotkb:B2R8U7|uniprotkb:A4D184	intact:EBI-3929531|uniprotkb:O60345|uniprotkb:B1B0D5|ensembl:ENSP00000346478|ensembl:ENSP00000376780|ensembl:ENSP00000498961	psi-mi:hxa1_human(display_long)|uniprotkb:Homeobox protein Hox-1F(gene name synonym)|uniprotkb:HOXA1(gene name)|psi-mi:HOXA1(display_short)|uniprotkb:HOX1F(gene name synonym)	psi-mi:atl2_human(display_long)|uniprotkb:ADAMTSL2(gene name)|psi-mi:ADAMTSL2(display_short)|uniprotkb:KIAA0605(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512326|imex:IM-28561-337	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005513.1|refseq:NP_705873.2|interpro:IPR001356(Homeobox)|interpro:IPR017970|interpro:IPR020479|interpro:IPR009057(Homeodomain-like)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007634"(optokinetic behavior)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0021599"(abducens nerve formation)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048702"(embryonic neurocranium morphogenesis)|go:"GO:0048839"(inner ear development)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050795"(regulation of behavior)|go:"GO:0050890"(cognition)|go:"GO:0050905"(neuromuscular process)|go:"GO:0060840"(artery development)|go:"GO:0060876"(semicircular canal formation)|go:"GO:0090102"(cochlea development)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|reactome:R-HSA-5617472|mint:P49639	ensembl:ENSG00000197859(gene)|ensembl:ENST00000354484(transcript)|ensembl:ENST00000393060(transcript)|ensembl:ENST00000651351(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031012"(extracellular matrix)|go:"GO:0050436"(microfibril binding)|go:"GO:0060481"(lobar bronchus epithelium development)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR010294(ADAM-TS Spacer 1)|interpro:IPR010909(PLAC)|interpro:IPR013273(Peptidase M12B, ADAM-TS)|interpro:IPR036383|reactome:R-HSA-5083635|reactome:R-HSA-5173214|mint:Q86TH1|refseq:NP_001138792.1|refseq:NP_055509.2|refseq:XP_005272296.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:QjQVU0uonSpj5vQU0pgzXuXmW3Y9606	rogid:eXpVsBE5nivzPtClNJpBJ8Wmd4Y9606	rigid:e5toz/vJqBBRupOYNSb7ujzpY9Y	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49639	uniprotkb:Q96P47	intact:EBI-740785|uniprotkb:O43363|uniprotkb:B2R8U7|uniprotkb:A4D184	intact:EBI-6873422|uniprotkb:Q96RK3|uniprotkb:Q59EN0|uniprotkb:B3KNZ8|uniprotkb:E9PAL8|ensembl:ENSP00000480655	psi-mi:hxa1_human(display_long)|uniprotkb:Homeobox protein Hox-1F(gene name synonym)|uniprotkb:HOXA1(gene name)|psi-mi:HOXA1(display_short)|uniprotkb:HOX1F(gene name synonym)	psi-mi:agap3_human(display_long)|uniprotkb:CENTG3(gene name synonym)|uniprotkb:CRAM-associated GTPase(gene name synonym)|uniprotkb:Centaurin-gamma-3(gene name synonym)|uniprotkb:MR1-interacting protein(gene name synonym)|uniprotkb:AGAP3(gene name)|psi-mi:AGAP3(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512333|imex:IM-28561-575	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005513.1|refseq:NP_705873.2|interpro:IPR001356(Homeobox)|interpro:IPR017970|interpro:IPR020479|interpro:IPR009057(Homeodomain-like)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007634"(optokinetic behavior)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0021599"(abducens nerve formation)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048702"(embryonic neurocranium morphogenesis)|go:"GO:0048839"(inner ear development)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050795"(regulation of behavior)|go:"GO:0050890"(cognition)|go:"GO:0050905"(neuromuscular process)|go:"GO:0060840"(artery development)|go:"GO:0060876"(semicircular canal formation)|go:"GO:0090102"(cochlea development)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|reactome:R-HSA-5617472|mint:P49639	refseq:NP_001268229.1|refseq:XP_016867223.1|refseq:NP_114152.3|refseq:NP_001036000.1|ensembl:ENSG00000133612(gene)|ensembl:ENST00000622464(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0071944"(cell periphery)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR001806(Ras GTPase)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002110(Ankyrin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR020683|interpro:IPR027417|interpro:IPR036770|interpro:IPR037278|interpro:IPR038508|mint:Q96P47|rcsb pdb:3IHW	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:QjQVU0uonSpj5vQU0pgzXuXmW3Y9606	rogid:kfyXrwC5SFjflXEMQ2wfKoB98Ig9606	rigid:DiN3R1NAar3eHbtBSCU23iSmiG0	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49639	uniprotkb:O00468	intact:EBI-740785|uniprotkb:O43363|uniprotkb:B2R8U7|uniprotkb:A4D184	intact:EBI-947482|uniprotkb:Q5SVA2|uniprotkb:Q60FE1|uniprotkb:Q7KYS8|uniprotkb:Q8N4J5|uniprotkb:Q96IC1|uniprotkb:Q9BTD4|uniprotkb:Q5SVA1	psi-mi:hxa1_human(display_long)|uniprotkb:Homeobox protein Hox-1F(gene name synonym)|uniprotkb:HOXA1(gene name)|psi-mi:HOXA1(display_short)|uniprotkb:HOX1F(gene name synonym)	psi-mi:agrin_human(display_long)|uniprotkb:AGRN(gene name)|psi-mi:AGRN(display_short)|uniprotkb:AGRIN(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512340|imex:IM-28561-1691	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005513.1|refseq:NP_705873.2|interpro:IPR001356(Homeobox)|interpro:IPR017970|interpro:IPR020479|interpro:IPR009057(Homeodomain-like)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007634"(optokinetic behavior)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0021599"(abducens nerve formation)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048702"(embryonic neurocranium morphogenesis)|go:"GO:0048839"(inner ear development)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050795"(regulation of behavior)|go:"GO:0050890"(cognition)|go:"GO:0050905"(neuromuscular process)|go:"GO:0060840"(artery development)|go:"GO:0060876"(semicircular canal formation)|go:"GO:0090102"(cochlea development)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|reactome:R-HSA-5617472|mint:P49639	refseq:NP_940978.2|interpro:IPR004850(Agrin NtA)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002049(EGF-like, laminin)|interpro:IPR003645(Follistatin-like, N-terminal)|interpro:IPR001791(Laminin G)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR000082(SEA)|interpro:IPR008993(TIMP-like, OB-fold)|refseq:XP_005244806.1|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR003884(Factor I membrane attack complex)|mint:O00468|go:"GO:0002162"(dystroglycan binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009888"(tissue development)|go:"GO:0016021"(integral component of membrane)|go:"GO:0033691"(sialic acid binding)|go:"GO:0035374"(chondroitin sulfate binding)|go:"GO:0043113"(receptor clustering)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043236"(laminin binding)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045162"(clustering of voltage-gated sodium channels)|go:"GO:0045202"(synapse)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050808"(synapse organization)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|reactome:R-HSA-1971475|reactome:R-HSA-2022928|reactome:R-HSA-2024096|reactome:R-HSA-216083|reactome:R-HSA-3000171|reactome:R-HSA-3000178|reactome:R-HSA-3560783|reactome:R-HSA-3560801|reactome:R-HSA-3656237|reactome:R-HSA-3656253|reactome:R-HSA-419037|reactome:R-HSA-4420332|reactome:R-HSA-975634|interpro:IPR036058|interpro:IPR036364|refseq:NP_001292204.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:QjQVU0uonSpj5vQU0pgzXuXmW3Y9606	rogid:LRk4v4aYLk5kep9EIbjjiCGM7OM9606	rigid:UKY7w+ljhuE06Kj7qo8FivjcLrc	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51116	uniprotkb:Q5TAX3	intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113	intact:EBI-1606413|uniprotkb:Q12764|uniprotkb:Q5TAX4|uniprotkb:Q86XZ3|uniprotkb:D3DQ35|uniprotkb:A2RRP0|uniprotkb:B7Z8J5|uniprotkb:Q5TAX2|intact:EBI-2841402|ensembl:ENSP00000360599	psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym)	psi-mi:tut4_human(display_long)|uniprotkb:TUT4(gene name)|psi-mi:TUT4(display_short)|uniprotkb:KIAA0191(gene name synonym)|uniprotkb:ZCCHC11(gene name synonym)|uniprotkb:Zinc finger CCHC domain-containing protein 11(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512296|imex:IM-28561-1689	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z	refseq:NP_001009881.1|refseq:NP_056084.1|ensembl:ENST00000371544(transcript)|go:"GO:0000289"("nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0001556"(oocyte maturation)|go:"GO:0003723"(RNA binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010526"(negative regulation of transposition, RNA-mediated)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010587"(miRNA catabolic process)|go:"GO:0016779"(nucleotidyltransferase activity)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0031123"(RNA 3'-end processing)|go:"GO:0035198"(miRNA binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0050265"(RNA uridylyltransferase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071076"(RNA 3' uridylation)|go:"GO:1990074"(polyuridylation-dependent mRNA catabolic process)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR002058(PAP/25A-associated)|interpro:IPR036875|interpro:IPR043519|mint:Q5TAX3|rcsb pdb:6IW6|reactome:R-HSA-429947|ensembl:ENSG00000134744(gene)	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606	rogid:tjwo/S3PJ2jrLAKL9gt7muDTO0w9606	rigid:1nhTssyxsNsbT6VQMIOE1mYEqPY	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49639	uniprotkb:Q9UBP4	intact:EBI-740785|uniprotkb:O43363|uniprotkb:B2R8U7|uniprotkb:A4D184	intact:EBI-954409|ensembl:ENSP00000314910|ensembl:ENSP00000379762|ensembl:ENSP00000506835|uniprotkb:Q9ULB7|uniprotkb:A8K1I2|uniprotkb:D3DQW1	psi-mi:hxa1_human(display_long)|uniprotkb:Homeobox protein Hox-1F(gene name synonym)|uniprotkb:HOXA1(gene name)|psi-mi:HOXA1(display_short)|uniprotkb:HOX1F(gene name synonym)	psi-mi:dkk3_human(display_long)|uniprotkb:REIC(gene name synonym)|uniprotkb:UNQ258/PRO295(orf name)|uniprotkb:DKK3(gene name)|psi-mi:DKK3(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512426|imex:IM-28561-123	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005513.1|refseq:NP_705873.2|interpro:IPR001356(Homeobox)|interpro:IPR017970|interpro:IPR020479|interpro:IPR009057(Homeodomain-like)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007634"(optokinetic behavior)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0021599"(abducens nerve formation)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048702"(embryonic neurocranium morphogenesis)|go:"GO:0048839"(inner ear development)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050795"(regulation of behavior)|go:"GO:0050890"(cognition)|go:"GO:0050905"(neuromuscular process)|go:"GO:0060840"(artery development)|go:"GO:0060876"(semicircular canal formation)|go:"GO:0090102"(cochlea development)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|reactome:R-HSA-5617472|mint:P49639	ensembl:ENSG00000050165(gene)|ensembl:ENST00000326932(transcript)|ensembl:ENST00000396505(transcript)|ensembl:ENST00000683431(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030325"(adrenal gland development)|go:"GO:0032348"(negative regulation of aldosterone biosynthetic process)|go:"GO:0039706"(co-receptor binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048019"(receptor antagonist activity)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1902613"(negative regulation of anti-Mullerian hormone signaling pathway)|go:"GO:2000065"(negative regulation of cortisol biosynthetic process)|interpro:IPR006796(Dickkopf, N-terminal cysteine-rich)|interpro:IPR039863|mint:Q9UBP4|refseq:NP_001018067.1|refseq:NP_037385.2|refseq:NP_056965.3|refseq:XP_006718241.1|refseq:NP_001317149.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:QjQVU0uonSpj5vQU0pgzXuXmW3Y9606	rogid:pnbEZP5fAWw3Qxg1gB1sjP0Oyeo9606	rigid:VkL49lZlkZwXBn6oK/nxTnFQkks	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49639	uniprotkb:Q8WWM7	intact:EBI-740785|uniprotkb:O43363|uniprotkb:B2R8U7|uniprotkb:A4D184	intact:EBI-948363|ensembl:ENSP00000338718|uniprotkb:O95135|uniprotkb:Q6NVJ8|uniprotkb:Q6PJW6|uniprotkb:Q8IU61|uniprotkb:Q8IU95|uniprotkb:Q8WWM3|uniprotkb:Q8WWM4|uniprotkb:Q8WWM5|uniprotkb:Q8WWM6|uniprotkb:Q99703|uniprotkb:B9EGM2|uniprotkb:E9PAR9|uniprotkb:A8K1R6|uniprotkb:Q63ZY4	psi-mi:hxa1_human(display_long)|uniprotkb:Homeobox protein Hox-1F(gene name synonym)|uniprotkb:HOXA1(gene name)|psi-mi:HOXA1(display_short)|uniprotkb:HOX1F(gene name synonym)	psi-mi:atx2l_human(display_long)|uniprotkb:Ataxin-2 domain protein(gene name synonym)|uniprotkb:Ataxin-2-related protein(gene name synonym)|uniprotkb:ATXN2L(gene name)|psi-mi:ATXN2L(display_short)|uniprotkb:A2D(gene name synonym)|uniprotkb:A2LG(gene name synonym)|uniprotkb:A2LP(gene name synonym)|uniprotkb:A2RP(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512347|imex:IM-28561-577	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005513.1|refseq:NP_705873.2|interpro:IPR001356(Homeobox)|interpro:IPR017970|interpro:IPR020479|interpro:IPR009057(Homeodomain-like)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007634"(optokinetic behavior)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0021599"(abducens nerve formation)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048702"(embryonic neurocranium morphogenesis)|go:"GO:0048839"(inner ear development)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050795"(regulation of behavior)|go:"GO:0050890"(cognition)|go:"GO:0050905"(neuromuscular process)|go:"GO:0060840"(artery development)|go:"GO:0060876"(semicircular canal formation)|go:"GO:0090102"(cochlea development)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|reactome:R-HSA-5617472|mint:P49639	ensembl:ENSG00000168488(gene)|ensembl:ENST00000336783(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010603"(regulation of cytoplasmic mRNA processing body assembly)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0034063"(stress granule assembly)|go:"GO:0045296"(cadherin binding)|interpro:IPR009604(Ataxin-2, N-terminal)|interpro:IPR009818(Ataxin-2, C-terminal)|interpro:IPR025852|mint:Q8WWM7|refseq:NP_009176.2|refseq:NP_663760.1|refseq:NP_680780.1|refseq:NP_680781.1|refseq:XP_005255123.1|refseq:NP_059867.3|refseq:NP_680782.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:QjQVU0uonSpj5vQU0pgzXuXmW3Y9606	rogid:t7lrS10IM/5pt+rrbqBRowZ6b+09606	rigid:lHnLksJDlwOWcPJcw54NJ8pUTjg	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49639	uniprotkb:Q7L4P6	intact:EBI-740785|uniprotkb:O43363|uniprotkb:B2R8U7|uniprotkb:A4D184	intact:EBI-724373|ensembl:ENSP00000360899|uniprotkb:D3DQ27|uniprotkb:Q96A62|uniprotkb:Q9HAI3|intact:EBI-3044085	psi-mi:hxa1_human(display_long)|uniprotkb:Homeobox protein Hox-1F(gene name synonym)|uniprotkb:HOXA1(gene name)|psi-mi:HOXA1(display_short)|uniprotkb:HOX1F(gene name synonym)	psi-mi:bend5_human(display_long)|uniprotkb:BEND5(gene name)|psi-mi:BEND5(display_short)|uniprotkb:C1orf165(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512354|imex:IM-28561-997	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005513.1|refseq:NP_705873.2|interpro:IPR001356(Homeobox)|interpro:IPR017970|interpro:IPR020479|interpro:IPR009057(Homeodomain-like)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007634"(optokinetic behavior)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0021599"(abducens nerve formation)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048702"(embryonic neurocranium morphogenesis)|go:"GO:0048839"(inner ear development)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050795"(regulation of behavior)|go:"GO:0050890"(cognition)|go:"GO:0050905"(neuromuscular process)|go:"GO:0060840"(artery development)|go:"GO:0060876"(semicircular canal formation)|go:"GO:0090102"(cochlea development)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|reactome:R-HSA-5617472|mint:P49639	refseq:NP_078879.2|ensembl:ENSG00000162373(gene)|ensembl:ENST00000371833(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR018379|interpro:IPR040391|mint:Q7L4P6|refseq:NP_001289011.1|refseq:XP_011540444.1|refseq:XP_016857823.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:QjQVU0uonSpj5vQU0pgzXuXmW3Y9606	rogid:R6OwgNU76FX6tqLRdHVmzEgK8EE9606	rigid:EkN1hw0X9M366KFIKn5ZZAtFQcQ	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49639	uniprotkb:Q9NW68	intact:EBI-740785|uniprotkb:O43363|uniprotkb:B2R8U7|uniprotkb:A4D184	intact:EBI-721848|uniprotkb:B4DMS7|uniprotkb:B4DTP7|uniprotkb:B4E2X8|uniprotkb:Q49AT8|uniprotkb:Q68DY6|uniprotkb:Q6IAA3|uniprotkb:Q6MZK1|uniprotkb:Q6UXS1|uniprotkb:Q9HAL9|uniprotkb:B4DTI7|ensembl:ENSP00000412173	psi-mi:hxa1_human(display_long)|uniprotkb:Homeobox protein Hox-1F(gene name synonym)|uniprotkb:HOXA1(gene name)|psi-mi:HOXA1(display_short)|uniprotkb:HOX1F(gene name synonym)	psi-mi:bsdc1_human(display_long)|uniprotkb:BSDC1(gene name)|psi-mi:BSDC1(display_short)|uniprotkb:UNQ2494/PRO5781(orf name)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512361|imex:IM-28561-1483	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005513.1|refseq:NP_705873.2|interpro:IPR001356(Homeobox)|interpro:IPR017970|interpro:IPR020479|interpro:IPR009057(Homeodomain-like)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007634"(optokinetic behavior)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0021599"(abducens nerve formation)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048702"(embryonic neurocranium morphogenesis)|go:"GO:0048839"(inner ear development)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050795"(regulation of behavior)|go:"GO:0050890"(cognition)|go:"GO:0050905"(neuromuscular process)|go:"GO:0060840"(artery development)|go:"GO:0060876"(semicircular canal formation)|go:"GO:0090102"(cochlea development)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|reactome:R-HSA-5617472|mint:P49639	refseq:NP_001137360.1|refseq:NP_001137361.1|refseq:NP_001137362.1|refseq:NP_060515.3|refseq:NP_001287887.1|ensembl:ENSG00000160058(gene)|ensembl:ENST00000455895(transcript)|interpro:IPR005607(BSD)|interpro:IPR035925|mint:Q9NW68	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:QjQVU0uonSpj5vQU0pgzXuXmW3Y9606	rogid:xURI5Azk5thRty0BOh6UyxlbB4Y9606	rigid:yOPqr19NKMv9WRv9W1q3mpI9SlM	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49639	uniprotkb:A4D161	intact:EBI-740785|uniprotkb:O43363|uniprotkb:B2R8U7|uniprotkb:A4D184	intact:EBI-11960181|ensembl:ENSP00000342576|uniprotkb:Q05CG4|uniprotkb:Q4G0Q7|uniprotkb:Q6P519	psi-mi:hxa1_human(display_long)|uniprotkb:Homeobox protein Hox-1F(gene name synonym)|uniprotkb:HOXA1(gene name)|psi-mi:HOXA1(display_short)|uniprotkb:HOX1F(gene name synonym)	psi-mi:f221a_human(display_long)|uniprotkb:FAM221A(gene name)|psi-mi:FAM221A(display_short)|uniprotkb:C7orf46(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512368|imex:IM-28561-1485	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005513.1|refseq:NP_705873.2|interpro:IPR001356(Homeobox)|interpro:IPR017970|interpro:IPR020479|interpro:IPR009057(Homeodomain-like)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007634"(optokinetic behavior)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0021599"(abducens nerve formation)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048702"(embryonic neurocranium morphogenesis)|go:"GO:0048839"(inner ear development)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050795"(regulation of behavior)|go:"GO:0050890"(cognition)|go:"GO:0050905"(neuromuscular process)|go:"GO:0060840"(artery development)|go:"GO:0060876"(semicircular canal formation)|go:"GO:0090102"(cochlea development)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|reactome:R-HSA-5617472|mint:P49639	ensembl:ENSG00000188732(gene)|ensembl:ENST00000344962(transcript)|interpro:IPR026755|mint:A4D161|refseq:NP_001120836.1|refseq:NP_001120837.1|refseq:NP_001287861.1|refseq:NP_954587.2|refseq:XP_011513671.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:QjQVU0uonSpj5vQU0pgzXuXmW3Y9606	rogid:UzUHn7yeE0pPwhhGwJCSuSsnLPU9606	rigid:BeMVvTruuytd+XcuIWXwdwnvOrI	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49639	uniprotkb:Q86VB7	intact:EBI-740785|uniprotkb:O43363|uniprotkb:B2R8U7|uniprotkb:A4D184	intact:EBI-2808455|ensembl:ENSP00000352071|uniprotkb:Q07901|uniprotkb:Q07898|uniprotkb:Q2VLH7|uniprotkb:Q07899|uniprotkb:Q07900|uniprotkb:C9JIG2	psi-mi:hxa1_human(display_long)|uniprotkb:Homeobox protein Hox-1F(gene name synonym)|uniprotkb:HOXA1(gene name)|psi-mi:HOXA1(display_short)|uniprotkb:HOX1F(gene name synonym)	psi-mi:c163a_human(display_long)|uniprotkb:CD163(gene name)|psi-mi:CD163(display_short)|uniprotkb:M130(gene name synonym)|uniprotkb:Hemoglobin scavenger receptor(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512375|imex:IM-28561-777	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005513.1|refseq:NP_705873.2|interpro:IPR001356(Homeobox)|interpro:IPR017970|interpro:IPR020479|interpro:IPR009057(Homeodomain-like)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007634"(optokinetic behavior)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0021599"(abducens nerve formation)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048702"(embryonic neurocranium morphogenesis)|go:"GO:0048839"(inner ear development)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050795"(regulation of behavior)|go:"GO:0050890"(cognition)|go:"GO:0050905"(neuromuscular process)|go:"GO:0060840"(artery development)|go:"GO:0060876"(semicircular canal formation)|go:"GO:0090102"(cochlea development)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|reactome:R-HSA-5617472|mint:P49639	ensembl:ENSG00000177575(gene)|ensembl:ENST00000359156(transcript)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006953"(acute-phase response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0097110"(scaffold protein binding)|interpro:IPR001190(Speract/scavenger receptor)|interpro:IPR017448(Speract/scavenger receptor related)|interpro:IPR036772|mint:Q86VB7|reactome:R-HSA-2168880|reactome:R-HSA-9662834|refseq:NP_004235.4|refseq:NP_981961.2|refseq:XP_016875720.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:QjQVU0uonSpj5vQU0pgzXuXmW3Y9606	rogid:irBZJ2L9f0SE5YDTxaxokN+J7mg9606	rigid:3Ax6Wd8C78M5y+qrwrBWI8lG280	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49639	uniprotkb:Q9H2X0	intact:EBI-740785|uniprotkb:O43363|uniprotkb:B2R8U7|uniprotkb:A4D184	intact:EBI-947551|intact:EBI-1752274|uniprotkb:O95254|uniprotkb:Q2M1I8|uniprotkb:Q6UW83|uniprotkb:Q9H2D3|uniprotkb:Q9H2W8|uniprotkb:Q9H2W9|uniprotkb:Q9P0Z2|uniprotkb:Q9P0Z3|uniprotkb:Q9P0Z4|uniprotkb:Q9P0Z5|intact:EBI-1957537|ensembl:ENSP00000204604	psi-mi:hxa1_human(display_long)|uniprotkb:Homeobox protein Hox-1F(gene name synonym)|uniprotkb:HOXA1(gene name)|psi-mi:HOXA1(display_short)|uniprotkb:HOX1F(gene name synonym)	psi-mi:chrd_human(display_long)|uniprotkb:CHRD(gene name)|psi-mi:CHRD(display_short)|uniprotkb:UNQ217/PRO243(orf name)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512382|imex:IM-28561-1205	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005513.1|refseq:NP_705873.2|interpro:IPR001356(Homeobox)|interpro:IPR017970|interpro:IPR020479|interpro:IPR009057(Homeodomain-like)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007634"(optokinetic behavior)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0021599"(abducens nerve formation)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048702"(embryonic neurocranium morphogenesis)|go:"GO:0048839"(inner ear development)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050795"(regulation of behavior)|go:"GO:0050890"(cognition)|go:"GO:0050905"(neuromuscular process)|go:"GO:0060840"(artery development)|go:"GO:0060876"(semicircular canal formation)|go:"GO:0090102"(cochlea development)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|reactome:R-HSA-5617472|mint:P49639	refseq:NP_003732.2|refseq:NP_001291401.1|refseq:NP_001291402.1|refseq:NP_001291403.1|dip:DIP-48857N|ensembl:ENSG00000090539(gene)|ensembl:ENST00000204604(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0005615"(extracellular space)|go:"GO:0019955"(cytokine binding)|go:"GO:0021919"(BMP signaling pathway involved in spinal cord dorsal/ventral patterning)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0033504"(floor plate development)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR010895(CHRD)|interpro:IPR016353(Chordin)|mint:Q9H2X0	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:QjQVU0uonSpj5vQU0pgzXuXmW3Y9606	rogid:Y/WHkB30K8nEcaaL2wyikwWH1kg9606	rigid:I+eDPdM/79wV8AmajoNZvdQVxyA	false	sufficient binding region:1-110	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49639	uniprotkb:Q86X95	intact:EBI-740785|uniprotkb:O43363|uniprotkb:B2R8U7|uniprotkb:A4D184	intact:EBI-627102|ensembl:ENSP00000339723|uniprotkb:A6NFI6|uniprotkb:A8K8M4|uniprotkb:O95367|uniprotkb:Q12804|uniprotkb:Q4G1B9|uniprotkb:Q6PJI4|uniprotkb:Q8IWI2	psi-mi:hxa1_human(display_long)|uniprotkb:Homeobox protein Hox-1F(gene name synonym)|uniprotkb:HOXA1(gene name)|psi-mi:HOXA1(display_short)|uniprotkb:HOX1F(gene name synonym)	psi-mi:cir1_human(display_long)|uniprotkb:CIR(gene name synonym)|uniprotkb:CBF1-interacting corepressor(gene name synonym)|uniprotkb:Recepin(gene name synonym)|uniprotkb:CIR1(gene name)|psi-mi:CIR1(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512391|imex:IM-28561-1207	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005513.1|refseq:NP_705873.2|interpro:IPR001356(Homeobox)|interpro:IPR017970|interpro:IPR020479|interpro:IPR009057(Homeodomain-like)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007634"(optokinetic behavior)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0021599"(abducens nerve formation)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048702"(embryonic neurocranium morphogenesis)|go:"GO:0048839"(inner ear development)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050795"(regulation of behavior)|go:"GO:0050890"(cognition)|go:"GO:0050905"(neuromuscular process)|go:"GO:0060840"(artery development)|go:"GO:0060876"(semicircular canal formation)|go:"GO:0090102"(cochlea development)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|reactome:R-HSA-5617472|mint:P49639	ensembl:ENSG00000138433(gene)|ensembl:ENST00000342016(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR019339|interpro:IPR040014|mint:Q86X95|rcsb pdb:6ZYM|refseq:NP_004873.3	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:QjQVU0uonSpj5vQU0pgzXuXmW3Y9606	rogid:DMnBG746eQpvLsf9D+lgeUKnni09606	rigid:JH5fb1D3kwlM4VeysoQdWlhrnSo	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49639	uniprotkb:Q96HD1	intact:EBI-740785|uniprotkb:O43363|uniprotkb:B2R8U7|uniprotkb:A4D184	intact:EBI-713009|uniprotkb:Q6I9X5|uniprotkb:Q8NFT4|uniprotkb:Q9Y409|uniprotkb:A8MX90|uniprotkb:B2RAA9|ensembl:ENSP00000373322|ensembl:ENSP00000393643|ensembl:ENSP00000507127|ensembl:ENSP00000508358	psi-mi:hxa1_human(display_long)|uniprotkb:Homeobox protein Hox-1F(gene name synonym)|uniprotkb:HOXA1(gene name)|psi-mi:HOXA1(display_short)|uniprotkb:HOX1F(gene name synonym)	psi-mi:crel1_human(display_long)|uniprotkb:CRELD1(gene name)|psi-mi:CRELD1(display_short)|uniprotkb:CIRRIN(gene name synonym)|uniprotkb:Cysteine-rich with EGF-like domain protein 1(gene name synonym)|uniprotkb:UNQ188/PRO214(orf name)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512398|imex:IM-28561-1487	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005513.1|refseq:NP_705873.2|interpro:IPR001356(Homeobox)|interpro:IPR017970|interpro:IPR020479|interpro:IPR009057(Homeodomain-like)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007634"(optokinetic behavior)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0021599"(abducens nerve formation)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048702"(embryonic neurocranium morphogenesis)|go:"GO:0048839"(inner ear development)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050795"(regulation of behavior)|go:"GO:0050890"(cognition)|go:"GO:0050905"(neuromuscular process)|go:"GO:0060840"(artery development)|go:"GO:0060876"(semicircular canal formation)|go:"GO:0090102"(cochlea development)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|reactome:R-HSA-5617472|mint:P49639	refseq:NP_001026887.1|refseq:NP_001070883.1|refseq:NP_056328.2|refseq:XP_016862664.1|ensembl:ENSG00000163703(gene)|ensembl:ENST00000383811(transcript)|ensembl:ENST00000452070(transcript)|ensembl:ENST00000682783(transcript)|ensembl:ENST00000684493(transcript)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003279"(cardiac septum development)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002049(EGF-like, laminin)|interpro:IPR006212(Furin-like repeat)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR018097|interpro:IPR021852|mint:Q96HD1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:QjQVU0uonSpj5vQU0pgzXuXmW3Y9606	rogid:YCHTMCBYRLSWAJ4W+2lmt/EjUlQ9606	rigid:Zji1tXok+jniaOEpubZ3G9a67S4	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49639	uniprotkb:Q6UXH1	intact:EBI-740785|uniprotkb:O43363|uniprotkb:B2R8U7|uniprotkb:A4D184	intact:EBI-3935314|uniprotkb:A5GZA5|uniprotkb:Q9BU47|uniprotkb:Q4W0V0|uniprotkb:A5GZA2|uniprotkb:A5GZA4|uniprotkb:Q86UC0|uniprotkb:A5GZA3|ensembl:ENSP00000332223|uniprotkb:A5GZA6	psi-mi:hxa1_human(display_long)|uniprotkb:Homeobox protein Hox-1F(gene name synonym)|uniprotkb:HOXA1(gene name)|psi-mi:HOXA1(display_short)|uniprotkb:HOX1F(gene name synonym)	psi-mi:crel2_human(display_long)|uniprotkb:CRELD2(gene name)|psi-mi:CRELD2(display_short)|uniprotkb:Cysteine-rich with EGF-like domain protein 2(gene name synonym)|uniprotkb:UNQ185/PRO211(orf name)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512405|imex:IM-28561-779	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005513.1|refseq:NP_705873.2|interpro:IPR001356(Homeobox)|interpro:IPR017970|interpro:IPR020479|interpro:IPR009057(Homeodomain-like)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007634"(optokinetic behavior)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0021599"(abducens nerve formation)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048702"(embryonic neurocranium morphogenesis)|go:"GO:0048839"(inner ear development)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050795"(regulation of behavior)|go:"GO:0050890"(cognition)|go:"GO:0050905"(neuromuscular process)|go:"GO:0060840"(artery development)|go:"GO:0060876"(semicircular canal formation)|go:"GO:0090102"(cochlea development)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|reactome:R-HSA-5617472|mint:P49639	refseq:NP_001271246.1|refseq:NP_001271247.1|ensembl:ENSG00000184164(gene)|ensembl:ENST00000328268(transcript)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002049(EGF-like, laminin)|interpro:IPR006212(Furin-like repeat)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR018097|mint:Q6UXH1|refseq:NP_001128573.1|refseq:NP_077300.3|refseq:XP_005261795.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:QjQVU0uonSpj5vQU0pgzXuXmW3Y9606	rogid:MJtefM+QiJRIn/HGdEr6vEd4bB49606	rigid:nqcYAXhZjb9g5OlBpuPLevV0cgk	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49639	uniprotkb:Q8NFT6	intact:EBI-740785|uniprotkb:O43363|uniprotkb:B2R8U7|uniprotkb:A4D184	intact:EBI-749662|uniprotkb:Q8TEX0|uniprotkb:Q9H912|uniprotkb:Q96B19|uniprotkb:D3DX56|ensembl:ENSP00000323663	psi-mi:hxa1_human(display_long)|uniprotkb:Homeobox protein Hox-1F(gene name synonym)|uniprotkb:HOXA1(gene name)|psi-mi:HOXA1(display_short)|uniprotkb:HOX1F(gene name synonym)	psi-mi:dbf4b_human(display_long)|uniprotkb:ASKL1(gene name synonym)|uniprotkb:DRF1(gene name synonym)|uniprotkb:Activator of S phase kinase-like protein 1(gene name synonym)|uniprotkb:Dbf4-related factor 1(gene name synonym)|uniprotkb:Chiffon homolog B(gene name synonym)|uniprotkb:DBF4B(gene name)|psi-mi:DBF4B(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512412|imex:IM-28561-1489	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005513.1|refseq:NP_705873.2|interpro:IPR001356(Homeobox)|interpro:IPR017970|interpro:IPR020479|interpro:IPR009057(Homeodomain-like)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007634"(optokinetic behavior)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0021599"(abducens nerve formation)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048702"(embryonic neurocranium morphogenesis)|go:"GO:0048839"(inner ear development)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050795"(regulation of behavior)|go:"GO:0050890"(cognition)|go:"GO:0050905"(neuromuscular process)|go:"GO:0060840"(artery development)|go:"GO:0060876"(semicircular canal formation)|go:"GO:0090102"(cochlea development)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|reactome:R-HSA-5617472|mint:P49639	refseq:NP_079380.2|refseq:NP_663696.1|refseq:XP_011523583.1|refseq:XP_006722165.1|ensembl:ENSG00000161692(gene)|ensembl:ENST00000315005(transcript)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0007049"(cell cycle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0031431"(Dbf4-dependent protein kinase complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:1901987"(regulation of cell cycle phase transition)|interpro:IPR006572(Zinc finger, DBF-type)|interpro:IPR038545|mint:Q8NFT6|go:"GO:0010571"(positive regulation of nuclear cell cycle DNA replication)	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:QjQVU0uonSpj5vQU0pgzXuXmW3Y9606	rogid:BdvmDAqRsWqg1qbvLLc/uVtXEiI9606	rigid:qTeoeoYkE2ESkKn+Vjxw8wmQ2xY	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49639	uniprotkb:Q14203	intact:EBI-740785|uniprotkb:O43363|uniprotkb:B2R8U7|uniprotkb:A4D184	intact:EBI-724352|uniprotkb:O95296|uniprotkb:Q9BRM9|uniprotkb:Q9UIU1|intact:EBI-28971695|ensembl:ENSP00000487279|uniprotkb:Q9UIU2|uniprotkb:E9PGE1|uniprotkb:G5E9H4|uniprotkb:Q6IQ37|intact:EBI-2560059|uniprotkb:B4DM45|uniprotkb:E9PFS5|uniprotkb:A8MY36|intact:EBI-10962300	psi-mi:hxa1_human(display_long)|uniprotkb:Homeobox protein Hox-1F(gene name synonym)|uniprotkb:HOXA1(gene name)|psi-mi:HOXA1(display_short)|uniprotkb:HOX1F(gene name synonym)	psi-mi:dctn1_human(display_long)|uniprotkb:DCTN1(gene name)|psi-mi:DCTN1(display_short)|uniprotkb:150 kDa dynein-associated polypeptide(gene name synonym)|uniprotkb:DAP-150(gene name synonym)|uniprotkb:p150-glued(gene name synonym)|uniprotkb:p135(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512419|imex:IM-28561-339	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005513.1|refseq:NP_705873.2|interpro:IPR001356(Homeobox)|interpro:IPR017970|interpro:IPR020479|interpro:IPR009057(Homeodomain-like)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007634"(optokinetic behavior)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0021599"(abducens nerve formation)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048702"(embryonic neurocranium morphogenesis)|go:"GO:0048839"(inner ear development)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050795"(regulation of behavior)|go:"GO:0050890"(cognition)|go:"GO:0050905"(neuromuscular process)|go:"GO:0060840"(artery development)|go:"GO:0060876"(semicircular canal formation)|go:"GO:0090102"(cochlea development)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|reactome:R-HSA-5617472|mint:P49639	refseq:NP_001128512.1|refseq:NP_001128513.1|refseq:NP_001177766.1|refseq:NP_004073.2|refseq:NP_075408.1|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-381038|reactome:R-HSA-5620912|reactome:R-HSA-6807878|reactome:R-HSA-6811436|reactome:R-HSA-8854518|reactome:R-HSA-380259|ensembl:ENSG00000204843(gene)|ensembl:ENST00000628224(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005938"(cell cortex)|go:"GO:0007097"(nuclear migration)|go:"GO:0007399"(nervous system development)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008017"(microtubule binding)|go:"GO:0010457"(centriole-centriole cohesion)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0015631"(tubulin binding)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021517"(ventral spinal cord development)|go:"GO:0030286"(dynein complex)|go:"GO:0030424"(axon)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0034454"(microtubule anchoring at centrosome)|go:"GO:0035371"(microtubule plus-end)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045171"(intercellular bridge)|go:"GO:0048156"(tau protein binding)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051081"(nuclear membrane disassembly)|go:"GO:0051301"(cell division)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0061744"(motor behavior)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0099558"(maintenance of synapse structure)|go:"GO:0099738"(cell cortex region)|go:"GO:0120103"(centriolar subdistal appendage)|go:"GO:1904398"(positive regulation of neuromuscular junction development)|go:"GO:1905515"(non-motile cilium assembly)|go:"GO:1990535"(neuron projection maintenance)|interpro:IPR000938(Cytoskeleton-associated protein, CAP-Gly)|interpro:IPR022157|interpro:IPR036859|mint:Q14203|rcsb pdb:1TXQ|rcsb pdb:2COY|rcsb pdb:2HKN|rcsb pdb:2HKQ|rcsb pdb:2HL3|rcsb pdb:2HL5|rcsb pdb:2HQH|rcsb pdb:3E2U|rcsb pdb:3TQ7|reactome:R-HSA-2132295|reactome:R-HSA-2565942|reactome:R-HSA-3371497|ensembl:ENST00000394003|ensembl:ENSP00000377571|ensembl:ENST00000409240|ensembl:ENSP00000386406|ensembl:ENST00000409438|ensembl:ENSP00000387270|ensembl:ENST00000409567|ensembl:ENSP00000386843|ensembl:ENSP00000487279|ensembl:ENST00000633691|ensembl:ENSP00000487724|refseq:NP_001177765.1|dip:DIP-31365N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:QjQVU0uonSpj5vQU0pgzXuXmW3Y9606	rogid:PKchWdLWycCErGzSVMXq/xCQJRM9606	rigid:NK5grE0KYI4ZOIJdppORWzBKl/Y	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49639	uniprotkb:P68104	intact:EBI-740785|uniprotkb:O43363|uniprotkb:B2R8U7|uniprotkb:A4D184	intact:EBI-352162|uniprotkb:P04719|uniprotkb:P04720|intact:EBI-2834776|intact:EBI-8011754|intact:MINT-4903558|uniprotkb:Q6IQ15|ensembl:ENSP00000330054|ensembl:ENSP00000339053|ensembl:ENSP00000339063|ensembl:ENSP00000348651|ensembl:ENSP00000392366|ensembl:ENSP00000479055|ensembl:ENSP00000503192|ensembl:ENSP00000503249|ensembl:ENSP00000503823|ensembl:ENSP00000504335|intact:EBI-16423274	psi-mi:hxa1_human(display_long)|uniprotkb:Homeobox protein Hox-1F(gene name synonym)|uniprotkb:HOXA1(gene name)|psi-mi:HOXA1(display_short)|uniprotkb:HOX1F(gene name synonym)	psi-mi:ef1a1_human(display_long)|uniprotkb:EEF1A1(gene name)|psi-mi:EEF1A1(display_short)|uniprotkb:EEF1A(gene name synonym)|uniprotkb:EF1A(gene name synonym)|uniprotkb:LENG7(gene name synonym)|uniprotkb:Eukaryotic elongation factor 1 A-1(gene name synonym)|uniprotkb:Elongation factor Tu(gene name synonym)|uniprotkb:Leukocyte receptor cluster member 7(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512433|imex:IM-28561-999	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005513.1|refseq:NP_705873.2|interpro:IPR001356(Homeobox)|interpro:IPR017970|interpro:IPR020479|interpro:IPR009057(Homeodomain-like)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007634"(optokinetic behavior)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0021599"(abducens nerve formation)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048702"(embryonic neurocranium morphogenesis)|go:"GO:0048839"(inner ear development)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050795"(regulation of behavior)|go:"GO:0050890"(cognition)|go:"GO:0050905"(neuromuscular process)|go:"GO:0060840"(artery development)|go:"GO:0060876"(semicircular canal formation)|go:"GO:0090102"(cochlea development)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|reactome:R-HSA-5617472|mint:P49639	refseq:XP_011533816.1|ensembl:ENSG00000156508(gene)|ensembl:ENST00000309268(transcript)|ensembl:ENST00000316292(transcript)|ensembl:ENST00000331523(transcript)|ensembl:ENST00000356303(transcript)|ensembl:ENST00000455918(transcript)|ensembl:ENST00000615060(transcript)|ensembl:ENST00000676710(transcript)|ensembl:ENST00000677236(transcript)|ensembl:ENST00000678508(transcript)|ensembl:ENST00000678702(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0005853"(eukaryotic translation elongation factor 1 complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0006412"(translation)|go:"GO:0006414"(translational elongation)|go:"GO:0016020"(membrane)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0032587"(ruffle membrane)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0098574"(cytoplasmic side of lysosomal membrane)|go:"GO:1900022"(regulation of D-erythro-sphingosine kinase activity)|go:"GO:1904714"(regulation of chaperone-mediated autophagy)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004160(Translation elongation factor EFTu/EF1A, C-terminal)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR004539(Translation elongation factor EF1A, eukaryotic and archaeal)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR009001(Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal)|interpro:IPR027417|interpro:IPR031157|mint:P68104|rcsb pdb:1SYW|rcsb pdb:3C5J|rcsb pdb:6ZMO|reactome:R-HSA-156842|reactome:R-HSA-156902|reactome:R-HSA-3371511|reactome:R-HSA-6798695|reactome:R-HSA-8876725|reactome:R-HSA-9613829|dip:DIP-31277N|refseq:NP_001393.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:QjQVU0uonSpj5vQU0pgzXuXmW3Y9606	rogid:d3REF87FDKboAjyvlJJEXtqhrcw9606	rigid:Iy5i/Spi+Q8LDp9ltTywy3g212o	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49639	uniprotkb:Q12805	intact:EBI-740785|uniprotkb:O43363|uniprotkb:B2R8U7|uniprotkb:A4D184	intact:EBI-536772|uniprotkb:Q541U7|uniprotkb:A8K3I4|uniprotkb:D6W5D2|ensembl:ENSP00000347596|ensembl:ENSP00000378058|uniprotkb:B4DW75	psi-mi:hxa1_human(display_long)|uniprotkb:Homeobox protein Hox-1F(gene name synonym)|uniprotkb:HOXA1(gene name)|psi-mi:HOXA1(display_short)|uniprotkb:HOX1F(gene name synonym)	psi-mi:fbln3_human(display_long)|uniprotkb:Fibulin-3(gene name synonym)|uniprotkb:Fibrillin-like protein(gene name synonym)|uniprotkb:Extracellular protein S1-5(gene name synonym)|uniprotkb:EFEMP1(gene name)|psi-mi:EFEMP1(display_short)|uniprotkb:FBLN3(gene name synonym)|uniprotkb:FBNL(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512440|imex:IM-28561-341	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005513.1|refseq:NP_705873.2|interpro:IPR001356(Homeobox)|interpro:IPR017970|interpro:IPR020479|interpro:IPR009057(Homeodomain-like)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007634"(optokinetic behavior)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0021599"(abducens nerve formation)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048702"(embryonic neurocranium morphogenesis)|go:"GO:0048839"(inner ear development)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050795"(regulation of behavior)|go:"GO:0050890"(cognition)|go:"GO:0050905"(neuromuscular process)|go:"GO:0060840"(artery development)|go:"GO:0060876"(semicircular canal formation)|go:"GO:0090102"(cochlea development)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|reactome:R-HSA-5617472|mint:P49639	ensembl:ENSG00000115380(gene)|ensembl:ENST00000355426(transcript)|ensembl:ENST00000394555(transcript)|go:"GO:0005006"(epidermal growth factor-activated receptor activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007601"(visual perception)|go:"GO:0008083"(growth factor activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0043010"(camera-type eye development)|go:"GO:0048048"(embryonic eye morphogenesis)|go:"GO:0048050"(post-embryonic eye morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR018097|interpro:IPR026823|interpro:IPR032973|mint:Q12805|reactome:R-HSA-2129379|refseq:NP_001034437.1|refseq:NP_001034438.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:QjQVU0uonSpj5vQU0pgzXuXmW3Y9606	rogid:V32dS+EEp5Syu3A6lQJal0fg6UM9606	rigid:sjH8I0la/ZkSc+RPxjfMJO7nmKc	false	sufficient binding region:1-110	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49639	uniprotkb:O95967	intact:EBI-740785|uniprotkb:O43363|uniprotkb:B2R8U7|uniprotkb:A4D184	intact:EBI-743414|uniprotkb:O75967|uniprotkb:A8K7R4|uniprotkb:B3KM31|uniprotkb:B3KQT1|ensembl:ENSP00000309953|ensembl:ENSP00000435295	psi-mi:hxa1_human(display_long)|uniprotkb:Homeobox protein Hox-1F(gene name synonym)|uniprotkb:HOXA1(gene name)|psi-mi:HOXA1(display_short)|uniprotkb:HOX1F(gene name synonym)	psi-mi:fbln4_human(display_long)|uniprotkb:Fibulin-4(gene name synonym)|uniprotkb:Protein UPH1(gene name synonym)|uniprotkb:EFEMP2(gene name)|psi-mi:EFEMP2(display_short)|uniprotkb:FBLN4(gene name synonym)|uniprotkb:UNQ200/PRO226(orf name)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512449|imex:IM-28561-1001	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005513.1|refseq:NP_705873.2|interpro:IPR001356(Homeobox)|interpro:IPR017970|interpro:IPR020479|interpro:IPR009057(Homeodomain-like)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007634"(optokinetic behavior)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0021599"(abducens nerve formation)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048702"(embryonic neurocranium morphogenesis)|go:"GO:0048839"(inner ear development)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050795"(regulation of behavior)|go:"GO:0050890"(cognition)|go:"GO:0050905"(neuromuscular process)|go:"GO:0060840"(artery development)|go:"GO:0060876"(semicircular canal formation)|go:"GO:0090102"(cochlea development)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|reactome:R-HSA-5617472|mint:P49639	refseq:NP_058634.4|ensembl:ENSG00000172638(gene)|ensembl:ENST00000307998(transcript)|ensembl:ENST00000531972(transcript)|go:"GO:0001527"(microfibril)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0008201"(heparin binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035904"(aorta development)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0048251"(elastic fiber assembly)|go:"GO:0060414"(aorta smooth muscle tissue morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071953"(elastic fiber)|go:"GO:0097084"(vascular associated smooth muscle cell development)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1904026"(regulation of collagen fibril organization)|go:"GO:1904028"(positive regulation of collagen fibril organization)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904831"(positive regulation of aortic smooth muscle cell differentiation)|go:"GO:1905609"(positive regulation of smooth muscle cell-matrix adhesion)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR018097|interpro:IPR026823|interpro:IPR026824|mint:O95967|rcsb pdb:2KL7|reactome:R-HSA-2129379|dip:DIP-34518N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:QjQVU0uonSpj5vQU0pgzXuXmW3Y9606	rogid:L8jMp8rFYb6DRRusfWgyd9zN2KI9606	rigid:ZdlTioS12GNd86zGZQQKNXm1KJU	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49639	uniprotkb:Q9UHF1	intact:EBI-740785|uniprotkb:O43363|uniprotkb:B2R8U7|uniprotkb:A4D184	intact:EBI-949532|ensembl:ENSP00000307843|ensembl:ENSP00000360763|ensembl:ENSP00000360764|ensembl:ENSP00000385639|uniprotkb:Q5M7Y5|uniprotkb:Q5VUD5|uniprotkb:Q96EG0|uniprotkb:B3KRP0|uniprotkb:M9VTX9	psi-mi:hxa1_human(display_long)|uniprotkb:Homeobox protein Hox-1F(gene name synonym)|uniprotkb:HOXA1(gene name)|psi-mi:HOXA1(display_short)|uniprotkb:HOX1F(gene name synonym)	psi-mi:egfl7_human(display_long)|uniprotkb:Multiple epidermal growth factor-like domains protein 7(gene name synonym)|uniprotkb:Zneu1(gene name synonym)|uniprotkb:Vascular endothelial statin(gene name synonym)|uniprotkb:NOTCH4-like protein(gene name synonym)|uniprotkb:EGFL7(gene name)|psi-mi:EGFL7(display_short)|uniprotkb:MEGF7(gene name synonym)|uniprotkb:UNQ187/PRO1449(orf name)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512456|imex:IM-28561-343	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005513.1|refseq:NP_705873.2|interpro:IPR001356(Homeobox)|interpro:IPR017970|interpro:IPR020479|interpro:IPR009057(Homeodomain-like)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007634"(optokinetic behavior)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0021599"(abducens nerve formation)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048702"(embryonic neurocranium morphogenesis)|go:"GO:0048839"(inner ear development)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050795"(regulation of behavior)|go:"GO:0050890"(cognition)|go:"GO:0050905"(neuromuscular process)|go:"GO:0060840"(artery development)|go:"GO:0060876"(semicircular canal formation)|go:"GO:0090102"(cochlea development)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|reactome:R-HSA-5617472|mint:P49639	ensembl:ENSG00000172889(gene)|ensembl:ENST00000308874(transcript)|ensembl:ENST00000371698(transcript)|ensembl:ENST00000371699(transcript)|ensembl:ENST00000406555(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001568"(blood vessel development)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0007155"(cell adhesion)|go:"GO:0009986"(cell surface)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0048856"(anatomical structure development)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011489(EMI)|interpro:IPR013111(EGF, extracellular)|interpro:IPR018097|mint:Q9UHF1|go:"GO:0005576"(extracellular region)|refseq:NP_057299.1|refseq:NP_958854.1|refseq:XP_011517066.1|refseq:XP_011517067.1|refseq:XP_011517068.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:QjQVU0uonSpj5vQU0pgzXuXmW3Y9606	rogid:HzaJXQm4JE8bXXE+/ugmqGjpjZA9606	rigid:pEurvdGnBRvrMOP0HjsyS7Ic6Wc	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49639	uniprotkb:P23142	intact:EBI-740785|uniprotkb:O43363|uniprotkb:B2R8U7|uniprotkb:A4D184	intact:EBI-726652|uniprotkb:P23143|uniprotkb:P23144|uniprotkb:P37888|uniprotkb:Q5TIC4|uniprotkb:Q8TBH8|uniprotkb:Q9HBQ5|uniprotkb:Q9UC21|uniprotkb:Q9UGR4|uniprotkb:Q9UH41|uniprotkb:B0QY42|intact:EBI-2562209|ensembl:ENSP00000331544|uniprotkb:B1AHL4	psi-mi:hxa1_human(display_long)|uniprotkb:Homeobox protein Hox-1F(gene name synonym)|uniprotkb:HOXA1(gene name)|psi-mi:HOXA1(display_short)|uniprotkb:HOX1F(gene name synonym)	psi-mi:fbln1_human(display_long)|uniprotkb:FBLN1(gene name)|psi-mi:FBLN1(display_short)|uniprotkb:PP213(orf name)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512463|imex:IM-28561-1003	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005513.1|refseq:NP_705873.2|interpro:IPR001356(Homeobox)|interpro:IPR017970|interpro:IPR020479|interpro:IPR009057(Homeodomain-like)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007634"(optokinetic behavior)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0021599"(abducens nerve formation)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048702"(embryonic neurocranium morphogenesis)|go:"GO:0048839"(inner ear development)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050795"(regulation of behavior)|go:"GO:0050890"(cognition)|go:"GO:0050905"(neuromuscular process)|go:"GO:0060840"(artery development)|go:"GO:0060876"(semicircular canal formation)|go:"GO:0090102"(cochlea development)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|reactome:R-HSA-5617472|mint:P49639	refseq:NP_001987.2|refseq:NP_006476.2|refseq:NP_006477.2|refseq:NP_006478.2|ensembl:ENSG00000077942(gene)|ensembl:ENST00000327858(transcript)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001968"(fibronectin binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007566"(embryo implantation)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070051"(fibrinogen binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071635"(negative regulation of transforming growth factor beta production)|go:"GO:0071953"(elastic fiber)|go:"GO:0072378"(blood coagulation, fibrin clot formation)|go:"GO:1900025"(negative regulation of substrate adhesion-dependent cell spreading)|go:"GO:1904188"(negative regulation of transformation of host cell by virus)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000647"(negative regulation of stem cell proliferation)|interpro:IPR000020(Anaphylatoxin/fibulin)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR017048(Fibulin-1)|interpro:IPR018097|interpro:IPR026823|mint:P23142|reactome:R-HSA-2129379|go:"GO:0005201"(extracellular matrix structural constituent)	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:QjQVU0uonSpj5vQU0pgzXuXmW3Y9606	rogid:a47ZJLXWeghGIY9xJTQI7VujuMk9606	rigid:xljn3XMNMGvIoYOKcwypcVKTwiw	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49639	uniprotkb:P98095	intact:EBI-740785|uniprotkb:O43363|uniprotkb:B2R8U7|uniprotkb:A4D184	intact:EBI-947973|uniprotkb:B7Z9C5|uniprotkb:Q8IUI0|uniprotkb:Q8IUI1|ensembl:ENSP00000295760	psi-mi:hxa1_human(display_long)|uniprotkb:Homeobox protein Hox-1F(gene name synonym)|uniprotkb:HOXA1(gene name)|psi-mi:HOXA1(display_short)|uniprotkb:HOX1F(gene name synonym)	psi-mi:fbln2_human(display_long)|uniprotkb:FBLN2(gene name)|psi-mi:FBLN2(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512470|imex:IM-28561-345	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005513.1|refseq:NP_705873.2|interpro:IPR001356(Homeobox)|interpro:IPR017970|interpro:IPR020479|interpro:IPR009057(Homeodomain-like)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007634"(optokinetic behavior)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0021599"(abducens nerve formation)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048702"(embryonic neurocranium morphogenesis)|go:"GO:0048839"(inner ear development)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050795"(regulation of behavior)|go:"GO:0050890"(cognition)|go:"GO:0050905"(neuromuscular process)|go:"GO:0060840"(artery development)|go:"GO:0060876"(semicircular canal formation)|go:"GO:0090102"(cochlea development)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|reactome:R-HSA-5617472|mint:P49639	refseq:NP_001004019.1|refseq:NP_001158507.1|refseq:NP_001989.2|ensembl:ENSG00000163520(gene)|ensembl:ENST00000295760(transcript)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0030023"(extracellular matrix constituent conferring elasticity)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:1903561"(extracellular vesicle)|interpro:IPR000020(Anaphylatoxin/fibulin)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR018097|interpro:IPR026823|interpro:IPR037286|mint:P98095|reactome:R-HSA-2129379	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:QjQVU0uonSpj5vQU0pgzXuXmW3Y9606	rogid:HoVQ3qvVH6GlAeeI8VEXtIwbkgY9606	rigid:xk7ASd4UftBLVcIfigxL2hLUurE	false	sufficient binding region:1-110	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49639	uniprotkb:Q9UBX5	intact:EBI-740785|uniprotkb:O43363|uniprotkb:B2R8U7|uniprotkb:A4D184	intact:EBI-947897|uniprotkb:O75966|uniprotkb:Q6UWA3|uniprotkb:Q6IAL4|ensembl:ENSP00000345008	psi-mi:hxa1_human(display_long)|uniprotkb:Homeobox protein Hox-1F(gene name synonym)|uniprotkb:HOXA1(gene name)|psi-mi:HOXA1(display_short)|uniprotkb:HOX1F(gene name synonym)	psi-mi:fbln5_human(display_long)|uniprotkb:Developmental arteries and neural crest EGF-like protein(gene name synonym)|uniprotkb:Urine p50 protein(gene name synonym)|uniprotkb:FBLN5(gene name)|psi-mi:FBLN5(display_short)|uniprotkb:DANCE(gene name synonym)|uniprotkb:UNQ184/PRO210(orf name)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512479|imex:IM-28561-1209	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005513.1|refseq:NP_705873.2|interpro:IPR001356(Homeobox)|interpro:IPR017970|interpro:IPR020479|interpro:IPR009057(Homeodomain-like)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007634"(optokinetic behavior)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0021599"(abducens nerve formation)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048702"(embryonic neurocranium morphogenesis)|go:"GO:0048839"(inner ear development)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050795"(regulation of behavior)|go:"GO:0050890"(cognition)|go:"GO:0050905"(neuromuscular process)|go:"GO:0060840"(artery development)|go:"GO:0060876"(semicircular canal formation)|go:"GO:0090102"(cochlea development)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|reactome:R-HSA-5617472|mint:P49639	refseq:NP_006320.2|dip:DIP-44301N|ensembl:ENSG00000140092(gene)|ensembl:ENST00000342058(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046903"(secretion)|go:"GO:0048251"(elastic fiber assembly)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:2000121"(regulation of removal of superoxide radicals)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR018097|interpro:IPR026823|interpro:IPR037288|mint:Q9UBX5|reactome:R-HSA-1566948|reactome:R-HSA-2129379	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:QjQVU0uonSpj5vQU0pgzXuXmW3Y9606	rogid:1fqx+PBkfO9F1/5wXcNasL9R8Mk9606	rigid:fAGpbidL6GiI96jOhkMEsuoCy3k	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49639	uniprotkb:P35555	intact:EBI-740785|uniprotkb:O43363|uniprotkb:B2R8U7|uniprotkb:A4D184	intact:EBI-2505934|ensembl:ENSP00000325527|uniprotkb:B2RUU0|uniprotkb:Q15972|uniprotkb:Q75N87|uniprotkb:D2JYH6	psi-mi:hxa1_human(display_long)|uniprotkb:Homeobox protein Hox-1F(gene name synonym)|uniprotkb:HOXA1(gene name)|psi-mi:HOXA1(display_short)|uniprotkb:HOX1F(gene name synonym)	psi-mi:fbn1_human(display_long)|uniprotkb:FBN1(gene name)|psi-mi:FBN1(display_short)|uniprotkb:FBN(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512486|imex:IM-28561-125	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005513.1|refseq:NP_705873.2|interpro:IPR001356(Homeobox)|interpro:IPR017970|interpro:IPR020479|interpro:IPR009057(Homeodomain-like)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007634"(optokinetic behavior)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0021599"(abducens nerve formation)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048702"(embryonic neurocranium morphogenesis)|go:"GO:0048839"(inner ear development)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050795"(regulation of behavior)|go:"GO:0050890"(cognition)|go:"GO:0050905"(neuromuscular process)|go:"GO:0060840"(artery development)|go:"GO:0060876"(semicircular canal formation)|go:"GO:0090102"(cochlea development)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|reactome:R-HSA-5617472|mint:P49639	ensembl:ENSG00000166147(gene)|ensembl:ENST00000316623(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001527"(microfibril)|go:"GO:0001656"(metanephros development)|go:"GO:0005178"(integrin binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0007507"(heart development)|go:"GO:0008201"(heparin binding)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0030023"(extracellular matrix constituent conferring elasticity)|go:"GO:0031012"(extracellular matrix)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0034199"(activation of protein kinase A activity)|go:"GO:0035582"(sequestering of BMP in extracellular matrix)|go:"GO:0035583"(sequestering of TGFbeta in extracellular matrix)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043010"(camera-type eye development)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0048048"(embryonic eye morphogenesis)|go:"GO:0048050"(post-embryonic eye morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:2001205"(negative regulation of osteoclast development)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011398(Fibrillin)|interpro:IPR017878|interpro:IPR018097|interpro:IPR026823|interpro:IPR036773|interpro:IPR040872|mint:P35555|rcsb pdb:1APJ|rcsb pdb:1EMN|rcsb pdb:1EMO|rcsb pdb:1LMJ|rcsb pdb:1UZJ|rcsb pdb:1UZK|rcsb pdb:1UZP|rcsb pdb:1UZQ|rcsb pdb:2M74|rcsb pdb:2W86|rcsb pdb:5MS9|reactome:R-HSA-1474228|reactome:R-HSA-1566948|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_000129.3|dip:DIP-29985N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:QjQVU0uonSpj5vQU0pgzXuXmW3Y9606	rogid:YEO0ZRTezrjEAyTaos1pm2hUDXg9606	rigid:HhuEQ+pgDeqhCtXv0DkuQZ+CDEI	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49639	uniprotkb:P02751	intact:EBI-740785|uniprotkb:O43363|uniprotkb:B2R8U7|uniprotkb:A4D184	intact:EBI-1220319|uniprotkb:Q7Z391|uniprotkb:O95609|uniprotkb:O95610|uniprotkb:Q14312|uniprotkb:Q14325|uniprotkb:Q14326|uniprotkb:Q17RV7|uniprotkb:Q585T2|uniprotkb:Q59EH1|uniprotkb:Q60FE4|uniprotkb:Q68DP8|uniprotkb:Q68DP9|uniprotkb:Q68DT4|uniprotkb:Q6LDP6|uniprotkb:Q6MZU5|uniprotkb:Q6N025|uniprotkb:Q6N0A6|uniprotkb:Q86T27|uniprotkb:Q8IVI8|uniprotkb:Q96KP7|uniprotkb:Q96KP8|uniprotkb:Q96KP9|uniprotkb:Q9H1B8|uniprotkb:Q9HAP3|uniprotkb:Q9UMK2|uniprotkb:Q6MZS0|uniprotkb:B7ZLF0|uniprotkb:E9PE77|uniprotkb:E9PG29|uniprotkb:Q564H7|uniprotkb:Q53S27|ensembl:ENSP00000346839	psi-mi:hxa1_human(display_long)|uniprotkb:Homeobox protein Hox-1F(gene name synonym)|uniprotkb:HOXA1(gene name)|psi-mi:HOXA1(display_short)|uniprotkb:HOX1F(gene name synonym)	psi-mi:finc_human(display_long)|uniprotkb:FN1(gene name)|psi-mi:FN1(display_short)|uniprotkb:FN(gene name synonym)|uniprotkb:Cold-insoluble globulin(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512493|imex:IM-28561-579	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005513.1|refseq:NP_705873.2|interpro:IPR001356(Homeobox)|interpro:IPR017970|interpro:IPR020479|interpro:IPR009057(Homeodomain-like)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007634"(optokinetic behavior)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0021599"(abducens nerve formation)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048702"(embryonic neurocranium morphogenesis)|go:"GO:0048839"(inner ear development)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050795"(regulation of behavior)|go:"GO:0050890"(cognition)|go:"GO:0050905"(neuromuscular process)|go:"GO:0060840"(artery development)|go:"GO:0060876"(semicircular canal formation)|go:"GO:0090102"(cochlea development)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|reactome:R-HSA-5617472|mint:P49639	refseq:NP_002017.1|refseq:NP_473375.2|refseq:NP_997639.1|refseq:NP_997641.1|refseq:NP_997643.1|refseq:NP_997647.1|refseq:NP_001293058.1|refseq:NP_001293059.1|refseq:NP_001293060.1|refseq:NP_001293061.1|refseq:XP_005246463.1|dip:DIP-29547N|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009611"(response to wounding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0019899"(enzyme binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0033622"(integrin activation)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0051087"(chaperone binding)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|ensembl:ENSG00000115414(gene)|ensembl:ENST00000354785(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005577"(fibrinogen complex)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006953"(acute-phase response)|go:"GO:0007044"(cell-substrate junction assembly)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007161"(calcium-independent cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071635"(negative regulation of transforming growth factor beta production)|go:"GO:0072378"(blood coagulation, fibrin clot formation)|go:"GO:0072562"(blood microparticle)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1901166"(neural crest cell migration involved in autonomic nervous system development)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|interpro:IPR000083(Fibronectin, type I)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013806(Kringle-like fold)|interpro:IPR036116|interpro:IPR036943|mint:P02751|rcsb pdb:1E88|rcsb pdb:1E8B|rcsb pdb:1FBR|rcsb pdb:1FNA|rcsb pdb:1FNF|rcsb pdb:1FNH|rcsb pdb:1J8K|rcsb pdb:1O9A|rcsb pdb:1OWW|rcsb pdb:1Q38|rcsb pdb:1QGB|rcsb pdb:1QO6|rcsb pdb:1TTF|rcsb pdb:1TTG|rcsb pdb:2CG6|rcsb pdb:2CG7|rcsb pdb:2CK2|rcsb pdb:2CKU|rcsb pdb:2EC3|rcsb pdb:2FN2|rcsb pdb:2FNB|rcsb pdb:2GEE|rcsb pdb:2H41|rcsb pdb:2H45|rcsb pdb:2HA1|rcsb pdb:2MNU|rcsb pdb:2N1K|rcsb pdb:2OCF|rcsb pdb:2RKY|rcsb pdb:2RKZ|rcsb pdb:2RL0|rcsb pdb:3CAL|rcsb pdb:3EJH|rcsb pdb:3GXE|rcsb pdb:3M7P|rcsb pdb:3MQL|rcsb pdb:3R8Q|rcsb pdb:3T1W|rcsb pdb:3ZRZ|rcsb pdb:4GH7|rcsb pdb:4JE4|rcsb pdb:4JEG|rcsb pdb:4LXO|rcsb pdb:4MMX|rcsb pdb:4MMY|rcsb pdb:4MMZ|rcsb pdb:4PZ5|rcsb pdb:5DC0|rcsb pdb:5DC4|rcsb pdb:5DC9|rcsb pdb:5DFT|rcsb pdb:5J6Z|rcsb pdb:5J7C|rcsb pdb:5M0A|rcsb pdb:5N47|rcsb pdb:5N48|rcsb pdb:6HNF|rcsb pdb:6MFA|rcsb pdb:6MSV|rcsb pdb:6NAJ|rcsb pdb:6XAX|rcsb pdb:6XAY|rcsb pdb:7NWL|reactome:R-HSA-114608|reactome:R-HSA-1474228|reactome:R-HSA-1474244|reactome:R-HSA-1566977|reactome:R-HSA-202733|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-3000170|reactome:R-HSA-3000171|reactome:R-HSA-3000178|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-381426|reactome:R-HSA-5674135|reactome:R-HSA-6785807|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8874081|reactome:R-HSA-8957275|reactome:R-HSA-9649948|reactome:R-HSA-9656223	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:QjQVU0uonSpj5vQU0pgzXuXmW3Y9606	rogid:4arZu49X8b+dthqaX4DIh59V8h09606	rigid:oWnrwDfH2UyyZamABGSmR03lUzw	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49639	uniprotkb:O14841	intact:EBI-740785|uniprotkb:O43363|uniprotkb:B2R8U7|uniprotkb:A4D184	intact:EBI-3938544|uniprotkb:Q9Y4Q0|uniprotkb:Q75W65|uniprotkb:A5PKY8|ensembl:ENSP00000480476	psi-mi:hxa1_human(display_long)|uniprotkb:Homeobox protein Hox-1F(gene name synonym)|uniprotkb:HOXA1(gene name)|psi-mi:HOXA1(display_short)|uniprotkb:HOX1F(gene name synonym)	psi-mi:opla_human(display_long)|uniprotkb:OPLAH(gene name)|psi-mi:OPLAH(display_short)|uniprotkb:5-oxo-L-prolinase(gene name synonym)|uniprotkb:Pyroglutamase(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512652|imex:IM-28561-1019	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005513.1|refseq:NP_705873.2|interpro:IPR001356(Homeobox)|interpro:IPR017970|interpro:IPR020479|interpro:IPR009057(Homeodomain-like)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007634"(optokinetic behavior)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0021599"(abducens nerve formation)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048702"(embryonic neurocranium morphogenesis)|go:"GO:0048839"(inner ear development)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050795"(regulation of behavior)|go:"GO:0050890"(cognition)|go:"GO:0050905"(neuromuscular process)|go:"GO:0060840"(artery development)|go:"GO:0060876"(semicircular canal formation)|go:"GO:0090102"(cochlea development)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|reactome:R-HSA-5617472|mint:P49639	ensembl:ENSG00000178814(gene)|ensembl:ENST00000618853(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0017168"("5-oxoprolinase (ATP-hydrolyzing) activity")|go:"GO:0042802"(identical protein binding)|interpro:IPR002821(Hydantoinase/oxoprolinase)|interpro:IPR003692(Hydantoinase B/oxoprolinase)|interpro:IPR008040(Hydantoinaseoxoprolinase, N-terminal)|mint:O14841|reactome:R-HSA-174403|reactome:R-HSA-5578998|refseq:NP_060040.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:QjQVU0uonSpj5vQU0pgzXuXmW3Y9606	rogid:9Y4toRkLUqqb+G4+sCVzpeBZe8c9606	rigid:pRJQ7bRT+cyAKC5il7p+Xtb+0YY	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49639	uniprotkb:Q9Y219	intact:EBI-740785|uniprotkb:O43363|uniprotkb:B2R8U7|uniprotkb:A4D184	intact:EBI-946223|uniprotkb:Q9UE17|uniprotkb:Q9UE99|uniprotkb:Q9UNK8|uniprotkb:Q9Y6P9|uniprotkb:Q9Y6Q0|ensembl:ENSP00000328169	psi-mi:hxa1_human(display_long)|uniprotkb:Homeobox protein Hox-1F(gene name synonym)|uniprotkb:HOXA1(gene name)|psi-mi:HOXA1(display_short)|uniprotkb:HOX1F(gene name synonym)	psi-mi:jag2_human(display_long)|uniprotkb:JAG2(gene name)|psi-mi:JAG2(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512509|imex:IM-28561-1211	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005513.1|refseq:NP_705873.2|interpro:IPR001356(Homeobox)|interpro:IPR017970|interpro:IPR020479|interpro:IPR009057(Homeodomain-like)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007634"(optokinetic behavior)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0021599"(abducens nerve formation)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048702"(embryonic neurocranium morphogenesis)|go:"GO:0048839"(inner ear development)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050795"(regulation of behavior)|go:"GO:0050890"(cognition)|go:"GO:0050905"(neuromuscular process)|go:"GO:0060840"(artery development)|go:"GO:0060876"(semicircular canal formation)|go:"GO:0090102"(cochlea development)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|reactome:R-HSA-5617472|mint:P49639	refseq:NP_002217.3|refseq:NP_660142.1|ensembl:ENSG00000184916(gene)|ensembl:ENST00000331782(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003016"(respiratory system process)|go:"GO:0005112"(Notch binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008083"(growth factor activity)|go:"GO:0009912"(auditory receptor cell fate commitment)|go:"GO:0016331"(morphogenesis of embryonic epithelium)|go:"GO:0030154"(cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030217"(T cell differentiation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042492"(gamma-delta T cell differentiation)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:1990134"(epithelial cell apoptotic process involved in palatal shelf morphogenesis)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR001774("Delta/Serrate/lag-2 (DSL) protein")|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011651(Notch ligand, N-terminal)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR018097|interpro:IPR026219|mint:Q9Y219|rcsb pdb:5MW5|rcsb pdb:5MW7|rcsb pdb:5MWF|reactome:R-HSA-2122948|reactome:R-HSA-2644606|reactome:R-HSA-2660826|reactome:R-HSA-2691232|go:"GO:0005887"(integral component of plasma membrane)|reactome:R-HSA-2894862|reactome:R-HSA-2979096|reactome:R-HSA-9013507	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:QjQVU0uonSpj5vQU0pgzXuXmW3Y9606	rogid:GoH5Lw1zl+3dhA4RSpJTyQ0LY4Q9606	rigid:fxoFZ0/Kj+EaOAMBMNB929b8jUQ	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49639	uniprotkb:P48745	intact:EBI-740785|uniprotkb:O43363|uniprotkb:B2R8U7|uniprotkb:A4D184	intact:EBI-3904822|uniprotkb:Q6I9S3|uniprotkb:Q9UDE4|uniprotkb:Q96BY5|uniprotkb:B2R5X7|ensembl:ENSP00000259526	psi-mi:hxa1_human(display_long)|uniprotkb:Homeobox protein Hox-1F(gene name synonym)|uniprotkb:HOXA1(gene name)|psi-mi:HOXA1(display_short)|uniprotkb:HOX1F(gene name synonym)	psi-mi:ccn3_human(display_long)|uniprotkb:CCN3(gene name)|psi-mi:CCN3(display_short)|uniprotkb:Cellular communication network factor 3(gene name synonym)|uniprotkb:IGFBP9(gene name synonym)|uniprotkb:Insulin-like growth factor-binding protein 9(gene name synonym)|uniprotkb:NOV(gene name synonym)|uniprotkb:NOVH(gene name synonym)|uniprotkb:Nephro blastoma-overexpressed gene protein homolog(gene name synonym)|uniprotkb:Protein NOV homolog(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512638|imex:IM-28561-1017	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005513.1|refseq:NP_705873.2|interpro:IPR001356(Homeobox)|interpro:IPR017970|interpro:IPR020479|interpro:IPR009057(Homeodomain-like)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007634"(optokinetic behavior)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0021599"(abducens nerve formation)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048702"(embryonic neurocranium morphogenesis)|go:"GO:0048839"(inner ear development)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050795"(regulation of behavior)|go:"GO:0050890"(cognition)|go:"GO:0050905"(neuromuscular process)|go:"GO:0060840"(artery development)|go:"GO:0060876"(semicircular canal formation)|go:"GO:0090102"(cochlea development)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|reactome:R-HSA-5617472|mint:P49639	refseq:NP_002505.1|ensembl:ENSG00000136999(gene)|ensembl:ENST00000259526(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0005112"(Notch binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005921"(gap junction)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010761"(fibroblast migration)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0014909"(smooth muscle cell migration)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031012"(extracellular matrix)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0035767"(endothelial cell chemotaxis)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044342"(type B pancreatic cell proliferation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0048659"(smooth muscle cell proliferation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060392"(negative regulation of SMAD protein signal transduction)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061484"(hematopoietic stem cell homeostasis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071603"(endothelial cell-cell adhesion)|go:"GO:0090027"(negative regulation of monocyte chemotaxis)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1902731"(negative regulation of chondrocyte proliferation)|go:"GO:1904057"(negative regulation of sensory perception of pain)|go:"GO:1990523"(bone regeneration)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR006208(Cystine knot)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR012395(IGFBP-related, CNN)|interpro:IPR017891|interpro:IPR036383|interpro:IPR043973|mint:P48745	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:QjQVU0uonSpj5vQU0pgzXuXmW3Y9606	rogid:3IUgIO3Q676ryvJXOCfCvHmcC789606	rigid:El+O05mqU4dT3y0x9p/LJtfPBbI	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49639	uniprotkb:Q9UM47	intact:EBI-740785|uniprotkb:O43363|uniprotkb:B2R8U7|uniprotkb:A4D184	intact:EBI-1236377|uniprotkb:Q9UEB3|uniprotkb:Q9UPL3|uniprotkb:Q9Y6L8|ensembl:ENSP00000263388	psi-mi:hxa1_human(display_long)|uniprotkb:Homeobox protein Hox-1F(gene name synonym)|uniprotkb:HOXA1(gene name)|psi-mi:HOXA1(display_short)|uniprotkb:HOX1F(gene name synonym)	psi-mi:notc3_human(display_long)|uniprotkb:NOTCH3(gene name)|psi-mi:NOTCH3(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512631|imex:IM-28561-1695	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005513.1|refseq:NP_705873.2|interpro:IPR001356(Homeobox)|interpro:IPR017970|interpro:IPR020479|interpro:IPR009057(Homeodomain-like)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007634"(optokinetic behavior)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0021599"(abducens nerve formation)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048702"(embryonic neurocranium morphogenesis)|go:"GO:0048839"(inner ear development)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050795"(regulation of behavior)|go:"GO:0050890"(cognition)|go:"GO:0050905"(neuromuscular process)|go:"GO:0060840"(artery development)|go:"GO:0060876"(semicircular canal formation)|go:"GO:0090102"(cochlea development)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|reactome:R-HSA-5617472|mint:P49639	refseq:NP_000426.2|ensembl:ENSP00000263388|dip:DIP-39827N|ensembl:ENSG00000074181(gene)|ensembl:ENST00000263388(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0009986"(cell surface)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043235"(receptor complex)|go:"GO:0045296"(cadherin binding)|go:"GO:0050793"(regulation of developmental process)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000800(Notch region)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002110(Ankyrin)|interpro:IPR008297(Notch)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR010660(Notch, NOD region)|interpro:IPR011656(Notch, NODP region)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR018097|interpro:IPR020683|interpro:IPR022331|interpro:IPR024600|interpro:IPR035993|interpro:IPR036770|mint:Q9UM47|rcsb pdb:4ZLP|rcsb pdb:5CZV|rcsb pdb:5CZX|rcsb pdb:6WQU|reactome:R-HSA-1912399|reactome:R-HSA-1912408|reactome:R-HSA-1912420|reactome:R-HSA-350054|reactome:R-HSA-5083630|reactome:R-HSA-9013507|reactome:R-HSA-9013508|reactome:R-HSA-9017802	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:QjQVU0uonSpj5vQU0pgzXuXmW3Y9606	rogid:hOarWT2DBhNVF6AhV/z+NqLCEv49606	rigid:X9PtRe6PBRrSEYHdA6dX7SQ1OiI	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49639	uniprotkb:P46531	intact:EBI-740785|uniprotkb:O43363|uniprotkb:B2R8U7|uniprotkb:A4D184	intact:EBI-636374|uniprotkb:Q59ED8|uniprotkb:Q5SXM3|intact:EBI-28989124|ensembl:ENSP00000498587	psi-mi:hxa1_human(display_long)|uniprotkb:Homeobox protein Hox-1F(gene name synonym)|uniprotkb:HOXA1(gene name)|psi-mi:HOXA1(display_short)|uniprotkb:HOX1F(gene name synonym)	psi-mi:notc1_human(display_long)|uniprotkb:Translocation-associated notch protein TAN-1(gene name synonym)|uniprotkb:NOTCH1(gene name)|psi-mi:NOTCH1(display_short)|uniprotkb:TAN1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512624|imex:IM-28561-1015	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005513.1|refseq:NP_705873.2|interpro:IPR001356(Homeobox)|interpro:IPR017970|interpro:IPR020479|interpro:IPR009057(Homeodomain-like)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007634"(optokinetic behavior)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0021599"(abducens nerve formation)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048702"(embryonic neurocranium morphogenesis)|go:"GO:0048839"(inner ear development)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050795"(regulation of behavior)|go:"GO:0050890"(cognition)|go:"GO:0050905"(neuromuscular process)|go:"GO:0060840"(artery development)|go:"GO:0060876"(semicircular canal formation)|go:"GO:0090102"(cochlea development)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|reactome:R-HSA-5617472|mint:P49639	refseq:NP_060087.3|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007221"(positive regulation of transcription of Notch receptor target)|go:"GO:0005912"(adherens junction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007386"(compartment pattern specification)|go:"GO:0007411"(axon guidance)|go:"GO:0007440"(foregut morphogenesis)|go:"GO:0007492"(endoderm development)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009912"(auditory receptor cell fate commitment)|go:"GO:0009986"(cell surface)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0014031"(mesenchymal cell development)|go:"GO:0014807"(regulation of somitogenesis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0021515"(cell differentiation in spinal cord)|go:"GO:0021915"(neural tube development)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030900"(forebrain development)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035148"(tube formation)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042802"(identical protein binding)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045603"(positive regulation of endothelial cell differentiation)|go:"GO:0045608"(negative regulation of inner ear auditory receptor cell differentiation)|go:"GO:0045618"(positive regulation of keratinocyte differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045955"(negative regulation of calcium ion-dependent exocytosis)|go:"GO:0045967"(negative regulation of growth rate)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046533"(negative regulation of photoreceptor cell differentiation)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048103"(somatic stem cell division)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0048715"(negative regulation of oligodendrocyte differentiation)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060253"(negative regulation of glial cell proliferation)|go:"GO:0060271"(cilium assembly)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060354"(negative regulation of cell adhesion molecule production)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060528"(secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development)|go:"GO:0060740"(prostate gland epithelium morphogenesis)|go:"GO:0060768"(regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0060842"(arterial endothelial cell differentiation)|go:"GO:0060843"(venous endothelial cell differentiation)|go:"GO:0060948"(cardiac vascular smooth muscle cell development)|go:"GO:0060956"(endocardial cell differentiation)|go:"GO:0060979"(vasculogenesis involved in coronary vascular morphogenesis)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0061314"(Notch signaling involved in heart development)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0072144"(glomerular mesangial cell development)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0061384"(heart trabecula morphogenesis)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:1901201"(regulation of extracellular matrix assembly)|go:"GO:0062043"(positive regulation of cardiac epithelial to mesenchymal transition)|go:"GO:0070168"(negative regulation of biomineral tissue development)|go:"GO:1902263"(apoptotic process involved in embryonic digit morphogenesis)|go:"GO:1902339"(positive regulation of apoptotic process involved in morphogenesis)|go:"GO:1903849"(positive regulation of aorta morphogenesis)|go:"GO:2000048"(negative regulation of cell-cell adhesion mediated by cadherin)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2000974"(negative regulation of pro-B cell differentiation)|go:"GO:2001027"(negative regulation of endothelial cell chemotaxis)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000800(Notch region)|go:"GO:0070986"(left/right axis specification)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002110(Ankyrin)|interpro:IPR008297(Notch)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR010660(Notch, NOD region)|interpro:IPR011656(Notch, NODP region)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR018097|interpro:IPR020683|interpro:IPR022362|interpro:IPR024600|go:"GO:0071372"(cellular response to follicle-stimulating hormone stimulus)|interpro:IPR035993|interpro:IPR036770|mint:P46531|rcsb pdb:1PB5|rcsb pdb:1TOZ|rcsb pdb:1YYH|rcsb pdb:2F8X|rcsb pdb:2F8Y|rcsb pdb:2HE0|go:"GO:0072017"(distal tubule development)|go:"GO:0072044"(collecting duct development)|rcsb pdb:2VJ3|rcsb pdb:3ETO|rcsb pdb:3I08|rcsb pdb:3L95|rcsb pdb:3NBN|rcsb pdb:3V79|rcsb pdb:4CUD|rcsb pdb:4CUE|rcsb pdb:4CUF|rcsb pdb:4D0E|rcsb pdb:4D0F|rcsb pdb:5FM9|rcsb pdb:5FMA|rcsb pdb:5KZO|rcsb pdb:5L0R|rcsb pdb:5UB5|rcsb pdb:6IDF|rcsb pdb:6PY8|reactome:R-HSA-1912399|reactome:R-HSA-1912408|reactome:R-HSA-1912420|reactome:R-HSA-210744|reactome:R-HSA-2122947|reactome:R-HSA-2122948|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2660826|reactome:R-HSA-2691232|reactome:R-HSA-2894862|reactome:R-HSA-350054|reactome:R-HSA-5083630|reactome:R-HSA-8941856|reactome:R-HSA-9013508|reactome:R-HSA-9013695|ensembl:ENSG00000148400(gene)|ensembl:ENST00000651671(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001708"(cell fate specification)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001889"(liver development)|go:"GO:0001947"(heart looping)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002193"(MAML1-RBP-Jkappa- ICN1 complex)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003157"(endocardium development)|go:"GO:0003160"(endocardium morphogenesis)|go:"GO:0003162"(atrioventricular node development)|go:"GO:0003169"(coronary vein morphogenesis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003182"(coronary sinus valve morphogenesis)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0003192"(mitral valve formation)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003207"(cardiac chamber formation)|go:"GO:0003208"(cardiac ventricle morphogenesis)|go:"GO:0003209"(cardiac atrium morphogenesis)|go:"GO:0003213"(cardiac right atrium morphogenesis)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0003219"(cardiac right ventricle formation)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003241"(growth involved in heart morphogenesis)|go:"GO:0003252"(negative regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0003256"(regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation)|go:"GO:0003270"(Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation)|go:"GO:0003273"(cell migration involved in endocardial cushion formation)|go:"GO:0003332"(negative regulation of extracellular matrix constituent secretion)|go:"GO:0003344"(pericardium morphogenesis)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005112"(Notch binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|dip:DIP-29919N|ensembl:ENSP00000498587	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:QjQVU0uonSpj5vQU0pgzXuXmW3Y9606	rogid:yRAjMjynnyZ7ANlk2eulodpS4P09606	rigid:dOvj8s7q/l21x0EpDgM956NhOVg	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49639	uniprotkb:Q99435	intact:EBI-740785|uniprotkb:O43363|uniprotkb:B2R8U7|uniprotkb:A4D184	intact:EBI-946274|intact:EBI-2845314|uniprotkb:B7Z2U7|uniprotkb:B7Z5Q4|uniprotkb:B7Z9J5|uniprotkb:B7Z9U3|uniprotkb:Q96JS2|ensembl:ENSP00000390680|ensembl:ENSP00000394612	psi-mi:hxa1_human(display_long)|uniprotkb:Homeobox protein Hox-1F(gene name synonym)|uniprotkb:HOXA1(gene name)|psi-mi:HOXA1(display_short)|uniprotkb:HOX1F(gene name synonym)	psi-mi:nell2_human(display_long)|uniprotkb:NELL2(gene name)|psi-mi:NELL2(display_short)|uniprotkb:NRP2(gene name synonym)|uniprotkb:NEL-like protein 2(gene name synonym)|uniprotkb:Nel-related protein 2(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512615|imex:IM-28561-1497	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005513.1|refseq:NP_705873.2|interpro:IPR001356(Homeobox)|interpro:IPR017970|interpro:IPR020479|interpro:IPR009057(Homeodomain-like)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007634"(optokinetic behavior)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0021599"(abducens nerve formation)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048702"(embryonic neurocranium morphogenesis)|go:"GO:0048839"(inner ear development)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050795"(regulation of behavior)|go:"GO:0050890"(cognition)|go:"GO:0050905"(neuromuscular process)|go:"GO:0060840"(artery development)|go:"GO:0060876"(semicircular canal formation)|go:"GO:0090102"(cochlea development)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|reactome:R-HSA-5617472|mint:P49639	refseq:NP_001138579.1|refseq:NP_001138580.1|refseq:NP_001138581.1|refseq:NP_001138582.1|refseq:NP_006150.1|refseq:XP_011536698.1|refseq:XP_005268962.1|dip:DIP-49927N|ensembl:ENSG00000184613(gene)|ensembl:ENST00000429094(transcript)|ensembl:ENST00000452445(transcript)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0008201"(heparin binding)|go:"GO:0070050"(neuron cellular homeostasis)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR001791(Laminin G)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR018097|mint:Q99435|rcsb pdb:6POG|reactome:R-HSA-428542	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:QjQVU0uonSpj5vQU0pgzXuXmW3Y9606	rogid:/NYlmX9iC3H17WXd+u97CVwOD7c9606	rigid:bQDs60l3tf3HaY8/W1CwbcoIfAs	false	sufficient binding region:1-110	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49639	uniprotkb:Q92832	intact:EBI-740785|uniprotkb:O43363|uniprotkb:B2R8U7|uniprotkb:A4D184	intact:EBI-947754|uniprotkb:Q4VB91|uniprotkb:Q4VB90|uniprotkb:B2CKC1|uniprotkb:Q9Y472|uniprotkb:Q6NSY8|ensembl:ENSP00000349654	psi-mi:hxa1_human(display_long)|uniprotkb:Homeobox protein Hox-1F(gene name synonym)|uniprotkb:HOXA1(gene name)|psi-mi:HOXA1(display_short)|uniprotkb:HOX1F(gene name synonym)	psi-mi:nell1_human(display_long)|uniprotkb:NEL-like protein 1(gene name synonym)|uniprotkb:Nel-related protein 1(gene name synonym)|uniprotkb:NELL1(gene name)|psi-mi:NELL1(display_short)|uniprotkb:NRP1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512606|imex:IM-28561-1495	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005513.1|refseq:NP_705873.2|interpro:IPR001356(Homeobox)|interpro:IPR017970|interpro:IPR020479|interpro:IPR009057(Homeodomain-like)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007634"(optokinetic behavior)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0021599"(abducens nerve formation)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048702"(embryonic neurocranium morphogenesis)|go:"GO:0048839"(inner ear development)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050795"(regulation of behavior)|go:"GO:0050890"(cognition)|go:"GO:0050905"(neuromuscular process)|go:"GO:0060840"(artery development)|go:"GO:0060876"(semicircular canal formation)|go:"GO:0090102"(cochlea development)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|reactome:R-HSA-5617472|mint:P49639	refseq:NP_006148.2|refseq:NP_963845.1|refseq:NP_001275642.1|refseq:NP_001275643.1|ensembl:ENSG00000165973(gene)|ensembl:ENST00000357134(transcript)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0007399"(nervous system development)|go:"GO:0008201"(heparin binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0030154"(cell differentiation)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0033689"(negative regulation of osteoblast proliferation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:1903363"(negative regulation of cellular protein catabolic process)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR001791(Laminin G)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR018097|interpro:IPR024731|mint:Q92832|rcsb pdb:6POL	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:QjQVU0uonSpj5vQU0pgzXuXmW3Y9606	rogid:nC7vtd2PeL7K7QjSVJDoDJE3owk9606	rigid:T9gLt2Y79D6GQN6fKyX0cjfNtBY	false	sufficient binding region:1-110	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49639	uniprotkb:Q13015	intact:EBI-740785|uniprotkb:O43363|uniprotkb:B2R8U7|uniprotkb:A4D184	intact:EBI-6269719|ensembl:ENSP00000357917	psi-mi:hxa1_human(display_long)|uniprotkb:Homeobox protein Hox-1F(gene name synonym)|uniprotkb:HOXA1(gene name)|psi-mi:HOXA1(display_short)|uniprotkb:HOX1F(gene name synonym)	psi-mi:af1q_human(display_long)|uniprotkb:MLLT11(gene name)|psi-mi:MLLT11(display_short)|uniprotkb:AF1Q(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512599|imex:IM-28561-1013	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005513.1|refseq:NP_705873.2|interpro:IPR001356(Homeobox)|interpro:IPR017970|interpro:IPR020479|interpro:IPR009057(Homeodomain-like)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007634"(optokinetic behavior)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0021599"(abducens nerve formation)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048702"(embryonic neurocranium morphogenesis)|go:"GO:0048839"(inner ear development)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050795"(regulation of behavior)|go:"GO:0050890"(cognition)|go:"GO:0050905"(neuromuscular process)|go:"GO:0060840"(artery development)|go:"GO:0060876"(semicircular canal formation)|go:"GO:0090102"(cochlea development)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|reactome:R-HSA-5617472|mint:P49639	ensembl:ENSG00000213190(gene)|ensembl:ENST00000368921(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR026778|interpro:IPR033461|mint:Q13015|refseq:NP_006809.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:QjQVU0uonSpj5vQU0pgzXuXmW3Y9606	rogid:23mnJAG1OcDgM7eT2rTi1Gv0ZgA9606	rigid:ZCcvxHJNHGig58g9q0J9Fa/jEUI	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49639	uniprotkb:Q7Z7M0	intact:EBI-740785|uniprotkb:O43363|uniprotkb:B2R8U7|uniprotkb:A4D184	intact:EBI-947617|uniprotkb:O75097|uniprotkb:A8KAY0|ensembl:ENSP00000251268	psi-mi:hxa1_human(display_long)|uniprotkb:Homeobox protein Hox-1F(gene name synonym)|uniprotkb:HOXA1(gene name)|psi-mi:HOXA1(display_short)|uniprotkb:HOX1F(gene name synonym)	psi-mi:megf8_human(display_long)|uniprotkb:MEGF8(gene name)|psi-mi:MEGF8(display_short)|uniprotkb:EGFL4(gene name synonym)|uniprotkb:KIAA0817(gene name synonym)|uniprotkb:Epidermal growth factor-like protein 4(gene name synonym)|uniprotkb:C19orf49(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512592|imex:IM-28561-1011	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005513.1|refseq:NP_705873.2|interpro:IPR001356(Homeobox)|interpro:IPR017970|interpro:IPR020479|interpro:IPR009057(Homeodomain-like)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007634"(optokinetic behavior)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0021599"(abducens nerve formation)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048702"(embryonic neurocranium morphogenesis)|go:"GO:0048839"(inner ear development)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050795"(regulation of behavior)|go:"GO:0050890"(cognition)|go:"GO:0050905"(neuromuscular process)|go:"GO:0060840"(artery development)|go:"GO:0060876"(semicircular canal formation)|go:"GO:0090102"(cochlea development)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|reactome:R-HSA-5617472|mint:P49639	refseq:NP_001401.2|refseq:NP_001258867.1|ensembl:ENSG00000105429(gene)|ensembl:ENST00000251268(transcript)|go:"GO:0003143"(embryonic heart tube morphogenesis)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009888"(tissue development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0035108"(limb morphogenesis)|go:"GO:0042074"(cell migration involved in gastrulation)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0055113"(epiboly involved in gastrulation with mouth forming second)|go:"GO:0060971"(embryonic heart tube left/right pattern formation)|go:"GO:0060972"(left/right pattern formation)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0061371"(determination of heart left/right asymmetry)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071907"(determination of digestive tract left/right asymmetry)|go:"GO:0097094"(craniofacial suture morphogenesis)|go:"GO:0097155"(fasciculation of sensory neuron axon)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000859(CUB)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002049(EGF-like, laminin)|interpro:IPR002165(Plexin)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR016201(Plexin-like fold)|interpro:IPR018097|interpro:IPR024731|interpro:IPR035914|mint:Q7Z7M0|go:"GO:0048704"(embryonic skeletal system morphogenesis)	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:QjQVU0uonSpj5vQU0pgzXuXmW3Y9606	rogid:NaA9e3P2Wh8y5vrZQQPOYHh8ogc9606	rigid:GUoux3lS79J6TgAFJyu94SXV2J0	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49639	uniprotkb:O75095	intact:EBI-740785|uniprotkb:O43363|uniprotkb:B2R8U7|uniprotkb:A4D184	intact:EBI-947597|uniprotkb:Q5VV39|uniprotkb:Q4AC86|ensembl:ENSP00000348982	psi-mi:hxa1_human(display_long)|uniprotkb:Homeobox protein Hox-1F(gene name synonym)|uniprotkb:HOXA1(gene name)|psi-mi:HOXA1(display_short)|uniprotkb:HOX1F(gene name synonym)	psi-mi:megf6_human(display_long)|uniprotkb:MEGF6(gene name)|psi-mi:MEGF6(display_short)|uniprotkb:EGFL3(gene name synonym)|uniprotkb:KIAA0815(gene name synonym)|uniprotkb:Epidermal growth factor-like protein 3(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512585|imex:IM-28561-129	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005513.1|refseq:NP_705873.2|interpro:IPR001356(Homeobox)|interpro:IPR017970|interpro:IPR020479|interpro:IPR009057(Homeodomain-like)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007634"(optokinetic behavior)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0021599"(abducens nerve formation)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048702"(embryonic neurocranium morphogenesis)|go:"GO:0048839"(inner ear development)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050795"(regulation of behavior)|go:"GO:0050890"(cognition)|go:"GO:0050905"(neuromuscular process)|go:"GO:0060840"(artery development)|go:"GO:0060876"(semicircular canal formation)|go:"GO:0090102"(cochlea development)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|reactome:R-HSA-5617472|mint:P49639	refseq:NP_001400.3|ensembl:ENSG00000162591(gene)|ensembl:ENST00000356575(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002049(EGF-like, laminin)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011489(EMI)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR018097|mint:O75095	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:QjQVU0uonSpj5vQU0pgzXuXmW3Y9606	rogid:/4HcLiv4UEW2qmvoV2OTj110y1I9606	rigid:L05qUcvJqtjpLG7gKS6/qbyI7Cc	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49639	uniprotkb:Q9BYQ6	intact:EBI-740785|uniprotkb:O43363|uniprotkb:B2R8U7|uniprotkb:A4D184	intact:EBI-10302392|uniprotkb:A0AUY2|ensembl:ENSP00000375232|ensembl:ENSP00000460506	psi-mi:hxa1_human(display_long)|uniprotkb:Homeobox protein Hox-1F(gene name synonym)|uniprotkb:HOXA1(gene name)|psi-mi:HOXA1(display_short)|uniprotkb:HOX1F(gene name synonym)	psi-mi:kr411_human(display_long)|uniprotkb:KRTAP4-11(gene name)|psi-mi:KRTAP4-11(display_short)|uniprotkb:KAP4.14(gene name synonym)|uniprotkb:KRTAP4-14(gene name synonym)|uniprotkb:KRTAP4.11(gene name synonym)|uniprotkb:KRTAP4.14(gene name synonym)|uniprotkb:Keratin-associated protein 4-14(gene name synonym)|uniprotkb:Keratin-associated protein 4.11(gene name synonym)|uniprotkb:Keratin-associated protein 4.14(gene name synonym)|uniprotkb:Ultrahigh sulfur keratin-associated protein 4.14(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512516|imex:IM-28561-1007	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005513.1|refseq:NP_705873.2|interpro:IPR001356(Homeobox)|interpro:IPR017970|interpro:IPR020479|interpro:IPR009057(Homeodomain-like)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007634"(optokinetic behavior)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0021599"(abducens nerve formation)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048702"(embryonic neurocranium morphogenesis)|go:"GO:0048839"(inner ear development)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050795"(regulation of behavior)|go:"GO:0050890"(cognition)|go:"GO:0050905"(neuromuscular process)|go:"GO:0060840"(artery development)|go:"GO:0060876"(semicircular canal formation)|go:"GO:0090102"(cochlea development)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|reactome:R-HSA-5617472|mint:P49639	refseq:NP_149048.2|ensembl:ENSG00000212721(gene)|ensembl:ENSG00000263229(gene)|ensembl:ENST00000391413(transcript)|ensembl:ENST00000573418(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0045095"(keratin filament)|interpro:IPR002494(Keratin, high sulphur B2 protein)|mint:Q9BYQ6|reactome:R-HSA-6805567	-	-	-	figure legend:ST2|figure legend:"MI:0612"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:QjQVU0uonSpj5vQU0pgzXuXmW3Y9606	rogid:AZh0MvilW8F33CYBzCk1f9sSyfU9606	rigid:bqGsm0Bs4T43uqRIW+utVDtitHY	false	sufficient binding region:1-110	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49639	uniprotkb:Q99750	intact:EBI-740785|uniprotkb:O43363|uniprotkb:B2R8U7|uniprotkb:A4D184	intact:EBI-724076|ensembl:ENSP00000230321|ensembl:ENSP00000362142	psi-mi:hxa1_human(display_long)|uniprotkb:Homeobox protein Hox-1F(gene name synonym)|uniprotkb:HOXA1(gene name)|psi-mi:HOXA1(display_short)|uniprotkb:HOX1F(gene name synonym)	psi-mi:mdfi_human(display_long)|uniprotkb:Myogenic repressor I-mf(gene name synonym)|uniprotkb:MDFI(gene name)|psi-mi:MDFI(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512578|imex:IM-28561-1009	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005513.1|refseq:NP_705873.2|interpro:IPR001356(Homeobox)|interpro:IPR017970|interpro:IPR020479|interpro:IPR009057(Homeodomain-like)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007634"(optokinetic behavior)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0021599"(abducens nerve formation)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048702"(embryonic neurocranium morphogenesis)|go:"GO:0048839"(inner ear development)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050795"(regulation of behavior)|go:"GO:0050890"(cognition)|go:"GO:0050905"(neuromuscular process)|go:"GO:0060840"(artery development)|go:"GO:0060876"(semicircular canal formation)|go:"GO:0090102"(cochlea development)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|reactome:R-HSA-5617472|mint:P49639	refseq:NP_005577.1|ensembl:ENSG00000112559(gene)|ensembl:ENST00000230321(transcript)|ensembl:ENST00000373051(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0060707"(trophoblast giant cell differentiation)|go:"GO:0140416"(transcription regulator inhibitor activity)|interpro:IPR026134|mint:Q99750|refseq:NP_001287733.1|refseq:NP_001287734.1|refseq:NP_001287735.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:QjQVU0uonSpj5vQU0pgzXuXmW3Y9606	rogid:V3vU0fihMOW18DMHAiDbuZ3asNU9606	rigid:3H1NMfDLucI9qgBhWTUzh2x6aug	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49639	uniprotkb:Q9Y383	intact:EBI-740785|uniprotkb:O43363|uniprotkb:B2R8U7|uniprotkb:A4D184	intact:EBI-352851|ensembl:ENSP00000347005|uniprotkb:Q8IUP9|uniprotkb:Q9NVL3|uniprotkb:Q9NVN7|uniprotkb:Q9UQN1|uniprotkb:B7Z500	psi-mi:hxa1_human(display_long)|uniprotkb:Homeobox protein Hox-1F(gene name synonym)|uniprotkb:HOXA1(gene name)|psi-mi:HOXA1(display_short)|uniprotkb:HOX1F(gene name synonym)	psi-mi:lc7l2_human(display_long)|uniprotkb:LUC7L2(gene name)|psi-mi:LUC7L2(display_short)|uniprotkb:CGI-59(orf name)|uniprotkb:CGI-74(orf name)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512571|imex:IM-28561-127	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005513.1|refseq:NP_705873.2|interpro:IPR001356(Homeobox)|interpro:IPR017970|interpro:IPR020479|interpro:IPR009057(Homeodomain-like)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007634"(optokinetic behavior)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0021599"(abducens nerve formation)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048702"(embryonic neurocranium morphogenesis)|go:"GO:0048839"(inner ear development)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050795"(regulation of behavior)|go:"GO:0050890"(cognition)|go:"GO:0050905"(neuromuscular process)|go:"GO:0060840"(artery development)|go:"GO:0060876"(semicircular canal formation)|go:"GO:0090102"(cochlea development)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|reactome:R-HSA-5617472|mint:P49639	ensembl:ENSG00000146963(gene)|ensembl:ENST00000354926(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005685"(U1 snRNP)|go:"GO:0006376"(mRNA splice site selection)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0071004"(U2-type prespliceosome)|interpro:IPR004882(LUC7 related)|mint:Q9Y383|refseq:NP_057103.2|refseq:NP_001231514.1|refseq:NP_001257572.1|dip:DIP-32513N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:QjQVU0uonSpj5vQU0pgzXuXmW3Y9606	rogid:WLp3u1YbXtdPGzIm6WxvAbrQKhM9606	rigid:SbsthJYCAhas5vYWqnOHacffqtY	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49639	uniprotkb:Q8N2S1	intact:EBI-740785|uniprotkb:O43363|uniprotkb:B2R8U7|uniprotkb:A4D184	intact:EBI-947718|uniprotkb:O75412|uniprotkb:O75413|uniprotkb:O00508|ensembl:ENSP00000311905	psi-mi:hxa1_human(display_long)|uniprotkb:Homeobox protein Hox-1F(gene name synonym)|uniprotkb:HOXA1(gene name)|psi-mi:HOXA1(display_short)|uniprotkb:HOX1F(gene name synonym)	psi-mi:ltbp4_human(display_long)|uniprotkb:LTBP4(gene name)|psi-mi:LTBP4(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512562|imex:IM-28561-349	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005513.1|refseq:NP_705873.2|interpro:IPR001356(Homeobox)|interpro:IPR017970|interpro:IPR020479|interpro:IPR009057(Homeodomain-like)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007634"(optokinetic behavior)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0021599"(abducens nerve formation)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048702"(embryonic neurocranium morphogenesis)|go:"GO:0048839"(inner ear development)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050795"(regulation of behavior)|go:"GO:0050890"(cognition)|go:"GO:0050905"(neuromuscular process)|go:"GO:0060840"(artery development)|go:"GO:0060876"(semicircular canal formation)|go:"GO:0090102"(cochlea development)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|reactome:R-HSA-5617472|mint:P49639	refseq:NP_001036009.1|refseq:NP_001036010.1|refseq:NP_003564.2|ensembl:ENSG00000090006(gene)|ensembl:ENST00000308370(transcript)|go:"GO:0001527"(microfibril)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006457"(protein folding)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007275"(multicellular organism development)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0030252"(growth hormone secretion)|go:"GO:0031012"(extracellular matrix)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0048251"(elastic fiber assembly)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR017878|interpro:IPR018097|interpro:IPR036773|mint:Q8N2S1|reactome:R-HSA-2129379	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:QjQVU0uonSpj5vQU0pgzXuXmW3Y9606	rogid:mBWo9asZp3rjkytgvTD+7OE5K5I9606	rigid:f+pyYQnTlPxIBOkKS1AGVq+BdIc	false	sufficient binding region:1-110	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49639	uniprotkb:Q9NS15	intact:EBI-740785|uniprotkb:O43363|uniprotkb:B2R8U7|uniprotkb:A4D184	intact:EBI-3927098|uniprotkb:Q9H7K2|uniprotkb:Q96HB9|uniprotkb:Q9UFN4|uniprotkb:O15107|ensembl:ENSP00000301873	psi-mi:hxa1_human(display_long)|uniprotkb:Homeobox protein Hox-1F(gene name synonym)|uniprotkb:HOXA1(gene name)|psi-mi:HOXA1(display_short)|uniprotkb:HOX1F(gene name synonym)	psi-mi:ltbp3_human(display_long)|uniprotkb:LTBP3(gene name)|psi-mi:LTBP3(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512553|imex:IM-28561-347	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005513.1|refseq:NP_705873.2|interpro:IPR001356(Homeobox)|interpro:IPR017970|interpro:IPR020479|interpro:IPR009057(Homeodomain-like)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007634"(optokinetic behavior)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0021599"(abducens nerve formation)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048702"(embryonic neurocranium morphogenesis)|go:"GO:0048839"(inner ear development)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050795"(regulation of behavior)|go:"GO:0050890"(cognition)|go:"GO:0050905"(neuromuscular process)|go:"GO:0060840"(artery development)|go:"GO:0060876"(semicircular canal formation)|go:"GO:0090102"(cochlea development)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|reactome:R-HSA-5617472|mint:P49639	refseq:NP_001123616.1|refseq:NP_001157738.1|refseq:NP_066548.2|go:"GO:0036363"(transforming growth factor beta activation)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0046849"(bone remodeling)|go:"GO:0048251"(elastic fiber assembly)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0060430"(lung saccule development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:1902462"(positive regulation of mesenchymal stem cell proliferation)|go:"GO:2000741"(positive regulation of mesenchymal stem cell differentiation)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR017878|interpro:IPR018097|interpro:IPR026823|interpro:IPR036773|mint:Q9NS15|reactome:R-HSA-2129379|ensembl:ENSG00000168056(gene)|ensembl:ENST00000301873(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:QjQVU0uonSpj5vQU0pgzXuXmW3Y9606	rogid:wTlw1eFDbHiWYm9/2sgGxqK1uI49606	rigid:LAnZk+xJrzgoZZ19dLFj49aQADc	false	sufficient binding region:1-110	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49639	uniprotkb:Q14766	intact:EBI-740785|uniprotkb:O43363|uniprotkb:B2R8U7|uniprotkb:A4D184	intact:EBI-947693|uniprotkb:A1L3V1|uniprotkb:P22064|uniprotkb:Q53SD8|uniprotkb:Q53SF3|uniprotkb:Q53SG1|uniprotkb:Q59HF7|uniprotkb:Q8TD95|ensembl:ENSP00000386043	psi-mi:hxa1_human(display_long)|uniprotkb:Homeobox protein Hox-1F(gene name synonym)|uniprotkb:HOXA1(gene name)|psi-mi:HOXA1(display_short)|uniprotkb:HOX1F(gene name synonym)	psi-mi:ltbp1_human(display_long)|uniprotkb:LTBP1(gene name)|psi-mi:LTBP1(display_short)|uniprotkb:Transforming growth factor beta-1-binding protein 1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512546|imex:IM-28561-583	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005513.1|refseq:NP_705873.2|interpro:IPR001356(Homeobox)|interpro:IPR017970|interpro:IPR020479|interpro:IPR009057(Homeodomain-like)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007634"(optokinetic behavior)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0021599"(abducens nerve formation)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048702"(embryonic neurocranium morphogenesis)|go:"GO:0048839"(inner ear development)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050795"(regulation of behavior)|go:"GO:0050890"(cognition)|go:"GO:0050905"(neuromuscular process)|go:"GO:0060840"(artery development)|go:"GO:0060876"(semicircular canal formation)|go:"GO:0090102"(cochlea development)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|reactome:R-HSA-5617472|mint:P49639	refseq:NP_000618.3|refseq:NP_001159736.1|refseq:NP_001159737.1|refseq:NP_001159738.1|refseq:NP_996826.2|refseq:XP_011531155.1|dip:DIP-50011N|ensembl:ENSG00000049323(gene)|ensembl:ENST00000404816(transcript)|go:"GO:0001527"(microfibril)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035583"(sequestering of TGFbeta in extracellular matrix)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0050436"(microfibril binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:1901388"(regulation of transforming growth factor beta activation)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR017878|interpro:IPR018097|interpro:IPR026823|interpro:IPR036773|mint:Q14766|rcsb pdb:1KSQ|reactome:R-HSA-2129379|reactome:R-HSA-381426|reactome:R-HSA-8957275	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:QjQVU0uonSpj5vQU0pgzXuXmW3Y9606	rogid:OgHGfOcQWdQuLUT85Xg04lfggcs9606	rigid:23+PdcH1ZcNL6ANTJtPVBIkYhcU	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49639	uniprotkb:Q7Z4I7	intact:EBI-740785|uniprotkb:O43363|uniprotkb:B2R8U7|uniprotkb:A4D184	intact:EBI-6256404|ensembl:ENSP00000347240|uniprotkb:B4DMV1|uniprotkb:F5H6E6|uniprotkb:A6NLH0|uniprotkb:Q7Z4I6|uniprotkb:Q7Z4I8|uniprotkb:Q8NFE7|uniprotkb:Q9HA13|uniprotkb:Q7Z4I2	psi-mi:hxa1_human(display_long)|uniprotkb:Homeobox protein Hox-1F(gene name synonym)|uniprotkb:HOXA1(gene name)|psi-mi:HOXA1(display_short)|uniprotkb:HOX1F(gene name synonym)	psi-mi:lims2_human(display_long)|uniprotkb:LIMS2(gene name)|psi-mi:LIMS2(display_short)|uniprotkb:PINCH2(gene name synonym)|uniprotkb:LIM-like protein 2(gene name synonym)|uniprotkb:Particularly interesting new Cys-His protein 2(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512539|imex:IM-28561-1493	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005513.1|refseq:NP_705873.2|interpro:IPR001356(Homeobox)|interpro:IPR017970|interpro:IPR020479|interpro:IPR009057(Homeodomain-like)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007634"(optokinetic behavior)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0021599"(abducens nerve formation)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048702"(embryonic neurocranium morphogenesis)|go:"GO:0048839"(inner ear development)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050795"(regulation of behavior)|go:"GO:0050890"(cognition)|go:"GO:0050905"(neuromuscular process)|go:"GO:0060840"(artery development)|go:"GO:0060876"(semicircular canal formation)|go:"GO:0090102"(cochlea development)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|reactome:R-HSA-5617472|mint:P49639	ensembl:ENSG00000072163(gene)|ensembl:ENST00000355119(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0046872"(metal ion binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:2000178"(negative regulation of neural precursor cell proliferation)|go:"GO:2000346"(negative regulation of hepatocyte proliferation)|go:"GO:2001046"(positive regulation of integrin-mediated signaling pathway)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR017351(PINCH)|mint:Q7Z4I7|rcsb pdb:3IXE|reactome:R-HSA-446353|refseq:NP_001243471.1|refseq:NP_001129509.2|refseq:NP_001154875.1|refseq:NP_001154876.1|refseq:NP_060450.2	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:QjQVU0uonSpj5vQU0pgzXuXmW3Y9606	rogid:htxZoVjcjCf+1u1CWx75x5f3i6Y9606	rigid:Uet7OwCKprUHt7HLd/HKNENtQTo	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49639	uniprotkb:P55268	intact:EBI-740785|uniprotkb:O43363|uniprotkb:B2R8U7|uniprotkb:A4D184	intact:EBI-2529769|uniprotkb:Q16321|ensembl:ENSP00000307156|ensembl:ENSP00000388325	psi-mi:hxa1_human(display_long)|uniprotkb:Homeobox protein Hox-1F(gene name synonym)|uniprotkb:HOXA1(gene name)|psi-mi:HOXA1(display_short)|uniprotkb:HOX1F(gene name synonym)	psi-mi:lamb2_human(display_long)|uniprotkb:Laminin-4 subunit beta(gene name synonym)|uniprotkb:Laminin-7 subunit beta(gene name synonym)|uniprotkb:Laminin-9 subunit beta(gene name synonym)|uniprotkb:Laminin-11 subunit beta(gene name synonym)|uniprotkb:Laminin-14 subunit beta(gene name synonym)|uniprotkb:Laminin-15 subunit beta(gene name synonym)|uniprotkb:S-laminin subunit beta(gene name synonym)|uniprotkb:LAMB2(gene name)|psi-mi:LAMB2(display_short)|uniprotkb:LAMS(gene name synonym)|uniprotkb:Laminin-3 subunit beta(gene name synonym)|uniprotkb:Laminin B1s chain(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512532|imex:IM-28561-1693	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005513.1|refseq:NP_705873.2|interpro:IPR001356(Homeobox)|interpro:IPR017970|interpro:IPR020479|interpro:IPR009057(Homeodomain-like)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007634"(optokinetic behavior)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0021599"(abducens nerve formation)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048702"(embryonic neurocranium morphogenesis)|go:"GO:0048839"(inner ear development)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050795"(regulation of behavior)|go:"GO:0050890"(cognition)|go:"GO:0050905"(neuromuscular process)|go:"GO:0060840"(artery development)|go:"GO:0060876"(semicircular canal formation)|go:"GO:0090102"(cochlea development)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|reactome:R-HSA-5617472|mint:P49639	ensembl:ENSG00000172037(gene)|ensembl:ENST00000305544(transcript)|ensembl:ENST00000418109(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005608"(laminin-3 complex)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0007411"(axon guidance)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0007601"(visual perception)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009888"(tissue development)|go:"GO:0014002"(astrocyte development)|go:"GO:0014044"(Schwann cell development)|go:"GO:0016477"(cell migration)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043256"(laminin complex)|go:"GO:0043260"(laminin-11 complex)|go:"GO:0048677"(axon extension involved in regeneration)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070831"(basement membrane assembly)|go:"GO:0072249"(metanephric glomerular visceral epithelial cell development)|go:"GO:0072274"(metanephric glomerular basement membrane development)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002049(EGF-like, laminin)|interpro:IPR008211(Laminin, N-terminal)|interpro:IPR013015(Laminin IV)|mint:P55268|reactome:R-HSA-3000157|reactome:R-HSA-3000178|reactome:R-HSA-381426|reactome:R-HSA-8874081|reactome:R-HSA-8957275|reactome:R-HSA-3000171|refseq:NP_002283.3|refseq:XP_005265184.1|dip:DIP-42106N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:QjQVU0uonSpj5vQU0pgzXuXmW3Y9606	rogid:LY1lt2hyTcFN+x4GtvfzufChDF89606	rigid:FoT0AT9dS8cBUc0QFZJn4B7U3W0	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49639	uniprotkb:O15230	intact:EBI-740785|uniprotkb:O43363|uniprotkb:B2R8U7|uniprotkb:A4D184	intact:EBI-725060|uniprotkb:Q8WZA7|uniprotkb:Q9H1P1|uniprotkb:Q8TDF8|uniprotkb:Q5U4N9|ensembl:ENSP00000252999	psi-mi:hxa1_human(display_long)|uniprotkb:Homeobox protein Hox-1F(gene name synonym)|uniprotkb:HOXA1(gene name)|psi-mi:HOXA1(display_short)|uniprotkb:HOX1F(gene name synonym)	psi-mi:lama5_human(display_long)|uniprotkb:LAMA5(gene name)|psi-mi:LAMA5(display_short)|uniprotkb:KIAA0533(gene name synonym)|uniprotkb:KIAA1907(gene name synonym)|uniprotkb:Laminin-10 subunit alpha(gene name synonym)|uniprotkb:Laminin-11 subunit alpha(gene name synonym)|uniprotkb:Laminin-15 subunit alpha(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512525|imex:IM-28561-1491	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005513.1|refseq:NP_705873.2|interpro:IPR001356(Homeobox)|interpro:IPR017970|interpro:IPR020479|interpro:IPR009057(Homeodomain-like)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007634"(optokinetic behavior)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0021599"(abducens nerve formation)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048702"(embryonic neurocranium morphogenesis)|go:"GO:0048839"(inner ear development)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050795"(regulation of behavior)|go:"GO:0050890"(cognition)|go:"GO:0050905"(neuromuscular process)|go:"GO:0060840"(artery development)|go:"GO:0060876"(semicircular canal formation)|go:"GO:0090102"(cochlea development)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|reactome:R-HSA-5617472|mint:P49639	refseq:NP_005551.3|ensembl:ENSG00000130702(gene)|ensembl:ENST00000252999(transcript)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001942"(hair follicle development)|go:"GO:0005178"(integrin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005610"(laminin-5 complex)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007517"(muscle organ development)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009888"(tissue development)|go:"GO:0016331"(morphogenesis of embryonic epithelium)|go:"GO:0016477"(cell migration)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030324"(lung development)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043259"(laminin-10 complex)|go:"GO:0043260"(laminin-11 complex)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0060271"(cilium assembly)|go:"GO:0060445"(branching involved in salivary gland morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR000034(Laminin B)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR001791(Laminin G)|interpro:IPR002049(EGF-like, laminin)|interpro:IPR008211(Laminin, N-terminal)|interpro:IPR009254(Laminin I)|interpro:IPR010307(Laminin II)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|mint:O15230|rcsb pdb:5XAU|rcsb pdb:7CEC|reactome:R-HSA-1474228|reactome:R-HSA-3000157|reactome:R-HSA-3000171|reactome:R-HSA-3000178|reactome:R-HSA-6785807|reactome:R-HSA-8874081	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:QjQVU0uonSpj5vQU0pgzXuXmW3Y9606	rogid:rSTl5zwwQKcbd20buKGffFtl3jI9606	rigid:FUxIvmfAUq7eEAO8PLzn9vC4SOI	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49639	uniprotkb:Q99447	intact:EBI-740785|uniprotkb:O43363|uniprotkb:B2R8U7|uniprotkb:A4D184	intact:EBI-750317|uniprotkb:Q96G08|uniprotkb:Q6IBM3|uniprotkb:B7Z7A5|uniprotkb:F5H8B1|uniprotkb:B7ZAS0|ensembl:ENSP00000439245	psi-mi:hxa1_human(display_long)|uniprotkb:Homeobox protein Hox-1F(gene name synonym)|uniprotkb:HOXA1(gene name)|psi-mi:HOXA1(display_short)|uniprotkb:HOX1F(gene name synonym)	psi-mi:pcy2_human(display_long)|uniprotkb:Phosphorylethanolamine transferase(gene name synonym)|uniprotkb:"CTP:phosphoethanolamine cytidylyltransferase"(gene name synonym)|uniprotkb:PCYT2(gene name)|psi-mi:PCYT2(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512659|imex:IM-28561-131	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005513.1|refseq:NP_705873.2|interpro:IPR001356(Homeobox)|interpro:IPR017970|interpro:IPR020479|interpro:IPR009057(Homeodomain-like)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007634"(optokinetic behavior)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0021599"(abducens nerve formation)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048702"(embryonic neurocranium morphogenesis)|go:"GO:0048839"(inner ear development)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050795"(regulation of behavior)|go:"GO:0050890"(cognition)|go:"GO:0050905"(neuromuscular process)|go:"GO:0060840"(artery development)|go:"GO:0060876"(semicircular canal formation)|go:"GO:0090102"(cochlea development)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|reactome:R-HSA-5617472|mint:P49639	refseq:NP_001243364.1|refseq:NP_002852.1|refseq:NP_001171846.1|refseq:NP_001269132.1|refseq:NP_001269133.1|refseq:XP_016880400.1|ensembl:ENSG00000185813(gene)|ensembl:ENST00000538936(transcript)|go:"GO:0004306"(ethanolamine-phosphate cytidylyltransferase activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006646"(phosphatidylethanolamine biosynthetic process)|go:"GO:0008654"(phospholipid biosynthetic process)|interpro:IPR004821(Cytidyltransferase-related)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR041723|interpro:IPR044608|mint:Q99447|rcsb pdb:3ELB|rcsb pdb:4XSV|reactome:R-HSA-1483213	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:QjQVU0uonSpj5vQU0pgzXuXmW3Y9606	rogid:G5aZQtq6KMWvAqOUxanL7SLNvVc9606	rigid:iXsfK21InDOl4irAEPktH8BK7vA	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49639	uniprotkb:P28799	intact:EBI-740785|uniprotkb:O43363|uniprotkb:B2R8U7|uniprotkb:A4D184	intact:EBI-747754|uniprotkb:P23781|uniprotkb:P23782|uniprotkb:P23783|uniprotkb:P23784|uniprotkb:Q9BWE7|uniprotkb:Q9UCH0|ensembl:ENSP00000053867|uniprotkb:Q53Y88|uniprotkb:Q540U8|uniprotkb:D3DX55|uniprotkb:Q53HQ8|uniprotkb:Q9H8S1	psi-mi:hxa1_human(display_long)|uniprotkb:Homeobox protein Hox-1F(gene name synonym)|uniprotkb:HOXA1(gene name)|psi-mi:HOXA1(display_short)|uniprotkb:HOX1F(gene name synonym)	psi-mi:grn_human(display_long)|uniprotkb:Proepithelin(gene name synonym)|uniprotkb:GRN(gene name)|psi-mi:GRN(display_short)|uniprotkb:Acrogranin(gene name synonym)|uniprotkb:Epithelin precursor(gene name synonym)|uniprotkb:Glycoprotein of 88 Kda(gene name synonym)|uniprotkb:Granulin precursor(gene name synonym)|uniprotkb:PC cell-derived growth factor(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512500|imex:IM-28561-1005	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005513.1|refseq:NP_705873.2|interpro:IPR001356(Homeobox)|interpro:IPR017970|interpro:IPR020479|interpro:IPR009057(Homeodomain-like)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007634"(optokinetic behavior)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0021599"(abducens nerve formation)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048702"(embryonic neurocranium morphogenesis)|go:"GO:0048839"(inner ear development)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050795"(regulation of behavior)|go:"GO:0050890"(cognition)|go:"GO:0050905"(neuromuscular process)|go:"GO:0060840"(artery development)|go:"GO:0060876"(semicircular canal formation)|go:"GO:0090102"(cochlea development)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|reactome:R-HSA-5617472|mint:P49639	refseq:NP_002078.1|ensembl:ENSG00000030582(gene)|ensembl:ENST00000053867(transcript)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0003723"(RNA binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007040"(lysosome organization)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048680"(positive regulation of axon regeneration)|refseq:XP_005257310.1|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0060266"(negative regulation of respiratory burst involved in inflammatory response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0106016"(positive regulation of inflammatory response to wounding)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1902564"(negative regulation of neutrophil activation)|go:"GO:1903334"(positive regulation of protein folding)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1905247"(positive regulation of aspartic-type peptidase activity)|go:"GO:1905673"(positive regulation of lysosome organization)|interpro:IPR000118(Granulin)|interpro:IPR037277|interpro:IPR039036|mint:P28799|rcsb pdb:1G26|rcsb pdb:2JYE|rcsb pdb:2JYT|rcsb pdb:2JYU|rcsb pdb:2JYV|rcsb pdb:6NUG|reactome:R-HSA-6798695|dip:DIP-41742N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:QjQVU0uonSpj5vQU0pgzXuXmW3Y9606	rogid:SaujQCj7wHfPYunGzgTgG+jQgA89606	rigid:J28DVwJnmA+mrYDqEi9bFaGi6V8	false	sufficient binding region:1-110	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49639	uniprotkb:Q02818	intact:EBI-740785|uniprotkb:O43363|uniprotkb:B2R8U7|uniprotkb:A4D184	intact:EBI-2622179|uniprotkb:Q7Z4J7|uniprotkb:B2RD64|uniprotkb:Q9BUR1|uniprotkb:Q15838|intact:EBI-28978015|ensembl:ENSP00000385211|ensembl:ENSP00000385923	psi-mi:hxa1_human(display_long)|uniprotkb:Homeobox protein Hox-1F(gene name synonym)|uniprotkb:HOXA1(gene name)|psi-mi:HOXA1(display_short)|uniprotkb:HOX1F(gene name synonym)	psi-mi:nucb1_human(display_long)|uniprotkb:NUC(gene name synonym)|uniprotkb:CALNUC(gene name synonym)|uniprotkb:NUCB1(gene name)|psi-mi:NUCB1(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512645|imex:IM-28561-585	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005513.1|refseq:NP_705873.2|interpro:IPR001356(Homeobox)|interpro:IPR017970|interpro:IPR020479|interpro:IPR009057(Homeodomain-like)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007634"(optokinetic behavior)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0021599"(abducens nerve formation)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048702"(embryonic neurocranium morphogenesis)|go:"GO:0048839"(inner ear development)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050795"(regulation of behavior)|go:"GO:0050890"(cognition)|go:"GO:0050905"(neuromuscular process)|go:"GO:0060840"(artery development)|go:"GO:0060876"(semicircular canal formation)|go:"GO:0090102"(cochlea development)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|reactome:R-HSA-5617472|mint:P49639	ensembl:ENSP00000385923|ensembl:ENSP00000385211|refseq:NP_006175.2|refseq:XP_016882334.1|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072718"(response to cisplatin)|go:"GO:0090498"(extrinsic component of Golgi membrane)|go:"GO:0098547"(lumenal side of Golgi membrane)|go:"GO:1903533"(regulation of protein targeting)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR040250|interpro:IPR040253|mint:Q02818|rcsb pdb:1SNL|reactome:R-HSA-381426|reactome:R-HSA-8957275|ensembl:ENSG00000104805(gene)|ensembl:ENST00000405315(transcript)|ensembl:ENST00000407032(transcript)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0003677"(DNA binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:QjQVU0uonSpj5vQU0pgzXuXmW3Y9606	rogid:exoVYPq5+NxEpgkm/gAQay/Uwuk9606	rigid:8VA503sNQ1KwH7bw7kBEFpvkGRI	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49639	uniprotkb:Q9ULT6	intact:EBI-740785|uniprotkb:O43363|uniprotkb:B2R8U7|uniprotkb:A4D184	intact:EBI-949772|ensembl:ENSP00000443824|uniprotkb:B3KU18|uniprotkb:Q6ICH1|uniprotkb:Q6NTF8|uniprotkb:Q8WU18|intact:EBI-2130135	psi-mi:hxa1_human(display_long)|uniprotkb:Homeobox protein Hox-1F(gene name synonym)|uniprotkb:HOXA1(gene name)|psi-mi:HOXA1(display_short)|uniprotkb:HOX1F(gene name synonym)	psi-mi:znrf3_human(display_long)|uniprotkb:RING finger protein 203(gene name synonym)|uniprotkb:ZNRF3(gene name)|psi-mi:ZNRF3(display_short)|uniprotkb:KIAA1133(gene name synonym)|uniprotkb:RNF203(gene name synonym)|uniprotkb:Zinc/RING finger protein 3(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase ZNRF3(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512739|imex:IM-28561-1217	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005513.1|refseq:NP_705873.2|interpro:IPR001356(Homeobox)|interpro:IPR017970|interpro:IPR020479|interpro:IPR009057(Homeodomain-like)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007634"(optokinetic behavior)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0021599"(abducens nerve formation)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048702"(embryonic neurocranium morphogenesis)|go:"GO:0048839"(inner ear development)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050795"(regulation of behavior)|go:"GO:0050890"(cognition)|go:"GO:0050905"(neuromuscular process)|go:"GO:0060840"(artery development)|go:"GO:0060876"(semicircular canal formation)|go:"GO:0090102"(cochlea development)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|reactome:R-HSA-5617472|mint:P49639	refseq:NP_001193927.1|refseq:NP_115549.2|ensembl:ENSG00000183579(gene)|ensembl:ENST00000544604(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005109"(frizzled binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0038018"(Wnt receptor catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0060173"(limb development)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0072089"(stem cell proliferation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:2000051"(negative regulation of non-canonical Wnt signaling pathway)|go:"GO:2000095"(regulation of Wnt signaling pathway, planar cell polarity pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR040700|mint:Q9ULT6|reactome:R-HSA-4641263|dip:DIP-50030N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:QjQVU0uonSpj5vQU0pgzXuXmW3Y9606	rogid:NI0yNKDLOyZmCO7OmzAa8VPQzNM9606	rigid:+fdarmQGqQS6do4E/0gH4VTWBuc	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49639	uniprotkb:P04275	intact:EBI-740785|uniprotkb:O43363|uniprotkb:B2R8U7|uniprotkb:A4D184	intact:EBI-981819|uniprotkb:Q8TCE8|uniprotkb:Q99806|ensembl:ENSP00000261405	psi-mi:hxa1_human(display_long)|uniprotkb:Homeobox protein Hox-1F(gene name synonym)|uniprotkb:HOXA1(gene name)|psi-mi:HOXA1(display_short)|uniprotkb:HOX1F(gene name synonym)	psi-mi:vwf_human(display_long)|uniprotkb:VWF(gene name)|psi-mi:VWF(display_short)|uniprotkb:F8VWF(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512732|imex:IM-28561-1215	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005513.1|refseq:NP_705873.2|interpro:IPR001356(Homeobox)|interpro:IPR017970|interpro:IPR020479|interpro:IPR009057(Homeodomain-like)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007634"(optokinetic behavior)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0021599"(abducens nerve formation)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048702"(embryonic neurocranium morphogenesis)|go:"GO:0048839"(inner ear development)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050795"(regulation of behavior)|go:"GO:0050890"(cognition)|go:"GO:0050905"(neuromuscular process)|go:"GO:0060840"(artery development)|go:"GO:0060876"(semicircular canal formation)|go:"GO:0090102"(cochlea development)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|reactome:R-HSA-5617472|mint:P49639	refseq:NP_000543.2|ensembl:ENSG00000110799(gene)|ensembl:ENST00000261405(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007155"(cell adhesion)|go:"GO:0007596"(blood coagulation)|go:"GO:0007599"(hemostasis)|go:"GO:0009611"(response to wounding)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0030168"(platelet activation)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0033093"(Weibel-Palade body)|go:"GO:0042802"(identical protein binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051087"(chaperone binding)|dip:DIP-29667N|reactome:R-HSA-9672391|reactome:R-HSA-9672393|rcsb pdb:5BV8|rcsb pdb:6FWN|rcsb pdb:6N29|rcsb pdb:7KWO|go:"GO:0062023"(collagen-containing extracellular matrix)|reactome:R-HSA-114608|reactome:R-HSA-140837|reactome:R-HSA-216083|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-430116|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-75892|reactome:R-HSA-76009|rcsb pdb:4NT5|reactome:R-HSA-9649948|reactome:R-HSA-9656223|go:"GO:1902533"(positive regulation of intracellular signal transduction)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR001846(von Willebrand factor, type D)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR002919(Protease inhibitor I8, cysteine-rich trypsin inhibitor-like)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR014853(Region of unknown function DUF1787)|interpro:IPR032361|interpro:IPR036084|interpro:IPR036465|interpro:IPR037578|mint:P04275|rcsb pdb:1AO3|rcsb pdb:1ATZ|rcsb pdb:1AUQ|rcsb pdb:1FE8|rcsb pdb:1FNS|rcsb pdb:1IJB|rcsb pdb:1IJK|rcsb pdb:1M10|rcsb pdb:1OAK|rcsb pdb:1SQ0|rcsb pdb:1U0N|rcsb pdb:1UEX|rcsb pdb:2ADF|rcsb pdb:2MHP|rcsb pdb:2MHQ|rcsb pdb:3GXB|rcsb pdb:3HXO|rcsb pdb:3HXQ|rcsb pdb:3PPV|go:"GO:0070062"(extracellular exosome)|rcsb pdb:3PPW|rcsb pdb:3PPX|rcsb pdb:3PPY|rcsb pdb:3ZQK|rcsb pdb:4C29|rcsb pdb:4C2A|rcsb pdb:4C2B|rcsb pdb:4DMU	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:QjQVU0uonSpj5vQU0pgzXuXmW3Y9606	rogid:yeGxC2SyyvUZ3hNciww1o8TmY5Q9606	rigid:gwLFXbkmR/38d0gQ6DSw725JE+o	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49639	uniprotkb:Q96DN2	intact:EBI-740785|uniprotkb:O43363|uniprotkb:B2R8U7|uniprotkb:A4D184	intact:EBI-2850497|uniprotkb:Q86WK8|uniprotkb:A5PKV0|uniprotkb:Q7Z7L6|ensembl:ENSP00000334186	psi-mi:hxa1_human(display_long)|uniprotkb:Homeobox protein Hox-1F(gene name synonym)|uniprotkb:HOXA1(gene name)|psi-mi:HOXA1(display_short)|uniprotkb:HOX1F(gene name synonym)	psi-mi:vwce_human(display_long)|uniprotkb:VWCE(gene name)|psi-mi:VWCE(display_short)|uniprotkb:URG11(gene name synonym)|uniprotkb:HBV X protein up-regulated gene 11 protein(gene name synonym)|uniprotkb:HBxAg up-regulated gene 11 protein(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512725|imex:IM-28561-783	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005513.1|refseq:NP_705873.2|interpro:IPR001356(Homeobox)|interpro:IPR017970|interpro:IPR020479|interpro:IPR009057(Homeodomain-like)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007634"(optokinetic behavior)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0021599"(abducens nerve formation)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048702"(embryonic neurocranium morphogenesis)|go:"GO:0048839"(inner ear development)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050795"(regulation of behavior)|go:"GO:0050890"(cognition)|go:"GO:0050905"(neuromuscular process)|go:"GO:0060840"(artery development)|go:"GO:0060876"(semicircular canal formation)|go:"GO:0090102"(cochlea development)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|reactome:R-HSA-5617472|mint:P49639	refseq:NP_689931.2|ensembl:ENSG00000167992(gene)|ensembl:ENST00000335613(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0098586"(cellular response to virus)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR018097|mint:Q96DN2	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:QjQVU0uonSpj5vQU0pgzXuXmW3Y9606	rogid:iBs6xSgpnuM95cf8NssaHvB9bSI9606	rigid:goxFFbJeG3W4NZGhB4bBuvZA1xA	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49639	uniprotkb:O43294	intact:EBI-740785|uniprotkb:O43363|uniprotkb:B2R8U7|uniprotkb:A4D184	intact:EBI-1051449|uniprotkb:Q9BPW3|uniprotkb:Q9Y2V5|uniprotkb:B2R8D5|ensembl:ENSP00000378332	psi-mi:hxa1_human(display_long)|uniprotkb:Homeobox protein Hox-1F(gene name synonym)|uniprotkb:HOXA1(gene name)|psi-mi:HOXA1(display_short)|uniprotkb:HOX1F(gene name synonym)	psi-mi:tgfi1_human(display_long)|uniprotkb:TGFB1I1(gene name)|psi-mi:TGFB1I1(display_short)|uniprotkb:ARA55(gene name synonym)|uniprotkb:Hydrogen peroxide-inducible clone 5 protein(gene name synonym)|uniprotkb:Androgen receptor-associated protein of 55 kDa(gene name synonym)|uniprotkb:Androgen receptor coactivator 55 kDa protein(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512718|imex:IM-28561-1501	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005513.1|refseq:NP_705873.2|interpro:IPR001356(Homeobox)|interpro:IPR017970|interpro:IPR020479|interpro:IPR009057(Homeodomain-like)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007634"(optokinetic behavior)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0021599"(abducens nerve formation)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048702"(embryonic neurocranium morphogenesis)|go:"GO:0048839"(inner ear development)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050795"(regulation of behavior)|go:"GO:0050890"(cognition)|go:"GO:0050905"(neuromuscular process)|go:"GO:0060840"(artery development)|go:"GO:0060876"(semicircular canal formation)|go:"GO:0090102"(cochlea development)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|reactome:R-HSA-5617472|mint:P49639	refseq:NP_001035919.1|refseq:NP_001158191.1|refseq:NP_057011.2|ensembl:ENSP00000355117|ensembl:ENST00000394858|ensembl:ENSP00000378327|ensembl:ENSP00000378332|ensembl:ENST00000567607|ensembl:ENSP00000457586|ensembl:ENST00000361773|ensembl:ENSG00000140682(gene)|ensembl:ENST00000394863(transcript)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009408"(response to heat)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016331"(morphogenesis of embryonic epithelium)|go:"GO:0016363"(nuclear matrix)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0048495"(Roundabout binding)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0070411"(I-SMAD binding)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR017305(Leupaxin)|mint:O43294|dip:DIP-5931N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:QjQVU0uonSpj5vQU0pgzXuXmW3Y9606	rogid:ekkGbwdFenBhBn0HzJjd4Szi61U9606	rigid:9JrmXX5L3Aqq7siCEYpqt4MWsNc	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49639	uniprotkb:Q16650	intact:EBI-740785|uniprotkb:O43363|uniprotkb:B2R8U7|uniprotkb:A4D184	intact:EBI-1047158|ensembl:ENSP00000374205|uniprotkb:Q14DC5|uniprotkb:Q53TH0|uniprotkb:B2R6G5|uniprotkb:Q56A81|uniprotkb:B0AZS4	psi-mi:hxa1_human(display_long)|uniprotkb:Homeobox protein Hox-1F(gene name synonym)|uniprotkb:HOXA1(gene name)|psi-mi:HOXA1(display_short)|uniprotkb:HOX1F(gene name synonym)	psi-mi:tbr1_human(display_long)|uniprotkb:TES-56(gene name synonym)|uniprotkb:TBR1(gene name)|psi-mi:TBR1(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512709|imex:IM-28561-587	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005513.1|refseq:NP_705873.2|interpro:IPR001356(Homeobox)|interpro:IPR017970|interpro:IPR020479|interpro:IPR009057(Homeodomain-like)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007634"(optokinetic behavior)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0021599"(abducens nerve formation)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048702"(embryonic neurocranium morphogenesis)|go:"GO:0048839"(inner ear development)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050795"(regulation of behavior)|go:"GO:0050890"(cognition)|go:"GO:0050905"(neuromuscular process)|go:"GO:0060840"(artery development)|go:"GO:0060876"(semicircular canal formation)|go:"GO:0090102"(cochlea development)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|reactome:R-HSA-5617472|mint:P49639	refseq:NP_006584.1|ensembl:ENSG00000136535(gene)|ensembl:ENST00000389554(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1902667"(regulation of axon guidance)|go:"GO:0001708"(cell fate specification)|go:"GO:0001947"(heart looping)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007420"(brain development)|go:"GO:0010092"(specification of animal organ identity)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021764"(amygdala development)|go:"GO:0021902"(commitment of neuronal cell to specific neuron type in forebrain)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030902"(hindbrain development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR001699(Transcription factor, T-box)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR018186|interpro:IPR032385|interpro:IPR036960|mint:Q16650	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:QjQVU0uonSpj5vQU0pgzXuXmW3Y9606	rogid:qD1euHkX/welvC2klFM95IiAiWE9606	rigid:gqp4UOYXbZS3lnzrxGo7H7Wd/9o	false	sufficient binding region:1-110	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49639	uniprotkb:P14618	intact:EBI-740785|uniprotkb:O43363|uniprotkb:B2R8U7|uniprotkb:A4D184	intact:EBI-353408|uniprotkb:A6NFK3|uniprotkb:P14786|uniprotkb:Q53GK4|uniprotkb:Q96E76|uniprotkb:Q9BWB5|uniprotkb:Q9UPF2|uniprotkb:B2R5N8|uniprotkb:B3KRY0|uniprotkb:B4DFX8|uniprotkb:Q9UCV6|intact:EBI-2555890|uniprotkb:B4DUU6|ensembl:ENSP00000334983	psi-mi:hxa1_human(display_long)|uniprotkb:Homeobox protein Hox-1F(gene name synonym)|uniprotkb:HOXA1(gene name)|psi-mi:HOXA1(display_short)|uniprotkb:HOX1F(gene name synonym)	psi-mi:kpym_human(display_long)|uniprotkb:PKM(gene name)|psi-mi:PKM(display_short)|uniprotkb:Cytosolic thyroid hormone-binding protein(gene name synonym)|uniprotkb:OIP3(gene name synonym)|uniprotkb:Opa-interacting protein 3(gene name synonym)|uniprotkb:PK2(gene name synonym)|uniprotkb:PK3(gene name synonym)|uniprotkb:PKM2(gene name synonym)|uniprotkb:Pyruvate kinase 2/3(gene name synonym)|uniprotkb:Pyruvate kinase muscle isozyme(gene name synonym)|uniprotkb:Thyroid hormone-binding protein 1(gene name synonym)|uniprotkb:Tumor M2-PK(gene name synonym)|uniprotkb:p58(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512667|imex:IM-28561-133	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005513.1|refseq:NP_705873.2|interpro:IPR001356(Homeobox)|interpro:IPR017970|interpro:IPR020479|interpro:IPR009057(Homeodomain-like)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007634"(optokinetic behavior)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0021599"(abducens nerve formation)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048702"(embryonic neurocranium morphogenesis)|go:"GO:0048839"(inner ear development)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050795"(regulation of behavior)|go:"GO:0050890"(cognition)|go:"GO:0050905"(neuromuscular process)|go:"GO:0060840"(artery development)|go:"GO:0060876"(semicircular canal formation)|go:"GO:0090102"(cochlea development)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|reactome:R-HSA-5617472|mint:P49639	refseq:NP_001193725.1|refseq:NP_001193727.1|refseq:NP_001193728.1|refseq:NP_002645.3|refseq:NP_872270.1|refseq:NP_872271.1|refseq:NP_001193726.1|refseq:NP_001303247.1|refseq:XP_005254502.1|dip:DIP-31273N|ensembl:ENSG00000067225(gene)|ensembl:ENST00000335181(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004743"(pyruvate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0006096"(glycolytic process)|go:"GO:0012501"(programmed cell death)|go:"GO:0016301"(kinase activity)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031982"(vesicle)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0045296"(cadherin binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2000767"(positive regulation of cytoplasmic translation)|interpro:IPR001697(Pyruvate kinase)|interpro:IPR011037(Pyruvate kinase, beta-barrel-like)|interpro:IPR015793(Pyruvate kinase, barrel)|interpro:IPR015795(Pyruvate kinase, C-terminal-like)|interpro:IPR015806(Pyruvate kinase, beta-barrel)|interpro:IPR015813(Pyruvate/Phosphoenolpyruvate kinase, catalytic core)|interpro:IPR018209|interpro:IPR036918|interpro:IPR040442|mint:P14618|rcsb pdb:1T5A|rcsb pdb:1ZJH|rcsb pdb:3BJF|rcsb pdb:3BJT|rcsb pdb:3G2G|rcsb pdb:3GQY|rcsb pdb:3GR4|rcsb pdb:3H6O|rcsb pdb:3ME3|rcsb pdb:3SRD|rcsb pdb:3SRF|rcsb pdb:3U2Z|rcsb pdb:4B2D|rcsb pdb:4FXF|rcsb pdb:4FXJ|rcsb pdb:4G1N|rcsb pdb:4JPG|rcsb pdb:4QG6|rcsb pdb:4QG8|rcsb pdb:4QG9|rcsb pdb:4QGC|rcsb pdb:4RPP|rcsb pdb:4WJ8|rcsb pdb:4YJ5|rcsb pdb:5X0I|rcsb pdb:5X1V|rcsb pdb:5X1W|rcsb pdb:6B6U|rcsb pdb:6GG3|rcsb pdb:6GG4|rcsb pdb:6GG5|rcsb pdb:6GG6|rcsb pdb:6JFB|rcsb pdb:6NU1|rcsb pdb:6NU5|rcsb pdb:6NUB|rcsb pdb:6TTF|rcsb pdb:6TTH|rcsb pdb:6TTI|rcsb pdb:6TTQ|rcsb pdb:6V74|rcsb pdb:3SRH|rcsb pdb:6V75|rcsb pdb:6V76|rcsb pdb:6WP3|rcsb pdb:6WP4|rcsb pdb:6WP5|rcsb pdb:6WP6|reactome:R-HSA-6798695|reactome:R-HSA-70171|refseq:XP_016877802.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:QjQVU0uonSpj5vQU0pgzXuXmW3Y9606	rogid:dDaoXCaqd0x6qFSElvngHusttuk9606	rigid:UhagVQOiekV3LVqaGeg8B8cYT6M	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49639	uniprotkb:O94813	intact:EBI-740785|uniprotkb:O43363|uniprotkb:B2R8U7|uniprotkb:A4D184	intact:EBI-1236865|uniprotkb:O95710|uniprotkb:Q17RU3|uniprotkb:Q9Y5Q7|uniprotkb:B7ZLR5|uniprotkb:A0A0A6YYB8|ensembl:ENSP00000422591	psi-mi:hxa1_human(display_long)|uniprotkb:Homeobox protein Hox-1F(gene name synonym)|uniprotkb:HOXA1(gene name)|psi-mi:HOXA1(display_short)|uniprotkb:HOX1F(gene name synonym)	psi-mi:slit2_human(display_long)|uniprotkb:SLIT2(gene name)|psi-mi:SLIT2(display_short)|uniprotkb:SLIL3(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512695|imex:IM-28561-135	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005513.1|refseq:NP_705873.2|interpro:IPR001356(Homeobox)|interpro:IPR017970|interpro:IPR020479|interpro:IPR009057(Homeodomain-like)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007634"(optokinetic behavior)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0021599"(abducens nerve formation)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048702"(embryonic neurocranium morphogenesis)|go:"GO:0048839"(inner ear development)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050795"(regulation of behavior)|go:"GO:0050890"(cognition)|go:"GO:0050905"(neuromuscular process)|go:"GO:0060840"(artery development)|go:"GO:0060876"(semicircular canal formation)|go:"GO:0090102"(cochlea development)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|reactome:R-HSA-5617472|mint:P49639	refseq:NP_001276064.1|refseq:NP_001276065.1|refseq:NP_004778.1|dip:DIP-38198N|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0005095"(GTPase inhibitor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0035385"(Roundabout signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007411"(axon guidance)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008201"(heparin binding)|go:"GO:0009986"(cell surface)|go:"GO:0010593"(negative regulation of lamellipodium assembly)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016020"(membrane)|go:"GO:0021836"(chemorepulsion involved in postnatal olfactory bulb interneuron migration)|go:"GO:0021972"(corticospinal neuron axon guidance through spinal cord)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043237"(laminin-1 binding)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0048495"(Roundabout binding)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048846"(axon extension involved in axon guidance)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0050929"(induction of negative chemotaxis)|go:"GO:0051058"(negative regulation of small GTPase mediated signal transduction)|go:"GO:0051414"(response to cortisol)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0061364"(apoptotic process involved in luteolysis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070100"(negative regulation of chemokine-mediated signaling pathway)|go:"GO:0071504"(cellular response to heparin)|go:"GO:0071672"(negative regulation of smooth muscle cell chemotaxis)|go:"GO:0071676"(negative regulation of mononuclear cell migration)|go:"GO:0090024"(negative regulation of neutrophil chemotaxis)|go:"GO:0090027"(negative regulation of monocyte chemotaxis)|go:"GO:0090260"(negative regulation of retinal ganglion cell axon guidance)|go:"GO:0090288"(negative regulation of cellular response to growth factor stimulus)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001791(Laminin G)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR003645(Follistatin-like, N-terminal)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR018097|interpro:IPR032675|mint:O94813|rcsb pdb:2V70|rcsb pdb:2V9S|rcsb pdb:2V9T|rcsb pdb:2WFH|reactome:R-HSA-373752|reactome:R-HSA-376176|reactome:R-HSA-428540|reactome:R-HSA-428542|reactome:R-HSA-428543|reactome:R-HSA-428890|reactome:R-HSA-8985586|reactome:R-HSA-9010553|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001611(Leucine-rich repeat)|ensembl:ENSG00000145147(gene)|ensembl:ENST00000504154(transcript)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0002689"(negative regulation of leukocyte chemotaxis)|go:"GO:0003180"(aortic valve morphogenesis)	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:QjQVU0uonSpj5vQU0pgzXuXmW3Y9606	rogid:25Wc98dEfv1yROTD5pUtyQ+LWN89606	rigid:/YayoPFjYXGGhbbxyqf/zIcHxuE	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49639	uniprotkb:O75093	intact:EBI-740785|uniprotkb:O43363|uniprotkb:B2R8U7|uniprotkb:A4D184	intact:EBI-947791|uniprotkb:Q8WWZ2|uniprotkb:Q9UIL7|uniprotkb:Q5T0V1|ensembl:ENSP00000266058	psi-mi:hxa1_human(display_long)|uniprotkb:Homeobox protein Hox-1F(gene name synonym)|uniprotkb:HOXA1(gene name)|psi-mi:HOXA1(display_short)|uniprotkb:HOX1F(gene name synonym)	psi-mi:slit1_human(display_long)|uniprotkb:Multiple epidermal growth factor-like domains protein 4(gene name synonym)|uniprotkb:SLIT1(gene name)|psi-mi:SLIT1(display_short)|uniprotkb:KIAA0813(gene name synonym)|uniprotkb:MEGF4(gene name synonym)|uniprotkb:SLIL1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512688|imex:IM-28561-1023	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005513.1|refseq:NP_705873.2|interpro:IPR001356(Homeobox)|interpro:IPR017970|interpro:IPR020479|interpro:IPR009057(Homeodomain-like)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007634"(optokinetic behavior)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0021599"(abducens nerve formation)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048702"(embryonic neurocranium morphogenesis)|go:"GO:0048839"(inner ear development)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050795"(regulation of behavior)|go:"GO:0050890"(cognition)|go:"GO:0050905"(neuromuscular process)|go:"GO:0060840"(artery development)|go:"GO:0060876"(semicircular canal formation)|go:"GO:0090102"(cochlea development)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|reactome:R-HSA-5617472|mint:P49639	refseq:NP_003052.2|ensembl:ENSG00000187122(gene)|ensembl:ENST00000266058(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0007097"(nuclear migration)|go:"GO:0007411"(axon guidance)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008201"(heparin binding)|go:"GO:0022028"(tangential migration from the subventricular zone to the olfactory bulb)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0033563"(dorsal/ventral axon guidance)|go:"GO:0048495"(Roundabout binding)|go:"GO:0048846"(axon extension involved in axon guidance)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0051964"(negative regulation of synapse assembly)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001791(Laminin G)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR003645(Follistatin-like, N-terminal)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR018097|interpro:IPR032675|mint:O75093|reactome:R-HSA-373752|reactome:R-HSA-376176|reactome:R-HSA-428542|reactome:R-HSA-8985801|reactome:R-HSA-9010553	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:QjQVU0uonSpj5vQU0pgzXuXmW3Y9606	rogid:CLzbkIsFRc56n2LK/zvue0dA+4Q9606	rigid:HfmfqaWeSFKLxM4gyeO18lyZNSo	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q15032	uniprotkb:P49639	intact:EBI-2267290|uniprotkb:Q8IW32|uniprotkb:G5E9G8|uniprotkb:A8K1V0|uniprotkb:B3KXQ9|uniprotkb:E9PBB4|uniprotkb:E9PG42|ensembl:ENSP00000264160	intact:EBI-740785|uniprotkb:O43363|uniprotkb:B2R8U7|uniprotkb:A4D184	psi-mi:r3hd1_human(display_long)|uniprotkb:R3HDM1(gene name)|psi-mi:R3HDM1(display_short)|uniprotkb:KIAA0029(gene name synonym)|uniprotkb:R3HDM(gene name synonym)	psi-mi:hxa1_human(display_long)|uniprotkb:Homeobox protein Hox-1F(gene name synonym)|uniprotkb:HOXA1(gene name)|psi-mi:HOXA1(display_short)|uniprotkb:HOX1F(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512681|imex:IM-28561-1499	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001269727.1|refseq:NP_001269728.1|refseq:NP_001269729.1|refseq:XP_006712452.1|refseq:XP_016859207.1|refseq:NP_056176.2|ensembl:ENSP00000264160|ensembl:ENST00000409478|ensembl:ENSP00000386457|ensembl:ENST00000409606|ensembl:ENSP00000387010|ensembl:ENST00000410054|ensembl:ENSP00000386877|ensembl:ENST00000628915|ensembl:ENSP00000486837|ensembl:ENSG00000048991(gene)|ensembl:ENST00000264160(transcript)|go:"GO:0003723"(RNA binding)|interpro:IPR001374(Single-stranded nucleic acid binding R3H)|interpro:IPR024771|interpro:IPR036867|mint:Q15032	refseq:NP_005513.1|refseq:NP_705873.2|interpro:IPR001356(Homeobox)|interpro:IPR017970|interpro:IPR020479|interpro:IPR009057(Homeodomain-like)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007634"(optokinetic behavior)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0021599"(abducens nerve formation)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048702"(embryonic neurocranium morphogenesis)|go:"GO:0048839"(inner ear development)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050795"(regulation of behavior)|go:"GO:0050890"(cognition)|go:"GO:0050905"(neuromuscular process)|go:"GO:0060840"(artery development)|go:"GO:0060876"(semicircular canal formation)|go:"GO:0090102"(cochlea development)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|reactome:R-HSA-5617472|mint:P49639	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:TtKztiVREzd5YahM/O6ai/NLDE89606	rogid:QjQVU0uonSpj5vQU0pgzXuXmW3Y9606	rigid:ElSs1HodcUafddG6QsvKhKX+rFI	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49639	uniprotkb:Q53H96	intact:EBI-740785|uniprotkb:O43363|uniprotkb:B2R8U7|uniprotkb:A4D184	intact:EBI-2959680|ensembl:ENSP00000480945|ensembl:ENSP00000488371|uniprotkb:Q9H896|uniprotkb:Q8N3N9|uniprotkb:B3KMB5|uniprotkb:Q96HX4|uniprotkb:B4DVT6|uniprotkb:H0Y6C3	psi-mi:hxa1_human(display_long)|uniprotkb:Homeobox protein Hox-1F(gene name synonym)|uniprotkb:HOXA1(gene name)|psi-mi:HOXA1(display_short)|uniprotkb:HOX1F(gene name synonym)	psi-mi:p5cr3_human(display_long)|uniprotkb:PYCR3(gene name)|psi-mi:PYCR3(display_short)|uniprotkb:PYCRL(gene name synonym)|uniprotkb:Pyrroline-5-carboxylate reductase-like protein(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512674|imex:IM-28561-1213	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005513.1|refseq:NP_705873.2|interpro:IPR001356(Homeobox)|interpro:IPR017970|interpro:IPR020479|interpro:IPR009057(Homeodomain-like)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007634"(optokinetic behavior)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0021599"(abducens nerve formation)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048702"(embryonic neurocranium morphogenesis)|go:"GO:0048839"(inner ear development)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050795"(regulation of behavior)|go:"GO:0050890"(cognition)|go:"GO:0050905"(neuromuscular process)|go:"GO:0060840"(artery development)|go:"GO:0060876"(semicircular canal formation)|go:"GO:0090102"(cochlea development)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|reactome:R-HSA-5617472|mint:P49639	ensembl:ENST00000495276(transcript)|ensembl:ENST00000632107(transcript)|go:"GO:0004735"(pyrroline-5-carboxylate reductase activity)|go:"GO:0005829"(cytosol)|go:"GO:0045171"(intercellular bridge)|go:"GO:0055129"(L-proline biosynthetic process)|go:"GO:0072686"(mitotic spindle)|interpro:IPR000304(Delta 1-pyrroline-5-carboxylate reductase)|interpro:IPR008927(6-phosphogluconate dehydrogenase, C-terminal-like)|interpro:IPR028939|interpro:IPR029036|interpro:IPR036291|mint:Q53H96|reactome:R-HSA-8964539|ensembl:ENSG00000276657(gene)|ensembl:ENSG00000104524(gene)|refseq:NP_075566.2|refseq:NP_001316795.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:QjQVU0uonSpj5vQU0pgzXuXmW3Y9606	rogid:n2snI64kwT1vICZ4DA9tmdtS4vU9606	rigid:bXUBV5VrNCgBlUl9l9VgS4Mt/Qo	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49639	uniprotkb:Q7KZF4	intact:EBI-740785|uniprotkb:O43363|uniprotkb:B2R8U7|uniprotkb:A4D184	intact:EBI-1044112|uniprotkb:Q13122|ensembl:ENSP00000346762|uniprotkb:Q96AG0	psi-mi:hxa1_human(display_long)|uniprotkb:Homeobox protein Hox-1F(gene name synonym)|uniprotkb:HOXA1(gene name)|psi-mi:HOXA1(display_short)|uniprotkb:HOX1F(gene name synonym)	psi-mi:snd1_human(display_long)|uniprotkb:100 kDa coactivator(gene name synonym)|uniprotkb:EBNA2 coactivator p100(gene name synonym)|uniprotkb:Tudor domain-containing protein 11(gene name synonym)|uniprotkb:SND1(gene name)|psi-mi:SND1(display_short)|uniprotkb:p100 co-activator(gene name synonym)|uniprotkb:TDRD11(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512702|imex:IM-28561-781	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005513.1|refseq:NP_705873.2|interpro:IPR001356(Homeobox)|interpro:IPR017970|interpro:IPR020479|interpro:IPR009057(Homeodomain-like)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007634"(optokinetic behavior)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0021599"(abducens nerve formation)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048702"(embryonic neurocranium morphogenesis)|go:"GO:0048839"(inner ear development)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050795"(regulation of behavior)|go:"GO:0050890"(cognition)|go:"GO:0050905"(neuromuscular process)|go:"GO:0060840"(artery development)|go:"GO:0060876"(semicircular canal formation)|go:"GO:0090102"(cochlea development)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|reactome:R-HSA-5617472|mint:P49639	refseq:NP_055205.2|ensembl:ENSG00000197157(gene)|ensembl:ENST00000354725(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004518"(nuclease activity)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0010564"(regulation of cell cycle process)|go:"GO:0010587"(miRNA catabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016442"(RISC complex)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0042470"(melanosome)|go:"GO:0045296"(cadherin binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097433"(dense body)|go:"GO:1905172"(RISC complex binding)|interpro:IPR002071(Thermonuclease active site)|interpro:IPR002999(Tudor)|interpro:IPR016071("Staphylococcal nuclease (SNase-like), OB-fold")|interpro:IPR016685(RNA-induced silencing complex, nuclease component Tudor-SN)|interpro:IPR035437|mint:Q7KZF4|rcsb pdb:2E6N|rcsb pdb:2HQE|rcsb pdb:2HQX|rcsb pdb:2O4X|rcsb pdb:3BDL|rcsb pdb:3OMC|rcsb pdb:3OMG|rcsb pdb:4QMG|rcsb pdb:5M9O|reactome:R-HSA-6802952|dip:DIP-29613N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:QjQVU0uonSpj5vQU0pgzXuXmW3Y9606	rogid:I9JNlRfASs5dwk0JZQ+F+GsW94g9606	rigid:NuAfjxIiEJDtu5Fgwa71IZbbOJw	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9UIS9	uniprotkb:Q13487	intact:EBI-867196|uniprotkb:K7ELI2|uniprotkb:Q9UNZ9|uniprotkb:K7EQZ4|uniprotkb:K7ESN0|uniprotkb:A4UTZ0|uniprotkb:O15248|uniprotkb:O95241|uniprotkb:Q7Z7B5|uniprotkb:Q8N4W4|uniprotkb:Q9UNZ6|uniprotkb:Q9UNZ7|uniprotkb:Q9UNZ8|uniprotkb:B4DXJ5|uniprotkb:E9PEC5|intact:EBI-10977266|ensembl:ENSP00000269468|ensembl:ENSP00000372407|ensembl:ENSP00000467017	intact:EBI-11603264|uniprotkb:D6W663|uniprotkb:B2RBZ6|uniprotkb:Q13486|ensembl:ENSP00000221573	psi-mi:mbd1_human(display_long)|uniprotkb:CXXC3(gene name synonym)|uniprotkb:Methyl-CpG-binding protein MBD1(gene name synonym)|uniprotkb:Protein containing methyl-CpG-binding domain 1(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 3(gene name synonym)|uniprotkb:MBD1(gene name)|psi-mi:MBD1(display_short)|uniprotkb:PCM1(gene name synonym)	psi-mi:snpc2_human(display_long)|uniprotkb:SNAPC2(gene name)|psi-mi:SNAPC2(display_short)|uniprotkb:Proximal sequence element-binding transcription factor subunit delta(gene name synonym)|uniprotkb:SNAP45(gene name synonym)|uniprotkb:Small nuclear RNA-activating complex polypeptide 2(gene name synonym)|uniprotkb:snRNA-activating protein complex 45 kDa subunit(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512938|imex:IM-28561-1033	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001191065.1|refseq:NP_001191068.1|refseq:NP_001191071.1|refseq:NP_001191072.1|refseq:NP_001191080.1|refseq:NP_002375.1|refseq:NP_056669.2|refseq:NP_056670.2|refseq:NP_056671.2|refseq:NP_056723.2|refseq:XP_011524295.1|refseq:XP_016881249.1|refseq:XP_016881259.1|refseq:XP_016881260.1|refseq:XP_016881265.1|refseq:XP_011524296.1|refseq:XP_011524308.1|refseq:NP_001191066.1|refseq:NP_001191067.1|refseq:NP_001191069.1|refseq:NP_001191070.1|refseq:XP_005258328.1|ensembl:ENSG00000141644(gene)|ensembl:ENST00000269468(transcript)|ensembl:ENST00000382948(transcript)|ensembl:ENST00000591416(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0010385"(double-stranded methylated DNA binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032355"(response to estradiol)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR016177(DNA-binding, integrase-type)|mint:Q9UIS9|rcsb pdb:1D9N|rcsb pdb:1IG4|rcsb pdb:4D4W|rcsb pdb:5W9Q|rcsb pdb:6D1T|reactome:R-HSA-3899300	refseq:NP_003074.1|ensembl:ENSG00000104976(gene)|ensembl:ENST00000221573(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006383"(transcription by RNA polymerase III)|go:"GO:0009301"(snRNA transcription)|go:"GO:0016251"(RNA polymerase II general transcription initiation factor activity)|go:"GO:0016604"(nuclear body)|interpro:IPR021281|mint:Q13487|reactome:R-HSA-6807505|reactome:R-HSA-749476|reactome:R-HSA-76071|dip:DIP-505N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:I6StIYNuO8jT6ZR1YxoZnzDrP/I9606	rogid:zQsHPfvUx1nPRhTDBLXoFMxelTQ9606	rigid:i7F6Nvv0xbWEKHgFvkFbivMhg78	false	sufficient binding region:80-340	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9UIS9	uniprotkb:Q99750	intact:EBI-867196|uniprotkb:K7ELI2|uniprotkb:Q9UNZ9|uniprotkb:K7EQZ4|uniprotkb:K7ESN0|uniprotkb:A4UTZ0|uniprotkb:O15248|uniprotkb:O95241|uniprotkb:Q7Z7B5|uniprotkb:Q8N4W4|uniprotkb:Q9UNZ6|uniprotkb:Q9UNZ7|uniprotkb:Q9UNZ8|uniprotkb:B4DXJ5|uniprotkb:E9PEC5|intact:EBI-10977266|ensembl:ENSP00000269468|ensembl:ENSP00000372407|ensembl:ENSP00000467017	intact:EBI-724076|ensembl:ENSP00000230321|ensembl:ENSP00000362142	psi-mi:mbd1_human(display_long)|uniprotkb:CXXC3(gene name synonym)|uniprotkb:Methyl-CpG-binding protein MBD1(gene name synonym)|uniprotkb:Protein containing methyl-CpG-binding domain 1(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 3(gene name synonym)|uniprotkb:MBD1(gene name)|psi-mi:MBD1(display_short)|uniprotkb:PCM1(gene name synonym)	psi-mi:mdfi_human(display_long)|uniprotkb:Myogenic repressor I-mf(gene name synonym)|uniprotkb:MDFI(gene name)|psi-mi:MDFI(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512866|imex:IM-28561-1223	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001191065.1|refseq:NP_001191068.1|refseq:NP_001191071.1|refseq:NP_001191072.1|refseq:NP_001191080.1|refseq:NP_002375.1|refseq:NP_056669.2|refseq:NP_056670.2|refseq:NP_056671.2|refseq:NP_056723.2|refseq:XP_011524295.1|refseq:XP_016881249.1|refseq:XP_016881259.1|refseq:XP_016881260.1|refseq:XP_016881265.1|refseq:XP_011524296.1|refseq:XP_011524308.1|refseq:NP_001191066.1|refseq:NP_001191067.1|refseq:NP_001191069.1|refseq:NP_001191070.1|refseq:XP_005258328.1|ensembl:ENSG00000141644(gene)|ensembl:ENST00000269468(transcript)|ensembl:ENST00000382948(transcript)|ensembl:ENST00000591416(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0010385"(double-stranded methylated DNA binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032355"(response to estradiol)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR016177(DNA-binding, integrase-type)|mint:Q9UIS9|rcsb pdb:1D9N|rcsb pdb:1IG4|rcsb pdb:4D4W|rcsb pdb:5W9Q|rcsb pdb:6D1T|reactome:R-HSA-3899300	refseq:NP_005577.1|ensembl:ENSG00000112559(gene)|ensembl:ENST00000230321(transcript)|ensembl:ENST00000373051(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0060707"(trophoblast giant cell differentiation)|go:"GO:0140416"(transcription regulator inhibitor activity)|interpro:IPR026134|mint:Q99750|refseq:NP_001287733.1|refseq:NP_001287734.1|refseq:NP_001287735.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:I6StIYNuO8jT6ZR1YxoZnzDrP/I9606	rogid:V3vU0fihMOW18DMHAiDbuZ3asNU9606	rigid:PwppdPhtpE/NMAXQG0QfGzB9gaA	false	sufficient binding region:80-340	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9UIS9	uniprotkb:Q8WZA1	intact:EBI-867196|uniprotkb:K7ELI2|uniprotkb:Q9UNZ9|uniprotkb:K7EQZ4|uniprotkb:K7ESN0|uniprotkb:A4UTZ0|uniprotkb:O15248|uniprotkb:O95241|uniprotkb:Q7Z7B5|uniprotkb:Q8N4W4|uniprotkb:Q9UNZ6|uniprotkb:Q9UNZ7|uniprotkb:Q9UNZ8|uniprotkb:B4DXJ5|uniprotkb:E9PEC5|intact:EBI-10977266|ensembl:ENSP00000269468|ensembl:ENSP00000372407|ensembl:ENSP00000467017	intact:EBI-3912424|uniprotkb:Q5VST2|uniprotkb:D3DQ16|uniprotkb:Q9BV55|uniprotkb:Q9H9L8|uniprotkb:Q9NXF9|uniprotkb:Q9NYF7|ensembl:ENSP00000361052|uniprotkb:Q5VST3	psi-mi:mbd1_human(display_long)|uniprotkb:CXXC3(gene name synonym)|uniprotkb:Methyl-CpG-binding protein MBD1(gene name synonym)|uniprotkb:Protein containing methyl-CpG-binding domain 1(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 3(gene name synonym)|uniprotkb:MBD1(gene name)|psi-mi:MBD1(display_short)|uniprotkb:PCM1(gene name synonym)	psi-mi:pmgt1_human(display_long)|uniprotkb:POMGNT1(gene name)|psi-mi:POMGNT1(display_short)|uniprotkb:MGAT1.2(gene name synonym)|uniprotkb:"UDP-GlcNAc:alpha-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I.2"(gene name synonym)|uniprotkb:UNQ746/PRO1475(orf name)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512920|imex:IM-28561-785	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001191065.1|refseq:NP_001191068.1|refseq:NP_001191071.1|refseq:NP_001191072.1|refseq:NP_001191080.1|refseq:NP_002375.1|refseq:NP_056669.2|refseq:NP_056670.2|refseq:NP_056671.2|refseq:NP_056723.2|refseq:XP_011524295.1|refseq:XP_016881249.1|refseq:XP_016881259.1|refseq:XP_016881260.1|refseq:XP_016881265.1|refseq:XP_011524296.1|refseq:XP_011524308.1|refseq:NP_001191066.1|refseq:NP_001191067.1|refseq:NP_001191069.1|refseq:NP_001191070.1|refseq:XP_005258328.1|ensembl:ENSG00000141644(gene)|ensembl:ENST00000269468(transcript)|ensembl:ENST00000382948(transcript)|ensembl:ENST00000591416(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0010385"(double-stranded methylated DNA binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032355"(response to estradiol)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR016177(DNA-binding, integrase-type)|mint:Q9UIS9|rcsb pdb:1D9N|rcsb pdb:1IG4|rcsb pdb:4D4W|rcsb pdb:5W9Q|rcsb pdb:6D1T|reactome:R-HSA-3899300	refseq:XP_006710819.1|refseq:NP_060209.3|ensembl:ENSG00000085998(gene)|ensembl:ENST00000371984(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0006493"(protein O-linked glycosylation)|go:"GO:0008375"(acetylglucosaminyltransferase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016266"(O-glycan processing)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030173"(integral component of Golgi membrane)|go:"GO:0047223"(beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity)|interpro:IPR004139(Glycosyl transferase, family 13)|interpro:IPR029044|interpro:IPR039474|interpro:IPR039477|mint:Q8WZA1|rcsb pdb:5GGF|rcsb pdb:5GGG|rcsb pdb:5GGI|rcsb pdb:5GGJ|rcsb pdb:5GGK|rcsb pdb:5GGL|rcsb pdb:5GGN|rcsb pdb:5GGO|rcsb pdb:5GGP|rcsb pdb:5XFC|reactome:R-HSA-5083628|reactome:R-HSA-5173105|refseq:XP_016857179.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:I6StIYNuO8jT6ZR1YxoZnzDrP/I9606	rogid:Ohk+ND7B4l9EvsCnHL5w7NQHeIk9606	rigid:pQ4XgoTHToUZTefaMj6KlKFm1gI	false	sufficient binding region:80-340	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9UIS9	uniprotkb:Q8N2S1	intact:EBI-867196|uniprotkb:K7ELI2|uniprotkb:Q9UNZ9|uniprotkb:K7EQZ4|uniprotkb:K7ESN0|uniprotkb:A4UTZ0|uniprotkb:O15248|uniprotkb:O95241|uniprotkb:Q7Z7B5|uniprotkb:Q8N4W4|uniprotkb:Q9UNZ6|uniprotkb:Q9UNZ7|uniprotkb:Q9UNZ8|uniprotkb:B4DXJ5|uniprotkb:E9PEC5|intact:EBI-10977266|ensembl:ENSP00000269468|ensembl:ENSP00000372407|ensembl:ENSP00000467017	intact:EBI-947718|uniprotkb:O75412|uniprotkb:O75413|uniprotkb:O00508|ensembl:ENSP00000311905	psi-mi:mbd1_human(display_long)|uniprotkb:CXXC3(gene name synonym)|uniprotkb:Methyl-CpG-binding protein MBD1(gene name synonym)|uniprotkb:Protein containing methyl-CpG-binding domain 1(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 3(gene name synonym)|uniprotkb:MBD1(gene name)|psi-mi:MBD1(display_short)|uniprotkb:PCM1(gene name synonym)	psi-mi:ltbp4_human(display_long)|uniprotkb:LTBP4(gene name)|psi-mi:LTBP4(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512857|imex:IM-28561-139	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001191065.1|refseq:NP_001191068.1|refseq:NP_001191071.1|refseq:NP_001191072.1|refseq:NP_001191080.1|refseq:NP_002375.1|refseq:NP_056669.2|refseq:NP_056670.2|refseq:NP_056671.2|refseq:NP_056723.2|refseq:XP_011524295.1|refseq:XP_016881249.1|refseq:XP_016881259.1|refseq:XP_016881260.1|refseq:XP_016881265.1|refseq:XP_011524296.1|refseq:XP_011524308.1|refseq:NP_001191066.1|refseq:NP_001191067.1|refseq:NP_001191069.1|refseq:NP_001191070.1|refseq:XP_005258328.1|ensembl:ENSG00000141644(gene)|ensembl:ENST00000269468(transcript)|ensembl:ENST00000382948(transcript)|ensembl:ENST00000591416(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0010385"(double-stranded methylated DNA binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032355"(response to estradiol)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR016177(DNA-binding, integrase-type)|mint:Q9UIS9|rcsb pdb:1D9N|rcsb pdb:1IG4|rcsb pdb:4D4W|rcsb pdb:5W9Q|rcsb pdb:6D1T|reactome:R-HSA-3899300	refseq:NP_001036009.1|refseq:NP_001036010.1|refseq:NP_003564.2|ensembl:ENSG00000090006(gene)|ensembl:ENST00000308370(transcript)|go:"GO:0001527"(microfibril)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006457"(protein folding)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007275"(multicellular organism development)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0030252"(growth hormone secretion)|go:"GO:0031012"(extracellular matrix)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0048251"(elastic fiber assembly)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR017878|interpro:IPR018097|interpro:IPR036773|mint:Q8N2S1|reactome:R-HSA-2129379	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:I6StIYNuO8jT6ZR1YxoZnzDrP/I9606	rogid:mBWo9asZp3rjkytgvTD+7OE5K5I9606	rigid:MeDNNjMvvqtgzaF8qIjVoQbR2cw	false	sufficient binding region:80-340	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9UIS9	uniprotkb:Q9NS15	intact:EBI-867196|uniprotkb:K7ELI2|uniprotkb:Q9UNZ9|uniprotkb:K7EQZ4|uniprotkb:K7ESN0|uniprotkb:A4UTZ0|uniprotkb:O15248|uniprotkb:O95241|uniprotkb:Q7Z7B5|uniprotkb:Q8N4W4|uniprotkb:Q9UNZ6|uniprotkb:Q9UNZ7|uniprotkb:Q9UNZ8|uniprotkb:B4DXJ5|uniprotkb:E9PEC5|intact:EBI-10977266|ensembl:ENSP00000269468|ensembl:ENSP00000372407|ensembl:ENSP00000467017	intact:EBI-3927098|uniprotkb:Q9H7K2|uniprotkb:Q96HB9|uniprotkb:Q9UFN4|uniprotkb:O15107|ensembl:ENSP00000301873	psi-mi:mbd1_human(display_long)|uniprotkb:CXXC3(gene name synonym)|uniprotkb:Methyl-CpG-binding protein MBD1(gene name synonym)|uniprotkb:Protein containing methyl-CpG-binding domain 1(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 3(gene name synonym)|uniprotkb:MBD1(gene name)|psi-mi:MBD1(display_short)|uniprotkb:PCM1(gene name synonym)	psi-mi:ltbp3_human(display_long)|uniprotkb:LTBP3(gene name)|psi-mi:LTBP3(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512848|imex:IM-28561-1705	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001191065.1|refseq:NP_001191068.1|refseq:NP_001191071.1|refseq:NP_001191072.1|refseq:NP_001191080.1|refseq:NP_002375.1|refseq:NP_056669.2|refseq:NP_056670.2|refseq:NP_056671.2|refseq:NP_056723.2|refseq:XP_011524295.1|refseq:XP_016881249.1|refseq:XP_016881259.1|refseq:XP_016881260.1|refseq:XP_016881265.1|refseq:XP_011524296.1|refseq:XP_011524308.1|refseq:NP_001191066.1|refseq:NP_001191067.1|refseq:NP_001191069.1|refseq:NP_001191070.1|refseq:XP_005258328.1|ensembl:ENSG00000141644(gene)|ensembl:ENST00000269468(transcript)|ensembl:ENST00000382948(transcript)|ensembl:ENST00000591416(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0010385"(double-stranded methylated DNA binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032355"(response to estradiol)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR016177(DNA-binding, integrase-type)|mint:Q9UIS9|rcsb pdb:1D9N|rcsb pdb:1IG4|rcsb pdb:4D4W|rcsb pdb:5W9Q|rcsb pdb:6D1T|reactome:R-HSA-3899300	refseq:NP_001123616.1|refseq:NP_001157738.1|refseq:NP_066548.2|go:"GO:0036363"(transforming growth factor beta activation)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0046849"(bone remodeling)|go:"GO:0048251"(elastic fiber assembly)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0060430"(lung saccule development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:1902462"(positive regulation of mesenchymal stem cell proliferation)|go:"GO:2000741"(positive regulation of mesenchymal stem cell differentiation)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR017878|interpro:IPR018097|interpro:IPR026823|interpro:IPR036773|mint:Q9NS15|reactome:R-HSA-2129379|ensembl:ENSG00000168056(gene)|ensembl:ENST00000301873(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:I6StIYNuO8jT6ZR1YxoZnzDrP/I9606	rogid:wTlw1eFDbHiWYm9/2sgGxqK1uI49606	rigid:K1jBbN7iH81FkfkpqaambYz935A	false	sufficient binding region:80-340	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9UIS9	uniprotkb:A4QMR6	intact:EBI-867196|uniprotkb:K7ELI2|uniprotkb:Q9UNZ9|uniprotkb:K7EQZ4|uniprotkb:K7ESN0|uniprotkb:A4UTZ0|uniprotkb:O15248|uniprotkb:O95241|uniprotkb:Q7Z7B5|uniprotkb:Q8N4W4|uniprotkb:Q9UNZ6|uniprotkb:Q9UNZ7|uniprotkb:Q9UNZ8|uniprotkb:B4DXJ5|uniprotkb:E9PEC5|intact:EBI-10977266|ensembl:ENSP00000269468|ensembl:ENSP00000372407|ensembl:ENSP00000467017	intact:EBI-26512834	psi-mi:mbd1_human(display_long)|uniprotkb:CXXC3(gene name synonym)|uniprotkb:Methyl-CpG-binding protein MBD1(gene name synonym)|uniprotkb:Protein containing methyl-CpG-binding domain 1(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 3(gene name synonym)|uniprotkb:MBD1(gene name)|psi-mi:MBD1(display_short)|uniprotkb:PCM1(gene name synonym)	psi-mi:a4qmr6_human(display_long)|uniprotkb:LOC161527(gene name)|psi-mi:LOC161527(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512839|imex:IM-28561-1029	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001191065.1|refseq:NP_001191068.1|refseq:NP_001191071.1|refseq:NP_001191072.1|refseq:NP_001191080.1|refseq:NP_002375.1|refseq:NP_056669.2|refseq:NP_056670.2|refseq:NP_056671.2|refseq:NP_056723.2|refseq:XP_011524295.1|refseq:XP_016881249.1|refseq:XP_016881259.1|refseq:XP_016881260.1|refseq:XP_016881265.1|refseq:XP_011524296.1|refseq:XP_011524308.1|refseq:NP_001191066.1|refseq:NP_001191067.1|refseq:NP_001191069.1|refseq:NP_001191070.1|refseq:XP_005258328.1|ensembl:ENSG00000141644(gene)|ensembl:ENST00000269468(transcript)|ensembl:ENST00000382948(transcript)|ensembl:ENST00000591416(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0010385"(double-stranded methylated DNA binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032355"(response to estradiol)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR016177(DNA-binding, integrase-type)|mint:Q9UIS9|rcsb pdb:1D9N|rcsb pdb:1IG4|rcsb pdb:4D4W|rcsb pdb:5W9Q|rcsb pdb:6D1T|reactome:R-HSA-3899300	mint:A4QMR6|interpro:IPR026737	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:I6StIYNuO8jT6ZR1YxoZnzDrP/I9606	rogid:KvNuZ8rcDl4zQK2F9RHcXD4oHGQ9606	rigid:plzAkSF206x9ptddY1cLUKXLLq0	false	sufficient binding region:80-340	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9UIS9	uniprotkb:P0C7I6	intact:EBI-867196|uniprotkb:K7ELI2|uniprotkb:Q9UNZ9|uniprotkb:K7EQZ4|uniprotkb:K7ESN0|uniprotkb:A4UTZ0|uniprotkb:O15248|uniprotkb:O95241|uniprotkb:Q7Z7B5|uniprotkb:Q8N4W4|uniprotkb:Q9UNZ6|uniprotkb:Q9UNZ7|uniprotkb:Q9UNZ8|uniprotkb:B4DXJ5|uniprotkb:E9PEC5|intact:EBI-10977266|ensembl:ENSP00000269468|ensembl:ENSP00000372407|ensembl:ENSP00000467017	intact:EBI-26512809|ensembl:ENSP00000402239|ensembl:ENSP00000468232|uniprotkb:B4DEG3|uniprotkb:B4DWR8|uniprotkb:B4E133|uniprotkb:B7ZAM4	psi-mi:mbd1_human(display_long)|uniprotkb:CXXC3(gene name synonym)|uniprotkb:Methyl-CpG-binding protein MBD1(gene name synonym)|uniprotkb:Protein containing methyl-CpG-binding domain 1(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 3(gene name synonym)|uniprotkb:MBD1(gene name)|psi-mi:MBD1(display_short)|uniprotkb:PCM1(gene name synonym)	psi-mi:cc159_human(display_long)|uniprotkb:CCDC159(gene name)|psi-mi:CCDC159(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512825|imex:IM-28561-1027	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001191065.1|refseq:NP_001191068.1|refseq:NP_001191071.1|refseq:NP_001191072.1|refseq:NP_001191080.1|refseq:NP_002375.1|refseq:NP_056669.2|refseq:NP_056670.2|refseq:NP_056671.2|refseq:NP_056723.2|refseq:XP_011524295.1|refseq:XP_016881249.1|refseq:XP_016881259.1|refseq:XP_016881260.1|refseq:XP_016881265.1|refseq:XP_011524296.1|refseq:XP_011524308.1|refseq:NP_001191066.1|refseq:NP_001191067.1|refseq:NP_001191069.1|refseq:NP_001191070.1|refseq:XP_005258328.1|ensembl:ENSG00000141644(gene)|ensembl:ENST00000269468(transcript)|ensembl:ENST00000382948(transcript)|ensembl:ENST00000591416(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0010385"(double-stranded methylated DNA binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032355"(response to estradiol)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR016177(DNA-binding, integrase-type)|mint:Q9UIS9|rcsb pdb:1D9N|rcsb pdb:1IG4|rcsb pdb:4D4W|rcsb pdb:5W9Q|rcsb pdb:6D1T|reactome:R-HSA-3899300	ensembl:ENSG00000183401(gene)|ensembl:ENST00000588790(transcript)|interpro:IPR039284|mint:P0C7I6|ensembl:ENST00000458408(transcript)|refseq:NP_001073972.2|refseq:XP_016881749.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:I6StIYNuO8jT6ZR1YxoZnzDrP/I9606	rogid:ZA6xO5sAXuKbrKUiVlZ5kBeSNAc9606	rigid:1mugcljlZsoMmi9OvBFCLIZ3AiA	false	sufficient binding region:80-340	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9UIS9	uniprotkb:P28799	intact:EBI-867196|uniprotkb:K7ELI2|uniprotkb:Q9UNZ9|uniprotkb:K7EQZ4|uniprotkb:K7ESN0|uniprotkb:A4UTZ0|uniprotkb:O15248|uniprotkb:O95241|uniprotkb:Q7Z7B5|uniprotkb:Q8N4W4|uniprotkb:Q9UNZ6|uniprotkb:Q9UNZ7|uniprotkb:Q9UNZ8|uniprotkb:B4DXJ5|uniprotkb:E9PEC5|intact:EBI-10977266|ensembl:ENSP00000269468|ensembl:ENSP00000372407|ensembl:ENSP00000467017	intact:EBI-747754|uniprotkb:P23781|uniprotkb:P23782|uniprotkb:P23783|uniprotkb:P23784|uniprotkb:Q9BWE7|uniprotkb:Q9UCH0|ensembl:ENSP00000053867|uniprotkb:Q53Y88|uniprotkb:Q540U8|uniprotkb:D3DX55|uniprotkb:Q53HQ8|uniprotkb:Q9H8S1	psi-mi:mbd1_human(display_long)|uniprotkb:CXXC3(gene name synonym)|uniprotkb:Methyl-CpG-binding protein MBD1(gene name synonym)|uniprotkb:Protein containing methyl-CpG-binding domain 1(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 3(gene name synonym)|uniprotkb:MBD1(gene name)|psi-mi:MBD1(display_short)|uniprotkb:PCM1(gene name synonym)	psi-mi:grn_human(display_long)|uniprotkb:Proepithelin(gene name synonym)|uniprotkb:GRN(gene name)|psi-mi:GRN(display_short)|uniprotkb:Acrogranin(gene name synonym)|uniprotkb:Epithelin precursor(gene name synonym)|uniprotkb:Glycoprotein of 88 Kda(gene name synonym)|uniprotkb:Granulin precursor(gene name synonym)|uniprotkb:PC cell-derived growth factor(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512791|imex:IM-28561-1025	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001191065.1|refseq:NP_001191068.1|refseq:NP_001191071.1|refseq:NP_001191072.1|refseq:NP_001191080.1|refseq:NP_002375.1|refseq:NP_056669.2|refseq:NP_056670.2|refseq:NP_056671.2|refseq:NP_056723.2|refseq:XP_011524295.1|refseq:XP_016881249.1|refseq:XP_016881259.1|refseq:XP_016881260.1|refseq:XP_016881265.1|refseq:XP_011524296.1|refseq:XP_011524308.1|refseq:NP_001191066.1|refseq:NP_001191067.1|refseq:NP_001191069.1|refseq:NP_001191070.1|refseq:XP_005258328.1|ensembl:ENSG00000141644(gene)|ensembl:ENST00000269468(transcript)|ensembl:ENST00000382948(transcript)|ensembl:ENST00000591416(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0010385"(double-stranded methylated DNA binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032355"(response to estradiol)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR016177(DNA-binding, integrase-type)|mint:Q9UIS9|rcsb pdb:1D9N|rcsb pdb:1IG4|rcsb pdb:4D4W|rcsb pdb:5W9Q|rcsb pdb:6D1T|reactome:R-HSA-3899300	refseq:NP_002078.1|ensembl:ENSG00000030582(gene)|ensembl:ENST00000053867(transcript)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0003723"(RNA binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007040"(lysosome organization)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048680"(positive regulation of axon regeneration)|refseq:XP_005257310.1|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0060266"(negative regulation of respiratory burst involved in inflammatory response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0106016"(positive regulation of inflammatory response to wounding)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1902564"(negative regulation of neutrophil activation)|go:"GO:1903334"(positive regulation of protein folding)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1905247"(positive regulation of aspartic-type peptidase activity)|go:"GO:1905673"(positive regulation of lysosome organization)|interpro:IPR000118(Granulin)|interpro:IPR037277|interpro:IPR039036|mint:P28799|rcsb pdb:1G26|rcsb pdb:2JYE|rcsb pdb:2JYT|rcsb pdb:2JYU|rcsb pdb:2JYV|rcsb pdb:6NUG|reactome:R-HSA-6798695|dip:DIP-41742N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:I6StIYNuO8jT6ZR1YxoZnzDrP/I9606	rogid:SaujQCj7wHfPYunGzgTgG+jQgA89606	rigid:WGbEQA+NsAbCaVuKGq4/Hmf/gO4	false	sufficient binding region:80-340	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9UIS9	uniprotkb:Q9Y219	intact:EBI-867196|uniprotkb:K7ELI2|uniprotkb:Q9UNZ9|uniprotkb:K7EQZ4|uniprotkb:K7ESN0|uniprotkb:A4UTZ0|uniprotkb:O15248|uniprotkb:O95241|uniprotkb:Q7Z7B5|uniprotkb:Q8N4W4|uniprotkb:Q9UNZ6|uniprotkb:Q9UNZ7|uniprotkb:Q9UNZ8|uniprotkb:B4DXJ5|uniprotkb:E9PEC5|intact:EBI-10977266|ensembl:ENSP00000269468|ensembl:ENSP00000372407|ensembl:ENSP00000467017	intact:EBI-946223|uniprotkb:Q9UE17|uniprotkb:Q9UE99|uniprotkb:Q9UNK8|uniprotkb:Q9Y6P9|uniprotkb:Q9Y6Q0|ensembl:ENSP00000328169	psi-mi:mbd1_human(display_long)|uniprotkb:CXXC3(gene name synonym)|uniprotkb:Methyl-CpG-binding protein MBD1(gene name synonym)|uniprotkb:Protein containing methyl-CpG-binding domain 1(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 3(gene name synonym)|uniprotkb:MBD1(gene name)|psi-mi:MBD1(display_short)|uniprotkb:PCM1(gene name synonym)	psi-mi:jag2_human(display_long)|uniprotkb:JAG2(gene name)|psi-mi:JAG2(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512800|imex:IM-28561-137	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001191065.1|refseq:NP_001191068.1|refseq:NP_001191071.1|refseq:NP_001191072.1|refseq:NP_001191080.1|refseq:NP_002375.1|refseq:NP_056669.2|refseq:NP_056670.2|refseq:NP_056671.2|refseq:NP_056723.2|refseq:XP_011524295.1|refseq:XP_016881249.1|refseq:XP_016881259.1|refseq:XP_016881260.1|refseq:XP_016881265.1|refseq:XP_011524296.1|refseq:XP_011524308.1|refseq:NP_001191066.1|refseq:NP_001191067.1|refseq:NP_001191069.1|refseq:NP_001191070.1|refseq:XP_005258328.1|ensembl:ENSG00000141644(gene)|ensembl:ENST00000269468(transcript)|ensembl:ENST00000382948(transcript)|ensembl:ENST00000591416(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0010385"(double-stranded methylated DNA binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032355"(response to estradiol)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR016177(DNA-binding, integrase-type)|mint:Q9UIS9|rcsb pdb:1D9N|rcsb pdb:1IG4|rcsb pdb:4D4W|rcsb pdb:5W9Q|rcsb pdb:6D1T|reactome:R-HSA-3899300	refseq:NP_002217.3|refseq:NP_660142.1|ensembl:ENSG00000184916(gene)|ensembl:ENST00000331782(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003016"(respiratory system process)|go:"GO:0005112"(Notch binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008083"(growth factor activity)|go:"GO:0009912"(auditory receptor cell fate commitment)|go:"GO:0016331"(morphogenesis of embryonic epithelium)|go:"GO:0030154"(cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030217"(T cell differentiation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042492"(gamma-delta T cell differentiation)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:1990134"(epithelial cell apoptotic process involved in palatal shelf morphogenesis)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR001774("Delta/Serrate/lag-2 (DSL) protein")|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011651(Notch ligand, N-terminal)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR018097|interpro:IPR026219|mint:Q9Y219|rcsb pdb:5MW5|rcsb pdb:5MW7|rcsb pdb:5MWF|reactome:R-HSA-2122948|reactome:R-HSA-2644606|reactome:R-HSA-2660826|reactome:R-HSA-2691232|go:"GO:0005887"(integral component of plasma membrane)|reactome:R-HSA-2894862|reactome:R-HSA-2979096|reactome:R-HSA-9013507	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:I6StIYNuO8jT6ZR1YxoZnzDrP/I9606	rogid:GoH5Lw1zl+3dhA4RSpJTyQ0LY4Q9606	rigid:9mR2FHViy4Swid98Kf1egF+sbvU	false	sufficient binding region:80-340	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9UIS9	uniprotkb:P26641	intact:EBI-867196|uniprotkb:K7ELI2|uniprotkb:Q9UNZ9|uniprotkb:K7EQZ4|uniprotkb:K7ESN0|uniprotkb:A4UTZ0|uniprotkb:O15248|uniprotkb:O95241|uniprotkb:Q7Z7B5|uniprotkb:Q8N4W4|uniprotkb:Q9UNZ6|uniprotkb:Q9UNZ7|uniprotkb:Q9UNZ8|uniprotkb:B4DXJ5|uniprotkb:E9PEC5|intact:EBI-10977266|ensembl:ENSP00000269468|ensembl:ENSP00000372407|ensembl:ENSP00000467017	intact:EBI-351467|uniprotkb:Q6PJ62|uniprotkb:Q6PK31|uniprotkb:Q96CU2|uniprotkb:Q9P196|intact:EBI-2321928|uniprotkb:B4DTG2|ensembl:ENSP00000331901	psi-mi:mbd1_human(display_long)|uniprotkb:CXXC3(gene name synonym)|uniprotkb:Methyl-CpG-binding protein MBD1(gene name synonym)|uniprotkb:Protein containing methyl-CpG-binding domain 1(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 3(gene name synonym)|uniprotkb:MBD1(gene name)|psi-mi:MBD1(display_short)|uniprotkb:PCM1(gene name synonym)	psi-mi:ef1g_human(display_long)|uniprotkb:PRO1608(orf name)|uniprotkb:EEF1G(gene name)|psi-mi:EEF1G(display_short)|uniprotkb:EF1G(gene name synonym)|uniprotkb:eEF-1B gamma(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512782|imex:IM-28561-1503	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001191065.1|refseq:NP_001191068.1|refseq:NP_001191071.1|refseq:NP_001191072.1|refseq:NP_001191080.1|refseq:NP_002375.1|refseq:NP_056669.2|refseq:NP_056670.2|refseq:NP_056671.2|refseq:NP_056723.2|refseq:XP_011524295.1|refseq:XP_016881249.1|refseq:XP_016881259.1|refseq:XP_016881260.1|refseq:XP_016881265.1|refseq:XP_011524296.1|refseq:XP_011524308.1|refseq:NP_001191066.1|refseq:NP_001191067.1|refseq:NP_001191069.1|refseq:NP_001191070.1|refseq:XP_005258328.1|ensembl:ENSG00000141644(gene)|ensembl:ENST00000269468(transcript)|ensembl:ENST00000382948(transcript)|ensembl:ENST00000591416(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0010385"(double-stranded methylated DNA binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032355"(response to estradiol)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR016177(DNA-binding, integrase-type)|mint:Q9UIS9|rcsb pdb:1D9N|rcsb pdb:1IG4|rcsb pdb:4D4W|rcsb pdb:5W9Q|rcsb pdb:6D1T|reactome:R-HSA-3899300	refseq:NP_001395.1|ensembl:ENSG00000254772(gene)|ensembl:ENST00000329251(transcript)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006414"(translational elongation)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0009615"(response to virus)|go:"GO:0016020"(membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001662(Translation elongation factor EF1B, gamma chain, conserved)|interpro:IPR004045(Glutathione S-transferase, N-terminal)|interpro:IPR004046(Glutathione S-transferase, C-terminal)|interpro:IPR010987(Glutathione S-transferase, C-terminal-like)|interpro:IPR036249|interpro:IPR036282|interpro:IPR036433|interpro:IPR040079|mint:P26641|rcsb pdb:1PBU|rcsb pdb:5DQS|rcsb pdb:5JPO|reactome:R-HSA-156842|dip:DIP-32516N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:I6StIYNuO8jT6ZR1YxoZnzDrP/I9606	rogid:biVN96umeEdPm/wvPN4VwbSRHTs9606	rigid:tbw9yg1RYeV7MCCanDFVwK/yW+I	false	sufficient binding region:80-340	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9UIS9	uniprotkb:Q92997	intact:EBI-867196|uniprotkb:K7ELI2|uniprotkb:Q9UNZ9|uniprotkb:K7EQZ4|uniprotkb:K7ESN0|uniprotkb:A4UTZ0|uniprotkb:O15248|uniprotkb:O95241|uniprotkb:Q7Z7B5|uniprotkb:Q8N4W4|uniprotkb:Q9UNZ6|uniprotkb:Q9UNZ7|uniprotkb:Q9UNZ8|uniprotkb:B4DXJ5|uniprotkb:E9PEC5|intact:EBI-10977266|ensembl:ENSP00000269468|ensembl:ENSP00000372407|ensembl:ENSP00000467017	intact:EBI-739789|uniprotkb:O14642|uniprotkb:Q13531|uniprotkb:Q8N5E9|uniprotkb:Q92607|uniprotkb:D3DNT0|intact:EBI-11081380|uniprotkb:B4E3E5|ensembl:ENSP00000316054	psi-mi:mbd1_human(display_long)|uniprotkb:CXXC3(gene name synonym)|uniprotkb:Methyl-CpG-binding protein MBD1(gene name synonym)|uniprotkb:Protein containing methyl-CpG-binding domain 1(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 3(gene name synonym)|uniprotkb:MBD1(gene name)|psi-mi:MBD1(display_short)|uniprotkb:PCM1(gene name synonym)	psi-mi:dvl3_human(display_long)|uniprotkb:DVL3(gene name)|psi-mi:DVL3(display_short)|uniprotkb:KIAA0208(gene name synonym)|uniprotkb:DSH homolog 3(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512773|imex:IM-28561-1219	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001191065.1|refseq:NP_001191068.1|refseq:NP_001191071.1|refseq:NP_001191072.1|refseq:NP_001191080.1|refseq:NP_002375.1|refseq:NP_056669.2|refseq:NP_056670.2|refseq:NP_056671.2|refseq:NP_056723.2|refseq:XP_011524295.1|refseq:XP_016881249.1|refseq:XP_016881259.1|refseq:XP_016881260.1|refseq:XP_016881265.1|refseq:XP_011524296.1|refseq:XP_011524308.1|refseq:NP_001191066.1|refseq:NP_001191067.1|refseq:NP_001191069.1|refseq:NP_001191070.1|refseq:XP_005258328.1|ensembl:ENSG00000141644(gene)|ensembl:ENST00000269468(transcript)|ensembl:ENST00000382948(transcript)|ensembl:ENST00000591416(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0010385"(double-stranded methylated DNA binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032355"(response to estradiol)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR016177(DNA-binding, integrase-type)|mint:Q9UIS9|rcsb pdb:1D9N|rcsb pdb:1IG4|rcsb pdb:4D4W|rcsb pdb:5W9Q|rcsb pdb:6D1T|reactome:R-HSA-3899300	refseq:NP_004414.3|dip:DIP-34509N|ensembl:ENSG00000161202(gene)|ensembl:ENST00000313143(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005829"(cytosol)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0038031"(non-canonical Wnt signaling pathway via JNK cascade)|go:"GO:0042493"|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050821"(protein stabilization)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1903827"|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001158(DIX)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003351(Dishevelled protein)|interpro:IPR008339(Dishevelled region)|interpro:IPR008342(Dishevelled-3 protein, C-terminal)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR024580|interpro:IPR029071|interpro:IPR036034|interpro:IPR036388|interpro:IPR036390|interpro:IPR038207|mint:Q92997|rcsb pdb:6V7O|rcsb pdb:6ZC6|rcsb pdb:6ZC8|reactome:R-HSA-201681|reactome:R-HSA-201688|reactome:R-HSA-4086400|reactome:R-HSA-4641258|reactome:R-HSA-4641262|reactome:R-HSA-5368598|reactome:R-HSA-5663220|reactome:R-HSA-9673324	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:I6StIYNuO8jT6ZR1YxoZnzDrP/I9606	rogid:yJ3YIp5IhvKTQwa3bK5yTjNyqXk9606	rigid:q1BU9Ywnip1Kryvj14CT28/yueU	false	sufficient binding region:80-340	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9UIS9	uniprotkb:O14579	intact:EBI-867196|uniprotkb:K7ELI2|uniprotkb:Q9UNZ9|uniprotkb:K7EQZ4|uniprotkb:K7ESN0|uniprotkb:A4UTZ0|uniprotkb:O15248|uniprotkb:O95241|uniprotkb:Q7Z7B5|uniprotkb:Q8N4W4|uniprotkb:Q9UNZ6|uniprotkb:Q9UNZ7|uniprotkb:Q9UNZ8|uniprotkb:B4DXJ5|uniprotkb:E9PEC5|intact:EBI-10977266|ensembl:ENSP00000269468|ensembl:ENSP00000372407|ensembl:ENSP00000467017	intact:EBI-711301|uniprotkb:O76097|ensembl:ENSP00000262812|uniprotkb:Q9UGP6|uniprotkb:Q6IBB8|uniprotkb:A6NKA3|uniprotkb:A6NE29	psi-mi:mbd1_human(display_long)|uniprotkb:CXXC3(gene name synonym)|uniprotkb:Methyl-CpG-binding protein MBD1(gene name synonym)|uniprotkb:Protein containing methyl-CpG-binding domain 1(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 3(gene name synonym)|uniprotkb:MBD1(gene name)|psi-mi:MBD1(display_short)|uniprotkb:PCM1(gene name synonym)	psi-mi:cope_human(display_long)|uniprotkb:COPE(gene name)|psi-mi:COPE(display_short)|uniprotkb:Epsilon-coat protein(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512764|imex:IM-28561-1699	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001191065.1|refseq:NP_001191068.1|refseq:NP_001191071.1|refseq:NP_001191072.1|refseq:NP_001191080.1|refseq:NP_002375.1|refseq:NP_056669.2|refseq:NP_056670.2|refseq:NP_056671.2|refseq:NP_056723.2|refseq:XP_011524295.1|refseq:XP_016881249.1|refseq:XP_016881259.1|refseq:XP_016881260.1|refseq:XP_016881265.1|refseq:XP_011524296.1|refseq:XP_011524308.1|refseq:NP_001191066.1|refseq:NP_001191067.1|refseq:NP_001191069.1|refseq:NP_001191070.1|refseq:XP_005258328.1|ensembl:ENSG00000141644(gene)|ensembl:ENST00000269468(transcript)|ensembl:ENST00000382948(transcript)|ensembl:ENST00000591416(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0010385"(double-stranded methylated DNA binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032355"(response to estradiol)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR016177(DNA-binding, integrase-type)|mint:Q9UIS9|rcsb pdb:1D9N|rcsb pdb:1IG4|rcsb pdb:4D4W|rcsb pdb:5W9Q|rcsb pdb:6D1T|reactome:R-HSA-3899300	refseq:NP_009194.2|ensembl:ENSG00000105669(gene)|ensembl:ENST00000262812(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0015031"(protein transport)|go:"GO:0030126"(COPI vesicle coat)|go:"GO:0030133"(transport vesicle)|go:"GO:0099612"(protein localization to axon)|interpro:IPR006822(Coatomer, epsilon subunit)|interpro:IPR011990(Tetratricopeptide-like helical)|mint:O14579|rcsb pdb:6TZT|rcsb pdb:6U3V|reactome:R-HSA-6807878|reactome:R-HSA-6811434|refseq:NP_955474.1|refseq:NP_955476.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:I6StIYNuO8jT6ZR1YxoZnzDrP/I9606	rogid:gjrR0x7iNHl/nEDtoZTjThB1dgs9606	rigid:vFnJTrTgD8NsqRHwdXxF1XnFU+c	false	sufficient binding region:80-340	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9UIS9	uniprotkb:Q96JN2	intact:EBI-867196|uniprotkb:K7ELI2|uniprotkb:Q9UNZ9|uniprotkb:K7EQZ4|uniprotkb:K7ESN0|uniprotkb:A4UTZ0|uniprotkb:O15248|uniprotkb:O95241|uniprotkb:Q7Z7B5|uniprotkb:Q8N4W4|uniprotkb:Q9UNZ6|uniprotkb:Q9UNZ7|uniprotkb:Q9UNZ8|uniprotkb:B4DXJ5|uniprotkb:E9PEC5|intact:EBI-10977266|ensembl:ENSP00000269468|ensembl:ENSP00000372407|ensembl:ENSP00000467017	intact:EBI-947045|uniprotkb:A4D1K1|uniprotkb:Q6ZVK7|uniprotkb:Q9H8M3|uniprotkb:Q9UFE1|uniprotkb:A7MCY7|uniprotkb:A8MYA7|ensembl:ENSP00000297788	psi-mi:mbd1_human(display_long)|uniprotkb:CXXC3(gene name synonym)|uniprotkb:Methyl-CpG-binding protein MBD1(gene name synonym)|uniprotkb:Protein containing methyl-CpG-binding domain 1(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 3(gene name synonym)|uniprotkb:MBD1(gene name)|psi-mi:MBD1(display_short)|uniprotkb:PCM1(gene name synonym)	psi-mi:cc136_human(display_long)|uniprotkb:NAG6(orf name)|uniprotkb:CCDC136(gene name)|psi-mi:CCDC136(display_short)|uniprotkb:KIAA1793(gene name synonym)|uniprotkb:Nasopharyngeal carcinoma-associated gene 6 protein(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512755|imex:IM-28561-351	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001191065.1|refseq:NP_001191068.1|refseq:NP_001191071.1|refseq:NP_001191072.1|refseq:NP_001191080.1|refseq:NP_002375.1|refseq:NP_056669.2|refseq:NP_056670.2|refseq:NP_056671.2|refseq:NP_056723.2|refseq:XP_011524295.1|refseq:XP_016881249.1|refseq:XP_016881259.1|refseq:XP_016881260.1|refseq:XP_016881265.1|refseq:XP_011524296.1|refseq:XP_011524308.1|refseq:NP_001191066.1|refseq:NP_001191067.1|refseq:NP_001191069.1|refseq:NP_001191070.1|refseq:XP_005258328.1|ensembl:ENSG00000141644(gene)|ensembl:ENST00000269468(transcript)|ensembl:ENST00000382948(transcript)|ensembl:ENST00000591416(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0010385"(double-stranded methylated DNA binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032355"(response to estradiol)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR016177(DNA-binding, integrase-type)|mint:Q9UIS9|rcsb pdb:1D9N|rcsb pdb:1IG4|rcsb pdb:4D4W|rcsb pdb:5W9Q|rcsb pdb:6D1T|reactome:R-HSA-3899300	refseq:NP_001188301.1|refseq:NP_073579.4|refseq:XP_016868022.1|ensembl:ENSG00000128596(gene)|ensembl:ENST00000297788(transcript)|go:"GO:0001675"(acrosome assembly)|go:"GO:0002080"(acrosomal membrane)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0016021"(integral component of membrane)|mint:Q96JN2	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:I6StIYNuO8jT6ZR1YxoZnzDrP/I9606	rogid:TEC/bwvyX2dh9hhk8JmyVUWhSKo9606	rigid:X8aSYuQrmklIQf07YpXFK7FV1aU	false	sufficient binding region:80-340	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9UIS9	uniprotkb:Q07021	intact:EBI-867196|uniprotkb:K7ELI2|uniprotkb:Q9UNZ9|uniprotkb:K7EQZ4|uniprotkb:K7ESN0|uniprotkb:A4UTZ0|uniprotkb:O15248|uniprotkb:O95241|uniprotkb:Q7Z7B5|uniprotkb:Q8N4W4|uniprotkb:Q9UNZ6|uniprotkb:Q9UNZ7|uniprotkb:Q9UNZ8|uniprotkb:B4DXJ5|uniprotkb:E9PEC5|intact:EBI-10977266|ensembl:ENSP00000269468|ensembl:ENSP00000372407|ensembl:ENSP00000467017	intact:EBI-347528|uniprotkb:Q2HXR8|uniprotkb:Q9NNY8|intact:EBI-15990352|ensembl:ENSP00000225698	psi-mi:mbd1_human(display_long)|uniprotkb:CXXC3(gene name synonym)|uniprotkb:Methyl-CpG-binding protein MBD1(gene name synonym)|uniprotkb:Protein containing methyl-CpG-binding domain 1(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 3(gene name synonym)|uniprotkb:MBD1(gene name)|psi-mi:MBD1(display_short)|uniprotkb:PCM1(gene name synonym)	psi-mi:c1qbp_human(display_long)|uniprotkb:C1QBP(gene name)|psi-mi:C1QBP(display_short)|uniprotkb:GC1QBP(gene name synonym)|uniprotkb:HABP1(gene name synonym)|uniprotkb:SF2P32(gene name synonym)|uniprotkb:Glycoprotein gC1qBP(gene name synonym)|uniprotkb:Hyaluronan-binding protein 1(gene name synonym)|uniprotkb:Mitochondrial matrix protein p32(gene name synonym)|uniprotkb:p33(gene name synonym)|uniprotkb:ASF/SF2-associated protein p32(gene name synonym)|uniprotkb:gC1q-R protein(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512746|imex:IM-28561-1697	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001191065.1|refseq:NP_001191068.1|refseq:NP_001191071.1|refseq:NP_001191072.1|refseq:NP_001191080.1|refseq:NP_002375.1|refseq:NP_056669.2|refseq:NP_056670.2|refseq:NP_056671.2|refseq:NP_056723.2|refseq:XP_011524295.1|refseq:XP_016881249.1|refseq:XP_016881259.1|refseq:XP_016881260.1|refseq:XP_016881265.1|refseq:XP_011524296.1|refseq:XP_011524308.1|refseq:NP_001191066.1|refseq:NP_001191067.1|refseq:NP_001191069.1|refseq:NP_001191070.1|refseq:XP_005258328.1|ensembl:ENSG00000141644(gene)|ensembl:ENST00000269468(transcript)|ensembl:ENST00000382948(transcript)|ensembl:ENST00000591416(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0010385"(double-stranded methylated DNA binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032355"(response to estradiol)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR016177(DNA-binding, integrase-type)|mint:Q9UIS9|rcsb pdb:1D9N|rcsb pdb:1IG4|rcsb pdb:4D4W|rcsb pdb:5W9Q|rcsb pdb:6D1T|reactome:R-HSA-3899300	refseq:NP_001203.1|dip:DIP-31164N|ensembl:ENSG00000108561(gene)|ensembl:ENST00000225698(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005540"(hyaluronic acid binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006397"(mRNA processing)|go:"GO:0006915"(apoptotic process)|go:"GO:0006955"(immune response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0008494"(translation activator activity)|go:"GO:0009986"(cell surface)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0030449"(regulation of complement activation)|go:"GO:0030984"(kininogen binding)|go:"GO:0031690"(adrenergic receptor binding)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0039534"(negative regulation of MDA-5 signaling pathway)|go:"GO:0039536"(negative regulation of RIG-I signaling pathway)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0042256"(mature ribosome assembly)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050687"(negative regulation of defense response to virus)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070131"(positive regulation of mitochondrial translation)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0097177"(mitochondrial ribosome binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:2000510"(positive regulation of dendritic cell chemotaxis)|interpro:IPR003428(Mitochondrial glycoprotein)|interpro:IPR036561|mint:Q07021|rcsb pdb:1P32|rcsb pdb:3RPX|rcsb pdb:6SZW|reactome:R-HSA-111471|go:"GO:0005886"(plasma membrane)|reactome:R-HSA-8980692|reactome:R-HSA-9013106|reactome:R-HSA-9645722|reactome:R-HSA-140837	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:I6StIYNuO8jT6ZR1YxoZnzDrP/I9606	rogid:NfZ31HjbYZxd8UQKRXczhpc306E9606	rigid:ZT1wNnm7ZSWHv6Al6+bEynoRlx0	false	sufficient binding region:80-340	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9UIS9	uniprotkb:Q9UM47	intact:EBI-867196|uniprotkb:K7ELI2|uniprotkb:Q9UNZ9|uniprotkb:K7EQZ4|uniprotkb:K7ESN0|uniprotkb:A4UTZ0|uniprotkb:O15248|uniprotkb:O95241|uniprotkb:Q7Z7B5|uniprotkb:Q8N4W4|uniprotkb:Q9UNZ6|uniprotkb:Q9UNZ7|uniprotkb:Q9UNZ8|uniprotkb:B4DXJ5|uniprotkb:E9PEC5|intact:EBI-10977266|ensembl:ENSP00000269468|ensembl:ENSP00000372407|ensembl:ENSP00000467017	intact:EBI-1236377|uniprotkb:Q9UEB3|uniprotkb:Q9UPL3|uniprotkb:Q9Y6L8|ensembl:ENSP00000263388	psi-mi:mbd1_human(display_long)|uniprotkb:CXXC3(gene name synonym)|uniprotkb:Methyl-CpG-binding protein MBD1(gene name synonym)|uniprotkb:Protein containing methyl-CpG-binding domain 1(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 3(gene name synonym)|uniprotkb:MBD1(gene name)|psi-mi:MBD1(display_short)|uniprotkb:PCM1(gene name synonym)	psi-mi:notc3_human(display_long)|uniprotkb:NOTCH3(gene name)|psi-mi:NOTCH3(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512911|imex:IM-28561-1225	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001191065.1|refseq:NP_001191068.1|refseq:NP_001191071.1|refseq:NP_001191072.1|refseq:NP_001191080.1|refseq:NP_002375.1|refseq:NP_056669.2|refseq:NP_056670.2|refseq:NP_056671.2|refseq:NP_056723.2|refseq:XP_011524295.1|refseq:XP_016881249.1|refseq:XP_016881259.1|refseq:XP_016881260.1|refseq:XP_016881265.1|refseq:XP_011524296.1|refseq:XP_011524308.1|refseq:NP_001191066.1|refseq:NP_001191067.1|refseq:NP_001191069.1|refseq:NP_001191070.1|refseq:XP_005258328.1|ensembl:ENSG00000141644(gene)|ensembl:ENST00000269468(transcript)|ensembl:ENST00000382948(transcript)|ensembl:ENST00000591416(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0010385"(double-stranded methylated DNA binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032355"(response to estradiol)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR016177(DNA-binding, integrase-type)|mint:Q9UIS9|rcsb pdb:1D9N|rcsb pdb:1IG4|rcsb pdb:4D4W|rcsb pdb:5W9Q|rcsb pdb:6D1T|reactome:R-HSA-3899300	refseq:NP_000426.2|ensembl:ENSP00000263388|dip:DIP-39827N|ensembl:ENSG00000074181(gene)|ensembl:ENST00000263388(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0009986"(cell surface)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043235"(receptor complex)|go:"GO:0045296"(cadherin binding)|go:"GO:0050793"(regulation of developmental process)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000800(Notch region)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002110(Ankyrin)|interpro:IPR008297(Notch)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR010660(Notch, NOD region)|interpro:IPR011656(Notch, NODP region)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR018097|interpro:IPR020683|interpro:IPR022331|interpro:IPR024600|interpro:IPR035993|interpro:IPR036770|mint:Q9UM47|rcsb pdb:4ZLP|rcsb pdb:5CZV|rcsb pdb:5CZX|rcsb pdb:6WQU|reactome:R-HSA-1912399|reactome:R-HSA-1912408|reactome:R-HSA-1912420|reactome:R-HSA-350054|reactome:R-HSA-5083630|reactome:R-HSA-9013507|reactome:R-HSA-9013508|reactome:R-HSA-9017802	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:I6StIYNuO8jT6ZR1YxoZnzDrP/I9606	rogid:hOarWT2DBhNVF6AhV/z+NqLCEv49606	rigid:5icPLzFgVs2ZuaRVbtfwE0WPNjo	false	sufficient binding region:80-340	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9UIS9	uniprotkb:P46531	intact:EBI-867196|uniprotkb:K7ELI2|uniprotkb:Q9UNZ9|uniprotkb:K7EQZ4|uniprotkb:K7ESN0|uniprotkb:A4UTZ0|uniprotkb:O15248|uniprotkb:O95241|uniprotkb:Q7Z7B5|uniprotkb:Q8N4W4|uniprotkb:Q9UNZ6|uniprotkb:Q9UNZ7|uniprotkb:Q9UNZ8|uniprotkb:B4DXJ5|uniprotkb:E9PEC5|intact:EBI-10977266|ensembl:ENSP00000269468|ensembl:ENSP00000372407|ensembl:ENSP00000467017	intact:EBI-636374|uniprotkb:Q59ED8|uniprotkb:Q5SXM3|intact:EBI-28989124|ensembl:ENSP00000498587	psi-mi:mbd1_human(display_long)|uniprotkb:CXXC3(gene name synonym)|uniprotkb:Methyl-CpG-binding protein MBD1(gene name synonym)|uniprotkb:Protein containing methyl-CpG-binding domain 1(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 3(gene name synonym)|uniprotkb:MBD1(gene name)|psi-mi:MBD1(display_short)|uniprotkb:PCM1(gene name synonym)	psi-mi:notc1_human(display_long)|uniprotkb:Translocation-associated notch protein TAN-1(gene name synonym)|uniprotkb:NOTCH1(gene name)|psi-mi:NOTCH1(display_short)|uniprotkb:TAN1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512902|imex:IM-28561-591	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001191065.1|refseq:NP_001191068.1|refseq:NP_001191071.1|refseq:NP_001191072.1|refseq:NP_001191080.1|refseq:NP_002375.1|refseq:NP_056669.2|refseq:NP_056670.2|refseq:NP_056671.2|refseq:NP_056723.2|refseq:XP_011524295.1|refseq:XP_016881249.1|refseq:XP_016881259.1|refseq:XP_016881260.1|refseq:XP_016881265.1|refseq:XP_011524296.1|refseq:XP_011524308.1|refseq:NP_001191066.1|refseq:NP_001191067.1|refseq:NP_001191069.1|refseq:NP_001191070.1|refseq:XP_005258328.1|ensembl:ENSG00000141644(gene)|ensembl:ENST00000269468(transcript)|ensembl:ENST00000382948(transcript)|ensembl:ENST00000591416(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0010385"(double-stranded methylated DNA binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032355"(response to estradiol)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR016177(DNA-binding, integrase-type)|mint:Q9UIS9|rcsb pdb:1D9N|rcsb pdb:1IG4|rcsb pdb:4D4W|rcsb pdb:5W9Q|rcsb pdb:6D1T|reactome:R-HSA-3899300	refseq:NP_060087.3|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007221"(positive regulation of transcription of Notch receptor target)|go:"GO:0005912"(adherens junction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007386"(compartment pattern specification)|go:"GO:0007411"(axon guidance)|go:"GO:0007440"(foregut morphogenesis)|go:"GO:0007492"(endoderm development)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009912"(auditory receptor cell fate commitment)|go:"GO:0009986"(cell surface)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0014031"(mesenchymal cell development)|go:"GO:0014807"(regulation of somitogenesis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0021515"(cell differentiation in spinal cord)|go:"GO:0021915"(neural tube development)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030900"(forebrain development)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035148"(tube formation)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042802"(identical protein binding)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045603"(positive regulation of endothelial cell differentiation)|go:"GO:0045608"(negative regulation of inner ear auditory receptor cell differentiation)|go:"GO:0045618"(positive regulation of keratinocyte differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045955"(negative regulation of calcium ion-dependent exocytosis)|go:"GO:0045967"(negative regulation of growth rate)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046533"(negative regulation of photoreceptor cell differentiation)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048103"(somatic stem cell division)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0048715"(negative regulation of oligodendrocyte differentiation)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060253"(negative regulation of glial cell proliferation)|go:"GO:0060271"(cilium assembly)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060354"(negative regulation of cell adhesion molecule production)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060528"(secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development)|go:"GO:0060740"(prostate gland epithelium morphogenesis)|go:"GO:0060768"(regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0060842"(arterial endothelial cell differentiation)|go:"GO:0060843"(venous endothelial cell differentiation)|go:"GO:0060948"(cardiac vascular smooth muscle cell development)|go:"GO:0060956"(endocardial cell differentiation)|go:"GO:0060979"(vasculogenesis involved in coronary vascular morphogenesis)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0061314"(Notch signaling involved in heart development)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0072144"(glomerular mesangial cell development)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0061384"(heart trabecula morphogenesis)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:1901201"(regulation of extracellular matrix assembly)|go:"GO:0062043"(positive regulation of cardiac epithelial to mesenchymal transition)|go:"GO:0070168"(negative regulation of biomineral tissue development)|go:"GO:1902263"(apoptotic process involved in embryonic digit morphogenesis)|go:"GO:1902339"(positive regulation of apoptotic process involved in morphogenesis)|go:"GO:1903849"(positive regulation of aorta morphogenesis)|go:"GO:2000048"(negative regulation of cell-cell adhesion mediated by cadherin)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2000974"(negative regulation of pro-B cell differentiation)|go:"GO:2001027"(negative regulation of endothelial cell chemotaxis)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000800(Notch region)|go:"GO:0070986"(left/right axis specification)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002110(Ankyrin)|interpro:IPR008297(Notch)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR010660(Notch, NOD region)|interpro:IPR011656(Notch, NODP region)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR018097|interpro:IPR020683|interpro:IPR022362|interpro:IPR024600|go:"GO:0071372"(cellular response to follicle-stimulating hormone stimulus)|interpro:IPR035993|interpro:IPR036770|mint:P46531|rcsb pdb:1PB5|rcsb pdb:1TOZ|rcsb pdb:1YYH|rcsb pdb:2F8X|rcsb pdb:2F8Y|rcsb pdb:2HE0|go:"GO:0072017"(distal tubule development)|go:"GO:0072044"(collecting duct development)|rcsb pdb:2VJ3|rcsb pdb:3ETO|rcsb pdb:3I08|rcsb pdb:3L95|rcsb pdb:3NBN|rcsb pdb:3V79|rcsb pdb:4CUD|rcsb pdb:4CUE|rcsb pdb:4CUF|rcsb pdb:4D0E|rcsb pdb:4D0F|rcsb pdb:5FM9|rcsb pdb:5FMA|rcsb pdb:5KZO|rcsb pdb:5L0R|rcsb pdb:5UB5|rcsb pdb:6IDF|rcsb pdb:6PY8|reactome:R-HSA-1912399|reactome:R-HSA-1912408|reactome:R-HSA-1912420|reactome:R-HSA-210744|reactome:R-HSA-2122947|reactome:R-HSA-2122948|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2660826|reactome:R-HSA-2691232|reactome:R-HSA-2894862|reactome:R-HSA-350054|reactome:R-HSA-5083630|reactome:R-HSA-8941856|reactome:R-HSA-9013508|reactome:R-HSA-9013695|ensembl:ENSG00000148400(gene)|ensembl:ENST00000651671(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001708"(cell fate specification)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001889"(liver development)|go:"GO:0001947"(heart looping)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002193"(MAML1-RBP-Jkappa- ICN1 complex)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003157"(endocardium development)|go:"GO:0003160"(endocardium morphogenesis)|go:"GO:0003162"(atrioventricular node development)|go:"GO:0003169"(coronary vein morphogenesis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003182"(coronary sinus valve morphogenesis)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0003192"(mitral valve formation)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003207"(cardiac chamber formation)|go:"GO:0003208"(cardiac ventricle morphogenesis)|go:"GO:0003209"(cardiac atrium morphogenesis)|go:"GO:0003213"(cardiac right atrium morphogenesis)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0003219"(cardiac right ventricle formation)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003241"(growth involved in heart morphogenesis)|go:"GO:0003252"(negative regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0003256"(regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation)|go:"GO:0003270"(Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation)|go:"GO:0003273"(cell migration involved in endocardial cushion formation)|go:"GO:0003332"(negative regulation of extracellular matrix constituent secretion)|go:"GO:0003344"(pericardium morphogenesis)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005112"(Notch binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|dip:DIP-29919N|ensembl:ENSP00000498587	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:I6StIYNuO8jT6ZR1YxoZnzDrP/I9606	rogid:yRAjMjynnyZ7ANlk2eulodpS4P09606	rigid:aZre1/1rdfFTHQDX1hU8vxjHI5w	false	sufficient binding region:80-340	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9UIS9	uniprotkb:Q99435	intact:EBI-867196|uniprotkb:K7ELI2|uniprotkb:Q9UNZ9|uniprotkb:K7EQZ4|uniprotkb:K7ESN0|uniprotkb:A4UTZ0|uniprotkb:O15248|uniprotkb:O95241|uniprotkb:Q7Z7B5|uniprotkb:Q8N4W4|uniprotkb:Q9UNZ6|uniprotkb:Q9UNZ7|uniprotkb:Q9UNZ8|uniprotkb:B4DXJ5|uniprotkb:E9PEC5|intact:EBI-10977266|ensembl:ENSP00000269468|ensembl:ENSP00000372407|ensembl:ENSP00000467017	intact:EBI-946274|intact:EBI-2845314|uniprotkb:B7Z2U7|uniprotkb:B7Z5Q4|uniprotkb:B7Z9J5|uniprotkb:B7Z9U3|uniprotkb:Q96JS2|ensembl:ENSP00000390680|ensembl:ENSP00000394612	psi-mi:mbd1_human(display_long)|uniprotkb:CXXC3(gene name synonym)|uniprotkb:Methyl-CpG-binding protein MBD1(gene name synonym)|uniprotkb:Protein containing methyl-CpG-binding domain 1(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 3(gene name synonym)|uniprotkb:MBD1(gene name)|psi-mi:MBD1(display_short)|uniprotkb:PCM1(gene name synonym)	psi-mi:nell2_human(display_long)|uniprotkb:NELL2(gene name)|psi-mi:NELL2(display_short)|uniprotkb:NRP2(gene name synonym)|uniprotkb:NEL-like protein 2(gene name synonym)|uniprotkb:Nel-related protein 2(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512893|imex:IM-28561-1707	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001191065.1|refseq:NP_001191068.1|refseq:NP_001191071.1|refseq:NP_001191072.1|refseq:NP_001191080.1|refseq:NP_002375.1|refseq:NP_056669.2|refseq:NP_056670.2|refseq:NP_056671.2|refseq:NP_056723.2|refseq:XP_011524295.1|refseq:XP_016881249.1|refseq:XP_016881259.1|refseq:XP_016881260.1|refseq:XP_016881265.1|refseq:XP_011524296.1|refseq:XP_011524308.1|refseq:NP_001191066.1|refseq:NP_001191067.1|refseq:NP_001191069.1|refseq:NP_001191070.1|refseq:XP_005258328.1|ensembl:ENSG00000141644(gene)|ensembl:ENST00000269468(transcript)|ensembl:ENST00000382948(transcript)|ensembl:ENST00000591416(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0010385"(double-stranded methylated DNA binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032355"(response to estradiol)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR016177(DNA-binding, integrase-type)|mint:Q9UIS9|rcsb pdb:1D9N|rcsb pdb:1IG4|rcsb pdb:4D4W|rcsb pdb:5W9Q|rcsb pdb:6D1T|reactome:R-HSA-3899300	refseq:NP_001138579.1|refseq:NP_001138580.1|refseq:NP_001138581.1|refseq:NP_001138582.1|refseq:NP_006150.1|refseq:XP_011536698.1|refseq:XP_005268962.1|dip:DIP-49927N|ensembl:ENSG00000184613(gene)|ensembl:ENST00000429094(transcript)|ensembl:ENST00000452445(transcript)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0008201"(heparin binding)|go:"GO:0070050"(neuron cellular homeostasis)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR001791(Laminin G)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR018097|mint:Q99435|rcsb pdb:6POG|reactome:R-HSA-428542	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:I6StIYNuO8jT6ZR1YxoZnzDrP/I9606	rogid:/NYlmX9iC3H17WXd+u97CVwOD7c9606	rigid:dtW9ghODJl1SV1lMlKJh7oVawpw	false	sufficient binding region:80-340	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9UIS9	uniprotkb:Q92832	intact:EBI-867196|uniprotkb:K7ELI2|uniprotkb:Q9UNZ9|uniprotkb:K7EQZ4|uniprotkb:K7ESN0|uniprotkb:A4UTZ0|uniprotkb:O15248|uniprotkb:O95241|uniprotkb:Q7Z7B5|uniprotkb:Q8N4W4|uniprotkb:Q9UNZ6|uniprotkb:Q9UNZ7|uniprotkb:Q9UNZ8|uniprotkb:B4DXJ5|uniprotkb:E9PEC5|intact:EBI-10977266|ensembl:ENSP00000269468|ensembl:ENSP00000372407|ensembl:ENSP00000467017	intact:EBI-947754|uniprotkb:Q4VB91|uniprotkb:Q4VB90|uniprotkb:B2CKC1|uniprotkb:Q9Y472|uniprotkb:Q6NSY8|ensembl:ENSP00000349654	psi-mi:mbd1_human(display_long)|uniprotkb:CXXC3(gene name synonym)|uniprotkb:Methyl-CpG-binding protein MBD1(gene name synonym)|uniprotkb:Protein containing methyl-CpG-binding domain 1(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 3(gene name synonym)|uniprotkb:MBD1(gene name)|psi-mi:MBD1(display_short)|uniprotkb:PCM1(gene name synonym)	psi-mi:nell1_human(display_long)|uniprotkb:NEL-like protein 1(gene name synonym)|uniprotkb:Nel-related protein 1(gene name synonym)|uniprotkb:NELL1(gene name)|psi-mi:NELL1(display_short)|uniprotkb:NRP1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512884|imex:IM-28561-1031	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001191065.1|refseq:NP_001191068.1|refseq:NP_001191071.1|refseq:NP_001191072.1|refseq:NP_001191080.1|refseq:NP_002375.1|refseq:NP_056669.2|refseq:NP_056670.2|refseq:NP_056671.2|refseq:NP_056723.2|refseq:XP_011524295.1|refseq:XP_016881249.1|refseq:XP_016881259.1|refseq:XP_016881260.1|refseq:XP_016881265.1|refseq:XP_011524296.1|refseq:XP_011524308.1|refseq:NP_001191066.1|refseq:NP_001191067.1|refseq:NP_001191069.1|refseq:NP_001191070.1|refseq:XP_005258328.1|ensembl:ENSG00000141644(gene)|ensembl:ENST00000269468(transcript)|ensembl:ENST00000382948(transcript)|ensembl:ENST00000591416(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0010385"(double-stranded methylated DNA binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032355"(response to estradiol)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR016177(DNA-binding, integrase-type)|mint:Q9UIS9|rcsb pdb:1D9N|rcsb pdb:1IG4|rcsb pdb:4D4W|rcsb pdb:5W9Q|rcsb pdb:6D1T|reactome:R-HSA-3899300	refseq:NP_006148.2|refseq:NP_963845.1|refseq:NP_001275642.1|refseq:NP_001275643.1|ensembl:ENSG00000165973(gene)|ensembl:ENST00000357134(transcript)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0007399"(nervous system development)|go:"GO:0008201"(heparin binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0030154"(cell differentiation)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0033689"(negative regulation of osteoblast proliferation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:1903363"(negative regulation of cellular protein catabolic process)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR001791(Laminin G)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR018097|interpro:IPR024731|mint:Q92832|rcsb pdb:6POL	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:I6StIYNuO8jT6ZR1YxoZnzDrP/I9606	rogid:nC7vtd2PeL7K7QjSVJDoDJE3owk9606	rigid:Xdc/WaoV7O00mLOpRg5Mh88NzRk	false	sufficient binding region:80-340	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9UIS9	uniprotkb:O75095	intact:EBI-867196|uniprotkb:K7ELI2|uniprotkb:Q9UNZ9|uniprotkb:K7EQZ4|uniprotkb:K7ESN0|uniprotkb:A4UTZ0|uniprotkb:O15248|uniprotkb:O95241|uniprotkb:Q7Z7B5|uniprotkb:Q8N4W4|uniprotkb:Q9UNZ6|uniprotkb:Q9UNZ7|uniprotkb:Q9UNZ8|uniprotkb:B4DXJ5|uniprotkb:E9PEC5|intact:EBI-10977266|ensembl:ENSP00000269468|ensembl:ENSP00000372407|ensembl:ENSP00000467017	intact:EBI-947597|uniprotkb:Q5VV39|uniprotkb:Q4AC86|ensembl:ENSP00000348982	psi-mi:mbd1_human(display_long)|uniprotkb:CXXC3(gene name synonym)|uniprotkb:Methyl-CpG-binding protein MBD1(gene name synonym)|uniprotkb:Protein containing methyl-CpG-binding domain 1(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 3(gene name synonym)|uniprotkb:MBD1(gene name)|psi-mi:MBD1(display_short)|uniprotkb:PCM1(gene name synonym)	psi-mi:megf6_human(display_long)|uniprotkb:MEGF6(gene name)|psi-mi:MEGF6(display_short)|uniprotkb:EGFL3(gene name synonym)|uniprotkb:KIAA0815(gene name synonym)|uniprotkb:Epidermal growth factor-like protein 3(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512875|imex:IM-28561-589	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001191065.1|refseq:NP_001191068.1|refseq:NP_001191071.1|refseq:NP_001191072.1|refseq:NP_001191080.1|refseq:NP_002375.1|refseq:NP_056669.2|refseq:NP_056670.2|refseq:NP_056671.2|refseq:NP_056723.2|refseq:XP_011524295.1|refseq:XP_016881249.1|refseq:XP_016881259.1|refseq:XP_016881260.1|refseq:XP_016881265.1|refseq:XP_011524296.1|refseq:XP_011524308.1|refseq:NP_001191066.1|refseq:NP_001191067.1|refseq:NP_001191069.1|refseq:NP_001191070.1|refseq:XP_005258328.1|ensembl:ENSG00000141644(gene)|ensembl:ENST00000269468(transcript)|ensembl:ENST00000382948(transcript)|ensembl:ENST00000591416(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0010385"(double-stranded methylated DNA binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032355"(response to estradiol)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR016177(DNA-binding, integrase-type)|mint:Q9UIS9|rcsb pdb:1D9N|rcsb pdb:1IG4|rcsb pdb:4D4W|rcsb pdb:5W9Q|rcsb pdb:6D1T|reactome:R-HSA-3899300	refseq:NP_001400.3|ensembl:ENSG00000162591(gene)|ensembl:ENST00000356575(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002049(EGF-like, laminin)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011489(EMI)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR018097|mint:O75095	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:I6StIYNuO8jT6ZR1YxoZnzDrP/I9606	rogid:/4HcLiv4UEW2qmvoV2OTj110y1I9606	rigid:xE7nEB2/LvrnOo3L1btgT0b92Ps	false	sufficient binding region:80-340	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9UIS9	uniprotkb:Q00325	intact:EBI-867196|uniprotkb:K7ELI2|uniprotkb:Q9UNZ9|uniprotkb:K7EQZ4|uniprotkb:K7ESN0|uniprotkb:A4UTZ0|uniprotkb:O15248|uniprotkb:O95241|uniprotkb:Q7Z7B5|uniprotkb:Q8N4W4|uniprotkb:Q9UNZ6|uniprotkb:Q9UNZ7|uniprotkb:Q9UNZ8|uniprotkb:B4DXJ5|uniprotkb:E9PEC5|intact:EBI-10977266|ensembl:ENSP00000269468|ensembl:ENSP00000372407|ensembl:ENSP00000467017	intact:EBI-358549|uniprotkb:Q96A03|intact:EBI-28967087|ensembl:ENSP00000228318|ensembl:ENSP00000447310|uniprotkb:Q7Z7N7|uniprotkb:B3KS34	psi-mi:mbd1_human(display_long)|uniprotkb:CXXC3(gene name synonym)|uniprotkb:Methyl-CpG-binding protein MBD1(gene name synonym)|uniprotkb:Protein containing methyl-CpG-binding domain 1(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 3(gene name synonym)|uniprotkb:MBD1(gene name)|psi-mi:MBD1(display_short)|uniprotkb:PCM1(gene name synonym)	psi-mi:mpcp_human(display_long)|uniprotkb:SLC25A3(gene name)|psi-mi:SLC25A3(display_short)|uniprotkb:PHC(gene name synonym)|uniprotkb:OK/SW-cl.48(orf name)|uniprotkb:Phosphate transport protein(gene name synonym)|uniprotkb:Solute carrier family 25 member 3(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512929|imex:IM-28561-1505	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001191065.1|refseq:NP_001191068.1|refseq:NP_001191071.1|refseq:NP_001191072.1|refseq:NP_001191080.1|refseq:NP_002375.1|refseq:NP_056669.2|refseq:NP_056670.2|refseq:NP_056671.2|refseq:NP_056723.2|refseq:XP_011524295.1|refseq:XP_016881249.1|refseq:XP_016881259.1|refseq:XP_016881260.1|refseq:XP_016881265.1|refseq:XP_011524296.1|refseq:XP_011524308.1|refseq:NP_001191066.1|refseq:NP_001191067.1|refseq:NP_001191069.1|refseq:NP_001191070.1|refseq:XP_005258328.1|ensembl:ENSG00000141644(gene)|ensembl:ENST00000269468(transcript)|ensembl:ENST00000382948(transcript)|ensembl:ENST00000591416(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0010385"(double-stranded methylated DNA binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032355"(response to estradiol)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR016177(DNA-binding, integrase-type)|mint:Q9UIS9|rcsb pdb:1D9N|rcsb pdb:1IG4|rcsb pdb:4D4W|rcsb pdb:5W9Q|rcsb pdb:6D1T|reactome:R-HSA-3899300	ensembl:ENST00000188376|ensembl:ENSP00000188376|ensembl:ENSP00000228318|ensembl:ENST00000401722|ensembl:ENSP00000383898|ensembl:ENST00000549338|ensembl:ENSP00000447740|ensembl:ENSP00000447310|ensembl:ENST00000552981|ensembl:ENSP00000448708|refseq:NP_002626.1|refseq:NP_005879.1|refseq:NP_998776.1|ensembl:ENSG00000075415(gene)|ensembl:ENST00000228318(transcript)|ensembl:ENST00000551917(transcript)|go:"GO:0005315"(inorganic phosphate transmembrane transporter activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0015317"("phosphate:proton symporter activity")|go:"GO:0016020"(membrane)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0035435"(phosphate ion transmembrane transport)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990547"(mitochondrial phosphate ion transmembrane transport)|interpro:IPR018108|interpro:IPR023395|interpro:IPR044677|mint:Q00325	-	-	crc64:78714C85931B22D5	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:I6StIYNuO8jT6ZR1YxoZnzDrP/I9606	rogid:f8THTDwNPyGowC9gCT9ZsizQ6qs9606	rigid:Rz1qyiq4ClvJ7eW9HKdoK8HYeZs	false	sufficient binding region:80-340	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O75592	uniprotkb:P24592	intact:EBI-1043774|uniprotkb:Q5JSX8|uniprotkb:Q5VZN6|uniprotkb:Q6PIB6|uniprotkb:Q9UQ11|uniprotkb:Q9Y6E4|uniprotkb:A6NJC6|ensembl:ENSP00000444596	intact:EBI-947015|uniprotkb:Q14492|ensembl:ENSP00000301464	psi-mi:mycb2_human(display_long)|uniprotkb:MYCBP2(gene name)|psi-mi:MYCBP2(display_short)|uniprotkb:KIAA0916(gene name synonym)|uniprotkb:PAM(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)	psi-mi:ibp6_human(display_long)|uniprotkb:IGFBP6(gene name)|psi-mi:IGFBP6(display_short)|uniprotkb:IBP6(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513105|imex:IM-28561-1233	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055872.4|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003646(Bacterial SH3-like region)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR012983(PHR)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR038648|mint:O75592|rcsb pdb:5O6C|rcsb pdb:6T7F|ensembl:ENSG00000005810(gene)|ensembl:ENST00000544440(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|dip:DIP-28142N	refseq:NP_002169.1|ensembl:ENSG00000167779(gene)|ensembl:ENST00000301464(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001968"(fibronectin binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0007165"(signal transduction)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016477"(cell migration)|go:"GO:0031994"(insulin-like growth factor I binding)|go:"GO:0031995"(insulin-like growth factor II binding)|go:"GO:0042568"(insulin-like growth factor binary complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043567"(regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR000716(Thyroglobulin type-1)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR022321|interpro:IPR022326|interpro:IPR036857|mint:P24592|rcsb pdb:1RMJ|reactome:R-HSA-381426	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:AR3FR/zd48HkVinEfdT17ItGkbU9606	rogid:BSHm7yEGH0P8gnrvluEffCEeyl09606	rigid:HRHNh4ZFFIh9G72Ycv+iSNSSgwI	false	sufficient binding region:2540-3006	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9UIS9	uniprotkb:P24821	intact:EBI-867196|uniprotkb:K7ELI2|uniprotkb:Q9UNZ9|uniprotkb:K7EQZ4|uniprotkb:K7ESN0|uniprotkb:A4UTZ0|uniprotkb:O15248|uniprotkb:O95241|uniprotkb:Q7Z7B5|uniprotkb:Q8N4W4|uniprotkb:Q9UNZ6|uniprotkb:Q9UNZ7|uniprotkb:Q9UNZ8|uniprotkb:B4DXJ5|uniprotkb:E9PEC5|intact:EBI-10977266|ensembl:ENSP00000269468|ensembl:ENSP00000372407|ensembl:ENSP00000467017	intact:EBI-9979894|uniprotkb:C9IYT7|uniprotkb:C9J575|uniprotkb:C9J6D9|uniprotkb:C9J848|uniprotkb:Q14583|uniprotkb:Q15567|uniprotkb:Q5T7S3|ensembl:ENSP00000265131	psi-mi:mbd1_human(display_long)|uniprotkb:CXXC3(gene name synonym)|uniprotkb:Methyl-CpG-binding protein MBD1(gene name synonym)|uniprotkb:Protein containing methyl-CpG-binding domain 1(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 3(gene name synonym)|uniprotkb:MBD1(gene name)|psi-mi:MBD1(display_short)|uniprotkb:PCM1(gene name synonym)	psi-mi:tena_human(display_long)|uniprotkb:TNC(gene name)|psi-mi:TNC(display_short)|uniprotkb:HXB(gene name synonym)|uniprotkb:Cytotactin(gene name synonym)|uniprotkb:GMEM(gene name synonym)|uniprotkb:GP 150-225(gene name synonym)|uniprotkb:Glioma-associated-extracellular matrix antigen(gene name synonym)|uniprotkb:Hexabrachion(gene name synonym)|uniprotkb:JI(gene name synonym)|uniprotkb:Myotendinous antigen(gene name synonym)|uniprotkb:Neuronectin(gene name synonym)|uniprotkb:Tenascin-C(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512947|imex:IM-28561-851	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001191065.1|refseq:NP_001191068.1|refseq:NP_001191071.1|refseq:NP_001191072.1|refseq:NP_001191080.1|refseq:NP_002375.1|refseq:NP_056669.2|refseq:NP_056670.2|refseq:NP_056671.2|refseq:NP_056723.2|refseq:XP_011524295.1|refseq:XP_016881249.1|refseq:XP_016881259.1|refseq:XP_016881260.1|refseq:XP_016881265.1|refseq:XP_011524296.1|refseq:XP_011524308.1|refseq:NP_001191066.1|refseq:NP_001191067.1|refseq:NP_001191069.1|refseq:NP_001191070.1|refseq:XP_005258328.1|ensembl:ENSG00000141644(gene)|ensembl:ENST00000269468(transcript)|ensembl:ENST00000382948(transcript)|ensembl:ENST00000591416(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0010385"(double-stranded methylated DNA binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032355"(response to estradiol)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR016177(DNA-binding, integrase-type)|mint:Q9UIS9|rcsb pdb:1D9N|rcsb pdb:1IG4|rcsb pdb:4D4W|rcsb pdb:5W9Q|rcsb pdb:6D1T|reactome:R-HSA-3899300	refseq:NP_002151.2|refseq:XP_005252029.1|refseq:XP_005252031.1|refseq:XP_005252032.1|go:"GO:0005604"(basement membrane)|go:"GO:0005614"(interstitial matrix)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009611"(response to wounding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014012"(peripheral nervous system axon regeneration)|go:"GO:0016020"(membrane)|go:"GO:0042060"(wound healing)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0005576"(extracellular region)|ensembl:ENSG00000041982(gene)|ensembl:ENST00000350763(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0005201"(extracellular matrix structural constituent)|reactome:R-HSA-3000178|reactome:R-HSA-381426|reactome:R-HSA-8957275|reactome:R-HSA-3000170|interpro:IPR036056|interpro:IPR036116|interpro:IPR041161|mint:P24821|rcsb pdb:1TEN|rcsb pdb:2RB8|rcsb pdb:2RBL|rcsb pdb:5R5T|rcsb pdb:5R5U|rcsb pdb:5R5V|rcsb pdb:5R5W|rcsb pdb:5R5X|rcsb pdb:5R5Y|rcsb pdb:5R5Z|rcsb pdb:5R60|rcsb pdb:5R61|rcsb pdb:5R62|rcsb pdb:5R63|interpro:IPR033078|rcsb pdb:6BRB|rcsb pdb:6QNV|reactome:R-HSA-216083|go:"GO:0045471"(response to ethanol)|interpro:IPR013111(EGF, extracellular)|go:"GO:0045545"(syndecan binding)|interpro:IPR013783(Immunoglobulin-like fold)|go:"GO:0060447"(bud outgrowth involved in lung branching)|go:"GO:0060739"(mesenchymal-epithelial cell signaling involved in prostate gland development)|go:"GO:0060740"(prostate gland epithelium morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071305"(cellular response to vitamin D)|go:"GO:0071774"(response to fibroblast growth factor)|go:"GO:0071799"(cellular response to prostaglandin D stimulus)|go:"GO:0098966"(perisynaptic extracellular matrix)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|refseq:XP_011516931.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:I6StIYNuO8jT6ZR1YxoZnzDrP/I9606	rogid:3V4KLLvsAFOCtJqiGfwPSQkK69g9606	rigid:qx4Twpb4asitugvolXaaCc9fVUE	false	sufficient binding region:80-340	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O75592	uniprotkb:Q16658	intact:EBI-1043774|uniprotkb:Q5JSX8|uniprotkb:Q5VZN6|uniprotkb:Q6PIB6|uniprotkb:Q9UQ11|uniprotkb:Q9Y6E4|uniprotkb:A6NJC6|ensembl:ENSP00000444596	intact:EBI-351076|uniprotkb:Q96IH1|uniprotkb:A6NI89|uniprotkb:Q96IC5|uniprotkb:Q9BRF1|uniprotkb:B2RE97|ensembl:ENSP00000371798	psi-mi:mycb2_human(display_long)|uniprotkb:MYCBP2(gene name)|psi-mi:MYCBP2(display_short)|uniprotkb:KIAA0916(gene name synonym)|uniprotkb:PAM(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)	psi-mi:fscn1_human(display_long)|uniprotkb:FSCN1(gene name)|psi-mi:FSCN1(display_short)|uniprotkb:FAN1(gene name synonym)|uniprotkb:HSN(gene name synonym)|uniprotkb:SNL(gene name synonym)|uniprotkb:Singed-like protein(gene name synonym)|uniprotkb:55 kDa actin-bundling protein(gene name synonym)|uniprotkb:p55(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513087|imex:IM-28561-359	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055872.4|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003646(Bacterial SH3-like region)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR012983(PHR)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR038648|mint:O75592|rcsb pdb:5O6C|rcsb pdb:6T7F|ensembl:ENSG00000005810(gene)|ensembl:ENST00000544440(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|dip:DIP-28142N	go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030046"(parallel actin filament bundle assembly)|go:"GO:0030175"(filopodium)|go:"GO:0030426"(growth cone)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031253"(cell projection membrane)|go:"GO:0032534"(regulation of microvillus assembly)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035089"(establishment of apical/basal cell polarity)|go:"GO:0044393"(microspike)|go:"GO:0045296"(cadherin binding)|go:"GO:0048870"(cell motility)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0090091"(positive regulation of extracellular matrix disassembly)|interpro:IPR008999(Actin_cross-linking)|interpro:IPR010431(Fascin)|interpro:IPR022768|interpro:IPR024703|interpro:IPR030146|mint:Q16658|rcsb pdb:1DFC|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016477"(cell migration)|go:"GO:0030027"(lamellipodium)|go:"GO:0030035"(microspike assembly)|rcsb pdb:3LLP|refseq:NP_003079.1|ensembl:ENSG00000075618(gene)|ensembl:ENST00000382361(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0002102"(podosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005902"(microvillus)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005938"(cell cortex)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0008144"(obsolete drug binding)|rcsb pdb:3P53|rcsb pdb:4GOV|rcsb pdb:4GOY|rcsb pdb:4GP3|rcsb pdb:6B0T|rcsb pdb:6I0Z|rcsb pdb:6I10|rcsb pdb:6I11|rcsb pdb:6I12|rcsb pdb:6I13|rcsb pdb:6I14|rcsb pdb:6I15|rcsb pdb:6I16|rcsb pdb:6I17|rcsb pdb:6I18|reactome:R-HSA-6785807|rcsb pdb:4GP0|dip:DIP-33171N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:AR3FR/zd48HkVinEfdT17ItGkbU9606	rogid:yc9EJDCKGJGGEcEueR/yAY/fxRg9606	rigid:+4CkE3MG0gGwfbW+Y5uLaRv/SEQ	false	sufficient binding region:2540-3006	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O75592	uniprotkb:Q13643	intact:EBI-1043774|uniprotkb:Q5JSX8|uniprotkb:Q5VZN6|uniprotkb:Q6PIB6|uniprotkb:Q9UQ11|uniprotkb:Q9Y6E4|uniprotkb:A6NJC6|ensembl:ENSP00000444596	intact:EBI-741101|ensembl:ENSP00000362107|uniprotkb:Q6I9T0|uniprotkb:Q9BVA2|uniprotkb:D3DPT6	psi-mi:mycb2_human(display_long)|uniprotkb:MYCBP2(gene name)|psi-mi:MYCBP2(display_short)|uniprotkb:KIAA0916(gene name synonym)|uniprotkb:PAM(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)	psi-mi:fhl3_human(display_long)|uniprotkb:FHL3(gene name)|psi-mi:FHL3(display_short)|uniprotkb:SLIM2(gene name synonym)|uniprotkb:Skeletal muscle LIM-protein 2(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513078|imex:IM-28561-357	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055872.4|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003646(Bacterial SH3-like region)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR012983(PHR)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR038648|mint:O75592|rcsb pdb:5O6C|rcsb pdb:6T7F|ensembl:ENSG00000005810(gene)|ensembl:ENST00000544440(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|dip:DIP-28142N	refseq:NP_004459.2|ensembl:ENSG00000183386(gene)|ensembl:ENST00000373016(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005925"(focal adhesion)|go:"GO:0007517"(muscle organ development)|go:"GO:0030018"(Z disc)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0046872"(metal ion binding)|interpro:IPR001781(Zinc finger, LIM-type)|mint:Q13643|rcsb pdb:1WYH|rcsb pdb:2CUQ|rcsb pdb:2EHE|interpro:IPR037987|refseq:NP_001230807.1|dip:DIP-42030N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:AR3FR/zd48HkVinEfdT17ItGkbU9606	rogid:RAo+b/VgFSnHSbgR+zXuxJvypxM9606	rigid:H0auF1nd979NtDXnHYyAlNzPzMs	false	sufficient binding region:2540-3006	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O75592	uniprotkb:Q6PKH6	intact:EBI-1043774|uniprotkb:Q5JSX8|uniprotkb:Q5VZN6|uniprotkb:Q6PIB6|uniprotkb:Q9UQ11|uniprotkb:Q9Y6E4|uniprotkb:A6NJC6|ensembl:ENSP00000444596	intact:EBI-21238179|uniprotkb:Q3YLD4|ensembl:ENSP00000334801|uniprotkb:H0YN69	psi-mi:mycb2_human(display_long)|uniprotkb:MYCBP2(gene name)|psi-mi:MYCBP2(display_short)|uniprotkb:KIAA0916(gene name synonym)|uniprotkb:PAM(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)	psi-mi:dr4l2_human(display_long)|uniprotkb:DHRS4L2(gene name)|psi-mi:DHRS4L2(display_short)|uniprotkb:SDR25C3(gene name synonym)|uniprotkb:Short chain dehydrogenase/reductase family 25C member 3(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513069|imex:IM-28561-789	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055872.4|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003646(Bacterial SH3-like region)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR012983(PHR)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR038648|mint:O75592|rcsb pdb:5O6C|rcsb pdb:6T7F|ensembl:ENSG00000005810(gene)|ensembl:ENST00000544440(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|dip:DIP-28142N	ensembl:ENSG00000187630(gene)|ensembl:ENST00000335125(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0016491"(oxidoreductase activity)|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR020904|interpro:IPR029511|interpro:IPR036291|mint:Q6PKH6	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2021/12/01	rogid:AR3FR/zd48HkVinEfdT17ItGkbU9606	rogid:bb5WA5sAYjItShcKh/zY171GxlA9606	rigid:B30Gn986yV+bTgaceh0RlGnKz5A	false	sufficient binding region:2540-3006	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O75592	uniprotkb:Q9H467	intact:EBI-1043774|uniprotkb:Q5JSX8|uniprotkb:Q5VZN6|uniprotkb:Q6PIB6|uniprotkb:Q9UQ11|uniprotkb:Q9Y6E4|uniprotkb:A6NJC6|ensembl:ENSP00000444596	intact:EBI-1248228|uniprotkb:Q9BWG8|uniprotkb:D3DR88|ensembl:ENSP00000358953	psi-mi:mycb2_human(display_long)|uniprotkb:MYCBP2(gene name)|psi-mi:MYCBP2(display_short)|uniprotkb:KIAA0916(gene name synonym)|uniprotkb:PAM(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)	psi-mi:cued2_human(display_long)|uniprotkb:CUEDC2(gene name)|psi-mi:CUEDC2(display_short)|uniprotkb:C10orf66(gene name synonym)|uniprotkb:HOYS6(orf name)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513060|imex:IM-28561-1709	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055872.4|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003646(Bacterial SH3-like region)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR012983(PHR)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR038648|mint:O75592|rcsb pdb:5O6C|rcsb pdb:6T7F|ensembl:ENSG00000005810(gene)|ensembl:ENST00000544440(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|dip:DIP-28142N	refseq:NP_076945.2|ensembl:ENSG00000107874(gene)|ensembl:ENST00000369937(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010936"(negative regulation of macrophage cytokine production)|go:"GO:0031965"(nuclear membrane)|go:"GO:0043130"(ubiquitin binding)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|interpro:IPR003892(Ubiquitin system component Cue)|interpro:IPR039784|interpro:IPR039805|mint:Q9H467	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:AR3FR/zd48HkVinEfdT17ItGkbU9606	rogid:/iO9kQPGdkbvn6qsyxW8sXG2nr89606	rigid:5ghZlXfY6KCAf6mHoOox0e7tvX8	false	sufficient binding region:2540-3006	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O75592	uniprotkb:P23528	intact:EBI-1043774|uniprotkb:Q5JSX8|uniprotkb:Q5VZN6|uniprotkb:Q6PIB6|uniprotkb:Q9UQ11|uniprotkb:Q9Y6E4|uniprotkb:A6NJC6|ensembl:ENSP00000444596	intact:EBI-352733|uniprotkb:Q53Y87|uniprotkb:Q9UCA2|uniprotkb:B3KUQ1|ensembl:ENSP00000309629|ensembl:ENSP00000432660	psi-mi:mycb2_human(display_long)|uniprotkb:MYCBP2(gene name)|psi-mi:MYCBP2(display_short)|uniprotkb:KIAA0916(gene name synonym)|uniprotkb:PAM(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)	psi-mi:cof1_human(display_long)|uniprotkb:CFL1(gene name)|psi-mi:CFL1(display_short)|uniprotkb:CFL(gene name synonym)|uniprotkb:Cofilin, non-muscle isoform(gene name synonym)|uniprotkb:18 kDa phosphoprotein(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513051|imex:IM-28561-787	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055872.4|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003646(Bacterial SH3-like region)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR012983(PHR)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR038648|mint:O75592|rcsb pdb:5O6C|rcsb pdb:6T7F|ensembl:ENSG00000005810(gene)|ensembl:ENST00000544440(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|dip:DIP-28142N	refseq:NP_005498.1|ensembl:ENSG00000172757(gene)|go:"GO:0031982"(vesicle)|go:"GO:0032587"(ruffle membrane)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0048870"(cell motility)|go:"GO:0051014"(actin filament severing)|go:"GO:0051015"(actin filament binding)|go:"GO:0051293"(establishment of spindle localization)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002108(Actin-binding, cofilin/tropomyosin type)|interpro:IPR017904|interpro:IPR027234|interpro:IPR029006|mint:P23528|rcsb pdb:1Q8G|rcsb pdb:1Q8X|rcsb pdb:3J0S|rcsb pdb:4BEX|rcsb pdb:5HVK|rcsb pdb:5L6W|rcsb pdb:6UBY|rcsb pdb:6UC0|rcsb pdb:6UC4|rcsb pdb:6VAO|reactome:R-HSA-114608|reactome:R-HSA-2029482|reactome:R-HSA-3928662|reactome:R-HSA-399954|reactome:R-HSA-5627117|reactome:R-HSA-8950505|ensembl:ENST00000308162(transcript)|ensembl:ENST00000525451(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0009615"(response to virus)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0030043"(actin filament fragmentation)|go:"GO:0031258"(lamellipodium membrane)|dip:DIP-33000N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:AR3FR/zd48HkVinEfdT17ItGkbU9606	rogid:wgBEUL55sE9G9Be1f/A1OA6KRb49606	rigid:/LxcaNYD+ata/3fydGpALWgBmjw	false	sufficient binding region:2540-3006	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O75592	uniprotkb:P60033	intact:EBI-1043774|uniprotkb:Q5JSX8|uniprotkb:Q5VZN6|uniprotkb:Q6PIB6|uniprotkb:Q9UQ11|uniprotkb:Q9Y6E4|uniprotkb:A6NJC6|ensembl:ENSP00000444596	intact:EBI-712921|ensembl:ENSP00000263645|uniprotkb:P18582|uniprotkb:Q5U0J6	psi-mi:mycb2_human(display_long)|uniprotkb:MYCBP2(gene name)|psi-mi:MYCBP2(display_short)|uniprotkb:KIAA0916(gene name synonym)|uniprotkb:PAM(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)	psi-mi:cd81_human(display_long)|uniprotkb:26 kDa cell surface protein TAPA-1(gene name synonym)|uniprotkb:Target of the antiproliferative antibody 1(gene name synonym)|uniprotkb:Tetraspanin-28(gene name synonym)|uniprotkb:CD81(gene name)|psi-mi:CD81(display_short)|uniprotkb:TAPA1(gene name synonym)|uniprotkb:TSPAN28(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513042|imex:IM-28561-1509	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055872.4|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003646(Bacterial SH3-like region)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR012983(PHR)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR038648|mint:O75592|rcsb pdb:5O6C|rcsb pdb:6T7F|ensembl:ENSG00000005810(gene)|ensembl:ENST00000544440(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|dip:DIP-28142N	ensembl:ENSG00000110651(gene)|ensembl:ENST00000263645(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001772"(immunological synapse)|go:"GO:0002455"(humoral immune response mediated by circulating immunoglobulin)|go:"GO:0002863"(positive regulation of inflammatory response to antigenic stimulus)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008104"(protein localization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0014905"(myoblast fusion involved in skeletal muscle regeneration)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031623"(receptor internalization)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031982"(vesicle)|go:"GO:0034238"(macrophage fusion)|go:"GO:0035783"(CD4-positive, alpha-beta T cell costimulation)|go:"GO:0042289"(MHC class II protein binding)|go:"GO:0043128"(positive regulation of 1-phosphatidylinositol 4-kinase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050861"(positive regulation of B cell receptor signaling pathway)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070863"(positive regulation of protein exit from endoplasmic reticulum)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0072675"(osteoclast fusion)|go:"GO:0097197"(tetraspanin-enriched microdomain)|go:"GO:1903911"(positive regulation of receptor clustering)|go:"GO:1904352"(positive regulation of protein catabolic process in the vacuole)|go:"GO:1905521"(regulation of macrophage migration)|go:"GO:1905676"(positive regulation of adaptive immune memory response)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|go:"GO:2000563"(positive regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2001190"(positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR000301(CD9/CD37/CD63 antigen)|interpro:IPR008952(Tetraspanin)|interpro:IPR018499|interpro:IPR018503|mint:P60033|rcsb pdb:1G8Q|rcsb pdb:1IV5|rcsb pdb:2AVZ|rcsb pdb:3X0E|rcsb pdb:5DFV|rcsb pdb:5DFW|rcsb pdb:5M2C|rcsb pdb:5M33|rcsb pdb:5M3D|rcsb pdb:5M3T|rcsb pdb:5M4R|rcsb pdb:5TCX|rcsb pdb:6EJG|rcsb pdb:6EJM|rcsb pdb:6EK2|rcsb pdb:6U9S|rcsb pdb:7JIC|reactome:R-HSA-198933|reactome:R-HSA-977606|refseq:NP_004347.1|refseq:NP_001284578.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:AR3FR/zd48HkVinEfdT17ItGkbU9606	rogid:LPDYYmkI2TtoCarkcBXuaibfB6A9606	rigid:70dNhPJKcGECxaqz7vrhgznASww	false	sufficient binding region:2540-3006	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O75592	uniprotkb:Q9BRX8	intact:EBI-1043774|uniprotkb:Q5JSX8|uniprotkb:Q5VZN6|uniprotkb:Q6PIB6|uniprotkb:Q9UQ11|uniprotkb:Q9Y6E4|uniprotkb:A6NJC6|ensembl:ENSP00000444596	intact:EBI-4399402|uniprotkb:B2RD81|uniprotkb:Q6UW08|uniprotkb:Q8N2K3|uniprotkb:Q8NBK9|uniprotkb:Q96JR0|ensembl:ENSP00000361254|ensembl:ENSP00000361261|ensembl:ENSP00000361262|ensembl:ENSP00000478152|ensembl:ENSP00000482445	psi-mi:mycb2_human(display_long)|uniprotkb:MYCBP2(gene name)|psi-mi:MYCBP2(display_short)|uniprotkb:KIAA0916(gene name synonym)|uniprotkb:PAM(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)	psi-mi:pxl2a_human(display_long)|uniprotkb:C10orf58(gene name synonym)|uniprotkb:PAMM(gene name synonym)|uniprotkb:Peroxiredoxin-like 2 activated in M-CSF stimulated monocytes(gene name synonym)|uniprotkb:PRXL2A(gene name)|psi-mi:PRXL2A(display_short)|uniprotkb:FAM213A(gene name synonym)|uniprotkb:Redox-regulatory protein FAM213A(gene name synonym)|uniprotkb:PRO2290(orf name)|uniprotkb:PSEC0139(orf name)|uniprotkb:UNQ611/PRO1198(orf name)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513033|imex:IM-28561-1507	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055872.4|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003646(Bacterial SH3-like region)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR012983(PHR)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR038648|mint:O75592|rcsb pdb:5O6C|rcsb pdb:6T7F|ensembl:ENSG00000005810(gene)|ensembl:ENST00000544440(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|dip:DIP-28142N	refseq:NP_115709.3|refseq:NP_001230707.1|refseq:NP_001230708.1|refseq:NP_001230709.1|refseq:NP_001230710.1|refseq:XP_011538567.1|refseq:XP_011538568.1|refseq:NP_001230711.1|ensembl:ENSG00000122378(gene)|ensembl:ENST00000372181(transcript)|ensembl:ENST00000372187(transcript)|ensembl:ENST00000372188(transcript)|ensembl:ENST00000606162(transcript)|ensembl:ENST00000615554(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0016209"(antioxidant activity)|go:"GO:0045670"(regulation of osteoclast differentiation)|interpro:IPR032801|interpro:IPR032802|mint:Q9BRX8	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:AR3FR/zd48HkVinEfdT17ItGkbU9606	rogid:qAvv/5+5HfPHe6kqNCdbmDQvvMw9606	rigid:TU4MGyZUzAOFjC6shfZRmheYKJY	false	sufficient binding region:2540-3006	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O75592	uniprotkb:Q9H765	intact:EBI-1043774|uniprotkb:Q5JSX8|uniprotkb:Q5VZN6|uniprotkb:Q6PIB6|uniprotkb:Q9UQ11|uniprotkb:Q9Y6E4|uniprotkb:A6NJC6|ensembl:ENSP00000444596	intact:EBI-3942509|uniprotkb:Q547Q2|uniprotkb:A8K1P2|ensembl:ENSP00000320893|ensembl:ENSP00000445622	psi-mi:mycb2_human(display_long)|uniprotkb:MYCBP2(gene name)|psi-mi:MYCBP2(display_short)|uniprotkb:KIAA0916(gene name synonym)|uniprotkb:PAM(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)	psi-mi:asb8_human(display_long)|uniprotkb:ASB8(gene name)|psi-mi:ASB8(display_short)|uniprotkb:PP14212(orf name)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513024|imex:IM-28561-355	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055872.4|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003646(Bacterial SH3-like region)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR012983(PHR)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR038648|mint:O75592|rcsb pdb:5O6C|rcsb pdb:6T7F|ensembl:ENSG00000005810(gene)|ensembl:ENST00000544440(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|dip:DIP-28142N	ensembl:ENSG00000177981(gene)|ensembl:ENST00000317697(transcript)|ensembl:ENST00000536549(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0035556"(intracellular signal transduction)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036036|interpro:IPR036770|interpro:IPR037332|mint:Q9H765|reactome:R-HSA-8951664|reactome:R-HSA-983168|refseq:NP_077000.1|refseq:NP_001306225.1|refseq:NP_001306226.1|refseq:NP_001306227.1|refseq:NP_001306228.1|refseq:NP_001306229.1|refseq:NP_001306230.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:AR3FR/zd48HkVinEfdT17ItGkbU9606	rogid:TLjOfkyUnX91j0Lh2kZvf2uBMGI9606	rigid:b5Ik1/RyvEZTcjs3Rh/EAwXWR70	false	sufficient binding region:2540-3006	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O75592	uniprotkb:O75915	intact:EBI-1043774|uniprotkb:Q5JSX8|uniprotkb:Q5VZN6|uniprotkb:Q6PIB6|uniprotkb:Q9UQ11|uniprotkb:Q9Y6E4|uniprotkb:A6NJC6|ensembl:ENSP00000444596	intact:EBI-2860752|uniprotkb:B2R6V5|uniprotkb:Q53ES3|uniprotkb:Q5KU08|ensembl:ENSP00000273258	psi-mi:mycb2_human(display_long)|uniprotkb:MYCBP2(gene name)|psi-mi:MYCBP2(display_short)|uniprotkb:KIAA0916(gene name synonym)|uniprotkb:PAM(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)	psi-mi:praf3_human(display_long)|uniprotkb:ARL6IP5(gene name)|psi-mi:ARL6IP5(display_short)|uniprotkb:DERP11(gene name synonym)|uniprotkb:JWA(gene name synonym)|uniprotkb:PRA2(gene name synonym)|uniprotkb:PRAF3(gene name synonym)|uniprotkb:ADP-ribosylation factor-like protein 6-interacting protein 5(gene name synonym)|uniprotkb:Cytoskeleton-related vitamin A-responsive protein(gene name synonym)|uniprotkb:Dermal papilla-derived protein 11(gene name synonym)|uniprotkb:GTRAP3-18(gene name synonym)|uniprotkb:Glutamate transporter EAAC1-interacting protein(gene name synonym)|uniprotkb:JM5(gene name synonym)|uniprotkb:Prenylated Rab acceptor protein 2(gene name synonym)|uniprotkb:Protein JWa(gene name synonym)|uniprotkb:Putative MAPK-activating protein PM27(gene name synonym)|uniprotkb:HSPC127(orf name)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513015|imex:IM-28561-353	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055872.4|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003646(Bacterial SH3-like region)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR012983(PHR)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR038648|mint:O75592|rcsb pdb:5O6C|rcsb pdb:6T7F|ensembl:ENSG00000005810(gene)|ensembl:ENST00000544440(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|dip:DIP-28142N	refseq:NP_006398.1|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0051051"(negative regulation of transport)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098712"(L-glutamate import across plasma membrane)|interpro:IPR004895(Prenylated rab acceptor PRA1)|mint:O75915|reactome:R-HSA-210500|ensembl:ENSG00000144746(gene)|ensembl:ENST00000273258(transcript)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0007611"(learning or memory)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0010917"(negative regulation of mitochondrial membrane potential)|go:"GO:0015031"(protein transport)|go:"GO:0015813"(L-glutamate transmembrane transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0036475"(neuron death in response to oxidative stress)|go:"GO:0043065"(positive regulation of apoptotic process)	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:AR3FR/zd48HkVinEfdT17ItGkbU9606	rogid:TG2yH1gqzVhFgxBtuZqsE1dLAvQ9606	rigid:MjeXnMN+Z0G4+7BAWRRsdxhy9OE	false	sufficient binding region:2540-3006	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O75592	uniprotkb:Q9NY61	intact:EBI-1043774|uniprotkb:Q5JSX8|uniprotkb:Q5VZN6|uniprotkb:Q6PIB6|uniprotkb:Q9UQ11|uniprotkb:Q9Y6E4|uniprotkb:A6NJC6|ensembl:ENSP00000444596	intact:EBI-372428|uniprotkb:A6NCJ6|uniprotkb:Q9P0A4|uniprotkb:Q9UNX5|uniprotkb:B3KQ26|intact:EBI-28984804|ensembl:ENSP00000477848|ensembl:ENSP00000481894	psi-mi:mycb2_human(display_long)|uniprotkb:MYCBP2(gene name)|psi-mi:MYCBP2(display_short)|uniprotkb:KIAA0916(gene name synonym)|uniprotkb:PAM(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)	psi-mi:aatf_human(display_long)|uniprotkb:Apoptosis-antagonizing transcription factor(gene name synonym)|uniprotkb:Rb-binding protein Che-1(gene name synonym)|uniprotkb:AATF(gene name)|psi-mi:AATF(display_short)|uniprotkb:CHE1(gene name synonym)|uniprotkb:DED(gene name synonym)|uniprotkb:HSPC277(orf name)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513006|imex:IM-28561-1229	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055872.4|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003646(Bacterial SH3-like region)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR012983(PHR)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR038648|mint:O75592|rcsb pdb:5O6C|rcsb pdb:6T7F|ensembl:ENSG00000005810(gene)|ensembl:ENST00000544440(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|dip:DIP-28142N	refseq:NP_036270.1|ensembl:ENSG00000275700(gene)|ensembl:ENSG00000276072(gene)|ensembl:ENST00000619387(transcript)|ensembl:ENST00000620004(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007155"(cell adhesion)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032929"(negative regulation of superoxide anion generation)|go:"GO:0040016"(embryonic cleavage)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043522"(leucine zipper domain binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048156"(tau protein binding)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR012617(TRAUB)|interpro:IPR025160|interpro:IPR039223|mint:Q9NY61|rcsb pdb:5W6A|reactome:R-HSA-193648|ensembl:ENSP00000477848|ensembl:ENSP00000481894	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:AR3FR/zd48HkVinEfdT17ItGkbU9606	rogid:yv0URVqqWKOlJws34IX1T/vBipI9606	rigid:wpjGQ6PMG4PWjGc/WQdMVwP3e8k	false	sufficient binding region:4355-4678	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9UBB5	uniprotkb:Q16637	intact:EBI-923391|uniprotkb:Q9UIS8|uniprotkb:O95242|ensembl:ENSP00000256429	intact:EBI-395421|uniprotkb:Q13119|uniprotkb:Q549U5|uniprotkb:Q96J51|ensembl:ENSP00000305857|uniprotkb:A8K0V4|ensembl:ENSP00000370083|ensembl:ENSP00000370117|ensembl:ENSP00000370119|ensembl:ENSP00000479920|ensembl:ENSP00000482966|ensembl:ENSP00000483515|ensembl:ENSP00000483819|ensembl:ENSP00000487206|ensembl:ENSP00000487421	psi-mi:mbd2_human(display_long)|uniprotkb:MBD2(gene name)|psi-mi:MBD2(display_short)|uniprotkb:Methyl-CpG-binding protein MBD2(gene name synonym)|uniprotkb:Demethylase(gene name synonym)	psi-mi:smn_human(display_long)|uniprotkb:SMN1(gene name)|psi-mi:SMN1(display_short)|uniprotkb:SMN(gene name synonym)|uniprotkb:SMNT(gene name synonym)|uniprotkb:SMN2(gene name)|psi-mi:SMN2(display_short)|uniprotkb:SMNC(gene name synonym)|uniprotkb:Component of gems 1(gene name synonym)|uniprotkb:Gemin-1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512997|imex:IM-28561-1227	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003918.1|refseq:NP_056647.1|ensembl:ENSG00000134046(gene)|ensembl:ENST00000256429(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003696"(satellite DNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006346"(DNA methylation-dependent heterochromatin assembly)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032355"(response to estradiol)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034622"|go:"GO:0035197"(siRNA binding)|go:"GO:0035563"(positive regulation of chromatin binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042711"(maternal behavior)|go:"GO:0043044"|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048568"(embryonic organ development)|go:"GO:0070742"(C2H2 zinc finger domain binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR016177(DNA-binding, integrase-type)|interpro:IPR025884|interpro:IPR032343|mint:Q9UBB5|rcsb pdb:2L2L|rcsb pdb:6C1A|rcsb pdb:6C1T|rcsb pdb:6C1U|rcsb pdb:6C1V|rcsb pdb:6C2F|rcsb pdb:6CNP|rcsb pdb:6CNQ|rcsb pdb:7AO8|rcsb pdb:7AO9|rcsb pdb:7AOA|reactome:R-HSA-427413|reactome:R-HSA-73728	refseq:NP_000335.1|refseq:NP_059107.1|refseq:NP_075012.1|refseq:NP_075013.1|refseq:NP_075014.1|refseq:NP_075015.1|ensembl:ENSG00000172062(gene)|ensembl:ENSG00000205571(gene)|ensembl:ENSG00000273772(gene)|ensembl:ENSG00000275349(gene)|ensembl:ENSG00000277773(gene)|ensembl:ENST00000351205(transcript)|ensembl:ENST00000380707(transcript)|ensembl:ENST00000380741(transcript)|ensembl:ENST00000380743(transcript)|ensembl:ENST00000614610(transcript)|ensembl:ENST00000618251(transcript)|ensembl:ENST00000618661(transcript)|ensembl:ENST00000622739(transcript)|ensembl:ENST00000627341(transcript)|ensembl:ENST00000629122(transcript)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006353"(DNA-templated transcription, termination)|go:"GO:0007399"(nervous system development)|go:"GO:0015030"(Cajal body)|go:"GO:0016604"(nuclear body)|go:"GO:0030018"(Z disc)|go:"GO:0030424"(axon)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0097504"(Gemini of coiled bodies)|interpro:IPR002999(Tudor)|interpro:IPR010304(Survival motor neuron)|mint:Q16637|rcsb pdb:1G5V|rcsb pdb:1MHN|rcsb pdb:2LEH|rcsb pdb:4A4E|rcsb pdb:4A4G|rcsb pdb:4GLI|rcsb pdb:4QQ6|rcsb pdb:5XJL|go:"GO:0034719"(SMN-Sm protein complex)|rcsb pdb:5XJQ|rcsb pdb:5XJR|rcsb pdb:5XJS|rcsb pdb:5XJT|rcsb pdb:5XJU|reactome:R-HSA-191859|go:"GO:0032797"(SMN complex)|refseq:NP_001284644.1|ensembl:ENSP00000305857|ensembl:ENSP00000370083|ensembl:ENSP00000370117|ensembl:ENST00000380742|ensembl:ENSP00000370118|ensembl:ENSP00000370119|ensembl:ENST00000503079|ensembl:ENSP00000428128|ensembl:ENST00000506163|ensembl:ENSP00000424926|ensembl:ENST00000611442|ensembl:ENSP00000483768|ensembl:ENST00000614240|ensembl:ENSP00000479279|ensembl:ENSP00000479920|ensembl:ENST00000614773|ensembl:ENSP00000481427|ensembl:ENSP00000483515|ensembl:ENSP00000483819|ensembl:ENST00000622158|ensembl:ENSP00000480906|ensembl:ENSP00000482966|ensembl:ENST00000624634|ensembl:ENSP00000485595|ensembl:ENST00000626847|ensembl:ENSP00000486152|ensembl:ENSP00000487421|ensembl:ENST00000628353|ensembl:ENSP00000487029|ensembl:ENST00000628642|ensembl:ENSP00000487015|ensembl:ENSP00000487206|refseq:XP_016865275.1|dip:DIP-31309N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:8DO+M6oIpbSfTFPVLADdXaaqzEU9606	rogid:QGivm7E8suciCWXO4l0zCUzCl2g9606	rigid:04GsmAV8xbkumHu55Ptl32niTb8	false	sufficient binding region:12-145	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9UBB5	uniprotkb:Q86SE5	intact:EBI-923391|uniprotkb:Q9UIS8|uniprotkb:O95242|ensembl:ENSP00000256429	intact:EBI-741520|uniprotkb:Q6ZW87|uniprotkb:Q8N1C2|uniprotkb:B3KTH2|ensembl:ENSP00000428667|ensembl:ENSP00000430367|ensembl:ENSP00000430394|uniprotkb:G3V129	psi-mi:mbd2_human(display_long)|uniprotkb:MBD2(gene name)|psi-mi:MBD2(display_short)|uniprotkb:Methyl-CpG-binding protein MBD2(gene name synonym)|uniprotkb:Demethylase(gene name synonym)	psi-mi:ralyl_human(display_long)|uniprotkb:Heterogeneous nuclear ribonucleoprotein C-like 3(gene name synonym)|uniprotkb:RALYL(gene name)|psi-mi:RALYL(display_short)|uniprotkb:HNRPCL3(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512990|imex:IM-28561-1557	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003918.1|refseq:NP_056647.1|ensembl:ENSG00000134046(gene)|ensembl:ENST00000256429(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003696"(satellite DNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006346"(DNA methylation-dependent heterochromatin assembly)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032355"(response to estradiol)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034622"|go:"GO:0035197"(siRNA binding)|go:"GO:0035563"(positive regulation of chromatin binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042711"(maternal behavior)|go:"GO:0043044"|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048568"(embryonic organ development)|go:"GO:0070742"(C2H2 zinc finger domain binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR016177(DNA-binding, integrase-type)|interpro:IPR025884|interpro:IPR032343|mint:Q9UBB5|rcsb pdb:2L2L|rcsb pdb:6C1A|rcsb pdb:6C1T|rcsb pdb:6C1U|rcsb pdb:6C1V|rcsb pdb:6C2F|rcsb pdb:6CNP|rcsb pdb:6CNQ|rcsb pdb:7AO8|rcsb pdb:7AO9|rcsb pdb:7AOA|reactome:R-HSA-427413|reactome:R-HSA-73728	refseq:NP_001093861.1|refseq:NP_001093862.1|refseq:NP_001093863.1|refseq:NP_776247.3|ensembl:ENSG00000184672(gene)|ensembl:ENST00000521268(transcript)|ensembl:ENST00000521695(transcript)|ensembl:ENST00000522455(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0042802"(identical protein binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR017347(Heterogeneous nuclear ribonucleoprotein C, Raly)|interpro:IPR034504|interpro:IPR035979|mint:Q86SE5|refseq:NP_001274173.1|refseq:XP_016868548.1|refseq:XP_016868549.1|refseq:XP_016868550.1|refseq:XP_016868551.1|refseq:XP_016868552.1|refseq:XP_016868553.1|refseq:XP_016868554.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:8DO+M6oIpbSfTFPVLADdXaaqzEU9606	rogid:/dJc0rSACk93SMMAkFSfi2YdWuo9606	rigid:7+5vW7bJKu3XsH+TGwbe+0r3OW8	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9UBB5	uniprotkb:Q99873	intact:EBI-923391|uniprotkb:Q9UIS8|uniprotkb:O95242|ensembl:ENSP00000256429	intact:EBI-78738|intact:EBI-949313|uniprotkb:A0A087X1W2|uniprotkb:H7C2I1|uniprotkb:Q15529|uniprotkb:Q99872|uniprotkb:Q99874|uniprotkb:Q9NZ04|uniprotkb:Q9NZ05|uniprotkb:Q9NZ06|ensembl:ENSP00000406162|intact:EBI-2622582|uniprotkb:B4E3C3|uniprotkb:G5E9B6|uniprotkb:Q8WUW5|uniprotkb:Q2VP93|uniprotkb:Q6LEU5|intact:EBI-11034520|intact:EBI-6137914	psi-mi:mbd2_human(display_long)|uniprotkb:MBD2(gene name)|psi-mi:MBD2(display_short)|uniprotkb:Methyl-CpG-binding protein MBD2(gene name synonym)|uniprotkb:Demethylase(gene name synonym)	psi-mi:anm1_human(display_long)|uniprotkb:PRMT1(gene name)|psi-mi:PRMT1(display_short)|uniprotkb:Interferon receptor 1-bound protein 4(gene name synonym)|uniprotkb:Histone-arginine N-methyltransferase PRMT1(gene name synonym)|uniprotkb:HMT2(gene name synonym)|uniprotkb:HRMT1L2(gene name synonym)|uniprotkb:IR1B4(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512981|imex:IM-28561-1071	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003918.1|refseq:NP_056647.1|ensembl:ENSG00000134046(gene)|ensembl:ENST00000256429(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003696"(satellite DNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006346"(DNA methylation-dependent heterochromatin assembly)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032355"(response to estradiol)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034622"|go:"GO:0035197"(siRNA binding)|go:"GO:0035563"(positive regulation of chromatin binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042711"(maternal behavior)|go:"GO:0043044"|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048568"(embryonic organ development)|go:"GO:0070742"(C2H2 zinc finger domain binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR016177(DNA-binding, integrase-type)|interpro:IPR025884|interpro:IPR032343|mint:Q9UBB5|rcsb pdb:2L2L|rcsb pdb:6C1A|rcsb pdb:6C1T|rcsb pdb:6C1U|rcsb pdb:6C1V|rcsb pdb:6C2F|rcsb pdb:6CNP|rcsb pdb:6CNQ|rcsb pdb:7AO8|rcsb pdb:7AO9|rcsb pdb:7AOA|reactome:R-HSA-427413|reactome:R-HSA-73728	ensembl:ENSG00000126457(gene)|ensembl:ENST00000454376(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006479"(protein methylation)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0008170"(N-methyltransferase activity)|go:"GO:0008276"(protein methyltransferase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0016274"(protein-arginine N-methyltransferase activity)|go:"GO:0016571"(histone methylation)|go:"GO:0018216"(peptidyl-arginine methylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0034709"(methylosome)|go:"GO:0035241"(protein-arginine omega-N monomethyltransferase activity)|go:"GO:0035242"(protein-arginine omega-N asymmetric methyltransferase activity)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043985"(histone H4-R3 methylation)|go:"GO:0044020"("histone methyltransferase activity (H4-R3 specific)")|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045652"(regulation of megakaryocyte differentiation)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0046985"(positive regulation of hemoglobin biosynthetic process)|go:"GO:0048273"(mitogen-activated protein kinase p38 binding)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0051260"(protein homooligomerization)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1904047"(S-adenosyl-L-methionine binding)|interpro:IPR025799|interpro:IPR029063|interpro:IPR041698|mint:Q99873|rcsb pdb:6NT2|reactome:R-HSA-3214858|reactome:R-HSA-6804114|reactome:R-HSA-8936459|reactome:R-HSA-9009391|reactome:R-HSA-9018519|refseq:NP_001527.3|refseq:NP_938074.2|refseq:XP_016882223.1|refseq:XP_016882224.1|refseq:NP_001193971.1|dip:DIP-30878N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:8DO+M6oIpbSfTFPVLADdXaaqzEU9606	rogid:8I7isKQC9YJTBzPz1Qve4V8l8Xg9606	rigid:3bSOGD7jPR9HVU6WRlechJFXnn0	false	sufficient binding region:12-145	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9UBB5	uniprotkb:Q07021	intact:EBI-923391|uniprotkb:Q9UIS8|uniprotkb:O95242|ensembl:ENSP00000256429	intact:EBI-347528|uniprotkb:Q2HXR8|uniprotkb:Q9NNY8|intact:EBI-15990352|ensembl:ENSP00000225698	psi-mi:mbd2_human(display_long)|uniprotkb:MBD2(gene name)|psi-mi:MBD2(display_short)|uniprotkb:Methyl-CpG-binding protein MBD2(gene name synonym)|uniprotkb:Demethylase(gene name synonym)	psi-mi:c1qbp_human(display_long)|uniprotkb:C1QBP(gene name)|psi-mi:C1QBP(display_short)|uniprotkb:GC1QBP(gene name synonym)|uniprotkb:HABP1(gene name synonym)|uniprotkb:SF2P32(gene name synonym)|uniprotkb:Glycoprotein gC1qBP(gene name synonym)|uniprotkb:Hyaluronan-binding protein 1(gene name synonym)|uniprotkb:Mitochondrial matrix protein p32(gene name synonym)|uniprotkb:p33(gene name synonym)|uniprotkb:ASF/SF2-associated protein p32(gene name synonym)|uniprotkb:gC1q-R protein(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512972|imex:IM-28561-1783	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003918.1|refseq:NP_056647.1|ensembl:ENSG00000134046(gene)|ensembl:ENST00000256429(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003696"(satellite DNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006346"(DNA methylation-dependent heterochromatin assembly)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032355"(response to estradiol)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034622"|go:"GO:0035197"(siRNA binding)|go:"GO:0035563"(positive regulation of chromatin binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042711"(maternal behavior)|go:"GO:0043044"|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048568"(embryonic organ development)|go:"GO:0070742"(C2H2 zinc finger domain binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR016177(DNA-binding, integrase-type)|interpro:IPR025884|interpro:IPR032343|mint:Q9UBB5|rcsb pdb:2L2L|rcsb pdb:6C1A|rcsb pdb:6C1T|rcsb pdb:6C1U|rcsb pdb:6C1V|rcsb pdb:6C2F|rcsb pdb:6CNP|rcsb pdb:6CNQ|rcsb pdb:7AO8|rcsb pdb:7AO9|rcsb pdb:7AOA|reactome:R-HSA-427413|reactome:R-HSA-73728	refseq:NP_001203.1|dip:DIP-31164N|ensembl:ENSG00000108561(gene)|ensembl:ENST00000225698(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005540"(hyaluronic acid binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006397"(mRNA processing)|go:"GO:0006915"(apoptotic process)|go:"GO:0006955"(immune response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0008494"(translation activator activity)|go:"GO:0009986"(cell surface)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0030449"(regulation of complement activation)|go:"GO:0030984"(kininogen binding)|go:"GO:0031690"(adrenergic receptor binding)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0039534"(negative regulation of MDA-5 signaling pathway)|go:"GO:0039536"(negative regulation of RIG-I signaling pathway)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0042256"(mature ribosome assembly)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050687"(negative regulation of defense response to virus)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070131"(positive regulation of mitochondrial translation)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0097177"(mitochondrial ribosome binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:2000510"(positive regulation of dendritic cell chemotaxis)|interpro:IPR003428(Mitochondrial glycoprotein)|interpro:IPR036561|mint:Q07021|rcsb pdb:1P32|rcsb pdb:3RPX|rcsb pdb:6SZW|reactome:R-HSA-111471|go:"GO:0005886"(plasma membrane)|reactome:R-HSA-8980692|reactome:R-HSA-9013106|reactome:R-HSA-9645722|reactome:R-HSA-140837	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:8DO+M6oIpbSfTFPVLADdXaaqzEU9606	rogid:NfZ31HjbYZxd8UQKRXczhpc306E9606	rigid:402kE9NNBFgcafrkF5hmmGKboqM	false	sufficient binding region:12-145	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9UBB5	uniprotkb:Q8N7W2	intact:EBI-923391|uniprotkb:Q9UIS8|uniprotkb:O95242|ensembl:ENSP00000256429	intact:EBI-743382|uniprotkb:Q5SYY7|uniprotkb:Q5SYY8|uniprotkb:Q5SYY9|uniprotkb:Q8N5T7	psi-mi:mbd2_human(display_long)|uniprotkb:MBD2(gene name)|psi-mi:MBD2(display_short)|uniprotkb:Methyl-CpG-binding protein MBD2(gene name synonym)|uniprotkb:Demethylase(gene name synonym)	psi-mi:bend7_human(display_long)|uniprotkb:BEND7(gene name)|psi-mi:BEND7(display_short)|uniprotkb:C10orf30(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512965|imex:IM-28561-419	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003918.1|refseq:NP_056647.1|ensembl:ENSG00000134046(gene)|ensembl:ENST00000256429(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003696"(satellite DNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006346"(DNA methylation-dependent heterochromatin assembly)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032355"(response to estradiol)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034622"|go:"GO:0035197"(siRNA binding)|go:"GO:0035563"(positive regulation of chromatin binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042711"(maternal behavior)|go:"GO:0043044"|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048568"(embryonic organ development)|go:"GO:0070742"(C2H2 zinc finger domain binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR016177(DNA-binding, integrase-type)|interpro:IPR025884|interpro:IPR032343|mint:Q9UBB5|rcsb pdb:2L2L|rcsb pdb:6C1A|rcsb pdb:6C1T|rcsb pdb:6C1U|rcsb pdb:6C1V|rcsb pdb:6C2F|rcsb pdb:6CNP|rcsb pdb:6CNQ|rcsb pdb:7AO8|rcsb pdb:7AO9|rcsb pdb:7AOA|reactome:R-HSA-427413|reactome:R-HSA-73728	go:"GO:0070062"(extracellular exosome)|refseq:NP_001094382.1|refseq:NP_689964.2|interpro:IPR018379|refseq:XP_011517694.1|refseq:XP_011517713.1|mint:Q8N7W2	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:8DO+M6oIpbSfTFPVLADdXaaqzEU9606	rogid:mI/DE8ufhQLhjvmytV1m4g24Yqk9606	rigid:G56wOPJ+JwB8rCJnF5NcrgWnvE8	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9UIS9	uniprotkb:Q8TF68	intact:EBI-867196|uniprotkb:K7ELI2|uniprotkb:Q9UNZ9|uniprotkb:K7EQZ4|uniprotkb:K7ESN0|uniprotkb:A4UTZ0|uniprotkb:O15248|uniprotkb:O95241|uniprotkb:Q7Z7B5|uniprotkb:Q8N4W4|uniprotkb:Q9UNZ6|uniprotkb:Q9UNZ7|uniprotkb:Q9UNZ8|uniprotkb:B4DXJ5|uniprotkb:E9PEC5|intact:EBI-10977266|ensembl:ENSP00000269468|ensembl:ENSP00000372407|ensembl:ENSP00000467017	intact:EBI-6115971|uniprotkb:O15407|uniprotkb:Q7Z722|uniprotkb:Q8N938|ensembl:ENSP00000354592|ensembl:ENSP00000380019	psi-mi:mbd1_human(display_long)|uniprotkb:CXXC3(gene name synonym)|uniprotkb:Methyl-CpG-binding protein MBD1(gene name synonym)|uniprotkb:Protein containing methyl-CpG-binding domain 1(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 3(gene name synonym)|uniprotkb:MBD1(gene name)|psi-mi:MBD1(display_short)|uniprotkb:PCM1(gene name synonym)	psi-mi:zn384_human(display_long)|uniprotkb:ZNF384(gene name)|psi-mi:ZNF384(display_short)|uniprotkb:CAGH1(gene name synonym)|uniprotkb:CIZ(gene name synonym)|uniprotkb:NMP4(gene name synonym)|uniprotkb:TNRC1(gene name synonym)|uniprotkb:CAG repeat protein 1(gene name synonym)|uniprotkb:CAS-interacting zinc finger protein(gene name synonym)|uniprotkb:Nuclear matrix transcription factor 4(gene name synonym)|uniprotkb:Trinucleotide repeat-containing gene 1 protein(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26512956|imex:IM-28561-417	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001191065.1|refseq:NP_001191068.1|refseq:NP_001191071.1|refseq:NP_001191072.1|refseq:NP_001191080.1|refseq:NP_002375.1|refseq:NP_056669.2|refseq:NP_056670.2|refseq:NP_056671.2|refseq:NP_056723.2|refseq:XP_011524295.1|refseq:XP_016881249.1|refseq:XP_016881259.1|refseq:XP_016881260.1|refseq:XP_016881265.1|refseq:XP_011524296.1|refseq:XP_011524308.1|refseq:NP_001191066.1|refseq:NP_001191067.1|refseq:NP_001191069.1|refseq:NP_001191070.1|refseq:XP_005258328.1|ensembl:ENSG00000141644(gene)|ensembl:ENST00000269468(transcript)|ensembl:ENST00000382948(transcript)|ensembl:ENST00000591416(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0010385"(double-stranded methylated DNA binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032355"(response to estradiol)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR016177(DNA-binding, integrase-type)|mint:Q9UIS9|rcsb pdb:1D9N|rcsb pdb:1IG4|rcsb pdb:4D4W|rcsb pdb:5W9Q|rcsb pdb:6D1T|reactome:R-HSA-3899300	ensembl:ENST00000319770|ensembl:ENSP00000321650|ensembl:ENSP00000354592|ensembl:ENSP00000380019|ensembl:ENST00000355772|ensembl:ENSP00000348018|refseq:NP_001035009.1|refseq:NP_001129206.1|refseq:NP_597733.2|refseq:XP_016874430.1|refseq:XP_016874431.1|refseq:XP_016874432.1|refseq:XP_016874438.1|refseq:XP_016874439.1|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:Q8TF68|ensembl:ENSG00000126746(gene)|ensembl:ENST00000361959(transcript)|ensembl:ENST00000396801(transcript)	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:I6StIYNuO8jT6ZR1YxoZnzDrP/I9606	rogid:6TO45205H9niXg8StUmIooVLC289606	rigid:d+5iD0ngVNFymDrk6khvK8foqOk	false	sufficient binding region:80-340	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O75592	uniprotkb:P08238	intact:EBI-1043774|uniprotkb:Q5JSX8|uniprotkb:Q5VZN6|uniprotkb:Q6PIB6|uniprotkb:Q9UQ11|uniprotkb:Q9Y6E4|uniprotkb:A6NJC6|ensembl:ENSP00000444596	intact:EBI-352572|ensembl:ENSP00000325875|ensembl:ENSP00000360609|ensembl:ENSP00000360709|ensembl:ENSP00000481908|uniprotkb:Q5T9W7|uniprotkb:Q9NQW0|uniprotkb:Q9NTK6|uniprotkb:B2R5P0	psi-mi:mycb2_human(display_long)|uniprotkb:MYCBP2(gene name)|psi-mi:MYCBP2(display_short)|uniprotkb:KIAA0916(gene name synonym)|uniprotkb:PAM(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)	psi-mi:hs90b_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short)|uniprotkb:HSP90B(gene name synonym)|uniprotkb:HSPC2(gene name synonym)|uniprotkb:HSPCB(gene name synonym)|uniprotkb:Heat shock 84 kDa(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513096|imex:IM-28561-1231	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055872.4|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003646(Bacterial SH3-like region)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR012983(PHR)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR038648|mint:O75592|rcsb pdb:5O6C|rcsb pdb:6T7F|ensembl:ENSG00000005810(gene)|ensembl:ENST00000544440(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|dip:DIP-28142N	ensembl:ENSG00000096384(gene)|ensembl:ENST00000353801(transcript)|ensembl:ENST00000371554(transcript)|ensembl:ENST00000371646(transcript)|ensembl:ENST00000620073(transcript)|go:"GO:0001890"(placenta development)|go:"GO:0002134"(UTP binding)|go:"GO:0002135"(CTP binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|refseq:NP_031381.2|go:"GO:0005739"(mitochondrion)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009651"(response to salt stress)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017098"(sulfonylurea receptor binding)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031526"(brush border membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032564"(dATP binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042220"(response to cocaine)|go:"GO:0042277"(peptide binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042470"(melanosome)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0120293"(dynein axonemal particle)|go:"GO:1901389"(negative regulation of transforming growth factor beta activation)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903660"(negative regulation of complement-dependent cytotoxicity)|go:"GO:1903827"|go:"GO:1904031"(positive regulation of cyclin-dependent protein kinase activity)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|go:"GO:1990913"(sperm head plasma membrane)|go:"GO:1990917"(ooplasm)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P08238|rcsb pdb:1QZ2|rcsb pdb:1UYM|rcsb pdb:2L6J|rcsb pdb:3FWV|rcsb pdb:3NMQ|rcsb pdb:3PRY|rcsb pdb:3UQ3|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5UC4|rcsb pdb:5UCH|rcsb pdb:5UCI|rcsb pdb:5UCJ|rcsb pdb:6N8W|rcsb pdb:6N8Y|reactome:R-HSA-168928|reactome:R-HSA-2029482|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-399954|reactome:R-HSA-5336415|reactome:R-HSA-6798695|reactome:R-HSA-844456|reactome:R-HSA-8852276|reactome:R-HSA-8937144|reactome:R-HSA-8939211|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9660826|reactome:R-HSA-9679191|refseq:NP_001258898.1|refseq:NP_001258899.1|refseq:NP_001258900.1|dip:DIP-413N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:AR3FR/zd48HkVinEfdT17ItGkbU9606	rogid:wOsW7C10v2oMsM+REE38K6PAan09606	rigid:1pk5j4H6xcCRYoV/OR/Z1zSSJ6g	false	sufficient binding region:2540-3006	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O75592	uniprotkb:Q8NCJ5	intact:EBI-1043774|uniprotkb:Q5JSX8|uniprotkb:Q5VZN6|uniprotkb:Q6PIB6|uniprotkb:Q9UQ11|uniprotkb:Q9Y6E4|uniprotkb:A6NJC6|ensembl:ENSP00000444596	intact:EBI-2511300|ensembl:ENSP00000301463|uniprotkb:Q96SK5|uniprotkb:B9EG99	psi-mi:mycb2_human(display_long)|uniprotkb:MYCBP2(gene name)|psi-mi:MYCBP2(display_short)|uniprotkb:KIAA0916(gene name synonym)|uniprotkb:PAM(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)	psi-mi:spry3_human(display_long)|uniprotkb:SPRYD3(gene name)|psi-mi:SPRYD3(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513227|imex:IM-28561-1715	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055872.4|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003646(Bacterial SH3-like region)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR012983(PHR)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR038648|mint:O75592|rcsb pdb:5O6C|rcsb pdb:6T7F|ensembl:ENSG00000005810(gene)|ensembl:ENST00000544440(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|dip:DIP-28142N	ensembl:ENSG00000167778(gene)|ensembl:ENST00000301463(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007166"(cell surface receptor signaling pathway)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR035783|interpro:IPR043136|mint:Q8NCJ5|rcsb pdb:2YYO|refseq:NP_116229.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:AR3FR/zd48HkVinEfdT17ItGkbU9606	rogid:VbqJ033T2QVGIuwYdCf+WHIiaJ89606	rigid:pygB0txCJF8rZigZhIA3WBt2nbU	false	sufficient binding region:2540-3006	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O75592	uniprotkb:Q6ZT07	intact:EBI-1043774|uniprotkb:Q5JSX8|uniprotkb:Q5VZN6|uniprotkb:Q6PIB6|uniprotkb:Q9UQ11|uniprotkb:Q9Y6E4|uniprotkb:A6NJC6|ensembl:ENSP00000444596	intact:EBI-11047719|uniprotkb:O94958|uniprotkb:D3DNZ1|uniprotkb:A6H8U8|ensembl:ENSP00000411197	psi-mi:mycb2_human(display_long)|uniprotkb:MYCBP2(gene name)|psi-mi:MYCBP2(display_short)|uniprotkb:KIAA0916(gene name synonym)|uniprotkb:PAM(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)	psi-mi:tbcd9_human(display_long)|uniprotkb:TBC1D9(gene name)|psi-mi:TBC1D9(display_short)|uniprotkb:KIAA0882(gene name synonym)|uniprotkb:TBC1 domain family member 9A(gene name synonym)|uniprotkb:TBC1D9A(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513236|imex:IM-28561-147	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055872.4|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003646(Bacterial SH3-like region)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR012983(PHR)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR038648|mint:O75592|rcsb pdb:5O6C|rcsb pdb:6T7F|ensembl:ENSG00000005810(gene)|ensembl:ENST00000544440(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|dip:DIP-28142N	refseq:NP_055945.2|ensembl:ENSG00000109436(gene)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR000195(RabGAP/TBC)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR004182(GRAM)|interpro:IPR011992(EF-Hand type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035969|interpro:IPR036014|interpro:IPR036017|mint:Q6ZT07|ensembl:ENST00000442267(transcript)	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:AR3FR/zd48HkVinEfdT17ItGkbU9606	rogid:l6ZnJq5BB6+qHJ+PkAo6YzrkzVs9606	rigid:GX4bn659AYlMgpWghO+u6A5YDWU	false	sufficient binding region:2540-3006	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O75592	uniprotkb:P00441	intact:EBI-1043774|uniprotkb:Q5JSX8|uniprotkb:Q5VZN6|uniprotkb:Q6PIB6|uniprotkb:Q9UQ11|uniprotkb:Q9Y6E4|uniprotkb:A6NJC6|ensembl:ENSP00000444596	intact:EBI-990792|uniprotkb:A6NHJ0|uniprotkb:Q16669|uniprotkb:Q16711|uniprotkb:Q16838|uniprotkb:Q16839|uniprotkb:Q16840|uniprotkb:Q6NR85|ensembl:ENSP00000270142|uniprotkb:D3DSE4	psi-mi:mycb2_human(display_long)|uniprotkb:MYCBP2(gene name)|psi-mi:MYCBP2(display_short)|uniprotkb:KIAA0916(gene name synonym)|uniprotkb:PAM(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)	psi-mi:sodc_human(display_long)|uniprotkb:Superoxide dismutase 1(gene name synonym)|uniprotkb:SOD1(gene name)|psi-mi:SOD1(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513209|imex:IM-28561-795	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055872.4|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003646(Bacterial SH3-like region)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR012983(PHR)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR038648|mint:O75592|rcsb pdb:5O6C|rcsb pdb:6T7F|ensembl:ENSG00000005810(gene)|ensembl:ENST00000544440(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|dip:DIP-28142N	ensembl:ENSG00000142168(gene)|ensembl:ENST00000270142(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000303"(response to superoxide)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001890"(placenta development)|go:"GO:0001895"(retina homeostasis)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0004784"(superoxide dismutase activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005829"(cytosol)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007566"(embryo implantation)|go:"GO:0007569"(cell aging)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0001975"(response to amphetamine)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0032287"(peripheral nervous system myelin maintenance)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033081"(regulation of T cell differentiation in thymus)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042554"(superoxide anion generation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045541"(negative regulation of cholesterol biosynthetic process)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046620"(regulation of organ growth)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009408"(response to heat)|go:"GO:0010033"(response to organic substance)|go:"GO:0019226"(transmission of nerve impulse)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0030346"(protein phosphatase 2B binding)|go:"GO:0031045"(dense core granule)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031667"(response to nutrient levels)|interpro:IPR024134|interpro:IPR036423|mint:P00441|rcsb pdb:1AZV|rcsb pdb:1BA9|rcsb pdb:1DSW|rcsb pdb:1FUN|rcsb pdb:1HL4|rcsb pdb:1HL5|rcsb pdb:1KMG|rcsb pdb:1L3N|rcsb pdb:1MFM|rcsb pdb:1N18|rcsb pdb:1N19|interpro:IPR018152|rcsb pdb:1OEZ|rcsb pdb:1OZT|rcsb pdb:1OZU|rcsb pdb:1P1V|rcsb pdb:1PTZ|rcsb pdb:1PU0|rcsb pdb:1RK7|rcsb pdb:1SOS|rcsb pdb:1SPD|rcsb pdb:1UXL|rcsb pdb:1UXM|rcsb pdb:2AF2|rcsb pdb:2C9S|rcsb pdb:2C9U|rcsb pdb:2C9V|rcsb pdb:2GBT|rcsb pdb:2GBU|rcsb pdb:2GBV|rcsb pdb:2LU5|rcsb pdb:2MP3|rcsb pdb:2NAM|rcsb pdb:2NNX|rcsb pdb:2R27|rcsb pdb:2V0A|rcsb pdb:2VR6|rcsb pdb:2VR7|rcsb pdb:2VR8|rcsb pdb:2WKO|rcsb pdb:2WYT|rcsb pdb:2WYZ|rcsb pdb:2WZ0|rcsb pdb:2WZ5|rcsb pdb:2WZ6|rcsb pdb:2XJK|rcsb pdb:2XJL|rcsb pdb:2ZKW|rcsb pdb:2ZKX|rcsb pdb:2ZKY|rcsb pdb:3CQP|rcsb pdb:3CQQ|rcsb pdb:3ECU|rcsb pdb:3ECV|rcsb pdb:3ECW|rcsb pdb:3GQF|rcsb pdb:3GTV|rcsb pdb:3GZO|rcsb pdb:3GZP|rcsb pdb:3GZQ|rcsb pdb:3H2P|rcsb pdb:3H2Q|rcsb pdb:3HFF|rcsb pdb:3K91|rcsb pdb:3KH3|rcsb pdb:3KH4|rcsb pdb:3LTV|rcsb pdb:3QQD|rcsb pdb:3RE0|rcsb pdb:3T5W|rcsb pdb:4A7G|rcsb pdb:4A7Q|rcsb pdb:4A7S|rcsb pdb:4A7T|rcsb pdb:4A7U|rcsb pdb:4A7V|rcsb pdb:4B3E|rcsb pdb:4BCY|rcsb pdb:4BCZ|rcsb pdb:4BD4|rcsb pdb:4FF9|rcsb pdb:4MCM|rcsb pdb:4MCN|rcsb pdb:4NIN|rcsb pdb:4NIO|rcsb pdb:4NIP|rcsb pdb:4OH2|rcsb pdb:4SOD|rcsb pdb:4XCR|rcsb pdb:5DLI|rcsb pdb:5IIW|rcsb pdb:5J07|rcsb pdb:5J0C|rcsb pdb:5J0F|rcsb pdb:5J0G|rcsb pdb:5K02|rcsb pdb:5O3Y|rcsb pdb:5O40|rcsb pdb:5U9M|rcsb pdb:5WOR|rcsb pdb:5YTO|rcsb pdb:5YTU|rcsb pdb:5YUL|rcsb pdb:6A9O|rcsb pdb:6B79|rcsb pdb:6DTK|rcsb pdb:6FFK|rcsb pdb:6FLH|rcsb pdb:6FOI|rcsb pdb:6FOL|rcsb pdb:6FON|rcsb pdb:6FP6|rcsb pdb:6SPA|rcsb pdb:6SPH|rcsb pdb:6SPI|rcsb pdb:6SPJ|rcsb pdb:6SPK|rcsb pdb:6Z3V|rcsb pdb:6Z4G|rcsb pdb:6Z4H|rcsb pdb:6Z4I|rcsb pdb:6Z4J|rcsb pdb:6Z4K|rcsb pdb:6Z4L|rcsb pdb:6Z4M|rcsb pdb:6Z4O|reactome:R-HSA-114608|reactome:R-HSA-3299685|reactome:R-HSA-8950505|rcsb pdb:5WMJ|go:"GO:0046688"(response to copper ion)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048538"(thymus development)|go:"GO:0048678"(response to axon injury)|go:"GO:0050665"(hydrogen peroxide biosynthetic process)|go:"GO:0046677"(response to antibiotic)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0051087"(chaperone binding)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0060047"(heart contraction)|go:"GO:0060052"(neurofilament cytoskeleton organization)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0060088"(auditory receptor cell stereocilium organization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071318"(cellular response to ATP)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0097332"(response to antipsychotic drug)|go:"GO:1902177"(positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR001424(Superoxide dismutase, copper/zinc binding)|refseq:NP_000445.1|dip:DIP-44941N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:AR3FR/zd48HkVinEfdT17ItGkbU9606	rogid:W5O3CdnrxKm1kudXW04wxnCxTY09606	rigid:w/I7yWL2WH956tfQcqDVfoqGJnA	false	sufficient binding region:2540-3006	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O75592	uniprotkb:P35237	intact:EBI-1043774|uniprotkb:Q5JSX8|uniprotkb:Q5VZN6|uniprotkb:Q6PIB6|uniprotkb:Q9UQ11|uniprotkb:Q9Y6E4|uniprotkb:A6NJC6|ensembl:ENSP00000444596	intact:EBI-2554816|uniprotkb:B2RBA8|uniprotkb:Q59F97|uniprotkb:Q7Z2Y7|uniprotkb:Q9UDI7|uniprotkb:Q5TD06|uniprotkb:Q96J44|ensembl:ENSP00000369891|ensembl:ENSP00000369896|ensembl:ENSP00000369901|ensembl:ENSP00000369912|ensembl:ENSP00000369919|ensembl:ENSP00000493936|ensembl:ENSP00000494650|ensembl:ENSP00000496073	psi-mi:mycb2_human(display_long)|uniprotkb:MYCBP2(gene name)|psi-mi:MYCBP2(display_short)|uniprotkb:KIAA0916(gene name synonym)|uniprotkb:PAM(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)	psi-mi:spb6_human(display_long)|uniprotkb:PI6(gene name synonym)|uniprotkb:PTI(gene name synonym)|uniprotkb:Placental thrombin inhibitor(gene name synonym)|uniprotkb:Cytoplasmic antiproteinase(gene name synonym)|uniprotkb:Peptidase inhibitor 6(gene name synonym)|uniprotkb:SERPINB6(gene name)|psi-mi:SERPINB6(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513200|imex:IM-28561-1243	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055872.4|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003646(Bacterial SH3-like region)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR012983(PHR)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR038648|mint:O75592|rcsb pdb:5O6C|rcsb pdb:6T7F|ensembl:ENSG00000005810(gene)|ensembl:ENST00000544440(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|dip:DIP-28142N	refseq:XP_011512975.1|refseq:XP_011512976.1|refseq:NP_004559.4|ensembl:ENSG00000124570(gene)|ensembl:ENST00000380520(transcript)|ensembl:ENST00000380524(transcript)|ensembl:ENST00000380529(transcript)|ensembl:ENST00000380539(transcript)|ensembl:ENST00000380546(transcript)|ensembl:ENST00000643098(transcript)|ensembl:ENST00000644178(transcript)|ensembl:ENST00000644388(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0097180"(serine protease inhibitor complex)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR023795|interpro:IPR023796|interpro:IPR036186|interpro:IPR042178|interpro:IPR042185|mint:P35237|reactome:R-HSA-6798695|reactome:R-HSA-75205|refseq:NP_001284628.1|refseq:NP_001284629.1|refseq:NP_001258751.1|refseq:NP_001258752.1|refseq:NP_001182220.2|refseq:NP_001258753.1|refseq:NP_001258754.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:AR3FR/zd48HkVinEfdT17ItGkbU9606	rogid:2MVIxMqFPJRBcrPFMTeN6os+hwI9606	rigid:Xp+xoCl6R5xTlsSzLZPVUuocl1Y	false	sufficient binding region:2540-3006	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O75592	uniprotkb:P46782	intact:EBI-1043774|uniprotkb:Q5JSX8|uniprotkb:Q5VZN6|uniprotkb:Q6PIB6|uniprotkb:Q9UQ11|uniprotkb:Q9Y6E4|uniprotkb:A6NJC6|ensembl:ENSP00000444596	intact:EBI-350569|uniprotkb:Q96BN0|uniprotkb:B2R4T2|ensembl:ENSP00000196551|ensembl:ENSP00000470114|ensembl:ENSP00000472985	psi-mi:mycb2_human(display_long)|uniprotkb:MYCBP2(gene name)|psi-mi:MYCBP2(display_short)|uniprotkb:KIAA0916(gene name synonym)|uniprotkb:PAM(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)	psi-mi:rs5_human(display_long)|uniprotkb:RPS5(gene name)|psi-mi:RPS5(display_short)|uniprotkb:Small ribosomal subunit protein uS7(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513191|imex:IM-28561-1711	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055872.4|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003646(Bacterial SH3-like region)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR012983(PHR)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR038648|mint:O75592|rcsb pdb:5O6C|rcsb pdb:6T7F|ensembl:ENSG00000005810(gene)|ensembl:ENST00000544440(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|dip:DIP-28142N	refseq:NP_001000.2|rcsb pdb:6OLZ|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBS|rcsb pdb:6Z6L|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6Z6M|rcsb pdb:6XA1|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6Y0G|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOL|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:5FLX|rcsb pdb:6OLG|rcsb pdb:6OLI|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|reactome:R-HSA-72706|ensembl:ENSG00000083845(gene)|ensembl:ENST00000196551(transcript)|ensembl:ENST00000596046(transcript)|ensembl:ENST00000601521(transcript)|go:"GO:0000028"(ribosomal small subunit assembly)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0006413"(translational initiation)|go:"GO:0006450"(regulation of translational fidelity)|go:"GO:0016020"(membrane)|go:"GO:0019843"(rRNA binding)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000235(Ribosomal protein S7)|interpro:IPR005716(Ribosomal protein S7, eukaryotic/archaeal)|interpro:IPR020606|interpro:IPR023798|interpro:IPR036823|mint:P46782|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|go:"GO:0003735"(structural constituent of ribosome)|rcsb pdb:5AJ0|reactome:R-HSA-72702	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:AR3FR/zd48HkVinEfdT17ItGkbU9606	rogid:SoCJdf2InngZZtlz5qD1k5CEfEo9606	rigid:4jmasNa5lXutpaTU1B5vOHDBINY	false	sufficient binding region:2540-3006	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O75592	uniprotkb:O14715	intact:EBI-1043774|uniprotkb:Q5JSX8|uniprotkb:Q5VZN6|uniprotkb:Q6PIB6|uniprotkb:Q9UQ11|uniprotkb:Q9Y6E4|uniprotkb:A6NJC6|ensembl:ENSP00000444596	intact:EBI-2560912|intact:EBI-28976328|ensembl:ENSP00000306637|uniprotkb:Q5CZA8	psi-mi:mycb2_human(display_long)|uniprotkb:MYCBP2(gene name)|psi-mi:MYCBP2(display_short)|uniprotkb:KIAA0916(gene name synonym)|uniprotkb:PAM(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)	psi-mi:rgpd8_human(display_long)|uniprotkb:RGPD8(gene name)|psi-mi:RGPD8(display_short)|uniprotkb:RANBP2ALPHA(gene name synonym)|uniprotkb:RANBP2L1(gene name synonym)|uniprotkb:RANBP2L3(gene name synonym)|uniprotkb:Ran-binding protein 2-like 3(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513182|imex:IM-28561-1241	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055872.4|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003646(Bacterial SH3-like region)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR012983(PHR)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR038648|mint:O75592|rcsb pdb:5O6C|rcsb pdb:6T7F|ensembl:ENSG00000005810(gene)|ensembl:ENST00000544440(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|dip:DIP-28142N	ensembl:ENSG00000169629(gene)|ensembl:ENST00000302558(transcript)|go:"GO:0005643"(nuclear pore)|go:"GO:0005737"(cytoplasm)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0031267"(small GTPase binding)|go:"GO:0050790"(regulation of catalytic activity)|interpro:IPR000156(Ran Binding Protein 1)|interpro:IPR000237(GRIP)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019734|interpro:IPR032023|mint:O14715|ensembl:ENSP00000306637|refseq:NP_001157935.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:AR3FR/zd48HkVinEfdT17ItGkbU9606	rogid:3f8A0lODSljzgqCoEQCUDHEkecE9606	rigid:aJmrJgqJmC+cZeHz1+vIr6f5pdc	false	sufficient binding region:2540-3006	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O75592	uniprotkb:Q9UHX1	intact:EBI-1043774|uniprotkb:Q5JSX8|uniprotkb:Q5VZN6|uniprotkb:Q6PIB6|uniprotkb:Q9UQ11|uniprotkb:Q9Y6E4|uniprotkb:A6NJC6|ensembl:ENSP00000444596	intact:EBI-1053259|uniprotkb:Q969E7|uniprotkb:Q96D94|uniprotkb:Q96H63|uniprotkb:Q99628|uniprotkb:Q9NZA0|uniprotkb:Q9UJY7|uniprotkb:A8K8K8|ensembl:ENSP00000434359|ensembl:ENSP00000484860	psi-mi:mycb2_human(display_long)|uniprotkb:MYCBP2(gene name)|psi-mi:MYCBP2(display_short)|uniprotkb:KIAA0916(gene name synonym)|uniprotkb:PAM(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)	psi-mi:puf60_human(display_long)|uniprotkb:"60 kDa poly(U)-binding-splicing factor"(gene name synonym)|uniprotkb:FUSE-binding protein-interacting repressor(gene name synonym)|uniprotkb:Siah-binding protein 1(gene name synonym)|uniprotkb:Ro-binding protein 1(gene name synonym)|uniprotkb:PUF60(gene name)|psi-mi:PUF60(display_short)|uniprotkb:SIAHBP1(gene name synonym)|uniprotkb:FIR(gene name synonym)|uniprotkb:ROBPI(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513173|imex:IM-28561-1035	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055872.4|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003646(Bacterial SH3-like region)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR012983(PHR)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR038648|mint:O75592|rcsb pdb:5O6C|rcsb pdb:6T7F|ensembl:ENSG00000005810(gene)|ensembl:ENST00000544440(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|dip:DIP-28142N	refseq:NP_001129505.1|refseq:NP_055096.2|refseq:NP_510965.1|refseq:NP_001258026.1|refseq:NP_001258028.1|refseq:NP_001258029.1|refseq:NP_001258025.1|refseq:NP_001258027.1|interpro:IPR034211|interpro:IPR034212|interpro:IPR035979|mint:Q9UHX1|rcsb pdb:2DNY|rcsb pdb:2KXF|rcsb pdb:2KXH|rcsb pdb:2QFJ|rcsb pdb:3DXB|rcsb pdb:3UE2|ensembl:ENSG00000179950(gene)|ensembl:ENSG00000274081(gene)|ensembl:ENST00000526683(transcript)|ensembl:ENST00000620341(transcript)|rcsb pdb:3US5|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|rcsb pdb:3UWT|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006376"(mRNA splice site selection)|go:"GO:0006915"(apoptotic process)|go:"GO:0030054"(cell junction)|rcsb pdb:5KVY|rcsb pdb:5KW1|rcsb pdb:5KW6|rcsb pdb:5KWQ|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR006532(Poly-U binding splicing factor, half-pint)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034209|rcsb pdb:6LUR|rcsb pdb:6SLO|reactome:R-HSA-72163|refseq:XP_016868728.1|refseq:XP_016868729.1|dip:DIP-34636N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:AR3FR/zd48HkVinEfdT17ItGkbU9606	rogid:nL6ALA543VdThkempiJTWAOhoNA9606	rigid:FoUqz1L2cJvPnyGPGUscQT03IQg	false	sufficient binding region:2540-3006	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O75592	uniprotkb:Q9UBF8	intact:EBI-1043774|uniprotkb:Q5JSX8|uniprotkb:Q5VZN6|uniprotkb:Q6PIB6|uniprotkb:Q9UQ11|uniprotkb:Q9Y6E4|uniprotkb:A6NJC6|ensembl:ENSP00000444596	intact:EBI-1053214|uniprotkb:B4DGI2|uniprotkb:O15096|uniprotkb:P78405|uniprotkb:Q5VWC1|uniprotkb:Q9BWR6|uniprotkb:Q5VWB9|uniprotkb:Q5VWC0|ensembl:ENSP00000357867	psi-mi:mycb2_human(display_long)|uniprotkb:MYCBP2(gene name)|psi-mi:MYCBP2(display_short)|uniprotkb:KIAA0916(gene name synonym)|uniprotkb:PAM(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)	psi-mi:pi4kb_human(display_long)|uniprotkb:NPIK(gene name synonym)|uniprotkb:PI4K92(gene name synonym)|uniprotkb:PI4KIII(gene name synonym)|uniprotkb:PI4KB(gene name)|psi-mi:PI4KB(display_short)|uniprotkb:PIK4CB(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513164|imex:IM-28561-793	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055872.4|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003646(Bacterial SH3-like region)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR012983(PHR)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR038648|mint:O75592|rcsb pdb:5O6C|rcsb pdb:6T7F|ensembl:ENSG00000005810(gene)|ensembl:ENST00000544440(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|dip:DIP-28142N	refseq:NP_001185702.1|refseq:NP_001185703.1|refseq:NP_001185704.1|refseq:NP_002642.1|ensembl:ENSG00000143393(gene)|ensembl:ENST00000368873(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0004430"(1-phosphatidylinositol 4-kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0030867"(rough endoplasmic reticulum membrane)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0071889"(14-3-3 protein binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR018936|interpro:IPR036940|mint:Q9UBF8|rcsb pdb:2N73|rcsb pdb:4D0L|rcsb pdb:4D0M|rcsb pdb:4WAE|rcsb pdb:4WAG|rcsb pdb:5C46|rcsb pdb:5C4G|rcsb pdb:5EUQ|rcsb pdb:5FBL|rcsb pdb:5FBQ|rcsb pdb:5FBR|rcsb pdb:5FBV|rcsb pdb:5FBW|rcsb pdb:5LX2|rcsb pdb:5NAS|rcsb pdb:6GL3|reactome:R-HSA-1660514|refseq:NP_001317650.1|refseq:XP_016856979.1|refseq:XP_016856980.1|refseq:XP_016856981.1|dip:DIP-42267N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:AR3FR/zd48HkVinEfdT17ItGkbU9606	rogid:EeU4q6eJ1Kji9EaWCT+xYv2Y8eA9606	rigid:uAKHlkhV1kq7fAptjxLHwB//qP8	false	sufficient binding region:1-494	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O75592	uniprotkb:Q86U42	intact:EBI-1043774|uniprotkb:Q5JSX8|uniprotkb:Q5VZN6|uniprotkb:Q6PIB6|uniprotkb:Q9UQ11|uniprotkb:Q9Y6E4|uniprotkb:A6NJC6|ensembl:ENSP00000444596	intact:EBI-1226435|uniprotkb:O43484|uniprotkb:D3DS49|ensembl:ENSP00000216727	psi-mi:mycb2_human(display_long)|uniprotkb:MYCBP2(gene name)|psi-mi:MYCBP2(display_short)|uniprotkb:KIAA0916(gene name synonym)|uniprotkb:PAM(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)	psi-mi:pabp2_human(display_long)|uniprotkb:PABPN1(gene name)|psi-mi:PABPN1(display_short)|uniprotkb:PAB2(gene name synonym)|uniprotkb:PABP2(gene name synonym)|uniprotkb:"Poly(A)-binding protein II"(gene name synonym)|uniprotkb:Polyadenylate-binding nuclear protein 1(gene name synonym)|uniprotkb:"Nuclear poly(A)-binding protein 1"(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513155|imex:IM-28561-791	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055872.4|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003646(Bacterial SH3-like region)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR012983(PHR)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR038648|mint:O75592|rcsb pdb:5O6C|rcsb pdb:6T7F|ensembl:ENSG00000005810(gene)|ensembl:ENST00000544440(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|dip:DIP-28142N	refseq:NP_004634.1|dip:DIP-37968N|go:"GO:0000165"(MAPK cascade)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006396"(RNA processing)|go:"GO:0006397"(mRNA processing)|ensembl:ENSG00000100836(gene)|ensembl:ENST00000216727(transcript)|go:"GO:0006936"(muscle contraction)|go:"GO:0016607"(nuclear speck)|go:"GO:0016973"("poly(A)+ mRNA export from nucleus")|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1904247"(positive regulation of polynucleotide adenylyltransferase activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034911|interpro:IPR035979|mint:Q86U42|rcsb pdb:3B4D|rcsb pdb:3B4M|rcsb pdb:3UCG|reactome:R-HSA-168315|reactome:R-HSA-72163|reactome:R-HSA-72187|reactome:R-HSA-73856|reactome:R-HSA-77595|go:"GO:0070063"(RNA polymerase binding)	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:AR3FR/zd48HkVinEfdT17ItGkbU9606	rogid:NxWuFTvVqshfu+ZIsZMIZEdSk2k9606	rigid:h1LxunT2becXLbE9yACKJI58DW0	false	sufficient binding region:2540-3006	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O75592	uniprotkb:P54368	intact:EBI-1043774|uniprotkb:Q5JSX8|uniprotkb:Q5VZN6|uniprotkb:Q6PIB6|uniprotkb:Q9UQ11|uniprotkb:Q9Y6E4|uniprotkb:A6NJC6|ensembl:ENSP00000444596	intact:EBI-948441|ensembl:ENSP00000473381|uniprotkb:O43382|uniprotkb:Q14989|uniprotkb:Q92595|uniprotkb:Q9UPL9	psi-mi:mycb2_human(display_long)|uniprotkb:MYCBP2(gene name)|psi-mi:MYCBP2(display_short)|uniprotkb:KIAA0916(gene name synonym)|uniprotkb:PAM(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)	psi-mi:oaz1_human(display_long)|uniprotkb:OAZ1(gene name)|psi-mi:OAZ1(display_short)|uniprotkb:OAZ(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513146|imex:IM-28561-1239	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055872.4|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003646(Bacterial SH3-like region)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR012983(PHR)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR038648|mint:O75592|rcsb pdb:5O6C|rcsb pdb:6T7F|ensembl:ENSG00000005810(gene)|ensembl:ENST00000544440(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|dip:DIP-28142N	ensembl:ENSG00000104904(gene)|ensembl:ENST00000602676(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006596"(polyamine biosynthetic process)|go:"GO:0008073"(ornithine decarboxylase inhibitor activity)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:1902268"(negative regulation of polyamine transmembrane transport)|interpro:IPR002993(Ornithine decarboxylase antizyme)|interpro:IPR016181(Acyl-CoA N-acyltransferase)|interpro:IPR029914|mint:P54368|rcsb pdb:4ZGY|rcsb pdb:4ZGZ|rcsb pdb:5BWA|reactome:R-HSA-350562|interpro:IPR038581|refseq:NP_004143.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:AR3FR/zd48HkVinEfdT17ItGkbU9606	rogid:rrf1LoIm0F76PUQlVAva8tbH+w49606	rigid:brpdag+Rrkjw0gewseMIB78mZBs	false	sufficient binding region:2540-3006	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O75592	uniprotkb:Q9Y6M9	intact:EBI-1043774|uniprotkb:Q5JSX8|uniprotkb:Q5VZN6|uniprotkb:Q6PIB6|uniprotkb:Q9UQ11|uniprotkb:Q9Y6E4|uniprotkb:A6NJC6|ensembl:ENSP00000444596	intact:EBI-713654|uniprotkb:Q9UQE8|uniprotkb:B2R8M6|ensembl:ENSP00000276689|ensembl:ENSP00000504235	psi-mi:mycb2_human(display_long)|uniprotkb:MYCBP2(gene name)|psi-mi:MYCBP2(display_short)|uniprotkb:KIAA0916(gene name synonym)|uniprotkb:PAM(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)	psi-mi:ndub9_human(display_long)|uniprotkb:LYRM3(gene name synonym)|uniprotkb:NADH-ubiquinone oxidoreductase B22 subunit(gene name synonym)|uniprotkb:Complex I-B22(gene name synonym)|uniprotkb:LYR motif-containing protein 3(gene name synonym)|uniprotkb:NDUFB9(gene name)|psi-mi:NDUFB9(display_short)|uniprotkb:UQOR22(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513137|imex:IM-28561-361	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055872.4|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003646(Bacterial SH3-like region)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR012983(PHR)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR038648|mint:O75592|rcsb pdb:5O6C|rcsb pdb:6T7F|ensembl:ENSG00000005810(gene)|ensembl:ENST00000544440(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|dip:DIP-28142N	rcsb pdb:5XTH|rcsb pdb:5XTD|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198|ensembl:ENSG00000147684(gene)|ensembl:ENST00000276689(transcript)|ensembl:ENST00000677021(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR008011(Complex 1 LYR protein)|interpro:IPR033034|mint:Q9Y6M9|rcsb pdb:5XTC|refseq:NP_001298097.1|refseq:NP_004996.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:AR3FR/zd48HkVinEfdT17ItGkbU9606	rogid:sNQcYhIFMHZA5T6MeeiwAeAJ5Gs9606	rigid:3ZQRtDrJUZEsSgxL1toPS2t64y0	false	sufficient binding region:2540-3006	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O75592	uniprotkb:Q8ND56	intact:EBI-1043774|uniprotkb:Q5JSX8|uniprotkb:Q5VZN6|uniprotkb:Q6PIB6|uniprotkb:Q9UQ11|uniprotkb:Q9Y6E4|uniprotkb:A6NJC6|ensembl:ENSP00000444596	intact:EBI-1384320|uniprotkb:Q76LX7|uniprotkb:Q96AR3|uniprotkb:Q96K73|uniprotkb:Q96SN5|uniprotkb:Q9UFR3|intact:EBI-2563702|uniprotkb:B4DTG6|ensembl:ENSP00000413964|ensembl:ENSP00000459843	psi-mi:mycb2_human(display_long)|uniprotkb:MYCBP2(gene name)|psi-mi:MYCBP2(display_short)|uniprotkb:KIAA0916(gene name synonym)|uniprotkb:PAM(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)	psi-mi:ls14a_human(display_long)|uniprotkb:C19orf13(gene name synonym)|uniprotkb:FAM61A(gene name synonym)|uniprotkb:Protein SCD6 homolog(gene name synonym)|uniprotkb:Protein FAM61A(gene name synonym)|uniprotkb:Putative alpha-synuclein-binding protein(gene name synonym)|uniprotkb:LSM14A(gene name)|psi-mi:LSM14A(display_short)|uniprotkb:RAP55(gene name synonym)|uniprotkb:RAP55A(gene name synonym)|uniprotkb:RNA-associated protein 55A(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513128|imex:IM-28561-1237	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055872.4|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003646(Bacterial SH3-like region)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR012983(PHR)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR038648|mint:O75592|rcsb pdb:5O6C|rcsb pdb:6T7F|ensembl:ENSG00000005810(gene)|ensembl:ENST00000544440(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|dip:DIP-28142N	refseq:NP_001107565.1|refseq:NP_056393.2|go:"GO:0072686"(mitotic spindle)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:1990124"(messenger ribonucleoprotein complex)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR019050|interpro:IPR025609|interpro:IPR025761|interpro:IPR025762|interpro:IPR025768|mint:Q8ND56|rcsb pdb:6F9W|ensembl:ENSG00000257103(gene)|ensembl:ENSG00000262860(gene)|ensembl:ENST00000433627(transcript)|ensembl:ENST00000570462(transcript)|go:"GO:0000932"(P-body)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0033962"(P-body assembly)|go:"GO:0034063"(stress granule assembly)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0039529"(RIG-I signaling pathway)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:AR3FR/zd48HkVinEfdT17ItGkbU9606	rogid:YW/zx4XyhcZZr3WCZIr1OVpyakA9606	rigid:44l0vui597e7ZmirrmadRC5gTxw	false	sufficient binding region:2540-3006	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O75592	uniprotkb:P07195	intact:EBI-1043774|uniprotkb:Q5JSX8|uniprotkb:Q5VZN6|uniprotkb:Q6PIB6|uniprotkb:Q9UQ11|uniprotkb:Q9Y6E4|uniprotkb:A6NJC6|ensembl:ENSP00000444596	intact:EBI-358748|ensembl:ENSP00000229319|ensembl:ENSP00000379386	psi-mi:mycb2_human(display_long)|uniprotkb:MYCBP2(gene name)|psi-mi:MYCBP2(display_short)|uniprotkb:KIAA0916(gene name synonym)|uniprotkb:PAM(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)	psi-mi:ldhb_human(display_long)|uniprotkb:LDHB(gene name)|psi-mi:LDHB(display_short)|uniprotkb:LDH heart subunit(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-46(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513119|imex:IM-28561-1235	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055872.4|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003646(Bacterial SH3-like region)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR012983(PHR)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR038648|mint:O75592|rcsb pdb:5O6C|rcsb pdb:6T7F|ensembl:ENSG00000005810(gene)|ensembl:ENST00000544440(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|dip:DIP-28142N	refseq:NP_001167568.1|refseq:NP_002291.1|refseq:NP_001302466.1|ensembl:ENSG00000111716(gene)|ensembl:ENST00000350669(transcript)|ensembl:ENST00000396076(transcript)|go:"GO:0004459"(L-lactate dehydrogenase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0016020"(membrane)|go:"GO:0019752"(carboxylic acid metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001236(Lactate/malate dehydrogenase)|interpro:IPR001557(L-lactate/malate dehydrogenase)|interpro:IPR011304(L-lactate dehydrogenase)|interpro:IPR015955(Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal)|interpro:IPR018177|interpro:IPR022383|interpro:IPR036291|mint:P07195|rcsb pdb:1I0Z|rcsb pdb:1T2F|reactome:R-HSA-70268	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:AR3FR/zd48HkVinEfdT17ItGkbU9606	rogid:umdj6fjSO7+4SM9Hrl1/K2EiKls9606	rigid:ToVvlfQhtJkHkVXDG8ZUr4xqJ7E	false	sufficient binding region:2540-3006	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9NZ94	uniprotkb:P54253	intact:EBI-3920184|uniprotkb:Q9NZ95|uniprotkb:Q9NZ96|uniprotkb:D3DVV0|uniprotkb:Q9NZ97|uniprotkb:Q9P248|uniprotkb:Q8NCD0|ensembl:ENSP00000351591|uniprotkb:D3DVV1|uniprotkb:B2RBK1|uniprotkb:D2X2H6|uniprotkb:Q86V51	intact:EBI-930964|uniprotkb:Q17S02|uniprotkb:Q9UJG2|uniprotkb:Q9Y4J1|ensembl:ENSP00000244769|ensembl:ENSP00000416360	psi-mi:nlgn3_human(display_long)|uniprotkb:NLGN3(gene name)|psi-mi:NLGN3(display_short)|uniprotkb:KIAA1480(gene name synonym)|uniprotkb:NL3(gene name synonym)|uniprotkb:Gliotactin homolog(gene name synonym)	psi-mi:atx1_human(display_long)|uniprotkb:ATXN1(gene name)|psi-mi:ATXN1(display_short)|uniprotkb:ATX1(gene name synonym)|uniprotkb:SCA1(gene name synonym)|uniprotkb:Spinocerebellar ataxia type 1 protein(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513308|imex:IM-28561-149	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0098793"(presynapse)|refseq:NP_001160132.1|refseq:NP_061850.2|refseq:NP_851820.1|ensembl:ENSG00000196338(gene)|ensembl:ENST00000358741(transcript)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0009986"(cell surface)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030534"(adult behavior)|go:"GO:0035176"(social behavior)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0045202"(synapse)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048675"(axon extension)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050808"(synapse organization)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060024"(rhythmic synaptic transmission)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0071625"(vocalization behavior)|go:"GO:0089717"(spanning component of membrane)|go:"GO:0097104"(postsynaptic membrane assembly)|go:"GO:0097105"(presynaptic membrane assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098985"(asymmetric, glutamatergic, excitatory synapse)|go:"GO:0099054"(presynapse assembly)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR000460(Neuroligin)|interpro:IPR002018(Carboxylesterase, type B)|interpro:IPR019819|interpro:IPR029058|interpro:IPR030024|mint:Q9NZ94|reactome:R-HSA-6794361|go:"GO:0098983"(symmetric, GABA-ergic, inhibitory synapse)|refseq:NP_001308205.1	refseq:NP_000323.2|refseq:NP_001121636.1|dip:DIP-35353N|ensembl:ENSG00000124788(gene)|ensembl:ENST00000244769(transcript)|ensembl:ENST00000436367(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006396"(RNA processing)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0016363"(nuclear matrix)|go:"GO:0034046"("poly(G) binding")|go:"GO:0035176"(social behavior)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042802"(identical protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048856"(anatomical structure development)|go:"GO:0051168"(nuclear export)|interpro:IPR003652(Ataxin, AXH region)|interpro:IPR036096|interpro:IPR040172|interpro:IPR043404|mint:P54253|rcsb pdb:1OA8|rcsb pdb:2M41|rcsb pdb:4APT|rcsb pdb:4AQP|rcsb pdb:4J2J|rcsb pdb:4J2L|rcsb pdb:6QIU	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:OzGAr78JAaopeMCBpHnhVXP5DaU9606	rogid:DodgC3h3y3QNOd7da7+XB/MPPfQ9606	rigid:gcOSjYj3TfqZL9cZ6uLEcfKgX1U	false	sufficient binding region:712-848	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9NZ94	uniprotkb:O95996	intact:EBI-3920184|uniprotkb:Q9NZ95|uniprotkb:Q9NZ96|uniprotkb:D3DVV0|uniprotkb:Q9NZ97|uniprotkb:Q9P248|uniprotkb:Q8NCD0|ensembl:ENSP00000351591|uniprotkb:D3DVV1|uniprotkb:B2RBK1|uniprotkb:D2X2H6|uniprotkb:Q86V51	intact:EBI-1053045|uniprotkb:Q05BW4|uniprotkb:Q9UBZ1|uniprotkb:Q9UEM8|uniprotkb:Q9UQJ8|uniprotkb:Q9UQJ9|uniprotkb:Q9Y632|ensembl:ENSP00000233607|ensembl:ENSP00000442954|ensembl:ENSP00000467073	psi-mi:nlgn3_human(display_long)|uniprotkb:NLGN3(gene name)|psi-mi:NLGN3(display_short)|uniprotkb:KIAA1480(gene name synonym)|uniprotkb:NL3(gene name synonym)|uniprotkb:Gliotactin homolog(gene name synonym)	psi-mi:apcl_human(display_long)|uniprotkb:Adenomatous polyposis coli protein-like(gene name synonym)|uniprotkb:APC2(gene name)|psi-mi:APC2(display_short)|uniprotkb:APCL(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513299|imex:IM-28561-1247	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0098793"(presynapse)|refseq:NP_001160132.1|refseq:NP_061850.2|refseq:NP_851820.1|ensembl:ENSG00000196338(gene)|ensembl:ENST00000358741(transcript)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0009986"(cell surface)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030534"(adult behavior)|go:"GO:0035176"(social behavior)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0045202"(synapse)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048675"(axon extension)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050808"(synapse organization)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060024"(rhythmic synaptic transmission)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0071625"(vocalization behavior)|go:"GO:0089717"(spanning component of membrane)|go:"GO:0097104"(postsynaptic membrane assembly)|go:"GO:0097105"(presynaptic membrane assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098985"(asymmetric, glutamatergic, excitatory synapse)|go:"GO:0099054"(presynapse assembly)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR000460(Neuroligin)|interpro:IPR002018(Carboxylesterase, type B)|interpro:IPR019819|interpro:IPR029058|interpro:IPR030024|mint:Q9NZ94|reactome:R-HSA-6794361|go:"GO:0098983"(symmetric, GABA-ergic, inhibitory synapse)|refseq:NP_001308205.1	refseq:NP_005874.1|ensembl:ENSP00000233607|ensembl:ENSP00000442954|ensembl:ENSP00000467073|ensembl:ENSG00000115266(gene)|ensembl:ENST00000233607(transcript)|ensembl:ENST00000535453(transcript)|ensembl:ENST00000590469(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001708"(cell fate specification)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005884"(actin filament)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007389"(pattern specification process)|go:"GO:0007399"(nervous system development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0030496"(midbody)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR000225(Armadillo)|interpro:IPR009223(APC cysteine-rich)|interpro:IPR009224(SAMP)|interpro:IPR009234(APC basic)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026818|interpro:IPR026831|interpro:IPR026837|interpro:IPR032038|interpro:IPR036149|interpro:IPR041257|mint:O95996|refseq:XP_006722672.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:OzGAr78JAaopeMCBpHnhVXP5DaU9606	rogid:v1BSNAoDD3R0+lrhI5zsOZvxFjQ9606	rigid:4ZZUHpvg83rcFk4kGsH4qsQfWlI	false	sufficient binding region:712-848	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9NZ94	uniprotkb:P31749	intact:EBI-3920184|uniprotkb:Q9NZ95|uniprotkb:Q9NZ96|uniprotkb:D3DVV0|uniprotkb:Q9NZ97|uniprotkb:Q9P248|uniprotkb:Q8NCD0|ensembl:ENSP00000351591|uniprotkb:D3DVV1|uniprotkb:B2RBK1|uniprotkb:D2X2H6|uniprotkb:Q86V51	intact:EBI-296087|uniprotkb:Q9BWB6|ensembl:ENSP00000270202|ensembl:ENSP00000384293|ensembl:ENSP00000385326|ensembl:ENSP00000450688|ensembl:ENSP00000451166|ensembl:ENSP00000451828|ensembl:ENSP00000507879|ensembl:ENSP00000497822|uniprotkb:B2RAM5|uniprotkb:B7Z5R1	psi-mi:nlgn3_human(display_long)|uniprotkb:NLGN3(gene name)|psi-mi:NLGN3(display_short)|uniprotkb:KIAA1480(gene name synonym)|uniprotkb:NL3(gene name synonym)|uniprotkb:Gliotactin homolog(gene name synonym)	psi-mi:akt1_human(display_long)|uniprotkb:AKT1(gene name)|psi-mi:AKT1(display_short)|uniprotkb:PKB(gene name synonym)|uniprotkb:RAC(gene name synonym)|uniprotkb:RAC-PK-alpha(gene name synonym)|uniprotkb:Protein kinase B(gene name synonym)|uniprotkb:Proto-oncogene c-Akt(gene name synonym)|uniprotkb:Protein kinase B alpha(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513290|imex:IM-28561-1245	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0098793"(presynapse)|refseq:NP_001160132.1|refseq:NP_061850.2|refseq:NP_851820.1|ensembl:ENSG00000196338(gene)|ensembl:ENST00000358741(transcript)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0009986"(cell surface)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030534"(adult behavior)|go:"GO:0035176"(social behavior)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0045202"(synapse)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048675"(axon extension)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050808"(synapse organization)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060024"(rhythmic synaptic transmission)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0071625"(vocalization behavior)|go:"GO:0089717"(spanning component of membrane)|go:"GO:0097104"(postsynaptic membrane assembly)|go:"GO:0097105"(presynaptic membrane assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098985"(asymmetric, glutamatergic, excitatory synapse)|go:"GO:0099054"(presynapse assembly)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR000460(Neuroligin)|interpro:IPR002018(Carboxylesterase, type B)|interpro:IPR019819|interpro:IPR029058|interpro:IPR030024|mint:Q9NZ94|reactome:R-HSA-6794361|go:"GO:0098983"(symmetric, GABA-ergic, inhibitory synapse)|refseq:NP_001308205.1	go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0008643"(carbohydrate transport)|go:"GO:0009408"(response to heat)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010748"(negative regulation of long-chain fatty acid import across plasma membrane)|go:"GO:0010761"(fibroblast migration)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0007568"(aging)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0021510"(spinal cord development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030154"(cell differentiation)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030212"(hyaluronan metabolic process)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043276"(anoikis)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|ensembl:ENSG00000142208(gene)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031641"(regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031929"(TOR signaling)|go:"GO:0031982"(vesicle)|go:"GO:0031999"(negative regulation of fatty acid beta-oxidation)|go:"GO:0032079"(positive regulation of endodeoxyribonuclease activity)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032094"(response to food)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032287"(peripheral nervous system myelin maintenance)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032929"(negative regulation of superoxide anion generation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034405"(response to fluid shear stress)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035655"(interleukin-18-mediated signaling pathway)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|ensembl:ENST00000349310(transcript)|ensembl:ENST00000402615(transcript)|ensembl:ENST00000407796(transcript)|ensembl:ENST00000554581(transcript)|ensembl:ENST00000554848(transcript)|ensembl:ENST00000555528(transcript)|ensembl:ENST00000649815(transcript)|ensembl:ENST00000683722(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0002931"(response to ischemia)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006412"(translation)|go:"GO:0006417"(regulation of translation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0006924"(activation-induced cell death of T cells)|go:"GO:0006954"(inflammatory response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007281"(germ cell development)|go:"GO:0005739"(mitochondrion)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0060709"(glycogen cell differentiation involved in embryonic placenta development)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0070141"(response to UV-A)|go:"GO:0070848"(response to growth factor)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0072655"(establishment of protein localization to mitochondrion)|go:"GO:0072656"(maintenance of protein location in mitochondrion)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0098794"(postsynapse)|go:"GO:0099104"(potassium channel activator activity)|go:"GO:0100002"(negative regulation of protein kinase activity by protein phosphorylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0110099"(negative regulation of calcium import into the mitochondrion)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903038"(negative regulation of leukocyte cell-cell adhesion)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990418"(response to insulin-like growth factor stimulus)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000074"(regulation of type B pancreatic cell development)|go:"GO:2000402"(negative regulation of lymphocyte migration)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR034676|interpro:IPR039026|interpro:IPR039027|mint:P31749|rcsb pdb:1H10|rcsb pdb:1UNP|rcsb pdb:1UNQ|reactome:R-HSA-1474151|reactome:R-HSA-165159|reactome:R-HSA-198323|reactome:R-HSA-198693|reactome:R-HSA-199418|reactome:R-HSA-203615|reactome:R-HSA-211163|reactome:R-HSA-354192|reactome:R-HSA-3769402|reactome:R-HSA-389357|reactome:R-HSA-389513|reactome:R-HSA-392451|reactome:R-HSA-450385|reactome:R-HSA-450604|reactome:R-HSA-5218920|rcsb pdb:6S9X|reactome:R-HSA-5628897|reactome:R-HSA-5674400|reactome:R-HSA-111447|reactome:R-HSA-6785807|reactome:R-HSA-6804757|reactome:R-HSA-6804758|reactome:R-HSA-6804759|reactome:R-HSA-1257604|reactome:R-HSA-1358803|reactome:R-HSA-1445148|reactome:R-HSA-6811558|reactome:R-HSA-69202|reactome:R-HSA-69656|reactome:R-HSA-8849469|reactome:R-HSA-8876198|reactome:R-HSA-8941332|reactome:R-HSA-8948751|reactome:R-HSA-9009391|rcsb pdb:1UNR|rcsb pdb:2UVM|rcsb pdb:2UZR|rcsb pdb:2UZS|rcsb pdb:3CQU|rcsb pdb:3CQW|rcsb pdb:3MV5|rcsb pdb:3MVH|rcsb pdb:3O96|rcsb pdb:3OCB|rcsb pdb:3OW4|rcsb pdb:3QKK|rcsb pdb:3QKL|rcsb pdb:3QKM|rcsb pdb:4EJN|rcsb pdb:4EKK|rcsb pdb:4EKL|rcsb pdb:4GV1|rcsb pdb:5KCV|rcsb pdb:6BUU|rcsb pdb:6CCY|rcsb pdb:6HHF|rcsb pdb:6HHG|rcsb pdb:6HHH|rcsb pdb:6HHI|rcsb pdb:6HHJ|rcsb pdb:6NPZ|rcsb pdb:6S9W|reactome:R-HSA-9607240|reactome:R-HSA-9614399|reactome:R-HSA-9634638|reactome:R-HSA-9604323|refseq:NP_001014431.1|refseq:NP_001014432.1|refseq:NP_005154.2|refseq:XP_005267458.1|dip:DIP-24269N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:OzGAr78JAaopeMCBpHnhVXP5DaU9606	rogid:9bYBB1SbEBm+NM0maKOC5Bx6KlI9606	rigid:8o7DooX8F+W9qz1StZzIUn3P1R0	false	sufficient binding region:712-848	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9NZ94	uniprotkb:Q08117	intact:EBI-3920184|uniprotkb:Q9NZ95|uniprotkb:Q9NZ96|uniprotkb:D3DVV0|uniprotkb:Q9NZ97|uniprotkb:Q9P248|uniprotkb:Q8NCD0|ensembl:ENSP00000351591|uniprotkb:D3DVV1|uniprotkb:B2RBK1|uniprotkb:D2X2H6|uniprotkb:Q86V51	intact:EBI-717810|uniprotkb:Q12808|uniprotkb:Q96TG9|uniprotkb:Q9UDY9|uniprotkb:B2RBL0|uniprotkb:Q14CJ1|ensembl:ENSP00000317537	psi-mi:nlgn3_human(display_long)|uniprotkb:NLGN3(gene name)|psi-mi:NLGN3(display_short)|uniprotkb:KIAA1480(gene name synonym)|uniprotkb:NL3(gene name synonym)|uniprotkb:Gliotactin homolog(gene name synonym)	psi-mi:tle5_human(display_long)|uniprotkb:TLE5(gene name)|psi-mi:TLE5(display_short)|uniprotkb:AES(gene name synonym)|uniprotkb:Amino-terminal enhancer of split(gene name synonym)|uniprotkb:GRG(gene name synonym)|uniprotkb:GRG5(gene name synonym)|uniprotkb:Gp130-associated protein GAM(gene name synonym)|uniprotkb:Grg-5(gene name synonym)|uniprotkb:Groucho-related protein 5(gene name synonym)|uniprotkb:Protein ESP1(gene name synonym)|uniprotkb:Protein GRG(gene name synonym)|uniprotkb:TLE family member 5, transcriptional modulator(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513281|imex:IM-28561-1041	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0098793"(presynapse)|refseq:NP_001160132.1|refseq:NP_061850.2|refseq:NP_851820.1|ensembl:ENSG00000196338(gene)|ensembl:ENST00000358741(transcript)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0009986"(cell surface)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030534"(adult behavior)|go:"GO:0035176"(social behavior)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0045202"(synapse)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048675"(axon extension)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050808"(synapse organization)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060024"(rhythmic synaptic transmission)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0071625"(vocalization behavior)|go:"GO:0089717"(spanning component of membrane)|go:"GO:0097104"(postsynaptic membrane assembly)|go:"GO:0097105"(presynaptic membrane assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098985"(asymmetric, glutamatergic, excitatory synapse)|go:"GO:0099054"(presynapse assembly)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR000460(Neuroligin)|interpro:IPR002018(Carboxylesterase, type B)|interpro:IPR019819|interpro:IPR029058|interpro:IPR030024|mint:Q9NZ94|reactome:R-HSA-6794361|go:"GO:0098983"(symmetric, GABA-ergic, inhibitory synapse)|refseq:NP_001308205.1	refseq:NP_001121.2|refseq:NP_945320.1|refseq:NP_945321.1|ensembl:ENSG00000104964(gene)|ensembl:ENST00000327141(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001501"(skeletal system development)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0007275"(multicellular organism development)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0040008"(regulation of growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0060761"(negative regulation of response to cytokine stimulus)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000210"(positive regulation of anoikis)|interpro:IPR005617(Groucho/TLE, N-terminal Q-rich region)|interpro:IPR009146(Groucho/transducin-like enhancer)|mint:Q08117|reactome:R-HSA-4641265|go:"GO:0032091"(negative regulation of protein binding)	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:OzGAr78JAaopeMCBpHnhVXP5DaU9606	rogid:eveYX2Rj6Oz431E8nGcTk4bUNt89606	rigid:P64Tq8JrFza/Epafy75LxSGPZA8	false	sufficient binding region:712-848	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P21359	uniprotkb:O43281	intact:EBI-1172917|uniprotkb:O00662|uniprotkb:Q14284|uniprotkb:Q14930|uniprotkb:Q9UMK3|uniprotkb:Q14931|ensembl:ENSP00000351015	intact:EBI-718488|uniprotkb:O43282|uniprotkb:B2RAJ7|uniprotkb:B4DJ56|uniprotkb:E9PGU2|ensembl:ENSP00000216733	psi-mi:nf1_human(display_long)|uniprotkb:NF1(gene name)|psi-mi:NF1(display_short)|uniprotkb:Neurofibromatosis-related protein NF-1(gene name synonym)	psi-mi:efs_human(display_long)|uniprotkb:EFS(gene name)|psi-mi:EFS(display_short)|uniprotkb:CASS3(gene name synonym)|uniprotkb:Cas scaffolding protein family member 3(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513272|imex:IM-28561-365	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000258.1|refseq:NP_001035957.1|refseq:NP_001121619.1|ensembl:ENSG00000196712(gene)|ensembl:ENST00000358273(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001656"(metanephros development)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001889"(liver development)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007154"(cell communication)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0007420"(brain development)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0008429"(phosphatidylethanolamine binding)|go:"GO:0008542"(visual learning)|go:"GO:0014044"(Schwann cell development)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0021510"(spinal cord development)|go:"GO:0021897"(forebrain astrocyte development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0022011"(myelination in peripheral nervous system)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030325"(adrenal gland development)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0042060"(wound healing)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043473"(pigmentation)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043535"(regulation of blood vessel endothelial cell migration)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045124"(regulation of bone resorption)|go:"GO:0045685"(regulation of glial cell differentiation)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048485"(sympathetic nervous system development)|go:"GO:0048593"(camera-type eye morphogenesis)|go:"GO:0048715"(negative regulation of oligodendrocyte differentiation)|go:"GO:0048745"(smooth muscle tissue development)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0050890"(cognition)|interpro:IPR001251(Cellular retinaldehyde-binding/triple function, C-terminal)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR023152|interpro:IPR036865|interpro:IPR039360|mint:P21359|rcsb pdb:1NF1|rcsb pdb:2E2X|rcsb pdb:3P7Z|rcsb pdb:3PEG|rcsb pdb:3PG7|rcsb pdb:6OB2|rcsb pdb:6OB3|rcsb pdb:6V65|rcsb pdb:6V6F|reactome:R-HSA-5658442|reactome:R-HSA-6802953|rcsb pdb:2D4Q	refseq:NP_005855.1|refseq:NP_115835.1|refseq:NP_001264103.1|ensembl:ENSP00000216733|ensembl:ENST00000351354|ensembl:ENSP00000340607|ensembl:ENST00000429593|ensembl:ENSP00000416684|ensembl:ENSG00000100842(gene)|ensembl:ENST00000216733(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0090527"(actin filament reorganization)|interpro:IPR001452(Src homology-3)|interpro:IPR021901|interpro:IPR035747|interpro:IPR036028|interpro:IPR037362|mint:O43281	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:9/AAe+70biVtuhfi0XOaUUkg4D09606	rogid:7aO8sdSXU6RqHKK6NnxYRwcDet09606	rigid:w/GeXtfG9KKLRwGvvtpwl+96WPw	false	sufficient binding region:1737-2320	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O75592	uniprotkb:P09936	intact:EBI-1043774|uniprotkb:Q5JSX8|uniprotkb:Q5VZN6|uniprotkb:Q6PIB6|uniprotkb:Q9UQ11|uniprotkb:Q9Y6E4|uniprotkb:A6NJC6|ensembl:ENSP00000444596	intact:EBI-714860|uniprotkb:Q71UM0|intact:EBI-1049220|uniprotkb:Q4W5K6|ensembl:ENSP00000284440|ensembl:ENSP00000422542	psi-mi:mycb2_human(display_long)|uniprotkb:MYCBP2(gene name)|psi-mi:MYCBP2(display_short)|uniprotkb:KIAA0916(gene name synonym)|uniprotkb:PAM(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)	psi-mi:uchl1_human(display_long)|uniprotkb:Ubiquitin thioesterase L1(gene name synonym)|uniprotkb:Neuron cytoplasmic protein 9.5(gene name synonym)|uniprotkb:PGP 9.5(gene name synonym)|uniprotkb:UCHL1(gene name)|psi-mi:UCHL1(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513263|imex:IM-28561-363	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055872.4|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003646(Bacterial SH3-like region)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR012983(PHR)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR038648|mint:O75592|rcsb pdb:5O6C|rcsb pdb:6T7F|ensembl:ENSG00000005810(gene)|ensembl:ENST00000544440(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|dip:DIP-28142N	refseq:NP_004172.2|ensembl:ENSG00000154277(gene)|ensembl:ENST00000284440(transcript)|ensembl:ENST00000503431(transcript)|go:"GO:0002931"(response to ischemia)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0007412"(axon target recognition)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008242"(omega peptidase activity)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016874"(ligase activity)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019896"(axonal transport of mitochondrion)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031694"(alpha-2A adrenergic receptor binding)|go:"GO:0035690"|go:"GO:0042755"(eating behavior)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0050905"(neuromuscular process)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR001578(Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1)|interpro:IPR030297|interpro:IPR036959|interpro:IPR038765|mint:P09936|rcsb pdb:2ETL|rcsb pdb:2LEN|rcsb pdb:3IFW|rcsb pdb:3IRT|rcsb pdb:3KVF|rcsb pdb:3KW5|rcsb pdb:4DM9|rcsb pdb:4JKJ|reactome:R-HSA-5689603|go:"GO:0055001"(muscle cell development)|dip:DIP-36620N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:AR3FR/zd48HkVinEfdT17ItGkbU9606	rogid:bQ3cxdH+e5fTg7KZ1wjHcOd9cIs9606	rigid:ZfLyMmPTIg7IMbpwZHIKPEouvuM	false	sufficient binding region:2540-3006	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O75592	uniprotkb:Q16650	intact:EBI-1043774|uniprotkb:Q5JSX8|uniprotkb:Q5VZN6|uniprotkb:Q6PIB6|uniprotkb:Q9UQ11|uniprotkb:Q9Y6E4|uniprotkb:A6NJC6|ensembl:ENSP00000444596	intact:EBI-1047158|ensembl:ENSP00000374205|uniprotkb:Q14DC5|uniprotkb:Q53TH0|uniprotkb:B2R6G5|uniprotkb:Q56A81|uniprotkb:B0AZS4	psi-mi:mycb2_human(display_long)|uniprotkb:MYCBP2(gene name)|psi-mi:MYCBP2(display_short)|uniprotkb:KIAA0916(gene name synonym)|uniprotkb:PAM(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)	psi-mi:tbr1_human(display_long)|uniprotkb:TES-56(gene name synonym)|uniprotkb:TBR1(gene name)|psi-mi:TBR1(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513254|imex:IM-28561-1039	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055872.4|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003646(Bacterial SH3-like region)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR012983(PHR)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR038648|mint:O75592|rcsb pdb:5O6C|rcsb pdb:6T7F|ensembl:ENSG00000005810(gene)|ensembl:ENST00000544440(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|dip:DIP-28142N	refseq:NP_006584.1|ensembl:ENSG00000136535(gene)|ensembl:ENST00000389554(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1902667"(regulation of axon guidance)|go:"GO:0001708"(cell fate specification)|go:"GO:0001947"(heart looping)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007420"(brain development)|go:"GO:0010092"(specification of animal organ identity)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021764"(amygdala development)|go:"GO:0021902"(commitment of neuronal cell to specific neuron type in forebrain)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030902"(hindbrain development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR001699(Transcription factor, T-box)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR018186|interpro:IPR032385|interpro:IPR036960|mint:Q16650	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:AR3FR/zd48HkVinEfdT17ItGkbU9606	rogid:qD1euHkX/welvC2klFM95IiAiWE9606	rigid:SICZcCTKkC8Fwc0b8QiyJz6YqYg	false	sufficient binding region:1-494	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O75592	uniprotkb:Q66K14	intact:EBI-1043774|uniprotkb:Q5JSX8|uniprotkb:Q5VZN6|uniprotkb:Q6PIB6|uniprotkb:Q9UQ11|uniprotkb:Q9Y6E4|uniprotkb:A6NJC6|ensembl:ENSP00000444596	intact:EBI-2688824|uniprotkb:O75163|uniprotkb:D3DWQ6|uniprotkb:Q96H49|uniprotkb:Q6MZI2|uniprotkb:Q53EY0|uniprotkb:D3DWQ5|ensembl:ENSP00000349291|ensembl:ENSP00000491373|ensembl:ENSP00000491970	psi-mi:mycb2_human(display_long)|uniprotkb:MYCBP2(gene name)|psi-mi:MYCBP2(display_short)|uniprotkb:KIAA0916(gene name synonym)|uniprotkb:PAM(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)	psi-mi:tbc9b_human(display_long)|uniprotkb:KIAA0676(gene name synonym)|uniprotkb:TBC1D9B(gene name)|psi-mi:TBC1D9B(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513245|imex:IM-28561-1037	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055872.4|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003646(Bacterial SH3-like region)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR012983(PHR)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR038648|mint:O75592|rcsb pdb:5O6C|rcsb pdb:6T7F|ensembl:ENSG00000005810(gene)|ensembl:ENST00000544440(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|dip:DIP-28142N	refseq:NP_055858.2|refseq:NP_942568.2|ensembl:ENSG00000197226(gene)|ensembl:ENSG00000284400(gene)|ensembl:ENST00000356834(transcript)|ensembl:ENST00000639361(transcript)|ensembl:ENST00000639711(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR000195(RabGAP/TBC)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR004182(GRAM)|interpro:IPR011992(EF-Hand type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035969|interpro:IPR036014|interpro:IPR036017|mint:Q66K14	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:AR3FR/zd48HkVinEfdT17ItGkbU9606	rogid:DdCLCQa69pLYH6eIKdazflUwAKY9606	rigid:XgGCLjQG+cdyLVgnujEGAYa4L9E	false	sufficient binding region:2540-3006	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O75592	uniprotkb:Q14515	intact:EBI-1043774|uniprotkb:Q5JSX8|uniprotkb:Q5VZN6|uniprotkb:Q6PIB6|uniprotkb:Q9UQ11|uniprotkb:Q9Y6E4|uniprotkb:A6NJC6|ensembl:ENSP00000444596	intact:EBI-2682673|uniprotkb:B4E2Z0|uniprotkb:E7ESU2|uniprotkb:Q14800|ensembl:ENSP00000282470|ensembl:ENSP00000414856	psi-mi:mycb2_human(display_long)|uniprotkb:MYCBP2(gene name)|psi-mi:MYCBP2(display_short)|uniprotkb:KIAA0916(gene name synonym)|uniprotkb:PAM(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym)	psi-mi:sprl1_human(display_long)|uniprotkb:High endothelial venule protein(gene name synonym)|uniprotkb:MAST 9(gene name synonym)|uniprotkb:SPARCL1(gene name)|psi-mi:SPARCL1(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513218|imex:IM-28561-1713	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055872.4|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003646(Bacterial SH3-like region)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR012983(PHR)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR038648|mint:O75592|rcsb pdb:5O6C|rcsb pdb:6T7F|ensembl:ENSG00000005810(gene)|ensembl:ENST00000544440(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|dip:DIP-28142N	refseq:NP_001278905.1|refseq:NP_001278906.1|refseq:NP_001121782.1|refseq:NP_004675.3|ensembl:ENSG00000152583(gene)|ensembl:ENST00000282470(transcript)|ensembl:ENST00000418378(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0007165"(signal transduction)|go:"GO:0048856"(anatomical structure development)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099560"(synaptic membrane adhesion)|interpro:IPR001999(Osteonectin-like, conserved site)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR003645(Follistatin-like, N-terminal)|interpro:IPR011992(EF-Hand type)|interpro:IPR015369(Follistatin)|interpro:IPR016359(SPARC-like protein 1)|interpro:IPR018247|interpro:IPR019577|interpro:IPR036058|mint:Q14515|reactome:R-HSA-381426|reactome:R-HSA-8957275	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:AR3FR/zd48HkVinEfdT17ItGkbU9606	rogid:0HWQK3GxsY5R4UiaTQdwJKFKo509606	rigid:MQ2LgBNz63JD8s9BybZ8g7AiMKQ	false	sufficient binding region:2540-3006	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q7Z417	uniprotkb:O15162	intact:EBI-1210753|intact:EBI-10172018|uniprotkb:A1L3A7|uniprotkb:Q9P2M5|uniprotkb:A1L3A6|ensembl:ENSP00000225388	intact:EBI-740019|ensembl:ENSP00000345494|uniprotkb:B2R8H8|uniprotkb:B4DTE8	psi-mi:nufp2_human(display_long)|uniprotkb:NUFIP2(gene name)|psi-mi:NUFIP2(display_short)|uniprotkb:KIAA1321(gene name synonym)|uniprotkb:PIG1(orf name)|uniprotkb:FMRP-interacting protein 2(gene name synonym)|uniprotkb:82 kDa FMRP-interacting protein(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 1 protein(gene name synonym)	psi-mi:pls1_human(display_long)|uniprotkb:PLSCR1(gene name)|psi-mi:PLSCR1(display_short)|uniprotkb:"Ca(2+)-dependent phospholipid scramblase 1"(gene name synonym)|uniprotkb:Erythrocyte phospholipid scramblase(gene name synonym)|uniprotkb:MmTRA1b(gene name synonym)|uniprotkb:"Mg(2+)-dependent nuclease"(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513560|imex:IM-28561-803	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_065823.1|dip:DIP-29023N|ensembl:ENSG00000108256(gene)|ensembl:ENST00000225388(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0042788"(polysomal ribosome)|interpro:IPR032747|mint:Q7Z417	ensembl:ENSG00000188313(gene)|ensembl:ENST00000342435(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001618"(virus receptor activity)|go:"GO:0003677"(DNA binding)|go:"GO:0004518"(nuclease activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006659"(phosphatidylserine biosynthetic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006953"(acute-phase response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010288"(response to lead ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0017121"(plasma membrane phospholipid scrambling)|go:"GO:0017124"(SH3 domain binding)|ensembl:ENSP00000345494|ensembl:ENST00000448787|ensembl:ENSP00000411675|refseq:NP_066928.1|go:"GO:0017128"(phospholipid scramblase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030168"(platelet activation)|go:"GO:0032791"(lead ion binding)|go:"GO:0033003"(regulation of mast cell activation)|go:"GO:0035456"(response to interferon-beta)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045340"(mercury ion binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0051607"(defense response to virus)|go:"GO:0060368"(regulation of Fc receptor mediated stimulatory signaling pathway)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070782"(phosphatidylserine exposure on apoptotic cell surface)|go:"GO:1905820"(positive regulation of chromosome separation)|go:"GO:2000373"("positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity")|interpro:IPR005552(Scramblase)|mint:O15162|rcsb pdb:1Y2A|refseq:XP_011511209.1|refseq:XP_011511206.1|refseq:XP_005247595.1|refseq:XP_011511208.1|refseq:XP_016862118.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:zdbkRisveP+8g70umfbEPHTnAgk9606	rogid:XudfvUkrZbB28t9tpFkokgnDFGc9606	rigid:h4Fz3CauEiXBzOOkZUnpIVjTW4M	false	sufficient binding region:1-340	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9NZ94	uniprotkb:O75128	intact:EBI-3920184|uniprotkb:Q9NZ95|uniprotkb:Q9NZ96|uniprotkb:D3DVV0|uniprotkb:Q9NZ97|uniprotkb:Q9P248|uniprotkb:Q8NCD0|ensembl:ENSP00000351591|uniprotkb:D3DVV1|uniprotkb:B2RBK1|uniprotkb:D2X2H6|uniprotkb:Q86V51	intact:EBI-3446582|uniprotkb:A4D257|uniprotkb:B7ZLW9|uniprotkb:B9EGF8|uniprotkb:Q8TCM1|uniprotkb:Q8N304|uniprotkb:A7E2B0|uniprotkb:Q86XA7|uniprotkb:Q504Y4|uniprotkb:Q2T9J3|intact:EBI-28974386|ensembl:ENSP00000265136	psi-mi:nlgn3_human(display_long)|uniprotkb:NLGN3(gene name)|psi-mi:NLGN3(display_short)|uniprotkb:KIAA1480(gene name synonym)|uniprotkb:NL3(gene name synonym)|uniprotkb:Gliotactin homolog(gene name synonym)	psi-mi:cobl_human(display_long)|uniprotkb:COBL(gene name)|psi-mi:COBL(display_short)|uniprotkb:KIAA0633(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513317|imex:IM-28561-1249	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0098793"(presynapse)|refseq:NP_001160132.1|refseq:NP_061850.2|refseq:NP_851820.1|ensembl:ENSG00000196338(gene)|ensembl:ENST00000358741(transcript)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0009986"(cell surface)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030534"(adult behavior)|go:"GO:0035176"(social behavior)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0045202"(synapse)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048675"(axon extension)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050808"(synapse organization)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060024"(rhythmic synaptic transmission)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0071625"(vocalization behavior)|go:"GO:0089717"(spanning component of membrane)|go:"GO:0097104"(postsynaptic membrane assembly)|go:"GO:0097105"(presynaptic membrane assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098985"(asymmetric, glutamatergic, excitatory synapse)|go:"GO:0099054"(presynapse assembly)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR000460(Neuroligin)|interpro:IPR002018(Carboxylesterase, type B)|interpro:IPR019819|interpro:IPR029058|interpro:IPR030024|mint:Q9NZ94|reactome:R-HSA-6794361|go:"GO:0098983"(symmetric, GABA-ergic, inhibitory synapse)|refseq:NP_001308205.1	ensembl:ENSP00000265136|ensembl:ENST00000395540|ensembl:ENSP00000378910|ensembl:ENST00000395542|ensembl:ENSP00000378912|ensembl:ENST00000441453|ensembl:ENSP00000399500|refseq:XP_011513537.1|refseq:NP_056013.2|refseq:NP_001274365.1|refseq:NP_001274367.1|refseq:NP_001333370.1|refseq:NP_001333371.1|refseq:NP_001333372.1|refseq:NP_001333373.1|ensembl:ENSG00000106078(gene)|ensembl:ENST00000265136(transcript)|go:"GO:0000578"(embryonic axis specification)|go:"GO:0001726"(ruffle)|go:"GO:0001757"(somite specification)|go:"GO:0001843"(neural tube closure)|go:"GO:0001889"(liver development)|go:"GO:0003785"(actin monomer binding)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0016020"(membrane)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030903"(notochord development)|go:"GO:0033504"(floor plate development)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048565"(digestive tract development)|go:"GO:0048669"(collateral sprouting in absence of injury)|go:"GO:0051639"(actin filament network formation)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1990357"(terminal web)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR019025|interpro:IPR039895|mint:O75128|rcsb pdb:4PL8	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:OzGAr78JAaopeMCBpHnhVXP5DaU9606	rogid:mkEX2B5sVoK8CD6RWVVCp912otg9606	rigid:xtiKc4JuCYMdqKR03bMCc7c8NwE	false	sufficient binding region:712-848	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q7Z417	uniprotkb:Q9UM47	intact:EBI-1210753|intact:EBI-10172018|uniprotkb:A1L3A7|uniprotkb:Q9P2M5|uniprotkb:A1L3A6|ensembl:ENSP00000225388	intact:EBI-1236377|uniprotkb:Q9UEB3|uniprotkb:Q9UPL3|uniprotkb:Q9Y6L8|ensembl:ENSP00000263388	psi-mi:nufp2_human(display_long)|uniprotkb:NUFIP2(gene name)|psi-mi:NUFIP2(display_short)|uniprotkb:KIAA1321(gene name synonym)|uniprotkb:PIG1(orf name)|uniprotkb:FMRP-interacting protein 2(gene name synonym)|uniprotkb:82 kDa FMRP-interacting protein(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 1 protein(gene name synonym)	psi-mi:notc3_human(display_long)|uniprotkb:NOTCH3(gene name)|psi-mi:NOTCH3(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513542|imex:IM-28561-1047	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_065823.1|dip:DIP-29023N|ensembl:ENSG00000108256(gene)|ensembl:ENST00000225388(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0042788"(polysomal ribosome)|interpro:IPR032747|mint:Q7Z417	refseq:NP_000426.2|ensembl:ENSP00000263388|dip:DIP-39827N|ensembl:ENSG00000074181(gene)|ensembl:ENST00000263388(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0009986"(cell surface)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043235"(receptor complex)|go:"GO:0045296"(cadherin binding)|go:"GO:0050793"(regulation of developmental process)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000800(Notch region)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002110(Ankyrin)|interpro:IPR008297(Notch)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR010660(Notch, NOD region)|interpro:IPR011656(Notch, NODP region)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR018097|interpro:IPR020683|interpro:IPR022331|interpro:IPR024600|interpro:IPR035993|interpro:IPR036770|mint:Q9UM47|rcsb pdb:4ZLP|rcsb pdb:5CZV|rcsb pdb:5CZX|rcsb pdb:6WQU|reactome:R-HSA-1912399|reactome:R-HSA-1912408|reactome:R-HSA-1912420|reactome:R-HSA-350054|reactome:R-HSA-5083630|reactome:R-HSA-9013507|reactome:R-HSA-9013508|reactome:R-HSA-9017802	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:zdbkRisveP+8g70umfbEPHTnAgk9606	rogid:hOarWT2DBhNVF6AhV/z+NqLCEv49606	rigid:Gtbb8VFyIIzG156/UtpKnQ8grFo	false	sufficient binding region:1-340	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q7Z417	uniprotkb:Q7Z3S9	intact:EBI-1210753|intact:EBI-10172018|uniprotkb:A1L3A7|uniprotkb:Q9P2M5|uniprotkb:A1L3A6|ensembl:ENSP00000225388	intact:EBI-945833|intact:EBI-2859688|uniprotkb:Q5BKT8|uniprotkb:Q5VTG9|uniprotkb:Q5XG84|uniprotkb:Q6P192|uniprotkb:Q8NC23|uniprotkb:Q8WUQ9|uniprotkb:Q96FY1|ensembl:ENSP00000354929	psi-mi:nufp2_human(display_long)|uniprotkb:NUFIP2(gene name)|psi-mi:NUFIP2(display_short)|uniprotkb:KIAA1321(gene name synonym)|uniprotkb:PIG1(orf name)|uniprotkb:FMRP-interacting protein 2(gene name synonym)|uniprotkb:82 kDa FMRP-interacting protein(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 1 protein(gene name synonym)	psi-mi:nt2na_human(display_long)|uniprotkb:NOTCH2NLA(gene name)|psi-mi:NOTCH2NLA(display_short)|uniprotkb:N2N(gene name synonym)|uniprotkb:NOTCH2NL(gene name synonym)|uniprotkb:Notch homolog 2 N-terminal-like protein(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513533|imex:IM-28561-599	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_065823.1|dip:DIP-29023N|ensembl:ENSG00000108256(gene)|ensembl:ENST00000225388(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0042788"(polysomal ribosome)|interpro:IPR032747|mint:Q7Z417	refseq:NP_982283.2|refseq:XP_016855384.1|refseq:XP_016855385.1|refseq:XP_016855386.1|refseq:XP_016855387.1|refseq:XP_016858537.1|refseq:XP_016858538.1|refseq:XP_016858539.1|refseq:XP_016858540.1|dip:DIP-47315N|refseq:XP_006711766.1|refseq:XP_006726418.1|ensembl:ENSG00000264343(gene)|ensembl:ENST00000362074(transcript)|go:"GO:0005112"(Notch binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030154"(cell differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR018097|mint:Q7Z3S9	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:zdbkRisveP+8g70umfbEPHTnAgk9606	rogid:FYOai/KkVz8zMsxjNnyZ6FNfcTU9606	rigid:5kpMpQUYlvaIKv9JUozWFqrr6Gk	false	sufficient binding region:1-340	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q7Z417	uniprotkb:Q99435	intact:EBI-1210753|intact:EBI-10172018|uniprotkb:A1L3A7|uniprotkb:Q9P2M5|uniprotkb:A1L3A6|ensembl:ENSP00000225388	intact:EBI-946274|intact:EBI-2845314|uniprotkb:B7Z2U7|uniprotkb:B7Z5Q4|uniprotkb:B7Z9J5|uniprotkb:B7Z9U3|uniprotkb:Q96JS2|ensembl:ENSP00000390680|ensembl:ENSP00000394612	psi-mi:nufp2_human(display_long)|uniprotkb:NUFIP2(gene name)|psi-mi:NUFIP2(display_short)|uniprotkb:KIAA1321(gene name synonym)|uniprotkb:PIG1(orf name)|uniprotkb:FMRP-interacting protein 2(gene name synonym)|uniprotkb:82 kDa FMRP-interacting protein(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 1 protein(gene name synonym)	psi-mi:nell2_human(display_long)|uniprotkb:NELL2(gene name)|psi-mi:NELL2(display_short)|uniprotkb:NRP2(gene name synonym)|uniprotkb:NEL-like protein 2(gene name synonym)|uniprotkb:Nel-related protein 2(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513524|imex:IM-28561-597	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_065823.1|dip:DIP-29023N|ensembl:ENSG00000108256(gene)|ensembl:ENST00000225388(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0042788"(polysomal ribosome)|interpro:IPR032747|mint:Q7Z417	refseq:NP_001138579.1|refseq:NP_001138580.1|refseq:NP_001138581.1|refseq:NP_001138582.1|refseq:NP_006150.1|refseq:XP_011536698.1|refseq:XP_005268962.1|dip:DIP-49927N|ensembl:ENSG00000184613(gene)|ensembl:ENST00000429094(transcript)|ensembl:ENST00000452445(transcript)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0008201"(heparin binding)|go:"GO:0070050"(neuron cellular homeostasis)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR001791(Laminin G)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR018097|mint:Q99435|rcsb pdb:6POG|reactome:R-HSA-428542	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:zdbkRisveP+8g70umfbEPHTnAgk9606	rogid:/NYlmX9iC3H17WXd+u97CVwOD7c9606	rigid:SI6/WtmUISWMItydzdBz+wSeAhU	false	sufficient binding region:1-340	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q7Z417	uniprotkb:Q92832	intact:EBI-1210753|intact:EBI-10172018|uniprotkb:A1L3A7|uniprotkb:Q9P2M5|uniprotkb:A1L3A6|ensembl:ENSP00000225388	intact:EBI-947754|uniprotkb:Q4VB91|uniprotkb:Q4VB90|uniprotkb:B2CKC1|uniprotkb:Q9Y472|uniprotkb:Q6NSY8|ensembl:ENSP00000349654	psi-mi:nufp2_human(display_long)|uniprotkb:NUFIP2(gene name)|psi-mi:NUFIP2(display_short)|uniprotkb:KIAA1321(gene name synonym)|uniprotkb:PIG1(orf name)|uniprotkb:FMRP-interacting protein 2(gene name synonym)|uniprotkb:82 kDa FMRP-interacting protein(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 1 protein(gene name synonym)	psi-mi:nell1_human(display_long)|uniprotkb:NEL-like protein 1(gene name synonym)|uniprotkb:Nel-related protein 1(gene name synonym)|uniprotkb:NELL1(gene name)|psi-mi:NELL1(display_short)|uniprotkb:NRP1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513515|imex:IM-28561-155	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_065823.1|dip:DIP-29023N|ensembl:ENSG00000108256(gene)|ensembl:ENST00000225388(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0042788"(polysomal ribosome)|interpro:IPR032747|mint:Q7Z417	refseq:NP_006148.2|refseq:NP_963845.1|refseq:NP_001275642.1|refseq:NP_001275643.1|ensembl:ENSG00000165973(gene)|ensembl:ENST00000357134(transcript)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0007399"(nervous system development)|go:"GO:0008201"(heparin binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0030154"(cell differentiation)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0033689"(negative regulation of osteoblast proliferation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:1903363"(negative regulation of cellular protein catabolic process)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR001791(Laminin G)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR018097|interpro:IPR024731|mint:Q92832|rcsb pdb:6POL	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:zdbkRisveP+8g70umfbEPHTnAgk9606	rogid:nC7vtd2PeL7K7QjSVJDoDJE3owk9606	rigid:Or8okwxQxF30KFE0VB8QSdP6tek	false	sufficient binding region:1-340	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q7Z417	uniprotkb:Q9NRX3	intact:EBI-1210753|intact:EBI-10172018|uniprotkb:A1L3A7|uniprotkb:Q9P2M5|uniprotkb:A1L3A6|ensembl:ENSP00000225388	intact:EBI-713480|uniprotkb:Q6IAH9|ensembl:ENSP00000377411|ensembl:ENSP00000450664	psi-mi:nufp2_human(display_long)|uniprotkb:NUFIP2(gene name)|psi-mi:NUFIP2(display_short)|uniprotkb:KIAA1321(gene name synonym)|uniprotkb:PIG1(orf name)|uniprotkb:FMRP-interacting protein 2(gene name synonym)|uniprotkb:82 kDa FMRP-interacting protein(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 1 protein(gene name synonym)	psi-mi:nua4l_human(display_long)|uniprotkb:NADH-ubiquinone oxidoreductase MLRQ subunit homolog(gene name synonym)|uniprotkb:NDUFA4L2(gene name)|psi-mi:NDUFA4L2(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513506|imex:IM-28561-1255	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_065823.1|dip:DIP-29023N|ensembl:ENSG00000108256(gene)|ensembl:ENST00000225388(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0042788"(polysomal ribosome)|interpro:IPR032747|mint:Q7Z417	go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0022900"(electron transport chain)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR010530(B12D)|mint:Q9NRX3|ensembl:ENSG00000185633(gene)|ensembl:ENST00000393825(transcript)|ensembl:ENST00000554503(transcript)|refseq:NP_064527.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:zdbkRisveP+8g70umfbEPHTnAgk9606	rogid:FOFWULqUtDH3x5iyCYnV1TwPulo9606	rigid:L8fGPpaB1hoMzLtjL2n0XDcUUrA	false	sufficient binding region:1-340	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q7Z417	uniprotkb:O75095	intact:EBI-1210753|intact:EBI-10172018|uniprotkb:A1L3A7|uniprotkb:Q9P2M5|uniprotkb:A1L3A6|ensembl:ENSP00000225388	intact:EBI-947597|uniprotkb:Q5VV39|uniprotkb:Q4AC86|ensembl:ENSP00000348982	psi-mi:nufp2_human(display_long)|uniprotkb:NUFIP2(gene name)|psi-mi:NUFIP2(display_short)|uniprotkb:KIAA1321(gene name synonym)|uniprotkb:PIG1(orf name)|uniprotkb:FMRP-interacting protein 2(gene name synonym)|uniprotkb:82 kDa FMRP-interacting protein(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 1 protein(gene name synonym)	psi-mi:megf6_human(display_long)|uniprotkb:MEGF6(gene name)|psi-mi:MEGF6(display_short)|uniprotkb:EGFL3(gene name synonym)|uniprotkb:KIAA0815(gene name synonym)|uniprotkb:Epidermal growth factor-like protein 3(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513497|imex:IM-28561-373	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_065823.1|dip:DIP-29023N|ensembl:ENSG00000108256(gene)|ensembl:ENST00000225388(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0042788"(polysomal ribosome)|interpro:IPR032747|mint:Q7Z417	refseq:NP_001400.3|ensembl:ENSG00000162591(gene)|ensembl:ENST00000356575(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002049(EGF-like, laminin)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011489(EMI)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR018097|mint:O75095	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:zdbkRisveP+8g70umfbEPHTnAgk9606	rogid:/4HcLiv4UEW2qmvoV2OTj110y1I9606	rigid:hrAjARUYfhJvqka82L+KbYhpg8E	false	sufficient binding region:1-340	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q7Z417	uniprotkb:Q8N2S1	intact:EBI-1210753|intact:EBI-10172018|uniprotkb:A1L3A7|uniprotkb:Q9P2M5|uniprotkb:A1L3A6|ensembl:ENSP00000225388	intact:EBI-947718|uniprotkb:O75412|uniprotkb:O75413|uniprotkb:O00508|ensembl:ENSP00000311905	psi-mi:nufp2_human(display_long)|uniprotkb:NUFIP2(gene name)|psi-mi:NUFIP2(display_short)|uniprotkb:KIAA1321(gene name synonym)|uniprotkb:PIG1(orf name)|uniprotkb:FMRP-interacting protein 2(gene name synonym)|uniprotkb:82 kDa FMRP-interacting protein(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 1 protein(gene name synonym)	psi-mi:ltbp4_human(display_long)|uniprotkb:LTBP4(gene name)|psi-mi:LTBP4(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513488|imex:IM-28561-1045	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_065823.1|dip:DIP-29023N|ensembl:ENSG00000108256(gene)|ensembl:ENST00000225388(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0042788"(polysomal ribosome)|interpro:IPR032747|mint:Q7Z417	refseq:NP_001036009.1|refseq:NP_001036010.1|refseq:NP_003564.2|ensembl:ENSG00000090006(gene)|ensembl:ENST00000308370(transcript)|go:"GO:0001527"(microfibril)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006457"(protein folding)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007275"(multicellular organism development)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0030252"(growth hormone secretion)|go:"GO:0031012"(extracellular matrix)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0048251"(elastic fiber assembly)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR017878|interpro:IPR018097|interpro:IPR036773|mint:Q8N2S1|reactome:R-HSA-2129379	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:zdbkRisveP+8g70umfbEPHTnAgk9606	rogid:mBWo9asZp3rjkytgvTD+7OE5K5I9606	rigid:Hs+QFfIfYwdllPyrJfDhdXQVOew	false	sufficient binding region:1-340	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q7Z417	uniprotkb:Q9NS15	intact:EBI-1210753|intact:EBI-10172018|uniprotkb:A1L3A7|uniprotkb:Q9P2M5|uniprotkb:A1L3A6|ensembl:ENSP00000225388	intact:EBI-3927098|uniprotkb:Q9H7K2|uniprotkb:Q96HB9|uniprotkb:Q9UFN4|uniprotkb:O15107|ensembl:ENSP00000301873	psi-mi:nufp2_human(display_long)|uniprotkb:NUFIP2(gene name)|psi-mi:NUFIP2(display_short)|uniprotkb:KIAA1321(gene name synonym)|uniprotkb:PIG1(orf name)|uniprotkb:FMRP-interacting protein 2(gene name synonym)|uniprotkb:82 kDa FMRP-interacting protein(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 1 protein(gene name synonym)	psi-mi:ltbp3_human(display_long)|uniprotkb:LTBP3(gene name)|psi-mi:LTBP3(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513479|imex:IM-28561-371	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_065823.1|dip:DIP-29023N|ensembl:ENSG00000108256(gene)|ensembl:ENST00000225388(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0042788"(polysomal ribosome)|interpro:IPR032747|mint:Q7Z417	refseq:NP_001123616.1|refseq:NP_001157738.1|refseq:NP_066548.2|go:"GO:0036363"(transforming growth factor beta activation)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0046849"(bone remodeling)|go:"GO:0048251"(elastic fiber assembly)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0060430"(lung saccule development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:1902462"(positive regulation of mesenchymal stem cell proliferation)|go:"GO:2000741"(positive regulation of mesenchymal stem cell differentiation)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR017878|interpro:IPR018097|interpro:IPR026823|interpro:IPR036773|mint:Q9NS15|reactome:R-HSA-2129379|ensembl:ENSG00000168056(gene)|ensembl:ENST00000301873(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:zdbkRisveP+8g70umfbEPHTnAgk9606	rogid:wTlw1eFDbHiWYm9/2sgGxqK1uI49606	rigid:R8BTozbCjjnXzenfjLzahCUMmks	false	sufficient binding region:1-340	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q7Z417	uniprotkb:P07910	intact:EBI-1210753|intact:EBI-10172018|uniprotkb:A1L3A7|uniprotkb:Q9P2M5|uniprotkb:A1L3A6|ensembl:ENSP00000225388	intact:EBI-357966|uniprotkb:P22628|uniprotkb:Q53EX2|uniprotkb:Q59FD3|uniprotkb:Q5FWE8|uniprotkb:Q86SF8|uniprotkb:Q86U45|uniprotkb:Q96HK7|uniprotkb:Q96HM4|uniprotkb:Q96IY5|uniprotkb:Q9BTS3|uniprotkb:D3DS19|uniprotkb:D3DS22|intact:EBI-28976506|ensembl:ENSP00000404848|ensembl:ENSP00000451291|ensembl:ENSP00000452276	psi-mi:nufp2_human(display_long)|uniprotkb:NUFIP2(gene name)|psi-mi:NUFIP2(display_short)|uniprotkb:KIAA1321(gene name synonym)|uniprotkb:PIG1(orf name)|uniprotkb:FMRP-interacting protein 2(gene name synonym)|uniprotkb:82 kDa FMRP-interacting protein(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 1 protein(gene name synonym)	psi-mi:hnrpc_human(display_long)|uniprotkb:HNRNPC(gene name)|psi-mi:HNRNPC(display_short)|uniprotkb:HNRPC(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513470|imex:IM-28561-369	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_065823.1|dip:DIP-29023N|ensembl:ENSG00000108256(gene)|ensembl:ENST00000225388(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0042788"(polysomal ribosome)|interpro:IPR032747|mint:Q7Z417	refseq:NP_001070910.1|refseq:NP_001070911.1|refseq:NP_004491.2|refseq:NP_112604.2|ensembl:ENSP00000404848|ensembl:ENST00000430246|ensembl:ENSP00000442816|ensembl:ENST00000553300|ensembl:ENSP00000450544|ensembl:ENSP00000451291|ensembl:ENST00000554969|ensembl:ENSP00000452276|ensembl:ENSP00000450725|ensembl:ENST00000555883|ensembl:ENSP00000450629|ensembl:ENST00000556628|ensembl:ENSP00000451652|ensembl:ENST00000556897|ensembl:ENSP00000451176|refseq:XP_011535010.1|refseq:XP_011535011.1|refseq:XP_011535012.1|refseq:XP_011535013.1|refseq:XP_011535014.1|refseq:XP_016876741.1|refseq:XP_016876742.1|dip:DIP-29854N|refseq:XP_006720188.1|ensembl:ENSG00000092199(gene)|ensembl:ENST00000420743(transcript)|ensembl:ENST00000554455(transcript)|ensembl:ENST00000557201(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000785"(chromatin)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0031492"(nucleosomal DNA binding)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043044"|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1990247"(N6-methyladenosine-containing RNA binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR017347(Heterogeneous nuclear ribonucleoprotein C, Raly)|interpro:IPR035979|mint:P07910|rcsb pdb:1TXP|rcsb pdb:1WF2|rcsb pdb:2MXY|rcsb pdb:2MZ1|rcsb pdb:3LN4|reactome:R-HSA-4570464|reactome:R-HSA-72163|reactome:R-HSA-72203|reactome:R-HSA-9013418|reactome:R-HSA-9013422	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:zdbkRisveP+8g70umfbEPHTnAgk9606	rogid:Fj5tiH0wrNUjTnsURIg8dB8laMg9606	rigid:8mP2dYtw69Ppy44f3CVZKkYMI2A	false	sufficient binding region:1-340	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q7Z417	uniprotkb:P28799	intact:EBI-1210753|intact:EBI-10172018|uniprotkb:A1L3A7|uniprotkb:Q9P2M5|uniprotkb:A1L3A6|ensembl:ENSP00000225388	intact:EBI-747754|uniprotkb:P23781|uniprotkb:P23782|uniprotkb:P23783|uniprotkb:P23784|uniprotkb:Q9BWE7|uniprotkb:Q9UCH0|ensembl:ENSP00000053867|uniprotkb:Q53Y88|uniprotkb:Q540U8|uniprotkb:D3DX55|uniprotkb:Q53HQ8|uniprotkb:Q9H8S1	psi-mi:nufp2_human(display_long)|uniprotkb:NUFIP2(gene name)|psi-mi:NUFIP2(display_short)|uniprotkb:KIAA1321(gene name synonym)|uniprotkb:PIG1(orf name)|uniprotkb:FMRP-interacting protein 2(gene name synonym)|uniprotkb:82 kDa FMRP-interacting protein(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 1 protein(gene name synonym)	psi-mi:grn_human(display_long)|uniprotkb:Proepithelin(gene name synonym)|uniprotkb:GRN(gene name)|psi-mi:GRN(display_short)|uniprotkb:Acrogranin(gene name synonym)|uniprotkb:Epithelin precursor(gene name synonym)|uniprotkb:Glycoprotein of 88 Kda(gene name synonym)|uniprotkb:Granulin precursor(gene name synonym)|uniprotkb:PC cell-derived growth factor(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513461|imex:IM-28561-1721	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_065823.1|dip:DIP-29023N|ensembl:ENSG00000108256(gene)|ensembl:ENST00000225388(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0042788"(polysomal ribosome)|interpro:IPR032747|mint:Q7Z417	refseq:NP_002078.1|ensembl:ENSG00000030582(gene)|ensembl:ENST00000053867(transcript)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0003723"(RNA binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007040"(lysosome organization)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048680"(positive regulation of axon regeneration)|refseq:XP_005257310.1|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0060266"(negative regulation of respiratory burst involved in inflammatory response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0106016"(positive regulation of inflammatory response to wounding)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1902564"(negative regulation of neutrophil activation)|go:"GO:1903334"(positive regulation of protein folding)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1905247"(positive regulation of aspartic-type peptidase activity)|go:"GO:1905673"(positive regulation of lysosome organization)|interpro:IPR000118(Granulin)|interpro:IPR037277|interpro:IPR039036|mint:P28799|rcsb pdb:1G26|rcsb pdb:2JYE|rcsb pdb:2JYT|rcsb pdb:2JYU|rcsb pdb:2JYV|rcsb pdb:6NUG|reactome:R-HSA-6798695|dip:DIP-41742N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:zdbkRisveP+8g70umfbEPHTnAgk9606	rogid:SaujQCj7wHfPYunGzgTgG+jQgA89606	rigid:dZdsGRJ5rda2huoJTH1eZJTzK6k	false	sufficient binding region:1-340	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q7Z417	uniprotkb:P04406	intact:EBI-1210753|intact:EBI-10172018|uniprotkb:A1L3A7|uniprotkb:Q9P2M5|uniprotkb:A1L3A6|ensembl:ENSP00000225388	intact:EBI-354056|uniprotkb:P00354|uniprotkb:Q53X65|uniprotkb:E7EUT4|ensembl:ENSP00000229239|ensembl:ENSP00000380068|ensembl:ENSP00000380070	psi-mi:nufp2_human(display_long)|uniprotkb:NUFIP2(gene name)|psi-mi:NUFIP2(display_short)|uniprotkb:KIAA1321(gene name synonym)|uniprotkb:PIG1(orf name)|uniprotkb:FMRP-interacting protein 2(gene name synonym)|uniprotkb:82 kDa FMRP-interacting protein(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 1 protein(gene name synonym)	psi-mi:g3p_human(display_long)|uniprotkb:GAPDH(gene name)|psi-mi:GAPDH(display_short)|uniprotkb:OK/SW-cl.12(orf name)|uniprotkb:CDABP0047(orf name)|uniprotkb:GAPD(gene name synonym)|uniprotkb:Peptidyl-cysteine S-nitrosylase GAPDH(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513452|imex:IM-28561-801	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_065823.1|dip:DIP-29023N|ensembl:ENSG00000108256(gene)|ensembl:ENST00000225388(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0042788"(polysomal ribosome)|interpro:IPR032747|mint:Q7Z417	refseq:NP_002037.2|refseq:NP_001243728.1|refseq:NP_001276674.1|refseq:NP_001276675.1|dip:DIP-32521N|go:"GO:0031965"(nuclear membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0035605"(peptidyl-cysteine S-nitrosylase activity)|go:"GO:0035606"(peptidyl-cysteine S-trans-nitrosylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050661"(NADP binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0050832"(defense response to fungus)|go:"GO:0051287"(NAD binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051873"(killing by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0097452"(GAIT complex)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR006424(Glyceraldehyde-3-phosphate dehydrogenase, type I)|interpro:IPR020828|interpro:IPR020829|interpro:IPR020830|interpro:IPR020831|interpro:IPR036291|mint:P04406|rcsb pdb:1U8F|rcsb pdb:1ZNQ|rcsb pdb:2FEH|rcsb pdb:3GPD|rcsb pdb:4WNC|rcsb pdb:4WNI|rcsb pdb:6ADE|rcsb pdb:6M61|rcsb pdb:6YND|rcsb pdb:6YNE|rcsb pdb:6YNF|rcsb pdb:6YNH|reactome:R-HSA-70171|reactome:R-HSA-70263|rcsb pdb:6IQ6|ensembl:ENSG00000111640(gene)|ensembl:ENST00000229239(transcript)|ensembl:ENST00000396859(transcript)|ensembl:ENST00000396861(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0004365"("glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0008017"(microtubule binding)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0031640"(killing of cells of another organism)	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:zdbkRisveP+8g70umfbEPHTnAgk9606	rogid:9YENN/dfKl/d0tJtfFyQp2o8eAc9606	rigid:g7yH1Huus9+pt3Q42os6skRNSxU	false	sufficient binding region:1-340	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q7Z417	uniprotkb:Q9UBX5	intact:EBI-1210753|intact:EBI-10172018|uniprotkb:A1L3A7|uniprotkb:Q9P2M5|uniprotkb:A1L3A6|ensembl:ENSP00000225388	intact:EBI-947897|uniprotkb:O75966|uniprotkb:Q6UWA3|uniprotkb:Q6IAL4|ensembl:ENSP00000345008	psi-mi:nufp2_human(display_long)|uniprotkb:NUFIP2(gene name)|psi-mi:NUFIP2(display_short)|uniprotkb:KIAA1321(gene name synonym)|uniprotkb:PIG1(orf name)|uniprotkb:FMRP-interacting protein 2(gene name synonym)|uniprotkb:82 kDa FMRP-interacting protein(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 1 protein(gene name synonym)	psi-mi:fbln5_human(display_long)|uniprotkb:Developmental arteries and neural crest EGF-like protein(gene name synonym)|uniprotkb:Urine p50 protein(gene name synonym)|uniprotkb:FBLN5(gene name)|psi-mi:FBLN5(display_short)|uniprotkb:DANCE(gene name synonym)|uniprotkb:UNQ184/PRO210(orf name)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513443|imex:IM-28561-595	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_065823.1|dip:DIP-29023N|ensembl:ENSG00000108256(gene)|ensembl:ENST00000225388(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0042788"(polysomal ribosome)|interpro:IPR032747|mint:Q7Z417	refseq:NP_006320.2|dip:DIP-44301N|ensembl:ENSG00000140092(gene)|ensembl:ENST00000342058(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046903"(secretion)|go:"GO:0048251"(elastic fiber assembly)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:2000121"(regulation of removal of superoxide radicals)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR018097|interpro:IPR026823|interpro:IPR037288|mint:Q9UBX5|reactome:R-HSA-1566948|reactome:R-HSA-2129379	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:zdbkRisveP+8g70umfbEPHTnAgk9606	rogid:1fqx+PBkfO9F1/5wXcNasL9R8Mk9606	rigid:r02XNipzVbaVszrBgcdFnJFXFXY	false	sufficient binding region:1-340	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q7Z417	uniprotkb:P98095	intact:EBI-1210753|intact:EBI-10172018|uniprotkb:A1L3A7|uniprotkb:Q9P2M5|uniprotkb:A1L3A6|ensembl:ENSP00000225388	intact:EBI-947973|uniprotkb:B7Z9C5|uniprotkb:Q8IUI0|uniprotkb:Q8IUI1|ensembl:ENSP00000295760	psi-mi:nufp2_human(display_long)|uniprotkb:NUFIP2(gene name)|psi-mi:NUFIP2(display_short)|uniprotkb:KIAA1321(gene name synonym)|uniprotkb:PIG1(orf name)|uniprotkb:FMRP-interacting protein 2(gene name synonym)|uniprotkb:82 kDa FMRP-interacting protein(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 1 protein(gene name synonym)	psi-mi:fbln2_human(display_long)|uniprotkb:FBLN2(gene name)|psi-mi:FBLN2(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513434|imex:IM-28561-1253	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_065823.1|dip:DIP-29023N|ensembl:ENSG00000108256(gene)|ensembl:ENST00000225388(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0042788"(polysomal ribosome)|interpro:IPR032747|mint:Q7Z417	refseq:NP_001004019.1|refseq:NP_001158507.1|refseq:NP_001989.2|ensembl:ENSG00000163520(gene)|ensembl:ENST00000295760(transcript)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0030023"(extracellular matrix constituent conferring elasticity)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:1903561"(extracellular vesicle)|interpro:IPR000020(Anaphylatoxin/fibulin)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR018097|interpro:IPR026823|interpro:IPR037286|mint:P98095|reactome:R-HSA-2129379	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:zdbkRisveP+8g70umfbEPHTnAgk9606	rogid:HoVQ3qvVH6GlAeeI8VEXtIwbkgY9606	rigid:RvGZrgbpfqwjXu2dBXgQuuFEpxo	false	sufficient binding region:1-340	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q7Z417	uniprotkb:P23142	intact:EBI-1210753|intact:EBI-10172018|uniprotkb:A1L3A7|uniprotkb:Q9P2M5|uniprotkb:A1L3A6|ensembl:ENSP00000225388	intact:EBI-726652|uniprotkb:P23143|uniprotkb:P23144|uniprotkb:P37888|uniprotkb:Q5TIC4|uniprotkb:Q8TBH8|uniprotkb:Q9HBQ5|uniprotkb:Q9UC21|uniprotkb:Q9UGR4|uniprotkb:Q9UH41|uniprotkb:B0QY42|intact:EBI-2562209|ensembl:ENSP00000331544|uniprotkb:B1AHL4	psi-mi:nufp2_human(display_long)|uniprotkb:NUFIP2(gene name)|psi-mi:NUFIP2(display_short)|uniprotkb:KIAA1321(gene name synonym)|uniprotkb:PIG1(orf name)|uniprotkb:FMRP-interacting protein 2(gene name synonym)|uniprotkb:82 kDa FMRP-interacting protein(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 1 protein(gene name synonym)	psi-mi:fbln1_human(display_long)|uniprotkb:FBLN1(gene name)|psi-mi:FBLN1(display_short)|uniprotkb:PP213(orf name)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513425|imex:IM-28561-367	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_065823.1|dip:DIP-29023N|ensembl:ENSG00000108256(gene)|ensembl:ENST00000225388(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0042788"(polysomal ribosome)|interpro:IPR032747|mint:Q7Z417	refseq:NP_001987.2|refseq:NP_006476.2|refseq:NP_006477.2|refseq:NP_006478.2|ensembl:ENSG00000077942(gene)|ensembl:ENST00000327858(transcript)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001968"(fibronectin binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007566"(embryo implantation)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070051"(fibrinogen binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071635"(negative regulation of transforming growth factor beta production)|go:"GO:0071953"(elastic fiber)|go:"GO:0072378"(blood coagulation, fibrin clot formation)|go:"GO:1900025"(negative regulation of substrate adhesion-dependent cell spreading)|go:"GO:1904188"(negative regulation of transformation of host cell by virus)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000647"(negative regulation of stem cell proliferation)|interpro:IPR000020(Anaphylatoxin/fibulin)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR017048(Fibulin-1)|interpro:IPR018097|interpro:IPR026823|mint:P23142|reactome:R-HSA-2129379|go:"GO:0005201"(extracellular matrix structural constituent)	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:zdbkRisveP+8g70umfbEPHTnAgk9606	rogid:a47ZJLXWeghGIY9xJTQI7VujuMk9606	rigid:7WhdUjRHG54EnbIrO0EdW7ZzEsE	false	sufficient binding region:1-340	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q7Z417	uniprotkb:Q9UHF1	intact:EBI-1210753|intact:EBI-10172018|uniprotkb:A1L3A7|uniprotkb:Q9P2M5|uniprotkb:A1L3A6|ensembl:ENSP00000225388	intact:EBI-949532|ensembl:ENSP00000307843|ensembl:ENSP00000360763|ensembl:ENSP00000360764|ensembl:ENSP00000385639|uniprotkb:Q5M7Y5|uniprotkb:Q5VUD5|uniprotkb:Q96EG0|uniprotkb:B3KRP0|uniprotkb:M9VTX9	psi-mi:nufp2_human(display_long)|uniprotkb:NUFIP2(gene name)|psi-mi:NUFIP2(display_short)|uniprotkb:KIAA1321(gene name synonym)|uniprotkb:PIG1(orf name)|uniprotkb:FMRP-interacting protein 2(gene name synonym)|uniprotkb:82 kDa FMRP-interacting protein(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 1 protein(gene name synonym)	psi-mi:egfl7_human(display_long)|uniprotkb:Multiple epidermal growth factor-like domains protein 7(gene name synonym)|uniprotkb:Zneu1(gene name synonym)|uniprotkb:Vascular endothelial statin(gene name synonym)|uniprotkb:NOTCH4-like protein(gene name synonym)|uniprotkb:EGFL7(gene name)|psi-mi:EGFL7(display_short)|uniprotkb:MEGF7(gene name synonym)|uniprotkb:UNQ187/PRO1449(orf name)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513416|imex:IM-28561-1251	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_065823.1|dip:DIP-29023N|ensembl:ENSG00000108256(gene)|ensembl:ENST00000225388(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0042788"(polysomal ribosome)|interpro:IPR032747|mint:Q7Z417	ensembl:ENSG00000172889(gene)|ensembl:ENST00000308874(transcript)|ensembl:ENST00000371698(transcript)|ensembl:ENST00000371699(transcript)|ensembl:ENST00000406555(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001568"(blood vessel development)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0007155"(cell adhesion)|go:"GO:0009986"(cell surface)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0048856"(anatomical structure development)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011489(EMI)|interpro:IPR013111(EGF, extracellular)|interpro:IPR018097|mint:Q9UHF1|go:"GO:0005576"(extracellular region)|refseq:NP_057299.1|refseq:NP_958854.1|refseq:XP_011517066.1|refseq:XP_011517067.1|refseq:XP_011517068.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:zdbkRisveP+8g70umfbEPHTnAgk9606	rogid:HzaJXQm4JE8bXXE+/ugmqGjpjZA9606	rigid:+BsKVVLTHHadi9W76ZWvcFRyG1I	false	sufficient binding region:1-340	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q7Z417	uniprotkb:Q12805	intact:EBI-1210753|intact:EBI-10172018|uniprotkb:A1L3A7|uniprotkb:Q9P2M5|uniprotkb:A1L3A6|ensembl:ENSP00000225388	intact:EBI-536772|uniprotkb:Q541U7|uniprotkb:A8K3I4|uniprotkb:D6W5D2|ensembl:ENSP00000347596|ensembl:ENSP00000378058|uniprotkb:B4DW75	psi-mi:nufp2_human(display_long)|uniprotkb:NUFIP2(gene name)|psi-mi:NUFIP2(display_short)|uniprotkb:KIAA1321(gene name synonym)|uniprotkb:PIG1(orf name)|uniprotkb:FMRP-interacting protein 2(gene name synonym)|uniprotkb:82 kDa FMRP-interacting protein(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 1 protein(gene name synonym)	psi-mi:fbln3_human(display_long)|uniprotkb:Fibulin-3(gene name synonym)|uniprotkb:Fibrillin-like protein(gene name synonym)|uniprotkb:Extracellular protein S1-5(gene name synonym)|uniprotkb:EFEMP1(gene name)|psi-mi:EFEMP1(display_short)|uniprotkb:FBLN3(gene name synonym)|uniprotkb:FBNL(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513407|imex:IM-28561-153	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_065823.1|dip:DIP-29023N|ensembl:ENSG00000108256(gene)|ensembl:ENST00000225388(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0042788"(polysomal ribosome)|interpro:IPR032747|mint:Q7Z417	ensembl:ENSG00000115380(gene)|ensembl:ENST00000355426(transcript)|ensembl:ENST00000394555(transcript)|go:"GO:0005006"(epidermal growth factor-activated receptor activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007601"(visual perception)|go:"GO:0008083"(growth factor activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0043010"(camera-type eye development)|go:"GO:0048048"(embryonic eye morphogenesis)|go:"GO:0048050"(post-embryonic eye morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR018097|interpro:IPR026823|interpro:IPR032973|mint:Q12805|reactome:R-HSA-2129379|refseq:NP_001034437.1|refseq:NP_001034438.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:zdbkRisveP+8g70umfbEPHTnAgk9606	rogid:V32dS+EEp5Syu3A6lQJal0fg6UM9606	rigid:9ZGz64xKv2WVhgr6fCS8liwP/G8	false	sufficient binding region:1-340	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q7Z417	uniprotkb:Q9UBP4	intact:EBI-1210753|intact:EBI-10172018|uniprotkb:A1L3A7|uniprotkb:Q9P2M5|uniprotkb:A1L3A6|ensembl:ENSP00000225388	intact:EBI-954409|ensembl:ENSP00000314910|ensembl:ENSP00000379762|ensembl:ENSP00000506835|uniprotkb:Q9ULB7|uniprotkb:A8K1I2|uniprotkb:D3DQW1	psi-mi:nufp2_human(display_long)|uniprotkb:NUFIP2(gene name)|psi-mi:NUFIP2(display_short)|uniprotkb:KIAA1321(gene name synonym)|uniprotkb:PIG1(orf name)|uniprotkb:FMRP-interacting protein 2(gene name synonym)|uniprotkb:82 kDa FMRP-interacting protein(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 1 protein(gene name synonym)	psi-mi:dkk3_human(display_long)|uniprotkb:REIC(gene name synonym)|uniprotkb:UNQ258/PRO295(orf name)|uniprotkb:DKK3(gene name)|psi-mi:DKK3(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513398|imex:IM-28561-1513	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_065823.1|dip:DIP-29023N|ensembl:ENSG00000108256(gene)|ensembl:ENST00000225388(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0042788"(polysomal ribosome)|interpro:IPR032747|mint:Q7Z417	ensembl:ENSG00000050165(gene)|ensembl:ENST00000326932(transcript)|ensembl:ENST00000396505(transcript)|ensembl:ENST00000683431(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030325"(adrenal gland development)|go:"GO:0032348"(negative regulation of aldosterone biosynthetic process)|go:"GO:0039706"(co-receptor binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048019"(receptor antagonist activity)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1902613"(negative regulation of anti-Mullerian hormone signaling pathway)|go:"GO:2000065"(negative regulation of cortisol biosynthetic process)|interpro:IPR006796(Dickkopf, N-terminal cysteine-rich)|interpro:IPR039863|mint:Q9UBP4|refseq:NP_001018067.1|refseq:NP_037385.2|refseq:NP_056965.3|refseq:XP_006718241.1|refseq:NP_001317149.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:zdbkRisveP+8g70umfbEPHTnAgk9606	rogid:pnbEZP5fAWw3Qxg1gB1sjP0Oyeo9606	rigid:HFKeY5OeVBJpAv7MW5IACcQ4pmk	false	sufficient binding region:1-340	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q7Z417	uniprotkb:Q96HD1	intact:EBI-1210753|intact:EBI-10172018|uniprotkb:A1L3A7|uniprotkb:Q9P2M5|uniprotkb:A1L3A6|ensembl:ENSP00000225388	intact:EBI-713009|uniprotkb:Q6I9X5|uniprotkb:Q8NFT4|uniprotkb:Q9Y409|uniprotkb:A8MX90|uniprotkb:B2RAA9|ensembl:ENSP00000373322|ensembl:ENSP00000393643|ensembl:ENSP00000507127|ensembl:ENSP00000508358	psi-mi:nufp2_human(display_long)|uniprotkb:NUFIP2(gene name)|psi-mi:NUFIP2(display_short)|uniprotkb:KIAA1321(gene name synonym)|uniprotkb:PIG1(orf name)|uniprotkb:FMRP-interacting protein 2(gene name synonym)|uniprotkb:82 kDa FMRP-interacting protein(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 1 protein(gene name synonym)	psi-mi:crel1_human(display_long)|uniprotkb:CRELD1(gene name)|psi-mi:CRELD1(display_short)|uniprotkb:CIRRIN(gene name synonym)|uniprotkb:Cysteine-rich with EGF-like domain protein 1(gene name synonym)|uniprotkb:UNQ188/PRO214(orf name)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513389|imex:IM-28561-1511	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_065823.1|dip:DIP-29023N|ensembl:ENSG00000108256(gene)|ensembl:ENST00000225388(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0042788"(polysomal ribosome)|interpro:IPR032747|mint:Q7Z417	refseq:NP_001026887.1|refseq:NP_001070883.1|refseq:NP_056328.2|refseq:XP_016862664.1|ensembl:ENSG00000163703(gene)|ensembl:ENST00000383811(transcript)|ensembl:ENST00000452070(transcript)|ensembl:ENST00000682783(transcript)|ensembl:ENST00000684493(transcript)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003279"(cardiac septum development)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002049(EGF-like, laminin)|interpro:IPR006212(Furin-like repeat)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR018097|interpro:IPR021852|mint:Q96HD1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:zdbkRisveP+8g70umfbEPHTnAgk9606	rogid:YCHTMCBYRLSWAJ4W+2lmt/EjUlQ9606	rigid:jD/tLCF/ZJl9lIA8Y9CQZth0gh0	false	sufficient binding region:1-340	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q7Z417	uniprotkb:Q9H2X0	intact:EBI-1210753|intact:EBI-10172018|uniprotkb:A1L3A7|uniprotkb:Q9P2M5|uniprotkb:A1L3A6|ensembl:ENSP00000225388	intact:EBI-947551|intact:EBI-1752274|uniprotkb:O95254|uniprotkb:Q2M1I8|uniprotkb:Q6UW83|uniprotkb:Q9H2D3|uniprotkb:Q9H2W8|uniprotkb:Q9H2W9|uniprotkb:Q9P0Z2|uniprotkb:Q9P0Z3|uniprotkb:Q9P0Z4|uniprotkb:Q9P0Z5|intact:EBI-1957537|ensembl:ENSP00000204604	psi-mi:nufp2_human(display_long)|uniprotkb:NUFIP2(gene name)|psi-mi:NUFIP2(display_short)|uniprotkb:KIAA1321(gene name synonym)|uniprotkb:PIG1(orf name)|uniprotkb:FMRP-interacting protein 2(gene name synonym)|uniprotkb:82 kDa FMRP-interacting protein(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 1 protein(gene name synonym)	psi-mi:chrd_human(display_long)|uniprotkb:CHRD(gene name)|psi-mi:CHRD(display_short)|uniprotkb:UNQ217/PRO243(orf name)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513380|imex:IM-28561-799	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_065823.1|dip:DIP-29023N|ensembl:ENSG00000108256(gene)|ensembl:ENST00000225388(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0042788"(polysomal ribosome)|interpro:IPR032747|mint:Q7Z417	refseq:NP_003732.2|refseq:NP_001291401.1|refseq:NP_001291402.1|refseq:NP_001291403.1|dip:DIP-48857N|ensembl:ENSG00000090539(gene)|ensembl:ENST00000204604(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0005615"(extracellular space)|go:"GO:0019955"(cytokine binding)|go:"GO:0021919"(BMP signaling pathway involved in spinal cord dorsal/ventral patterning)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0033504"(floor plate development)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR010895(CHRD)|interpro:IPR016353(Chordin)|mint:Q9H2X0	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:zdbkRisveP+8g70umfbEPHTnAgk9606	rogid:Y/WHkB30K8nEcaaL2wyikwWH1kg9606	rigid:d7UdDPt930EFgBVXjIu2kRTWaB8	false	sufficient binding region:1-340	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q7Z417	uniprotkb:O00468	intact:EBI-1210753|intact:EBI-10172018|uniprotkb:A1L3A7|uniprotkb:Q9P2M5|uniprotkb:A1L3A6|ensembl:ENSP00000225388	intact:EBI-947482|uniprotkb:Q5SVA2|uniprotkb:Q60FE1|uniprotkb:Q7KYS8|uniprotkb:Q8N4J5|uniprotkb:Q96IC1|uniprotkb:Q9BTD4|uniprotkb:Q5SVA1	psi-mi:nufp2_human(display_long)|uniprotkb:NUFIP2(gene name)|psi-mi:NUFIP2(display_short)|uniprotkb:KIAA1321(gene name synonym)|uniprotkb:PIG1(orf name)|uniprotkb:FMRP-interacting protein 2(gene name synonym)|uniprotkb:82 kDa FMRP-interacting protein(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 1 protein(gene name synonym)	psi-mi:agrin_human(display_long)|uniprotkb:AGRN(gene name)|psi-mi:AGRN(display_short)|uniprotkb:AGRIN(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513371|imex:IM-28561-1719	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_065823.1|dip:DIP-29023N|ensembl:ENSG00000108256(gene)|ensembl:ENST00000225388(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0042788"(polysomal ribosome)|interpro:IPR032747|mint:Q7Z417	refseq:NP_940978.2|interpro:IPR004850(Agrin NtA)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002049(EGF-like, laminin)|interpro:IPR003645(Follistatin-like, N-terminal)|interpro:IPR001791(Laminin G)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR000082(SEA)|interpro:IPR008993(TIMP-like, OB-fold)|refseq:XP_005244806.1|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR003884(Factor I membrane attack complex)|mint:O00468|go:"GO:0002162"(dystroglycan binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009888"(tissue development)|go:"GO:0016021"(integral component of membrane)|go:"GO:0033691"(sialic acid binding)|go:"GO:0035374"(chondroitin sulfate binding)|go:"GO:0043113"(receptor clustering)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043236"(laminin binding)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045162"(clustering of voltage-gated sodium channels)|go:"GO:0045202"(synapse)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050808"(synapse organization)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|reactome:R-HSA-1971475|reactome:R-HSA-2022928|reactome:R-HSA-2024096|reactome:R-HSA-216083|reactome:R-HSA-3000171|reactome:R-HSA-3000178|reactome:R-HSA-3560783|reactome:R-HSA-3560801|reactome:R-HSA-3656237|reactome:R-HSA-3656253|reactome:R-HSA-419037|reactome:R-HSA-4420332|reactome:R-HSA-975634|interpro:IPR036058|interpro:IPR036364|refseq:NP_001292204.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:zdbkRisveP+8g70umfbEPHTnAgk9606	rogid:LRk4v4aYLk5kep9EIbjjiCGM7OM9606	rigid:W5hnTiLR5hMZY676Nd4j8gMiUU8	false	sufficient binding region:1-340	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9NZ94	uniprotkb:Q8NHU6	intact:EBI-3920184|uniprotkb:Q9NZ95|uniprotkb:Q9NZ96|uniprotkb:D3DVV0|uniprotkb:Q9NZ97|uniprotkb:Q9P248|uniprotkb:Q8NCD0|ensembl:ENSP00000351591|uniprotkb:D3DVV1|uniprotkb:B2RBK1|uniprotkb:D2X2H6|uniprotkb:Q86V51	intact:EBI-624505|uniprotkb:A6NCI6|uniprotkb:Q5VV27|uniprotkb:Q96JT1|uniprotkb:Q9UFF0|uniprotkb:Q9Y2M3|uniprotkb:B4DG99|uniprotkb:B4DXF7|uniprotkb:E7EQD4|uniprotkb:B2RBX3|ensembl:ENSP00000347444	psi-mi:nlgn3_human(display_long)|uniprotkb:NLGN3(gene name)|psi-mi:NLGN3(display_short)|uniprotkb:KIAA1480(gene name synonym)|uniprotkb:NL3(gene name synonym)|uniprotkb:Gliotactin homolog(gene name synonym)	psi-mi:tdrd7_human(display_long)|uniprotkb:PCTAIRE2-binding protein(gene name synonym)|uniprotkb:PCTAIRE2BP(gene name synonym)|uniprotkb:TDRD7(gene name)|psi-mi:TDRD7(display_short)|uniprotkb:Tudor repeat associator with PCTAIRE-2(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513362|imex:IM-28561-593	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0098793"(presynapse)|refseq:NP_001160132.1|refseq:NP_061850.2|refseq:NP_851820.1|ensembl:ENSG00000196338(gene)|ensembl:ENST00000358741(transcript)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0009986"(cell surface)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030534"(adult behavior)|go:"GO:0035176"(social behavior)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0045202"(synapse)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048675"(axon extension)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050808"(synapse organization)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060024"(rhythmic synaptic transmission)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0071625"(vocalization behavior)|go:"GO:0089717"(spanning component of membrane)|go:"GO:0097104"(postsynaptic membrane assembly)|go:"GO:0097105"(presynaptic membrane assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098985"(asymmetric, glutamatergic, excitatory synapse)|go:"GO:0099054"(presynapse assembly)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR000460(Neuroligin)|interpro:IPR002018(Carboxylesterase, type B)|interpro:IPR019819|interpro:IPR029058|interpro:IPR030024|mint:Q9NZ94|reactome:R-HSA-6794361|go:"GO:0098983"(symmetric, GABA-ergic, inhibitory synapse)|refseq:NP_001308205.1	refseq:NP_001289813.1|refseq:NP_055105.2|rcsb pdb:3RCO|ensembl:ENSG00000196116(gene)|ensembl:ENST00000355295(transcript)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0003729"(mRNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0033391"(chromatoid body)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0070306"(lens fiber cell differentiation)|interpro:IPR002999(Tudor)|interpro:IPR025605|interpro:IPR035437|interpro:IPR037978|interpro:IPR041966|mint:Q8NHU6	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:OzGAr78JAaopeMCBpHnhVXP5DaU9606	rogid:VMaw7t5OgA2O0RRDagDVSc+vUUU9606	rigid:8+ZNdLfVPTZb7R9Re+TZd8W93XI	false	sufficient binding region:712-848	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9NZ94	uniprotkb:O43251	intact:EBI-3920184|uniprotkb:Q9NZ95|uniprotkb:Q9NZ96|uniprotkb:D3DVV0|uniprotkb:Q9NZ97|uniprotkb:Q9P248|uniprotkb:Q8NCD0|ensembl:ENSP00000351591|uniprotkb:D3DVV1|uniprotkb:B2RBK1|uniprotkb:D2X2H6|uniprotkb:Q86V51	intact:EBI-746056|uniprotkb:Q5TF71|uniprotkb:Q6IC09|uniprotkb:Q8TD00|uniprotkb:Q8WYB1|uniprotkb:Q96DZ6|uniprotkb:Q96NL7|uniprotkb:Q9UGW4|uniprotkb:Q9UH33|uniprotkb:Q0VH35|uniprotkb:A4F5G8|uniprotkb:A8K5Z5|uniprotkb:Q0PRL5|uniprotkb:B0QYY8|uniprotkb:B0QYY9	psi-mi:nlgn3_human(display_long)|uniprotkb:NLGN3(gene name)|psi-mi:NLGN3(display_short)|uniprotkb:KIAA1480(gene name synonym)|uniprotkb:NL3(gene name synonym)|uniprotkb:Gliotactin homolog(gene name synonym)	psi-mi:rfox2_human(display_long)|uniprotkb:FOX2(gene name synonym)|uniprotkb:RNA-binding motif protein 9(gene name synonym)|uniprotkb:Fox-1 homolog B(gene name synonym)|uniprotkb:Hexaribonucleotide-binding protein 2(gene name synonym)|uniprotkb:Repressor of tamoxifen transcriptional activity(gene name synonym)|uniprotkb:RBFOX2(gene name)|psi-mi:RBFOX2(display_short)|uniprotkb:HRNBP2(gene name synonym)|uniprotkb:RTA(gene name synonym)|uniprotkb:RBM9(gene name synonym)|uniprotkb:RNA-binding protein 9(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513353|imex:IM-28561-1717	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0098793"(presynapse)|refseq:NP_001160132.1|refseq:NP_061850.2|refseq:NP_851820.1|ensembl:ENSG00000196338(gene)|ensembl:ENST00000358741(transcript)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0009986"(cell surface)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030534"(adult behavior)|go:"GO:0035176"(social behavior)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0045202"(synapse)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048675"(axon extension)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050808"(synapse organization)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060024"(rhythmic synaptic transmission)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0071625"(vocalization behavior)|go:"GO:0089717"(spanning component of membrane)|go:"GO:0097104"(postsynaptic membrane assembly)|go:"GO:0097105"(presynaptic membrane assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098985"(asymmetric, glutamatergic, excitatory synapse)|go:"GO:0099054"(presynapse assembly)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR000460(Neuroligin)|interpro:IPR002018(Carboxylesterase, type B)|interpro:IPR019819|interpro:IPR029058|interpro:IPR030024|mint:Q9NZ94|reactome:R-HSA-6794361|go:"GO:0098983"(symmetric, GABA-ergic, inhibitory synapse)|refseq:NP_001308205.1	go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0007399"(nervous system development)|go:"GO:0008380"(RNA splicing)|go:"GO:0010724"(regulation of definitive erythrocyte differentiation)|go:"GO:0016070"(RNA metabolic process)|go:"GO:0021942"(radial glia guided migration of Purkinje cell)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|refseq:NP_001026865.1|refseq:NP_001076045.1|refseq:NP_001076046.1|refseq:NP_055124.1|interpro:IPR017325(RNA-binding protein 9/Ataxin-2-binding protein)|interpro:IPR000504(RNA recognition motif, RNP-1)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0140297"(DNA-binding transcription factor binding)|rcsb pdb:2CQ3|reactome:R-HSA-6803529|interpro:IPR025670|refseq:XP_005261494.1|interpro:IPR034237|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:O43251|interpro:IPR035979|refseq:NP_001076047.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:OzGAr78JAaopeMCBpHnhVXP5DaU9606	rogid:eIocECpScMWGhrZslIle29WUyKs9606	rigid:2HFC7hKFRib2dqqzjdzkxLBg6hU	false	sufficient binding region:712-848	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9NZ94	uniprotkb:Q9NRD5	intact:EBI-3920184|uniprotkb:Q9NZ95|uniprotkb:Q9NZ96|uniprotkb:D3DVV0|uniprotkb:Q9NZ97|uniprotkb:Q9P248|uniprotkb:Q8NCD0|ensembl:ENSP00000351591|uniprotkb:D3DVV1|uniprotkb:B2RBK1|uniprotkb:D2X2H6|uniprotkb:Q86V51	intact:EBI-79165|uniprotkb:O95906|ensembl:ENSP00000349465|ensembl:ENSP00000385205|intact:EBI-2622151|uniprotkb:B3KS52	psi-mi:nlgn3_human(display_long)|uniprotkb:NLGN3(gene name)|psi-mi:NLGN3(display_short)|uniprotkb:KIAA1480(gene name synonym)|uniprotkb:NL3(gene name synonym)|uniprotkb:Gliotactin homolog(gene name synonym)	psi-mi:pick1_human(display_long)|uniprotkb:PICK1(gene name)|psi-mi:PICK1(display_short)|uniprotkb:PRKCABP(gene name synonym)|uniprotkb:Protein kinase C-alpha-binding protein(gene name synonym)|uniprotkb:Protein interacting with C kinase 1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513344|imex:IM-28561-797	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0098793"(presynapse)|refseq:NP_001160132.1|refseq:NP_061850.2|refseq:NP_851820.1|ensembl:ENSG00000196338(gene)|ensembl:ENST00000358741(transcript)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0009986"(cell surface)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030534"(adult behavior)|go:"GO:0035176"(social behavior)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0045202"(synapse)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048675"(axon extension)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050808"(synapse organization)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060024"(rhythmic synaptic transmission)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0071625"(vocalization behavior)|go:"GO:0089717"(spanning component of membrane)|go:"GO:0097104"(postsynaptic membrane assembly)|go:"GO:0097105"(presynaptic membrane assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098985"(asymmetric, glutamatergic, excitatory synapse)|go:"GO:0099054"(presynapse assembly)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR000460(Neuroligin)|interpro:IPR002018(Carboxylesterase, type B)|interpro:IPR019819|interpro:IPR029058|interpro:IPR030024|mint:Q9NZ94|reactome:R-HSA-6794361|go:"GO:0098983"(symmetric, GABA-ergic, inhibitory synapse)|refseq:NP_001308205.1	ensembl:ENSG00000100151(gene)|ensembl:ENST00000356976(transcript)|ensembl:ENST00000404072(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|refseq:NP_001034672.1|refseq:NP_001034673.1|refseq:NP_036539.1|go:"GO:0015844"(monoamine transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021782"(glial cell development)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0034315"(regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0034316"(negative regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0036294"(cellular response to decreased oxygen levels)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0043113"(receptor clustering)|go:"GO:0045161"(neuronal ion channel clustering)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051015"(actin filament binding)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0098842"(postsynaptic early endosome)|go:"GO:0140090"(membrane curvature sensor activity)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR010504(Arfaptin-like)|interpro:IPR027267|interpro:IPR030798|interpro:IPR036034|interpro:IPR037959|mint:Q9NRD5|rcsb pdb:2GZV|rcsb pdb:6AR4|rcsb pdb:6BJN|rcsb pdb:6BJO|reactome:R-HSA-202733|reactome:R-HSA-416993	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:OzGAr78JAaopeMCBpHnhVXP5DaU9606	rogid:qRx+eNG7We8Oe0SQOekqpJpn8zk9606	rigid:Dp1bATzyr8Eov/Vo1rBFj4FlUGo	false	sufficient binding region:712-848	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9NZ94	uniprotkb:P15822	intact:EBI-3920184|uniprotkb:Q9NZ95|uniprotkb:Q9NZ96|uniprotkb:D3DVV0|uniprotkb:Q9NZ97|uniprotkb:Q9P248|uniprotkb:Q8NCD0|ensembl:ENSP00000351591|uniprotkb:D3DVV1|uniprotkb:B2RBK1|uniprotkb:D2X2H6|uniprotkb:Q86V51	intact:EBI-722264|uniprotkb:Q14122|uniprotkb:Q5VW60|uniprotkb:B2RTU3|uniprotkb:Q5MPB1|ensembl:ENSP00000368698	psi-mi:nlgn3_human(display_long)|uniprotkb:NLGN3(gene name)|psi-mi:NLGN3(display_short)|uniprotkb:KIAA1480(gene name synonym)|uniprotkb:NL3(gene name synonym)|uniprotkb:Gliotactin homolog(gene name synonym)	psi-mi:zep1_human(display_long)|uniprotkb:Human immunodeficiency virus type I enhancer-binding protein 1(gene name synonym)|uniprotkb:Major histocompatibility complex-binding protein 1(gene name synonym)|uniprotkb:Positive regulatory domain II-binding factor 1(gene name synonym)|uniprotkb:HIVEP1(gene name)|psi-mi:HIVEP1(display_short)|uniprotkb:ZNF40(gene name synonym)|uniprotkb:Gate keeper of apoptosis-activating protein(gene name synonym)|uniprotkb:Cirhin interaction protein(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513335|imex:IM-28561-151	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0098793"(presynapse)|refseq:NP_001160132.1|refseq:NP_061850.2|refseq:NP_851820.1|ensembl:ENSG00000196338(gene)|ensembl:ENST00000358741(transcript)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0009986"(cell surface)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030534"(adult behavior)|go:"GO:0035176"(social behavior)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0045202"(synapse)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048675"(axon extension)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050808"(synapse organization)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060024"(rhythmic synaptic transmission)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0071625"(vocalization behavior)|go:"GO:0089717"(spanning component of membrane)|go:"GO:0097104"(postsynaptic membrane assembly)|go:"GO:0097105"(presynaptic membrane assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098985"(asymmetric, glutamatergic, excitatory synapse)|go:"GO:0099054"(presynapse assembly)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR000460(Neuroligin)|interpro:IPR002018(Carboxylesterase, type B)|interpro:IPR019819|interpro:IPR029058|interpro:IPR030024|mint:Q9NZ94|reactome:R-HSA-6794361|go:"GO:0098983"(symmetric, GABA-ergic, inhibitory synapse)|refseq:NP_001308205.1	refseq:NP_002105.3|ensembl:ENSG00000095951(gene)|ensembl:ENST00000379388(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016604"(nuclear body)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR034729|interpro:IPR036236|mint:P15822|rcsb pdb:1BBO|rcsb pdb:3ZNF|rcsb pdb:4ZNF	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:OzGAr78JAaopeMCBpHnhVXP5DaU9606	rogid:rugwzqsTO0X8mJ5Zy3msTqc6dr09606	rigid:zPkETlZsW2bgUpQ7YhsY7Tn4mjo	false	sufficient binding region:712-848	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9NZ94	uniprotkb:Q12805	intact:EBI-3920184|uniprotkb:Q9NZ95|uniprotkb:Q9NZ96|uniprotkb:D3DVV0|uniprotkb:Q9NZ97|uniprotkb:Q9P248|uniprotkb:Q8NCD0|ensembl:ENSP00000351591|uniprotkb:D3DVV1|uniprotkb:B2RBK1|uniprotkb:D2X2H6|uniprotkb:Q86V51	intact:EBI-536772|uniprotkb:Q541U7|uniprotkb:A8K3I4|uniprotkb:D6W5D2|ensembl:ENSP00000347596|ensembl:ENSP00000378058|uniprotkb:B4DW75	psi-mi:nlgn3_human(display_long)|uniprotkb:NLGN3(gene name)|psi-mi:NLGN3(display_short)|uniprotkb:KIAA1480(gene name synonym)|uniprotkb:NL3(gene name synonym)|uniprotkb:Gliotactin homolog(gene name synonym)	psi-mi:fbln3_human(display_long)|uniprotkb:Fibulin-3(gene name synonym)|uniprotkb:Fibrillin-like protein(gene name synonym)|uniprotkb:Extracellular protein S1-5(gene name synonym)|uniprotkb:EFEMP1(gene name)|psi-mi:EFEMP1(display_short)|uniprotkb:FBLN3(gene name synonym)|uniprotkb:FBNL(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513326|imex:IM-28561-1043	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0098793"(presynapse)|refseq:NP_001160132.1|refseq:NP_061850.2|refseq:NP_851820.1|ensembl:ENSG00000196338(gene)|ensembl:ENST00000358741(transcript)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0009986"(cell surface)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030534"(adult behavior)|go:"GO:0035176"(social behavior)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0045202"(synapse)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048675"(axon extension)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050808"(synapse organization)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060024"(rhythmic synaptic transmission)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0071625"(vocalization behavior)|go:"GO:0089717"(spanning component of membrane)|go:"GO:0097104"(postsynaptic membrane assembly)|go:"GO:0097105"(presynaptic membrane assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098985"(asymmetric, glutamatergic, excitatory synapse)|go:"GO:0099054"(presynapse assembly)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR000460(Neuroligin)|interpro:IPR002018(Carboxylesterase, type B)|interpro:IPR019819|interpro:IPR029058|interpro:IPR030024|mint:Q9NZ94|reactome:R-HSA-6794361|go:"GO:0098983"(symmetric, GABA-ergic, inhibitory synapse)|refseq:NP_001308205.1	ensembl:ENSG00000115380(gene)|ensembl:ENST00000355426(transcript)|ensembl:ENST00000394555(transcript)|go:"GO:0005006"(epidermal growth factor-activated receptor activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007601"(visual perception)|go:"GO:0008083"(growth factor activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0043010"(camera-type eye development)|go:"GO:0048048"(embryonic eye morphogenesis)|go:"GO:0048050"(post-embryonic eye morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR018097|interpro:IPR026823|interpro:IPR032973|mint:Q12805|reactome:R-HSA-2129379|refseq:NP_001034437.1|refseq:NP_001034438.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:OzGAr78JAaopeMCBpHnhVXP5DaU9606	rogid:V32dS+EEp5Syu3A6lQJal0fg6UM9606	rigid:eD4xftYQo4G2hAVCrIFUcZEjeSE	false	sufficient binding region:712-848	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q7Z417	uniprotkb:P50542	intact:EBI-1210753|intact:EBI-10172018|uniprotkb:A1L3A7|uniprotkb:Q9P2M5|uniprotkb:A1L3A6|ensembl:ENSP00000225388	intact:EBI-597835|uniprotkb:Q15115|uniprotkb:Q15266|uniprotkb:Q96FN7|uniprotkb:B7ZAD5|uniprotkb:A8K891|uniprotkb:D3DUT8|uniprotkb:B4DZ45|intact:EBI-28971432|ensembl:ENSP00000400647|ensembl:ENSP00000410159|ensembl:ENSP00000499823|ensembl:ENSP00000500509|ensembl:ENSP00000502374	psi-mi:nufp2_human(display_long)|uniprotkb:NUFIP2(gene name)|psi-mi:NUFIP2(display_short)|uniprotkb:KIAA1321(gene name synonym)|uniprotkb:PIG1(orf name)|uniprotkb:FMRP-interacting protein 2(gene name synonym)|uniprotkb:82 kDa FMRP-interacting protein(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 1 protein(gene name synonym)	psi-mi:pex5_human(display_long)|uniprotkb:Peroxisome receptor 1(gene name synonym)|uniprotkb:Peroxisomal C-terminal targeting signal import receptor(gene name synonym)|uniprotkb:PTS1-BP(gene name synonym)|uniprotkb:Peroxin-5(gene name synonym)|uniprotkb:PEX5(gene name)|psi-mi:PEX5(display_short)|uniprotkb:PXR1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513551|imex:IM-28561-1049	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_065823.1|dip:DIP-29023N|ensembl:ENSG00000108256(gene)|ensembl:ENST00000225388(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0042788"(polysomal ribosome)|interpro:IPR032747|mint:Q7Z417	ensembl:ENST00000266563|ensembl:ENSP00000266563|ensembl:ENST00000266564|ensembl:ENSP00000266564|ensembl:ENSP00000410159|ensembl:ENST00000434354|ensembl:ENSP00000407401|ensembl:ENSP00000400647|ensembl:ENSP00000500509|ensembl:ENST00000672242|ensembl:ENSP00000500696|ensembl:ENST00000672541|ensembl:ENSP00000500043|ensembl:ENSP00000499823|ensembl:ENST00000672776|ensembl:ENSP00000500230|ensembl:ENSP00000502374|refseq:NP_001287718.1|refseq:XP_011519097.1|refseq:XP_011519099.1|refseq:XP_011519100.1|refseq:XP_011519101.1|refseq:XP_011519102.1|refseq:NP_000310.2|refseq:NP_001124496.1|refseq:NP_001124497.1|refseq:NP_001124498.1|refseq:XP_016875237.1|refseq:XP_016875238.1|refseq:NP_001124495.1|dip:DIP-34654N|refseq:XP_016875239.1|refseq:XP_016875241.1|refseq:XP_016875242.1|refseq:XP_016875243.1|refseq:XP_016875244.1|ensembl:ENSG00000139197(gene)|ensembl:ENSG00000288217(gene)|ensembl:ENST00000420616(transcript)|ensembl:ENST00000455147(transcript)|ensembl:ENST00000671993(transcript)|ensembl:ENST00000672694(transcript)|ensembl:ENST00000675855(transcript)|go:"GO:0000268"(peroxisome targeting sequence binding)|go:"GO:0005052"(peroxisome matrix targeting signal-1 binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005777"(peroxisome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006625"(protein targeting to peroxisome)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016020"(membrane)|go:"GO:0016558"(protein import into peroxisome matrix)|go:"GO:0016560"(protein import into peroxisome matrix, docking)|go:"GO:0016561"(protein import into peroxisome matrix, translocation)|go:"GO:0019899"(enzyme binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033328"(peroxisome membrane targeting sequence binding)|go:"GO:0045046"(protein import into peroxisome membrane)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0140311"(protein sequestering activity)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR024111|interpro:IPR024113|mint:P50542|rcsb pdb:1FCH|rcsb pdb:2C0L|rcsb pdb:2C0M|rcsb pdb:2J9Q|rcsb pdb:2W84|rcsb pdb:3R9A|rcsb pdb:4BXU|rcsb pdb:4KXK|rcsb pdb:4KYO|reactome:R-HSA-8866654|reactome:R-HSA-9033241|reactome:R-HSA-9664873	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:zdbkRisveP+8g70umfbEPHTnAgk9606	rogid:eTada01hgbdLE6GcBY29EGX+7QI9606	rigid:QdirDRvTWMV7aqHS4paHgJbnEeE	false	sufficient binding region:1-340	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:P35609	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-77797|uniprotkb:Q86TF4|ensembl:ENSP00000355537|uniprotkb:Q86TI8|uniprotkb:B1ANE4|intact:EBI-928705|uniprotkb:B2RCS5	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:actn2_human(display_long)|uniprotkb:ACTN2(gene name)|psi-mi:ACTN2(display_short)|uniprotkb:Alpha-actinin skeletal muscle isoform 2(gene name synonym)|uniprotkb:F-actin cross-linking protein(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513758|imex:IM-28561-377	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_001094.1|ensembl:ENSG00000077522(gene)|ensembl:ENST00000366578(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005925"(focal adhesion)|go:"GO:0006936"(muscle contraction)|go:"GO:0007155"(cell adhesion)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030018"(Z disc)|go:"GO:0030035"(microspike assembly)|go:"GO:0030175"(filopodium)|go:"GO:0030274"(LIM domain binding)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031143"(pseudopodium)|go:"GO:0031432"(titin binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043267"(negative regulation of potassium ion transport)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045214"(sarcomere organization)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051015"(actin filament binding)|go:"GO:0051373"(FATZ binding)|go:"GO:0051695"(actin filament uncapping)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070080"(titin Z domain binding)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086097"(phospholipase C-activating angiotensin-activated signaling pathway)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|go:"GO:2001137"(positive regulation of endocytic recycling)|go:"GO:0030374"(nuclear receptor coactivator activity)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR036872|mint:P35609|rcsb pdb:1H8B|rcsb pdb:1HCI|rcsb pdb:1QUU|rcsb pdb:4D1E|rcsb pdb:5A36|rcsb pdb:5A37|rcsb pdb:5A38|rcsb pdb:5A4B|rcsb pdb:6SWT|rcsb pdb:6TS3|rcsb pdb:7A8T|rcsb pdb:7A8U|reactome:R-HSA-114608|go:"GO:2001259"(positive regulation of cation channel activity)|reactome:R-HSA-373753|reactome:R-HSA-390522|reactome:R-HSA-442982|reactome:R-HSA-5673001|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-9620244|reactome:R-HSA-438066|refseq:NP_001265272.1|refseq:NP_001265273.1|dip:DIP-383N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:9jws8DZxpttkzqPfDxEzORNnwcE9606	rigid:qGqrfHLuzVtTXkdAooaUOPJIHl0	false	sufficient binding region:1219-1731,791-1222	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q7Z417	uniprotkb:Q8WUG5	intact:EBI-1210753|intact:EBI-10172018|uniprotkb:A1L3A7|uniprotkb:Q9P2M5|uniprotkb:A1L3A6|ensembl:ENSP00000225388	intact:EBI-11722858|uniprotkb:A4UA13|uniprotkb:A8MUT0|uniprotkb:Q2TAB0|uniprotkb:Q5BKY8|uniprotkb:Q86U04|uniprotkb:Q9H1D3|uniprotkb:Q9NQD5|intact:EBI-28972519|ensembl:ENSP00000380437	psi-mi:nufp2_human(display_long)|uniprotkb:NUFIP2(gene name)|psi-mi:NUFIP2(display_short)|uniprotkb:KIAA1321(gene name synonym)|uniprotkb:PIG1(orf name)|uniprotkb:FMRP-interacting protein 2(gene name synonym)|uniprotkb:82 kDa FMRP-interacting protein(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 1 protein(gene name synonym)	psi-mi:s22ah_human(display_long)|uniprotkb:SLC22A17(gene name)|psi-mi:SLC22A17(display_short)|uniprotkb:BOCT(gene name synonym)|uniprotkb:BOIT(gene name synonym)|uniprotkb:24p3 receptor(gene name synonym)|uniprotkb:Brain-type organic cation transporter(gene name synonym)|uniprotkb:Lipocalin-2 receptor(gene name synonym)|uniprotkb:Neutrophil gelatinase-associated lipocalin receptor(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513596|imex:IM-28561-1257	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_065823.1|dip:DIP-29023N|ensembl:ENSG00000108256(gene)|ensembl:ENST00000225388(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0042788"(polysomal ribosome)|interpro:IPR032747|mint:Q7Z417	ensembl:ENSP00000380437|refseq:NP_001275979.1|refseq:NP_057693.3|refseq:NP_065105.2|refseq:XP_005267804.1|ensembl:ENSG00000092096(gene)|ensembl:ENST00000397267(transcript)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005774"(vacuolar membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0015891"(siderophore transport)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0031301"(integral component of organelle membrane)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|mint:Q8WUG5|reactome:R-HSA-917937|refseq:XP_016876850.1|refseq:XP_016876851.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:zdbkRisveP+8g70umfbEPHTnAgk9606	rogid:peciW0vQDgfAgMZi55HD2dkd44Q9606	rigid:xcyD1C1KNtJLUB2nEWSkjlw4cE0	false	sufficient binding region:1-340	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q9NYB9	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-743598|uniprotkb:Q13147|uniprotkb:Q13249|uniprotkb:Q13801|uniprotkb:Q9BV70|uniprotkb:B4DSN1	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:abi2_human(display_long)|uniprotkb:Abelson interactor 2(gene name synonym)|uniprotkb:Abl-binding protein 3(gene name synonym)|uniprotkb:Arg-binding protein 1(gene name synonym)|uniprotkb:ABI2(gene name)|psi-mi:ABI2(display_short)|uniprotkb:ARGBPIA(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513740|imex:IM-28561-1729	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_001269854.1|refseq:NP_001269855.1|refseq:NP_001269856.1|refseq:NP_005750.4|go:"GO:0005912"(adherens junction)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007399"(nervous system development)|go:"GO:0008093"(cytoskeletal anchor activity)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0005856"(cytoskeleton)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019900"(kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0031209"(SCAR complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0045186"(zonula adherens assembly)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070309"(lens fiber cell morphogenesis)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028457|interpro:IPR035726|interpro:IPR036028|interpro:IPR036993|rcsb pdb:2ED0|rcsb pdb:3P8C|rcsb pdb:4N78|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9664422|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|refseq:XP_006712248.1|mint:Q9NYB9|dip:DIP-37566N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:ceor35u+atlarKgbnb1tTQXcSZQ9606	rigid:AOBREGC8YT09gKANK3pxZx/zX3o	false	sufficient binding region:374-740	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q8IZP0	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-375446|uniprotkb:O15147|uniprotkb:O76049|uniprotkb:O95060|uniprotkb:Q5W070|uniprotkb:Q5W072|uniprotkb:Q8TB63|uniprotkb:Q96S81|uniprotkb:Q9NXZ9|uniprotkb:Q9NYB8|intact:EBI-28968938|ensembl:ENSP00000365312|uniprotkb:A9Z1Y6|uniprotkb:Q5T2R3|uniprotkb:Q5T2R4|uniprotkb:Q5T2R6|uniprotkb:Q5T2R7|uniprotkb:B4DQ58|uniprotkb:Q5T2R9|uniprotkb:B3KX62|uniprotkb:H7BXI6	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:abi1_human(display_long)|uniprotkb:ABI1(gene name)|psi-mi:ABI1(display_short)|uniprotkb:SSH3BP1(gene name synonym)|uniprotkb:Abelson interactor 1(gene name synonym)|uniprotkb:Spectrin SH3 domain-binding protein 1(gene name synonym)|uniprotkb:Eps8 SH3 domain-binding protein(gene name synonym)|uniprotkb:e3B1(gene name synonym)|uniprotkb:Nap1-binding protein(gene name synonym)|uniprotkb:Abl-binding protein 4(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513731|imex:IM-28561-1267	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_001012768.1|refseq:NP_001012769.1|refseq:NP_001012770.1|refseq:NP_001171590.1|refseq:NP_001171591.1|go:"GO:0030027"(lamellipodium)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0030426"(growth cone)|go:"GO:0031209"(SCAR complex)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045296"(cadherin binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072673"(lamellipodium morphogenesis)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028456|interpro:IPR028457|interpro:IPR035725|interpro:IPR036028|mint:Q8IZP0|ensembl:ENST00000376142(transcript)|go:"GO:0001756"(somitogenesis)|ensembl:ENSG00000136754(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|refseq:NP_001171592.1|refseq:NP_001171593.1|refseq:NP_001171594.1|refseq:NP_001171595.1|refseq:NP_005461.2|ensembl:ENST00000346832|ensembl:ENSP00000279599|ensembl:ENST00000359188|ensembl:ENSP00000352114|ensembl:ENST00000376137|ensembl:ENSP00000365307|ensembl:ENST00000376138|ensembl:ENSP00000365308|ensembl:ENST00000376139|ensembl:ENSP00000365309|ensembl:ENST00000376140|ensembl:ENSP00000365310|ensembl:ENSP00000365312|ensembl:ENST00000376166|ensembl:ENSP00000365336|ensembl:ENST00000376170|ensembl:ENSP00000365340|ensembl:ENST00000490841|ensembl:ENSP00000440101|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9664422|refseq:NP_001171596.1|refseq:NP_001171587.1|dip:DIP-31118N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:mO2D5R8ZlYmsh+fXdJpaHZOssfs9606	rigid:4o/dw7k18oyjSLWjF9y2EPcwl8A	false	sufficient binding region:374-740,791-1222	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P60484	uniprotkb:Q8IY57	intact:EBI-696162|uniprotkb:O00633|uniprotkb:O02679|uniprotkb:Q6ICT7|uniprotkb:B2R904|uniprotkb:F2YHV0|ensembl:ENSP00000361021	intact:EBI-2842031|uniprotkb:A8K5P0|uniprotkb:Q99710|uniprotkb:B4DFU3|uniprotkb:G3V465|ensembl:ENSP00000439256	psi-mi:pten_human(display_long)|uniprotkb:Phosphatase and tensin homolog(gene name synonym)|uniprotkb:Mutated in multiple advanced cancers 1(gene name synonym)|uniprotkb:PTEN(gene name)|psi-mi:PTEN(display_short)|uniprotkb:MMAC1(gene name synonym)|uniprotkb:TEP1(gene name synonym)	psi-mi:yaf2_human(display_long)|uniprotkb:YAF2(gene name)|psi-mi:YAF2(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513722|imex:IM-28561-1265	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000305.3|refseq:NP_001291646.2|refseq:NP_001291647.1|dip:DIP-35019N|ensembl:ENSG00000171862(gene)|ensembl:ENST00000371953(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002902"(regulation of B cell apoptotic process)|go:"GO:0004438"(phosphatidylinositol-3-phosphatase activity)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007270"(neuron-neuron synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007417"(central nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0007611"(learning or memory)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0009749"(response to glucose)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016314"(phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030534"(adult behavior)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0032286"(central nervous system myelin maintenance)|go:"GO:0032355"(response to estradiol)|go:"GO:0032535"(regulation of cellular component size)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033032"(regulation of myeloid cell apoptotic process)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0033198"(response to ATP)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035749"(myelin sheath adaxonal region)|go:"GO:0042493"|go:"GO:0042711"(maternal behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0046855"(inositol phosphate dephosphorylation)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048681"(negative regulation of axon regeneration)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051548"(negative regulation of keratinocyte migration)|go:"GO:0051717"(inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity)|go:"GO:0051800"(phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060024"(rhythmic synaptic transmission)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060074"(synapse maturation)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061002"(negative regulation of dendritic spine morphogenesis)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071257"(cellular response to electrical stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090071"(negative regulation of ribosome biogenesis)|go:"GO:0090344"(negative regulation of cell aging)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097105"(presynaptic membrane assembly)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1902807"(negative regulation of cell cycle G1/S phase transition)|go:"GO:1903690"(negative regulation of wound healing, spreading of epidermal cells)|go:"GO:1903984"(positive regulation of TRAIL-activated apoptotic signaling pathway)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000808"(negative regulation of synaptic vesicle clustering)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR014020(C2 tensin-type)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR017361(Bifunctional phosphatidylinositol trisphosphate phosphatase/dual-specificity phosphatase PTEN)|interpro:IPR029021|interpro:IPR029023|interpro:IPR035892|mint:P60484|rcsb pdb:1D5R|rcsb pdb:2KYL|rcsb pdb:4O1V|rcsb pdb:5BUG|rcsb pdb:5BZX|rcsb pdb:5BZZ|reactome:R-HSA-1660499|reactome:R-HSA-1855204|reactome:R-HSA-199418|reactome:R-HSA-202424|reactome:R-HSA-5628897|reactome:R-HSA-5674404|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-8943723|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-8986944	refseq:NP_001177906.1|refseq:NP_001177908.1|refseq:NP_005739.2|refseq:NP_001177909.1|ensembl:ENSG00000015153(gene)|ensembl:ENST00000534854(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR033774|interpro:IPR036443|interpro:IPR038039|interpro:IPR039958|mint:Q8IY57|rcsb pdb:2D9G|reactome:R-HSA-8939243|reactome:R-HSA-8953750|dip:DIP-44919N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:/cPQox/hRcR/ED//46U5w4lcsyc9606	rogid:x+0HcNK10qVfo3nfvTjMdF/zb649606	rigid:BhqcMWkT6GQiYShkjB2miN9Hvzc	false	sufficient binding region:305-403	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P60484	uniprotkb:Q8N488	intact:EBI-696162|uniprotkb:O00633|uniprotkb:O02679|uniprotkb:Q6ICT7|uniprotkb:B2R904|uniprotkb:F2YHV0|ensembl:ENSP00000361021	intact:EBI-752324|uniprotkb:Q9P2W5|uniprotkb:Q9UMW4|ensembl:ENSP00000419494	psi-mi:pten_human(display_long)|uniprotkb:Phosphatase and tensin homolog(gene name synonym)|uniprotkb:Mutated in multiple advanced cancers 1(gene name synonym)|uniprotkb:PTEN(gene name)|psi-mi:PTEN(display_short)|uniprotkb:MMAC1(gene name synonym)|uniprotkb:TEP1(gene name synonym)	psi-mi:rybp_human(display_long)|uniprotkb:Death effector domain-associated factor(gene name synonym)|uniprotkb:YY1 and E4TF1-associated factor 1(gene name synonym)|uniprotkb:Apoptin-associating protein 1(gene name synonym)|uniprotkb:RYBP(gene name)|psi-mi:RYBP(display_short)|uniprotkb:DEDAF(gene name synonym)|uniprotkb:YEAF1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513713|imex:IM-28561-1053	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000305.3|refseq:NP_001291646.2|refseq:NP_001291647.1|dip:DIP-35019N|ensembl:ENSG00000171862(gene)|ensembl:ENST00000371953(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002902"(regulation of B cell apoptotic process)|go:"GO:0004438"(phosphatidylinositol-3-phosphatase activity)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007270"(neuron-neuron synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007417"(central nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0007611"(learning or memory)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0009749"(response to glucose)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016314"(phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030534"(adult behavior)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0032286"(central nervous system myelin maintenance)|go:"GO:0032355"(response to estradiol)|go:"GO:0032535"(regulation of cellular component size)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033032"(regulation of myeloid cell apoptotic process)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0033198"(response to ATP)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035749"(myelin sheath adaxonal region)|go:"GO:0042493"|go:"GO:0042711"(maternal behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0046855"(inositol phosphate dephosphorylation)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048681"(negative regulation of axon regeneration)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051548"(negative regulation of keratinocyte migration)|go:"GO:0051717"(inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity)|go:"GO:0051800"(phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060024"(rhythmic synaptic transmission)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060074"(synapse maturation)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061002"(negative regulation of dendritic spine morphogenesis)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071257"(cellular response to electrical stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090071"(negative regulation of ribosome biogenesis)|go:"GO:0090344"(negative regulation of cell aging)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097105"(presynaptic membrane assembly)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1902807"(negative regulation of cell cycle G1/S phase transition)|go:"GO:1903690"(negative regulation of wound healing, spreading of epidermal cells)|go:"GO:1903984"(positive regulation of TRAIL-activated apoptotic signaling pathway)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000808"(negative regulation of synaptic vesicle clustering)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR014020(C2 tensin-type)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR017361(Bifunctional phosphatidylinositol trisphosphate phosphatase/dual-specificity phosphatase PTEN)|interpro:IPR029021|interpro:IPR029023|interpro:IPR035892|mint:P60484|rcsb pdb:1D5R|rcsb pdb:2KYL|rcsb pdb:4O1V|rcsb pdb:5BUG|rcsb pdb:5BZX|rcsb pdb:5BZZ|reactome:R-HSA-1660499|reactome:R-HSA-1855204|reactome:R-HSA-199418|reactome:R-HSA-202424|reactome:R-HSA-5628897|reactome:R-HSA-5674404|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-8943723|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-8986944	refseq:NP_036366.3|dip:DIP-41435N|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0007275"(multicellular organism development)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR033774|interpro:IPR036443|interpro:IPR039958|mint:Q8N488|rcsb pdb:3IXS|reactome:R-HSA-8939243|reactome:R-HSA-8953750|ensembl:ENSG00000163602(gene)|ensembl:ENST00000477973(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:/cPQox/hRcR/ED//46U5w4lcsyc9606	rogid:t9ef8aO/5xEAB3hMlElJCktEIOU9606	rigid:9oMv5APULNeulRmI1WPces7DZFc	false	sufficient binding region:305-403	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P60484	uniprotkb:Q9NRD5	intact:EBI-696162|uniprotkb:O00633|uniprotkb:O02679|uniprotkb:Q6ICT7|uniprotkb:B2R904|uniprotkb:F2YHV0|ensembl:ENSP00000361021	intact:EBI-79165|uniprotkb:O95906|ensembl:ENSP00000349465|ensembl:ENSP00000385205|intact:EBI-2622151|uniprotkb:B3KS52	psi-mi:pten_human(display_long)|uniprotkb:Phosphatase and tensin homolog(gene name synonym)|uniprotkb:Mutated in multiple advanced cancers 1(gene name synonym)|uniprotkb:PTEN(gene name)|psi-mi:PTEN(display_short)|uniprotkb:MMAC1(gene name synonym)|uniprotkb:TEP1(gene name synonym)	psi-mi:pick1_human(display_long)|uniprotkb:PICK1(gene name)|psi-mi:PICK1(display_short)|uniprotkb:PRKCABP(gene name synonym)|uniprotkb:Protein kinase C-alpha-binding protein(gene name synonym)|uniprotkb:Protein interacting with C kinase 1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513704|imex:IM-28561-1263	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000305.3|refseq:NP_001291646.2|refseq:NP_001291647.1|dip:DIP-35019N|ensembl:ENSG00000171862(gene)|ensembl:ENST00000371953(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002902"(regulation of B cell apoptotic process)|go:"GO:0004438"(phosphatidylinositol-3-phosphatase activity)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007270"(neuron-neuron synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007417"(central nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0007611"(learning or memory)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0009749"(response to glucose)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016314"(phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030534"(adult behavior)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0032286"(central nervous system myelin maintenance)|go:"GO:0032355"(response to estradiol)|go:"GO:0032535"(regulation of cellular component size)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033032"(regulation of myeloid cell apoptotic process)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0033198"(response to ATP)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035749"(myelin sheath adaxonal region)|go:"GO:0042493"|go:"GO:0042711"(maternal behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0046855"(inositol phosphate dephosphorylation)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048681"(negative regulation of axon regeneration)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051548"(negative regulation of keratinocyte migration)|go:"GO:0051717"(inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity)|go:"GO:0051800"(phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060024"(rhythmic synaptic transmission)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060074"(synapse maturation)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061002"(negative regulation of dendritic spine morphogenesis)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071257"(cellular response to electrical stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090071"(negative regulation of ribosome biogenesis)|go:"GO:0090344"(negative regulation of cell aging)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097105"(presynaptic membrane assembly)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1902807"(negative regulation of cell cycle G1/S phase transition)|go:"GO:1903690"(negative regulation of wound healing, spreading of epidermal cells)|go:"GO:1903984"(positive regulation of TRAIL-activated apoptotic signaling pathway)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000808"(negative regulation of synaptic vesicle clustering)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR014020(C2 tensin-type)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR017361(Bifunctional phosphatidylinositol trisphosphate phosphatase/dual-specificity phosphatase PTEN)|interpro:IPR029021|interpro:IPR029023|interpro:IPR035892|mint:P60484|rcsb pdb:1D5R|rcsb pdb:2KYL|rcsb pdb:4O1V|rcsb pdb:5BUG|rcsb pdb:5BZX|rcsb pdb:5BZZ|reactome:R-HSA-1660499|reactome:R-HSA-1855204|reactome:R-HSA-199418|reactome:R-HSA-202424|reactome:R-HSA-5628897|reactome:R-HSA-5674404|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-8943723|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-8986944	ensembl:ENSG00000100151(gene)|ensembl:ENST00000356976(transcript)|ensembl:ENST00000404072(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|refseq:NP_001034672.1|refseq:NP_001034673.1|refseq:NP_036539.1|go:"GO:0015844"(monoamine transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021782"(glial cell development)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0034315"(regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0034316"(negative regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0036294"(cellular response to decreased oxygen levels)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0043113"(receptor clustering)|go:"GO:0045161"(neuronal ion channel clustering)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051015"(actin filament binding)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0098842"(postsynaptic early endosome)|go:"GO:0140090"(membrane curvature sensor activity)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR010504(Arfaptin-like)|interpro:IPR027267|interpro:IPR030798|interpro:IPR036034|interpro:IPR037959|mint:Q9NRD5|rcsb pdb:2GZV|rcsb pdb:6AR4|rcsb pdb:6BJN|rcsb pdb:6BJO|reactome:R-HSA-202733|reactome:R-HSA-416993	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:/cPQox/hRcR/ED//46U5w4lcsyc9606	rogid:qRx+eNG7We8Oe0SQOekqpJpn8zk9606	rigid:eIpCQZ+eXWhXeTG5faLAZoQ9HdE	false	sufficient binding region:305-403	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P60484	uniprotkb:Q6WCQ1	intact:EBI-696162|uniprotkb:O00633|uniprotkb:O02679|uniprotkb:Q6ICT7|uniprotkb:B2R904|uniprotkb:F2YHV0|ensembl:ENSP00000361021	intact:EBI-1022605|uniprotkb:Q3KQZ5|uniprotkb:Q5FB94|uniprotkb:Q6DHW2|uniprotkb:Q7Z5Y2|uniprotkb:Q8N390|uniprotkb:Q96G40|ensembl:ENSP00000342379	psi-mi:pten_human(display_long)|uniprotkb:Phosphatase and tensin homolog(gene name synonym)|uniprotkb:Mutated in multiple advanced cancers 1(gene name synonym)|uniprotkb:PTEN(gene name)|psi-mi:PTEN(display_short)|uniprotkb:MMAC1(gene name synonym)|uniprotkb:TEP1(gene name synonym)	psi-mi:mprip_human(display_long)|uniprotkb:MRIP(gene name synonym)|uniprotkb:Rho-interacting protein 3(gene name synonym)|uniprotkb:p116Rip(gene name synonym)|uniprotkb:MPRIP(gene name)|psi-mi:MPRIP(display_short)|uniprotkb:KIAA0864(gene name synonym)|uniprotkb:RHOIP3(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513695|imex:IM-28561-1727	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000305.3|refseq:NP_001291646.2|refseq:NP_001291647.1|dip:DIP-35019N|ensembl:ENSG00000171862(gene)|ensembl:ENST00000371953(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002902"(regulation of B cell apoptotic process)|go:"GO:0004438"(phosphatidylinositol-3-phosphatase activity)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007270"(neuron-neuron synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007417"(central nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0007611"(learning or memory)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0009749"(response to glucose)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016314"(phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030534"(adult behavior)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0032286"(central nervous system myelin maintenance)|go:"GO:0032355"(response to estradiol)|go:"GO:0032535"(regulation of cellular component size)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033032"(regulation of myeloid cell apoptotic process)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0033198"(response to ATP)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035749"(myelin sheath adaxonal region)|go:"GO:0042493"|go:"GO:0042711"(maternal behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0046855"(inositol phosphate dephosphorylation)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048681"(negative regulation of axon regeneration)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051548"(negative regulation of keratinocyte migration)|go:"GO:0051717"(inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity)|go:"GO:0051800"(phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060024"(rhythmic synaptic transmission)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060074"(synapse maturation)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061002"(negative regulation of dendritic spine morphogenesis)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071257"(cellular response to electrical stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090071"(negative regulation of ribosome biogenesis)|go:"GO:0090344"(negative regulation of cell aging)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097105"(presynaptic membrane assembly)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1902807"(negative regulation of cell cycle G1/S phase transition)|go:"GO:1903690"(negative regulation of wound healing, spreading of epidermal cells)|go:"GO:1903984"(positive regulation of TRAIL-activated apoptotic signaling pathway)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000808"(negative regulation of synaptic vesicle clustering)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR014020(C2 tensin-type)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR017361(Bifunctional phosphatidylinositol trisphosphate phosphatase/dual-specificity phosphatase PTEN)|interpro:IPR029021|interpro:IPR029023|interpro:IPR035892|mint:P60484|rcsb pdb:1D5R|rcsb pdb:2KYL|rcsb pdb:4O1V|rcsb pdb:5BUG|rcsb pdb:5BZX|rcsb pdb:5BZZ|reactome:R-HSA-1660499|reactome:R-HSA-1855204|reactome:R-HSA-199418|reactome:R-HSA-202424|reactome:R-HSA-5628897|reactome:R-HSA-5674404|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-8943723|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-8986944	ensembl:ENSG00000133030(gene)|ensembl:ENST00000341712(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0045296"(cadherin binding)|go:"GO:0051015"(actin filament binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039597|mint:Q6WCQ1|reactome:R-HSA-6802952|refseq:NP_055949.2|refseq:NP_958431.2	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:/cPQox/hRcR/ED//46U5w4lcsyc9606	rogid:QoGbbg2ehuQogDM1Dlxzw6xj59s9606	rigid:zo727czFVzWt6WSLJ7+3wctwDzU	false	sufficient binding region:305-403	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P60484	uniprotkb:P21333	intact:EBI-696162|uniprotkb:O00633|uniprotkb:O02679|uniprotkb:Q6ICT7|uniprotkb:B2R904|uniprotkb:F2YHV0|ensembl:ENSP00000361021	intact:EBI-350432|uniprotkb:Q8NF52|intact:EBI-1103234|ensembl:ENSP00000358866|uniprotkb:Q5HY53|uniprotkb:Q5HY55|uniprotkb:E9KL45	psi-mi:pten_human(display_long)|uniprotkb:Phosphatase and tensin homolog(gene name synonym)|uniprotkb:Mutated in multiple advanced cancers 1(gene name synonym)|uniprotkb:PTEN(gene name)|psi-mi:PTEN(display_short)|uniprotkb:MMAC1(gene name synonym)|uniprotkb:TEP1(gene name synonym)	psi-mi:flna_human(display_long)|uniprotkb:FLNA(gene name)|psi-mi:FLNA(display_short)|uniprotkb:FLN(gene name synonym)|uniprotkb:FLN1(gene name synonym)|uniprotkb:Alpha-filamin(gene name synonym)|uniprotkb:Filamin-1(gene name synonym)|uniprotkb:Endothelial actin-binding protein(gene name synonym)|uniprotkb:Actin-binding protein 280(gene name synonym)|uniprotkb:Non-muscle filamin(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513686|imex:IM-28561-1725	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000305.3|refseq:NP_001291646.2|refseq:NP_001291647.1|dip:DIP-35019N|ensembl:ENSG00000171862(gene)|ensembl:ENST00000371953(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002902"(regulation of B cell apoptotic process)|go:"GO:0004438"(phosphatidylinositol-3-phosphatase activity)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007270"(neuron-neuron synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007417"(central nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0007611"(learning or memory)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0009749"(response to glucose)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016314"(phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030534"(adult behavior)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0032286"(central nervous system myelin maintenance)|go:"GO:0032355"(response to estradiol)|go:"GO:0032535"(regulation of cellular component size)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033032"(regulation of myeloid cell apoptotic process)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0033198"(response to ATP)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035749"(myelin sheath adaxonal region)|go:"GO:0042493"|go:"GO:0042711"(maternal behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0046855"(inositol phosphate dephosphorylation)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048681"(negative regulation of axon regeneration)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051548"(negative regulation of keratinocyte migration)|go:"GO:0051717"(inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity)|go:"GO:0051800"(phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060024"(rhythmic synaptic transmission)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060074"(synapse maturation)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061002"(negative regulation of dendritic spine morphogenesis)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071257"(cellular response to electrical stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090071"(negative regulation of ribosome biogenesis)|go:"GO:0090344"(negative regulation of cell aging)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097105"(presynaptic membrane assembly)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1902807"(negative regulation of cell cycle G1/S phase transition)|go:"GO:1903690"(negative regulation of wound healing, spreading of epidermal cells)|go:"GO:1903984"(positive regulation of TRAIL-activated apoptotic signaling pathway)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000808"(negative regulation of synaptic vesicle clustering)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR014020(C2 tensin-type)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR017361(Bifunctional phosphatidylinositol trisphosphate phosphatase/dual-specificity phosphatase PTEN)|interpro:IPR029021|interpro:IPR029023|interpro:IPR035892|mint:P60484|rcsb pdb:1D5R|rcsb pdb:2KYL|rcsb pdb:4O1V|rcsb pdb:5BUG|rcsb pdb:5BZX|rcsb pdb:5BZZ|reactome:R-HSA-1660499|reactome:R-HSA-1855204|reactome:R-HSA-199418|reactome:R-HSA-202424|reactome:R-HSA-5628897|reactome:R-HSA-5674404|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-8943723|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-8986944	go:"GO:0007195"(adenylate cyclase-inhibiting dopamine receptor signaling pathway)|go:"GO:1902396"(protein localization to bicellular tight junction)|refseq:NP_001104026.1|refseq:NP_001447.2|ensembl:ENSG00000196924(gene)|ensembl:ENST00000369850(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048680"(positive regulation of axon regeneration)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051015"(actin filament binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0051764"(actin crosslink formation)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090042"(tubulin deacetylation)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0097368"(establishment of Sertoli cell barrier)|go:"GO:0097440"(apical dendrite)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901381"(positive regulation of potassium ion transmembrane transport)|go:"GO:0046332"(SMAD binding)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016479"(negative regulation of transcription by RNA polymerase I)|go:"GO:0019900"(kinase binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0021943"(formation of radial glial scaffolds)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030018"(Z disc)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031523"(Myb complex)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031852"(mu-type opioid receptor binding)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0032432"(actin filament bundle)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034988"(Fc-gamma receptor I complex binding)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043113"(receptor clustering)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045296"(cadherin binding)|reactome:R-HSA-114608|reactome:R-HSA-430116|reactome:R-HSA-446353|reactome:R-HSA-5627123|reactome:R-HSA-8983711|rcsb pdb:6EW1|go:"GO:1905031"(regulation of membrane repolarization during cardiac muscle cell action potential)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2001046"(positive regulation of integrin-mediated signaling pathway)|go:"GO:2001224"(positive regulation of neuron migration)|interpro:IPR001298(Filamin/ABP280 repeat)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR036872|interpro:IPR044801|mint:P21333|rcsb pdb:2AAV|rcsb pdb:2BP3|rcsb pdb:2BRQ|rcsb pdb:2J3S|rcsb pdb:2JF1|rcsb pdb:2K3T|rcsb pdb:2K7P|rcsb pdb:2K7Q|rcsb pdb:2MTP|rcsb pdb:2W0P|rcsb pdb:2WFN|rcsb pdb:3CNK|rcsb pdb:3HOC|rcsb pdb:3HOP|rcsb pdb:3HOR|rcsb pdb:3ISW|rcsb pdb:3RGH|rcsb pdb:4M9P|rcsb pdb:4P3W|rcsb pdb:5XR1|rcsb pdb:6D8C|go:"GO:1905000"(regulation of membrane repolarization during atrial cardiac muscle cell action potential)|dip:DIP-1136N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:/cPQox/hRcR/ED//46U5w4lcsyc9606	rogid:ZxGK5OSMy8cNsyt7Ax2KXb8bn9M9606	rigid:pz6b8EO+MVUnKrH34aVjy5gd6d0	false	sufficient binding region:305-403	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P60484	uniprotkb:O00423	intact:EBI-696162|uniprotkb:O00633|uniprotkb:O02679|uniprotkb:Q6ICT7|uniprotkb:B2R904|uniprotkb:F2YHV0|ensembl:ENSP00000361021	intact:EBI-751327|uniprotkb:Q86U15|uniprotkb:Q8N536|uniprotkb:Q8N5C4|uniprotkb:Q8WWL6|ensembl:ENSP00000262233	psi-mi:pten_human(display_long)|uniprotkb:Phosphatase and tensin homolog(gene name synonym)|uniprotkb:Mutated in multiple advanced cancers 1(gene name synonym)|uniprotkb:PTEN(gene name)|psi-mi:PTEN(display_short)|uniprotkb:MMAC1(gene name synonym)|uniprotkb:TEP1(gene name synonym)	psi-mi:emal1_human(display_long)|uniprotkb:EML1(gene name)|psi-mi:EML1(display_short)|uniprotkb:EMAP1(gene name synonym)|uniprotkb:EMAPL(gene name synonym)|uniprotkb:EMAPL1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513677|imex:IM-28561-1051	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000305.3|refseq:NP_001291646.2|refseq:NP_001291647.1|dip:DIP-35019N|ensembl:ENSG00000171862(gene)|ensembl:ENST00000371953(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002902"(regulation of B cell apoptotic process)|go:"GO:0004438"(phosphatidylinositol-3-phosphatase activity)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007270"(neuron-neuron synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007417"(central nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0007611"(learning or memory)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0009749"(response to glucose)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016314"(phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030534"(adult behavior)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0032286"(central nervous system myelin maintenance)|go:"GO:0032355"(response to estradiol)|go:"GO:0032535"(regulation of cellular component size)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033032"(regulation of myeloid cell apoptotic process)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0033198"(response to ATP)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035749"(myelin sheath adaxonal region)|go:"GO:0042493"|go:"GO:0042711"(maternal behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0046855"(inositol phosphate dephosphorylation)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048681"(negative regulation of axon regeneration)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051548"(negative regulation of keratinocyte migration)|go:"GO:0051717"(inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity)|go:"GO:0051800"(phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060024"(rhythmic synaptic transmission)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060074"(synapse maturation)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061002"(negative regulation of dendritic spine morphogenesis)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071257"(cellular response to electrical stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090071"(negative regulation of ribosome biogenesis)|go:"GO:0090344"(negative regulation of cell aging)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097105"(presynaptic membrane assembly)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1902807"(negative regulation of cell cycle G1/S phase transition)|go:"GO:1903690"(negative regulation of wound healing, spreading of epidermal cells)|go:"GO:1903984"(positive regulation of TRAIL-activated apoptotic signaling pathway)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000808"(negative regulation of synaptic vesicle clustering)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR014020(C2 tensin-type)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR017361(Bifunctional phosphatidylinositol trisphosphate phosphatase/dual-specificity phosphatase PTEN)|interpro:IPR029021|interpro:IPR029023|interpro:IPR035892|mint:P60484|rcsb pdb:1D5R|rcsb pdb:2KYL|rcsb pdb:4O1V|rcsb pdb:5BUG|rcsb pdb:5BZX|rcsb pdb:5BZZ|reactome:R-HSA-1660499|reactome:R-HSA-1855204|reactome:R-HSA-199418|reactome:R-HSA-202424|reactome:R-HSA-5628897|reactome:R-HSA-5674404|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-8943723|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-8986944	refseq:NP_001008707.1|refseq:NP_004425.2|ensembl:ENSG00000066629(gene)|ensembl:ENST00000262233(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0007420"(brain development)|go:"GO:0008017"(microtubule binding)|go:"GO:0015631"(tubulin binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:1990023"(mitotic spindle midzone)|interpro:IPR001680(WD40 repeat)|interpro:IPR005108(HELP)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|mint:O00423|rcsb pdb:4CI8	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:/cPQox/hRcR/ED//46U5w4lcsyc9606	rogid:hfGdCoFa3Miii6W/ozQuZ2cFiHs9606	rigid:/obhGOzbIW1haiKm1k1lnH5j40Y	false	sufficient binding region:305-403	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P60484	uniprotkb:Q9P0U4	intact:EBI-696162|uniprotkb:O00633|uniprotkb:O02679|uniprotkb:Q6ICT7|uniprotkb:B2R904|uniprotkb:F2YHV0|ensembl:ENSP00000361021	intact:EBI-949911|ensembl:ENSP00000285106|uniprotkb:Q8N2W4|uniprotkb:Q96BC8|uniprotkb:Q9P2V7|uniprotkb:B2RC03	psi-mi:pten_human(display_long)|uniprotkb:Phosphatase and tensin homolog(gene name synonym)|uniprotkb:Mutated in multiple advanced cancers 1(gene name synonym)|uniprotkb:PTEN(gene name)|psi-mi:PTEN(display_short)|uniprotkb:MMAC1(gene name synonym)|uniprotkb:TEP1(gene name synonym)	psi-mi:cxxc1_human(display_long)|uniprotkb:CFP1(gene name synonym)|uniprotkb:PHD finger and CXXC domain-containing protein 1(gene name synonym)|uniprotkb:CXXC1(gene name)|psi-mi:CXXC1(display_short)|uniprotkb:CGBP(gene name synonym)|uniprotkb:PCCX1(gene name synonym)|uniprotkb:PHF18(gene name synonym)|uniprotkb:CpG-binding protein(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513668|imex:IM-28561-1261	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000305.3|refseq:NP_001291646.2|refseq:NP_001291647.1|dip:DIP-35019N|ensembl:ENSG00000171862(gene)|ensembl:ENST00000371953(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002902"(regulation of B cell apoptotic process)|go:"GO:0004438"(phosphatidylinositol-3-phosphatase activity)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007270"(neuron-neuron synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007417"(central nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0007611"(learning or memory)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0009749"(response to glucose)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016314"(phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030534"(adult behavior)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0032286"(central nervous system myelin maintenance)|go:"GO:0032355"(response to estradiol)|go:"GO:0032535"(regulation of cellular component size)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033032"(regulation of myeloid cell apoptotic process)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0033198"(response to ATP)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035749"(myelin sheath adaxonal region)|go:"GO:0042493"|go:"GO:0042711"(maternal behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0046855"(inositol phosphate dephosphorylation)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048681"(negative regulation of axon regeneration)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051548"(negative regulation of keratinocyte migration)|go:"GO:0051717"(inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity)|go:"GO:0051800"(phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060024"(rhythmic synaptic transmission)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060074"(synapse maturation)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061002"(negative regulation of dendritic spine morphogenesis)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071257"(cellular response to electrical stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090071"(negative regulation of ribosome biogenesis)|go:"GO:0090344"(negative regulation of cell aging)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097105"(presynaptic membrane assembly)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1902807"(negative regulation of cell cycle G1/S phase transition)|go:"GO:1903690"(negative regulation of wound healing, spreading of epidermal cells)|go:"GO:1903984"(positive regulation of TRAIL-activated apoptotic signaling pathway)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000808"(negative regulation of synaptic vesicle clustering)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR014020(C2 tensin-type)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR017361(Bifunctional phosphatidylinositol trisphosphate phosphatase/dual-specificity phosphatase PTEN)|interpro:IPR029021|interpro:IPR029023|interpro:IPR035892|mint:P60484|rcsb pdb:1D5R|rcsb pdb:2KYL|rcsb pdb:4O1V|rcsb pdb:5BUG|rcsb pdb:5BZX|rcsb pdb:5BZZ|reactome:R-HSA-1660499|reactome:R-HSA-1855204|reactome:R-HSA-199418|reactome:R-HSA-202424|reactome:R-HSA-5628897|reactome:R-HSA-5674404|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-8943723|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-8986944	ensembl:ENSG00000154832(gene)|ensembl:ENST00000285106(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048188"(Set1C/COMPASS complex)|go:"GO:0051568"(histone H3-K4 methylation)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|reactome:R-HSA-381038|interpro:IPR022056|interpro:IPR037869|mint:Q9P0U4|rcsb pdb:3QMB|rcsb pdb:3QMC|rcsb pdb:3QMD|rcsb pdb:3QMG|rcsb pdb:3QMH|rcsb pdb:3QMI|refseq:NP_001095124.1|refseq:NP_055408.2|refseq:XP_011524242.1|refseq:XP_016881207.1|dip:DIP-50001N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:/cPQox/hRcR/ED//46U5w4lcsyc9606	rogid:nWwPX7OlafdCMD8Qg+hETjNkKgY9606	rigid:ozH+ANA9C3RuPdN2YBkR9BqvAso	false	sufficient binding region:305-403	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P60484	uniprotkb:Q8N1I8	intact:EBI-696162|uniprotkb:O00633|uniprotkb:O02679|uniprotkb:Q6ICT7|uniprotkb:B2R904|uniprotkb:F2YHV0|ensembl:ENSP00000361021	intact:EBI-26510006	psi-mi:pten_human(display_long)|uniprotkb:Phosphatase and tensin homolog(gene name synonym)|uniprotkb:Mutated in multiple advanced cancers 1(gene name synonym)|uniprotkb:PTEN(gene name)|psi-mi:PTEN(display_short)|uniprotkb:MMAC1(gene name synonym)|uniprotkb:TEP1(gene name synonym)	psi-mi:caas1_human(display_long)|uniprotkb:CACTIN-AS1(gene name)|psi-mi:CACTIN-AS1(display_short)|uniprotkb:C19orf29-AS1(gene name synonym)|uniprotkb:C19orf29OS(gene name synonym)|uniprotkb:Cactin antisense RNA 1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513659|imex:IM-28561-811	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000305.3|refseq:NP_001291646.2|refseq:NP_001291647.1|dip:DIP-35019N|ensembl:ENSG00000171862(gene)|ensembl:ENST00000371953(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002902"(regulation of B cell apoptotic process)|go:"GO:0004438"(phosphatidylinositol-3-phosphatase activity)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007270"(neuron-neuron synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007417"(central nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0007611"(learning or memory)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0009749"(response to glucose)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016314"(phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030534"(adult behavior)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0032286"(central nervous system myelin maintenance)|go:"GO:0032355"(response to estradiol)|go:"GO:0032535"(regulation of cellular component size)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033032"(regulation of myeloid cell apoptotic process)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0033198"(response to ATP)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035749"(myelin sheath adaxonal region)|go:"GO:0042493"|go:"GO:0042711"(maternal behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0046855"(inositol phosphate dephosphorylation)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048681"(negative regulation of axon regeneration)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051548"(negative regulation of keratinocyte migration)|go:"GO:0051717"(inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity)|go:"GO:0051800"(phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060024"(rhythmic synaptic transmission)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060074"(synapse maturation)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061002"(negative regulation of dendritic spine morphogenesis)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071257"(cellular response to electrical stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090071"(negative regulation of ribosome biogenesis)|go:"GO:0090344"(negative regulation of cell aging)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097105"(presynaptic membrane assembly)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1902807"(negative regulation of cell cycle G1/S phase transition)|go:"GO:1903690"(negative regulation of wound healing, spreading of epidermal cells)|go:"GO:1903984"(positive regulation of TRAIL-activated apoptotic signaling pathway)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000808"(negative regulation of synaptic vesicle clustering)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR014020(C2 tensin-type)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR017361(Bifunctional phosphatidylinositol trisphosphate phosphatase/dual-specificity phosphatase PTEN)|interpro:IPR029021|interpro:IPR029023|interpro:IPR035892|mint:P60484|rcsb pdb:1D5R|rcsb pdb:2KYL|rcsb pdb:4O1V|rcsb pdb:5BUG|rcsb pdb:5BZX|rcsb pdb:5BZZ|reactome:R-HSA-1660499|reactome:R-HSA-1855204|reactome:R-HSA-199418|reactome:R-HSA-202424|reactome:R-HSA-5628897|reactome:R-HSA-5674404|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-8943723|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-8986944	mint:Q8N1I8	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:/cPQox/hRcR/ED//46U5w4lcsyc9606	rogid:X91XahDyab4qIMjdYRsnTuf+Y449606	rigid:dxnbqdc6pjAMT8OGw35f2zJOx4M	false	sufficient binding region:305-403	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q7Z417	uniprotkb:P04275	intact:EBI-1210753|intact:EBI-10172018|uniprotkb:A1L3A7|uniprotkb:Q9P2M5|uniprotkb:A1L3A6|ensembl:ENSP00000225388	intact:EBI-981819|uniprotkb:Q8TCE8|uniprotkb:Q99806|ensembl:ENSP00000261405	psi-mi:nufp2_human(display_long)|uniprotkb:NUFIP2(gene name)|psi-mi:NUFIP2(display_short)|uniprotkb:KIAA1321(gene name synonym)|uniprotkb:PIG1(orf name)|uniprotkb:FMRP-interacting protein 2(gene name synonym)|uniprotkb:82 kDa FMRP-interacting protein(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 1 protein(gene name synonym)	psi-mi:vwf_human(display_long)|uniprotkb:VWF(gene name)|psi-mi:VWF(display_short)|uniprotkb:F8VWF(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513650|imex:IM-28561-809	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_065823.1|dip:DIP-29023N|ensembl:ENSG00000108256(gene)|ensembl:ENST00000225388(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0042788"(polysomal ribosome)|interpro:IPR032747|mint:Q7Z417	refseq:NP_000543.2|ensembl:ENSG00000110799(gene)|ensembl:ENST00000261405(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007155"(cell adhesion)|go:"GO:0007596"(blood coagulation)|go:"GO:0007599"(hemostasis)|go:"GO:0009611"(response to wounding)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0030168"(platelet activation)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0033093"(Weibel-Palade body)|go:"GO:0042802"(identical protein binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051087"(chaperone binding)|dip:DIP-29667N|reactome:R-HSA-9672391|reactome:R-HSA-9672393|rcsb pdb:5BV8|rcsb pdb:6FWN|rcsb pdb:6N29|rcsb pdb:7KWO|go:"GO:0062023"(collagen-containing extracellular matrix)|reactome:R-HSA-114608|reactome:R-HSA-140837|reactome:R-HSA-216083|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-430116|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-75892|reactome:R-HSA-76009|rcsb pdb:4NT5|reactome:R-HSA-9649948|reactome:R-HSA-9656223|go:"GO:1902533"(positive regulation of intracellular signal transduction)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR001846(von Willebrand factor, type D)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR002919(Protease inhibitor I8, cysteine-rich trypsin inhibitor-like)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR014853(Region of unknown function DUF1787)|interpro:IPR032361|interpro:IPR036084|interpro:IPR036465|interpro:IPR037578|mint:P04275|rcsb pdb:1AO3|rcsb pdb:1ATZ|rcsb pdb:1AUQ|rcsb pdb:1FE8|rcsb pdb:1FNS|rcsb pdb:1IJB|rcsb pdb:1IJK|rcsb pdb:1M10|rcsb pdb:1OAK|rcsb pdb:1SQ0|rcsb pdb:1U0N|rcsb pdb:1UEX|rcsb pdb:2ADF|rcsb pdb:2MHP|rcsb pdb:2MHQ|rcsb pdb:3GXB|rcsb pdb:3HXO|rcsb pdb:3HXQ|rcsb pdb:3PPV|go:"GO:0070062"(extracellular exosome)|rcsb pdb:3PPW|rcsb pdb:3PPX|rcsb pdb:3PPY|rcsb pdb:3ZQK|rcsb pdb:4C29|rcsb pdb:4C2A|rcsb pdb:4C2B|rcsb pdb:4DMU	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:zdbkRisveP+8g70umfbEPHTnAgk9606	rogid:yeGxC2SyyvUZ3hNciww1o8TmY5Q9606	rigid:I5x7kyAJXGiKDF4kHSAymMnLqn8	false	sufficient binding region:1-340	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q7Z417	uniprotkb:Q96DN2	intact:EBI-1210753|intact:EBI-10172018|uniprotkb:A1L3A7|uniprotkb:Q9P2M5|uniprotkb:A1L3A6|ensembl:ENSP00000225388	intact:EBI-2850497|uniprotkb:Q86WK8|uniprotkb:A5PKV0|uniprotkb:Q7Z7L6|ensembl:ENSP00000334186	psi-mi:nufp2_human(display_long)|uniprotkb:NUFIP2(gene name)|psi-mi:NUFIP2(display_short)|uniprotkb:KIAA1321(gene name synonym)|uniprotkb:PIG1(orf name)|uniprotkb:FMRP-interacting protein 2(gene name synonym)|uniprotkb:82 kDa FMRP-interacting protein(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 1 protein(gene name synonym)	psi-mi:vwce_human(display_long)|uniprotkb:VWCE(gene name)|psi-mi:VWCE(display_short)|uniprotkb:URG11(gene name synonym)|uniprotkb:HBV X protein up-regulated gene 11 protein(gene name synonym)|uniprotkb:HBxAg up-regulated gene 11 protein(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513641|imex:IM-28561-375	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_065823.1|dip:DIP-29023N|ensembl:ENSG00000108256(gene)|ensembl:ENST00000225388(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0042788"(polysomal ribosome)|interpro:IPR032747|mint:Q7Z417	refseq:NP_689931.2|ensembl:ENSG00000167992(gene)|ensembl:ENST00000335613(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0098586"(cellular response to virus)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR018097|mint:Q96DN2	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:zdbkRisveP+8g70umfbEPHTnAgk9606	rogid:iBs6xSgpnuM95cf8NssaHvB9bSI9606	rigid:bq6s5wfaR2pcjLxYvsro0k88Pvs	false	sufficient binding region:1-340	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q7Z417	uniprotkb:Q8N3V7	intact:EBI-1210753|intact:EBI-10172018|uniprotkb:A1L3A7|uniprotkb:Q9P2M5|uniprotkb:A1L3A6|ensembl:ENSP00000225388	intact:EBI-352936|intact:EBI-28982054|ensembl:ENSP00000377789|ensembl:ENSP00000428378|uniprotkb:O15271|uniprotkb:Q9UPX1|uniprotkb:A5PKZ8|uniprotkb:D3DQG8	psi-mi:nufp2_human(display_long)|uniprotkb:NUFIP2(gene name)|psi-mi:NUFIP2(display_short)|uniprotkb:KIAA1321(gene name synonym)|uniprotkb:PIG1(orf name)|uniprotkb:FMRP-interacting protein 2(gene name synonym)|uniprotkb:82 kDa FMRP-interacting protein(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 1 protein(gene name synonym)	psi-mi:synpo_human(display_long)|uniprotkb:SYNPO(gene name)|psi-mi:SYNPO(display_short)|uniprotkb:KIAA1029(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513632|imex:IM-28561-807	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_065823.1|dip:DIP-29023N|ensembl:ENSG00000108256(gene)|ensembl:ENST00000225388(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0042788"(polysomal ribosome)|interpro:IPR032747|mint:Q7Z417	ensembl:ENSG00000171992(gene)|ensembl:ENST00000394243(transcript)|ensembl:ENST00000522122(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030018"(Z disc)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0097444"(spine apparatus)|go:"GO:1905355"(spine apparatus assembly)|interpro:IPR028753|mint:Q8N3V7|go:"GO:0098886"(modification of dendritic spine)|refseq:NP_001103444.1|refseq:NP_001159680.1|refseq:NP_001159681.1|refseq:NP_009217.3|ensembl:ENST00000307662|ensembl:ENSP00000302139|ensembl:ENSP00000377789|ensembl:ENST00000519664|ensembl:ENSP00000429268|ensembl:ENSP00000428378|refseq:XP_011535854.1|refseq:XP_005268427.1|refseq:XP_005268428.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:zdbkRisveP+8g70umfbEPHTnAgk9606	rogid:rCCRVthnF+JTqcwh9lD+GFoWIpo9606	rigid:gcP8C6E9kKsFCFwXP+ahzW+8+T0	false	sufficient binding region:1-340	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q7Z417	uniprotkb:Q9H169	intact:EBI-1210753|intact:EBI-10172018|uniprotkb:A1L3A7|uniprotkb:Q9P2M5|uniprotkb:A1L3A6|ensembl:ENSP00000225388	intact:EBI-722971|uniprotkb:B7Z2Z7|uniprotkb:Q2TAB9|uniprotkb:D3DSS8|uniprotkb:D3DSS9|uniprotkb:B7Z4I9|uniprotkb:G5EA16|ensembl:ENSP00000265770	psi-mi:nufp2_human(display_long)|uniprotkb:NUFIP2(gene name)|psi-mi:NUFIP2(display_short)|uniprotkb:KIAA1321(gene name synonym)|uniprotkb:PIG1(orf name)|uniprotkb:FMRP-interacting protein 2(gene name synonym)|uniprotkb:82 kDa FMRP-interacting protein(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 1 protein(gene name synonym)	psi-mi:stmn4_human(display_long)|uniprotkb:Stathmin-like protein B3(gene name synonym)|uniprotkb:STMN4(gene name)|psi-mi:STMN4(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513623|imex:IM-28561-1723	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_065823.1|dip:DIP-29023N|ensembl:ENSG00000108256(gene)|ensembl:ENST00000225388(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0042788"(polysomal ribosome)|interpro:IPR032747|mint:Q7Z417	refseq:NP_001269983.1|refseq:NP_110422.2|refseq:NP_001269982.1|refseq:NP_001269984.1|ensembl:ENSG00000015592(gene)|ensembl:ENST00000265770(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0007019"(microtubule depolymerization)|go:"GO:0015631"(tubulin binding)|go:"GO:0030426"(growth cone)|go:"GO:0031110"(regulation of microtubule polymerization or depolymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0043005"(neuron projection)|interpro:IPR000956(Stathmin)|interpro:IPR028834|interpro:IPR030514|interpro:IPR036002|mint:Q9H169|rcsb pdb:6BR1|rcsb pdb:6BRF|rcsb pdb:6BRY|rcsb pdb:6NNG|rcsb pdb:6O5M|rcsb pdb:6O5N|rcsb pdb:6O61|rcsb pdb:6PC4	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:zdbkRisveP+8g70umfbEPHTnAgk9606	rogid:Nz8GpnGi0yiq5hg9L9dn/eI10ag9606	rigid:1D0wio12P87Mks8m6I4LIAEU1wk	false	sufficient binding region:1-340	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q7Z417	uniprotkb:Q9NY15	intact:EBI-1210753|intact:EBI-10172018|uniprotkb:A1L3A7|uniprotkb:Q9P2M5|uniprotkb:A1L3A6|ensembl:ENSP00000225388	intact:EBI-2797815|uniprotkb:Q93072|uniprotkb:Q8IUH1|uniprotkb:Q8IUH0|uniprotkb:A7E297|ensembl:ENSP00000312946	psi-mi:nufp2_human(display_long)|uniprotkb:NUFIP2(gene name)|psi-mi:NUFIP2(display_short)|uniprotkb:KIAA1321(gene name synonym)|uniprotkb:PIG1(orf name)|uniprotkb:FMRP-interacting protein 2(gene name synonym)|uniprotkb:82 kDa FMRP-interacting protein(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 1 protein(gene name synonym)	psi-mi:stab1_human(display_long)|uniprotkb:Fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavenger receptor 1(gene name synonym)|uniprotkb:MS-1 antigen(gene name synonym)|uniprotkb:FEEL1(gene name synonym)|uniprotkb:KIAA0246(gene name synonym)|uniprotkb:STAB1(gene name)|psi-mi:STAB1(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513614|imex:IM-28561-1259	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_065823.1|dip:DIP-29023N|ensembl:ENSG00000108256(gene)|ensembl:ENST00000225388(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0042788"(polysomal ribosome)|interpro:IPR032747|mint:Q7Z417	refseq:NP_055951.2|ensembl:ENSG00000010327(gene)|ensembl:ENST00000321725(transcript)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005540"(hyaluronic acid binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0042742"(defense response to bacterium)|interpro:IPR000538(Link)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000782(Beta-Ig-H3/fasciclin)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002049(EGF-like, laminin)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR024731|interpro:IPR036378|mint:Q9NY15|reactome:R-HSA-3000497|go:"GO:0030169"(low-density lipoprotein particle binding)	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:zdbkRisveP+8g70umfbEPHTnAgk9606	rogid:Y+QVppJrqNJEd2E6wtHqFT+1cII9606	rigid:5nk/s9d9RTj66ouo+ItHIfAVrFY	false	sufficient binding region:1-340	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q7Z417	uniprotkb:O43597	intact:EBI-1210753|intact:EBI-10172018|uniprotkb:A1L3A7|uniprotkb:Q9P2M5|uniprotkb:A1L3A6|ensembl:ENSP00000225388	intact:EBI-742487|uniprotkb:Q5T6Z7|ensembl:ENSP00000366306|ensembl:ENSP00000366308|uniprotkb:B2R9J9	psi-mi:nufp2_human(display_long)|uniprotkb:NUFIP2(gene name)|psi-mi:NUFIP2(display_short)|uniprotkb:KIAA1321(gene name synonym)|uniprotkb:PIG1(orf name)|uniprotkb:FMRP-interacting protein 2(gene name synonym)|uniprotkb:82 kDa FMRP-interacting protein(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 1 protein(gene name synonym)	psi-mi:spy2_human(display_long)|uniprotkb:SPRY2(gene name)|psi-mi:SPRY2(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513605|imex:IM-28561-805	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_065823.1|dip:DIP-29023N|ensembl:ENSG00000108256(gene)|ensembl:ENST00000225388(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0042788"(polysomal ribosome)|interpro:IPR032747|mint:Q7Z417	refseq:NP_005833.1|rcsb pdb:5HL0|reactome:R-HSA-1295596|reactome:R-HSA-182971|rcsb pdb:5HKZ|ensembl:ENST00000377102(transcript)|ensembl:ENST00000377104(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|ensembl:ENSG00000136158(gene)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030291"(protein serine/threonine kinase inhibitor activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031345"(negative regulation of cell projection organization)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045165"(cell fate commitment)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048513"(animal organ development)|go:"GO:0051387"(negative regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060437"(lung growth)|go:"GO:0060449"(bud elongation involved in lung branching)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:1900747"(negative regulation of vascular endothelial growth factor signaling pathway)|go:"GO:1902747"(negative regulation of lens fiber cell differentiation)|go:"GO:1990752"(microtubule end)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR007875(Sprouty)|interpro:IPR030780|mint:O43597|rcsb pdb:3BUM|rcsb pdb:3OB1|rcsb pdb:5HKY|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|refseq:NP_001305465.1|refseq:NP_001305466.1|refseq:NP_001305467.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:zdbkRisveP+8g70umfbEPHTnAgk9606	rogid:u1omauzisc6MdZlogMotUmtauSI9606	rigid:pc6K02ASDX8idXrwdyC96J4AZfE	false	sufficient binding region:1-340	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:P12814	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-351710|uniprotkb:Q9BTN1|uniprotkb:Q1HE25|uniprotkb:B7TY16|intact:EBI-3866221|uniprotkb:B3V8S3|uniprotkb:B4DHH3|ensembl:ENSP00000193403	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:actn1_human(display_long)|uniprotkb:ACTN1(gene name)|psi-mi:ACTN1(display_short)|uniprotkb:Alpha-actinin cytoskeletal isoform(gene name synonym)|uniprotkb:Non-muscle alpha-actinin-1(gene name synonym)|uniprotkb:F-actin cross-linking protein(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513749|imex:IM-28561-1269	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_001093.1|refseq:NP_001123477.1|refseq:NP_001123476.1|dip:DIP-33184N|ensembl:ENSG00000072110(gene)|ensembl:ENST00000193403(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005916"(fascia adherens)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0017166"(vinculin binding)|go:"GO:0030018"(Z disc)|go:"GO:0030220"(platelet formation)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031143"(pseudopodium)|go:"GO:0036344"(platelet morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0042995"(cell projection)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051271"(negative regulation of cellular component movement)|go:"GO:0051639"(actin filament network formation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099186"(structural constituent of postsynapse)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR018247|interpro:IPR036872|mint:P12814|rcsb pdb:2EYI|rcsb pdb:2EYN|rcsb pdb:2N8Y|rcsb pdb:2N8Z|reactome:R-HSA-114608|reactome:R-HSA-3000170|reactome:R-HSA-373753|reactome:R-HSA-446388|reactome:R-HSA-9013405|reactome:R-HSA-9013418|reactome:R-HSA-9035034	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:guTURyt26f1ort4NAlYyabNc+WE9606	rigid:OL2TG7jx2hHyhhVBBiahfBrX0KQ	false	sufficient binding region:791-1222	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:P54259	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-945980|uniprotkb:Q99495|uniprotkb:Q99621|uniprotkb:Q9UEK7|ensembl:ENSP00000349076|ensembl:ENSP00000379915	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:atn1_human(display_long)|uniprotkb:ATN1(gene name)|psi-mi:ATN1(display_short)|uniprotkb:DRPLA(gene name synonym)|uniprotkb:Dentatorubral-pallidoluysian atrophy protein(gene name synonym)|uniprotkb:D12S755E(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513830|imex:IM-28561-159	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_001007027.1|refseq:NP_001931.2|ensembl:ENSP00000349076|ensembl:ENSP00000379915|dip:DIP-29423N|ensembl:ENSG00000111676(gene)|ensembl:ENST00000356654(transcript)|ensembl:ENST00000396684(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0007417"(central nervous system development)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030054"(cell junction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|interpro:IPR002951(Atrophin)|interpro:IPR017993|mint:P54259|reactome:R-HSA-8943724	-	-	crc64:B47603486C672637	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:SX8MuZ4aW8/PJmQl4HqY+NOSxbI9606	rigid:0gmyVm+HusmHBPAiTbrpqNefGto	false	sufficient binding region:791-1222	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q9UQB8	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-525456|uniprotkb:O43858|uniprotkb:Q53HB1|uniprotkb:Q86WC1|uniprotkb:Q8N5C0|uniprotkb:Q96CR7|uniprotkb:Q9UBR3|uniprotkb:Q9UQ43|ensembl:ENSP00000316338	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:baip2_human(display_long)|uniprotkb:Insulin receptor substrate protein of 53 kDa(gene name synonym)|uniprotkb:Insulin receptor substrate p53/p58(gene name synonym)|uniprotkb:Fas ligand-associated factor 3(gene name synonym)|uniprotkb:BAIAP2(gene name)|psi-mi:BAIAP2(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513839|imex:IM-28561-813	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_001138360.1|refseq:NP_006331.1|refseq:NP_059344.1|refseq:NP_059345.1|refseq:XP_005257005.1|dip:DIP-29272N|go:"GO:0009617"(response to bacterium)|go:"GO:0016358"(dendrite development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030141"(secretory granule)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030175"(filopodium)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051764"(actin crosslink formation)|go:"GO:0060076"(excitatory synapse)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061845"(neuron projection branch point)|go:"GO:0061846"(dendritic spine cytoplasm)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099564"(modification of synaptic structure, modulating synaptic transmission)|go:"GO:1905232"(cellular response to L-glutamate)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR001452(Src homology-3)|interpro:IPR013606("IRSp53/MIM homology domain (IMD)")|interpro:IPR027267|interpro:IPR027681|interpro:IPR030128|interpro:IPR035594|interpro:IPR036028|mint:Q9UQB8|rcsb pdb:1WDZ|rcsb pdb:1Y2O|rcsb pdb:2YKT|rcsb pdb:3RNJ|rcsb pdb:4JS0|rcsb pdb:6BCR|rcsb pdb:6BCY|rcsb pdb:6BD1|rcsb pdb:6BD2|rcsb pdb:6BQT|rcsb pdb:6ZEG|rcsb pdb:6ZEI|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013423|reactome:R-HSA-9664422|ensembl:ENSG00000175866(gene)|ensembl:ENST00000321300(transcript)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001726"(ruffle)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007409"(axonogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008093"(cytoskeletal anchor activity)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008360"(regulation of cell shape)	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:BRbjAYBnAJN0Pzb7bc/Qtb4w5bY9606	rigid:ZL97Omofs2F7yq6OTuj+KnbptgI	false	sufficient binding region:791-1222	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:O15144	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-352356|uniprotkb:Q92801|uniprotkb:Q9P1D4|ensembl:ENSP00000295685|ensembl:ENSP00000327137	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:arpc2_human(display_long)|uniprotkb:ARPC2(gene name)|psi-mi:ARPC2(display_short)|uniprotkb:ARC34(gene name synonym)|uniprotkb:PRO2446(orf name)|uniprotkb:Arp2/3 complex 34 kDa subunit(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513812|imex:IM-28561-157	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_005722.1|refseq:NP_690601.1|go:"GO:0005925"(focal adhesion)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030027"(lamellipodium)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0034314"(Arp2/3 complex-mediated actin nucleation)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036195"(muscle cell projection membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070358"(actin polymerization-dependent cell motility)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|interpro:IPR007188(Arp2/3 complex, 34kDa subunit p34-Arc)|interpro:IPR034666|mint:O15144|rcsb pdb:6UHC|rcsb pdb:6YW6|rcsb pdb:6YW7|reactome:R-HSA-2029482|go:"GO:0005885"(Arp2/3 protein complex)|reactome:R-HSA-5663213|reactome:R-HSA-8856828|reactome:R-HSA-9664422|reactome:R-HSA-3928662|ensembl:ENSG00000163466(gene)|ensembl:ENST00000295685(transcript)|ensembl:ENST00000315717(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|dip:DIP-33197N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:v5OozQTt614rvrBBoUavbAzjgZ49606	rigid:8JpgSy2UuK7ES09YAQsJNGSWI9E	false	sufficient binding region:791-1222	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q14155	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-717515|uniprotkb:B1ALK6|uniprotkb:B1ALK8|uniprotkb:Q3LIA4|uniprotkb:Q5W9H0|uniprotkb:Q6P9G3|uniprotkb:Q6PII2|uniprotkb:Q86W63|uniprotkb:Q8N3M1|ensembl:ENSP00000364893	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:arhg7_human(display_long)|uniprotkb:PAK-interacting exchange factor beta(gene name synonym)|uniprotkb:Beta-Pix(gene name synonym)|uniprotkb:COOL-1(gene name synonym)|uniprotkb:p85(gene name synonym)|uniprotkb:Nbla10314(orf name)|uniprotkb:ARHGEF7(gene name)|psi-mi:ARHGEF7(display_short)|uniprotkb:COOL1(gene name synonym)|uniprotkb:KIAA0142(gene name synonym)|uniprotkb:P85SPR(gene name synonym)|uniprotkb:PAK3BP(gene name synonym)|uniprotkb:PIXB(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513803|imex:IM-28561-1731	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_001307782.1|refseq:NP_663788.1|refseq:NP_001106983.1|refseq:NP_001106984.1|refseq:NP_001106985.1|refseq:NP_001307780.1|refseq:NP_001307783.1|refseq:NP_001317526.1|refseq:NP_001317527.1|ensembl:ENSG00000102606(gene)|ensembl:ENST00000375741(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0007030"(Golgi organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0005925"(focal adhesion)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043005"(neuron projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0098794"(postsynapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1904424"(regulation of GTP binding)|go:"GO:1905833"(negative regulation of microtubule nucleation)|go:"GO:2000394"(positive regulation of lamellipodium morphogenesis)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035789|interpro:IPR035899|interpro:IPR036028|interpro:IPR036872|mint:Q14155|rcsb pdb:1BY1|rcsb pdb:1ZSG|rcsb pdb:2L3G|rcsb pdb:5SXP|reactome:R-HSA-182971|reactome:R-HSA-193648|reactome:R-HSA-3928664|reactome:R-HSA-416482|reactome:R-HSA-8980692|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013406|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-9013424|reactome:R-HSA-9619229|dip:DIP-40794N|refseq:NP_003890.1|refseq:XP_016876313.1|refseq:XP_016876314.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:0I59YglGXcYP7fFKIAWM6uCZY8Q9606	rigid:ik6io8OpseFovYPjR6YIslsKQ4g	false	sufficient binding region:374-740	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:P05067	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-77613|uniprotkb:P09000|uniprotkb:P78438|uniprotkb:Q13764|uniprotkb:Q13778|uniprotkb:Q13793|ensembl:ENSP00000284981|intact:EBI-28985182|uniprotkb:Q6GSC0|uniprotkb:Q8WZ99|uniprotkb:Q9UC33|uniprotkb:Q9UCC8|uniprotkb:Q9UCD1|uniprotkb:Q9UQ58|uniprotkb:Q16011|uniprotkb:Q16014|uniprotkb:Q16019|uniprotkb:Q16020|uniprotkb:Q9BT38|uniprotkb:Q9UCA9|uniprotkb:Q9UCB6|uniprotkb:B4DII8|uniprotkb:B2R5V1|uniprotkb:D3DSD1|uniprotkb:D3DSD2|uniprotkb:D3DSD3	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:a4_human(display_long)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513794|imex:IM-28561-1055	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	go:"GO:0097645"(amylin binding)|go:"GO:0098815"(modulation of excitatory postsynaptic potential)|go:"GO:0106003"(amyloid-beta complex)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:1900122"(positive regulation of receptor binding)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:1900221"(regulation of amyloid-beta clearance)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903048"(regulation of acetylcholine-gated cation channel activity)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903523"(negative regulation of blood circulation)|go:"GO:1904022"(positive regulation of G protein-coupled receptor internalization)|go:"GO:0035253"(ciliary rootlet)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043235"(receptor complex)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044304"(main axon)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0046914"(transition metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|ensembl:ENST00000346798(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|ensembl:ENSG00000142192(gene)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001878"(response to yeast)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001967"(suckling behavior)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0006417"(regulation of translation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007155"(cell adhesion)|go:"GO:0007176"(regulation of epidermal growth factor-activated receptor activity)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007409"(axonogenesis)|go:"GO:0007611"(learning or memory)|go:"GO:0006897"(endocytosis)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007617"(mating behavior)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008088"(axo-dendritic transport)|go:"GO:0008201"(heparin binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0009987"(cellular process)|go:"GO:0010288"(response to lead ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010739"(positive regulation of protein kinase A signaling)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048669"(collateral sprouting in absence of injury)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0050786"(RAGE receptor binding)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050808"(synapse organization)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050867"(positive regulation of cell activation)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0050890"(cognition)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051087"(chaperone binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051124"(synaptic assembly at neuromuscular junction)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0010823"(negative regulation of mitochondrion organization)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0014005"(microglia development)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016199"(axon midline choice point recognition)|go:"GO:0016322"(neuron remodeling)|go:"GO:0016358"(dendrite development)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019899"(enzyme binding)|go:"GO:0030111"(regulation of Wnt signaling pathway)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030424"(axon)|go:"GO:0030546"(signaling receptor activator activity)|go:"GO:0030549"(acetylcholine receptor activator activity)|go:"GO:0030900"(forebrain development)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031175"(neuron projection development)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034121"(regulation of toll-like receptor signaling pathway)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034363"(intermediate-density lipoprotein particle)|go:"GO:0034364"(high-density lipoprotein particle)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0031904"(endosome lumen)|go:"GO:0051233"(spindle midzone)|go:"GO:0061903"(positive regulation of 1-phosphatidylinositol-3-kinase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0070206"(protein trimerization)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070381"(endosome to plasma membrane transport vesicle)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071874"(cellular response to norepinephrine stimulus)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0097449"(astrocyte projection)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051425"(PTB domain binding)|go:"GO:0051563"(smooth endoplasmic reticulum calcium ion homeostasis)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:1904399"(heparan sulfate binding)|rcsb pdb:2LZ4|rcsb pdb:2M4J|rcsb pdb:2M9R|rcsb pdb:2M9S|rcsb pdb:2MGT|rcsb pdb:2MJ1|rcsb pdb:2MPZ|rcsb pdb:2MVX|rcsb pdb:2MXU|rcsb pdb:2NAO|interpro:IPR036880|interpro:IPR037071|rcsb pdb:2OTK|rcsb pdb:2R0W|rcsb pdb:2WK3|rcsb pdb:2Y29|mint:P05067|rcsb pdb:1AAP|rcsb pdb:1AMB|rcsb pdb:1AMC|rcsb pdb:1AML|rcsb pdb:1BA4|rcsb pdb:1BA6|rcsb pdb:1BJB|rcsb pdb:1BJC|rcsb pdb:1BRC|rcsb pdb:1CA0|rcsb pdb:1HZ3|rcsb pdb:1IYT|rcsb pdb:1MWP|rcsb pdb:1OWT|rcsb pdb:1QCM|rcsb pdb:1QWP|rcsb pdb:1QXC|rcsb pdb:1QYT|rcsb pdb:1TAW|rcsb pdb:1TKN|rcsb pdb:1UO7|rcsb pdb:1UO8|rcsb pdb:1UOA|rcsb pdb:1UOI|rcsb pdb:1X11|rcsb pdb:1Z0Q|rcsb pdb:1ZE7|rcsb pdb:1ZE9|rcsb pdb:1ZJD|rcsb pdb:2BEG|rcsb pdb:2BOM|rcsb pdb:2BP4|rcsb pdb:2FJZ|rcsb pdb:2FK1|rcsb pdb:2FK2|rcsb pdb:2FK3|rcsb pdb:2FKL|rcsb pdb:2FMA|rcsb pdb:2G47|rcsb pdb:2IPU|rcsb pdb:2LFM|rcsb pdb:2LLM|rcsb pdb:2LMN|rcsb pdb:2LMO|rcsb pdb:2LMP|rcsb pdb:2LMQ|rcsb pdb:2LNQ|rcsb pdb:2LOH|rcsb pdb:2LP1|rcsb pdb:2LZ3|rcsb pdb:2Y2A|rcsb pdb:2Y3J|rcsb pdb:2Y3K|rcsb pdb:2Y3L|rcsb pdb:3AYU|rcsb pdb:3BAE|rcsb pdb:3BKJ|rcsb pdb:3DXC|rcsb pdb:3DXD|rcsb pdb:3DXE|rcsb pdb:3GCI|rcsb pdb:3IFL|rcsb pdb:3IFN|rcsb pdb:3IFO|rcsb pdb:3IFP|rcsb pdb:3JQ5|rcsb pdb:3JQL|rcsb pdb:3JTI|rcsb pdb:3KTM|rcsb pdb:3L33|go:"GO:1904472"(positive regulation of endothelin production)|go:"GO:1904591"(positive regulation of protein import)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905606"(regulation of presynapse assembly)|go:"GO:1905893"(positive regulation of cellular response to thapsigargin)|go:"GO:1905896"(positive regulation of cellular response to tunicamycin)|go:"GO:1905898"(positive regulation of response to endoplasmic reticulum stress)|go:"GO:1905906"(regulation of amyloid fibril formation)|go:"GO:1905908"(positive regulation of amyloid fibril formation)|go:"GO:1905945"(regulation of response to calcium ion)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990535"(neuron projection maintenance)|go:"GO:1990761"(growth cone lamellipodium)|go:"GO:1990777"(lipoprotein particle)|go:"GO:1990812"(growth cone filopodium)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR002223(Proteinase inhibitor I2, Kunitz metazoa)|interpro:IPR008154(Amyloidogenic glycoprotein, extracellular)|interpro:IPR008155(Amyloidogenic glycoprotein, core)|interpro:IPR011178(Amyloidogenic glycoprotein, copper-binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013803(Amyloidogenic glycoprotein, amyloid-beta peptide)|interpro:IPR015849(Amyloidogenic glycoprotein, heparin-binding)|interpro:IPR019543|interpro:IPR019744|interpro:IPR019745|interpro:IPR020901|interpro:IPR024329|interpro:IPR028866|interpro:IPR036176|interpro:IPR036454|interpro:IPR036669|rcsb pdb:5HOY|rcsb pdb:5KK3|rcsb pdb:5LFY|rcsb pdb:5LV0|rcsb pdb:5MY4|rcsb pdb:5MYO|rcsb pdb:5MYX|rcsb pdb:5ONP|rcsb pdb:5ONQ|rcsb pdb:5OQV|rcsb pdb:5TXD|rcsb pdb:5VOS|rcsb pdb:5VZY|rcsb pdb:5W3P|rcsb pdb:6CO3|rcsb pdb:6GFI|rcsb pdb:6ITU|rcsb pdb:6IYC|rcsb pdb:6NB9|rcsb pdb:6O4J|rcsb pdb:6OC9|rcsb pdb:6OIZ|rcsb pdb:6RHY|rcsb pdb:6SHS|rcsb pdb:6SZF|rcsb pdb:6TI5|rcsb pdb:6TI6|rcsb pdb:6TI7|rcsb pdb:6W0O|rcsb pdb:6WXM|rcsb pdb:6YHF|rcsb pdb:6YHI|rcsb pdb:6YHO|rcsb pdb:6YHP|rcsb pdb:6YHX|rcsb pdb:7B3J|rcsb pdb:7B3K|rcsb pdb:7JXN|rcsb pdb:7JXO|rcsb pdb:7O1Q|reactome:R-HSA-114608|reactome:R-HSA-3000178|reactome:R-HSA-381426|reactome:R-HSA-416476|reactome:R-HSA-418594|reactome:R-HSA-432720|reactome:R-HSA-444473|reactome:R-HSA-445989|reactome:R-HSA-844456|reactome:R-HSA-879415|reactome:R-HSA-8862803|reactome:R-HSA-8957275|reactome:R-HSA-933542|reactome:R-HSA-9609523|reactome:R-HSA-9660826|reactome:R-HSA-977225|rcsb pdb:5AMB|rcsb pdb:5BUO|rcsb pdb:5C67|rcsb pdb:5CSZ|rcsb pdb:5HOW|rcsb pdb:5HOX|rcsb pdb:3L81|rcsb pdb:3MOQ|rcsb pdb:3MXC|rcsb pdb:3MXY|rcsb pdb:3NYJ|rcsb pdb:3NYL|rcsb pdb:3OVJ|rcsb pdb:3OW9|rcsb pdb:3PZZ|rcsb pdb:3Q2X|rcsb pdb:3SV1|rcsb pdb:3U0T|rcsb pdb:3UMH|rcsb pdb:3UMI|rcsb pdb:3UMK|rcsb pdb:4HIX|rcsb pdb:4JFN|rcsb pdb:4M1C|rcsb pdb:4MDR|rcsb pdb:4MVI|rcsb pdb:4MVK|rcsb pdb:4MVL|rcsb pdb:4NGE|rcsb pdb:4OJF|rcsb pdb:4ONF|rcsb pdb:4ONG|rcsb pdb:4PQD|rcsb pdb:4PWQ|rcsb pdb:4XXD|rcsb pdb:5AEF|rcsb pdb:5AM8|refseq:NP_000475.1|refseq:NP_001129601.1|refseq:NP_001129602.1|refseq:NP_001191230.1|refseq:NP_001191231.1|refseq:NP_001191232.1|refseq:NP_958816.1|refseq:NP_958817.1|ensembl:ENSP00000284981|ensembl:ENST00000348990|ensembl:ENSP00000345463|ensembl:ENST00000354192|ensembl:ENSP00000346129|ensembl:ENST00000357903|ensembl:ENSP00000350578|ensembl:ENST00000358918|ensembl:ENSP00000351796|ensembl:ENST00000440126|ensembl:ENSP00000387483|refseq:NP_001129488.1|refseq:NP_001129603.1|dip:DIP-574N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:HatR8w8+mNjtjr7s5+bAwaStpmk9606	rigid:nvSSori3PGqLxoaADmxuQBZf/9M	false	sufficient binding region:791-1222	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q8N283	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-2813523|uniprotkb:B4DL62|uniprotkb:A6NEU0|uniprotkb:Q3MJ10|uniprotkb:Q96LS3|ensembl:ENSP00000347802	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:anr35_human(display_long)|uniprotkb:ANKRD35(gene name)|psi-mi:ANKRD35(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513785|imex:IM-28561-379	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	ensembl:ENSG00000198483(gene)|ensembl:ENST00000355594(transcript)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|mint:Q8N283|refseq:NP_653299.4	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:gKpYjof24pm0XACs5Co0Kuu5gXc9606	rigid:nl/mqqfrF5Y7T/aGRUlNMuKIYVY	false	sufficient binding region:1219-1731	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:P04075	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-709613|uniprotkb:Q6FH76|uniprotkb:Q96B15|uniprotkb:Q9BWD9|uniprotkb:B4DXI7|uniprotkb:Q6FI10|uniprotkb:Q9UCN2|ensembl:ENSP00000400452|ensembl:ENSP00000455700|ensembl:ENSP00000455800|ensembl:ENSP00000494188	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:aldoa_human(display_long)|uniprotkb:Muscle-type aldolase(gene name synonym)|uniprotkb:Lung cancer antigen NY-LU-1(gene name synonym)|uniprotkb:ALDOA(gene name)|psi-mi:ALDOA(display_short)|uniprotkb:ALDA(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513776|imex:IM-28561-1515	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_000025.1|refseq:NP_001121089.1|refseq:NP_001230106.1|refseq:NP_908930.1|refseq:NP_908932.1|refseq:XP_011544070.1|ensembl:ENSG00000149925(gene)|ensembl:ENST00000412304(transcript)|ensembl:ENST00000563060(transcript)|ensembl:ENST00000569545(transcript)|ensembl:ENST00000643777(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004332"(fructose-bisphosphate aldolase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006000"(fructose metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0006941"(striated muscle contraction)|go:"GO:0007015"(actin filament organization)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0015631"(tubulin binding)|go:"GO:0016020"(membrane)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031430"(M band)|go:"GO:0031674"(I band)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0061827"(sperm head)|go:"GO:0070061"(fructose binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000741(Fructose-bisphosphate aldolase, class-I)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR029768|mint:P04075|rcsb pdb:1ALD|rcsb pdb:2ALD|rcsb pdb:4ALD|rcsb pdb:5KY6|reactome:R-HSA-114608|reactome:R-HSA-6798695|reactome:R-HSA-70171|reactome:R-HSA-70263	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:/UgTtKPQj2ZyKznKIfE9OVUcDFI9606	rigid:/G1RUiqc6B7SbKtJqwfU9V6pATo	false	sufficient binding region:374-740	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q5VUJ5	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-6870855|intact:EBI-28973493|uniprotkb:A6NGH4	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:agap7_human(display_long)|uniprotkb:AGAP7P(gene name)|psi-mi:AGAP7P(display_short)|uniprotkb:AGAP7(gene name synonym)|uniprotkb:Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 7 pseudogene(gene name synonym)|uniprotkb:CTGLF4(gene name synonym)|uniprotkb:Centaurin-gamma-like family member 4(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513767|imex:IM-28561-601	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	mint:Q5VUJ5|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0046872"(metal ion binding)|interpro:IPR038508|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|interpro:IPR037278	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:DQH6ZZBczIlxcThYPThO0fnjjW49606	rigid:1Eisc0lA4IaL2VzShAJV20bXGn0	false	sufficient binding region:374-740	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q9P1A6	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-1753397|uniprotkb:A1QCF8|uniprotkb:A1QCF9|uniprotkb:A5D8Y2|uniprotkb:O14488|uniprotkb:O14664|uniprotkb:Q9P1A7|intact:EBI-28975795|ensembl:ENSP00000400258	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:dlgp2_human(display_long)|uniprotkb:DLGAP2(gene name)|psi-mi:DLGAP2(display_short)|uniprotkb:DAP2(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 2(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 2(gene name synonym)|uniprotkb:C8orf68(gene name synonym)|uniprotkb:ERICH1-AS1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514037|imex:IM-28561-821	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	ensembl:ENSP00000400258|refseq:NP_004736.2|ensembl:ENSG00000198010(gene)|ensembl:ENST00000421627(transcript)|go:"GO:0005883"(neurofilament)|go:"GO:0005886"(plasma membrane)|go:"GO:0007270"(neuron-neuron synaptic transmission)|go:"GO:0014069"(postsynaptic density)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030525|mint:Q9P1A6|reactome:R-HSA-6794361	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:pX0NGC6caBQfddORrXz3keCGf109606	rigid:assLkDSkuoUTJZIbDq0W+HNIeCk	false	sufficient binding region:374-740	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:O14490	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-1753207|uniprotkb:O14489|uniprotkb:P78335|uniprotkb:B2RMU8|uniprotkb:B7WPA1|uniprotkb:A8MWN8|uniprotkb:B7Z2H2|uniprotkb:B7Z2I2|uniprotkb:B7Z9Y4|ensembl:ENSP00000316377	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:dlgp1_human(display_long)|uniprotkb:DLGAP1(gene name)|psi-mi:DLGAP1(display_short)|uniprotkb:DAP1(gene name synonym)|uniprotkb:GKAP(gene name synonym)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514028|imex:IM-28561-1289	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_001003809.1|refseq:NP_001229690.1|refseq:NP_001229691.1|refseq:NP_001229692.1|refseq:NP_001229693.1|refseq:NP_001229694.1|refseq:NP_001229695.1|refseq:NP_004737.2|ensembl:ENSG00000170579(gene)|ensembl:ENST00000315677(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0014069"(postsynaptic density)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:O14490|rcsb pdb:5YPO|rcsb pdb:6TNQ|rcsb pdb:6TQ0|reactome:R-HSA-6794361	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:fGISLkYSlOD5ioIPFU8bVuBObMg9606	rigid:XegURNnCOE/rYC6gvBCKPad48TI	false	sufficient binding region:374-740	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q16531	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-350322|uniprotkb:A6NG77|uniprotkb:O15176|uniprotkb:Q13289|ensembl:ENSP00000301764|ensembl:ENSP00000506223|ensembl:ENSP00000506685|uniprotkb:Q58F96|uniprotkb:B2R648|uniprotkb:B4DG00	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:ddb1_human(display_long)|uniprotkb:DDB1(gene name)|psi-mi:DDB1(display_short)|uniprotkb:Damage-specific DNA-binding protein 1(gene name synonym)|uniprotkb:UV-damaged DNA-binding factor(gene name synonym)|uniprotkb:DDB p127 subunit(gene name synonym)|uniprotkb:DNA damage-binding protein a(gene name synonym)|uniprotkb:UV-damaged DNA-binding protein 1(gene name synonym)|uniprotkb:Xeroderma pigmentosum group E-complementing protein(gene name synonym)|uniprotkb:XPE-binding factor(gene name synonym)|uniprotkb:HBV X-associated protein 1(gene name synonym)|uniprotkb:XAP1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514019|imex:IM-28561-387	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_001914.3|rcsb pdb:3I89|rcsb pdb:3I8C|rcsb pdb:3I8E|rcsb pdb:4A08|rcsb pdb:4A09|rcsb pdb:4A0A|rcsb pdb:4A0B|rcsb pdb:4A0K|rcsb pdb:4A0L|rcsb pdb:4A11|rcsb pdb:4CI1|rcsb pdb:4CI2|rcsb pdb:4CI3|rcsb pdb:4E54|rcsb pdb:4E5Z|rcsb pdb:4TZ4|rcsb pdb:5FQD|rcsb pdb:5HXB|rcsb pdb:5JK7|rcsb pdb:5V3O|rcsb pdb:6BN7|ensembl:ENSG00000167986(gene)|ensembl:ENST00000301764(transcript)|ensembl:ENST00000680367(transcript)|ensembl:ENST00000681803(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030674"(protein-macromolecule adaptor activity)|rcsb pdb:6BN8|rcsb pdb:6BN9|rcsb pdb:6BNB|rcsb pdb:6BOY|rcsb pdb:6DSZ|rcsb pdb:6FCV|rcsb pdb:6H0F|rcsb pdb:6H0G|rcsb pdb:6PAI|rcsb pdb:6Q0R|rcsb pdb:6Q0V|rcsb pdb:6Q0W|rcsb pdb:6R8Y|rcsb pdb:6R8Z|rcsb pdb:6R90|rcsb pdb:6R91|rcsb pdb:6R92|rcsb pdb:6SJ7|rcsb pdb:6TD3|rcsb pdb:6UD7|rcsb pdb:6UE5|rcsb pdb:6UML|rcsb pdb:6XK9|rcsb pdb:7LPS|reactome:R-HSA-110314|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-8951664|go:"GO:0031464"(Cul4A-RING E3 ubiquitin ligase complex)|go:"GO:0031465"(Cul4B-RING E3 ubiquitin ligase complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0048511"(rhythmic process)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070914"(UV-damage excision repair)|go:"GO:0071987"(WD40-repeat domain binding)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|go:"GO:0097602"(cullin family protein binding)|go:"GO:1901990"(regulation of mitotic cell cycle phase transition)|go:"GO:1902188"(obsolete positive regulation of viral release from host cell)|interpro:IPR004871(Cleavage and polyadenylation specificity factor, A subunit, C-terminal)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR018846|interpro:IPR031297|interpro:IPR036322|mint:Q16531|rcsb pdb:2B5L|rcsb pdb:2B5M|rcsb pdb:2B5N|rcsb pdb:2HYE|rcsb pdb:3E0C|rcsb pdb:3EI1|rcsb pdb:3EI2|rcsb pdb:3EI3|rcsb pdb:3EI4|rcsb pdb:3I7H|rcsb pdb:3I7K|rcsb pdb:3I7L|rcsb pdb:3I7N|rcsb pdb:3I7O|rcsb pdb:3I7P|dip:DIP-430N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:qgMjZqvlsbGIGn2qM/pnLTtGyGM9606	rigid:CelGHryexKPZHgGga7cBUIKcndw	false	sufficient binding region:791-1222	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q13561	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-715074|uniprotkb:Q86YN2|uniprotkb:Q9BW17|uniprotkb:B2RBK5|ensembl:ENSP00000447824	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:dctn2_human(display_long)|uniprotkb:Dynactin complex 50 kDa subunit(gene name synonym)|uniprotkb:50 kDa dynein-associated polypeptide(gene name synonym)|uniprotkb:p50 dynamitin(gene name synonym)|uniprotkb:DCTN2(gene name)|psi-mi:DCTN2(display_short)|uniprotkb:DCTN50(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514010|imex:IM-28561-169	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_006391.1|refseq:NP_001248341.1|refseq:NP_001248342.1|dip:DIP-37545N|reactome:R-HSA-2565942|reactome:R-HSA-3371497|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-6807878|reactome:R-HSA-6811436|reactome:R-HSA-8854518|ensembl:ENSG00000175203(gene)|ensembl:ENST00000548249(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005869"(dynactin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030286"(dynein complex)|go:"GO:0030426"(growth cone)|go:"GO:0030507"(spectrin binding)|go:"GO:0031982"(vesicle)|go:"GO:0032402"(melanosome transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071539"(protein localization to centrosome)|interpro:IPR028133|mint:Q13561|reactome:R-HSA-2132295	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:JrL5jUtArek+zqmCkPKomnjuSf09606	rigid:E9pprqZrxXE5ivT/lhQYFLJ8Xn8	false	sufficient binding region:791-1222	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q9UJU6	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-751783|uniprotkb:P84070|uniprotkb:Q6IAI8|uniprotkb:Q96F30|uniprotkb:Q96K74|uniprotkb:Q9HBN8|uniprotkb:Q9NR72|uniprotkb:A4D2I9|uniprotkb:B4DEM2|uniprotkb:C9J7P1|uniprotkb:B4DDP6|intact:EBI-28973053|ensembl:ENSP00000411701	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:dbnl_human(display_long)|uniprotkb:Drebrin-F(gene name synonym)|uniprotkb:SH3 domain-containing protein 7(gene name synonym)|uniprotkb:Cervical SH3P7(gene name synonym)|uniprotkb:HPK1-interacting protein of 55 kDa(gene name synonym)|uniprotkb:Cervical mucin-associated protein(gene name synonym)|uniprotkb:DBNL(gene name)|psi-mi:DBNL(display_short)|uniprotkb:CMAP(gene name synonym)|uniprotkb:SH3P7(gene name synonym)|uniprotkb:PP5423(orf name)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514001|imex:IM-28561-1735	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_001271242.1|refseq:NP_001271244.1|refseq:NP_001014436.1|refseq:NP_001116428.1|refseq:NP_054782.2|ensembl:ENST00000440166|ensembl:ENSP00000415173|ensembl:ENSP00000411701|ensembl:ENST00000456905|ensembl:ENSP00000416421|ensembl:ENST00000468694|ensembl:ENSP00000417653|ensembl:ENST00000490734|ensembl:ENSP00000417749|ensembl:ENST00000494774|ensembl:ENSP00000419992|ensembl:ENSG00000136279(gene)|ensembl:ENST00000448521(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001726"(ruffle)|go:"GO:0002102"(podosome)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003779"(actin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0007416"(synapse assembly)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030425"(dendrite)|go:"GO:0030427"(site of polarized growth)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043204"(perikaryon)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051015"(actin filament binding)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071800"(podosome assembly)|go:"GO:0097178"(ruffle assembly)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR001452(Src homology-3)|interpro:IPR002108(Actin-binding, cofilin/tropomyosin type)|interpro:IPR029006|interpro:IPR029923|interpro:IPR035717|interpro:IPR036028|mint:Q9UJU6|rcsb pdb:1X67|reactome:R-HSA-264870|reactome:R-HSA-6794361|reactome:R-HSA-6798695	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:OOa7vGOHVCiCKA9Wt0YUYGR5cu09606	rigid:gBjo0xNkbLRNa6/wWrjBEGKfHgs	false	sufficient binding region:1219-1731	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O60759	uniprotkb:Q9BYB0	intact:EBI-997814|intact:EBI-2803304|uniprotkb:Q15630|uniprotkb:Q8NE32|ensembl:ENSP00000264192|uniprotkb:B4DWH9	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	psi-mi:cytip_human(display_long)|uniprotkb:Cytohesin-binding protein HE(gene name synonym)|uniprotkb:Cytohesin binder and regulator(gene name synonym)|uniprotkb:CYTIP(gene name)|psi-mi:CYTIP(display_short)|uniprotkb:PSCDBP(gene name synonym)|uniprotkb:Cytohesin-associated scaffolding protein(gene name synonym)|uniprotkb:Pleckstrin homology Sec7 and coiled-coil domains-binding protein(gene name synonym)	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513992|imex:IM-28561-819	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004279.3|ensembl:ENSG00000115165(gene)|ensembl:ENST00000264192(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0030155"(regulation of cell adhesion)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|mint:O60759|rcsb pdb:2Z17|refseq:XP_016860875.1	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:2gBEQjAfTYfUd3I3QExqEP3zDtQ9606	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rigid:A9Y3Fnq5Na00L5ff7BgU4vJlDPA	false	-	sufficient binding region:374-740	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q16850	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-2680495|intact:EBI-21358836|uniprotkb:A0A0C4DFL7|uniprotkb:O00770|uniprotkb:Q99868|uniprotkb:Q8N1A8|uniprotkb:O00772|uniprotkb:Q16784|uniprotkb:B2RAI4|uniprotkb:B4DJ55|uniprotkb:A4D1F8	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:cp51a_human(display_long)|uniprotkb:CYP51(gene name synonym)|uniprotkb:CYPLI(gene name synonym)|uniprotkb:Cytochrome P450 51A1(gene name synonym)|uniprotkb:Cytochrome P450-14DM(gene name synonym)|uniprotkb:Cytochrome P450LI(gene name synonym)|uniprotkb:Sterol 14-alpha demethylase(gene name synonym)|uniprotkb:CYP51A1(gene name)|psi-mi:CYP51A1(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513983|imex:IM-28561-167	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	mint:Q16850|refseq:NP_000777.1|refseq:NP_001139624.1|interpro:IPR001128(Cytochrome P450)|interpro:IPR017972|interpro:IPR002403(Cytochrome P450, E-class, group IV)|go:"GO:0008398"(sterol 14-demethylase activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016125"(sterol metabolic process)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0020037"(heme binding)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|rcsb pdb:3JUS|rcsb pdb:3JUV|rcsb pdb:3LD6|rcsb pdb:4UHI|rcsb pdb:4UHL|rcsb pdb:6Q2T|rcsb pdb:6UEZ|reactome:R-HSA-191273|reactome:R-HSA-211976|reactome:R-HSA-2426168|reactome:R-HSA-9619665|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0004497"(monooxygenase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006694"(steroid biosynthetic process)|interpro:IPR036396	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2021/11/30	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:yrFu9QoUi7oRnhwLxzbC3e/jhUE9606	rigid:l7sbPeeANn+pfH5gmkxR8kY9p98	false	sufficient binding region:1219-1731	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q14247	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-351886|intact:EBI-3959948|ensembl:ENSP00000301843|ensembl:ENSP00000500756|uniprotkb:Q8N707|uniprotkb:Q96H99	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:src8_human(display_long)|uniprotkb:CTTN(gene name)|psi-mi:CTTN(display_short)|uniprotkb:EMS1(gene name synonym)|uniprotkb:Amplaxin(gene name synonym)|uniprotkb:Oncogene EMS1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513974|imex:IM-28561-1287	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_005222.2|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0030027"(lamellipodium)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030427"(site of polarized growth)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045296"(cadherin binding)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0051015"(actin filament binding)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0097581"(lamellipodium organization)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1990023"(mitotic spindle midzone)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR003134(Hs1/Cortactin)|interpro:IPR015503(Cortactin)|interpro:IPR035716|interpro:IPR036028|mint:Q14247|rcsb pdb:1X69|rcsb pdb:2D1X|reactome:R-HSA-5627123|reactome:R-HSA-8856828|ensembl:ENSG00000085733(gene)|ensembl:ENSG00000288401(gene)|ensembl:ENST00000301843(transcript)|ensembl:ENST00000671805(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0002102"(podosome)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|refseq:NP_001171669.1|refseq:NP_612632.1|dip:DIP-33190N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:uzhAnL5Fu9Mgg9/LWeNiaYIwNVU9606	rigid:CZvMMJ/5LshsxEY9LuweYAvfZHQ	false	sufficient binding region:1219-1731	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:P48730	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-751621|uniprotkb:Q96KZ6|uniprotkb:Q9BTN5|uniprotkb:A2I2P2|ensembl:ENSP00000324464	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:kc1d_human(display_long)|uniprotkb:CSNK1D(gene name)|psi-mi:CSNK1D(display_short)|uniprotkb:HCKID(gene name synonym)|uniprotkb:Tau-protein kinase CSNK1D(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513965|imex:IM-28561-385	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_001884.2|refseq:NP_620693.1|dip:DIP-39735N|ensembl:ENSG00000141551(gene)|ensembl:ENST00000314028(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007030"(Golgi organization)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043005"(neuron projection)|go:"GO:0045296"(cadherin binding)|go:"GO:0048208"(COPII vesicle coating)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0051225"(spindle assembly)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1905426"(positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation)|go:"GO:1905515"(non-motile cilium assembly)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000052"(positive regulation of non-canonical Wnt signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P48730|rcsb pdb:3UYS|rcsb pdb:3UYT|rcsb pdb:3UZP|rcsb pdb:4HGT|rcsb pdb:4HNF|rcsb pdb:4KB8|rcsb pdb:4KBA|rcsb pdb:4KBC|rcsb pdb:4KBK|rcsb pdb:4TN6|rcsb pdb:4TW9|rcsb pdb:4TWC|rcsb pdb:5IH4|rcsb pdb:5IH5|rcsb pdb:5IH6|rcsb pdb:5MQV|rcsb pdb:5OKT|rcsb pdb:5W4W|rcsb pdb:6F1W|rcsb pdb:6F26|rcsb pdb:6GZM|rcsb pdb:6HMP|rcsb pdb:6HMR|rcsb pdb:6PXN|rcsb pdb:6PXO|rcsb pdb:6PXP|rcsb pdb:6RCG|rcsb pdb:6RCH|rcsb pdb:6RU6|rcsb pdb:6RU7|rcsb pdb:6RU8|reactome:R-HSA-204005|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-400253|reactome:R-HSA-5620912|reactome:R-HSA-6791226|reactome:R-HSA-8854518	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:Rz5aON17Bfduv29izmgHa/FR1/49606	rigid:7C6lBoyqjIUDkaZYsJULPa58aSk	false	sufficient binding region:791-1222	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q96HD1	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-713009|uniprotkb:Q6I9X5|uniprotkb:Q8NFT4|uniprotkb:Q9Y409|uniprotkb:A8MX90|uniprotkb:B2RAA9|ensembl:ENSP00000373322|ensembl:ENSP00000393643|ensembl:ENSP00000507127|ensembl:ENSP00000508358	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:crel1_human(display_long)|uniprotkb:CRELD1(gene name)|psi-mi:CRELD1(display_short)|uniprotkb:CIRRIN(gene name synonym)|uniprotkb:Cysteine-rich with EGF-like domain protein 1(gene name synonym)|uniprotkb:UNQ188/PRO214(orf name)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513956|imex:IM-28561-165	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_001026887.1|refseq:NP_001070883.1|refseq:NP_056328.2|refseq:XP_016862664.1|ensembl:ENSG00000163703(gene)|ensembl:ENST00000383811(transcript)|ensembl:ENST00000452070(transcript)|ensembl:ENST00000682783(transcript)|ensembl:ENST00000684493(transcript)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003279"(cardiac septum development)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002049(EGF-like, laminin)|interpro:IPR006212(Furin-like repeat)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR018097|interpro:IPR021852|mint:Q96HD1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:YCHTMCBYRLSWAJ4W+2lmt/EjUlQ9606	rigid:WYCpjjCOEHm28phTDEgJBt1GNho	false	sufficient binding region:791-1222	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q5HYK3	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-12577722|ensembl:ENSP00000288532|uniprotkb:B2RDU9|uniprotkb:B3GK62|uniprotkb:B4DEJ4|uniprotkb:Q32Q28|uniprotkb:Q53HH0|uniprotkb:Q96LV1|uniprotkb:Q9BSP8	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:coq5_human(display_long)|uniprotkb:COQ5(gene name)|psi-mi:COQ5(display_short)|uniprotkb:Ubiquinone biosynthesis methyltransferase COQ5(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513947|imex:IM-28561-1279	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	ensembl:ENSG00000110871(gene)|ensembl:ENST00000288532(transcript)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006744"(ubiquinone biosynthetic process)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0031314"(extrinsic component of mitochondrial inner membrane)|go:"GO:0032259"(methylation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043333"(2-octaprenyl-6-methoxy-1,4-benzoquinone methylase activity)|go:"GO:0043430"(2-decaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity)|interpro:IPR004033(UbiE/COQ5 methyltransferase)|interpro:IPR023576|interpro:IPR029063|mint:Q5HYK3|reactome:R-HSA-2142789|refseq:NP_115690.3	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:zyV+GL8MivuqPdn5qkE6zEjYCkc9606	rigid:KrS11aTTjXSlGCJnFD/rMOkwAeA	false	sufficient binding region:374-740	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q7L5N1	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-486838|uniprotkb:O15387|uniprotkb:A4D2A3|ensembl:ENSP00000304102	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:csn6_human(display_long)|uniprotkb:COPS6(gene name)|psi-mi:COPS6(display_short)|uniprotkb:CSN6(gene name synonym)|uniprotkb:HVIP(gene name synonym)|uniprotkb:JAB1-containing signalosome subunit 6(gene name synonym)|uniprotkb:Vpr-interacting protein(gene name synonym)|uniprotkb:MOV34 homolog(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513938|imex:IM-28561-163	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_006824.2|ensembl:ENSG00000168090(gene)|ensembl:ENST00000303904(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070122"(isopeptidase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR033859|interpro:IPR024969|interpro:IPR037518|mint:Q7L5N1|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4QFT|rcsb pdb:4R14|rcsb pdb:4WSN|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664|dip:DIP-32655N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:hyuYyAujJCJtbfS2tJ+UgH7jWP89606	rigid:pzTHzp9yXuwYmRKCHkAE8t+exjI	false	sufficient binding region:791-1222	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:P10909	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-1104674|uniprotkb:B3KSE6|uniprotkb:P11380|uniprotkb:P11381|uniprotkb:Q5HYC1|uniprotkb:Q7Z5B9|uniprotkb:B2R9Q1|uniprotkb:Q2TU75|ensembl:ENSP00000315130|ensembl:ENSP00000385419|ensembl:ENSP00000429620	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:clus_human(display_long)|uniprotkb:CLU(gene name)|psi-mi:CLU(display_short)|uniprotkb:APOJ(gene name synonym)|uniprotkb:CLI(gene name synonym)|uniprotkb:KUB1(gene name synonym)|uniprotkb:Complement-associated protein SP-40,40(gene name synonym)|uniprotkb:Complement cytolysis inhibitor(gene name synonym)|uniprotkb:NA1/NA2(gene name synonym)|uniprotkb:Apolipoprotein J(gene name synonym)|uniprotkb:Testosterone-repressed prostate message 2(gene name synonym)|uniprotkb:Ku70-binding protein 1(gene name synonym)|uniprotkb:Aging-associated gene 4 protein(gene name synonym)|uniprotkb:AAG4(orf name)|uniprotkb:Sulfated glycoprotein 2(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513929|imex:IM-28561-603	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	go:"GO:0006629"(lipid metabolic process)|go:"GO:0006956"(complement activation)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0009615"(response to virus)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0017038"(protein import)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032286"(central nervous system myelin maintenance)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0005829"(cytosol)|ensembl:ENSG00000120885(gene)|ensembl:ENST00000316403(transcript)|ensembl:ENST00000405140(transcript)|ensembl:ENST00000523500(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0002434"(immune complex clearance)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0034366"(spherical high-density lipoprotein particle)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042583"(chromaffin granule)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043691"(reverse cholesterol transport)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045202"(synapse)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048156"(tau protein binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0051788"(response to misfolded protein)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:0061740"(protein targeting to lysosome involved in chaperone-mediated autophagy)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0097418"(neurofibrillary tangle)|go:"GO:0097440"(apical dendrite)|go:"GO:0099020"(perinuclear endoplasmic reticulum lumen)|go:"GO:0140597"(protein carrier chaperone)|go:"GO:1900221"(regulation of amyloid-beta clearance)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902847"(regulation of neuronal signal transduction)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1902998"(positive regulation of neurofibrillary tangle assembly)|go:"GO:1903573"(negative regulation of response to endoplasmic reticulum stress)|go:"GO:1905892"(negative regulation of cellular response to thapsigargin)|go:"GO:1905895"(negative regulation of cellular response to tunicamycin)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:1905908"(positive regulation of amyloid fibril formation)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000753(Clusterin-like)|interpro:IPR016014(Clusterin, N-terminal)|interpro:IPR016015(Clusterin, C-terminal)|interpro:IPR016016(Clusterin)|interpro:IPR033986|mint:P10909|reactome:R-HSA-114608|reactome:R-HSA-166665|reactome:R-HSA-6803157|go:"GO:0060548"(negative regulation of cell death)|reactome:R-HSA-977606|refseq:NP_001822.3|dip:DIP-37546N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:qlCJp4zYTklC3YZNQvbLmZBiz4U9606	rigid:4CpDT4ZzB/Ht1P92GWsfQFnj7IY	false	sufficient binding region:374-740	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:P09496	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-1171169|uniprotkb:Q2XPN5|uniprotkb:Q53XZ1|uniprotkb:A8K4W3|uniprotkb:B4DIN1|uniprotkb:F5H6N3|ensembl:ENSP00000242285|ensembl:ENSP00000401019	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:clca_human(display_long)|uniprotkb:CLTA(gene name)|psi-mi:CLTA(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513920|imex:IM-28561-1057	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_001070145.1|refseq:NP_001824.1|refseq:NP_009027.1|refseq:NP_001171689.1|refseq:NP_001171691.1|ensembl:ENSG00000122705(gene)|ensembl:ENST00000242285(transcript)|ensembl:ENST00000433436(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007049"(cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0030118"(clathrin coat)|go:"GO:0030125"(clathrin vesicle coat)|go:"GO:0030130"(clathrin coat of trans-Golgi network vesicle)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0042277"(peptide binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0051020"(GTPase binding)|go:"GO:0051301"(cell division)|go:"GO:0071439"(clathrin complex)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0098835"(presynaptic endocytic zone membrane)|go:"GO:0099631"(postsynaptic endocytic zone cytoplasmic component)|interpro:IPR000996(Clathrin light chain)|mint:P09496|rcsb pdb:6E5N|reactome:R-HSA-168275|reactome:R-HSA-177504|reactome:R-HSA-190873|reactome:R-HSA-196025|reactome:R-HSA-2132295|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-437239|reactome:R-HSA-5099900|reactome:R-HSA-5140745|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866427|reactome:R-HSA-8964038|reactome:R-HSA-3928665	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:RCF3QpQKI1yZFOTAyzhvRkR9ek49606	rigid:Wa98HxkxmbgpgPrQ2rhuVkZK3+c	false	sufficient binding region:791-1222	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q9P209	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-739498|uniprotkb:Q9BV03|uniprotkb:Q9BWM3|uniprotkb:Q9NVR4|uniprotkb:B4DR26|ensembl:ENSP00000264935	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:cep72_human(display_long)|uniprotkb:CEP72(gene name)|psi-mi:CEP72(display_short)|uniprotkb:KIAA1519(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513911|imex:IM-28561-1277	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_060610.2|ensembl:ENSG00000112877(gene)|ensembl:ENST00000264935(transcript)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007051"(spindle organization)|go:"GO:0007099"(centriole replication)|go:"GO:0033566"(gamma-tubulin complex localization)|go:"GO:0034451"(centriolar satellite)|go:"GO:1904779"(regulation of protein localization to centrosome)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR003603(U2A'/phosphoprotein 32 family A, C-terminal)|interpro:IPR032675|interpro:IPR040146|mint:Q9P209|reactome:R-HSA-2565942|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-8854518|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|refseq:XP_011512365.1|dip:DIP-54272N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:c00WdgE2iudiQUz3kXNZL5d0nuQ9606	rigid:uMaD2fcsj2JgQZLXl7YhbnO3JNk	false	sufficient binding region:791-1222	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q9HC77	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-946194|uniprotkb:Q2KHM6|uniprotkb:Q5T6R5|uniprotkb:Q96KS5|uniprotkb:Q9C067|uniprotkb:Q5JPD5|ensembl:ENSP00000371308	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:cenpj_human(display_long)|uniprotkb:CENPJ(gene name)|psi-mi:CENPJ(display_short)|uniprotkb:CPAP(gene name synonym)|uniprotkb:LAP(gene name synonym)|uniprotkb:LIP1(gene name synonym)|uniprotkb:Centrosomal P4.1-associated protein(gene name synonym)|uniprotkb:LAG-3-associated protein(gene name synonym)|uniprotkb:LYST-interacting protein 1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513902|imex:IM-28561-817	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_060921.3|dip:DIP-49904N|ensembl:ENSG00000151849(gene)|ensembl:ENST00000381884(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007099"(centriole replication)|go:"GO:0008275"(gamma-tubulin small complex)|go:"GO:0015631"(tubulin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030954"(astral microtubule nucleation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046599"(regulation of centriole replication)|go:"GO:0046785"(microtubule polymerization)|go:"GO:0051301"(cell division)|go:"GO:0060271"(cilium assembly)|go:"GO:0061511"(centriole elongation)|go:"GO:1903724"(positive regulation of centriole elongation)|go:"GO:1904951"(positive regulation of establishment of protein localization)|interpro:IPR009852(T-complex 10/CenJ, C-terminal)|interpro:IPR026581|interpro:IPR033068|mint:Q9HC77|rcsb pdb:5EIB|rcsb pdb:5ITZ|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-6804115|reactome:R-HSA-8854518	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:y2LeLFP5R4hOjDjIkXsY1bZE3IA9606	rigid:8U+1tKlzPhDyOiq3hR8AGe2XzAE	false	sufficient binding region:1219-1731	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:P49368	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-356673|uniprotkb:Q5SZY1|uniprotkb:Q9BR64|uniprotkb:A6NE14|ensembl:ENSP00000295688	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:tcpg_human(display_long)|uniprotkb:CCT3(gene name)|psi-mi:CCT3(display_short)|uniprotkb:CCTG(gene name synonym)|uniprotkb:TRIC5(gene name synonym)|uniprotkb:CCT-gamma(gene name synonym)|uniprotkb:hTRiC5(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513893|imex:IM-28561-1733	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_001008800.1|refseq:NP_005989.3|ensembl:ENSG00000163468(gene)|ensembl:ENST00000295688(transcript)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0046931"(pore complex assembly)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1901998"(toxin transport)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012719(T-complex protein 1, gamma subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P49368|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-5620922|reactome:R-HSA-6814122|dip:DIP-32970N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:2Vh45aNIeqiAp1NHbIabV2kEYUU9606	rigid:zn7uFK+Lwp4/Xx9t0k/BbyB0F7A	false	sufficient binding region:374-740	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q13554	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-1058722|ensembl:ENSP00000379098|uniprotkb:A4D2K1|uniprotkb:A4D2K2|uniprotkb:Q9UGH9|uniprotkb:Q9UNX0|uniprotkb:Q9UNX7|uniprotkb:O95437|uniprotkb:O95438|uniprotkb:Q9UP00|uniprotkb:Q9Y5N4|uniprotkb:Q9Y6F4|uniprotkb:A4D2K0|uniprotkb:O95599|uniprotkb:Q9UGH7|uniprotkb:Q9UGH8|uniprotkb:A4D2K4|uniprotkb:A4D2K6|uniprotkb:A4D2K3|intact:EBI-1383493|uniprotkb:A4D2K5	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:kcc2b_human(display_long)|uniprotkb:CAMK2B(gene name)|psi-mi:CAMK2B(display_short)|uniprotkb:CAM2(gene name synonym)|uniprotkb:CAMKB(gene name synonym)|uniprotkb:CAMK2(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513884|imex:IM-28561-1275	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	ensembl:ENSG00000058404(gene)|ensembl:ENST00000395749(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005954"(calcium- and calmodulin-dependent protein kinase complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014733"(regulation of skeletal muscle adaptation)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|refseq:NP_001211.3|refseq:NP_742075.1|refseq:NP_742076.1|refseq:NP_742077.1|refseq:NP_742078.1|refseq:NP_742079.1|refseq:NP_742080.1|refseq:NP_742081.1|mint:Q13554|rcsb pdb:3BHH|reactome:R-HSA-111932|reactome:R-HSA-3371571|reactome:R-HSA-399719|reactome:R-HSA-438066|reactome:R-HSA-442729|reactome:R-HSA-442982|reactome:R-HSA-5576892|reactome:R-HSA-5578775|reactome:R-HSA-5673000|reactome:R-HSA-5673001|reactome:R-HSA-6802946|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-877300|reactome:R-HSA-9022692|reactome:R-HSA-936837|reactome:R-HSA-9609736|interpro:IPR032710|reactome:R-HSA-9617324|reactome:R-HSA-9620244|reactome:R-HSA-9649948|reactome:R-HSA-9656223|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0051823"(regulation of synapse structural plasticity)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0090129"(positive regulation of synapse maturation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2001222"(regulation of neuron migration)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|refseq:NP_001280099.1|dip:DIP-39770N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:3RDzSxLdoGtWTECo9At60gEZfZY9606	rigid:EJyImQu9JCbrtxSzf64fmf+Z4zM	false	sufficient binding region:1219-1731,791-1222	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q9P1Z2	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-749920|uniprotkb:B3KVA8|uniprotkb:Q6FI59|uniprotkb:Q71RC3|uniprotkb:Q86WF8|uniprotkb:Q96JU3|uniprotkb:Q9H090|intact:EBI-2558801|ensembl:ENSP00000449960	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:caco1_human(display_long)|uniprotkb:CALCOCO1(gene name)|psi-mi:CALCOCO1(display_short)|uniprotkb:KIAA1536(gene name synonym)|uniprotkb:Calphoglin(gene name synonym)|uniprotkb:Sarcoma antigen NY-SAR-3(gene name synonym)|uniprotkb:Coiled-coil coactivator protein(gene name synonym)|uniprotkb:PP13275(orf name)|uniprotkb:UNQ2436/PRO4996(orf name)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513875|imex:IM-28561-1517	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_001137154.1|refseq:NP_065949.1|refseq:XP_016875196.1|dip:DIP-47322N|ensembl:ENSG00000012822(gene)|ensembl:ENST00000550804(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0007165"(signal transduction)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030518"(intracellular steroid hormone receptor signaling pathway)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0070016"(armadillo repeat domain binding)|interpro:IPR012852(Coiled-coil transcriptional coactivator-like)|interpro:IPR041611|interpro:IPR041641|mint:Q9P1Z2	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:4M9Qyq+7GZ1w2UAN6k0ntGQNTvw9606	rigid:uRZoCB6JMUduNpjsCulNdTSSL0g	false	sufficient binding region:374-740	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q9NS85	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-21798903|uniprotkb:B2R7J0|uniprotkb:B4DGL6|intact:EBI-28972912|ensembl:ENSP00000285273|ensembl:ENSP00000390666|ensembl:ENSP00000405388	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:cah10_human(display_long)|uniprotkb:Carbonic anhydrase-related protein X(gene name synonym)|uniprotkb:Cerebral protein 15(gene name synonym)|uniprotkb:UNQ533/PRO1076(orf name)|uniprotkb:hucep-15(orf name)|uniprotkb:CA10(gene name)|psi-mi:CA10(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513866|imex:IM-28561-161	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	ensembl:ENSP00000285273|ensembl:ENSP00000390666|ensembl:ENSP00000405388|ensembl:ENST00000570565|ensembl:ENSP00000459619|refseq:NP_001076002.1|refseq:NP_001076003.1|refseq:NP_064563.1|ensembl:ENSG00000154975(gene)|ensembl:ENST00000285273(transcript)|ensembl:ENST00000442502(transcript)|ensembl:ENST00000451037(transcript)|go:"GO:0004089"(carbonate dehydratase activity)|go:"GO:0006730"(one-carbon metabolic process)|go:"GO:0007420"(brain development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016836"(hydro-lyase activity)|interpro:IPR001148(Carbonic anhydrase, eukaryotic)|interpro:IPR018423|interpro:IPR023561|interpro:IPR036398|interpro:IPR041878|mint:Q9NS85	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:cz53+aW3y6Pg+D7UIp/FJ1J9WjE9606	rigid:vYdGNqpAyM4pLyqiqd1Qy0xGzNE	false	sufficient binding region:1219-1731	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q5JTD7	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-12003882|ensembl:ENSP00000361518	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:lrc73_human(display_long)|uniprotkb:LRRC73(gene name)|psi-mi:LRRC73(display_short)|uniprotkb:C6orf154(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513857|imex:IM-28561-815	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	ensembl:ENSG00000204052(gene)|ensembl:ENST00000372441(transcript)|interpro:IPR032675|interpro:IPR039984|mint:Q5JTD7|refseq:NP_001012992.1|refseq:NP_001258811.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:0Vk9403qLSuzVE1dxCB/jdJAOck9606	rigid:JF40iwLUih0v43Xbx1R7P9qyhWo	false	sufficient binding region:374-740	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q07021	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-347528|uniprotkb:Q2HXR8|uniprotkb:Q9NNY8|intact:EBI-15990352|ensembl:ENSP00000225698	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:c1qbp_human(display_long)|uniprotkb:C1QBP(gene name)|psi-mi:C1QBP(display_short)|uniprotkb:GC1QBP(gene name synonym)|uniprotkb:HABP1(gene name synonym)|uniprotkb:SF2P32(gene name synonym)|uniprotkb:Glycoprotein gC1qBP(gene name synonym)|uniprotkb:Hyaluronan-binding protein 1(gene name synonym)|uniprotkb:Mitochondrial matrix protein p32(gene name synonym)|uniprotkb:p33(gene name synonym)|uniprotkb:ASF/SF2-associated protein p32(gene name synonym)|uniprotkb:gC1q-R protein(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513848|imex:IM-28561-1273	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_001203.1|dip:DIP-31164N|ensembl:ENSG00000108561(gene)|ensembl:ENST00000225698(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005540"(hyaluronic acid binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006397"(mRNA processing)|go:"GO:0006915"(apoptotic process)|go:"GO:0006955"(immune response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0008494"(translation activator activity)|go:"GO:0009986"(cell surface)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0030449"(regulation of complement activation)|go:"GO:0030984"(kininogen binding)|go:"GO:0031690"(adrenergic receptor binding)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0039534"(negative regulation of MDA-5 signaling pathway)|go:"GO:0039536"(negative regulation of RIG-I signaling pathway)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0042256"(mature ribosome assembly)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050687"(negative regulation of defense response to virus)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070131"(positive regulation of mitochondrial translation)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0097177"(mitochondrial ribosome binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:2000510"(positive regulation of dendritic cell chemotaxis)|interpro:IPR003428(Mitochondrial glycoprotein)|interpro:IPR036561|mint:Q07021|rcsb pdb:1P32|rcsb pdb:3RPX|rcsb pdb:6SZW|reactome:R-HSA-111471|go:"GO:0005886"(plasma membrane)|reactome:R-HSA-8980692|reactome:R-HSA-9013106|reactome:R-HSA-9645722|reactome:R-HSA-140837	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:NfZ31HjbYZxd8UQKRXczhpc306E9606	rigid:0upy0F7jmU9N0yETRhVldd0iQqs	false	sufficient binding region:791-1222	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q9BPX5	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-711189|ensembl:ENSP00000259477|ensembl:ENSP00000345361|uniprotkb:Q7Z523	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:arp5l_human(display_long)|uniprotkb:Arp2/3 complex 16 kDa subunit 2(gene name synonym)|uniprotkb:ARPC5L(gene name)|psi-mi:ARPC5L(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26513821|imex:IM-28561-1271	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_112240.1|ensembl:ENSG00000136950(gene)|ensembl:ENST00000259477(transcript)|ensembl:ENST00000353214(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005885"(Arp2/3 protein complex)|go:"GO:0005925"(focal adhesion)|go:"GO:0016477"(cell migration)|go:"GO:0034314"(Arp2/3 complex-mediated actin nucleation)|go:"GO:0051015"(actin filament binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR006789("ARP2/3 complex 16 kDa subunit (p16-Arc)")|interpro:IPR030075|interpro:IPR036743|mint:Q9BPX5|rcsb pdb:6YW6|dip:DIP-50399N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:JVproBu8rIrnlk39yXPC+ZrvoOk9606	rigid:/jrEi5WPzoPspLGFUwRfKTTEsLo	false	sufficient binding region:1219-1731	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q96N66	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-6116499|ensembl:ENSP00000245615|ensembl:ENSP00000478041|ensembl:ENSP00000478088|ensembl:ENSP00000478965|ensembl:ENSP00000481455|ensembl:ENSP00000482252|ensembl:ENSP00000482625|ensembl:ENSP00000484199|ensembl:ENSP00000484933|ensembl:ENSP00000484954|uniprotkb:A9C4B6|uniprotkb:B0V3I5|uniprotkb:B4DQ87|uniprotkb:Q05DF0|uniprotkb:Q7L5N2|uniprotkb:Q99908|uniprotkb:Q9BPV2|uniprotkb:Q9BRE9	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:mboa7_human(display_long)|uniprotkb:MBOAT7(gene name)|psi-mi:MBOAT7(display_short)|uniprotkb:BB1(gene name synonym)|uniprotkb:LENG4(gene name synonym)|uniprotkb:OACT7(gene name synonym)|uniprotkb:1-acylglycerophosphatidylinositol O-acyltransferase(gene name synonym)|uniprotkb:Bladder and breast carcinoma-overexpressed gene 1 protein(gene name synonym)|uniprotkb:Leukocyte receptor cluster member 4(gene name synonym)|uniprotkb:Lysophosphatidylinositol acyltransferase(gene name synonym)|uniprotkb:Membrane-bound O-acyltransferase domain-containing protein 7(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514458|imex:IM-28561-195	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:XP_011525601.1|refseq:XP_011525602.1|ensembl:ENSG00000125505(gene)|ensembl:ENSG00000273592(gene)|ensembl:ENSG00000274194(gene)|ensembl:ENSG00000275118(gene)|ensembl:ENSG00000276935(gene)|ensembl:ENSG00000277025(gene)|ensembl:ENSG00000277733(gene)|ensembl:ENSG00000277923(gene)|ensembl:ENSG00000278322(gene)|ensembl:ENSG00000278519(gene)|refseq:NP_001139528.1|refseq:NP_001139554.1|refseq:NP_001139555.1|refseq:NP_077274.3|ensembl:ENST00000245615(transcript)|ensembl:ENST00000613506(transcript)|ensembl:ENST00000613746(transcript)|ensembl:ENST00000615453(transcript)|ensembl:ENST00000617012(transcript)|ensembl:ENST00000618378(transcript)|ensembl:ENST00000619842(transcript)|ensembl:ENST00000619855(transcript)|ensembl:ENST00000621612(transcript)|ensembl:ENST00000621875(transcript)|go:"GO:0003841"(1-acylglycerol-3-phosphate O-acyltransferase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0008374"(O-acyltransferase activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016746"(acyltransferase activity)|go:"GO:0021591"(ventricular system development)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0030258"(lipid modification)|go:"GO:0036149"(phosphatidylinositol acyl-chain remodeling)|go:"GO:0036151"(phosphatidylcholine acyl-chain remodeling)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0047144"(2-acylglycerol-3-phosphate O-acyltransferase activity)|go:"GO:0071617"(lysophospholipid acyltransferase activity)|go:"GO:0090207"(regulation of triglyceride metabolic process)|interpro:IPR004299(Membrane bound O-acyl transferase, MBOAT)|mint:Q96N66|reactome:R-HSA-1482922	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:NdxbWV63CtA/flzPPhYadlBQksU9606	rigid:U6fmbEO9kGGiPp6zgbtQGCxb84E	false	sufficient binding region:791-1222	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q9NS73	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-741953|uniprotkb:Q86TZ2|uniprotkb:Q96AS5|uniprotkb:Q9BS93|uniprotkb:Q9NZE1|ensembl:ENSP00000399718	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:mbip1_human(display_long)|uniprotkb:MAPK upstream kinase-binding inhibitory protein(gene name synonym)|uniprotkb:MBIP(gene name)|psi-mi:MBIP(display_short)|uniprotkb:BM-015(orf name)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514449|imex:IM-28561-1077	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_001138363.1|refseq:NP_057670.2|ensembl:ENSG00000151332(gene)|ensembl:ENST00000416007(transcript)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005671"(obsolete Ada2/Gcn5/Ada3 transcription activator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0042802"(identical protein binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0046330"(positive regulation of JNK cascade)|interpro:IPR026062|mint:Q9NS73|reactome:R-HSA-3214847|go:"GO:0005654"(nucleoplasm)|refseq:NP_001295039.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:PjaEuab6wwOyGImpNYFZfQ+TUvU9606	rigid:44uiQVzirGm/tSi4nm7I7M/na/A	false	sufficient binding region:791-1222	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q9BRK4	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-741037|ensembl:ENSP00000359240|ensembl:ENSP00000359243|uniprotkb:Q8N3I0|uniprotkb:Q96J79|uniprotkb:Q96JL2|uniprotkb:B1AL14|uniprotkb:D3DR72	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:lzts2_human(display_long)|uniprotkb:Protein LAPSER1(gene name synonym)|uniprotkb:LZTS2(gene name)|psi-mi:LZTS2(display_short)|uniprotkb:KIAA1813(gene name synonym)|uniprotkb:LAPSER1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514440|imex:IM-28561-633	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_115805.1|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030496"(midbody)|go:"GO:0031982"(vesicle)|go:"GO:0051013"(microtubule severing)|go:"GO:0051168"(nuclear export)|go:"GO:0051255"(spindle midzone assembly)|go:"GO:0060682"(primary ureteric bud growth)|go:"GO:0072197"(ureter morphogenesis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|interpro:IPR028597|mint:Q9BRK4|ensembl:ENSG00000107816(gene)|ensembl:ENST00000370220(transcript)|ensembl:ENST00000370223(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0008285"(negative regulation of cell population proliferation)|refseq:XP_016872269.1|refseq:NP_001305028.1|refseq:NP_001305029.1|refseq:NP_001305030.1|refseq:XP_005270279.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:OaMJmnmfm6JniKUJeyg7fS6zRcw9606	rigid:kiIl60E1SzvwpiVnKTcOb8wop6I	false	sufficient binding region:374-740	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q8N2S1	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-947718|uniprotkb:O75412|uniprotkb:O75413|uniprotkb:O00508|ensembl:ENSP00000311905	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:ltbp4_human(display_long)|uniprotkb:LTBP4(gene name)|psi-mi:LTBP4(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514431|imex:IM-28561-1755	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_001036009.1|refseq:NP_001036010.1|refseq:NP_003564.2|ensembl:ENSG00000090006(gene)|ensembl:ENST00000308370(transcript)|go:"GO:0001527"(microfibril)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006457"(protein folding)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007275"(multicellular organism development)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0030252"(growth hormone secretion)|go:"GO:0031012"(extracellular matrix)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0048251"(elastic fiber assembly)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR017878|interpro:IPR018097|interpro:IPR036773|mint:Q8N2S1|reactome:R-HSA-2129379	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:mBWo9asZp3rjkytgvTD+7OE5K5I9606	rigid:6TIkX1ZJFIstm1YNH/kPtBsNaC0	false	sufficient binding region:1219-1731,791-1222	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q9NS15	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-3927098|uniprotkb:Q9H7K2|uniprotkb:Q96HB9|uniprotkb:Q9UFN4|uniprotkb:O15107|ensembl:ENSP00000301873	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:ltbp3_human(display_long)|uniprotkb:LTBP3(gene name)|psi-mi:LTBP3(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514422|imex:IM-28561-619	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_001123616.1|refseq:NP_001157738.1|refseq:NP_066548.2|go:"GO:0036363"(transforming growth factor beta activation)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0046849"(bone remodeling)|go:"GO:0048251"(elastic fiber assembly)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0060430"(lung saccule development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:1902462"(positive regulation of mesenchymal stem cell proliferation)|go:"GO:2000741"(positive regulation of mesenchymal stem cell differentiation)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR017878|interpro:IPR018097|interpro:IPR026823|interpro:IPR036773|mint:Q9NS15|reactome:R-HSA-2129379|ensembl:ENSG00000168056(gene)|ensembl:ENST00000301873(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:wTlw1eFDbHiWYm9/2sgGxqK1uI49606	rigid:FR7Yz+uOUrvJJ+/A0mI+1qGY/yU	false	sufficient binding region:1219-1731,791-1222	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:O94910	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-3389315|uniprotkb:Q9BU07|uniprotkb:Q9HAR3|uniprotkb:Q96IE7|ensembl:ENSP00000340688|ensembl:ENSP00000500240	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:agrl1_human(display_long)|uniprotkb:ADGRL1(gene name)|psi-mi:ADGRL1(display_short)|uniprotkb:Calcium-independent alpha-latrotoxin receptor 1(gene name synonym)|uniprotkb:KIAA0821(gene name synonym)|uniprotkb:LEC2(gene name synonym)|uniprotkb:LPHN1(gene name synonym)|uniprotkb:Latrophilin-1(gene name synonym)|uniprotkb:Lectomedin-2(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514413|imex:IM-28561-1535	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_001008701.1|refseq:NP_055736.2|ensembl:ENSG00000072071(gene)|ensembl:ENSG00000288324(gene)|ensembl:ENST00000340736(transcript)|ensembl:ENST00000672190(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016524"(latrotoxin receptor activity)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0090129"(positive regulation of synapse maturation)|interpro:IPR000203(GPS)|interpro:IPR000832(GPCR, family 2, secretin-like)|interpro:IPR000922(D-galactoside/L-rhamnose binding SUEL lectin)|interpro:IPR001879(GPCR, family 2, extracellular region)|interpro:IPR003112(Olfactomedin-like)|interpro:IPR003334(GPCR, family 2, latrophilin, C-terminal)|interpro:IPR003924(GPCR, family 2, latrophilin)|interpro:IPR017981|interpro:IPR017983|interpro:IPR031234|interpro:IPR032471|interpro:IPR036445|interpro:IPR043159|mint:O94910	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:kHETaGfz/t0XytDX2HWU7/xty589606	rigid:yAFRXbpBrHNvrtXzy3K40HyMm+4	false	sufficient binding region:374-740	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q96FE5	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-719955|uniprotkb:Q6VVG2|uniprotkb:Q6NUK3|uniprotkb:Q6UXM3|uniprotkb:Q6VVG0|uniprotkb:Q6VVG1|uniprotkb:Q8N3K5|uniprotkb:Q96K52|uniprotkb:D3DW80|ensembl:ENSP00000347451	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:ligo1_human(display_long)|uniprotkb:LERN1(gene name synonym)|uniprotkb:Leucine-rich repeat neuronal protein 6A(gene name synonym)|uniprotkb:Leucine-rich repeat neuronal protein 1(gene name synonym)|uniprotkb:UNQ201/PRO227(orf name)|uniprotkb:LINGO1(gene name)|psi-mi:LINGO1(display_short)|uniprotkb:LRRN6A(gene name synonym)|uniprotkb:Leucine-rich repeat and immunoglobulin domain-containing protein 1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514404|imex:IM-28561-1075	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_116197.4|refseq:NP_001288115.1|refseq:NP_001288116.1|refseq:NP_001288118.1|refseq:NP_001288120.1|refseq:NP_001288121.1|refseq:NP_001288123.1|refseq:NP_001288124.1|refseq:NP_001288126.1|refseq:NP_001288127.1|refseq:NP_001288128.1|refseq:NP_001288129.1|refseq:XP_011520420.1|refseq:XP_016878171.1|dip:DIP-60981N|ensembl:ENSG00000169783(gene)|ensembl:ENST00000355300(transcript)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031012"(extracellular matrix)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR026906|interpro:IPR032675|interpro:IPR036179|mint:Q96FE5|rcsb pdb:2ID5|rcsb pdb:4OQT|reactome:R-HSA-193634	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:Y6wLyY2T9DE19Yirc0l3YmZHdjA9606	rigid:ePku1Nwri8G8g/XBYklM2jOQ8Fw	false	sufficient binding region:791-1222	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q92628	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-720700|uniprotkb:A7E2D2|ensembl:ENSP00000303928|ensembl:ENSP00000413739	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:k0232_human(display_long)|uniprotkb:KIAA0232(gene name)|psi-mi:KIAA0232(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514395|imex:IM-28561-1073	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_001094060.1|refseq:NP_055558.2|ensembl:ENSG00000170871(gene)|ensembl:ENST00000307659(transcript)|ensembl:ENST00000425103(transcript)|go:"GO:0005524"(ATP binding)|interpro:IPR027871|mint:Q92628	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:eqsxcPMYtmnwREYkFJufsyLMqDo9606	rigid:ExqzCpx9QkDIkOsFvp4/dotgrw0	false	sufficient binding region:374-740	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:O75525	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-722504|uniprotkb:Q6NUL8|uniprotkb:Q9UPA8|ensembl:ENSP00000348108	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:khdr3_human(display_long)|uniprotkb:Sam68-like mammalian protein 2(gene name synonym)|uniprotkb:Sam68-like phosphotyrosine protein(gene name synonym)|uniprotkb:RNA-binding protein T-Star(gene name synonym)|uniprotkb:KHDRBS3(gene name)|psi-mi:KHDRBS3(display_short)|uniprotkb:SALP(gene name synonym)|uniprotkb:SLM2(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514386|imex:IM-28561-395	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_006549.1|ensembl:ENSG00000131773(gene)|ensembl:ENST00000355849(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0048024"(regulation of mRNA splicing, via spliceosome)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032335|interpro:IPR032571|interpro:IPR036612|mint:O75525|rcsb pdb:5EL3|rcsb pdb:5ELR|rcsb pdb:5ELS|rcsb pdb:5ELT|rcsb pdb:5EMO|reactome:R-HSA-8849468	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:9ZoB3JVp0Q9nxeFRsmWhNThzWoE9606	rigid:pLKEwyNio2dk53vXyu2U8REJyOI	false	sufficient binding region:791-1222	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:O75525	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-722504|uniprotkb:Q6NUL8|uniprotkb:Q9UPA8|ensembl:ENSP00000348108	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:khdr3_human(display_long)|uniprotkb:Sam68-like mammalian protein 2(gene name synonym)|uniprotkb:Sam68-like phosphotyrosine protein(gene name synonym)|uniprotkb:RNA-binding protein T-Star(gene name synonym)|uniprotkb:KHDRBS3(gene name)|psi-mi:KHDRBS3(display_short)|uniprotkb:SALP(gene name synonym)|uniprotkb:SLM2(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514377|imex:IM-28561-833	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_006549.1|ensembl:ENSG00000131773(gene)|ensembl:ENST00000355849(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0048024"(regulation of mRNA splicing, via spliceosome)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032335|interpro:IPR032571|interpro:IPR036612|mint:O75525|rcsb pdb:5EL3|rcsb pdb:5ELR|rcsb pdb:5ELS|rcsb pdb:5ELT|rcsb pdb:5EMO|reactome:R-HSA-8849468	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:9ZoB3JVp0Q9nxeFRsmWhNThzWoE9606	rigid:pLKEwyNio2dk53vXyu2U8REJyOI	false	sufficient binding region:791-1222	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q9Y219	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-946223|uniprotkb:Q9UE17|uniprotkb:Q9UE99|uniprotkb:Q9UNK8|uniprotkb:Q9Y6P9|uniprotkb:Q9Y6Q0|ensembl:ENSP00000328169	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:jag2_human(display_long)|uniprotkb:JAG2(gene name)|psi-mi:JAG2(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514368|imex:IM-28561-617	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_002217.3|refseq:NP_660142.1|ensembl:ENSG00000184916(gene)|ensembl:ENST00000331782(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003016"(respiratory system process)|go:"GO:0005112"(Notch binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008083"(growth factor activity)|go:"GO:0009912"(auditory receptor cell fate commitment)|go:"GO:0016331"(morphogenesis of embryonic epithelium)|go:"GO:0030154"(cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030217"(T cell differentiation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042492"(gamma-delta T cell differentiation)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:1990134"(epithelial cell apoptotic process involved in palatal shelf morphogenesis)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR001774("Delta/Serrate/lag-2 (DSL) protein")|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011651(Notch ligand, N-terminal)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR018097|interpro:IPR026219|mint:Q9Y219|rcsb pdb:5MW5|rcsb pdb:5MW7|rcsb pdb:5MWF|reactome:R-HSA-2122948|reactome:R-HSA-2644606|reactome:R-HSA-2660826|reactome:R-HSA-2691232|go:"GO:0005887"(integral component of plasma membrane)|reactome:R-HSA-2894862|reactome:R-HSA-2979096|reactome:R-HSA-9013507	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:GoH5Lw1zl+3dhA4RSpJTyQ0LY4Q9606	rigid:Nez+8u+sDHEHFC8qBS3SdEHHg84	false	sufficient binding region:791-1222	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q15811	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-602041|uniprotkb:B4DTM2|uniprotkb:O95216|uniprotkb:Q9UET5|uniprotkb:Q9UK60|uniprotkb:Q9UNK1|uniprotkb:Q9UNK2|uniprotkb:Q9UQ92|uniprotkb:Q1ED40|uniprotkb:Q0PW97|uniprotkb:E7ERJ1|uniprotkb:Q14BD3|uniprotkb:Q20BK3|intact:EBI-11029034|uniprotkb:A7Y322|uniprotkb:A8CTX8|uniprotkb:A8CTY3|uniprotkb:A8CTY7|uniprotkb:A8D7D0|uniprotkb:A8DCP3|uniprotkb:E9PE44|uniprotkb:E9PG01|uniprotkb:E9PHV2|uniprotkb:Q0PW94|uniprotkb:Q0PW95|intact:EBI-28971797|ensembl:ENSP00000370719	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:itsn1_human(display_long)|uniprotkb:SH3 domain-containing protein 1A(gene name synonym)|uniprotkb:SH3P17(gene name synonym)|uniprotkb:ITSN1(gene name)|psi-mi:ITSN1(display_short)|uniprotkb:ITSN(gene name synonym)|uniprotkb:SH3D1A(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514359|imex:IM-28561-831	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	ensembl:ENST00000381291|ensembl:ENSP00000370691|ensembl:ENSP00000370719|ensembl:ENST00000399338|ensembl:ENSP00000382275|ensembl:ENST00000399349|ensembl:ENSP00000382286|ensembl:ENSP00000382289|ensembl:ENST00000399353|ensembl:ENSP00000382290|ensembl:ENST00000399367|ensembl:ENSP00000382301|ensembl:ENST00000399352|refseq:NP_001001132.1|refseq:NP_003015.2|refseq:XP_011527994.1|refseq:XP_011527995.1|refseq:NP_001317938.1|refseq:NP_001317939.1|refseq:NP_001317940.1|refseq:NP_001317941.1|refseq:XP_016883917.1|refseq:XP_016883921.1|refseq:XP_016883922.1|refseq:XP_016883929.1|dip:DIP-33609N|ensembl:ENSG00000205726(gene)|ensembl:ENST00000381318(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006887"(exocytosis)|go:"GO:0006897"(endocytosis)|go:"GO:0007420"(brain development)|go:"GO:0015031"(protein transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0030027"(lamellipodium)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0055037"(recycling endosome)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060124"(positive regulation of growth hormone secretion)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0097440"(apical dendrite)|go:"GO:0098793"(presynapse)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0150007"(clathrin-dependent synaptic vesicle endocytosis)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2001288"(positive regulation of caveolin-mediated endocytosis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000261("EPS15 homology (EH)")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018247|interpro:IPR035892|interpro:IPR035899|interpro:IPR036028|mint:Q15811|rcsb pdb:1KI1|rcsb pdb:2KGR|rcsb pdb:2KHN|rcsb pdb:3FIA|rcsb pdb:3QBV|rcsb pdb:4IIM|rcsb pdb:5HZI|rcsb pdb:5HZJ|rcsb pdb:5HZK|rcsb pdb:6GBU|rcsb pdb:6H5T|reactome:R-HSA-193648|reactome:R-HSA-3928662|reactome:R-HSA-416482|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9013148|reactome:R-HSA-9013406|reactome:R-HSA-9013408	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:gYC3xiyk4dbnCXhZ8Rzn3rzafyU9606	rigid:wKAVpxRUsQ0v4A3QsSzkVVv5o+4	false	sufficient binding region:791-1222	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:O95965	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-26514313|ensembl:ENSP00000365351|uniprotkb:A8K5M5|uniprotkb:B3KTP1|uniprotkb:B4DQ02|uniprotkb:Q8N172|uniprotkb:Q9NPR0	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:itgbl_human(display_long)|uniprotkb:ITGBL1(gene name)|psi-mi:ITGBL1(display_short)|uniprotkb:OSCP(gene name synonym)|uniprotkb:TIED(gene name synonym)|uniprotkb:Osteoblast-specific cysteine-rich protein(gene name synonym)|uniprotkb:Ten integrin EGF-like repeat domain-containing protein(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514350|imex:IM-28561-829	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	ensembl:ENSG00000198542(gene)|ensembl:ENST00000376180(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0033627"(cell adhesion mediated by integrin)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR013111(EGF, extracellular)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR027070|mint:O95965|reactome:R-HSA-8941332|refseq:NP_001258683.1|refseq:NP_001258684.1|refseq:NP_001258685.1|refseq:NP_004782.1|refseq:XP_005254157.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:ePQLRokUrwfykDDEZPX0lYFQ6WE9606	rigid:ZvCU4PE0b5Scf0Pan+fIVpRhqNM	false	sufficient binding region:791-1222	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q9P2J2	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-718292|ensembl:ENSP00000357073	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:tutla_human(display_long)|uniprotkb:IGSF9A(gene name synonym)|uniprotkb:NRT1(gene name synonym)|uniprotkb:Immunoglobulin superfamily member 9A(gene name synonym)|uniprotkb:IGSF9(gene name)|psi-mi:IGSF9(display_short)|uniprotkb:KIAA1355(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514304|imex:IM-28561-615	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_001128522.1|refseq:NP_065840.2|ensembl:ENSG00000085552(gene)|ensembl:ENST00000368094(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007411"(axon guidance)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0060077"(inhibitory synapse)|go:"GO:0070593"(dendrite self-avoidance)|go:"GO:0098632"(cell-cell adhesion mediator activity)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR036179|interpro:IPR043204|mint:Q9P2J2|rcsb pdb:1V5J	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:H29I92kZumu9TyHmhfBUzPEiXXg9606	rigid:FeyGx2xUMgBYl3kDU+yOZoteSrs	false	sufficient binding region:374-740	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q05084	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-1046751|uniprotkb:P78506|uniprotkb:Q13824|uniprotkb:A8K7U1|intact:EBI-3915169|uniprotkb:Q96HG3|uniprotkb:B3FTQ2|ensembl:ENSP00000379908|ensembl:ENSP00000385570|ensembl:ENSP00000385651	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:ica69_human(display_long)|uniprotkb:69 kDa islet cell autoantigen(gene name synonym)|uniprotkb:Islet cell autoantigen p69(gene name synonym)|uniprotkb:ICA1(gene name)|psi-mi:ICA1(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514295|imex:IM-28561-613	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_001129492.1|refseq:NP_004959.2|refseq:NP_071682.1|refseq:XP_011513647.1|refseq:XP_011513648.1|refseq:XP_011513649.1|refseq:XP_011513650.1|refseq:XP_011513651.1|refseq:NP_001263407.1|refseq:XP_005249792.1|ensembl:ENSG00000003147(gene)|ensembl:ENST00000396675(transcript)|ensembl:ENST00000402384(transcript)|ensembl:ENST00000406470(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006836"(neurotransmitter transport)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051049"(regulation of transport)|go:"GO:0140090"(membrane curvature sensor activity)|interpro:IPR006723(Islet cell autoantigen ICA69 homologue)|interpro:IPR010504(Arfaptin-like)|interpro:IPR024114|interpro:IPR027267|interpro:IPR030796|mint:Q05084|go:"GO:0019904"(protein domain specific binding)|refseq:XP_016867606.1|refseq:XP_016867607.1|refseq:XP_016867608.1|refseq:XP_016867609.1|refseq:XP_016867610.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:pVUULpiv0K4iNKkaK448C2ubSDo9606	rigid:4oEoYYj7ZOvVxWoTMDE+QWAJwBU	false	sufficient binding region:791-1222	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q9NSC5	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-748420|uniprotkb:O14580|uniprotkb:O95350|uniprotkb:Q9NSB9|uniprotkb:Q9NSC0|intact:EBI-2557809|uniprotkb:E9PCW9|uniprotkb:Q9NSC1|intact:EBI-28972925|ensembl:ENSP00000376162|ensembl:ENSP00000439937|ensembl:ENSP00000446026|intact:EBI-10175777|uniprotkb:B2RA10	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:home3_human(display_long)|uniprotkb:HOMER3(gene name)|psi-mi:HOMER3(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514286|imex:IM-28561-179	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	ensembl:ENST00000221222|ensembl:ENSP00000221222|ensembl:ENSP00000376162|ensembl:ENST00000433218|ensembl:ENSP00000396154|ensembl:ENSP00000439937|ensembl:ENSP00000446026|ensembl:ENST00000594439|ensembl:ENSP00000471835|refseq:XP_006723006.1|refseq:XP_006723007.1|refseq:NP_001139193.1|refseq:NP_001139194.1|refseq:NP_004829.3|refseq:NP_001139196.1|ensembl:ENSG00000051128(gene)|ensembl:ENST00000392351(transcript)|ensembl:ENST00000539827(transcript)|ensembl:ENST00000542541(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006605"(protein targeting)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030425"(dendrite)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0035256"(G protein-coupled glutamate receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:2001256"(regulation of store-operated calcium entry)|interpro:IPR000697(EVH1)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR044100|mint:Q9NSC5|rcsb pdb:2P8V|rcsb pdb:3CVF|reactome:R-HSA-6794361	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:U1y/y52nnf7zQUCNQlqk7JDgXi49606	rigid:3JIKVLGEKdfGowaVQiIcv6m0VnI	false	sufficient binding region:1219-1731	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:P61978	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-304185|intact:EBI-28971491|ensembl:ENSP00000317788|ensembl:ENSP00000353552|uniprotkb:Q07244|uniprotkb:Q15671|uniprotkb:Q59F98|uniprotkb:Q60577|uniprotkb:Q922Y7|uniprotkb:Q96J62|uniprotkb:Q5T6W4|intact:EBI-3440248|uniprotkb:Q6IBN1	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:hnrpk_human(display_long)|uniprotkb:HNRNPK(gene name)|psi-mi:HNRNPK(display_short)|uniprotkb:HNRPK(gene name synonym)|uniprotkb:Transformation up-regulated nuclear protein(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514277|imex:IM-28561-611	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	ensembl:ENSG00000165119(gene)|go:"GO:0010988"(regulation of low-density lipoprotein particle clearance)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0042802"(identical protein binding)|ensembl:ENST00000351839(transcript)|ensembl:ENST00000360384(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000785"(chromatin)|go:"GO:0002102"(podosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006396"(RNA processing)|go:"GO:0007165"(signal transduction)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0042995"(cell projection)|go:"GO:0045296"(cadherin binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048024"(regulation of mRNA splicing, via spliceosome)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1902165"(regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:1905599"(positive regulation of low-density lipoprotein receptor activity)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR012987(ROK, N-terminal)|interpro:IPR033090|interpro:IPR036612|mint:P61978|rcsb pdb:1J5K|rcsb pdb:1KHM|rcsb pdb:1ZZI|rcsb pdb:1ZZJ|go:"GO:0043066"(negative regulation of apoptotic process)|reactome:R-HSA-4570464|reactome:R-HSA-72163|reactome:R-HSA-72203|reactome:R-HSA-9610379|rcsb pdb:1ZZK|refseq:NP_002131.2|refseq:NP_112552.1|refseq:NP_112553.1|ensembl:ENSP00000317788|ensembl:ENSP00000353552|ensembl:ENST00000376263|ensembl:ENSP00000365439|ensembl:ENST00000376281|ensembl:ENSP00000365458|refseq:NP_001305115.1|refseq:NP_001305116.1|refseq:NP_001305117.1|refseq:XP_016870157.1|refseq:XP_005252017.1|refseq:XP_005252020.1|refseq:XP_005252022.1|dip:DIP-31805N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:YZQD5JJkHPUMtZ4XUA9fQkNfXzc9606	rigid:GTAJQ4Ed8Z2eV5423NzBrJQsSZo	false	sufficient binding region:1219-1731,791-1222	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:P07910	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-357966|uniprotkb:P22628|uniprotkb:Q53EX2|uniprotkb:Q59FD3|uniprotkb:Q5FWE8|uniprotkb:Q86SF8|uniprotkb:Q86U45|uniprotkb:Q96HK7|uniprotkb:Q96HM4|uniprotkb:Q96IY5|uniprotkb:Q9BTS3|uniprotkb:D3DS19|uniprotkb:D3DS22|intact:EBI-28976506|ensembl:ENSP00000404848|ensembl:ENSP00000451291|ensembl:ENSP00000452276	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:hnrpc_human(display_long)|uniprotkb:HNRNPC(gene name)|psi-mi:HNRNPC(display_short)|uniprotkb:HNRPC(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514268|imex:IM-28561-1753	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_001070910.1|refseq:NP_001070911.1|refseq:NP_004491.2|refseq:NP_112604.2|ensembl:ENSP00000404848|ensembl:ENST00000430246|ensembl:ENSP00000442816|ensembl:ENST00000553300|ensembl:ENSP00000450544|ensembl:ENSP00000451291|ensembl:ENST00000554969|ensembl:ENSP00000452276|ensembl:ENSP00000450725|ensembl:ENST00000555883|ensembl:ENSP00000450629|ensembl:ENST00000556628|ensembl:ENSP00000451652|ensembl:ENST00000556897|ensembl:ENSP00000451176|refseq:XP_011535010.1|refseq:XP_011535011.1|refseq:XP_011535012.1|refseq:XP_011535013.1|refseq:XP_011535014.1|refseq:XP_016876741.1|refseq:XP_016876742.1|dip:DIP-29854N|refseq:XP_006720188.1|ensembl:ENSG00000092199(gene)|ensembl:ENST00000420743(transcript)|ensembl:ENST00000554455(transcript)|ensembl:ENST00000557201(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000785"(chromatin)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0031492"(nucleosomal DNA binding)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043044"|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1990247"(N6-methyladenosine-containing RNA binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR017347(Heterogeneous nuclear ribonucleoprotein C, Raly)|interpro:IPR035979|mint:P07910|rcsb pdb:1TXP|rcsb pdb:1WF2|rcsb pdb:2MXY|rcsb pdb:2MZ1|rcsb pdb:3LN4|reactome:R-HSA-4570464|reactome:R-HSA-72163|reactome:R-HSA-72203|reactome:R-HSA-9013418|reactome:R-HSA-9013422	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:Fj5tiH0wrNUjTnsURIg8dB8laMg9606	rigid:b6H5gQgZa8WhsDfrX2GhWirnItU	false	sufficient binding region:791-1222	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:O14964	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-740220|uniprotkb:Q9NR36|ensembl:ENSP00000331201|ensembl:ENSP00000504106	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:hgs_human(display_long)|uniprotkb:Protein pp110(gene name synonym)|uniprotkb:Hrs(gene name synonym)|uniprotkb:HGS(gene name)|psi-mi:HGS(display_short)|uniprotkb:HRS(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514259|imex:IM-28561-1059	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_004703.1|dip:DIP-29050N|ensembl:ENSG00000185359(gene)|ensembl:ENST00000329138(transcript)|ensembl:ENST00000676546(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0007165"(signal transduction)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010324"(membrane invagination)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0016197"(endosomal transport)|go:"GO:0016236"(macroautophagy)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0033565"(ESCRT-0 complex)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0036258"(multivesicular body assembly)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043405"(regulation of MAP kinase activity)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0097013"(phagocytic vesicle lumen)|go:"GO:1903543"(positive regulation of exosomal secretion)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR002014(VHS)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR008942(ENTH/VHS)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017073(Ubiquitin binding protein, Hrs/VPS27)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR024641|mint:O14964|rcsb pdb:2D3G|rcsb pdb:3F1I|rcsb pdb:3OBQ|rcsb pdb:3ZYQ|rcsb pdb:4AVX|reactome:R-HSA-182971|reactome:R-HSA-432720|reactome:R-HSA-5689880|reactome:R-HSA-6807004|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-9013420|reactome:R-HSA-917729|reactome:R-HSA-9635644|reactome:R-HSA-9636383|reactome:R-HSA-9706019	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:z/AnREuqEpyJ9/Zj6JFCJCJem1I9606	rigid:IhEppBWiWyG0QdLpTfEaSegGnck	false	sufficient binding region:374-740	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q76N89	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-949582|ensembl:ENSP00000379228|uniprotkb:O15036|uniprotkb:Q9HCC7|uniprotkb:A7E2X0|uniprotkb:A8MYS3|uniprotkb:B4DH42|intact:EBI-11059486	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:hecw1_human(display_long)|uniprotkb:HECT, C2 and WW domain-containing protein 1(gene name synonym)|uniprotkb:NEDD4-like E3 ubiquitin-protein ligase 1(gene name synonym)|uniprotkb:HECW1(gene name)|psi-mi:HECW1(display_short)|uniprotkb:KIAA0322(gene name synonym)|uniprotkb:NEDL1(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HECW1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514250|imex:IM-28561-393	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR032348|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|interpro:IPR037795|interpro:IPR040524|mint:Q76N89|rcsb pdb:3L4H|reactome:R-HSA-4641258|ensembl:ENSG00000002746(gene)|ensembl:ENST00000395891(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0061630"(ubiquitin protein ligase activity)|refseq:NP_055867.3|refseq:NP_001273988.1|refseq:XP_016867375.1|refseq:XP_016867378.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:iK0wuIJT5WCj76JVf435fZeARkc9606	rigid:pvI/zNpHxtaEc1sMAJe19t095V0	false	sufficient binding region:791-1222	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q16775	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-3905342|uniprotkb:B4DP33|uniprotkb:E7EN93|uniprotkb:A8K290|uniprotkb:B4DRA7|ensembl:ENSP00000380514	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:glo2_human(display_long)|uniprotkb:HAGH(gene name)|psi-mi:HAGH(display_short)|uniprotkb:GLO2(gene name synonym)|uniprotkb:HAGH1(gene name synonym)|uniprotkb:Glyoxalase II(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514241|imex:IM-28561-391	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_001273178.1|refseq:XP_011520772.1|refseq:NP_001035517.1|refseq:NP_005317.2|ensembl:ENSG00000063854(gene)|ensembl:ENST00000397356(transcript)|go:"GO:0004416"(hydroxyacylglutathione hydrolase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006750"(glutathione biosynthetic process)|go:"GO:0019243"(methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione)|go:"GO:0046872"(metal ion binding)|interpro:IPR001279(Beta-lactamase-like)|interpro:IPR017782(Hydroxyacylglutathione hydrolase)|interpro:IPR032282|interpro:IPR035680|interpro:IPR036866|mint:Q16775|rcsb pdb:1QH3|rcsb pdb:1QH5|rcsb pdb:2F50|reactome:R-HSA-70268	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:TFSITQbz0iBYpl6RoIByieFUbdE9606	rigid:7+2diFiagHy6PQupmG//RzTedwg	false	sufficient binding region:374-740	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:P28799	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-747754|uniprotkb:P23781|uniprotkb:P23782|uniprotkb:P23783|uniprotkb:P23784|uniprotkb:Q9BWE7|uniprotkb:Q9UCH0|ensembl:ENSP00000053867|uniprotkb:Q53Y88|uniprotkb:Q540U8|uniprotkb:D3DX55|uniprotkb:Q53HQ8|uniprotkb:Q9H8S1	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:grn_human(display_long)|uniprotkb:Proepithelin(gene name synonym)|uniprotkb:GRN(gene name)|psi-mi:GRN(display_short)|uniprotkb:Acrogranin(gene name synonym)|uniprotkb:Epithelin precursor(gene name synonym)|uniprotkb:Glycoprotein of 88 Kda(gene name synonym)|uniprotkb:Granulin precursor(gene name synonym)|uniprotkb:PC cell-derived growth factor(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514232|imex:IM-28561-1533	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_002078.1|ensembl:ENSG00000030582(gene)|ensembl:ENST00000053867(transcript)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0003723"(RNA binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007040"(lysosome organization)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048680"(positive regulation of axon regeneration)|refseq:XP_005257310.1|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0060266"(negative regulation of respiratory burst involved in inflammatory response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0106016"(positive regulation of inflammatory response to wounding)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1902564"(negative regulation of neutrophil activation)|go:"GO:1903334"(positive regulation of protein folding)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1905247"(positive regulation of aspartic-type peptidase activity)|go:"GO:1905673"(positive regulation of lysosome organization)|interpro:IPR000118(Granulin)|interpro:IPR037277|interpro:IPR039036|mint:P28799|rcsb pdb:1G26|rcsb pdb:2JYE|rcsb pdb:2JYT|rcsb pdb:2JYU|rcsb pdb:2JYV|rcsb pdb:6NUG|reactome:R-HSA-6798695|dip:DIP-41742N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:SaujQCj7wHfPYunGzgTgG+jQgA89606	rigid:KWYG6CN3pH7NLXlWlLFGKjiv/C0	false	sufficient binding region:1219-1731,791-1222	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q13098	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-725197|uniprotkb:Q8NA10|uniprotkb:Q9BWL1|ensembl:ENSP00000302873	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:csn1_human(display_long)|uniprotkb:JAB1-containing signalosome subunit 1(gene name synonym)|uniprotkb:G protein pathway suppressor 1(gene name synonym)|uniprotkb:Protein MFH(gene name synonym)|uniprotkb:GPS1(gene name)|psi-mi:GPS1(display_short)|uniprotkb:COPS1(gene name synonym)|uniprotkb:CSN1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514223|imex:IM-28561-827	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_004118.3|refseq:NP_997657.1|ensembl:ENSG00000169727(gene)|ensembl:ENST00000306823(transcript)|go:"GO:0000188"(obsolete inactivation of MAPK activity)|go:"GO:0000338"(protein deneddylation)|go:"GO:0005095"(GTPase inhibitor activity)|go:"GO:0005654"(nucleoplasm)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR019585|interpro:IPR033008|interpro:IPR036390|mint:Q13098|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4WSN|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|rcsb pdb:6R7N|go:"GO:0005829"(cytosol)|go:"GO:0007254"(JNK cascade)|go:"GO:0008180"(COP9 signalosome)|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664|reactome:R-HSA-9013422|refseq:NP_001308021.1|refseq:XP_016880023.1|dip:DIP-42077N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:OMWZ67qcgKTM0R/hy8L2oCa3cpo9606	rigid:3LXsfAtL3FHpsZOcm9nHIQgnbiU	false	sufficient binding region:374-740	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q16538	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-22387200|ensembl:ENSP00000311528|uniprotkb:Q16664|uniprotkb:Q59EH5|uniprotkb:Q66K56	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:gp162_human(display_long)|uniprotkb:GPR162(gene name)|psi-mi:GPR162(display_short)|uniprotkb:GRCA(gene name synonym)|uniprotkb:Gene-rich cluster gene A protein(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514214|imex:IM-28561-825	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	ensembl:ENST00000311268(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|interpro:IPR022347|interpro:IPR022348|mint:Q16538|ensembl:ENSG00000250510(gene)|refseq:NP_055264.1|refseq:NP_062832.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:eatw70/QC/A22uW5PuQ2x2b9rTU9606	rigid:Zb4+T971Hy5GwlDw5fTQiVGQkrA	false	sufficient binding region:791-1222	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:P17174	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-727329|uniprotkb:Q5VW80|uniprotkb:B2R6R7|ensembl:ENSP00000359539|uniprotkb:B7Z7E9	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:aatc_human(display_long)|uniprotkb:Transaminase A(gene name synonym)|uniprotkb:Glutamate oxaloacetate transaminase 1(gene name synonym)|uniprotkb:GOT1(gene name)|psi-mi:GOT1(display_short)|uniprotkb:Cysteine aminotransferase, cytoplasmic(gene name synonym)|uniprotkb:Cysteine transaminase, cytoplasmic(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514205|imex:IM-28561-177	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	ensembl:ENSG00000120053(gene)|refseq:NP_002070.1|ensembl:ENST00000370508(transcript)|go:"GO:0004069"("L-aspartate:2-oxoglutarate aminotransferase activity")|go:"GO:0004609"(phosphatidylserine decarboxylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0006103"(2-oxoglutarate metabolic process)|go:"GO:0006107"(oxaloacetate metabolic process)|go:"GO:0006114"(glycerol biosynthetic process)|go:"GO:0006531"(aspartate metabolic process)|go:"GO:0006532"(aspartate biosynthetic process)|go:"GO:0006533"(aspartate catabolic process)|go:"GO:0006536"(glutamate metabolic process)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0019550"(glutamate catabolic process to aspartate)|go:"GO:0019551"(glutamate catabolic process to 2-oxoglutarate)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060290"(transdifferentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:1990267"(response to transition metal nanoparticle)|interpro:IPR000796(Aspartate/other aminotransferase)|interpro:IPR004838(Aminotransferases, class-I, pyridoxal-phosphate-binding site)|interpro:IPR004839(Aminotransferase, class I and II)|interpro:IPR015421(Pyridoxal phosphate-dependent transferase, major region, subdomain 1)|interpro:IPR015422(Pyridoxal phosphate-dependent transferase, major region, subdomain 2)|interpro:IPR015424(Pyridoxal phosphate-dependent transferase, major region)|mint:P17174|rcsb pdb:3II0|rcsb pdb:3WZF|rcsb pdb:6DNA|rcsb pdb:6DNB|rcsb pdb:6DND|rcsb pdb:6LIG|reactome:R-HSA-1237112|reactome:R-HSA-70263|reactome:R-HSA-8963693|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031406"(carboxylic acid binding)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032966"(negative regulation of collagen biosynthetic process)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0043679"(axon terminus)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0047801"(L-cysteine transaminase activity)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051902"(negative regulation of mitochondrial depolarization)	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:8rKeP2uuw8vYS5QTqOv46SufdM89606	rigid:7RZ5uDxNNRnfUCIQi3NC7AxhQhk	false	sufficient binding region:374-740	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:O94915	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-1104821|uniprotkb:O95640|uniprotkb:Q8WTZ5|uniprotkb:Q9NT40|intact:EBI-1058548|intact:EBI-28979815|ensembl:ENSP00000351113	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:fryl_human(display_long)|uniprotkb:FRYL(gene name)|psi-mi:FRYL(display_short)|uniprotkb:AF4P12(gene name synonym)|uniprotkb:KIAA0826(gene name synonym)|uniprotkb:ALL1-fused gene from chromosome 4p12 protein(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514186|imex:IM-28561-173	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_055845.1|ensembl:ENST00000358350(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0005938"(cell cortex)|go:"GO:0030427"(site of polarized growth)|go:"GO:0031175"(neuron projection development)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025481|interpro:IPR025614|interpro:IPR029473|interpro:IPR039867|ensembl:ENSG00000075539(gene)|mint:O94915|ensembl:ENSP00000351113|refseq:XP_016863535.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:hShMhfhMFUzhUCC/9QfVMnOB7AA9606	rigid:5gyXHmpkacs1DxJZfXhk8PRiOp8	false	sufficient binding region:374-740	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:O43559	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-725515|uniprotkb:Q5T3D5|ensembl:ENSP00000259748|ensembl:ENSP00000362109	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:frs3_human(display_long)|uniprotkb:Suc1-associated neurotrophic factor target 2(gene name synonym)|uniprotkb:FGFR-signaling adaptor SNT2(gene name synonym)|uniprotkb:FRS3(gene name)|psi-mi:FRS3(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514177|imex:IM-28561-1751	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_006644.1|refseq:XP_011512556.1|refseq:XP_011512557.1|ensembl:ENSG00000137218(gene)|ensembl:ENST00000373018(transcript)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR038742|mint:O43559|rcsb pdb:2KUP|rcsb pdb:2KUQ|rcsb pdb:2YS5|rcsb pdb:2YT2|reactome:R-HSA-5654693|reactome:R-HSA-5654700|reactome:R-HSA-5654706|reactome:R-HSA-5654712|reactome:R-HSA-5673001|reactome:R-HSA-9028731|reactome:R-HSA-9696270|reactome:R-HSA-9696273|ensembl:ENST00000259748(transcript)	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:eCZ788A2H+vRLOcEBvCcThCFoks9606	rigid:QNWDOmxRPVZqRmjSSjNODsfBxfQ	false	sufficient binding region:791-1222	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:P21333	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-350432|uniprotkb:Q8NF52|intact:EBI-1103234|ensembl:ENSP00000358866|uniprotkb:Q5HY53|uniprotkb:Q5HY55|uniprotkb:E9KL45	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:flna_human(display_long)|uniprotkb:FLNA(gene name)|psi-mi:FLNA(display_short)|uniprotkb:FLN(gene name synonym)|uniprotkb:FLN1(gene name synonym)|uniprotkb:Alpha-filamin(gene name synonym)|uniprotkb:Filamin-1(gene name synonym)|uniprotkb:Endothelial actin-binding protein(gene name synonym)|uniprotkb:Actin-binding protein 280(gene name synonym)|uniprotkb:Non-muscle filamin(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514168|imex:IM-28561-1749	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	go:"GO:0007195"(adenylate cyclase-inhibiting dopamine receptor signaling pathway)|go:"GO:1902396"(protein localization to bicellular tight junction)|refseq:NP_001104026.1|refseq:NP_001447.2|ensembl:ENSG00000196924(gene)|ensembl:ENST00000369850(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048680"(positive regulation of axon regeneration)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051015"(actin filament binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0051764"(actin crosslink formation)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090042"(tubulin deacetylation)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0097368"(establishment of Sertoli cell barrier)|go:"GO:0097440"(apical dendrite)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901381"(positive regulation of potassium ion transmembrane transport)|go:"GO:0046332"(SMAD binding)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016479"(negative regulation of transcription by RNA polymerase I)|go:"GO:0019900"(kinase binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0021943"(formation of radial glial scaffolds)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030018"(Z disc)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031523"(Myb complex)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031852"(mu-type opioid receptor binding)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0032432"(actin filament bundle)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034988"(Fc-gamma receptor I complex binding)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043113"(receptor clustering)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045296"(cadherin binding)|reactome:R-HSA-114608|reactome:R-HSA-430116|reactome:R-HSA-446353|reactome:R-HSA-5627123|reactome:R-HSA-8983711|rcsb pdb:6EW1|go:"GO:1905031"(regulation of membrane repolarization during cardiac muscle cell action potential)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2001046"(positive regulation of integrin-mediated signaling pathway)|go:"GO:2001224"(positive regulation of neuron migration)|interpro:IPR001298(Filamin/ABP280 repeat)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR036872|interpro:IPR044801|mint:P21333|rcsb pdb:2AAV|rcsb pdb:2BP3|rcsb pdb:2BRQ|rcsb pdb:2J3S|rcsb pdb:2JF1|rcsb pdb:2K3T|rcsb pdb:2K7P|rcsb pdb:2K7Q|rcsb pdb:2MTP|rcsb pdb:2W0P|rcsb pdb:2WFN|rcsb pdb:3CNK|rcsb pdb:3HOC|rcsb pdb:3HOP|rcsb pdb:3HOR|rcsb pdb:3ISW|rcsb pdb:3RGH|rcsb pdb:4M9P|rcsb pdb:4P3W|rcsb pdb:5XR1|rcsb pdb:6D8C|go:"GO:1905000"(regulation of membrane repolarization during atrial cardiac muscle cell action potential)|dip:DIP-1136N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:ZxGK5OSMy8cNsyt7Ax2KXb8bn9M9606	rigid:1S47v09Mf/PKE3ImjqAgNM+IgwI	false	sufficient binding region:1219-1731	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q14318	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-724839|uniprotkb:Q53GU3|uniprotkb:Q7Z349|uniprotkb:Q86YK6|ensembl:ENSP00000222308|ensembl:ENSP00000472302|uniprotkb:C8C9T5	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:fkbp8_human(display_long)|uniprotkb:FK506-binding protein 8(gene name synonym)|uniprotkb:38 kDa FK506-binding protein(gene name synonym)|uniprotkb:FKBPR38(gene name synonym)|uniprotkb:FKBP8(gene name)|psi-mi:FKBP8(display_short)|uniprotkb:FKBP38(gene name synonym)|uniprotkb:Rotamase(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514159|imex:IM-28561-1747	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_036313.3|refseq:NP_001295302.1|go:"GO:0001708"(cell fate specification)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006915"(apoptotic process)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0046872"(metal ion binding)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|mint:Q14318|ensembl:ENSG00000105701(gene)|rcsb pdb:2AWG|rcsb pdb:2D9F|rcsb pdb:2F2D|rcsb pdb:2MF9|rcsb pdb:3EY6|rcsb pdb:5MGX|reactome:R-HSA-5689880|ensembl:ENST00000222308(transcript)|ensembl:ENST00000596558(transcript)|refseq:XP_011526165.1|dip:DIP-42200N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:CpZqwry5szPluwNMwWXshCIMUvY9606	rigid:6JcW8shsXtT/mryDFFNdY3Fdoo0	false	sufficient binding region:791-1222	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q9Y3I1	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-1161222|uniprotkb:Q5TGC4|uniprotkb:Q96HM6|uniprotkb:Q9UF21|uniprotkb:Q9UKT2|uniprotkb:B4DNB3|ensembl:ENSP00000266087|uniprotkb:B4DWX5|uniprotkb:Q5TI86	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:fbx7_human(display_long)|uniprotkb:FBXO7(gene name)|psi-mi:FBXO7(display_short)|uniprotkb:FBX7(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514150|imex:IM-28561-609	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_001028196.1|refseq:NP_036311.3|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045620"(negative regulation of lymphocyte differentiation)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0097409"(glial cytoplasmic inclusion)|go:"GO:0097414"(classical Lewy body)|go:"GO:0097462"(Lewy neurite)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1990037"(Lewy body core)|go:"GO:1990038"(Lewy body corona)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR021625|interpro:IPR029071|interpro:IPR036047|mint:Q9Y3I1|rcsb pdb:4L9C|rcsb pdb:4L9H|reactome:R-HSA-8951664|reactome:R-HSA-983168|go:"GO:1903208"(negative regulation of hydrogen peroxide-induced neuron death)|ensembl:ENSG00000100225(gene)|ensembl:ENST00000266087(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|refseq:NP_001244919.1|dip:DIP-36125N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:i2Mqtw28fJTLURYC+gwr6bcjBoY9606	rigid:UcMZe7iBDQivbKvEFE/A7ECdxpA	false	sufficient binding region:1219-1731	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:A1XBS5	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-2349888|uniprotkb:Q96L09|uniprotkb:Q6AHW7|uniprotkb:A1XBS4|uniprotkb:Q8N8R1|uniprotkb:Q32ND3|ensembl:ENSP00000429367	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:fa92a_human(display_long)|uniprotkb:FAM92A(gene name)|psi-mi:FAM92A(display_short)|uniprotkb:FAM92A1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514141|imex:IM-28561-171	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_001269963.1|refseq:NP_660312.2|ensembl:ENSG00000188343(gene)|ensembl:ENST00000518322(transcript)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005814"(centriole)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0035108"(limb morphogenesis)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0060271"(cilium assembly)|go:"GO:0061024"(membrane organization)|go:"GO:0097546"(ciliary base)|go:"GO:0097749"(membrane tubulation)|interpro:IPR009602(Protein of unknown function DUF1208)|interpro:IPR027267|interpro:IPR035590|mint:A1XBS5	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:okcFZHR4G4vduKkWaZ0jXyRVZmY9606	rigid:YHYjpTPQQRG3YcscqruxcVwi49U	false	sufficient binding region:1219-1731	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:O94988	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-10962518|ensembl:ENSP00000264344|uniprotkb:Q8NBA3|uniprotkb:Q24JP0|uniprotkb:Q5PR21|uniprotkb:B4DLC1	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:fa13a_human(display_long)|uniprotkb:FAM13A(gene name)|psi-mi:FAM13A(display_short)|uniprotkb:FAM13A1(gene name synonym)|uniprotkb:KIAA0914(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514132|imex:IM-28561-389	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_001015045.1|refseq:NP_001252507.1|refseq:NP_001252508.1|refseq:NP_001252509.1|refseq:NP_055698.2|refseq:XP_011529818.1|ensembl:ENSG00000138640(gene)|ensembl:ENST00000264344(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000198(RhoGAP)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR039102|mint:O94988|reactome:R-HSA-8980692|reactome:R-HSA-9013149	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:Uwm2VF+xwj4Rc5+KKfgBh7l/M6I9606	rigid:Bxoez8lr508QGM2cfqj5SR1k1eY	false	sufficient binding region:1219-1731	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:O43414	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-9679612|uniprotkb:B1AK98|uniprotkb:Q5T2T7|uniprotkb:Q5T2T9|uniprotkb:Q5TG35|uniprotkb:Q9BQA0|uniprotkb:Q9UEB4|ensembl:ENSP00000361331	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:eri3_human(display_long)|uniprotkb:ERI3(gene name)|psi-mi:ERI3(display_short)|uniprotkb:PINT1(gene name synonym)|uniprotkb:PRNPIP(gene name synonym)|uniprotkb:PRNPIP1(gene name synonym)|uniprotkb:Prion interactor 1(gene name synonym)|uniprotkb:Prion protein-interacting protein(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514123|imex:IM-28561-1531	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_001288627.1|refseq:NP_001288628.1|refseq:NP_001288629.1|refseq:NP_001288630.1|ensembl:ENSP00000361331|ensembl:ENST00000372259|ensembl:ENSP00000361333|refseq:NP_076971.1|ensembl:ENSG00000117419(gene)|ensembl:ENST00000372257(transcript)|go:"GO:0000175"(3'-5'-exoribonuclease activity)|go:"GO:0000467"("exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0003723"(RNA binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR013520(Exonuclease, RNase T and DNA polymerase III)|interpro:IPR036397|mint:O43414|rcsb pdb:2XRI	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:Ke3BT8EH5uiVr+FunIbBBwvh/bM9606	rigid:5yvQI0mM7w4gO5vTtBOVSrKRVeE	false	sufficient binding region:791-1222	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q15717	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-374260|uniprotkb:Q9BTT1|ensembl:ENSP00000385269|ensembl:ENSP00000472197|intact:EBI-6190219|uniprotkb:B4DVB8|uniprotkb:Q53XN6	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:elav1_human(display_long)|uniprotkb:ELAVL1(gene name)|psi-mi:ELAVL1(display_short)|uniprotkb:HUR(gene name synonym)|uniprotkb:Hu-antigen R(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514114|imex:IM-28561-607	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	go:"GO:0006606"(protein import into nucleus)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0016441"(posttranscriptional gene silencing)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035198"(miRNA binding)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0060965"(negative regulation of gene silencing by miRNA)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|ensembl:ENSG00000066044(gene)|ensembl:ENST00000407627(transcript)|ensembl:ENST00000596459(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|refseq:NP_001410.2|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000036"(regulation of stem cell population maintenance)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002343(Paraneoplastic encephalomyelitis antigen)|interpro:IPR006548(Splicing factor ELAV/HuD)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034775|interpro:IPR034996|interpro:IPR035979|mint:Q15717|rcsb pdb:3HI9|rcsb pdb:4ED5|rcsb pdb:4EGL|rcsb pdb:4FXV|rcsb pdb:5SZW|rcsb pdb:6G2K|rcsb pdb:6GC5|rcsb pdb:6GD1|rcsb pdb:6GD2|rcsb pdb:6GD3|reactome:R-HSA-450520|reactome:R-HSA-72163|dip:DIP-31291N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:PciL5KuvP+2aUUv9cv7gWScgbw89606	rigid:txyvt9+kcPi3HUYRagWgX/n8y+A	false	sufficient binding region:374-740	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q9Y6B2	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-1049975|uniprotkb:Q8N7I4|uniprotkb:Q9BZT9|uniprotkb:B2RD11|ensembl:ENSP00000431162	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:eid1_human(display_long)|uniprotkb:EID1(gene name)|psi-mi:EID1(display_short)|uniprotkb:C15orf3(gene name synonym)|uniprotkb:CRI1(gene name synonym)|uniprotkb:RBP21(gene name synonym)|uniprotkb:PNAS-22(orf name)|uniprotkb:PTD014(orf name)|uniprotkb:E1A-like inhibitor of differentiation 1(gene name synonym)|uniprotkb:CREBBP/EP300 inhibitory protein 1(gene name synonym)|uniprotkb:21 kDa pRb-associated protein(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514105|imex:IM-28561-1529	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_055150.1|ensembl:ENSG00000255302(gene)|ensembl:ENST00000530028(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007049"(cell cycle)|go:"GO:0030154"(cell differentiation)|go:"GO:0035034"(histone acetyltransferase regulator activity)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR033255|interpro:IPR033258|mint:Q9Y6B2|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:VPSCn0cgSMX+Pl+QwutWWqZseLQ9606	rigid:ehUtmAy95UcxGiDFxUfovZtaA2Q	false	sufficient binding region:374-740	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:O95967	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-743414|uniprotkb:O75967|uniprotkb:A8K7R4|uniprotkb:B3KM31|uniprotkb:B3KQT1|ensembl:ENSP00000309953|ensembl:ENSP00000435295	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:fbln4_human(display_long)|uniprotkb:Fibulin-4(gene name synonym)|uniprotkb:Protein UPH1(gene name synonym)|uniprotkb:EFEMP2(gene name)|psi-mi:EFEMP2(display_short)|uniprotkb:FBLN4(gene name synonym)|uniprotkb:UNQ200/PRO226(orf name)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514096|imex:IM-28561-1739	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_058634.4|ensembl:ENSG00000172638(gene)|ensembl:ENST00000307998(transcript)|ensembl:ENST00000531972(transcript)|go:"GO:0001527"(microfibril)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0008201"(heparin binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035904"(aorta development)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0048251"(elastic fiber assembly)|go:"GO:0060414"(aorta smooth muscle tissue morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071953"(elastic fiber)|go:"GO:0097084"(vascular associated smooth muscle cell development)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1904026"(regulation of collagen fibril organization)|go:"GO:1904028"(positive regulation of collagen fibril organization)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904831"(positive regulation of aortic smooth muscle cell differentiation)|go:"GO:1905609"(positive regulation of smooth muscle cell-matrix adhesion)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR018097|interpro:IPR026823|interpro:IPR026824|mint:O95967|rcsb pdb:2KL7|reactome:R-HSA-2129379|dip:DIP-34518N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:L8jMp8rFYb6DRRusfWgyd9zN2KI9606	rigid:MyYO43F4jpm/gGOSJurbxnLjy7g	false	sufficient binding region:791-1222	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q12805	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-536772|uniprotkb:Q541U7|uniprotkb:A8K3I4|uniprotkb:D6W5D2|ensembl:ENSP00000347596|ensembl:ENSP00000378058|uniprotkb:B4DW75	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:fbln3_human(display_long)|uniprotkb:Fibulin-3(gene name synonym)|uniprotkb:Fibrillin-like protein(gene name synonym)|uniprotkb:Extracellular protein S1-5(gene name synonym)|uniprotkb:EFEMP1(gene name)|psi-mi:EFEMP1(display_short)|uniprotkb:FBLN3(gene name synonym)|uniprotkb:FBNL(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514087|imex:IM-28561-823	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	ensembl:ENSG00000115380(gene)|ensembl:ENST00000355426(transcript)|ensembl:ENST00000394555(transcript)|go:"GO:0005006"(epidermal growth factor-activated receptor activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007601"(visual perception)|go:"GO:0008083"(growth factor activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0043010"(camera-type eye development)|go:"GO:0048048"(embryonic eye morphogenesis)|go:"GO:0048050"(post-embryonic eye morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR018097|interpro:IPR026823|interpro:IPR032973|mint:Q12805|reactome:R-HSA-2129379|refseq:NP_001034437.1|refseq:NP_001034438.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:V32dS+EEp5Syu3A6lQJal0fg6UM9606	rigid:WUzcnrG7myg9h1FXceWENEeA7eY	false	sufficient binding region:791-1222	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:P50570	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-346547|uniprotkb:Q7Z5S3|uniprotkb:Q5I0Y0|uniprotkb:Q9UPH4|intact:EBI-3959204|uniprotkb:A8K1B6|uniprotkb:E7EV30|uniprotkb:K7ESI9|intact:EBI-5912046|uniprotkb:E9PEQ4|ensembl:ENSP00000347890	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:dyn2_human(display_long)|uniprotkb:DNM2(gene name)|psi-mi:DNM2(display_short)|uniprotkb:DYN2(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514078|imex:IM-28561-605	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_004936.2|refseq:NP_001005360.1|refseq:NP_001005361.1|refseq:NP_001005362.1|refseq:NP_001177645.1|dip:DIP-31244N|reactome:R-HSA-203641|reactome:R-HSA-2132295|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-437239|reactome:R-HSA-8856828|reactome:R-HSA-9031628|reactome:R-HSA-196025|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031749"(D2 dopamine receptor binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033572"(transferrin transport)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044351"(macropinocytosis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050699"(WW domain binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0061024"(membrane organization)|go:"GO:0061025"(membrane fusion)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071245"(cellular response to carbon monoxide)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0098793"(presynapse)|go:"GO:0098844"(postsynaptic endocytic zone membrane)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902856"(negative regulation of non-motile cilium assembly)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903358"(regulation of Golgi organization)|go:"GO:1903408"("positive regulation of P-type sodium:potassium-exchanging transporter activity")|go:"GO:1903526"(negative regulation of membrane tubulation)|go:"GO:2000370"(positive regulation of clathrin-dependent endocytosis)|interpro:IPR000375(Dynamin central region)|interpro:IPR001401(Dynamin, GTPase region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR003130(Dynamin GTPase effector)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019762|interpro:IPR020850|interpro:IPR022812|interpro:IPR027188|interpro:IPR027417|interpro:IPR030381|mint:P50570|rcsb pdb:2YS1|reactome:R-HSA-166016|reactome:R-HSA-177504|reactome:R-HSA-190873|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008017"(microtubule binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016185"(synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|ensembl:ENSG00000079805(gene)|ensembl:ENST00000355667(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0001891"(phagocytic cup)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0003374"(dynamin family protein polymerization involved in mitochondrial fission)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005925"(focal adhesion)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0006897"(endocytosis)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:BAUEy6Iju72PTot46Xhz75cQTQs9606	rigid:8jpGnexWMe6rpHY1q1D5H8mk1uY	false	sufficient binding region:374-740	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q96EY1	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-356767|uniprotkb:O75472|uniprotkb:Q8WUJ6|uniprotkb:Q8WXJ3|uniprotkb:Q96D76|uniprotkb:Q96IV1|uniprotkb:Q9NYH8|uniprotkb:B2RAJ5|uniprotkb:B4DI33|uniprotkb:E7ES32|ensembl:ENSP00000262375|ensembl:ENSP00000477570	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:dnja3_human(display_long)|uniprotkb:DNAJA3(gene name)|psi-mi:DNAJA3(display_short)|uniprotkb:TID1(gene name synonym)|uniprotkb:HCA57(gene name synonym)|uniprotkb:Tumorous imaginal discs protein Tid56 homolog(gene name synonym)|uniprotkb:DnaJ protein Tid-1(gene name synonym)|uniprotkb:Hepatocellular carcinoma-associated antigen 57(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514069|imex:IM-28561-1519	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_001273445.1|refseq:NP_001128582.1|refseq:NP_005138.3|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060336"(negative regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0071340"(skeletal muscle acetylcholine-gated channel clustering)|go:"GO:0106137"(IkappaB kinase complex binding)|interpro:IPR001305(Heat shock protein DnaJ, cysteine-rich region)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR008971(HSP40/DnaJ peptide-binding)|interpro:IPR012724(Chaperone DnaJ)|interpro:IPR018253|interpro:IPR036410|interpro:IPR036869|mint:Q96EY1|rcsb pdb:2CTT|rcsb pdb:2DN9|rcsb pdb:6IWS|ensembl:ENSG00000103423(gene)|ensembl:ENSG00000276726(gene)|ensembl:ENST00000262375(transcript)|ensembl:ENST00000612103(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005133"(interferon-gamma receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006264"(mitochondrial DNA replication)|go:"GO:0006457"(protein folding)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006924"(activation-induced cell death of T cells)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0007569"(cell aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009408"(response to heat)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0030695"(GTPase regulator activity)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051059"(NF-kappaB binding)|dip:DIP-33870N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:WnRYdQ9E3yGbSlq1SSGTX9k+3uA9606	rigid:7e0FAEEeZZpTbBr978/8al2zhUg	false	sufficient binding region:1219-1731	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q9Y2H0	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-722139|uniprotkb:Q5QPG4|uniprotkb:Q5T2Y4|uniprotkb:Q5T2Y5|uniprotkb:Q9H137|uniprotkb:Q9H138|uniprotkb:Q9H1L7|uniprotkb:E1P5T5|ensembl:ENSP00000341633|ensembl:ENSP00000363014	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:dlgp4_human(display_long)|uniprotkb:SAPAP4(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 4(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 4(gene name synonym)|uniprotkb:DLGAP4(gene name)|psi-mi:DLGAP4(display_short)|uniprotkb:DAP4(gene name synonym)|uniprotkb:KIAA0964(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514060|imex:IM-28561-1737	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_001035951.1|refseq:NP_055717.2|refseq:NP_892118.1|refseq:XP_011526990.1|ensembl:ENSG00000080845(gene)|ensembl:ENST00000339266(transcript)|ensembl:ENST00000373907(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0023052"(signaling)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098981"(cholinergic synapse)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030527|mint:Q9Y2H0|reactome:R-HSA-6794361	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:i9/U52HQi00xnRUtJN0VZ0oXXwY9606	rigid:lmXGymlXWBfI7C+9toXShShlizc	false	sufficient binding region:374-740	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:O95886	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-1752541|uniprotkb:Q5TDD5|uniprotkb:Q9H3X7|ensembl:ENSP00000235180|ensembl:ENSP00000362444	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:dlgp3_human(display_long)|uniprotkb:DLGAP3(gene name)|psi-mi:DLGAP3(display_short)|uniprotkb:DAP3(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 3(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 3(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514051|imex:IM-28561-1291	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:XP_011540181.1|refseq:NP_001073887.1|ensembl:ENSG00000116544(gene)|ensembl:ENST00000235180(transcript)|ensembl:ENST00000373347(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0014069"(postsynaptic density)|go:"GO:0023052"(signaling)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098981"(cholinergic synapse)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030526|mint:O95886|reactome:R-HSA-6794361	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:Srxbe/eHss3qKoCFJes6yed29wQ9606	rigid:O+MxdmYv4vid/Qpa6wDfYFGp1S0	false	sufficient binding region:374-740	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:P04406	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-354056|uniprotkb:P00354|uniprotkb:Q53X65|uniprotkb:E7EUT4|ensembl:ENSP00000229239|ensembl:ENSP00000380068|ensembl:ENSP00000380070	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:g3p_human(display_long)|uniprotkb:GAPDH(gene name)|psi-mi:GAPDH(display_short)|uniprotkb:OK/SW-cl.12(orf name)|uniprotkb:CDABP0047(orf name)|uniprotkb:GAPD(gene name synonym)|uniprotkb:Peptidyl-cysteine S-nitrosylase GAPDH(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514195|imex:IM-28561-175	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_002037.2|refseq:NP_001243728.1|refseq:NP_001276674.1|refseq:NP_001276675.1|dip:DIP-32521N|go:"GO:0031965"(nuclear membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0035605"(peptidyl-cysteine S-nitrosylase activity)|go:"GO:0035606"(peptidyl-cysteine S-trans-nitrosylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050661"(NADP binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0050832"(defense response to fungus)|go:"GO:0051287"(NAD binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051873"(killing by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0097452"(GAIT complex)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR006424(Glyceraldehyde-3-phosphate dehydrogenase, type I)|interpro:IPR020828|interpro:IPR020829|interpro:IPR020830|interpro:IPR020831|interpro:IPR036291|mint:P04406|rcsb pdb:1U8F|rcsb pdb:1ZNQ|rcsb pdb:2FEH|rcsb pdb:3GPD|rcsb pdb:4WNC|rcsb pdb:4WNI|rcsb pdb:6ADE|rcsb pdb:6M61|rcsb pdb:6YND|rcsb pdb:6YNE|rcsb pdb:6YNF|rcsb pdb:6YNH|reactome:R-HSA-70171|reactome:R-HSA-70263|rcsb pdb:6IQ6|ensembl:ENSG00000111640(gene)|ensembl:ENST00000229239(transcript)|ensembl:ENST00000396859(transcript)|ensembl:ENST00000396861(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0004365"("glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0008017"(microtubule binding)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0031640"(killing of cells of another organism)	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:9YENN/dfKl/d0tJtfFyQp2o8eAc9606	rigid:e9zGMS9fGyJ2luGbEaobYaQ2EmU	false	sufficient binding region:1219-1731,374-740	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:P03923	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-1246099|uniprotkb:Q34774|uniprotkb:Q8HG30|intact:EBI-28985719|ensembl:ENSP00000354665	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:nu6m_human(display_long)|uniprotkb:MT-ND6(gene name)|psi-mi:MT-ND6(display_short)|uniprotkb:MTND6(gene name synonym)|uniprotkb:NADH6(gene name synonym)|uniprotkb:ND6(gene name synonym)|uniprotkb:NADH dehydrogenase subunit 6(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514530|imex:IM-28561-197	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:YP_003024037.1|ensembl:ENSP00000354665|ensembl:ENSG00000198695(gene)|ensembl:ENST00000361681(transcript)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0016021"(integral component of membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0035094"(response to nicotine)|go:"GO:0042220"(response to cocaine)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0070469"(respirasome)|interpro:IPR001457(NADH-ubiquinone/plastoquinone oxidoreductase, chain 6)|mint:P03923|rcsb pdb:5XTC|rcsb pdb:5XTD|reactome:R-HSA-611105|reactome:R-HSA-6799198	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:RuqWsG2c5WKw60frXqUSTzUY1c09606	rigid:9oW1JBgR9fI2MIwYcLDC0ugS+cA	false	sufficient binding region:1219-1731	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P00403	uniprotkb:Q9BYB0	intact:EBI-2105756|uniprotkb:Q37526|ensembl:ENSP00000354876	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	psi-mi:cox2_human(display_long)|uniprotkb:MT-CO2(gene name)|psi-mi:MT-CO2(display_short)|uniprotkb:COII(gene name synonym)|uniprotkb:COXII(gene name synonym)|uniprotkb:MTCO2(gene name synonym)|uniprotkb:Cytochrome c oxidase polypeptide II(gene name synonym)|uniprotkb:COX2(gene name synonym)	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514521|imex:IM-28561-1759	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:YP_003024029.1|ensembl:ENSG00000198712(gene)|ensembl:ENST00000361739(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0007595"(lactation)|go:"GO:0009409"(response to cold)|go:"GO:0010729"(positive regulation of hydrogen peroxide biosynthetic process)|go:"GO:0010940"(positive regulation of necrotic cell death)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042773"(ATP synthesis coupled electron transport)|go:"GO:0045277"(respiratory chain complex IV)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR001505("Copper centre Cu(A)")|interpro:IPR002429(Cytochrome c oxidase subunit II C-terminal)|interpro:IPR008972(Cupredoxin)|interpro:IPR011759(Cytochrome C oxidase subunit II, transmembrane region)|interpro:IPR014222(Cytochrome c oxidase, subunit II)|interpro:IPR034210|interpro:IPR036257|mint:P00403|rcsb pdb:3VRJ|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:NyMmciQe53E935KEZahz8cGPjIM9606	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rigid:lPIhy4Ae4rWLc3Lj8lOcP30vs2g	false	-	sufficient binding region:1219-1731	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q8TD10	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-2548751|ensembl:ENSP00000333539|ensembl:ENSP00000379589|ensembl:ENSP00000444254|ensembl:ENSP00000506738|uniprotkb:Q7Z3J0|uniprotkb:Q8IV14|uniprotkb:D3DSA4	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:mipo1_human(display_long)|uniprotkb:MIPOL1(gene name)|psi-mi:MIPOL1(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514512|imex:IM-28561-1537	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	ensembl:ENSG00000151338(gene)|ensembl:ENST00000327441(transcript)|ensembl:ENST00000396294(transcript)|ensembl:ENST00000537471(transcript)|ensembl:ENST00000684589(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|interpro:IPR026175|mint:Q8TD10|refseq:NP_001182225.1|refseq:NP_001182226.1|refseq:NP_620059.1|refseq:XP_016876492.1|refseq:XP_016876493.1|refseq:XP_016876494.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:X4gY7nzDtnrS2yil7QhmLH968Ug9606	rigid:ucZ5GgcMFIAXS8t9Os4hwGy3vPg	false	sufficient binding region:374-740	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:O75095	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-947597|uniprotkb:Q5VV39|uniprotkb:Q4AC86|ensembl:ENSP00000348982	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:megf6_human(display_long)|uniprotkb:MEGF6(gene name)|psi-mi:MEGF6(display_short)|uniprotkb:EGFL3(gene name synonym)|uniprotkb:KIAA0815(gene name synonym)|uniprotkb:Epidermal growth factor-like protein 3(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514503|imex:IM-28561-1295	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_001400.3|ensembl:ENSG00000162591(gene)|ensembl:ENST00000356575(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002049(EGF-like, laminin)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011489(EMI)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR018097|mint:O75095	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:/4HcLiv4UEW2qmvoV2OTj110y1I9606	rigid:k7XP33D6dveBhW42VYR+LPrXX0w	false	sufficient binding region:791-1222	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:A6BM72	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-947743|uniprotkb:Q17R86|uniprotkb:Q6UXS5|uniprotkb:Q8ND91|uniprotkb:Q96KG6|ensembl:ENSP00000386908|ensembl:ENSP00000414475	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:meg11_human(display_long)|uniprotkb:KIAA1781(gene name synonym)|uniprotkb:UNQ1949/PRO4432(orf name)|uniprotkb:MEGF11(gene name)|psi-mi:MEGF11(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514494|imex:IM-28561-1293	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_115821.2|refseq:XP_016878161.1|ensembl:ENSG00000157890(gene)|ensembl:ENST00000409699(transcript)|ensembl:ENST00000422354(transcript)|go:"GO:0010842"(retina layer formation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0034109"(homotypic cell-cell adhesion)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002049(EGF-like, laminin)|interpro:IPR011489(EMI)|interpro:IPR013032(EGF-like region, conserved site)|mint:A6BM72	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:weO+IOQ9YDdw/UpxHlfamFy2z8E9606	rigid:xNLtIucYqx1xamUxs2tHW9lThfw	false	sufficient binding region:791-1222	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q96KG7	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-308597|uniprotkb:Q68DE5|uniprotkb:Q8WUL3|ensembl:ENSP00000274473|ensembl:ENSP00000423354	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:meg10_human(display_long)|uniprotkb:MEGF10(gene name)|psi-mi:MEGF10(display_short)|uniprotkb:KIAA1780(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514485|imex:IM-28561-835	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	ensembl:ENSG00000145794(gene)|ensembl:ENST00000274473(transcript)|ensembl:ENST00000503335(transcript)|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0001891"(phagocytic cup)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005112"(Notch binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0014719"(skeletal muscle satellite cell activation)|go:"GO:0014816"(skeletal muscle satellite cell differentiation)|go:"GO:0014841"(skeletal muscle satellite cell proliferation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0033002"(muscle cell proliferation)|go:"GO:0034109"(homotypic cell-cell adhesion)|go:"GO:0042995"(cell projection)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:2000288"(positive regulation of myoblast proliferation)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002049(EGF-like, laminin)|interpro:IPR011489(EMI)|interpro:IPR013032(EGF-like region, conserved site)|mint:Q96KG7|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0043654"(recognition of apoptotic cell)|go:"GO:0048627"(myoblast development)|go:"GO:0048641"(regulation of skeletal muscle tissue development)|go:"GO:0051147"(regulation of muscle cell differentiation)|go:"GO:0051451"(myoblast migration)|go:"GO:0055001"(muscle cell development)|refseq:NP_115822.1|refseq:NP_001243474.1|refseq:NP_001295048.1|refseq:NP_001295050.1|refseq:XP_011541996.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:0clWGvvsCgEnPF4rD603WdFj8dY9606	rigid:/Rxmq+8zPRvRQJFKvNO8TYEoFe8	false	sufficient binding region:791-1222	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:P40926	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-721232|uniprotkb:O43682|uniprotkb:B4DE44|uniprotkb:E9PDB2|uniprotkb:A8K414|uniprotkb:B2RE78|ensembl:ENSP00000327070	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:mdhm_human(display_long)|uniprotkb:MDH2(gene name)|psi-mi:MDH2(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514476|imex:IM-28561-1757	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_005909.2|refseq:NP_001269332.1|refseq:NP_001269333.1|ensembl:ENSG00000146701(gene)|ensembl:ENST00000315758(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006107"(oxaloacetate metabolic process)|go:"GO:0006108"(malate metabolic process)|go:"GO:0006734"(NADH metabolic process)|go:"GO:0009060"(aerobic respiration)|go:"GO:0016020"(membrane)|go:"GO:0030060"(L-malate dehydrogenase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0046554"("malate dehydrogenase (NADP+) activity")|go:"GO:0070062"(extracellular exosome)|interpro:IPR001236(Lactate/malate dehydrogenase)|interpro:IPR001252(Malate dehydrogenase, active site)|interpro:IPR001557(L-lactate/malate dehydrogenase)|interpro:IPR010097(Malate dehydrogenase, NAD-dependent, eukaryotes and gamma proteobacteria)|interpro:IPR015955(Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal)|interpro:IPR022383|interpro:IPR036291|mint:P40926|rcsb pdb:2DFD|rcsb pdb:4WLE|rcsb pdb:4WLF|rcsb pdb:4WLN|rcsb pdb:4WLO|rcsb pdb:4WLU|rcsb pdb:4WLV|reactome:R-HSA-70263|reactome:R-HSA-71403	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:Ur2aO+2M7e/ftD8RlhPMHBc8/JU9606	rigid:V7h2AxLpthjnY3+mE95MoNRE/QA	false	sufficient binding region:791-1222	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q96EZ8	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-348259|ensembl:ENSP00000345358|ensembl:ENSP00000448056|uniprotkb:O14742|uniprotkb:O75497|uniprotkb:Q6VN53|uniprotkb:Q7Z372	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:mcrs1_human(display_long)|uniprotkb:MCRS1(gene name)|psi-mi:MCRS1(display_short)|uniprotkb:MSP58(gene name synonym)|uniprotkb:58 kDa microspherule protein(gene name synonym)|uniprotkb:Cell cycle-regulated factor p78(gene name synonym)|uniprotkb:MCRS2(gene name synonym)|uniprotkb:INO80Q(gene name synonym)|uniprotkb:INO80 complex subunit J(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514467|imex:IM-28561-635	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	ensembl:ENSG00000187778(gene)|ensembl:ENST00000343810(transcript)|ensembl:ENST00000550165(transcript)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005844"(polysome)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0010521"(telomerase inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0031011"(Ino80 complex)|go:"GO:0034046"("poly(G) binding")|go:"GO:0043204"(perikaryon)|go:"GO:0043981"(histone H4-K5 acetylation)|go:"GO:0043982"(histone H4-K8 acetylation)|go:"GO:0044545"(NSL complex)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0071339"(MLL1 complex)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1904751"(positive regulation of protein localization to nucleolus)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR025999|interpro:IPR037912|mint:Q96EZ8|reactome:R-HSA-3214847|go:"GO:0043984"(histone H4-K16 acetylation)|reactome:R-HSA-5689603|reactome:R-HSA-5696394|refseq:NP_001012300.1|refseq:NP_006328.2|refseq:NP_001265270.1|refseq:XP_005268629.1|refseq:XP_016874178.1|refseq:XP_016874179.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:b6u2XbKLMDkL1zbLTPBjq9J23Zs9606	rigid:u4ZPSOr4lQIddXJzzPAS3hBnraA	false	sufficient binding region:1219-1731	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:O15049	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-2512055|ensembl:ENSP00000274605|uniprotkb:Q7Z6I3|uniprotkb:B4DIL3|uniprotkb:D3DWP3|uniprotkb:Q6ZSQ6	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:n4bp3_human(display_long)|uniprotkb:N4BP3(gene name)|psi-mi:N4BP3(display_short)|uniprotkb:KIAA0341(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514552|imex:IM-28561-1297	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	ensembl:ENSG00000145911(gene)|ensembl:ENST00000274605(transcript)|go:"GO:0007399"(nervous system development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031410"(cytoplasmic vesicle)|interpro:IPR033571|mint:O15049|refseq:XP_011532775.1|refseq:XP_011532776.1|ensembl:ENSP00000274605|refseq:NP_055926.1|refseq:XP_006714897.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:rggbUyFRXczrPNjvyOUieC/Fj0c9606	rigid:emnO0Z9iRTrgIg+7G5YdMlun5UE	false	sufficient binding region:374-740	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q9NZQ3	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-745080|ensembl:ENSP00000294129|uniprotkb:B4DFL5|uniprotkb:Q6SPF3|uniprotkb:Q8TC10|uniprotkb:Q9UGM8|intact:EBI-957585|uniprotkb:Q6GU34	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:spn90_human(display_long)|uniprotkb:NCKIPSD(gene name)|psi-mi:NCKIPSD(display_short)|uniprotkb:AF3P21(gene name synonym)|uniprotkb:SPIN90(gene name synonym)|uniprotkb:54 kDa VacA-interacting protein(gene name synonym)|uniprotkb:54 kDa vimentin-interacting protein(gene name synonym)|uniprotkb:90 kDa SH3 protein interacting with Nck(gene name synonym)|uniprotkb:AF3p21(gene name synonym)|uniprotkb:Dia-interacting protein 1(gene name synonym)|uniprotkb:Diaphanous protein-interacting protein(gene name synonym)|uniprotkb:SH3 adapter protein SPIN90(gene name synonym)|uniprotkb:WASP-interacting SH3-domain protein(gene name synonym)|uniprotkb:Wiskott-Aldrich syndrome protein-interacting protein(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514561|imex:IM-28561-637	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	go:"GO:0007010"(cytoskeleton organization)|ensembl:ENSG00000213672(gene)|ensembl:ENST00000294129(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0006897"(endocytosis)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0017022"(myosin binding)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0071933"(Arp2/3 complex binding)|interpro:IPR001452(Src homology-3)|interpro:IPR018556|interpro:IPR030125|interpro:IPR035514|interpro:IPR036028|mint:Q9NZQ3|refseq:NP_057537.1|refseq:NP_909119.1|rcsb pdb:6DEC|rcsb pdb:6DED|rcsb pdb:6DEE|reactome:R-HSA-2029482|reactome:R-HSA-5663213|reactome:R-HSA-9664422	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:GPUSFE2sszpigAuSg81Cmk7HJCM9606	rigid:AecweRxWAU9ivnwfRsxmRxKIcbE	false	sufficient binding region:791-1222	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:P07196	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-475646|uniprotkb:Q16154|uniprotkb:B9ZVN2|uniprotkb:Q8IU72|ensembl:ENSP00000482169	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:nfl_human(display_long)|uniprotkb:Neurofilament triplet L protein(gene name synonym)|uniprotkb:68 kDa neurofilament protein(gene name synonym)|uniprotkb:NEFL(gene name)|psi-mi:NEFL(display_short)|uniprotkb:NF68(gene name synonym)|uniprotkb:NFL(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514570|imex:IM-28561-1299	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_006149.2|ensembl:ENSG00000277586(gene)|ensembl:ENST00000610854(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005883"(neurofilament)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0009636"(response to toxic substance)|go:"GO:0014012"(peripheral nervous system axon regeneration)|go:"GO:0019896"(axonal transport of mitochondrion)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021510"(spinal cord development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030424"(axon)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031133"(regulation of axon diameter)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0033693"(neurofilament bundle assembly)|go:"GO:0040011"(locomotion)|go:"GO:0042802"(identical protein binding)|go:"GO:0030426"(growth cone)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045105"(intermediate filament polymerization or depolymerization)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051258"(protein polymerization)|go:"GO:0051412"(response to corticosterone)|go:"GO:0060052"(neurofilament cytoskeleton organization)|go:"GO:0060074"(synapse maturation)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098981"(cholinergic synapse)|go:"GO:0099160"(postsynaptic intermediate filament cytoskeleton)|go:"GO:0099182"(presynaptic intermediate filament cytoskeleton)|go:"GO:0099184"(structural constituent of postsynaptic intermediate filament cytoskeleton)|go:"GO:1903935"(response to sodium arsenite)|go:"GO:1903937"(response to acrylamide)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|interpro:IPR027692|interpro:IPR039008|mint:P07196|reactome:R-HSA-438066|reactome:R-HSA-442982|reactome:R-HSA-5673001|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-9620244	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:tgdjWnqcql4YMbd89ujbDoqN/Yg9606	rigid:51USFszn8Py5snOoo37+xIuywro	false	sufficient binding region:374-740	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q99435	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-946274|intact:EBI-2845314|uniprotkb:B7Z2U7|uniprotkb:B7Z5Q4|uniprotkb:B7Z9J5|uniprotkb:B7Z9U3|uniprotkb:Q96JS2|ensembl:ENSP00000390680|ensembl:ENSP00000394612	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:nell2_human(display_long)|uniprotkb:NELL2(gene name)|psi-mi:NELL2(display_short)|uniprotkb:NRP2(gene name synonym)|uniprotkb:NEL-like protein 2(gene name synonym)|uniprotkb:Nel-related protein 2(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514579|imex:IM-28561-639	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_001138579.1|refseq:NP_001138580.1|refseq:NP_001138581.1|refseq:NP_001138582.1|refseq:NP_006150.1|refseq:XP_011536698.1|refseq:XP_005268962.1|dip:DIP-49927N|ensembl:ENSG00000184613(gene)|ensembl:ENST00000429094(transcript)|ensembl:ENST00000452445(transcript)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0008201"(heparin binding)|go:"GO:0070050"(neuron cellular homeostasis)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR001791(Laminin G)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR018097|mint:Q99435|rcsb pdb:6POG|reactome:R-HSA-428542	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:/NYlmX9iC3H17WXd+u97CVwOD7c9606	rigid:Ewvf+9pvleRibJBVahuxh05jt2E	false	sufficient binding region:1-417	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q9NPE2	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-2683432|uniprotkb:Q4V9L7|uniprotkb:Q9HBL4|uniprotkb:B2R6M8|ensembl:ENSP00000368389	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:ngrn_human(display_long)|uniprotkb:FI58G(gene name synonym)|uniprotkb:Mesenchymal stem cell protein DSC92(gene name synonym)|uniprotkb:Neurite outgrowth-associated protein(gene name synonym)|uniprotkb:Spinal cord-derived protein FI58G(gene name synonym)|uniprotkb:HT020(orf name)|uniprotkb:NGRN(gene name)|psi-mi:NGRN(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514588|imex:IM-28561-839	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_001028260.2|ensembl:ENSG00000182768(gene)|ensembl:ENST00000379095(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0016604"(nuclear body)|go:"GO:0019843"(rRNA binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0045171"(intercellular bridge)|go:"GO:0070131"(positive regulation of mitochondrial translation)|go:"GO:0072686"(mitotic spindle)|interpro:IPR010487(Neugrin)|mint:Q9NPE2	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:B0tJk1JglYD2jh37lUDOKV0qEBg9606	rigid:fWnHm4QzaiU1zYi+YmPQ6Yh8deo	false	sufficient binding region:791-1222	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q04721	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-2652733|uniprotkb:Q5T3X7|uniprotkb:Q99734|uniprotkb:Q9H240|ensembl:ENSP00000256646	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:notc2_human(display_long)|uniprotkb:NOTCH2(gene name)|psi-mi:NOTCH2(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514597|imex:IM-28561-49	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_001186930.1|refseq:NP_077719.2|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042060"(wound healing)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045967"(negative regulation of growth rate)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0046849"(bone remodeling)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0061073"(ciliary body morphogenesis)|go:"GO:0061314"(Notch signaling involved in heart development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070986"(left/right axis specification)|go:"GO:0072014"(proximal tubule development)|go:"GO:0072015"(glomerular visceral epithelial cell development)|go:"GO:0072104"(glomerular capillary formation)|go:"GO:0072574"(hepatocyte proliferation)|go:"GO:1990705"(cholangiocyte proliferation)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|go:"GO:2001204"(regulation of osteoclast development)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000800(Notch region)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002110(Ankyrin)|interpro:IPR008297(Notch)|interpro:IPR009030(Growth factor, receptor)|go:"GO:0035622"(intrahepatic bile duct development)|interpro:IPR011656(Notch, NODP region)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR018097|interpro:IPR020683|interpro:IPR022336|interpro:IPR010660(Notch, NOD region)|interpro:IPR024600|interpro:IPR035993|interpro:IPR036770|mint:Q04721|rcsb pdb:2OO4|rcsb pdb:5MWB|reactome:R-HSA-1912399|reactome:R-HSA-1912408|reactome:R-HSA-1912420|reactome:R-HSA-2197563|reactome:R-HSA-2979096|reactome:R-HSA-350054|reactome:R-HSA-5083630|reactome:R-HSA-9013695|ensembl:ENSG00000134250(gene)|ensembl:ENST00000256646(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001709"(cell fate determination)|go:"GO:0001947"(heart looping)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0002315"(marginal zone B cell differentiation)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0003162"(atrioventricular node development)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006915"(apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007399"(nervous system development)|go:"GO:0007411"(axon guidance)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009986"(cell surface)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010838"(positive regulation of keratinocyte proliferation)|go:"GO:0016020"(membrane)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019899"(enzyme binding)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0035264"(multicellular organism growth)	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:aXdQSGMwNJ7K0tA2kc3rRFysbIc9606	rigid:pJI4YdgTNDjMd8z2efuk/MWLuCw	false	sufficient binding region:791-1222	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q04721	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-2652733|uniprotkb:Q5T3X7|uniprotkb:Q99734|uniprotkb:Q9H240|ensembl:ENSP00000256646	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:notc2_human(display_long)|uniprotkb:NOTCH2(gene name)|psi-mi:NOTCH2(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514606|imex:IM-28561-1387	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_001186930.1|refseq:NP_077719.2|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042060"(wound healing)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045967"(negative regulation of growth rate)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0046849"(bone remodeling)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0061073"(ciliary body morphogenesis)|go:"GO:0061314"(Notch signaling involved in heart development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070986"(left/right axis specification)|go:"GO:0072014"(proximal tubule development)|go:"GO:0072015"(glomerular visceral epithelial cell development)|go:"GO:0072104"(glomerular capillary formation)|go:"GO:0072574"(hepatocyte proliferation)|go:"GO:1990705"(cholangiocyte proliferation)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|go:"GO:2001204"(regulation of osteoclast development)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000800(Notch region)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002110(Ankyrin)|interpro:IPR008297(Notch)|interpro:IPR009030(Growth factor, receptor)|go:"GO:0035622"(intrahepatic bile duct development)|interpro:IPR011656(Notch, NODP region)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR018097|interpro:IPR020683|interpro:IPR022336|interpro:IPR010660(Notch, NOD region)|interpro:IPR024600|interpro:IPR035993|interpro:IPR036770|mint:Q04721|rcsb pdb:2OO4|rcsb pdb:5MWB|reactome:R-HSA-1912399|reactome:R-HSA-1912408|reactome:R-HSA-1912420|reactome:R-HSA-2197563|reactome:R-HSA-2979096|reactome:R-HSA-350054|reactome:R-HSA-5083630|reactome:R-HSA-9013695|ensembl:ENSG00000134250(gene)|ensembl:ENST00000256646(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001709"(cell fate determination)|go:"GO:0001947"(heart looping)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0002315"(marginal zone B cell differentiation)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0003162"(atrioventricular node development)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006915"(apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007399"(nervous system development)|go:"GO:0007411"(axon guidance)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009986"(cell surface)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010838"(positive regulation of keratinocyte proliferation)|go:"GO:0016020"(membrane)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019899"(enzyme binding)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0035264"(multicellular organism growth)	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:aXdQSGMwNJ7K0tA2kc3rRFysbIc9606	rigid:pJI4YdgTNDjMd8z2efuk/MWLuCw	false	sufficient binding region:791-1222	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q9ULV0	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-311356|uniprotkb:B0I1R3|uniprotkb:Q0P656|uniprotkb:Q9H6Y6|intact:EBI-28979562|ensembl:ENSP00000285039	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:myo5b_human(display_long)|uniprotkb:MYO5B(gene name)|psi-mi:MYO5B(display_short)|uniprotkb:KIAA1119(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514543|imex:IM-28561-837	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	ensembl:ENSP00000285039|ensembl:ENST00000592688|ensembl:ENSP00000466368|ensembl:ENSG00000167306(gene)|ensembl:ENST00000285039(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0003091"(renal water homeostasis)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007015"(actin filament organization)|go:"GO:0015031"(protein transport)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0016459"(myosin complex)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031982"(vesicle)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045179"(apical cortex)|go:"GO:0051015"(actin filament binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR002710(Dilute)|interpro:IPR004009(Myosin, N-terminal, SH3-like)|interpro:IPR027417|interpro:IPR036103|interpro:IPR036961|interpro:IPR037990|mint:Q9ULV0|rcsb pdb:4J5M|rcsb pdb:4LNZ|rcsb pdb:4LWZ|rcsb pdb:4LX0|reactome:R-HSA-432040|refseq:NP_001073936.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:p6fM9FBgui27LRlshWAjPe47Ftc9606	rigid:oocqIMIHRWbf9RhINRYNlYd4Wek	false	sufficient binding region:1219-1731	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q6P1K1	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-1222191|uniprotkb:Q9BUB3|uniprotkb:Q9NX17|ensembl:ENSP00000415998	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:hrg1_human(display_long)|uniprotkb:SLC48A1(gene name)|psi-mi:SLC48A1(display_short)|uniprotkb:Heme-responsive gene 1 protein homolog(gene name synonym)|uniprotkb:HRG1(gene name synonym)|uniprotkb:Solute carrier family 48 member 1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514912|imex:IM-28561-257	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_060312.2|refseq:XP_016875106.1|refseq:XP_016875101.1|refseq:XP_016875103.1|ensembl:ENSG00000211584(gene)|ensembl:ENST00000442218(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0015232"(heme transmembrane transporter activity)|go:"GO:0015886"(heme transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020037"(heme binding)|interpro:IPR026218|mint:Q6P1K1|refseq:XP_016875102.1|refseq:XP_016875104.1|refseq:XP_016875105.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:8mfLinVt8eczyC4sM/2ur/r5Pd89606	rigid:Cn3FFroWIvDHdedimNkIMtbdHHU	false	sufficient binding region:374-740	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q8IXJ6	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-477232|uniprotkb:O95889|uniprotkb:Q924Y7|uniprotkb:Q9P0G8|uniprotkb:Q9UNT0|uniprotkb:Q9Y6E9|ensembl:ENSP00000249396|ensembl:ENSP00000489602|uniprotkb:A8K3V1|uniprotkb:B2RB45|uniprotkb:U5TP13	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:sir2_human(display_long)|uniprotkb:SIR2-like protein 2(gene name synonym)|uniprotkb:SIRT2(gene name)|psi-mi:SIRT2(display_short)|uniprotkb:SIR2L(gene name synonym)|uniprotkb:SIR2L2(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 2(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514903|imex:IM-28561-473	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	ensembl:ENSG00000068903(gene)|ensembl:ENSG00000283100(gene)|ensembl:ENST00000249396(transcript)|ensembl:ENST00000634533(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000183"(rDNA heterochromatin assembly)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000792"(heterochromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0006342"|go:"GO:0006348"|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006914"(autophagy)|go:"GO:0007084"(mitotic nuclear membrane reassembly)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0008134"(transcription factor binding)|rcsb pdb:6L66|rcsb pdb:6L71|rcsb pdb:6L72|rcsb pdb:6NR0|rcsb pdb:6QCN|rcsb pdb:7BOS|rcsb pdb:7BOT|reactome:R-HSA-2995383|rcsb pdb:5D7O|rcsb pdb:5D7P|rcsb pdb:5D7Q|rcsb pdb:5DY4|rcsb pdb:5DY5|rcsb pdb:5FYQ|rcsb pdb:5G4C|rcsb pdb:5MAR|rcsb pdb:5MAT|rcsb pdb:5Y0Z|rcsb pdb:5Y5N|rcsb pdb:5YQL|rcsb pdb:5YQM|rcsb pdb:5YQN|rcsb pdb:5YQO|rcsb pdb:6L65|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016575"(histone deacetylation)|go:"GO:0017136"(NAD-dependent histone deacetylase activity)|go:"GO:0021762"(substantia nigra development)|go:"GO:0022011"(myelination in peripheral nervous system)|go:"GO:0030426"(growth cone)|go:"GO:0030496"(midbody)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033010"(paranodal junction)|go:"GO:0033270"(paranode region of axon)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034979"(NAD-dependent protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042903"(tubulin deacetylase activity)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043204"(perikaryon)|go:"GO:0043209"(myelin sheath)|go:"GO:0043219"(lateral loop)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044242"(cellular lipid catabolic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045836"(positive regulation of meiotic nuclear division)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046970"("NAD-dependent histone deacetylase activity (H4-K16 specific)")|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051775"(response to redox state)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051987"(positive regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0061428"(negative regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061433"(cellular response to caloric restriction)|go:"GO:0070403"(NAD+ binding)|go:"GO:0070446"(negative regulation of oligodendrocyte progenitor proliferation)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0072686"(mitotic spindle)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090042"(tubulin deacetylation)|go:"GO:0097386"(glial cell projection)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|go:"GO:1900195"(positive regulation of oocyte maturation)|go:"GO:1900425"(negative regulation of defense response to bacterium)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000777"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR017328(NAD-dependent deacetylase sirtuin-2, eukaryota)|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|mint:Q8IXJ6|rcsb pdb:1J8F|rcsb pdb:3ZGO|rcsb pdb:3ZGV|rcsb pdb:4L3O|rcsb pdb:4R8M|rcsb pdb:4RMG|rcsb pdb:4RMH|rcsb pdb:4RMI|rcsb pdb:4RMJ|rcsb pdb:4X3O|rcsb pdb:4X3P|rcsb pdb:4Y6L|rcsb pdb:4Y6O|go:"GO:0051301"(cell division)|rcsb pdb:4Y6Q|refseq:NP_001180215.1|refseq:NP_036369.2|refseq:NP_085096.1|refseq:XP_011524956.1|refseq:XP_011524957.1|refseq:XP_006723174.1|dip:DIP-33350N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:d4mOZOyT5RubJjE+a8wQhsWR6WI9606	rigid:HfFI/LwPXYij5Dl8Foy2md5B1P0	false	sufficient binding region:374-740	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q96FS4	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-1054981|uniprotkb:O14518|uniprotkb:O60484|uniprotkb:O60618|uniprotkb:Q2YD83|ensembl:ENSP00000377771|ensembl:ENSP00000436269	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:sipa1_human(display_long)|uniprotkb:GTPase-activating protein Spa-1(gene name synonym)|uniprotkb:p130 SPA-1(gene name synonym)|uniprotkb:SIPA1(gene name)|psi-mi:SIPA1(display_short)|uniprotkb:SPA1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514894|imex:IM-28561-923	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_006738.3|refseq:NP_694985.29|refseq:XP_011543516.1|refseq:XP_005274246.1|ensembl:ENSP00000377771|ensembl:ENSP00000436269|ensembl:ENST00000394224(transcript)|ensembl:ENST00000534313(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007010"(cytoskeleton organization)|ensembl:ENSG00000213445(gene)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016020"(membrane)|go:"GO:0030133"(transport vesicle)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042631"(cellular response to water deprivation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR000331(Rap/ran-GAP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR035974|interpro:IPR036034|mint:Q96FS4|reactome:R-HSA-392517	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:N5g/PMrgPEjYn5Cqv5uo0cAMPJI9606	rigid:szDw10/lPK64vuScS3OmeX1Ah0c	false	sufficient binding region:374-740	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q9H0F6	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-3942966|uniprotkb:D3DWL3|uniprotkb:Q8IXF5|uniprotkb:Q8IXF6|uniprotkb:A6NEG3|uniprotkb:Q8TB25|uniprotkb:Q9BUE4|uniprotkb:Q8N2E7|uniprotkb:C0L3L2|ensembl:ENSP00000381698	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:shrpn_human(display_long)|uniprotkb:SHARPIN(gene name)|psi-mi:SHARPIN(display_short)|uniprotkb:SIPL1(gene name synonym)|uniprotkb:Shank-associated RH domain-interacting protein(gene name synonym)|uniprotkb:Shank-interacting protein-like 1(gene name synonym)|uniprotkb:PSEC0216(orf name)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514885|imex:IM-28561-471	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	ensembl:ENSG00000179526(gene)|ensembl:ENST00000398712(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005829"(cytosol)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007420"(brain development)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030262"(apoptotic nuclear changes)|go:"GO:0030425"(dendrite)|go:"GO:0031424"(keratinization)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0071797"(LUBAC complex)|go:"GO:0097039"(protein linear polyubiquitination)|go:"GO:2000348"(regulation of CD40 signaling pathway)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR026261|reactome:R-HSA-6794361|interpro:IPR029071|interpro:IPR031912|interpro:IPR036443|mint:Q9H0F6|rcsb pdb:4EMO|rcsb pdb:5X0W|reactome:R-HSA-5357905|reactome:R-HSA-5357956|refseq:NP_112236.3|refseq:XP_016869377.1|dip:DIP-57842N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:+RGl3JO1zsGCdaInDn20yhNZs0E9606	rigid:7K+epe51z0bz+rugU1fz57r+mU0	false	sufficient binding region:1219-1731	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q9Y566	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-3442234|uniprotkb:B7WNY6|uniprotkb:Q9NYW9|uniprotkb:A8MXP5|ensembl:ENSP00000293441	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:shan1_human(display_long)|uniprotkb:SHANK1(gene name)|psi-mi:SHANK1(display_short)|uniprotkb:Somatostatin receptor-interacting protein(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514876|imex:IM-28561-59	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:XP_011525316.1|refseq:XP_006723296.1|refseq:NP_057232.2|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007616"(long-term memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008306"(associative learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030160"(synaptic receptor adaptor activity)|ensembl:ENSG00000161681(gene)|go:"GO:0030425"(dendrite)|go:"GO:0030534"(adult behavior)|ensembl:ENST00000293441(transcript)|go:"GO:0031877"(somatostatin receptor binding)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042048"(olfactory behavior)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046959"(habituation)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0050894"(determination of affect)|go:"GO:0060013"(righting reflex)|go:"GO:0060074"(synapse maturation)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071532"(ankyrin repeat binding)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q9Y566|rcsb pdb:6CPI|rcsb pdb:6YWZ|rcsb pdb:6YX0|rcsb pdb:6YX1|rcsb pdb:6YX2|reactome:R-HSA-6794361|ensembl:ENSP00000293441|ensembl:ENST00000359082|ensembl:ENSP00000351984|dip:DIP-40834N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:XhX+mw+sujJRnA6RoKA1QeVywBY9606	rigid:SeIKtH1Rum6DKQzxG2ze1+mTsjg	false	sufficient binding region:1219-1731	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q99963	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-473910|uniprotkb:O43553|uniprotkb:O43554|ensembl:ENSP00000391372	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:sh3g3_human(display_long)|uniprotkb:Endophilin-3(gene name synonym)|uniprotkb:SH3 domain-containing GRB2-like protein 3(gene name synonym)|uniprotkb:SH3 domain protein 2C(gene name synonym)|uniprotkb:EEN-B2(gene name synonym)|uniprotkb:SH3GL3(gene name)|psi-mi:SH3GL3(display_short)|uniprotkb:CNSA3(gene name synonym)|uniprotkb:SH3D2C(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514867|imex:IM-28561-57	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_001288037.1|refseq:NP_001288038.1|ensembl:ENSG00000140600(gene)|ensembl:ENST00000427482(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0006897"(endocytosis)|rcsb pdb:2Z0V|reactome:R-HSA-182971|reactome:R-HSA-6807004|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-9031628|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008289"(lipid binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0098793"(presynapse)|go:"GO:0098845"(postsynaptic endosome)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0031901"(early endosome membrane)|go:"GO:1900186"(negative regulation of clathrin-dependent endocytosis)|interpro:IPR001452(Src homology-3)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR028501|interpro:IPR032469|interpro:IPR035824|interpro:IPR036028|mint:Q99963|rcsb pdb:2EW3|refseq:NP_003018.3|refseq:XP_011520191.1|refseq:NP_001311112.1|refseq:NP_001311114.1|refseq:NP_001311116.1|refseq:XP_016877975.1|dip:DIP-34766N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:0MBJt+lIGr7wul+tAItvkg4LqIQ9606	rigid:BkRc5rMsVHDGXVFJ+iPthd78HhQ	false	sufficient binding region:1219-1731	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q99962	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-77938|ensembl:ENSP00000369981|uniprotkb:Q9NQK5|uniprotkb:B2R618	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:sh3g2_human(display_long)|uniprotkb:SH3GL2(gene name)|psi-mi:SH3GL2(display_short)|uniprotkb:CNSA2(gene name synonym)|uniprotkb:SH3D2A(gene name synonym)|uniprotkb:Endophilin-1(gene name synonym)|uniprotkb:SH3 domain-containing GRB2-like protein 2(gene name synonym)|uniprotkb:SH3 domain protein 2A(gene name synonym)|uniprotkb:EEN-B1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514858|imex:IM-28561-1625	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	go:"GO:0097749"(membrane tubulation)|go:"GO:0097753"(membrane bending)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099050"(vesicle scission)|go:"GO:1903527"(positive regulation of membrane tubulation)|go:"GO:1905604"(negative regulation of blood-brain barrier permeability)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:2000369"(regulation of clathrin-dependent endocytosis)|interpro:IPR001452(Src homology-3)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR035824|interpro:IPR036028|mint:Q99962|rcsb pdb:1X03|rcsb pdb:1X04|rcsb pdb:2D4C|rcsb pdb:2DBM|reactome:R-HSA-177504|reactome:R-HSA-182971|reactome:R-HSA-2132295|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-437239|reactome:R-HSA-6807004|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|ensembl:ENSG00000107295(gene)|ensembl:ENST00000380607(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008289"(lipid binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031175"(neuron projection development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0060988"(lipid tube assembly)|go:"GO:0097441"(basal dendrite)|go:"GO:0097484"(dendrite extension)|refseq:NP_003017.1|dip:DIP-30996N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:mAk7M0s5Dd2Qoa/e1rPYvVcV3xs9606	rigid:bjg08ywZjNK7GUQTTQoMLyYu0NM	false	sufficient binding region:1219-1731	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q13242	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-2949710|ensembl:ENSP00000229390|uniprotkb:Q52LD1	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:srsf9_human(display_long)|uniprotkb:SRSF9(gene name)|psi-mi:SRSF9(display_short)|uniprotkb:SFRS9(gene name synonym)|uniprotkb:SRP30C(gene name synonym)|uniprotkb:Pre-mRNA-splicing factor SRp30C(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 9(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514849|imex:IM-28561-255	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	go:"GO:0006397"(mRNA processing)|go:"GO:0009636"(response to toxic substance)|go:"GO:0016607"(nuclear speck)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0043279"(response to alkaloid)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0006376"(mRNA splice site selection)|interpro:IPR034503|interpro:IPR034995|interpro:IPR035979|mint:Q13242|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72187|reactome:R-HSA-73856|ensembl:ENSG00000111786(gene)|ensembl:ENST00000229390(transcript)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|refseq:NP_003760.1|dip:DIP-40741N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:9x6TWFk1zN1YodjXBiwi/MtNJe49606	rigid:hjKLoobV9gPUbSlgUKGB3VGQhas	false	sufficient binding region:791-1222	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q9BYW2	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-945869|uniprotkb:O75397|uniprotkb:O75405|uniprotkb:Q17RW8|uniprotkb:Q5BKS9|uniprotkb:Q5QGN2|uniprotkb:Q69YI5|uniprotkb:Q6IN64|uniprotkb:Q6ZN53|uniprotkb:Q6ZS25|uniprotkb:Q8N3R0|uniprotkb:Q8TCN0|uniprotkb:Q9C0D1|uniprotkb:Q9H696|uniprotkb:Q9NZW9|ensembl:ENSP00000386759	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:setd2_human(display_long)|uniprotkb:Protein-lysine N-methyltransferase SETD2(gene name synonym)|uniprotkb:KMT3A(gene name synonym)|uniprotkb:SET domain-containing protein 2(gene name synonym)|uniprotkb:Huntingtin-interacting protein B(gene name synonym)|uniprotkb:Huntingtin yeast partner B(gene name synonym)|uniprotkb:Huntingtin-interacting protein 1(gene name synonym)|uniprotkb:HIF-1(gene name synonym)|uniprotkb:p231HBP(gene name synonym)|uniprotkb:Lysine N-methyltransferase 3A(gene name synonym)|uniprotkb:SETD2(gene name)|psi-mi:SETD2(display_short)|uniprotkb:HIF1(gene name synonym)|uniprotkb:HYPB(gene name synonym)|uniprotkb:KIAA1732(gene name synonym)|uniprotkb:SET2(gene name synonym)|uniprotkb:HSPC069(orf name)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514840|imex:IM-28561-919	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_054878.5|ensembl:ENSG00000181555(gene)|ensembl:ENST00000409792(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001763"(morphogenesis of a branching structure)|go:"GO:0001843"(neural tube closure)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006298"(mismatch repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0010569"(regulation of double-strand break repair via homologous recombination)|go:"GO:0010793"(regulation of mRNA export from nucleus)|go:"GO:0016279"(protein-lysine N-methyltransferase activity)|go:"GO:0018023"(peptidyl-lysine trimethylation)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0018026"(peptidyl-lysine monomethylation)|go:"GO:0030900"(forebrain development)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0034340"(response to type I interferon)|go:"GO:0034728"(nucleosome organization)|go:"GO:0035441"(cell migration involved in vasculogenesis)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0046975"("histone methyltransferase activity (H3-K36 specific)")|go:"GO:0048332"(mesoderm morphogenesis)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0048864"(stem cell development)|go:"GO:0051607"(defense response to virus)|go:"GO:0060039"(pericardium development)|go:"GO:0060669"(embryonic placenta morphogenesis)|go:"GO:0060977"(coronary vasculature morphogenesis)|go:"GO:0097198"(histone H3-K36 trimethylation)|go:"GO:0097676"(histone H3-K36 dimethylation)|go:"GO:1902850"(microtubule cytoskeleton organization involved in mitosis)|go:"GO:1905634"(regulation of protein localization to chromatin)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001214(SET)|interpro:IPR003616(Post-SET zinc-binding region)|interpro:IPR006560(AWS)|interpro:IPR013257(SRI, Set2 Rpb1 interacting)|interpro:IPR035441|interpro:IPR036020|interpro:IPR038190|interpro:IPR042294|interpro:IPR044437|mint:Q9BYW2|rcsb pdb:2A7O|rcsb pdb:2MDC|rcsb pdb:2MDI|rcsb pdb:2MDJ|rcsb pdb:4FMU|rcsb pdb:4H12|rcsb pdb:5JJY|rcsb pdb:5JLB|rcsb pdb:5JLE|rcsb pdb:5LSS|rcsb pdb:5LSX|rcsb pdb:5LSY|rcsb pdb:5LSZ|rcsb pdb:5LT6|rcsb pdb:5LT7|rcsb pdb:5LT8|rcsb pdb:5V21|rcsb pdb:5V22|rcsb pdb:6J9J|rcsb pdb:6VDB|reactome:R-HSA-3214841	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:9f0NjyLj+lCSDh5yRP9lVMMepuw9606	rigid:RS7+bUpdiFkMxo+q1Z7ENkyDVzk	false	sufficient binding region:791-1222	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q8IZE3	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-1380680|uniprotkb:Q5THA6|uniprotkb:Q5THA8|uniprotkb:Q8IZN9|uniprotkb:Q96C56|uniprotkb:Q9UBK6|uniprotkb:A8K8Z2|ensembl:ENSP00000356744|ensembl:ENSP00000356746	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:pace1_human(display_long)|uniprotkb:SCYL3(gene name)|psi-mi:SCYL3(display_short)|uniprotkb:PACE1(gene name synonym)|uniprotkb:Ezrin-binding protein PACE-1(gene name synonym)|uniprotkb:SCY1-like protein 3(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514831|imex:IM-28561-1393	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:XP_006711528.1|refseq:NP_065156.5|refseq:NP_851607.2|refseq:XP_016857351.1|refseq:XP_016857352.1|refseq:XP_011508103.1|ensembl:ENSG00000000457(gene)|ensembl:ENST00000367770(transcript)|ensembl:ENST00000367772(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0016477"(cell migration)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042802"(identical protein binding)|go:"GO:0048666"(neuron development)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|mint:Q8IZE3|go:"GO:0030027"(lamellipodium)	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:dWI+Z/AFv8vk3AWqAxXgdHAQVFQ9606	rigid:FnPTmC0shDApAIvMG2QL/gFRzbs	false	sufficient binding region:791-1222	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q59EK9	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-747225|uniprotkb:B2R974|uniprotkb:O15483|uniprotkb:Q7Z3S2|uniprotkb:Q9UF50|intact:EBI-949746|uniprotkb:O60651|ensembl:ENSP00000410862	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:run3a_human(display_long)|uniprotkb:RUNDC3A(gene name)|psi-mi:RUNDC3A(display_short)|uniprotkb:RAP2IP(gene name synonym)|uniprotkb:RPIP8(gene name synonym)|uniprotkb:Rap2-interacting protein 8(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514822|imex:IM-28561-1391	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_001138297.1|refseq:NP_001138298.1|refseq:NP_006686.1|ensembl:ENSG00000108309(gene)|ensembl:ENST00000426726(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0010753"(positive regulation of cGMP-mediated signaling)|go:"GO:0030695"(GTPase regulator activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR004012(RUN)|interpro:IPR037213|mint:Q59EK9|go:"GO:0007264"(small GTPase mediated signal transduction)	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:Xib1v1Fk/1XzTAtGXmxvhP+LQqE9606	rigid:TWbyq0Pb+j5hgXUlCxr5z1AjroE	false	sufficient binding region:374-740	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:O95197	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-740467|intact:EBI-28977804|ensembl:ENSP00000367050|uniprotkb:Q147U9|uniprotkb:Q496K2|uniprotkb:Q53GN3|uniprotkb:Q59EP0|uniprotkb:Q5UEP2|uniprotkb:Q6T930|uniprotkb:Q7RTM7|uniprotkb:Q7RTM8|uniprotkb:Q7RTN3|uniprotkb:B3KQS2|uniprotkb:B7Z308|intact:EBI-11081390|uniprotkb:B7Z4M0|uniprotkb:F5H774	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:rtn3_human(display_long)|uniprotkb:Neuroendocrine-specific protein-like 2(gene name synonym)|uniprotkb:Neuroendocrine-specific protein-like II(gene name synonym)|uniprotkb:RTN3(gene name)|psi-mi:RTN3(display_short)|uniprotkb:NSPL2(gene name synonym)|uniprotkb:ASYIP(gene name synonym)|uniprotkb:Homolog of ASY protein(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514813|imex:IM-28561-1623	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_001252518.1|refseq:NP_006045.1|refseq:NP_958831.1|refseq:NP_958832.1|refseq:NP_958833.1|ensembl:ENSG00000133318(gene)|ensembl:ENST00000377819(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0045202"(synapse)|go:"GO:0071786"(endoplasmic reticulum tubular network organization)|go:"GO:0071787"(endoplasmic reticulum tubular network formation)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|interpro:IPR003388(Reticulon)|mint:O95197|rcsb pdb:7BRU|reactome:R-HSA-8849932|ensembl:ENSP00000348279|ensembl:ENSP00000367050|ensembl:ENST00000537981|ensembl:ENSP00000440874|ensembl:ENST00000540798|ensembl:ENSP00000442733|ensembl:ENST00000339997|ensembl:ENSP00000344106|ensembl:ENST00000341307|ensembl:ENSP00000340903|ensembl:ENST00000354497|ensembl:ENSP00000346492|ensembl:ENST00000356000|refseq:NP_001252519.1|refseq:NP_001252520.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:nlwcgOle9rsXe2uha2//mQlB4Do9606	rigid:lu7HPqmYS0kjeTLGp3LLawSx4zA	false	sufficient binding region:374-740	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:P39023	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-1056348|uniprotkb:Q15548|uniprotkb:Q5I0G0|uniprotkb:B2RDV9|ensembl:ENSP00000346001	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:rl3_human(display_long)|uniprotkb:RPL3(gene name)|psi-mi:RPL3(display_short)|uniprotkb:HIV-1 TAR RNA-binding protein B(gene name synonym)|uniprotkb:Large ribosomal subunit protein uL3(gene name synonym)|uniprotkb:OK/SW-cl.32(orf name)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514804|imex:IM-28561-709	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_000958.1|ensembl:ENSG00000100316(gene)|ensembl:ENST00000216146(transcript)|go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0032991"(protein-containing complex)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071353"(cellular response to interleukin-4)|interpro:IPR000597(Ribosomal protein L3)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR019926|mint:P39023|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:j3MVAYfO/bziJBPmH4zCFqFskZ89606	rigid:7KGR0K458cT7k+fozn1eYC3Cn/4	false	sufficient binding region:374-740	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q9HC36	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-1045440|uniprotkb:Q9NVQ5|uniprotkb:Q53GN1|uniprotkb:Q86VC3|uniprotkb:Q96F76|ensembl:ENSP00000306080	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:mrm3_human(display_long)|uniprotkb:MRM3(gene name)|psi-mi:MRM3(display_short)|uniprotkb:"16S rRNA (guanosine(1370)-2'-O)-methyltransferase"(gene name synonym)|uniprotkb:16S rRNA [Gm1370] 2'-O-methyltransferase(gene name synonym)|uniprotkb:RNA methyltransferase-like protein 1(gene name synonym)|uniprotkb:RNMTL1(gene name synonym)|uniprotkb:HC90(orf name)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514795|imex:IM-28561-1619	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_060616.1|refseq:NP_001304876.1|ensembl:ENSG00000171861(gene)|ensembl:ENST00000304478(transcript)|go:"GO:0000451"(rRNA 2'-O-methylation)|go:"GO:0003723"(RNA binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0042802"(identical protein binding)|go:"GO:0070039"("rRNA (guanosine-2'-O-)-methyltransferase activity")|interpro:IPR001537(tRNA/rRNA methyltransferase, SpoU)|interpro:IPR013123(RNA 2-O ribose methyltransferase, substrate binding)|interpro:IPR029028|interpro:IPR029064|mint:Q9HC36|reactome:R-HSA-6793080	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:oOaJQgUM9tpIOv6A20UkLtAQH9c9606	rigid:6H+3AsSNpMFnzcCLUvtEO5t0QK4	false	sufficient binding region:791-1222	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q17R89	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-720416|uniprotkb:Q9Y4Q4|uniprotkb:A8MQB2|uniprotkb:O75160|uniprotkb:Q7Z5Z7|uniprotkb:A6NCP5|ensembl:ENSP00000368994	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:rhg44_human(display_long)|uniprotkb:RhoGAP interacting with CIP4 homologs protein 2(gene name synonym)|uniprotkb:Rho-type GTPase-activating protein RICH2(gene name synonym)|uniprotkb:NPC-A-10(gene name synonym)|uniprotkb:ARHGAP44(gene name)|psi-mi:ARHGAP44(display_short)|uniprotkb:KIAA0672(gene name synonym)|uniprotkb:RICH2(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514786|imex:IM-28561-707	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	mint:Q17R89|refseq:NP_055674.4|ensembl:ENSG00000006740(gene)|ensembl:ENST00000379672(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005829"(cytosol)|go:"GO:0006887"(exocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030425"(dendrite)|go:"GO:0031256"(leading edge membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035021"(negative regulation of Rac protein signal transduction)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051490"(negative regulation of filopodium assembly)|go:"GO:0055037"(recycling endosome)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0098886"(modification of dendritic spine)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099152"(regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR004148(BAR)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR027267|refseq:NP_001308095.1|refseq:NP_001308097.1|reactome:R-HSA-8980692|reactome:R-HSA-9013148|reactome:R-HSA-9013149	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:gN2xiWHjD8x8sIV6o2YJV+/RRSQ9606	rigid:f2l7YePh0A4DIEzgX3XjOvewZdI	false	sufficient binding region:374-740	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:P52756	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-714003|uniprotkb:Q93021|uniprotkb:Q9BU14|uniprotkb:Q9UKY8|uniprotkb:Q9UL24|ensembl:ENSP00000343054|uniprotkb:B2RA45|uniprotkb:B4DM16|uniprotkb:B4DMF9|uniprotkb:B4DZ63|uniprotkb:Q9HDA6|intact:EBI-16431417	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:rbm5_human(display_long)|uniprotkb:RNA-binding motif protein 5(gene name synonym)|uniprotkb:Putative tumor suppressor LUCA15(gene name synonym)|uniprotkb:Protein G15(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-9(gene name synonym)|uniprotkb:RBM5(gene name)|psi-mi:RBM5(display_short)|uniprotkb:H37(orf name)|uniprotkb:LUCA15(orf name)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514777|imex:IM-28561-1135	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	ensembl:ENSG00000003756(gene)|ensembl:ENST00000347869(transcript)|go:"GO:0000245"(spliceosomal complex assembly)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR033094|interpro:IPR034991|interpro:IPR034993|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0006396"(RNA processing)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|interpro:IPR000467(D111/G-patch)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|interpro:IPR036443|interpro:IPR041591|mint:P52756|rcsb pdb:2LK0|rcsb pdb:2LK1|rcsb pdb:2LKZ|rcsb pdb:5MF9|rcsb pdb:5MFY|reactome:R-HSA-72163|refseq:NP_005769.1|refseq:XP_016860992.1|dip:DIP-47277N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:LsPTpaKrGY2xtpYofHbFVXjSi/A9606	rigid:83P0Xcfqf1b7RiYHArKLqeaYQYI	false	sufficient binding region:1219-1731	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:O00391	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-3920904|uniprotkb:Q8TDL6|uniprotkb:Q8WVP4|uniprotkb:Q5T2X0|uniprotkb:Q59G29|ensembl:ENSP00000356574	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:qsox1_human(display_long)|uniprotkb:QSOX1(gene name)|psi-mi:QSOX1(display_short)|uniprotkb:QSCN6(gene name synonym)|uniprotkb:Quiescin Q6(gene name synonym)|uniprotkb:UNQ2520/PRO6013(orf name)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514768|imex:IM-28561-1133	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_001004128.1|refseq:NP_002817.2|ensembl:ENSG00000116260(gene)|ensembl:ENST00000367602(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006457"(protein folding)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016971"(flavin-linked sulfhydryl oxidase activity)|go:"GO:0030173"(integral component of Golgi membrane)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0035580"(specific granule lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045171"(intercellular bridge)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071949"(FAD binding)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR017905|interpro:IPR036249|interpro:IPR036774|interpro:IPR039798|interpro:IPR040986|interpro:IPR041269|interpro:IPR042568|mint:O00391|rcsb pdb:3LLI|rcsb pdb:3LLK|rcsb pdb:3Q6O|rcsb pdb:4IJ3|reactome:R-HSA-114608|reactome:R-HSA-381426|reactome:R-HSA-6798695|reactome:R-HSA-8957275	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:F7LxFmHYOzyu51/r0FQHYzQeUbU9606	rigid:0QfxObq1XODwbmqMHp/qk/gU4fU	false	sufficient binding region:791-1222	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:O60299	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-6381598|ensembl:ENSP00000332123|ensembl:ENSP00000338166|uniprotkb:A2A2Q7|uniprotkb:D3DVX6|uniprotkb:Q8IXX8	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:lzts3_human(display_long)|uniprotkb:LZTS3(gene name)|psi-mi:LZTS3(display_short)|uniprotkb:KIAA0552(gene name synonym)|uniprotkb:PROSAPIP1(gene name synonym)|uniprotkb:ProSAP-interacting protein 1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514750|imex:IM-28561-917	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_001269462.1|ensembl:ENSG00000088899(gene)|ensembl:ENST00000329152(transcript)|ensembl:ENST00000337576(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0014069"(postsynaptic density)|go:"GO:0043197"(dendritic spine)|go:"GO:0045202"(synapse)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|interpro:IPR033295|mint:O60299|refseq:XP_005260949.1|refseq:XP_005260950.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:MqczwNycBAI9kLRMvgOpmXrJpLo9606	rigid:w6Tx4WcKhgByg0Eml+V6OvpHBHE	false	sufficient binding region:374-740	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:P55345	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-78458|uniprotkb:P78350|uniprotkb:Q9BW15|uniprotkb:Q9UMC2|ensembl:ENSP00000347906|ensembl:ENSP00000380759|ensembl:ENSP00000380760|uniprotkb:Q6FHF0|uniprotkb:Q99781|uniprotkb:Q498Y5|uniprotkb:B7U630|uniprotkb:B7U631|uniprotkb:B7U632|uniprotkb:Q5U7D4	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:anm2_human(display_long)|uniprotkb:PRMT2(gene name)|psi-mi:PRMT2(display_short)|uniprotkb:HMT1(gene name synonym)|uniprotkb:Histone-arginine N-methyltransferase PRMT2(gene name synonym)|uniprotkb:HRMT1L1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514741|imex:IM-28561-469	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	ensembl:ENSG00000160310(gene)|ensembl:ENST00000355680(transcript)|ensembl:ENST00000397637(transcript)|ensembl:ENST00000397638(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006479"(protein methylation)|go:"GO:0007165"(signal transduction)|go:"GO:0008469"(histone-arginine N-methyltransferase activity)|go:"GO:0016274"(protein-arginine N-methyltransferase activity)|go:"GO:0016571"(histone methylation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0033142"(progesterone receptor binding)|go:"GO:0035242"(protein-arginine omega-N asymmetric methyltransferase activity)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0042975"(peroxisome proliferator activated receptor binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046966"(thyroid hormone receptor binding)|go:"GO:0048588"(developmental cell growth)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0060765"(regulation of androgen receptor signaling pathway)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001452(Src homology-3)|interpro:IPR007848(Methyltransferase small)|interpro:IPR025799|interpro:IPR029063|interpro:IPR036028|mint:P55345|rcsb pdb:1X2P|refseq:NP_001526.2|refseq:NP_996845.1|refseq:NP_001273605.1|refseq:NP_001273606.1|refseq:NP_001273607.1|refseq:NP_001229794.1|refseq:NP_001229793.1|refseq:XP_005261168.1|refseq:NP_001229795.1|refseq:XP_006724061.1|refseq:XP_006724063.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:+xna8Cy+5sQWV6hvKfg4rNrQKBw9606	rigid:gd1iKeBUsdif273OY2yeH2K3DKk	false	sufficient binding region:791-1222	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q9Y5P8	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-2479826|intact:EBI-28984956|ensembl:ENSP00000375080|uniprotkb:Q6P4G9|uniprotkb:Q7RTT1|uniprotkb:Q96H01	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:p2r3b_human(display_long)|uniprotkb:PPP2R3B(gene name)|psi-mi:PPP2R3B(display_short)|uniprotkb:PPP2R3L(gene name synonym)|uniprotkb:Protein phosphatase 2A 48 kDa regulatory subunit(gene name synonym)|uniprotkb:PP2A subunit B isoform PR48(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514732|imex:IM-28561-915	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	ensembl:ENSG00000167393(gene)|ensembl:ENST00000390665(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR041534|mint:Q9Y5P8|rcsb pdb:4I5L|rcsb pdb:4I5N|rcsb pdb:4MEW|reactome:R-HSA-113501|reactome:R-HSA-69231|reactome:R-HSA-69273|go:"GO:0005654"(nucleoplasm)|refseq:NP_037371.2|ensembl:ENSP00000375080	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:zl5NREjuW2ahdojQSDcqWYJR92g9606	rigid:Cn4a7wSUxVVCc7KFK4AGWplcM7E	false	sufficient binding region:1219-1731	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q96SB3	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-351275|uniprotkb:Q8TCR9|intact:EBI-28984643|ensembl:ENSP00000478767|intact:EBI-4401886|uniprotkb:D3DTX6	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:neb2_human(display_long)|uniprotkb:Neurabin-II(gene name synonym)|uniprotkb:Spinophilin(gene name synonym)|uniprotkb:Protein phosphatase 1 regulatory subunit 9B(gene name synonym)|uniprotkb:PPP1R9B(gene name)|psi-mi:PPP1R9B(display_short)|uniprotkb:PPP1R6(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514723|imex:IM-28561-1131	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	ensembl:ENSG00000108819(gene)|ensembl:ENST00000612501(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0001560"(regulation of cell growth by extracellular stimulus)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001975"(response to amphetamine)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004864"(protein phosphatase inhibitor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007015"(actin filament organization)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0007568"(aging)|go:"GO:0007612"(learning)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016358"(dendrite development)|go:"GO:0016477"(cell migration)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019900"(kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0030175"(filopodium)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031175"(neuron projection development)|go:"GO:0031749"(D2 dopamine receptor binding)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032587"(ruffle membrane)|go:"GO:0034695"(response to prostaglandin E)|go:"GO:0035094"(response to nicotine)|go:"GO:0035690"|go:"GO:0035902"(response to immobilization stress)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0046847"(filopodium assembly)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051015"(actin filament binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060179"(male mating behavior)|go:"GO:0061458"(reproductive system development)|go:"GO:0071315"(cellular response to morphine)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0097338"(response to clozapine)|go:"GO:1901653"(cellular response to peptide)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903119"(protein localization to actin cytoskeleton)|go:"GO:1904372"(positive regulation of protein localization to actin cortical patch)|go:"GO:1904373"(response to kainic acid)|go:"GO:1904386"(response to L-phenylalanine derivative)|go:"GO:1990778"(protein localization to cell periphery)|go:"GO:1990780"(cytoplasmic side of dendritic spine plasma membrane)|go:"GO:2000474"(regulation of opioid receptor signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR029921|interpro:IPR036034|interpro:IPR040645|interpro:IPR043446|mint:Q96SB3|ensembl:ENSP00000478767|refseq:NP_115984.3	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:X6fQLpaYhXCqzRlQNEoX67P/HbU9606	rigid:/bgPc4+2An8acDBWBKtRLxNj7FE	false	sufficient binding region:1219-1731	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q8WUF5	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-5550163|uniprotkb:Q2PNZ9|uniprotkb:Q5DU71|uniprotkb:Q5I1X4|uniprotkb:Q6P1R7|uniprotkb:Q6PKF8|uniprotkb:Q9Y290|ensembl:ENSP00000354218|ensembl:ENSP00000403902	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:iaspp_human(display_long)|uniprotkb:PPP1R13L(gene name)|psi-mi:PPP1R13L(display_short)|uniprotkb:IASPP(gene name synonym)|uniprotkb:NKIP1(gene name synonym)|uniprotkb:PPP1R13BL(gene name synonym)|uniprotkb:RAI(gene name synonym)|uniprotkb:Inhibitor of ASPP protein(gene name synonym)|uniprotkb:NFkB-interacting protein 1(gene name synonym)|uniprotkb:PPP1R13B-like protein(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514714|imex:IM-28561-705	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_001135974.1|refseq:NP_006654.2|refseq:XP_016881666.1|refseq:XP_016881667.1|dip:DIP-29586N|ensembl:ENSG00000104881(gene)|ensembl:ENST00000360957(transcript)|ensembl:ENST00000418234(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|go:"GO:0003229"(ventricular cardiac muscle tissue development)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0030054"(cell junction)|go:"GO:0031076"(embryonic camera-type eye development)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042633"(hair cycle)|go:"GO:0042802"(identical protein binding)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045296"(cadherin binding)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0060048"(cardiac muscle contraction)|interpro:IPR001452(Src homology-3)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR028320|interpro:IPR036028|interpro:IPR036770|interpro:IPR042722|mint:Q8WUF5|rcsb pdb:2VGE|rcsb pdb:6DCX|rcsb pdb:6HL6|rcsb pdb:6RZ3|reactome:R-HSA-6804759	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:0MfBf9sG2+pc4Isd+GDCBm6b9Eo9606	rigid:Hu4y3CzjCZo4Kl8124RA/FE93nY	false	sufficient binding region:374-740	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q8NEY8	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-474076|uniprotkb:Q86YT2|uniprotkb:Q8IXN3|uniprotkb:Q8TB09|uniprotkb:Q96NB9|uniprotkb:Q9NXL4|uniprotkb:Q9P0P6|uniprotkb:Q9P0R9|uniprotkb:E9PAX8|ensembl:ENSP00000378935|ensembl:ENSP00000479913	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:pphln_human(display_long)|uniprotkb:Gastric cancer antigen Ga50(gene name synonym)|uniprotkb:HSPC206(orf name)|uniprotkb:HSPC232(orf name)|uniprotkb:PPHLN1(gene name)|psi-mi:PPHLN1(display_short)|uniprotkb:CDC7 expression repressor(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514705|imex:IM-28561-53	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_001137259.1|refseq:NP_001137260.1|refseq:NP_057572.5|refseq:NP_958846.1|refseq:NP_958847.1|refseq:NP_958848.1|refseq:NP_958923.1|dip:DIP-49051N|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0031424"(keratinization)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0090309"(positive regulation of DNA methylation-dependent heterochromatin assembly)|go:"GO:0097355"(protein localization to heterochromatin)|interpro:IPR028851|mint:Q8NEY8|rcsb pdb:6SWG|ensembl:ENSG00000134283(gene)|ensembl:ENST00000395568(transcript)|ensembl:ENST00000610488(transcript)	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:+s8KstGQ7d91qe3DDnpKYMJon7o9606	rigid:nad1CV3n1fecg5nz7NYM7TAAdx8	false	sufficient binding region:1219-1731	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q9H4M7	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-716549|uniprotkb:Q8N4M8|uniprotkb:Q8N658|ensembl:ENSP00000263265	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:pkha4_human(display_long)|uniprotkb:Phosphoinositol 3-phosphate-binding protein 1(gene name synonym)|uniprotkb:PLEKHA4(gene name)|psi-mi:PLEKHA4(display_short)|uniprotkb:PEPP1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514696|imex:IM-28561-1129	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_001154826.1|refseq:NP_065955.2|ensembl:ENSG00000105559(gene)|ensembl:ENST00000263265(transcript)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:2000096"(positive regulation of Wnt signaling pathway, planar cell polarity pathway)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR040392|rcsb pdb:1UPQ|rcsb pdb:1UPR|reactome:R-HSA-1660499	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:gBeBdIcJIF2fJe6r+Ea2gmiKiTQ9606	rigid:aG9/ZuawXKhM9fu2th8VTruDaEA	false	sufficient binding region:374-740	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q9NRD5	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-79165|uniprotkb:O95906|ensembl:ENSP00000349465|ensembl:ENSP00000385205|intact:EBI-2622151|uniprotkb:B3KS52	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:pick1_human(display_long)|uniprotkb:PICK1(gene name)|psi-mi:PICK1(display_short)|uniprotkb:PRKCABP(gene name synonym)|uniprotkb:Protein kinase C-alpha-binding protein(gene name synonym)|uniprotkb:Protein interacting with C kinase 1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514687|imex:IM-28561-703	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	ensembl:ENSG00000100151(gene)|ensembl:ENST00000356976(transcript)|ensembl:ENST00000404072(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|refseq:NP_001034672.1|refseq:NP_001034673.1|refseq:NP_036539.1|go:"GO:0015844"(monoamine transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021782"(glial cell development)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0034315"(regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0034316"(negative regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0036294"(cellular response to decreased oxygen levels)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0043113"(receptor clustering)|go:"GO:0045161"(neuronal ion channel clustering)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051015"(actin filament binding)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0098842"(postsynaptic early endosome)|go:"GO:0140090"(membrane curvature sensor activity)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR010504(Arfaptin-like)|interpro:IPR027267|interpro:IPR030798|interpro:IPR036034|interpro:IPR037959|mint:Q9NRD5|rcsb pdb:2GZV|rcsb pdb:6AR4|rcsb pdb:6BJN|rcsb pdb:6BJO|reactome:R-HSA-202733|reactome:R-HSA-416993	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:qRx+eNG7We8Oe0SQOekqpJpn8zk9606	rigid:nPvxo/N7fbzdeVK0iUALbP9uxps	false	sufficient binding region:1219-1731	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q86UU1	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-4289858|uniprotkb:Q4KMF8|uniprotkb:Q8TEQ2|uniprotkb:O75133|uniprotkb:B0YJ63|uniprotkb:B0YJ64|intact:EBI-28975144|ensembl:ENSP00000354498|ensembl:ENSP00000469820	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:phlb1_human(display_long)|uniprotkb:PHLDB1(gene name)|psi-mi:PHLDB1(display_short)|uniprotkb:KIAA0638(gene name synonym)|uniprotkb:LL5A(gene name synonym)|uniprotkb:Protein LL5-alpha(gene name synonym)|uniprotkb:DLNB07(orf name)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514678|imex:IM-28561-1389	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	ensembl:ENST00000356063|ensembl:ENSP00000348359|ensembl:ENSP00000354498|ensembl:ENST00000528594|ensembl:ENSP00000435520|ensembl:ENST00000530994|ensembl:ENSP00000431508|ensembl:ENSP00000469820|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR037810|mint:Q86UU1|ensembl:ENSG00000019144(gene)|ensembl:ENST00000361417(transcript)|ensembl:ENST00000600882(transcript)|go:"GO:0010470"(regulation of gastrulation)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0045180"(basal cortex)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:1904261"(positive regulation of basement membrane assembly involved in embryonic body morphogenesis)|interpro:IPR000253(Forkhead-associated)|interpro:IPR001849(Pleckstrin-like)|refseq:NP_001138230.1|refseq:NP_001138231.1|refseq:NP_055972.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:Za4UuXVuMr4gzY2kr8EadOf5hWA9606	rigid:ctTQkcSLknqsFSqTQgnkNAxXUkk	false	sufficient binding region:1219-1731	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q96QT6	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-2803760|uniprotkb:Q9BV34|uniprotkb:Q9P205|uniprotkb:Q6ZML2|uniprotkb:Q0VAI5|uniprotkb:Q9H7U9|ensembl:ENSP00000329933|uniprotkb:Q2TAK2	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:phf12_human(display_long)|uniprotkb:KIAA1523(gene name synonym)|uniprotkb:PHD factor 1(gene name synonym)|uniprotkb:PHF12(gene name)|psi-mi:PHF12(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514669|imex:IM-28561-1617	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_001028733.1|refseq:NP_065940.1|ensembl:ENSG00000109118(gene)|ensembl:ENST00000332830(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016580"(Sin3 complex)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0070822"(Sin3-type complex)|interpro:IPR000253(Forkhead-associated)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR031966|interpro:IPR038098|interpro:IPR042163|mint:Q96QT6|rcsb pdb:2L9S|rcsb pdb:2LKM|refseq:NP_001277060.1|dip:DIP-59632N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:PSctZ9CGOcztlg6VdcB1jkIOhjo9606	rigid:h7nVoK5TT0eWWGHrvkZxNHIwSMI	false	sufficient binding region:374-740	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:P17858	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-487243|uniprotkb:Q96A64|uniprotkb:Q96IH4|uniprotkb:Q9BR91|ensembl:ENSP00000269848	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:pfkal_human(display_long)|uniprotkb:PFKL(gene name)|psi-mi:PFKL(display_short)|uniprotkb:Phosphohexokinase(gene name synonym)|uniprotkb:Phosphofructo-1-kinase isozyme B(gene name synonym)|uniprotkb:6-phosphofructokinase type B(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514660|imex:IM-28561-51	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_001002021.2|refseq:NP_002617.3|go:"GO:0006002"(fructose 6-phosphate metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0009749"(response to glucose)|go:"GO:0016020"(membrane)|go:"GO:0016208"(AMP binding)|go:"GO:0019900"(kinase binding)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0070095"(fructose-6-phosphate binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048029"(monosaccharide binding)|go:"GO:0061621"(canonical glycolysis)|go:"GO:0070061"(fructose binding)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000023(Phosphofructokinase)|interpro:IPR009161(6-phosphofructokinase, eukaryotic type)|interpro:IPR015912(Phosphofructokinase, conserved site)|interpro:IPR022953|interpro:IPR035966|interpro:IPR041914|mint:P17858|reactome:R-HSA-6798695|reactome:R-HSA-70171|ensembl:ENSG00000141959(gene)|ensembl:ENST00000349048(transcript)|go:"GO:0003872"(6-phosphofructokinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005945"(6-phosphofructokinase complex)	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:lP9/V5WcCl5rLpy4QEZnWkLCCcQ9606	rigid:DBVHUzryrUGY27TX5r0/ToTuFO8	false	sufficient binding region:374-740	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:P11177	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-1035872|uniprotkb:B2R7L0|uniprotkb:Q6FH45|uniprotkb:Q9BQ27|uniprotkb:Q9UFK3|ensembl:ENSP00000307241|uniprotkb:B4DDD7	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:odpb_human(display_long)|uniprotkb:PDHB(gene name)|psi-mi:PDHB(display_short)|uniprotkb:PHE1B(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514651|imex:IM-28561-253	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	ensembl:ENSG00000168291(gene)|ensembl:ENST00000302746(transcript)|go:"GO:0004739"("pyruvate dehydrogenase (acetyl-transferring) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005967"(mitochondrial pyruvate dehydrogenase complex)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006086"(acetyl-CoA biosynthetic process from pyruvate)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0045254"(pyruvate dehydrogenase complex)|go:"GO:0061732"(mitochondrial acetyl-CoA biosynthetic process from pyruvate)|interpro:IPR005475(Transketolase, central region)|interpro:IPR009014(Transketolase, C-terminal/Pyruvate-ferredoxin oxidoreductase, domain II)|interpro:IPR027110|interpro:IPR029061|interpro:IPR033248|mint:P11177|rcsb pdb:1NI4|rcsb pdb:2OZL|rcsb pdb:3EXE|rcsb pdb:3EXF|rcsb pdb:3EXG|rcsb pdb:3EXH|rcsb pdb:3EXI|rcsb pdb:6CER|rcsb pdb:6CFO|reactome:R-HSA-204174|reactome:R-HSA-389661|reactome:R-HSA-5362517|reactome:R-HSA-70268|refseq:NP_000916.2|refseq:NP_001166939.1|refseq:NP_001302465.1|dip:DIP-37651N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:VnabVXgFi4b43Wl37PzUX3+j4A89606	rigid:Llu1AWGrRX6IlCQ9WXy+xMzD5fg	false	sufficient binding region:1219-1731	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q96F24	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-2362014|uniprotkb:Q86UR2|uniprotkb:Q96NP6|uniprotkb:Q9H0S9|uniprotkb:Q9H2I2|uniprotkb:A6PW36|uniprotkb:B4DWS0|ensembl:ENSP00000277746	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:nrbf2_human(display_long)|uniprotkb:NRBF2(gene name)|psi-mi:NRBF2(display_short)|uniprotkb:COPR(gene name synonym)|uniprotkb:Comodulator of PPAR and RXR(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514642|imex:IM-28561-1615	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_110386.2|refseq:NP_001269334.1|ensembl:ENSG00000148572(gene)|ensembl:ENST00000277746(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0006914"(autophagy)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0043550"(regulation of lipid kinase activity)|interpro:IPR015056(Protein of unknown function DUF1875)|interpro:IPR033393|interpro:IPR039679|rcsb pdb:4ZEY|reactome:R-HSA-383280	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:PWt0/5LsBllvyqOhdHX0ulbq4mc9606	rigid:WS1wecV4S/j1OOBXA7BZZpz7Kzw	false	sufficient binding region:374-740	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:P20393	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-2811738|uniprotkb:Q15304|uniprotkb:Q0P5Z4|ensembl:ENSP00000246672	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:nr1d1_human(display_long)|uniprotkb:NR1D1(gene name)|psi-mi:NR1D1(display_short)|uniprotkb:EAR1(gene name synonym)|uniprotkb:HREV(gene name synonym)|uniprotkb:THRAL(gene name synonym)|uniprotkb:Rev-erbA-alpha(gene name synonym)|uniprotkb:V-erbA-related protein 1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514633|imex:IM-28561-251	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_068370.1|ensembl:ENSG00000126368(gene)|ensembl:ENST00000246672(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016604"(nuclear body)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0020037"(heme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031648"(protein destabilization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042749"(regulation of circadian sleep/wake cycle)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043197"(dendritic spine)|go:"GO:0044321"(response to leptin)|go:"GO:0045598"(regulation of fat cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0060086"(circadian temperature homeostasis)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0061469"(regulation of type B pancreatic cell proliferation)|go:"GO:0061889"(negative regulation of astrocyte activation)|go:"GO:0070859"(positive regulation of bile acid biosynthetic process)|go:"GO:0070888"(E-box binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0150079"(negative regulation of neuroinflammatory response)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|rcsb pdb:1A6Y|rcsb pdb:1EF6|rcsb pdb:1GA5|rcsb pdb:1HLZ|rcsb pdb:3N00|reactome:R-HSA-1368071|reactome:R-HSA-1989781|reactome:R-HSA-2151201|reactome:R-HSA-383280|reactome:R-HSA-400253|reactome:R-HSA-9707616|dip:DIP-48396N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:UfaVQzUQ3wD4xDBh1sjp+eaawY89606	rigid:rgyK/ijjALQB0HpQxEmcDyYERAA	false	sufficient binding region:791-1222	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q9UM47	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-1236377|uniprotkb:Q9UEB3|uniprotkb:Q9UPL3|uniprotkb:Q9Y6L8|ensembl:ENSP00000263388	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:notc3_human(display_long)|uniprotkb:NOTCH3(gene name)|psi-mi:NOTCH3(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514624|imex:IM-28561-913	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_000426.2|ensembl:ENSP00000263388|dip:DIP-39827N|ensembl:ENSG00000074181(gene)|ensembl:ENST00000263388(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0009986"(cell surface)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043235"(receptor complex)|go:"GO:0045296"(cadherin binding)|go:"GO:0050793"(regulation of developmental process)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000800(Notch region)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002110(Ankyrin)|interpro:IPR008297(Notch)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR010660(Notch, NOD region)|interpro:IPR011656(Notch, NODP region)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR018097|interpro:IPR020683|interpro:IPR022331|interpro:IPR024600|interpro:IPR035993|interpro:IPR036770|mint:Q9UM47|rcsb pdb:4ZLP|rcsb pdb:5CZV|rcsb pdb:5CZX|rcsb pdb:6WQU|reactome:R-HSA-1912399|reactome:R-HSA-1912408|reactome:R-HSA-1912420|reactome:R-HSA-350054|reactome:R-HSA-5083630|reactome:R-HSA-9013507|reactome:R-HSA-9013508|reactome:R-HSA-9017802	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:hOarWT2DBhNVF6AhV/z+NqLCEv49606	rigid:1NY+MPUNw/cG9g9Axe/sepKhPWk	false	sufficient binding region:791-1222	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q7Z3S9	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-945833|intact:EBI-2859688|uniprotkb:Q5BKT8|uniprotkb:Q5VTG9|uniprotkb:Q5XG84|uniprotkb:Q6P192|uniprotkb:Q8NC23|uniprotkb:Q8WUQ9|uniprotkb:Q96FY1|ensembl:ENSP00000354929	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:nt2na_human(display_long)|uniprotkb:NOTCH2NLA(gene name)|psi-mi:NOTCH2NLA(display_short)|uniprotkb:N2N(gene name synonym)|uniprotkb:NOTCH2NL(gene name synonym)|uniprotkb:Notch homolog 2 N-terminal-like protein(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514615|imex:IM-28561-1613	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_982283.2|refseq:XP_016855384.1|refseq:XP_016855385.1|refseq:XP_016855386.1|refseq:XP_016855387.1|refseq:XP_016858537.1|refseq:XP_016858538.1|refseq:XP_016858539.1|refseq:XP_016858540.1|dip:DIP-47315N|refseq:XP_006711766.1|refseq:XP_006726418.1|ensembl:ENSG00000264343(gene)|ensembl:ENST00000362074(transcript)|go:"GO:0005112"(Notch binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030154"(cell differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR018097|mint:Q7Z3S9	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:FYOai/KkVz8zMsxjNnyZ6FNfcTU9606	rigid:st1xNbNc+OJdJIUCNtrXrbDfq4c	false	sufficient binding region:791-1222	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:P63162	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-712493|ensembl:ENSP00000463458|ensembl:ENSP00000494831|ensembl:ENSP00000495345|ensembl:ENSP00000306223|ensembl:ENSP00000375105|ensembl:ENSP00000382969|ensembl:ENSP00000382972|uniprotkb:P14648|uniprotkb:P17135|uniprotkb:Q0D2Q5|uniprotkb:B3KVR1	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:rsmn_human(display_long)|uniprotkb:Tissue-specific-splicing protein(gene name synonym)|uniprotkb:SNRPN(gene name)|psi-mi:SNRPN(display_short)|uniprotkb:HCERN3(gene name synonym)|uniprotkb:SMN(gene name synonym)|uniprotkb:Sm protein N(gene name synonym)|uniprotkb:Sm protein D(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514921|imex:IM-28561-259	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	ensembl:ENST00000346403(transcript)|ensembl:ENST00000390687(transcript)|ensembl:ENST00000400097(transcript)|ensembl:ENST00000400100(transcript)|ensembl:ENST00000577565(transcript)|ensembl:ENST00000642807(transcript)|ensembl:ENST00000645002(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0005685"(U1 snRNP)|go:"GO:0005686"(U2 snRNP)|go:"GO:0005687"(U4 snRNP)|go:"GO:0005737"(cytoplasm)|go:"GO:0008380"(RNA splicing)|ensembl:ENSG00000128739(gene)|go:"GO:0030532"(small nuclear ribonucleoprotein complex)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071004"(U2-type prespliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR017131(Small ribonucleoprotein associated, SmB/SmN)|mint:P63162|rcsb pdb:5MF9|reactome:R-HSA-72163|go:"GO:0009725"(response to hormone)|refseq:NP_003088.1|refseq:NP_073716.1|refseq:NP_073717.1|refseq:NP_073718.1|refseq:NP_073719.1|refseq:NP_005669.2	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:F839ujOi+/hObAvs2L3Majys3E09606	rigid:jAUI8t4KspS5BjsIUd5J/DgOY4s	false	sufficient binding region:374-740	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:O94875	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-311323|intact:EBI-747334|uniprotkb:B7Z1G5|uniprotkb:C9JKV9|uniprotkb:G3XAI0|intact:EBI-2804177|uniprotkb:A6NEK9|uniprotkb:O60592|uniprotkb:O60593|uniprotkb:Q96EX0|uniprotkb:D3DP62|uniprotkb:D3DP63|intact:EBI-28977791|ensembl:ENSP00000284776|uniprotkb:B7Z3X6|uniprotkb:E9PAS5|uniprotkb:E9PAW4|uniprotkb:B3KPQ7|uniprotkb:H7BXR4|uniprotkb:J3KNZ5|intact:EBI-10983198|intact:EBI-10965282	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:srbs2_human(display_long)|uniprotkb:SORBS2(gene name)|psi-mi:SORBS2(display_short)|uniprotkb:ARGBP2(gene name synonym)|uniprotkb:KIAA0777(gene name synonym)|uniprotkb:Arg/Abl-interacting protein 2(gene name synonym)|uniprotkb:Sorbin(gene name synonym)|uniprotkb:Arg-binding protein 2(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514930|imex:IM-28561-1627	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	ensembl:ENSP00000284776|ensembl:ENST00000319471|ensembl:ENSP00000322182|ensembl:ENST00000355634|ensembl:ENSP00000347852|ensembl:ENST00000393528|ensembl:ENSP00000377162|ensembl:ENST00000418609|ensembl:ENSP00000397482|ensembl:ENST00000437304|ensembl:ENSP00000396008|ensembl:ENST00000448662|ensembl:ENSP00000409158|ensembl:ENST00000449407|ensembl:ENSP00000397262|ensembl:ENSG00000154556(gene)|ensembl:ENST00000284776(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0008093"(cytoskeletal anchor activity)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030027"(lamellipodium)|go:"GO:0042802"(identical protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|interpro:IPR001452(Src homology-3)|interpro:IPR003127(Sorbin-like)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR028506|interpro:IPR036028|mint:O94875|rcsb pdb:5VEI|refseq:NP_001139142.1|refseq:NP_001139144.1|refseq:NP_001139145.1|refseq:NP_066547.1|refseq:NP_001139146.1|refseq:NP_001139143.1|refseq:NP_001257700.1|refseq:NP_003594.3|refseq:XP_005263369.1|refseq:XP_006714453.1|refseq:XP_016864260.1|dip:DIP-31634N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:ficlNf23am8NpwQVRUKXeVUJTsQ9606	rigid:xiLv1dH/qgREN7IuQsTBT3R60PA	false	sufficient binding region:1219-1731	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q92844	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-356349|uniprotkb:Q92885|uniprotkb:D3DPB5|ensembl:ENSP00000259075|ensembl:ENSP00000376505|uniprotkb:Q7Z4J6	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:tank_human(display_long)|uniprotkb:TANK(gene name)|psi-mi:TANK(display_short)|uniprotkb:ITRAF(gene name synonym)|uniprotkb:TRAF2(gene name synonym)|uniprotkb:TRAF-interacting protein(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514939|imex:IM-28561-475	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_001186064.1|refseq:NP_004171.2|refseq:NP_597841.1|go:"GO:2000158"(positive regulation of ubiquitin-specific protease activity)|interpro:IPR024581|interpro:IPR039669|interpro:IPR041641|mint:Q92844|rcsb pdb:1KZZ|rcsb pdb:1L0A|rcsb pdb:5H10|reactome:R-HSA-9013973|reactome:R-HSA-933541|reactome:R-HSA-936964|go:"GO:1903003"(positive regulation of protein deubiquitination)|ensembl:ENST00000259075(transcript)|ensembl:ENST00000392749(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035800"(deubiquitinase activator activity)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071479"(cellular response to ionizing radiation)|ensembl:ENSG00000136560(gene)|refseq:XP_016858585.1|refseq:XP_016858586.1|dip:DIP-27516N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:B6PUVX1PZ5XmFszyF0tRSwfbb4M9606	rigid:tKGRHJsll05tyui1W81ZOvaGu6A	false	sufficient binding region:374-740	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q96R06	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-413317|uniprotkb:O95213|uniprotkb:Q9BWE8|uniprotkb:Q9NT17|uniprotkb:Q9UFE6|intact:EBI-28972684|ensembl:ENSP00000323300	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:spag5_human(display_long)|uniprotkb:SPAG5(gene name)|psi-mi:SPAG5(display_short)|uniprotkb:Astrin(gene name synonym)|uniprotkb:Mitotic spindle-associated protein p126(gene name synonym)|uniprotkb:Deepest(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514948|imex:IM-28561-711	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_006452.3|ensembl:ENSP00000323300|ensembl:ENSG00000076382(gene)|ensembl:ENST00000321765(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000776"(kinetochore)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007051"(spindle organization)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008017"(microtubule binding)|go:"GO:0016604"(nuclear body)|go:"GO:0030496"(midbody)|go:"GO:0032388"(positive regulation of intracellular transport)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035253"(ciliary rootlet)|go:"GO:0035371"(microtubule plus-end)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051294"(establishment of spindle orientation)|go:"GO:0051301"(cell division)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090235"(regulation of metaphase plate congression)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:1905832"(positive regulation of spindle assembly)|interpro:IPR028728|mint:Q96R06|dip:DIP-30998N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:WOMksaINKpqSxqeGIzbmcSRcgdw9606	rigid:OgOxOp+x+QKr9bMm7YGUqA76fM8	false	sufficient binding region:1219-1731	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q86UX6	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-1050045|uniprotkb:Q5T0Q5|uniprotkb:Q86UE1|ensembl:ENSP00000298630	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:st32c_human(display_long)|uniprotkb:YANK3(gene name synonym)|uniprotkb:STK32C(gene name)|psi-mi:STK32C(display_short)|uniprotkb:PKE(gene name synonym)|uniprotkb:Yet another novel kinase 3(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514957|imex:IM-28561-925	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_775846.2|refseq:NP_001305808.1|refseq:XP_011537995.1|refseq:XP_011537996.1|refseq:XP_011537997.1|refseq:XP_011537998.1|ensembl:ENSG00000165752(gene)|ensembl:ENST00000298630(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0046872"(metal ion binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:cW4MbTwwuaJ37mTA+vKyFIN01EE9606	rigid:/yje7MWB8l673mk+serydAp5B70	false	sufficient binding region:791-1222	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q96PV0	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-2682386|uniprotkb:Q9UGE2|uniprotkb:A8MQC4|uniprotkb:Q8TCS2|uniprotkb:A2AB17|uniprotkb:A2BEL6|uniprotkb:A2BEL7|intact:EBI-28975552|ensembl:ENSP00000414259|ensembl:ENSP00000486463|ensembl:ENSP00000496007	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:sygp1_human(display_long)|uniprotkb:KIAA1938(gene name synonym)|uniprotkb:Neuronal RasGAP(gene name synonym)|uniprotkb:Synaptic Ras GTPase-activating protein 1(gene name synonym)|uniprotkb:SYNGAP1(gene name)|psi-mi:SYNGAP1(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514966|imex:IM-28561-1629	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	ensembl:ENST00000628646|ensembl:ENSP00000486431|ensembl:ENSP00000486463|ensembl:ENSP00000496007|ensembl:ENST00000395071|ensembl:ENSP00000378509|ensembl:ENST00000414753|ensembl:ENSP00000407995|ensembl:ENST00000418600|ensembl:ENSP00000403636|ensembl:ENST00000428982|ensembl:ENSP00000412475|ensembl:ENSP00000414259|refseq:NP_006763.2|refseq:NP_001123538.1|ensembl:ENSG00000197283(gene)|ensembl:ENSG00000227460(gene)|ensembl:ENST00000455687(transcript)|ensembl:ENST00000629380(transcript)|ensembl:ENST00000646630(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007389"(pattern specification process)|go:"GO:0008542"(visual learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021887|interpro:IPR023152|interpro:IPR035892|interpro:IPR037779|interpro:IPR039360|mint:Q96PV0|reactome:R-HSA-5658442	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:3Uq2PiuV/QQyjjPbPJS+CgN8+W89606	rigid:YRq1TCuXXhAsCOG8el06EBL9RbM	false	sufficient binding region:374-740	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:O00445	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-726760|uniprotkb:Q86X72|uniprotkb:B7Z300|uniprotkb:B3KWJ8|ensembl:ENSP00000346265|ensembl:ENSP00000442896	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:syt5_human(display_long)|uniprotkb:Synaptotagmin V(gene name synonym)|uniprotkb:SYT5(gene name)|psi-mi:SYT5(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514975|imex:IM-28561-1137	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_003171.2|refseq:NP_001284703.1|refseq:XP_016882664.1|refseq:XP_016882665.1|refseq:XP_006723402.1|ensembl:ENSG00000129990(gene)|ensembl:ENST00000354308(transcript)|ensembl:ENST00000537500(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0017158"(regulation of calcium ion-dependent exocytosis)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030276"(clathrin binding)|go:"GO:0030424"(axon)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031045"(dense core granule)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048791"(calcium ion-regulated exocytosis of neurotransmitter)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0099066"(integral component of neuronal dense core vesicle membrane)|go:"GO:1990769"(proximal neuron projection)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001565(Synaptotagmin)|interpro:IPR028689|interpro:IPR035892|rcsb pdb:5H4Y|rcsb pdb:5H4Z|reactome:R-HSA-422356|go:"GO:0070382"(exocytic vesicle)	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:bPHhOdMypv9Qg8BqIPbWr3PffUA9606	rigid:MOtqQcH9b1qlJzK9GsUXgndBPH4	false	sufficient binding region:374-740	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:P55036	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-359318|uniprotkb:Q5VWC5|uniprotkb:Q9NS92|uniprotkb:D3DV16|ensembl:ENSP00000357879	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:psmd4_human(display_long)|uniprotkb:PSMD4(gene name)|psi-mi:PSMD4(display_short)|uniprotkb:MCB1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S5A(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN10(gene name synonym)|uniprotkb:Multiubiquitin chain-binding protein(gene name synonym)|uniprotkb:Antisecretory factor 1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514759|imex:IM-28561-55	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_002801.1|dip:DIP-38189N|ensembl:ENSG00000159352(gene)|ensembl:ENST00000368884(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043248"(proteasome assembly)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR036465|mint:P55036|rcsb pdb:1P9C|rcsb pdb:1P9D|rcsb pdb:1UEL|rcsb pdb:1YX4|rcsb pdb:1YX5|rcsb pdb:1YX6|rcsb pdb:2KDE|rcsb pdb:2KDF|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6MUN|rcsb pdb:6U19|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:FTJG3ns3Ag/Y3xP3yEydGxppRcA9606	rigid:FEsGco2+sF9Qtsaa8PrdJ4YUmUI	false	sufficient binding region:1219-1731,791-1222	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q9BQ70	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-745182|uniprotkb:Q2MK75|uniprotkb:Q9UPV3|ensembl:ENSP00000263346|ensembl:ENSP00000491638	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:tcf25_human(display_long)|uniprotkb:Nuclear localized protein 1(gene name synonym)|uniprotkb:TCF25(gene name)|psi-mi:TCF25(display_short)|uniprotkb:KIAA1049(gene name synonym)|uniprotkb:NULP1(gene name synonym)|uniprotkb:FKSG26(orf name)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514984|imex:IM-28561-1631	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_055787.1|ensembl:ENSG00000141002(gene)|ensembl:ENST00000263346(transcript)|ensembl:ENST00000640279(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0007507"(heart development)|go:"GO:1990112"(RQC complex)|interpro:IPR006994(Basic helix-loop-helix, Nulp1-type)|interpro:IPR011990(Tetratricopeptide-like helical)	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:+UEKIIV2LaFWrqJiOWgGU74ITVM9606	rigid:SGP0ONJus8/mDoQvYQmYpJOMlKU	false	sufficient binding region:1219-1731	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q13114	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-357631|uniprotkb:Q12990|uniprotkb:Q13076|uniprotkb:Q13947|uniprotkb:Q6AZX1|uniprotkb:Q9UNL1|ensembl:ENSP00000376500|ensembl:ENSP00000454207|uniprotkb:B7Z8C4	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:traf3_human(display_long)|uniprotkb:TRAF3(gene name)|psi-mi:TRAF3(display_short)|uniprotkb:CAP1(gene name synonym)|uniprotkb:CRAF1(gene name synonym)|uniprotkb:CD40 receptor-associated factor 1(gene name synonym)|uniprotkb:CD40-binding protein(gene name synonym)|uniprotkb:LMP1-associated protein 1(gene name synonym)|uniprotkb:CAP-1(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF3(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515038|imex:IM-28561-853	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	ensembl:ENSG00000131323(gene)|ensembl:ENST00000392745(transcript)|ensembl:ENST00000560371(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|refseq:NP_001186356.1|refseq:NP_003291.2|refseq:NP_663777.1|refseq:NP_663778.1|go:"GO:0007165"(signal transduction)|go:"GO:0008063"(Toll signaling pathway)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032648"(regulation of interferon-beta production)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0035666"(TRIF-dependent toll-like receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050688"(regulation of defense response to virus)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR027128|interpro:IPR037304|interpro:IPR043211|mint:Q13114|go:"GO:0042981"(regulation of apoptotic process)|rcsb pdb:1FLK|rcsb pdb:1FLL|rcsb pdb:1L0A|rcsb pdb:1RF3|rcsb pdb:1ZMS|rcsb pdb:2ECY|rcsb pdb:2GKW|rcsb pdb:1KZZ|refseq:XP_011535420.1|reactome:R-HSA-5668541|reactome:R-HSA-5676594|reactome:R-HSA-5689896|reactome:R-HSA-9013973|reactome:R-HSA-918233|reactome:R-HSA-936440|reactome:R-HSA-936964|reactome:R-HSA-5602571|refseq:XP_016877106.1|refseq:XP_016877107.1|dip:DIP-6222N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:9Tjx/USypDBBrPVyFOsLzM/bwzA9606	rigid:WzzoeQvCeoJhW+2Kx1tzhwU6m48	false	sufficient binding region:791-1222	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q8NFZ5	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-359372|uniprotkb:Q7L5L2|uniprotkb:Q9BQR6|uniprotkb:Q9H682|uniprotkb:B1AKS4|uniprotkb:B3KTY8|uniprotkb:D3DVQ9|ensembl:ENSP00000321203	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:tnip2_human(display_long)|uniprotkb:TNIP2(gene name)|psi-mi:TNIP2(display_short)|uniprotkb:ABIN2(gene name synonym)|uniprotkb:FLIP1(gene name synonym)|uniprotkb:Fetal liver LKB1-interacting protein(gene name synonym)|uniprotkb:A20-binding inhibitor of NF-kappa-B activation 2(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515029|imex:IM-28561-659	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_001154999.1|refseq:NP_077285.3|ensembl:ENSG00000168884(gene)|ensembl:ENST00000315423(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR022008|interpro:IPR034735|mint:Q8NFZ5|rcsb pdb:5H07|reactome:R-HSA-5684264|reactome:R-HSA-5689896|refseq:NP_001278945.1|dip:DIP-27617N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:K9Ee06++lTFEHy1d/3tMu6uwyU09606	rigid:nLIYMEseonO/WpktcC714MwXWBQ	false	sufficient binding region:1-417,791-1222	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q8NHU6	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-624505|uniprotkb:A6NCI6|uniprotkb:Q5VV27|uniprotkb:Q96JT1|uniprotkb:Q9UFF0|uniprotkb:Q9Y2M3|uniprotkb:B4DG99|uniprotkb:B4DXF7|uniprotkb:E7EQD4|uniprotkb:B2RBX3|ensembl:ENSP00000347444	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:tdrd7_human(display_long)|uniprotkb:PCTAIRE2-binding protein(gene name synonym)|uniprotkb:PCTAIRE2BP(gene name synonym)|uniprotkb:TDRD7(gene name)|psi-mi:TDRD7(display_short)|uniprotkb:Tudor repeat associator with PCTAIRE-2(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26514993|imex:IM-28561-63	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_001289813.1|refseq:NP_055105.2|rcsb pdb:3RCO|ensembl:ENSG00000196116(gene)|ensembl:ENST00000355295(transcript)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0003729"(mRNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0033391"(chromatoid body)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0070306"(lens fiber cell differentiation)|interpro:IPR002999(Tudor)|interpro:IPR025605|interpro:IPR035437|interpro:IPR037978|interpro:IPR041966|mint:Q8NHU6	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:VMaw7t5OgA2O0RRDagDVSc+vUUU9606	rigid:HSRGlg1zYjR6YaECCP4kk5MJjRo	false	sufficient binding region:791-1222	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q9Y2W1	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-352039|uniprotkb:Q5VTK6|uniprotkb:D3DPS5|ensembl:ENSP00000346634|ensembl:ENSP00000433825	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:tr150_human(display_long)|uniprotkb:BCLAF1 and THRAP3 family member 2(gene name synonym)|uniprotkb:BCLAF2(gene name synonym)|uniprotkb:THRAP3(gene name)|psi-mi:THRAP3(display_short)|uniprotkb:TRAP150(gene name synonym)|uniprotkb:Thyroid hormone receptor-associated protein complex 150 kDa component(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515011|imex:IM-28561-657	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_005110.2|ensembl:ENSG00000054118(gene)|ensembl:ENST00000354618(transcript)|ensembl:ENST00000469141(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008380"(RNA splicing)|go:"GO:0016592"(mediator complex)|go:"GO:0016607"(nuclear speck)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0042809"(vitamin D receptor binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046966"(thyroid hormone receptor binding)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR026667|interpro:IPR029199|mint:Q9Y2W1|reactome:R-HSA-1989781|reactome:R-HSA-381340|refseq:NP_001308400.1|refseq:NP_001308402.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:pPyZVG1IXg/+QDpHngwzUX09cBM9606	rigid:7kDQCM6i4dva8oQe2w3pfF0JMOE	false	sufficient binding region:791-1222	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q9UBB9	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-1105213|uniprotkb:O95908|uniprotkb:Q5H8V8|uniprotkb:Q9UGV7|uniprotkb:Q9Y2Q8|ensembl:ENSP00000383892|ensembl:ENSP00000384297|ensembl:ENSP00000384421|ensembl:ENSP00000480171|ensembl:ENSP00000385861|uniprotkb:Q20WL0	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:tfp11_human(display_long)|uniprotkb:TFIP11(gene name)|psi-mi:TFIP11(display_short)|uniprotkb:HSPC006(orf name)|uniprotkb:STIP(gene name synonym)|uniprotkb:Septin and tuftelin-interacting protein 1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515002|imex:IM-28561-1395	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	ensembl:ENSG00000100109(gene)|refseq:NP_001008697.1|refseq:NP_036275.1|go:"GO:0016607"(nuclear speck)|ensembl:ENST00000405938(transcript)|ensembl:ENST00000407148(transcript)|ensembl:ENST00000407431(transcript)|ensembl:ENST00000407690(transcript)|ensembl:ENST00000619735(transcript)|go:"GO:0000390"(spliceosomal complex disassembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006396"(RNA processing)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031848"(protection from non-homologous end joining at telomere)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0071008"(U2-type post-mRNA release spliceosomal complex)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1904876"(negative regulation of DNA ligase activity)|go:"GO:2001033"(negative regulation of double-strand break repair via nonhomologous end joining)|interpro:IPR000467(D111/G-patch)|interpro:IPR022159|interpro:IPR022783|interpro:IPR024933|mint:Q9UBB9|reactome:R-HSA-72163|refseq:XP_011528381.1|refseq:XP_016884224.1|refseq:NP_001333786.1|refseq:NP_001333787.1|refseq:NP_001333788.1|refseq:NP_001333790.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:Brk0v9dAoy5ntoJVHFsvt+FFE3g9606	rigid:bmZfQfD9xRMHl6fASEOG8Q7yCSw	false	sufficient binding region:374-740	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q9P0S9	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-2339195|uniprotkb:Q5T4I6|ensembl:ENSP00000229563|ensembl:ENSP00000444561|ensembl:ENSP00000495127|ensembl:ENSP00000495742	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:tm14c_human(display_long)|uniprotkb:TMEM14C(gene name)|psi-mi:TMEM14C(display_short)|uniprotkb:C6orf53(gene name synonym)|uniprotkb:HSPC194(orf name)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515020|imex:IM-28561-397	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_001158730.1|refseq:NP_057546.1|ensembl:ENSG00000111843(gene)|ensembl:ENSG00000284936(gene)|ensembl:ENST00000229563(transcript)|ensembl:ENST00000541412(transcript)|ensembl:ENST00000642513(transcript)|ensembl:ENST00000643226(transcript)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0070453"(regulation of heme biosynthetic process)|interpro:IPR005349(Protein of unknown function UPF0136, Transmembrane)|interpro:IPR044890|mint:Q9P0S9|rcsb pdb:2LOS	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:2wqwjWske9Rf+9F2lDMe35p5Tr89606	rigid:oyP8DcOZTzMJ7sYta71C2Ht9teA	false	sufficient binding region:791-1222	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:P09936	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-714860|uniprotkb:Q71UM0|intact:EBI-1049220|uniprotkb:Q4W5K6|ensembl:ENSP00000284440|ensembl:ENSP00000422542	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:uchl1_human(display_long)|uniprotkb:Ubiquitin thioesterase L1(gene name synonym)|uniprotkb:Neuron cytoplasmic protein 9.5(gene name synonym)|uniprotkb:PGP 9.5(gene name synonym)|uniprotkb:UCHL1(gene name)|psi-mi:UCHL1(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515092|imex:IM-28561-399	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_004172.2|ensembl:ENSG00000154277(gene)|ensembl:ENST00000284440(transcript)|ensembl:ENST00000503431(transcript)|go:"GO:0002931"(response to ischemia)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0007412"(axon target recognition)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008242"(omega peptidase activity)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016874"(ligase activity)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019896"(axonal transport of mitochondrion)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031694"(alpha-2A adrenergic receptor binding)|go:"GO:0035690"|go:"GO:0042755"(eating behavior)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0050905"(neuromuscular process)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR001578(Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1)|interpro:IPR030297|interpro:IPR036959|interpro:IPR038765|mint:P09936|rcsb pdb:2ETL|rcsb pdb:2LEN|rcsb pdb:3IFW|rcsb pdb:3IRT|rcsb pdb:3KVF|rcsb pdb:3KW5|rcsb pdb:4DM9|rcsb pdb:4JKJ|reactome:R-HSA-5689603|go:"GO:0055001"(muscle cell development)|dip:DIP-36620N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:bQ3cxdH+e5fTg7KZ1wjHcOd9cIs9606	rigid:7Tt06UzPWxiQ9VxrLt1ubCIayaw	false	sufficient binding region:791-1222	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q9BQE3	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-1103245|ensembl:ENSP00000301072	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:tba1c_human(display_long)|uniprotkb:TUBA1C(gene name)|psi-mi:TUBA1C(display_short)|uniprotkb:TUBA6(gene name synonym)|uniprotkb:Tubulin alpha-6 chain(gene name synonym)|uniprotkb:Alpha-tubulin 6(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515083|imex:IM-28561-1079	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	reactome:R-HSA-5620924|reactome:R-HSA-5626467|reactome:R-HSA-5663220|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8852276|reactome:R-HSA-8955332|ensembl:ENSG00000167553(gene)|ensembl:ENST00000301072(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0007017"(microtubule-based process)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0031982"(vesicle)|go:"GO:0051301"(cell division)|interpro:IPR000217(Tubulin)|interpro:IPR002452(Alpha tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:Q9BQE3|reactome:R-HSA-1445148|reactome:R-HSA-190840|reactome:R-HSA-190861|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3371497|reactome:R-HSA-380320|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-389977|reactome:R-HSA-437239|reactome:R-HSA-5610787|reactome:R-HSA-5617833|reactome:R-HSA-9609690|reactome:R-HSA-9609736|reactome:R-HSA-9619483|reactome:R-HSA-9646399|reactome:R-HSA-9648025|reactome:R-HSA-9668328|reactome:R-HSA-983189|refseq:NP_116093.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:53r1CNUJNgCreVCw4riUsTPh+yw9606	rigid:+2H7DKM2up2UFKi9W1nVjCleGLI	false	sufficient binding region:791-1222	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q99816	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-346882|uniprotkb:Q9BUM5|ensembl:ENSP00000251968	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:ts101_human(display_long)|uniprotkb:TSG101(gene name)|psi-mi:TSG101(display_short)|uniprotkb:ESCRT-I complex subunit TSG101(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515074|imex:IM-28561-1539	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_006283.1|ensembl:ENSP00000251968|dip:DIP-31809N|ensembl:ENSG00000074319(gene)|ensembl:ENST00000251968(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000813"(ESCRT I complex)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0003677"(DNA binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006858"(extracellular transport)|go:"GO:0007049"(cell cycle)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016236"(macroautophagy)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0036258"(multivesicular body assembly)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043405"(regulation of MAP kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046755"(viral budding)|go:"GO:0046790"(virion binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090543"(Flemming body)|go:"GO:0097352"(autophagosome maturation)|go:"GO:1902188"(obsolete positive regulation of viral release from host cell)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903551"(regulation of extracellular exosome assembly)|go:"GO:1903774"(positive regulation of viral budding via host ESCRT complex)|go:"GO:1990182"(exosomal secretion)|go:"GO:2000397"(positive regulation of ubiquitin-dependent endocytosis)|interpro:IPR008883(Tumour susceptibility gene 101)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR017916|interpro:IPR037202|mint:Q99816|rcsb pdb:1KPP|rcsb pdb:1KPQ|rcsb pdb:1M4P|rcsb pdb:1M4Q|rcsb pdb:1S1Q|rcsb pdb:2F0R|rcsb pdb:3IV1|rcsb pdb:3OBQ|rcsb pdb:3OBS|rcsb pdb:3OBU|rcsb pdb:3OBX|rcsb pdb:3P9G|rcsb pdb:3P9H|rcsb pdb:4EJE|rcsb pdb:4YC1|rcsb pdb:4ZNY|rcsb pdb:5VKG|rcsb pdb:6UD0|rcsb pdb:6VME|reactome:R-HSA-162588|reactome:R-HSA-174490|reactome:R-HSA-917729|reactome:R-HSA-9610379|reactome:R-HSA-9615710	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:hoi+Pw0Rr3wL/1ePQINUq3BmSFI9606	rigid:auR0YzJsg5Rx2RcfLyxk7WZhn84	false	sufficient binding region:791-1222	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q15642	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-739936|uniprotkb:O15184|uniprotkb:Q53G22|uniprotkb:Q5TZN1|uniprotkb:Q6FI24|uniprotkb:Q8NFL1|uniprotkb:Q8TCY1|uniprotkb:Q8TDX3|uniprotkb:Q96RJ1|uniprotkb:B2R8A6|uniprotkb:B7WP22|uniprotkb:D6W645|intact:EBI-28977062|ensembl:ENSP00000320117	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:cip4_human(display_long)|uniprotkb:TRIP10(gene name)|psi-mi:TRIP10(display_short)|uniprotkb:CIP4(gene name synonym)|uniprotkb:Thyroid receptor-interacting protein 10(gene name synonym)|uniprotkb:Protein Felic(gene name synonym)|uniprotkb:Salt tolerant protein(gene name synonym)|uniprotkb:STOT(gene name synonym)|uniprotkb:STP(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515065|imex:IM-28561-857	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	ensembl:ENSP00000320117|ensembl:ENST00000313285|ensembl:ENSP00000320493|refseq:NP_004231.1|ensembl:ENSG00000125733(gene)|ensembl:ENST00000313244(transcript)|go:"GO:0001891"(phagocytic cup)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005938"(cell cortex)|go:"GO:0006897"(endocytosis)|go:"GO:0007154"(cell communication)|go:"GO:0007165"(signal transduction)|go:"GO:0008289"(lipid binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|interpro:IPR027267|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR001452(Src homology-3)|interpro:IPR011072(HR1 rho-binding repeat)|interpro:IPR028498|interpro:IPR031160|interpro:IPR036028|mint:Q15642|rcsb pdb:2CT4|rcsb pdb:2EFK|rcsb pdb:2KE4|reactome:R-HSA-8856828|reactome:R-HSA-9013406|refseq:NP_001275891.1|refseq:NP_001275892.1|dip:DIP-39840N	-	-	crc64:A9BFE85520C7ABC5	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:6DvFGTlXvKhqvKlLcV1sRucCKzo9606	rigid:ypLdMLjEh3CyvwJp21hsyNQmGXQ	false	sufficient binding region:791-1222	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q9C026	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-720828|ensembl:ENSP00000298355|uniprotkb:Q92557|uniprotkb:Q96D24|uniprotkb:Q96NI4|uniprotkb:Q9C025|uniprotkb:Q9C027|uniprotkb:D3DSB7|uniprotkb:D3DSB8	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:trim9_human(display_long)|uniprotkb:RING finger protein 91(gene name synonym)|uniprotkb:TRIM9(gene name)|psi-mi:TRIM9(display_short)|uniprotkb:KIAA0282(gene name synonym)|uniprotkb:RNF91(gene name synonym)|uniprotkb:Tripartite motif-containing protein 9(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRIM9(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515056|imex:IM-28561-199	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	ensembl:ENSG00000100505(gene)|ensembl:ENST00000298355(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030425"(dendrite)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003649(B-box, C-terminal)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017903|interpro:IPR017907|interpro:IPR036116|interpro:IPR043136|rcsb pdb:2DB8|rcsb pdb:7B2S|reactome:R-HSA-983168|refseq:XP_011534691.1|refseq:NP_055978.4|refseq:NP_443210.1|refseq:XP_016876434.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:cWf6NobHVvKBKNqclJsLeoJKfMw9606	rigid:RirXu7JF41dilu+h9S3Nx4GhY+o	false	sufficient binding region:1219-1731	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:P14373	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-719493|uniprotkb:A2BE15|uniprotkb:Q5RJA8|uniprotkb:Q5ST26|uniprotkb:Q6LA73|uniprotkb:Q6NXR9|uniprotkb:Q9BZY6|uniprotkb:Q9UJL3|ensembl:ENSP00000383555|ensembl:ENSP00000392787|ensembl:ENSP00000405229|ensembl:ENSP00000414793|ensembl:ENSP00000366404	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:tri27_human(display_long)|uniprotkb:TRIM27(gene name)|psi-mi:TRIM27(display_short)|uniprotkb:RNF76(gene name synonym)|uniprotkb:RFP(gene name synonym)|uniprotkb:Ret finger protein(gene name synonym)|uniprotkb:Tripartite motif-containing protein 27(gene name synonym)|uniprotkb:RING finger protein 76(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRIM27(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515047|imex:IM-28561-855	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_006501.1|go:"GO:0046596"(regulation of viral entry into host cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0090281"(negative regulation of calcium ion import)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR003879(Butyrophylin-like)|interpro:IPR006574(SPRY-associated)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR017907|interpro:IPR020457|interpro:IPR035791|interpro:IPR043136|mint:P14373|reactome:R-HSA-3232142|reactome:R-HSA-9635465|reactome:R-HSA-8948751|ensembl:ENSG00000204713(gene)|ensembl:ENSG00000215641(gene)|ensembl:ENSG00000229006(gene)|ensembl:ENSG00000234495(gene)|ensembl:ENSG00000237071(gene)|ensembl:ENST00000377199(transcript)|ensembl:ENST00000400720(transcript)|ensembl:ENST00000431123(transcript)|ensembl:ENST00000435528(transcript)|ensembl:ENST00000437160(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001650"(fibrillar center)|go:"GO:0002820"(negative regulation of adaptive immune response)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016605"(PML body)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032897"(negative regulation of viral transcription)|go:"GO:0034314"(Arp2/3 complex-mediated actin nucleation)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:dsfH5OUghD8KSaTz1SFw9OYVTK49606	rigid:GqA1aScRvONAwf/QpEgpH8rxdxc	false	sufficient binding region:1219-1731	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q92574	uniprotkb:Q9P2G1	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	intact:EBI-2687890|uniprotkb:Q6GMS4|uniprotkb:Q6P3S9|uniprotkb:Q9NTD7|uniprotkb:Q9NW49|ensembl:ENSP00000265742	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:akib1_human(display_long)|uniprotkb:KIAA1386(gene name synonym)|uniprotkb:ANKIB1(gene name)|psi-mi:ANKIB1(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515413|imex:IM-28561-75	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	refseq:NP_061877.1|ensembl:ENSG00000001629(gene)|ensembl:ENST00000265742(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002110(Ankyrin)|interpro:IPR002867(Zinc finger, C6HC-type)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR031127|interpro:IPR036770|interpro:IPR044066	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	rogid:nGIEObU8El2r+ErOR70g5YOoRo09606	rigid:Hb5SCNmWb27KAVs+tsXz870ORb4	false	sufficient binding region:720-1000	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q92574	uniprotkb:P35609	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	intact:EBI-77797|uniprotkb:Q86TF4|ensembl:ENSP00000355537|uniprotkb:Q86TI8|uniprotkb:B1ANE4|intact:EBI-928705|uniprotkb:B2RCS5	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:actn2_human(display_long)|uniprotkb:ACTN2(gene name)|psi-mi:ACTN2(display_short)|uniprotkb:Alpha-actinin skeletal muscle isoform 2(gene name synonym)|uniprotkb:F-actin cross-linking protein(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515404|imex:IM-28561-1415	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	refseq:NP_001094.1|ensembl:ENSG00000077522(gene)|ensembl:ENST00000366578(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005925"(focal adhesion)|go:"GO:0006936"(muscle contraction)|go:"GO:0007155"(cell adhesion)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030018"(Z disc)|go:"GO:0030035"(microspike assembly)|go:"GO:0030175"(filopodium)|go:"GO:0030274"(LIM domain binding)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031143"(pseudopodium)|go:"GO:0031432"(titin binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043267"(negative regulation of potassium ion transport)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045214"(sarcomere organization)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051015"(actin filament binding)|go:"GO:0051373"(FATZ binding)|go:"GO:0051695"(actin filament uncapping)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070080"(titin Z domain binding)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086097"(phospholipase C-activating angiotensin-activated signaling pathway)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|go:"GO:2001137"(positive regulation of endocytic recycling)|go:"GO:0030374"(nuclear receptor coactivator activity)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR036872|mint:P35609|rcsb pdb:1H8B|rcsb pdb:1HCI|rcsb pdb:1QUU|rcsb pdb:4D1E|rcsb pdb:5A36|rcsb pdb:5A37|rcsb pdb:5A38|rcsb pdb:5A4B|rcsb pdb:6SWT|rcsb pdb:6TS3|rcsb pdb:7A8T|rcsb pdb:7A8U|reactome:R-HSA-114608|go:"GO:2001259"(positive regulation of cation channel activity)|reactome:R-HSA-373753|reactome:R-HSA-390522|reactome:R-HSA-442982|reactome:R-HSA-5673001|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-9620244|reactome:R-HSA-438066|refseq:NP_001265272.1|refseq:NP_001265273.1|dip:DIP-383N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	rogid:9jws8DZxpttkzqPfDxEzORNnwcE9606	rigid:0W79ZJ3VMW+RVoMJDCaKSjw/cmk	false	sufficient binding region:400-724	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q92574	uniprotkb:P12814	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	intact:EBI-351710|uniprotkb:Q9BTN1|uniprotkb:Q1HE25|uniprotkb:B7TY16|intact:EBI-3866221|uniprotkb:B3V8S3|uniprotkb:B4DHH3|ensembl:ENSP00000193403	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:actn1_human(display_long)|uniprotkb:ACTN1(gene name)|psi-mi:ACTN1(display_short)|uniprotkb:Alpha-actinin cytoskeletal isoform(gene name synonym)|uniprotkb:Non-muscle alpha-actinin-1(gene name synonym)|uniprotkb:F-actin cross-linking protein(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515395|imex:IM-28561-1413	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	refseq:NP_001093.1|refseq:NP_001123477.1|refseq:NP_001123476.1|dip:DIP-33184N|ensembl:ENSG00000072110(gene)|ensembl:ENST00000193403(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005916"(fascia adherens)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0017166"(vinculin binding)|go:"GO:0030018"(Z disc)|go:"GO:0030220"(platelet formation)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031143"(pseudopodium)|go:"GO:0036344"(platelet morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0042995"(cell projection)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051271"(negative regulation of cellular component movement)|go:"GO:0051639"(actin filament network formation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099186"(structural constituent of postsynapse)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR018247|interpro:IPR036872|mint:P12814|rcsb pdb:2EYI|rcsb pdb:2EYN|rcsb pdb:2N8Y|rcsb pdb:2N8Z|reactome:R-HSA-114608|reactome:R-HSA-3000170|reactome:R-HSA-373753|reactome:R-HSA-446388|reactome:R-HSA-9013405|reactome:R-HSA-9013418|reactome:R-HSA-9035034	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	rogid:guTURyt26f1ort4NAlYyabNc+WE9606	rigid:XF9VoUYdwbP5fleUxYP78wEsiNM	false	sufficient binding region:720-1000	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q92574	uniprotkb:Q8IZP0	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	intact:EBI-375446|uniprotkb:O15147|uniprotkb:O76049|uniprotkb:O95060|uniprotkb:Q5W070|uniprotkb:Q5W072|uniprotkb:Q8TB63|uniprotkb:Q96S81|uniprotkb:Q9NXZ9|uniprotkb:Q9NYB8|intact:EBI-28968938|ensembl:ENSP00000365312|uniprotkb:A9Z1Y6|uniprotkb:Q5T2R3|uniprotkb:Q5T2R4|uniprotkb:Q5T2R6|uniprotkb:Q5T2R7|uniprotkb:B4DQ58|uniprotkb:Q5T2R9|uniprotkb:B3KX62|uniprotkb:H7BXI6	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:abi1_human(display_long)|uniprotkb:ABI1(gene name)|psi-mi:ABI1(display_short)|uniprotkb:SSH3BP1(gene name synonym)|uniprotkb:Abelson interactor 1(gene name synonym)|uniprotkb:Spectrin SH3 domain-binding protein 1(gene name synonym)|uniprotkb:Eps8 SH3 domain-binding protein(gene name synonym)|uniprotkb:e3B1(gene name synonym)|uniprotkb:Nap1-binding protein(gene name synonym)|uniprotkb:Abl-binding protein 4(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515386|imex:IM-28561-1143	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	refseq:NP_001012768.1|refseq:NP_001012769.1|refseq:NP_001012770.1|refseq:NP_001171590.1|refseq:NP_001171591.1|go:"GO:0030027"(lamellipodium)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0030426"(growth cone)|go:"GO:0031209"(SCAR complex)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045296"(cadherin binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072673"(lamellipodium morphogenesis)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028456|interpro:IPR028457|interpro:IPR035725|interpro:IPR036028|mint:Q8IZP0|ensembl:ENST00000376142(transcript)|go:"GO:0001756"(somitogenesis)|ensembl:ENSG00000136754(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|refseq:NP_001171592.1|refseq:NP_001171593.1|refseq:NP_001171594.1|refseq:NP_001171595.1|refseq:NP_005461.2|ensembl:ENST00000346832|ensembl:ENSP00000279599|ensembl:ENST00000359188|ensembl:ENSP00000352114|ensembl:ENST00000376137|ensembl:ENSP00000365307|ensembl:ENST00000376138|ensembl:ENSP00000365308|ensembl:ENST00000376139|ensembl:ENSP00000365309|ensembl:ENST00000376140|ensembl:ENSP00000365310|ensembl:ENSP00000365312|ensembl:ENST00000376166|ensembl:ENSP00000365336|ensembl:ENST00000376170|ensembl:ENSP00000365340|ensembl:ENST00000490841|ensembl:ENSP00000440101|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9664422|refseq:NP_001171596.1|refseq:NP_001171587.1|dip:DIP-31118N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	rogid:mO2D5R8ZlYmsh+fXdJpaHZOssfs9606	rigid:hy99Fu5Pn1afrKXC+YUGx9bA67Q	false	sufficient binding region:720-1000	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51531	uniprotkb:O75541	intact:EBI-679562|uniprotkb:B1ALG3|uniprotkb:B1ALG4|uniprotkb:D3DRH4|uniprotkb:D3DRH5|ensembl:ENSP00000265773|ensembl:ENSP00000371638	intact:EBI-740865|ensembl:ENSP00000398089|ensembl:ENSP00000455648|uniprotkb:A6NK48|uniprotkb:B4DKK4|uniprotkb:D3DWS3	psi-mi:smca2_human(display_long)|uniprotkb:ATP-dependent helicase SMARCA2(gene name synonym)|uniprotkb:SNF2-alpha(gene name synonym)|uniprotkb:SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2(gene name synonym)|uniprotkb:SMARCA2(gene name)|psi-mi:SMARCA2(display_short)|uniprotkb:BRM(gene name synonym)|uniprotkb:SNF2A(gene name synonym)|uniprotkb:SNF2L2(gene name synonym)|uniprotkb:BAF190B(gene name synonym)|uniprotkb:Protein brahma homolog(gene name synonym)|uniprotkb:BRG1-associated factor 190B(gene name synonym)	psi-mi:zn821_human(display_long)|uniprotkb:ZNF821(gene name)|psi-mi:ZNF821(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515379|imex:IM-28561-933	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003061.3|refseq:NP_620614.2|refseq:NP_001276325.1|refseq:NP_001276326.1|dip:DIP-29005N|ensembl:ENSG00000080503(gene)|ensembl:ENST00000349721(transcript)|ensembl:ENST00000382203(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007286"(spermatid development)|go:"GO:0007399"(nervous system development)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0042393"(histone binding)|go:"GO:0043044"|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070615"|go:"GO:0071564"(npBAF complex)|go:"GO:0071565"(nBAF complex)|interpro:IPR000330(SNF2-related)|interpro:IPR001487(Bromodomain)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006576(BRK)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014012(Helicase/SANT-associated, DNA binding)|interpro:IPR014978(QLQ)|interpro:IPR018359|interpro:IPR027417|interpro:IPR029295|interpro:IPR030088|interpro:IPR036427|interpro:IPR037259|interpro:IPR038718|mint:P51531|rcsb pdb:2DAT|rcsb pdb:4QY4|rcsb pdb:5DKC|rcsb pdb:5DKH|rcsb pdb:6EG2|rcsb pdb:6EG3|rcsb pdb:6HAX|rcsb pdb:6HAY|rcsb pdb:6HAZ|reactome:R-HSA-3214858|reactome:R-HSA-8939243	ensembl:ENSG00000102984(gene)|ensembl:ENST00000425432(transcript)|ensembl:ENST00000565601(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:O75541|refseq:NP_001188483.1|refseq:NP_060000.1|refseq:XP_011521513.1|refseq:NP_001188481.1|refseq:NP_001188482.1|refseq:NP_001188485.1|refseq:XP_006721296.1|refseq:XP_005256090.1|refseq:XP_016878898.1|refseq:XP_016878899.1|refseq:XP_016878900.1|refseq:XP_016878901.1|refseq:XP_016878903.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:DmQot4h4SmtqmUGBgF5ictTah289606	rogid:LzrZF32gwK7sRhoOFlfhgbi7Eno9606	rigid:QtK5vM8g8WJyCV60NTIx9pFmuXE	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51531	uniprotkb:Q13829	intact:EBI-679562|uniprotkb:B1ALG3|uniprotkb:B1ALG4|uniprotkb:D3DRH4|uniprotkb:D3DRH5|ensembl:ENSP00000265773|ensembl:ENSP00000371638	intact:EBI-2505861|uniprotkb:B7Z6M4|uniprotkb:Q5TZQ1|ensembl:ENSP00000226225	psi-mi:smca2_human(display_long)|uniprotkb:ATP-dependent helicase SMARCA2(gene name synonym)|uniprotkb:SNF2-alpha(gene name synonym)|uniprotkb:SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2(gene name synonym)|uniprotkb:SMARCA2(gene name)|psi-mi:SMARCA2(display_short)|uniprotkb:BRM(gene name synonym)|uniprotkb:SNF2A(gene name synonym)|uniprotkb:SNF2L2(gene name synonym)|uniprotkb:BAF190B(gene name synonym)|uniprotkb:Protein brahma homolog(gene name synonym)|uniprotkb:BRG1-associated factor 190B(gene name synonym)	psi-mi:bacd2_human(display_long)|uniprotkb:BACURD2(gene name synonym)|uniprotkb:BTB/POZ domain-containing protein TNFAIP1(gene name synonym)|uniprotkb:Protein B12(gene name synonym)|uniprotkb:TNFAIP1(gene name)|psi-mi:TNFAIP1(display_short)|uniprotkb:EDP1(gene name synonym)|uniprotkb:Tumor necrosis factor, alpha-induced protein 1, endothelial(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515372|imex:IM-28561-1637	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003061.3|refseq:NP_620614.2|refseq:NP_001276325.1|refseq:NP_001276326.1|dip:DIP-29005N|ensembl:ENSG00000080503(gene)|ensembl:ENST00000349721(transcript)|ensembl:ENST00000382203(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007286"(spermatid development)|go:"GO:0007399"(nervous system development)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0042393"(histone binding)|go:"GO:0043044"|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070615"|go:"GO:0071564"(npBAF complex)|go:"GO:0071565"(nBAF complex)|interpro:IPR000330(SNF2-related)|interpro:IPR001487(Bromodomain)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006576(BRK)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014012(Helicase/SANT-associated, DNA binding)|interpro:IPR014978(QLQ)|interpro:IPR018359|interpro:IPR027417|interpro:IPR029295|interpro:IPR030088|interpro:IPR036427|interpro:IPR037259|interpro:IPR038718|mint:P51531|rcsb pdb:2DAT|rcsb pdb:4QY4|rcsb pdb:5DKC|rcsb pdb:5DKH|rcsb pdb:6EG2|rcsb pdb:6EG3|rcsb pdb:6HAX|rcsb pdb:6HAY|rcsb pdb:6HAZ|reactome:R-HSA-3214858|reactome:R-HSA-8939243	refseq:NP_066960.1|ensembl:ENSG00000109079(gene)|ensembl:ENST00000226225(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006955"(immune response)|go:"GO:0016477"(cell migration)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030332"(cyclin binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0051260"(protein homooligomerization)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR003131(Potassium channel, voltage dependent, Kv,  tetramerisation)|interpro:IPR011333(BTB/POZ fold)|mint:Q13829|reactome:R-HSA-9696264|reactome:R-HSA-9696270	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:DmQot4h4SmtqmUGBgF5ictTah289606	rogid:8vM9HnNmkirDbJRETV/TeE8pONY9606	rigid:vazmsS3z+I5aPp6mnMH2lmrv4Ik	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51531	uniprotkb:O95359	intact:EBI-679562|uniprotkb:B1ALG3|uniprotkb:B1ALG4|uniprotkb:D3DRH4|uniprotkb:D3DRH5|ensembl:ENSP00000265773|ensembl:ENSP00000371638	intact:EBI-720382|uniprotkb:Q4VXL6|uniprotkb:Q4VXL7|uniprotkb:Q5U5T7|uniprotkb:Q86WG6|uniprotkb:Q86WG7|uniprotkb:Q4VXL0|uniprotkb:Q4VXL3|uniprotkb:Q8TCK9|uniprotkb:Q9BVQ1|uniprotkb:Q9NZ41|uniprotkb:Q9NZR5|intact:EBI-2558151|intact:EBI-28968297|ensembl:ENSP00000334280|ensembl:ENSP00000358001	psi-mi:smca2_human(display_long)|uniprotkb:ATP-dependent helicase SMARCA2(gene name synonym)|uniprotkb:SNF2-alpha(gene name synonym)|uniprotkb:SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2(gene name synonym)|uniprotkb:SMARCA2(gene name)|psi-mi:SMARCA2(display_short)|uniprotkb:BRM(gene name synonym)|uniprotkb:SNF2A(gene name synonym)|uniprotkb:SNF2L2(gene name synonym)|uniprotkb:BAF190B(gene name synonym)|uniprotkb:Protein brahma homolog(gene name synonym)|uniprotkb:BRG1-associated factor 190B(gene name synonym)	psi-mi:tacc2_human(display_long)|uniprotkb:Anti-Zuai-1(gene name synonym)|uniprotkb:TACC2(gene name)|psi-mi:TACC2(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515365|imex:IM-28561-1141	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003061.3|refseq:NP_620614.2|refseq:NP_001276325.1|refseq:NP_001276326.1|dip:DIP-29005N|ensembl:ENSG00000080503(gene)|ensembl:ENST00000349721(transcript)|ensembl:ENST00000382203(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007286"(spermatid development)|go:"GO:0007399"(nervous system development)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0042393"(histone binding)|go:"GO:0043044"|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070615"|go:"GO:0071564"(npBAF complex)|go:"GO:0071565"(nBAF complex)|interpro:IPR000330(SNF2-related)|interpro:IPR001487(Bromodomain)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006576(BRK)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014012(Helicase/SANT-associated, DNA binding)|interpro:IPR014978(QLQ)|interpro:IPR018359|interpro:IPR027417|interpro:IPR029295|interpro:IPR030088|interpro:IPR036427|interpro:IPR037259|interpro:IPR038718|mint:P51531|rcsb pdb:2DAT|rcsb pdb:4QY4|rcsb pdb:5DKC|rcsb pdb:5DKH|rcsb pdb:6EG2|rcsb pdb:6EG3|rcsb pdb:6HAX|rcsb pdb:6HAY|rcsb pdb:6HAZ|reactome:R-HSA-3214858|reactome:R-HSA-8939243	refseq:NP_001278807.1|refseq:NP_996744.3|refseq:NP_008928.1|refseq:NP_996742.1|refseq:NP_996743.1|ensembl:ENST00000260733|ensembl:ENSP00000260733|ensembl:ENSP00000334280|ensembl:ENST00000358010|ensembl:ENSP00000350701|ensembl:ENST00000360561|ensembl:ENSP00000353763|ensembl:ENST00000369000|ensembl:ENSP00000357996|ensembl:ENSP00000358001|ensembl:ENST00000513429|ensembl:ENSP00000425062|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0021987"(cerebral cortex development)|interpro:IPR007707(Transforming acidic coiled-coil-containing)|interpro:IPR039915|mint:O95359|go:"GO:0008283"(cell population proliferation)|ensembl:ENSG00000138162(gene)|ensembl:ENST00000334433(transcript)|ensembl:ENST00000369005(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007052"(mitotic spindle organization)	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:DmQot4h4SmtqmUGBgF5ictTah289606	rogid:F497RHDDNDqTPKybxJ/DiuhfjAc9606	rigid:681oslMKUFCP6n4WEusPoUdLFPs	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51531	uniprotkb:P63272	intact:EBI-679562|uniprotkb:B1ALG3|uniprotkb:B1ALG4|uniprotkb:D3DRH4|uniprotkb:D3DRH5|ensembl:ENSP00000265773|ensembl:ENSP00000371638	intact:EBI-727250|uniprotkb:Q16550|uniprotkb:Q62387|uniprotkb:Q6ZP89|uniprotkb:B2R4X8|uniprotkb:D3DTZ4|ensembl:ENSP00000225504|ensembl:ENSP00000462670	psi-mi:smca2_human(display_long)|uniprotkb:ATP-dependent helicase SMARCA2(gene name synonym)|uniprotkb:SNF2-alpha(gene name synonym)|uniprotkb:SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2(gene name synonym)|uniprotkb:SMARCA2(gene name)|psi-mi:SMARCA2(display_short)|uniprotkb:BRM(gene name synonym)|uniprotkb:SNF2A(gene name synonym)|uniprotkb:SNF2L2(gene name synonym)|uniprotkb:BAF190B(gene name synonym)|uniprotkb:Protein brahma homolog(gene name synonym)|uniprotkb:BRG1-associated factor 190B(gene name synonym)	psi-mi:spt4h_human(display_long)|uniprotkb:DRB sensitivity-inducing factor small subunit(gene name synonym)|uniprotkb:DRB sensitivity-inducing factor 14 kDa subunit(gene name synonym)|uniprotkb:SUPT4H1(gene name)|psi-mi:SUPT4H1(display_short)|uniprotkb:SPT4H(gene name synonym)|uniprotkb:SUPT4H(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515358|imex:IM-28561-1635	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003061.3|refseq:NP_620614.2|refseq:NP_001276325.1|refseq:NP_001276326.1|dip:DIP-29005N|ensembl:ENSG00000080503(gene)|ensembl:ENST00000349721(transcript)|ensembl:ENST00000382203(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007286"(spermatid development)|go:"GO:0007399"(nervous system development)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0042393"(histone binding)|go:"GO:0043044"|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070615"|go:"GO:0071564"(npBAF complex)|go:"GO:0071565"(nBAF complex)|interpro:IPR000330(SNF2-related)|interpro:IPR001487(Bromodomain)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006576(BRK)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014012(Helicase/SANT-associated, DNA binding)|interpro:IPR014978(QLQ)|interpro:IPR018359|interpro:IPR027417|interpro:IPR029295|interpro:IPR030088|interpro:IPR036427|interpro:IPR037259|interpro:IPR038718|mint:P51531|rcsb pdb:2DAT|rcsb pdb:4QY4|rcsb pdb:5DKC|rcsb pdb:5DKH|rcsb pdb:6EG2|rcsb pdb:6EG3|rcsb pdb:6HAX|rcsb pdb:6HAY|rcsb pdb:6HAZ|reactome:R-HSA-3214858|reactome:R-HSA-8939243	refseq:NP_003159.1|ensembl:ENSG00000213246(gene)|ensembl:ENST00000225504(transcript)|ensembl:ENST00000580947(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006325"(chromatin organization)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006397"(mRNA processing)|go:"GO:0008270"(zinc ion binding)|go:"GO:0032044"(DSIF complex)|go:"GO:0032785"(negative regulation of DNA-templated transcription, elongation)|go:"GO:0032786"(positive regulation of DNA-templated transcription, elongation)|go:"GO:0034243"(regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR009287(Transcription initiation Spt4)|interpro:IPR022800|interpro:IPR029040|interpro:IPR038510|mint:P63272|rcsb pdb:3H7H|rcsb pdb:5OIK|rcsb pdb:6GMH|rcsb pdb:6GML|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167242|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6807505|reactome:R-HSA-75955|dip:DIP-40644N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:DmQot4h4SmtqmUGBgF5ictTah289606	rogid:dz+Mu8lTSRS/nIQ+RUKWIiJAwTE9606	rigid:ZC9rccyQRT8ht1TOkvumsV0BKc0	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51531	uniprotkb:P28290	intact:EBI-679562|uniprotkb:B1ALG3|uniprotkb:B1ALG4|uniprotkb:D3DRH4|uniprotkb:D3DRH5|ensembl:ENSP00000265773|ensembl:ENSP00000371638	intact:EBI-722905|uniprotkb:Q8N7H2|uniprotkb:Q7Z7L2|uniprotkb:Q8N1L3|uniprotkb:Q8N263|uniprotkb:Q8NEN5|uniprotkb:Q96E36|uniprotkb:Q68DA6|uniprotkb:Q96PW1|uniprotkb:A8K6T0|intact:EBI-28986959|ensembl:ENSP00000388731	psi-mi:smca2_human(display_long)|uniprotkb:ATP-dependent helicase SMARCA2(gene name synonym)|uniprotkb:SNF2-alpha(gene name synonym)|uniprotkb:SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2(gene name synonym)|uniprotkb:SMARCA2(gene name)|psi-mi:SMARCA2(display_short)|uniprotkb:BRM(gene name synonym)|uniprotkb:SNF2A(gene name synonym)|uniprotkb:SNF2L2(gene name synonym)|uniprotkb:BAF190B(gene name synonym)|uniprotkb:Protein brahma homolog(gene name synonym)|uniprotkb:BRG1-associated factor 190B(gene name synonym)	psi-mi:itpi2_human(display_long)|uniprotkb:ITPRID2(gene name)|psi-mi:ITPRID2(display_short)|uniprotkb:CS1(gene name synonym)|uniprotkb:Cleavage signal-1 protein(gene name synonym)|uniprotkb:ITPR-interacting domain-containing protein 2(gene name synonym)|uniprotkb:KIAA1927(gene name synonym)|uniprotkb:KRAP(gene name synonym)|uniprotkb:Ki-ras-induced actin-interacting protein(gene name synonym)|uniprotkb:SSFA2(gene name synonym)|uniprotkb:Sperm-specific antigen 2(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515351|imex:IM-28561-271	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003061.3|refseq:NP_620614.2|refseq:NP_001276325.1|refseq:NP_001276326.1|dip:DIP-29005N|ensembl:ENSG00000080503(gene)|ensembl:ENST00000349721(transcript)|ensembl:ENST00000382203(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007286"(spermatid development)|go:"GO:0007399"(nervous system development)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0042393"(histone binding)|go:"GO:0043044"|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070615"|go:"GO:0071564"(npBAF complex)|go:"GO:0071565"(nBAF complex)|interpro:IPR000330(SNF2-related)|interpro:IPR001487(Bromodomain)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006576(BRK)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014012(Helicase/SANT-associated, DNA binding)|interpro:IPR014978(QLQ)|interpro:IPR018359|interpro:IPR027417|interpro:IPR029295|interpro:IPR030088|interpro:IPR036427|interpro:IPR037259|interpro:IPR038718|mint:P51531|rcsb pdb:2DAT|rcsb pdb:4QY4|rcsb pdb:5DKC|rcsb pdb:5DKH|rcsb pdb:6EG2|rcsb pdb:6EG3|rcsb pdb:6HAX|rcsb pdb:6HAY|rcsb pdb:6HAZ|reactome:R-HSA-3214858|reactome:R-HSA-8939243	refseq:NP_001123917.1|refseq:NP_006742.2|refseq:NP_001274432.1|refseq:NP_001274433.1|ensembl:ENST00000320370|ensembl:ENSP00000314669|ensembl:ENSP00000388731|dip:DIP-47271N|ensembl:ENSG00000138434(gene)|ensembl:ENST00000431877(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0051015"(actin filament binding)|interpro:IPR026648|interpro:IPR029325|interpro:IPR029326|interpro:IPR043444	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:DmQot4h4SmtqmUGBgF5ictTah289606	rogid:oLYBDg++fr2C4VnIkkP5xhll5dw9606	rigid:hXxdw98l3obUGpKYO20XvT7+bms	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51531	uniprotkb:Q96R06	intact:EBI-679562|uniprotkb:B1ALG3|uniprotkb:B1ALG4|uniprotkb:D3DRH4|uniprotkb:D3DRH5|ensembl:ENSP00000265773|ensembl:ENSP00000371638	intact:EBI-413317|uniprotkb:O95213|uniprotkb:Q9BWE8|uniprotkb:Q9NT17|uniprotkb:Q9UFE6|intact:EBI-28972684|ensembl:ENSP00000323300	psi-mi:smca2_human(display_long)|uniprotkb:ATP-dependent helicase SMARCA2(gene name synonym)|uniprotkb:SNF2-alpha(gene name synonym)|uniprotkb:SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2(gene name synonym)|uniprotkb:SMARCA2(gene name)|psi-mi:SMARCA2(display_short)|uniprotkb:BRM(gene name synonym)|uniprotkb:SNF2A(gene name synonym)|uniprotkb:SNF2L2(gene name synonym)|uniprotkb:BAF190B(gene name synonym)|uniprotkb:Protein brahma homolog(gene name synonym)|uniprotkb:BRG1-associated factor 190B(gene name synonym)	psi-mi:spag5_human(display_long)|uniprotkb:SPAG5(gene name)|psi-mi:SPAG5(display_short)|uniprotkb:Astrin(gene name synonym)|uniprotkb:Mitotic spindle-associated protein p126(gene name synonym)|uniprotkb:Deepest(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515344|imex:IM-28561-713	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003061.3|refseq:NP_620614.2|refseq:NP_001276325.1|refseq:NP_001276326.1|dip:DIP-29005N|ensembl:ENSG00000080503(gene)|ensembl:ENST00000349721(transcript)|ensembl:ENST00000382203(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007286"(spermatid development)|go:"GO:0007399"(nervous system development)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0042393"(histone binding)|go:"GO:0043044"|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070615"|go:"GO:0071564"(npBAF complex)|go:"GO:0071565"(nBAF complex)|interpro:IPR000330(SNF2-related)|interpro:IPR001487(Bromodomain)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006576(BRK)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014012(Helicase/SANT-associated, DNA binding)|interpro:IPR014978(QLQ)|interpro:IPR018359|interpro:IPR027417|interpro:IPR029295|interpro:IPR030088|interpro:IPR036427|interpro:IPR037259|interpro:IPR038718|mint:P51531|rcsb pdb:2DAT|rcsb pdb:4QY4|rcsb pdb:5DKC|rcsb pdb:5DKH|rcsb pdb:6EG2|rcsb pdb:6EG3|rcsb pdb:6HAX|rcsb pdb:6HAY|rcsb pdb:6HAZ|reactome:R-HSA-3214858|reactome:R-HSA-8939243	refseq:NP_006452.3|ensembl:ENSP00000323300|ensembl:ENSG00000076382(gene)|ensembl:ENST00000321765(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000776"(kinetochore)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007051"(spindle organization)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008017"(microtubule binding)|go:"GO:0016604"(nuclear body)|go:"GO:0030496"(midbody)|go:"GO:0032388"(positive regulation of intracellular transport)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035253"(ciliary rootlet)|go:"GO:0035371"(microtubule plus-end)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051294"(establishment of spindle orientation)|go:"GO:0051301"(cell division)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090235"(regulation of metaphase plate congression)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:1905832"(positive regulation of spindle assembly)|interpro:IPR028728|mint:Q96R06|dip:DIP-30998N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:DmQot4h4SmtqmUGBgF5ictTah289606	rogid:WOMksaINKpqSxqeGIzbmcSRcgdw9606	rigid:vdQnzBPgU3btyXCXkARCpE6BkTE	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51531	uniprotkb:Q8TAQ2	intact:EBI-679562|uniprotkb:B1ALG3|uniprotkb:B1ALG4|uniprotkb:D3DRH4|uniprotkb:D3DRH5|ensembl:ENSP00000265773|ensembl:ENSP00000371638	intact:EBI-357418|ensembl:ENSP00000267064|uniprotkb:Q92923|uniprotkb:Q96E12|uniprotkb:Q96GY4|intact:EBI-1759986|intact:EBI-1965079|uniprotkb:F8VTJ5|uniprotkb:Q59GV3	psi-mi:smca2_human(display_long)|uniprotkb:ATP-dependent helicase SMARCA2(gene name synonym)|uniprotkb:SNF2-alpha(gene name synonym)|uniprotkb:SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2(gene name synonym)|uniprotkb:SMARCA2(gene name)|psi-mi:SMARCA2(display_short)|uniprotkb:BRM(gene name synonym)|uniprotkb:SNF2A(gene name synonym)|uniprotkb:SNF2L2(gene name synonym)|uniprotkb:BAF190B(gene name synonym)|uniprotkb:Protein brahma homolog(gene name synonym)|uniprotkb:BRG1-associated factor 190B(gene name synonym)	psi-mi:smrc2_human(display_long)|uniprotkb:SMARCC2(gene name)|psi-mi:SMARCC2(display_short)|uniprotkb:BAF170(gene name synonym)|uniprotkb:SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2(gene name synonym)|uniprotkb:SWI/SNF complex 170 kDa subunit(gene name synonym)|uniprotkb:BRG1-associated factor 170(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515337|imex:IM-28561-1411	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003061.3|refseq:NP_620614.2|refseq:NP_001276325.1|refseq:NP_001276326.1|dip:DIP-29005N|ensembl:ENSG00000080503(gene)|ensembl:ENST00000349721(transcript)|ensembl:ENST00000382203(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007286"(spermatid development)|go:"GO:0007399"(nervous system development)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0042393"(histone binding)|go:"GO:0043044"|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070615"|go:"GO:0071564"(npBAF complex)|go:"GO:0071565"(nBAF complex)|interpro:IPR000330(SNF2-related)|interpro:IPR001487(Bromodomain)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006576(BRK)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014012(Helicase/SANT-associated, DNA binding)|interpro:IPR014978(QLQ)|interpro:IPR018359|interpro:IPR027417|interpro:IPR029295|interpro:IPR030088|interpro:IPR036427|interpro:IPR037259|interpro:IPR038718|mint:P51531|rcsb pdb:2DAT|rcsb pdb:4QY4|rcsb pdb:5DKC|rcsb pdb:5DKH|rcsb pdb:6EG2|rcsb pdb:6EG3|rcsb pdb:6HAX|rcsb pdb:6HAY|rcsb pdb:6HAZ|reactome:R-HSA-3214858|reactome:R-HSA-8939243	ensembl:ENSG00000139613(gene)|ensembl:ENST00000267064(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006337"(nucleosome disassembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042393"(histone binding)|go:"GO:0043044"|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071564"(npBAF complex)|go:"GO:0071565"(nBAF complex)|interpro:IPR000953(Chromo domain)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR007526(SWIRM)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017884|interpro:IPR017930|interpro:IPR032448|interpro:IPR032450|interpro:IPR032451|interpro:IPR036388|interpro:IPR036420|interpro:IPR038044|mint:Q8TAQ2|rcsb pdb:6KAG|rcsb pdb:6LTH|rcsb pdb:6LTJ|reactome:R-HSA-3214858|reactome:R-HSA-8939243|refseq:NP_003066.2|refseq:NP_001123892.1|refseq:NP_620706.1|refseq:NP_001317217.1|dip:DIP-27611N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:DmQot4h4SmtqmUGBgF5ictTah289606	rogid:60gIB3J1YI/FzqVCzdoSg1Oj3ME9606	rigid:8enYUPIGsaUPkz956XiHtjHGTDU	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51531	uniprotkb:Q9BZL4	intact:EBI-679562|uniprotkb:B1ALG3|uniprotkb:B1ALG4|uniprotkb:D3DRH4|uniprotkb:D3DRH5|ensembl:ENSP00000265773|ensembl:ENSP00000371638	intact:EBI-721802|uniprotkb:Q59FK8|uniprotkb:Q6ZPD1|uniprotkb:Q7L8F7|uniprotkb:Q9H5H5|uniprotkb:Q9NT00|uniprotkb:Q96HW1|uniprotkb:B4DME2|ensembl:ENSP00000263433	psi-mi:smca2_human(display_long)|uniprotkb:ATP-dependent helicase SMARCA2(gene name synonym)|uniprotkb:SNF2-alpha(gene name synonym)|uniprotkb:SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2(gene name synonym)|uniprotkb:SMARCA2(gene name)|psi-mi:SMARCA2(display_short)|uniprotkb:BRM(gene name synonym)|uniprotkb:SNF2A(gene name synonym)|uniprotkb:SNF2L2(gene name synonym)|uniprotkb:BAF190B(gene name synonym)|uniprotkb:Protein brahma homolog(gene name synonym)|uniprotkb:BRG1-associated factor 190B(gene name synonym)	psi-mi:pp12c_human(display_long)|uniprotkb:LENG3(gene name synonym)|uniprotkb:MBS85(gene name synonym)|uniprotkb:Protein phosphatase 1 myosin-binding subunit of 85 kDa(gene name synonym)|uniprotkb:PPP1R12C(gene name)|psi-mi:PPP1R12C(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515330|imex:IM-28561-269	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003061.3|refseq:NP_620614.2|refseq:NP_001276325.1|refseq:NP_001276326.1|dip:DIP-29005N|ensembl:ENSG00000080503(gene)|ensembl:ENST00000349721(transcript)|ensembl:ENST00000382203(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007286"(spermatid development)|go:"GO:0007399"(nervous system development)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0042393"(histone binding)|go:"GO:0043044"|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070615"|go:"GO:0071564"(npBAF complex)|go:"GO:0071565"(nBAF complex)|interpro:IPR000330(SNF2-related)|interpro:IPR001487(Bromodomain)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006576(BRK)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014012(Helicase/SANT-associated, DNA binding)|interpro:IPR014978(QLQ)|interpro:IPR018359|interpro:IPR027417|interpro:IPR029295|interpro:IPR030088|interpro:IPR036427|interpro:IPR037259|interpro:IPR038718|mint:P51531|rcsb pdb:2DAT|rcsb pdb:4QY4|rcsb pdb:5DKC|rcsb pdb:5DKH|rcsb pdb:6EG2|rcsb pdb:6EG3|rcsb pdb:6HAX|rcsb pdb:6HAY|rcsb pdb:6HAZ|reactome:R-HSA-3214858|reactome:R-HSA-8939243	refseq:NP_060077.1|refseq:NP_001258547.1|refseq:XP_005259070.1|ensembl:ENSG00000125503(gene)|ensembl:ENST00000263433(transcript)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007165"(signal transduction)|go:"GO:0019208"(phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|interpro:IPR002110(Ankyrin)|interpro:IPR017401(Protein phosphatase 1, regulatory subunits 12A/B/C, eukaryote)|interpro:IPR020683|interpro:IPR031205|interpro:IPR031775|interpro:IPR036770|mint:Q9BZL4	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:DmQot4h4SmtqmUGBgF5ictTah289606	rogid:q24mbt02IydCWtQyNXmNVWav/i89606	rigid:KkYy+9W+BqCwxKp/UmDAv+3z/AM	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51531	uniprotkb:O75334	intact:EBI-679562|uniprotkb:B1ALG3|uniprotkb:B1ALG4|uniprotkb:D3DRH4|uniprotkb:D3DRH5|ensembl:ENSP00000265773|ensembl:ENSP00000371638	intact:EBI-1105129|ensembl:ENSP00000450337|uniprotkb:B3KXA0|uniprotkb:B7ZKZ5|uniprotkb:F8VP68|uniprotkb:Q2M3G8|uniprotkb:B3KVT5|uniprotkb:B7Z2A6|uniprotkb:B7Z3U9|uniprotkb:B7Z663|uniprotkb:E7ERB8|uniprotkb:E7ETG6	psi-mi:smca2_human(display_long)|uniprotkb:ATP-dependent helicase SMARCA2(gene name synonym)|uniprotkb:SNF2-alpha(gene name synonym)|uniprotkb:SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2(gene name synonym)|uniprotkb:SMARCA2(gene name)|psi-mi:SMARCA2(display_short)|uniprotkb:BRM(gene name synonym)|uniprotkb:SNF2A(gene name synonym)|uniprotkb:SNF2L2(gene name synonym)|uniprotkb:BAF190B(gene name synonym)|uniprotkb:Protein brahma homolog(gene name synonym)|uniprotkb:BRG1-associated factor 190B(gene name synonym)	psi-mi:lipa2_human(display_long)|uniprotkb:PPFIA2(gene name)|psi-mi:PPFIA2(display_short)|uniprotkb:Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-2(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515323|imex:IM-28561-1409	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003061.3|refseq:NP_620614.2|refseq:NP_001276325.1|refseq:NP_001276326.1|dip:DIP-29005N|ensembl:ENSG00000080503(gene)|ensembl:ENST00000349721(transcript)|ensembl:ENST00000382203(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007286"(spermatid development)|go:"GO:0007399"(nervous system development)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0042393"(histone binding)|go:"GO:0043044"|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070615"|go:"GO:0071564"(npBAF complex)|go:"GO:0071565"(nBAF complex)|interpro:IPR000330(SNF2-related)|interpro:IPR001487(Bromodomain)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006576(BRK)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014012(Helicase/SANT-associated, DNA binding)|interpro:IPR014978(QLQ)|interpro:IPR018359|interpro:IPR027417|interpro:IPR029295|interpro:IPR030088|interpro:IPR036427|interpro:IPR037259|interpro:IPR038718|mint:P51531|rcsb pdb:2DAT|rcsb pdb:4QY4|rcsb pdb:5DKC|rcsb pdb:5DKH|rcsb pdb:6EG2|rcsb pdb:6EG3|rcsb pdb:6HAX|rcsb pdb:6HAY|rcsb pdb:6HAZ|reactome:R-HSA-3214858|reactome:R-HSA-8939243	refseq:NP_003616.2|ensembl:ENSG00000139220(gene)|ensembl:ENST00000549396(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0009986"(cell surface)|go:"GO:0030424"(axon)|go:"GO:0043197"(dendritic spine)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050808"(synapse organization)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099181"(structural constituent of presynapse)|go:"GO:0099519"(dense core granule cytoskeletal transport)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR029515|interpro:IPR030441|interpro:IPR037620|interpro:IPR037621|interpro:IPR037622|mint:O75334|rcsb pdb:3TAC|rcsb pdb:3TAD|rcsb pdb:6IUH|rcsb pdb:7D2E|rcsb pdb:7D2G|rcsb pdb:7D2H|reactome:R-HSA-181429|reactome:R-HSA-181430|reactome:R-HSA-210500|reactome:R-HSA-212676|reactome:R-HSA-264642|reactome:R-HSA-388844|refseq:NP_001207403.1|refseq:NP_001207404.1|refseq:NP_001207405.1|refseq:NP_001207406.1|refseq:NP_001207407.1|refseq:NP_001207408.1|refseq:NP_001207409.1|refseq:XP_016875569.1|refseq:XP_016875571.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:DmQot4h4SmtqmUGBgF5ictTah289606	rogid:JWcUe5GLHo/JyakmiC91TuspElU9606	rigid:EMikAgOUPqe27JAef3aNePgSQ6M	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51531	uniprotkb:Q9NRD5	intact:EBI-679562|uniprotkb:B1ALG3|uniprotkb:B1ALG4|uniprotkb:D3DRH4|uniprotkb:D3DRH5|ensembl:ENSP00000265773|ensembl:ENSP00000371638	intact:EBI-79165|uniprotkb:O95906|ensembl:ENSP00000349465|ensembl:ENSP00000385205|intact:EBI-2622151|uniprotkb:B3KS52	psi-mi:smca2_human(display_long)|uniprotkb:ATP-dependent helicase SMARCA2(gene name synonym)|uniprotkb:SNF2-alpha(gene name synonym)|uniprotkb:SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2(gene name synonym)|uniprotkb:SMARCA2(gene name)|psi-mi:SMARCA2(display_short)|uniprotkb:BRM(gene name synonym)|uniprotkb:SNF2A(gene name synonym)|uniprotkb:SNF2L2(gene name synonym)|uniprotkb:BAF190B(gene name synonym)|uniprotkb:Protein brahma homolog(gene name synonym)|uniprotkb:BRG1-associated factor 190B(gene name synonym)	psi-mi:pick1_human(display_long)|uniprotkb:PICK1(gene name)|psi-mi:PICK1(display_short)|uniprotkb:PRKCABP(gene name synonym)|uniprotkb:Protein kinase C-alpha-binding protein(gene name synonym)|uniprotkb:Protein interacting with C kinase 1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515316|imex:IM-28561-73	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003061.3|refseq:NP_620614.2|refseq:NP_001276325.1|refseq:NP_001276326.1|dip:DIP-29005N|ensembl:ENSG00000080503(gene)|ensembl:ENST00000349721(transcript)|ensembl:ENST00000382203(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007286"(spermatid development)|go:"GO:0007399"(nervous system development)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0042393"(histone binding)|go:"GO:0043044"|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070615"|go:"GO:0071564"(npBAF complex)|go:"GO:0071565"(nBAF complex)|interpro:IPR000330(SNF2-related)|interpro:IPR001487(Bromodomain)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006576(BRK)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014012(Helicase/SANT-associated, DNA binding)|interpro:IPR014978(QLQ)|interpro:IPR018359|interpro:IPR027417|interpro:IPR029295|interpro:IPR030088|interpro:IPR036427|interpro:IPR037259|interpro:IPR038718|mint:P51531|rcsb pdb:2DAT|rcsb pdb:4QY4|rcsb pdb:5DKC|rcsb pdb:5DKH|rcsb pdb:6EG2|rcsb pdb:6EG3|rcsb pdb:6HAX|rcsb pdb:6HAY|rcsb pdb:6HAZ|reactome:R-HSA-3214858|reactome:R-HSA-8939243	ensembl:ENSG00000100151(gene)|ensembl:ENST00000356976(transcript)|ensembl:ENST00000404072(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|refseq:NP_001034672.1|refseq:NP_001034673.1|refseq:NP_036539.1|go:"GO:0015844"(monoamine transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021782"(glial cell development)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0034315"(regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0034316"(negative regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0036294"(cellular response to decreased oxygen levels)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0043113"(receptor clustering)|go:"GO:0045161"(neuronal ion channel clustering)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051015"(actin filament binding)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0098842"(postsynaptic early endosome)|go:"GO:0140090"(membrane curvature sensor activity)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR010504(Arfaptin-like)|interpro:IPR027267|interpro:IPR030798|interpro:IPR036034|interpro:IPR037959|mint:Q9NRD5|rcsb pdb:2GZV|rcsb pdb:6AR4|rcsb pdb:6BJN|rcsb pdb:6BJO|reactome:R-HSA-202733|reactome:R-HSA-416993	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:DmQot4h4SmtqmUGBgF5ictTah289606	rogid:qRx+eNG7We8Oe0SQOekqpJpn8zk9606	rigid:Ak23PepjBRasZnLOxjeRG2e6H20	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51531	uniprotkb:P37198	intact:EBI-679562|uniprotkb:B1ALG3|uniprotkb:B1ALG4|uniprotkb:D3DRH4|uniprotkb:D3DRH5|ensembl:ENSP00000265773|ensembl:ENSP00000371638	intact:EBI-347978|intact:EBI-28983799|ensembl:ENSP00000305503|ensembl:ENSP00000407331|ensembl:ENSP00000471191|ensembl:ENSP00000473192|uniprotkb:Q6GTM2|uniprotkb:Q503A4|uniprotkb:Q96C43|uniprotkb:Q9NSL1|uniprotkb:B3KWU5	psi-mi:smca2_human(display_long)|uniprotkb:ATP-dependent helicase SMARCA2(gene name synonym)|uniprotkb:SNF2-alpha(gene name synonym)|uniprotkb:SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2(gene name synonym)|uniprotkb:SMARCA2(gene name)|psi-mi:SMARCA2(display_short)|uniprotkb:BRM(gene name synonym)|uniprotkb:SNF2A(gene name synonym)|uniprotkb:SNF2L2(gene name synonym)|uniprotkb:BAF190B(gene name synonym)|uniprotkb:Protein brahma homolog(gene name synonym)|uniprotkb:BRG1-associated factor 190B(gene name synonym)	psi-mi:nup62_human(display_long)|uniprotkb:NUP62(gene name)|psi-mi:NUP62(display_short)|uniprotkb:62 kDa nucleoporin(gene name synonym)|uniprotkb:Nucleoporin Nup62(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515309|imex:IM-28561-1407	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003061.3|refseq:NP_620614.2|refseq:NP_001276325.1|refseq:NP_001276326.1|dip:DIP-29005N|ensembl:ENSG00000080503(gene)|ensembl:ENST00000349721(transcript)|ensembl:ENST00000382203(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007286"(spermatid development)|go:"GO:0007399"(nervous system development)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0042393"(histone binding)|go:"GO:0043044"|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070615"|go:"GO:0071564"(npBAF complex)|go:"GO:0071565"(nBAF complex)|interpro:IPR000330(SNF2-related)|interpro:IPR001487(Bromodomain)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006576(BRK)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014012(Helicase/SANT-associated, DNA binding)|interpro:IPR014978(QLQ)|interpro:IPR018359|interpro:IPR027417|interpro:IPR029295|interpro:IPR030088|interpro:IPR036427|interpro:IPR037259|interpro:IPR038718|mint:P51531|rcsb pdb:2DAT|rcsb pdb:4QY4|rcsb pdb:5DKC|rcsb pdb:5DKH|rcsb pdb:6EG2|rcsb pdb:6EG3|rcsb pdb:6HAX|rcsb pdb:6HAY|rcsb pdb:6HAZ|reactome:R-HSA-3214858|reactome:R-HSA-8939243	refseq:NP_714941.1|ensembl:ENSG00000213024(gene)|ensembl:ENST00000352066(transcript)|ensembl:ENST00000422090(transcript)|ensembl:ENST00000596217(transcript)|ensembl:ENST00000597029(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005642"(annulate lamellae)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006405"(RNA export from nucleus)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007100"(mitotic centrosome separation)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007569"(cell aging)|go:"GO:0008219"(cell death)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0003682"(chromatin binding)|go:"GO:0017056"(structural constituent of nuclear pore)|go:"GO:0019894"(kinesin binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042306"(regulation of protein import into nucleus)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0044613"(nuclear pore central transport channel)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046578"(regulation of Ras protein signal transduction)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0046601"(positive regulation of centriole replication)|go:"GO:0051028"(mRNA transport)|go:"GO:0051425"(PTB domain binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0072686"(mitotic spindle)|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-6784531|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9615933|go:"GO:0090543"(Flemming body)|go:"GO:0098534"(centriole assembly)|go:"GO:1903438"(positive regulation of mitotic cytokinetic process)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR007758(Nucleoporin, Nsp1-like, C-terminal)|interpro:IPR026010|interpro:IPR033072|mint:P37198|rcsb pdb:2H4D|rcsb pdb:5IJN|rcsb pdb:5IJO|reactome:R-HSA-1169408|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|refseq:NP_714940.1|refseq:NP_001180286.1|refseq:NP_036478.2|refseq:NP_057637.2|ensembl:ENSP00000305503|ensembl:ENSP00000407331|ensembl:ENSP00000471191|ensembl:ENSP00000473192|dip:DIP-29749N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:DmQot4h4SmtqmUGBgF5ictTah289606	rogid:v7mvKvTtVEnLMwcpUZIcdAzge009606	rigid:o1itu485B9fmaca9NRCPgyHV+8o	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51531	uniprotkb:Q7Z6G3	intact:EBI-679562|uniprotkb:B1ALG3|uniprotkb:B1ALG4|uniprotkb:D3DRH4|uniprotkb:D3DRH5|ensembl:ENSP00000265773|ensembl:ENSP00000371638	intact:EBI-950070|ensembl:ENSP00000307449|uniprotkb:A2RRG3|uniprotkb:O75547|uniprotkb:Q6ZSK0|uniprotkb:H3BTW2	psi-mi:smca2_human(display_long)|uniprotkb:ATP-dependent helicase SMARCA2(gene name synonym)|uniprotkb:SNF2-alpha(gene name synonym)|uniprotkb:SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2(gene name synonym)|uniprotkb:SMARCA2(gene name)|psi-mi:SMARCA2(display_short)|uniprotkb:BRM(gene name synonym)|uniprotkb:SNF2A(gene name synonym)|uniprotkb:SNF2L2(gene name synonym)|uniprotkb:BAF190B(gene name synonym)|uniprotkb:Protein brahma homolog(gene name synonym)|uniprotkb:BRG1-associated factor 190B(gene name synonym)	psi-mi:neca2_human(display_long)|uniprotkb:Neuronal calcium-binding protein 2(gene name synonym)|uniprotkb:Synaptotagmin-interacting protein 2(gene name synonym)|uniprotkb:NECAB2(gene name)|psi-mi:NECAB2(display_short)|uniprotkb:EFCBP2(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515302|imex:IM-28561-71	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003061.3|refseq:NP_620614.2|refseq:NP_001276325.1|refseq:NP_001276326.1|dip:DIP-29005N|ensembl:ENSG00000080503(gene)|ensembl:ENST00000349721(transcript)|ensembl:ENST00000382203(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007286"(spermatid development)|go:"GO:0007399"(nervous system development)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0042393"(histone binding)|go:"GO:0043044"|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070615"|go:"GO:0071564"(npBAF complex)|go:"GO:0071565"(nBAF complex)|interpro:IPR000330(SNF2-related)|interpro:IPR001487(Bromodomain)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006576(BRK)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014012(Helicase/SANT-associated, DNA binding)|interpro:IPR014978(QLQ)|interpro:IPR018359|interpro:IPR027417|interpro:IPR029295|interpro:IPR030088|interpro:IPR036427|interpro:IPR037259|interpro:IPR038718|mint:P51531|rcsb pdb:2DAT|rcsb pdb:4QY4|rcsb pdb:5DKC|rcsb pdb:5DKH|rcsb pdb:6EG2|rcsb pdb:6EG3|rcsb pdb:6HAX|rcsb pdb:6HAY|rcsb pdb:6HAZ|reactome:R-HSA-3214858|reactome:R-HSA-8939243	ensembl:ENSG00000103154(gene)|ensembl:ENST00000305202(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031687"(A2A adenosine receptor binding)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042984"(regulation of amyloid precursor protein biosynthetic process)|go:"GO:0060168"(positive regulation of adenosine receptor signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1904021"(negative regulation of G protein-coupled receptor internalization)|go:"GO:1905477"(positive regulation of protein localization to membrane)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR007138(Antibiotic biosynthesis monooxygenase)|interpro:IPR011008(Dimeric alpha-beta barrel)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR039862|mint:Q7Z6G3|refseq:NP_061938.2|refseq:NP_001316678.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:DmQot4h4SmtqmUGBgF5ictTah289606	rogid:Op/JNOBupSCF1U3MCeNmJ6gUUrg9606	rigid:8b5q5lsXhVqVItItOLh8dsJ9anM	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51531	uniprotkb:Q9ULV0	intact:EBI-679562|uniprotkb:B1ALG3|uniprotkb:B1ALG4|uniprotkb:D3DRH4|uniprotkb:D3DRH5|ensembl:ENSP00000265773|ensembl:ENSP00000371638	intact:EBI-311356|uniprotkb:B0I1R3|uniprotkb:Q0P656|uniprotkb:Q9H6Y6|intact:EBI-28979562|ensembl:ENSP00000285039	psi-mi:smca2_human(display_long)|uniprotkb:ATP-dependent helicase SMARCA2(gene name synonym)|uniprotkb:SNF2-alpha(gene name synonym)|uniprotkb:SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2(gene name synonym)|uniprotkb:SMARCA2(gene name)|psi-mi:SMARCA2(display_short)|uniprotkb:BRM(gene name synonym)|uniprotkb:SNF2A(gene name synonym)|uniprotkb:SNF2L2(gene name synonym)|uniprotkb:BAF190B(gene name synonym)|uniprotkb:Protein brahma homolog(gene name synonym)|uniprotkb:BRG1-associated factor 190B(gene name synonym)	psi-mi:myo5b_human(display_long)|uniprotkb:MYO5B(gene name)|psi-mi:MYO5B(display_short)|uniprotkb:KIAA1119(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515295|imex:IM-28561-1405	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003061.3|refseq:NP_620614.2|refseq:NP_001276325.1|refseq:NP_001276326.1|dip:DIP-29005N|ensembl:ENSG00000080503(gene)|ensembl:ENST00000349721(transcript)|ensembl:ENST00000382203(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007286"(spermatid development)|go:"GO:0007399"(nervous system development)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0042393"(histone binding)|go:"GO:0043044"|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070615"|go:"GO:0071564"(npBAF complex)|go:"GO:0071565"(nBAF complex)|interpro:IPR000330(SNF2-related)|interpro:IPR001487(Bromodomain)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006576(BRK)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014012(Helicase/SANT-associated, DNA binding)|interpro:IPR014978(QLQ)|interpro:IPR018359|interpro:IPR027417|interpro:IPR029295|interpro:IPR030088|interpro:IPR036427|interpro:IPR037259|interpro:IPR038718|mint:P51531|rcsb pdb:2DAT|rcsb pdb:4QY4|rcsb pdb:5DKC|rcsb pdb:5DKH|rcsb pdb:6EG2|rcsb pdb:6EG3|rcsb pdb:6HAX|rcsb pdb:6HAY|rcsb pdb:6HAZ|reactome:R-HSA-3214858|reactome:R-HSA-8939243	ensembl:ENSP00000285039|ensembl:ENST00000592688|ensembl:ENSP00000466368|ensembl:ENSG00000167306(gene)|ensembl:ENST00000285039(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0003091"(renal water homeostasis)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007015"(actin filament organization)|go:"GO:0015031"(protein transport)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0016459"(myosin complex)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031982"(vesicle)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045179"(apical cortex)|go:"GO:0051015"(actin filament binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR002710(Dilute)|interpro:IPR004009(Myosin, N-terminal, SH3-like)|interpro:IPR027417|interpro:IPR036103|interpro:IPR036961|interpro:IPR037990|mint:Q9ULV0|rcsb pdb:4J5M|rcsb pdb:4LNZ|rcsb pdb:4LWZ|rcsb pdb:4LX0|reactome:R-HSA-432040|refseq:NP_001073936.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:DmQot4h4SmtqmUGBgF5ictTah289606	rogid:p6fM9FBgui27LRlshWAjPe47Ftc9606	rigid:bRCubyZnCh8pZllccMfutxnnZMw	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51531	uniprotkb:Q6WCQ1	intact:EBI-679562|uniprotkb:B1ALG3|uniprotkb:B1ALG4|uniprotkb:D3DRH4|uniprotkb:D3DRH5|ensembl:ENSP00000265773|ensembl:ENSP00000371638	intact:EBI-1022605|uniprotkb:Q3KQZ5|uniprotkb:Q5FB94|uniprotkb:Q6DHW2|uniprotkb:Q7Z5Y2|uniprotkb:Q8N390|uniprotkb:Q96G40|ensembl:ENSP00000342379	psi-mi:smca2_human(display_long)|uniprotkb:ATP-dependent helicase SMARCA2(gene name synonym)|uniprotkb:SNF2-alpha(gene name synonym)|uniprotkb:SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2(gene name synonym)|uniprotkb:SMARCA2(gene name)|psi-mi:SMARCA2(display_short)|uniprotkb:BRM(gene name synonym)|uniprotkb:SNF2A(gene name synonym)|uniprotkb:SNF2L2(gene name synonym)|uniprotkb:BAF190B(gene name synonym)|uniprotkb:Protein brahma homolog(gene name synonym)|uniprotkb:BRG1-associated factor 190B(gene name synonym)	psi-mi:mprip_human(display_long)|uniprotkb:MRIP(gene name synonym)|uniprotkb:Rho-interacting protein 3(gene name synonym)|uniprotkb:p116Rip(gene name synonym)|uniprotkb:MPRIP(gene name)|psi-mi:MPRIP(display_short)|uniprotkb:KIAA0864(gene name synonym)|uniprotkb:RHOIP3(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515288|imex:IM-28561-483	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003061.3|refseq:NP_620614.2|refseq:NP_001276325.1|refseq:NP_001276326.1|dip:DIP-29005N|ensembl:ENSG00000080503(gene)|ensembl:ENST00000349721(transcript)|ensembl:ENST00000382203(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007286"(spermatid development)|go:"GO:0007399"(nervous system development)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0042393"(histone binding)|go:"GO:0043044"|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070615"|go:"GO:0071564"(npBAF complex)|go:"GO:0071565"(nBAF complex)|interpro:IPR000330(SNF2-related)|interpro:IPR001487(Bromodomain)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006576(BRK)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014012(Helicase/SANT-associated, DNA binding)|interpro:IPR014978(QLQ)|interpro:IPR018359|interpro:IPR027417|interpro:IPR029295|interpro:IPR030088|interpro:IPR036427|interpro:IPR037259|interpro:IPR038718|mint:P51531|rcsb pdb:2DAT|rcsb pdb:4QY4|rcsb pdb:5DKC|rcsb pdb:5DKH|rcsb pdb:6EG2|rcsb pdb:6EG3|rcsb pdb:6HAX|rcsb pdb:6HAY|rcsb pdb:6HAZ|reactome:R-HSA-3214858|reactome:R-HSA-8939243	ensembl:ENSG00000133030(gene)|ensembl:ENST00000341712(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0045296"(cadherin binding)|go:"GO:0051015"(actin filament binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039597|mint:Q6WCQ1|reactome:R-HSA-6802952|refseq:NP_055949.2|refseq:NP_958431.2	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:DmQot4h4SmtqmUGBgF5ictTah289606	rogid:QoGbbg2ehuQogDM1Dlxzw6xj59s9606	rigid:UhO2ulqJfTpc0yMMsK6uMfw9IJ8	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51531	uniprotkb:A4QMR6	intact:EBI-679562|uniprotkb:B1ALG3|uniprotkb:B1ALG4|uniprotkb:D3DRH4|uniprotkb:D3DRH5|ensembl:ENSP00000265773|ensembl:ENSP00000371638	intact:EBI-26512834	psi-mi:smca2_human(display_long)|uniprotkb:ATP-dependent helicase SMARCA2(gene name synonym)|uniprotkb:SNF2-alpha(gene name synonym)|uniprotkb:SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2(gene name synonym)|uniprotkb:SMARCA2(gene name)|psi-mi:SMARCA2(display_short)|uniprotkb:BRM(gene name synonym)|uniprotkb:SNF2A(gene name synonym)|uniprotkb:SNF2L2(gene name synonym)|uniprotkb:BAF190B(gene name synonym)|uniprotkb:Protein brahma homolog(gene name synonym)|uniprotkb:BRG1-associated factor 190B(gene name synonym)	psi-mi:a4qmr6_human(display_long)|uniprotkb:LOC161527(gene name)|psi-mi:LOC161527(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515281|imex:IM-28561-931	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003061.3|refseq:NP_620614.2|refseq:NP_001276325.1|refseq:NP_001276326.1|dip:DIP-29005N|ensembl:ENSG00000080503(gene)|ensembl:ENST00000349721(transcript)|ensembl:ENST00000382203(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007286"(spermatid development)|go:"GO:0007399"(nervous system development)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0042393"(histone binding)|go:"GO:0043044"|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070615"|go:"GO:0071564"(npBAF complex)|go:"GO:0071565"(nBAF complex)|interpro:IPR000330(SNF2-related)|interpro:IPR001487(Bromodomain)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006576(BRK)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014012(Helicase/SANT-associated, DNA binding)|interpro:IPR014978(QLQ)|interpro:IPR018359|interpro:IPR027417|interpro:IPR029295|interpro:IPR030088|interpro:IPR036427|interpro:IPR037259|interpro:IPR038718|mint:P51531|rcsb pdb:2DAT|rcsb pdb:4QY4|rcsb pdb:5DKC|rcsb pdb:5DKH|rcsb pdb:6EG2|rcsb pdb:6EG3|rcsb pdb:6HAX|rcsb pdb:6HAY|rcsb pdb:6HAZ|reactome:R-HSA-3214858|reactome:R-HSA-8939243	mint:A4QMR6|interpro:IPR026737	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:DmQot4h4SmtqmUGBgF5ictTah289606	rogid:KvNuZ8rcDl4zQK2F9RHcXD4oHGQ9606	rigid:j9DnUSTOeAhvTUfnyUuHDfEUxw0	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51531	uniprotkb:P11047	intact:EBI-679562|uniprotkb:B1ALG3|uniprotkb:B1ALG4|uniprotkb:D3DRH4|uniprotkb:D3DRH5|ensembl:ENSP00000265773|ensembl:ENSP00000371638	intact:EBI-714904|uniprotkb:Q5VYE7|ensembl:ENSP00000258341	psi-mi:smca2_human(display_long)|uniprotkb:ATP-dependent helicase SMARCA2(gene name synonym)|uniprotkb:SNF2-alpha(gene name synonym)|uniprotkb:SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2(gene name synonym)|uniprotkb:SMARCA2(gene name)|psi-mi:SMARCA2(display_short)|uniprotkb:BRM(gene name synonym)|uniprotkb:SNF2A(gene name synonym)|uniprotkb:SNF2L2(gene name synonym)|uniprotkb:BAF190B(gene name synonym)|uniprotkb:Protein brahma homolog(gene name synonym)|uniprotkb:BRG1-associated factor 190B(gene name synonym)	psi-mi:lamc1_human(display_long)|uniprotkb:Laminin B2 chain(gene name synonym)|uniprotkb:LAMC1(gene name)|psi-mi:LAMC1(display_short)|uniprotkb:LAMB2(gene name synonym)|uniprotkb:Laminin-1 subunit gamma(gene name synonym)|uniprotkb:Laminin-2 subunit gamma(gene name synonym)|uniprotkb:Laminin-3 subunit gamma(gene name synonym)|uniprotkb:Laminin-4 subunit gamma(gene name synonym)|uniprotkb:Laminin-6 subunit gamma(gene name synonym)|uniprotkb:Laminin-7 subunit gamma(gene name synonym)|uniprotkb:Laminin-8 subunit gamma(gene name synonym)|uniprotkb:Laminin-9 subunit gamma(gene name synonym)|uniprotkb:Laminin-10 subunit gamma(gene name synonym)|uniprotkb:Laminin-11 subunit gamma(gene name synonym)|uniprotkb:S-laminin subunit gamma(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515274|imex:IM-28561-267	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003061.3|refseq:NP_620614.2|refseq:NP_001276325.1|refseq:NP_001276326.1|dip:DIP-29005N|ensembl:ENSG00000080503(gene)|ensembl:ENST00000349721(transcript)|ensembl:ENST00000382203(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007286"(spermatid development)|go:"GO:0007399"(nervous system development)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0042393"(histone binding)|go:"GO:0043044"|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070615"|go:"GO:0071564"(npBAF complex)|go:"GO:0071565"(nBAF complex)|interpro:IPR000330(SNF2-related)|interpro:IPR001487(Bromodomain)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006576(BRK)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014012(Helicase/SANT-associated, DNA binding)|interpro:IPR014978(QLQ)|interpro:IPR018359|interpro:IPR027417|interpro:IPR029295|interpro:IPR030088|interpro:IPR036427|interpro:IPR037259|interpro:IPR038718|mint:P51531|rcsb pdb:2DAT|rcsb pdb:4QY4|rcsb pdb:5DKC|rcsb pdb:5DKH|rcsb pdb:6EG2|rcsb pdb:6EG3|rcsb pdb:6HAX|rcsb pdb:6HAY|rcsb pdb:6HAZ|reactome:R-HSA-3214858|reactome:R-HSA-8939243	interpro:IPR000034(Laminin B)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002049(EGF-like, laminin)|interpro:IPR008211(Laminin, N-terminal)|mint:P11047|rcsb pdb:5XAU|rcsb pdb:7CEC|reactome:R-HSA-1474228|reactome:R-HSA-3000157|reactome:R-HSA-3000171|reactome:R-HSA-3000178|reactome:R-HSA-373760|reactome:R-HSA-381426|reactome:R-HSA-8874081|reactome:R-HSA-8957275|reactome:R-HSA-9619665|go:"GO:0070062"(extracellular exosome)|refseq:NP_002284.3|ensembl:ENSG00000135862(gene)|ensembl:ENST00000258341(transcript)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005606"(laminin-1 complex)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0007155"(cell adhesion)|go:"GO:0007492"(endoderm development)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009888"(tissue development)|go:"GO:0016477"(cell migration)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0031581"(hemidesmosome assembly)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0043259"(laminin-10 complex)|go:"GO:0043260"(laminin-11 complex)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0065003"(protein-containing complex assembly)	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:DmQot4h4SmtqmUGBgF5ictTah289606	rogid:2JMPODzaiqmTaLlmjdgvlv8e8+M9606	rigid:8z21TlAinLWwjjUdqB37d6oyX48	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51531	uniprotkb:P14136	intact:EBI-679562|uniprotkb:B1ALG3|uniprotkb:B1ALG4|uniprotkb:D3DRH4|uniprotkb:D3DRH5|ensembl:ENSP00000265773|ensembl:ENSP00000371638	intact:EBI-744302|uniprotkb:Q53H98|uniprotkb:Q5D055|uniprotkb:Q6ZQS3|uniprotkb:Q7Z5J6|uniprotkb:Q7Z5J7|uniprotkb:Q96KS4|uniprotkb:Q96P18|uniprotkb:Q9UFD0|uniprotkb:B2RD44|uniprotkb:D3DX59|intact:EBI-3909365|uniprotkb:E9PAX3|ensembl:ENSP00000466598|uniprotkb:A7REI1	psi-mi:smca2_human(display_long)|uniprotkb:ATP-dependent helicase SMARCA2(gene name synonym)|uniprotkb:SNF2-alpha(gene name synonym)|uniprotkb:SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2(gene name synonym)|uniprotkb:SMARCA2(gene name)|psi-mi:SMARCA2(display_short)|uniprotkb:BRM(gene name synonym)|uniprotkb:SNF2A(gene name synonym)|uniprotkb:SNF2L2(gene name synonym)|uniprotkb:BAF190B(gene name synonym)|uniprotkb:Protein brahma homolog(gene name synonym)|uniprotkb:BRG1-associated factor 190B(gene name synonym)	psi-mi:gfap_human(display_long)|uniprotkb:GFAP(gene name)|psi-mi:GFAP(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515267|imex:IM-28561-1633	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003061.3|refseq:NP_620614.2|refseq:NP_001276325.1|refseq:NP_001276326.1|dip:DIP-29005N|ensembl:ENSG00000080503(gene)|ensembl:ENST00000349721(transcript)|ensembl:ENST00000382203(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007286"(spermatid development)|go:"GO:0007399"(nervous system development)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0042393"(histone binding)|go:"GO:0043044"|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070615"|go:"GO:0071564"(npBAF complex)|go:"GO:0071565"(nBAF complex)|interpro:IPR000330(SNF2-related)|interpro:IPR001487(Bromodomain)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006576(BRK)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014012(Helicase/SANT-associated, DNA binding)|interpro:IPR014978(QLQ)|interpro:IPR018359|interpro:IPR027417|interpro:IPR029295|interpro:IPR030088|interpro:IPR036427|interpro:IPR037259|interpro:IPR038718|mint:P51531|rcsb pdb:2DAT|rcsb pdb:4QY4|rcsb pdb:5DKC|rcsb pdb:5DKH|rcsb pdb:6EG2|rcsb pdb:6EG3|rcsb pdb:6HAX|rcsb pdb:6HAY|rcsb pdb:6HAZ|reactome:R-HSA-3214858|reactome:R-HSA-8939243	refseq:NP_001124491.1|refseq:NP_001229305.1|refseq:NP_002046.1|ensembl:ENSG00000131095(gene)|ensembl:ENST00000588735(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0009611"(response to wounding)|go:"GO:0010467"(gene expression)|go:"GO:0010625"(positive regulation of Schwann cell proliferation)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014002"(astrocyte development)|go:"GO:0019900"(kinase binding)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031102"(neuron projection regeneration)|go:"GO:0042802"(identical protein binding)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0044297"(cell body)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0051580"(regulation of neurotransmitter uptake)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0070779"(D-aspartate import across plasma membrane)|go:"GO:0097450"(astrocyte end-foot)|go:"GO:0098574"(cytoplasmic side of lysosomal membrane)|go:"GO:1904714"(regulation of chaperone-mediated autophagy)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|interpro:IPR027701|interpro:IPR039008|mint:P14136|rcsb pdb:6A9P|reactome:R-HSA-1251985|reactome:R-HSA-9613829	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:DmQot4h4SmtqmUGBgF5ictTah289606	rogid:Pz4JW0WjMjBYILTDSX9jUmMqWhg9606	rigid:KI+mlYFf66zhFPukT7mVBc5gtwM	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51531	uniprotkb:Q96CN9	intact:EBI-679562|uniprotkb:B1ALG3|uniprotkb:B1ALG4|uniprotkb:D3DRH4|uniprotkb:D3DRH5|ensembl:ENSP00000265773|ensembl:ENSP00000371638	intact:EBI-746252|uniprotkb:Q9H6N7|ensembl:ENSP00000318821	psi-mi:smca2_human(display_long)|uniprotkb:ATP-dependent helicase SMARCA2(gene name synonym)|uniprotkb:SNF2-alpha(gene name synonym)|uniprotkb:SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2(gene name synonym)|uniprotkb:SMARCA2(gene name)|psi-mi:SMARCA2(display_short)|uniprotkb:BRM(gene name synonym)|uniprotkb:SNF2A(gene name synonym)|uniprotkb:SNF2L2(gene name synonym)|uniprotkb:BAF190B(gene name synonym)|uniprotkb:Protein brahma homolog(gene name synonym)|uniprotkb:BRG1-associated factor 190B(gene name synonym)	psi-mi:gcc1_human(display_long)|uniprotkb:Golgi coiled-coil protein 1(gene name synonym)|uniprotkb:GCC1(gene name)|psi-mi:GCC1(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515260|imex:IM-28561-929	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003061.3|refseq:NP_620614.2|refseq:NP_001276325.1|refseq:NP_001276326.1|dip:DIP-29005N|ensembl:ENSG00000080503(gene)|ensembl:ENST00000349721(transcript)|ensembl:ENST00000382203(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007286"(spermatid development)|go:"GO:0007399"(nervous system development)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0042393"(histone binding)|go:"GO:0043044"|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070615"|go:"GO:0071564"(npBAF complex)|go:"GO:0071565"(nBAF complex)|interpro:IPR000330(SNF2-related)|interpro:IPR001487(Bromodomain)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006576(BRK)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014012(Helicase/SANT-associated, DNA binding)|interpro:IPR014978(QLQ)|interpro:IPR018359|interpro:IPR027417|interpro:IPR029295|interpro:IPR030088|interpro:IPR036427|interpro:IPR037259|interpro:IPR038718|mint:P51531|rcsb pdb:2DAT|rcsb pdb:4QY4|rcsb pdb:5DKC|rcsb pdb:5DKH|rcsb pdb:6EG2|rcsb pdb:6EG3|rcsb pdb:6HAX|rcsb pdb:6HAY|rcsb pdb:6HAZ|reactome:R-HSA-3214858|reactome:R-HSA-8939243	refseq:NP_078799.2|ensembl:ENSG00000179562(gene)|ensembl:ENST00000321407(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0031267"(small GTPase binding)|interpro:IPR000237(GRIP)|reactome:R-HSA-6811440|go:"GO:0000138"(Golgi trans cisterna)	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:DmQot4h4SmtqmUGBgF5ictTah289606	rogid:SCI+peKjPIvl/HbUUpHGM++qiRE9606	rigid:aylu2J/yt1GprEXMXUIsoGN/c3A	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51531	uniprotkb:P04406	intact:EBI-679562|uniprotkb:B1ALG3|uniprotkb:B1ALG4|uniprotkb:D3DRH4|uniprotkb:D3DRH5|ensembl:ENSP00000265773|ensembl:ENSP00000371638	intact:EBI-354056|uniprotkb:P00354|uniprotkb:Q53X65|uniprotkb:E7EUT4|ensembl:ENSP00000229239|ensembl:ENSP00000380068|ensembl:ENSP00000380070	psi-mi:smca2_human(display_long)|uniprotkb:ATP-dependent helicase SMARCA2(gene name synonym)|uniprotkb:SNF2-alpha(gene name synonym)|uniprotkb:SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2(gene name synonym)|uniprotkb:SMARCA2(gene name)|psi-mi:SMARCA2(display_short)|uniprotkb:BRM(gene name synonym)|uniprotkb:SNF2A(gene name synonym)|uniprotkb:SNF2L2(gene name synonym)|uniprotkb:BAF190B(gene name synonym)|uniprotkb:Protein brahma homolog(gene name synonym)|uniprotkb:BRG1-associated factor 190B(gene name synonym)	psi-mi:g3p_human(display_long)|uniprotkb:GAPDH(gene name)|psi-mi:GAPDH(display_short)|uniprotkb:OK/SW-cl.12(orf name)|uniprotkb:CDABP0047(orf name)|uniprotkb:GAPD(gene name synonym)|uniprotkb:Peptidyl-cysteine S-nitrosylase GAPDH(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515253|imex:IM-28561-69	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003061.3|refseq:NP_620614.2|refseq:NP_001276325.1|refseq:NP_001276326.1|dip:DIP-29005N|ensembl:ENSG00000080503(gene)|ensembl:ENST00000349721(transcript)|ensembl:ENST00000382203(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007286"(spermatid development)|go:"GO:0007399"(nervous system development)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0042393"(histone binding)|go:"GO:0043044"|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070615"|go:"GO:0071564"(npBAF complex)|go:"GO:0071565"(nBAF complex)|interpro:IPR000330(SNF2-related)|interpro:IPR001487(Bromodomain)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006576(BRK)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014012(Helicase/SANT-associated, DNA binding)|interpro:IPR014978(QLQ)|interpro:IPR018359|interpro:IPR027417|interpro:IPR029295|interpro:IPR030088|interpro:IPR036427|interpro:IPR037259|interpro:IPR038718|mint:P51531|rcsb pdb:2DAT|rcsb pdb:4QY4|rcsb pdb:5DKC|rcsb pdb:5DKH|rcsb pdb:6EG2|rcsb pdb:6EG3|rcsb pdb:6HAX|rcsb pdb:6HAY|rcsb pdb:6HAZ|reactome:R-HSA-3214858|reactome:R-HSA-8939243	refseq:NP_002037.2|refseq:NP_001243728.1|refseq:NP_001276674.1|refseq:NP_001276675.1|dip:DIP-32521N|go:"GO:0031965"(nuclear membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0035605"(peptidyl-cysteine S-nitrosylase activity)|go:"GO:0035606"(peptidyl-cysteine S-trans-nitrosylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050661"(NADP binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0050832"(defense response to fungus)|go:"GO:0051287"(NAD binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051873"(killing by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0097452"(GAIT complex)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR006424(Glyceraldehyde-3-phosphate dehydrogenase, type I)|interpro:IPR020828|interpro:IPR020829|interpro:IPR020830|interpro:IPR020831|interpro:IPR036291|mint:P04406|rcsb pdb:1U8F|rcsb pdb:1ZNQ|rcsb pdb:2FEH|rcsb pdb:3GPD|rcsb pdb:4WNC|rcsb pdb:4WNI|rcsb pdb:6ADE|rcsb pdb:6M61|rcsb pdb:6YND|rcsb pdb:6YNE|rcsb pdb:6YNF|rcsb pdb:6YNH|reactome:R-HSA-70171|reactome:R-HSA-70263|rcsb pdb:6IQ6|ensembl:ENSG00000111640(gene)|ensembl:ENST00000229239(transcript)|ensembl:ENST00000396859(transcript)|ensembl:ENST00000396861(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0004365"("glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0008017"(microtubule binding)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0031640"(killing of cells of another organism)	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:DmQot4h4SmtqmUGBgF5ictTah289606	rogid:9YENN/dfKl/d0tJtfFyQp2o8eAc9606	rigid:R2dPHnS/lAIonTXV0/bZbBIu2yA	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51531	uniprotkb:P50570	intact:EBI-679562|uniprotkb:B1ALG3|uniprotkb:B1ALG4|uniprotkb:D3DRH4|uniprotkb:D3DRH5|ensembl:ENSP00000265773|ensembl:ENSP00000371638	intact:EBI-346547|uniprotkb:Q7Z5S3|uniprotkb:Q5I0Y0|uniprotkb:Q9UPH4|intact:EBI-3959204|uniprotkb:A8K1B6|uniprotkb:E7EV30|uniprotkb:K7ESI9|intact:EBI-5912046|uniprotkb:E9PEQ4|ensembl:ENSP00000347890	psi-mi:smca2_human(display_long)|uniprotkb:ATP-dependent helicase SMARCA2(gene name synonym)|uniprotkb:SNF2-alpha(gene name synonym)|uniprotkb:SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2(gene name synonym)|uniprotkb:SMARCA2(gene name)|psi-mi:SMARCA2(display_short)|uniprotkb:BRM(gene name synonym)|uniprotkb:SNF2A(gene name synonym)|uniprotkb:SNF2L2(gene name synonym)|uniprotkb:BAF190B(gene name synonym)|uniprotkb:Protein brahma homolog(gene name synonym)|uniprotkb:BRG1-associated factor 190B(gene name synonym)	psi-mi:dyn2_human(display_long)|uniprotkb:DNM2(gene name)|psi-mi:DNM2(display_short)|uniprotkb:DYN2(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515246|imex:IM-28561-1403	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003061.3|refseq:NP_620614.2|refseq:NP_001276325.1|refseq:NP_001276326.1|dip:DIP-29005N|ensembl:ENSG00000080503(gene)|ensembl:ENST00000349721(transcript)|ensembl:ENST00000382203(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007286"(spermatid development)|go:"GO:0007399"(nervous system development)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0042393"(histone binding)|go:"GO:0043044"|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070615"|go:"GO:0071564"(npBAF complex)|go:"GO:0071565"(nBAF complex)|interpro:IPR000330(SNF2-related)|interpro:IPR001487(Bromodomain)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006576(BRK)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014012(Helicase/SANT-associated, DNA binding)|interpro:IPR014978(QLQ)|interpro:IPR018359|interpro:IPR027417|interpro:IPR029295|interpro:IPR030088|interpro:IPR036427|interpro:IPR037259|interpro:IPR038718|mint:P51531|rcsb pdb:2DAT|rcsb pdb:4QY4|rcsb pdb:5DKC|rcsb pdb:5DKH|rcsb pdb:6EG2|rcsb pdb:6EG3|rcsb pdb:6HAX|rcsb pdb:6HAY|rcsb pdb:6HAZ|reactome:R-HSA-3214858|reactome:R-HSA-8939243	refseq:NP_004936.2|refseq:NP_001005360.1|refseq:NP_001005361.1|refseq:NP_001005362.1|refseq:NP_001177645.1|dip:DIP-31244N|reactome:R-HSA-203641|reactome:R-HSA-2132295|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-437239|reactome:R-HSA-8856828|reactome:R-HSA-9031628|reactome:R-HSA-196025|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031749"(D2 dopamine receptor binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033572"(transferrin transport)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044351"(macropinocytosis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050699"(WW domain binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0061024"(membrane organization)|go:"GO:0061025"(membrane fusion)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071245"(cellular response to carbon monoxide)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0098793"(presynapse)|go:"GO:0098844"(postsynaptic endocytic zone membrane)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902856"(negative regulation of non-motile cilium assembly)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903358"(regulation of Golgi organization)|go:"GO:1903408"("positive regulation of P-type sodium:potassium-exchanging transporter activity")|go:"GO:1903526"(negative regulation of membrane tubulation)|go:"GO:2000370"(positive regulation of clathrin-dependent endocytosis)|interpro:IPR000375(Dynamin central region)|interpro:IPR001401(Dynamin, GTPase region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR003130(Dynamin GTPase effector)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019762|interpro:IPR020850|interpro:IPR022812|interpro:IPR027188|interpro:IPR027417|interpro:IPR030381|mint:P50570|rcsb pdb:2YS1|reactome:R-HSA-166016|reactome:R-HSA-177504|reactome:R-HSA-190873|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008017"(microtubule binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016185"(synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|ensembl:ENSG00000079805(gene)|ensembl:ENST00000355667(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0001891"(phagocytic cup)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0003374"(dynamin family protein polymerization involved in mitochondrial fission)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005925"(focal adhesion)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0006897"(endocytosis)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:DmQot4h4SmtqmUGBgF5ictTah289606	rogid:BAUEy6Iju72PTot46Xhz75cQTQs9606	rigid:AZ3PfQQHgqVguKcct3LTsjZFwaU	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51531	uniprotkb:Q5VWQ8	intact:EBI-679562|uniprotkb:B1ALG3|uniprotkb:B1ALG4|uniprotkb:D3DRH4|uniprotkb:D3DRH5|ensembl:ENSP00000265773|ensembl:ENSP00000371638	intact:EBI-2871881|uniprotkb:B0QZB1|uniprotkb:Q96SE1|uniprotkb:Q9C0C0|uniprotkb:A6H8V2|uniprotkb:A6NHI9|uniprotkb:Q8TDL2|uniprotkb:G3XA90|intact:EBI-28974929|ensembl:ENSP00000386183	psi-mi:smca2_human(display_long)|uniprotkb:ATP-dependent helicase SMARCA2(gene name synonym)|uniprotkb:SNF2-alpha(gene name synonym)|uniprotkb:SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2(gene name synonym)|uniprotkb:SMARCA2(gene name)|psi-mi:SMARCA2(display_short)|uniprotkb:BRM(gene name synonym)|uniprotkb:SNF2A(gene name synonym)|uniprotkb:SNF2L2(gene name synonym)|uniprotkb:BAF190B(gene name synonym)|uniprotkb:Protein brahma homolog(gene name synonym)|uniprotkb:BRG1-associated factor 190B(gene name synonym)	psi-mi:dab2p_human(display_long)|uniprotkb:DAB2IP(gene name)|psi-mi:DAB2IP(display_short)|uniprotkb:AF9Q34(gene name synonym)|uniprotkb:AIP1(gene name synonym)|uniprotkb:KIAA1743(gene name synonym)|uniprotkb:ASK-interacting protein 1(gene name synonym)|uniprotkb:DOC-2/DAB-2 interactive protein(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515239|imex:IM-28561-481	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003061.3|refseq:NP_620614.2|refseq:NP_001276325.1|refseq:NP_001276326.1|dip:DIP-29005N|ensembl:ENSG00000080503(gene)|ensembl:ENST00000349721(transcript)|ensembl:ENST00000382203(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007286"(spermatid development)|go:"GO:0007399"(nervous system development)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0042393"(histone binding)|go:"GO:0043044"|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070615"|go:"GO:0071564"(npBAF complex)|go:"GO:0071565"(nBAF complex)|interpro:IPR000330(SNF2-related)|interpro:IPR001487(Bromodomain)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006576(BRK)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014012(Helicase/SANT-associated, DNA binding)|interpro:IPR014978(QLQ)|interpro:IPR018359|interpro:IPR027417|interpro:IPR029295|interpro:IPR030088|interpro:IPR036427|interpro:IPR037259|interpro:IPR038718|mint:P51531|rcsb pdb:2DAT|rcsb pdb:4QY4|rcsb pdb:5DKC|rcsb pdb:5DKH|rcsb pdb:6EG2|rcsb pdb:6EG3|rcsb pdb:6HAX|rcsb pdb:6HAY|rcsb pdb:6HAZ|reactome:R-HSA-3214858|reactome:R-HSA-8939243	ensembl:ENST00000259371|ensembl:ENSP00000259371|ensembl:ENST00000309989|ensembl:ENSP00000310827|ensembl:ENSP00000386183|refseq:XP_011516572.1|refseq:XP_011516573.1|refseq:NP_115941.2|refseq:NP_619723.1|refseq:XP_016869789.1|refseq:XP_005251776.1|dip:DIP-41721N|ensembl:ENSG00000136848(gene)|ensembl:ENST00000408936(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005123"(death receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007049"(cell cycle)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010633"(negative regulation of epithelial cell migration)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021814"(cell motility involved in cerebral cortex radial glia guided migration)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021887|interpro:IPR023152|interpro:IPR030403|interpro:IPR035892|interpro:IPR039360|reactome:R-HSA-5658442|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0032809"(neuronal cell body membrane)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0035148"(tube formation)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0036324"(vascular endothelial growth factor receptor-2 signaling pathway)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0040008"(regulation of growth)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043184"(vascular endothelial growth factor receptor 2 binding)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043553"(negative regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044301"(climbing fiber)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045296"(cadherin binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090129"(positive regulation of synapse maturation)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900744"(regulation of p38MAPK cascade)|go:"GO:1900747"(negative regulation of vascular endothelial growth factor signaling pathway)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1903363"(negative regulation of cellular protein catabolic process)|go:"GO:1903896"(positive regulation of IRE1-mediated unfolded protein response)|go:"GO:1990032"(parallel fiber)|go:"GO:1990597"(AIP1-IRE1 complex)|go:"GO:2001224"(positive regulation of neuron migration)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|go:"GO:0070317"(negative regulation of G0 to G1 transition)	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:DmQot4h4SmtqmUGBgF5ictTah289606	rogid:JbFRnZ1gUoRogZz+WvJYHA57Ius9606	rigid:bEDLUh5HvEDhCmNi/HDZ6A3Wyuw	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51531	uniprotkb:Q9P0U4	intact:EBI-679562|uniprotkb:B1ALG3|uniprotkb:B1ALG4|uniprotkb:D3DRH4|uniprotkb:D3DRH5|ensembl:ENSP00000265773|ensembl:ENSP00000371638	intact:EBI-949911|ensembl:ENSP00000285106|uniprotkb:Q8N2W4|uniprotkb:Q96BC8|uniprotkb:Q9P2V7|uniprotkb:B2RC03	psi-mi:smca2_human(display_long)|uniprotkb:ATP-dependent helicase SMARCA2(gene name synonym)|uniprotkb:SNF2-alpha(gene name synonym)|uniprotkb:SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2(gene name synonym)|uniprotkb:SMARCA2(gene name)|psi-mi:SMARCA2(display_short)|uniprotkb:BRM(gene name synonym)|uniprotkb:SNF2A(gene name synonym)|uniprotkb:SNF2L2(gene name synonym)|uniprotkb:BAF190B(gene name synonym)|uniprotkb:Protein brahma homolog(gene name synonym)|uniprotkb:BRG1-associated factor 190B(gene name synonym)	psi-mi:cxxc1_human(display_long)|uniprotkb:CFP1(gene name synonym)|uniprotkb:PHD finger and CXXC domain-containing protein 1(gene name synonym)|uniprotkb:CXXC1(gene name)|psi-mi:CXXC1(display_short)|uniprotkb:CGBP(gene name synonym)|uniprotkb:PCCX1(gene name synonym)|uniprotkb:PHF18(gene name synonym)|uniprotkb:CpG-binding protein(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515232|imex:IM-28561-479	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003061.3|refseq:NP_620614.2|refseq:NP_001276325.1|refseq:NP_001276326.1|dip:DIP-29005N|ensembl:ENSG00000080503(gene)|ensembl:ENST00000349721(transcript)|ensembl:ENST00000382203(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007286"(spermatid development)|go:"GO:0007399"(nervous system development)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0042393"(histone binding)|go:"GO:0043044"|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070615"|go:"GO:0071564"(npBAF complex)|go:"GO:0071565"(nBAF complex)|interpro:IPR000330(SNF2-related)|interpro:IPR001487(Bromodomain)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006576(BRK)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014012(Helicase/SANT-associated, DNA binding)|interpro:IPR014978(QLQ)|interpro:IPR018359|interpro:IPR027417|interpro:IPR029295|interpro:IPR030088|interpro:IPR036427|interpro:IPR037259|interpro:IPR038718|mint:P51531|rcsb pdb:2DAT|rcsb pdb:4QY4|rcsb pdb:5DKC|rcsb pdb:5DKH|rcsb pdb:6EG2|rcsb pdb:6EG3|rcsb pdb:6HAX|rcsb pdb:6HAY|rcsb pdb:6HAZ|reactome:R-HSA-3214858|reactome:R-HSA-8939243	ensembl:ENSG00000154832(gene)|ensembl:ENST00000285106(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048188"(Set1C/COMPASS complex)|go:"GO:0051568"(histone H3-K4 methylation)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|reactome:R-HSA-381038|interpro:IPR022056|interpro:IPR037869|mint:Q9P0U4|rcsb pdb:3QMB|rcsb pdb:3QMC|rcsb pdb:3QMD|rcsb pdb:3QMG|rcsb pdb:3QMH|rcsb pdb:3QMI|refseq:NP_001095124.1|refseq:NP_055408.2|refseq:XP_011524242.1|refseq:XP_016881207.1|dip:DIP-50001N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:DmQot4h4SmtqmUGBgF5ictTah289606	rogid:nWwPX7OlafdCMD8Qg+hETjNkKgY9606	rigid:7nADivTGt0NXwXFaIgsOoPVdgCs	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51531	uniprotkb:Q8N137	intact:EBI-679562|uniprotkb:B1ALG3|uniprotkb:B1ALG4|uniprotkb:D3DRH4|uniprotkb:D3DRH5|ensembl:ENSP00000265773|ensembl:ENSP00000371638	intact:EBI-947360|uniprotkb:Q331K3|uniprotkb:Q69YV7|uniprotkb:Q8NCB8|uniprotkb:Q8WXV3|uniprotkb:Q96CQ7|uniprotkb:Q9C060|uniprotkb:A6NHQ1|intact:EBI-28975246|ensembl:ENSP00000456335	psi-mi:smca2_human(display_long)|uniprotkb:ATP-dependent helicase SMARCA2(gene name synonym)|uniprotkb:SNF2-alpha(gene name synonym)|uniprotkb:SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2(gene name synonym)|uniprotkb:SMARCA2(gene name)|psi-mi:SMARCA2(display_short)|uniprotkb:BRM(gene name synonym)|uniprotkb:SNF2A(gene name synonym)|uniprotkb:SNF2L2(gene name synonym)|uniprotkb:BAF190B(gene name synonym)|uniprotkb:Protein brahma homolog(gene name synonym)|uniprotkb:BRG1-associated factor 190B(gene name synonym)	psi-mi:cntrb_human(display_long)|uniprotkb:CNTROB(gene name)|psi-mi:CNTROB(display_short)|uniprotkb:LIP8(gene name synonym)|uniprotkb:PP1221(orf name)|uniprotkb:Centrosomal BRCA2-interacting protein(gene name synonym)|uniprotkb:LYST-interacting protein 8(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515225|imex:IM-28561-67	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003061.3|refseq:NP_620614.2|refseq:NP_001276325.1|refseq:NP_001276326.1|dip:DIP-29005N|ensembl:ENSG00000080503(gene)|ensembl:ENST00000349721(transcript)|ensembl:ENST00000382203(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007286"(spermatid development)|go:"GO:0007399"(nervous system development)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0042393"(histone binding)|go:"GO:0043044"|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070615"|go:"GO:0071564"(npBAF complex)|go:"GO:0071565"(nBAF complex)|interpro:IPR000330(SNF2-related)|interpro:IPR001487(Bromodomain)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006576(BRK)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014012(Helicase/SANT-associated, DNA binding)|interpro:IPR014978(QLQ)|interpro:IPR018359|interpro:IPR027417|interpro:IPR029295|interpro:IPR030088|interpro:IPR036427|interpro:IPR037259|interpro:IPR038718|mint:P51531|rcsb pdb:2DAT|rcsb pdb:4QY4|rcsb pdb:5DKC|rcsb pdb:5DKH|rcsb pdb:6EG2|rcsb pdb:6EG3|rcsb pdb:6HAX|rcsb pdb:6HAY|rcsb pdb:6HAZ|reactome:R-HSA-3214858|reactome:R-HSA-8939243	ensembl:ENST00000380262|ensembl:ENSP00000369614|ensembl:ENSP00000456335|ensembl:ENST00000565740|ensembl:ENSP00000454840|refseq:NP_001032221.1|refseq:NP_444279.2|refseq:NP_001317053.1|refseq:XP_016879617.1|refseq:XP_016879618.1|refseq:XP_016879619.1|refseq:XP_016879620.1|refseq:XP_016879621.1|refseq:XP_016879622.1|ensembl:ENSG00000170037(gene)|ensembl:ENST00000563694(transcript)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0007099"(centriole replication)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0051299"(centrosome separation)|go:"GO:1902017"(regulation of cilium assembly)|go:"GO:1902410"(mitotic cytokinetic process)|interpro:IPR038923|mint:Q8N137	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:DmQot4h4SmtqmUGBgF5ictTah289606	rogid:XL2jSsMcpCyE3Barag5kMiziCtU9606	rigid:x59yKwjar1F93/noXjRpa3Lw4XY	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51531	uniprotkb:Q9P209	intact:EBI-679562|uniprotkb:B1ALG3|uniprotkb:B1ALG4|uniprotkb:D3DRH4|uniprotkb:D3DRH5|ensembl:ENSP00000265773|ensembl:ENSP00000371638	intact:EBI-739498|uniprotkb:Q9BV03|uniprotkb:Q9BWM3|uniprotkb:Q9NVR4|uniprotkb:B4DR26|ensembl:ENSP00000264935	psi-mi:smca2_human(display_long)|uniprotkb:ATP-dependent helicase SMARCA2(gene name synonym)|uniprotkb:SNF2-alpha(gene name synonym)|uniprotkb:SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2(gene name synonym)|uniprotkb:SMARCA2(gene name)|psi-mi:SMARCA2(display_short)|uniprotkb:BRM(gene name synonym)|uniprotkb:SNF2A(gene name synonym)|uniprotkb:SNF2L2(gene name synonym)|uniprotkb:BAF190B(gene name synonym)|uniprotkb:Protein brahma homolog(gene name synonym)|uniprotkb:BRG1-associated factor 190B(gene name synonym)	psi-mi:cep72_human(display_long)|uniprotkb:CEP72(gene name)|psi-mi:CEP72(display_short)|uniprotkb:KIAA1519(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515218|imex:IM-28561-1139	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003061.3|refseq:NP_620614.2|refseq:NP_001276325.1|refseq:NP_001276326.1|dip:DIP-29005N|ensembl:ENSG00000080503(gene)|ensembl:ENST00000349721(transcript)|ensembl:ENST00000382203(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007286"(spermatid development)|go:"GO:0007399"(nervous system development)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0042393"(histone binding)|go:"GO:0043044"|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070615"|go:"GO:0071564"(npBAF complex)|go:"GO:0071565"(nBAF complex)|interpro:IPR000330(SNF2-related)|interpro:IPR001487(Bromodomain)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006576(BRK)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014012(Helicase/SANT-associated, DNA binding)|interpro:IPR014978(QLQ)|interpro:IPR018359|interpro:IPR027417|interpro:IPR029295|interpro:IPR030088|interpro:IPR036427|interpro:IPR037259|interpro:IPR038718|mint:P51531|rcsb pdb:2DAT|rcsb pdb:4QY4|rcsb pdb:5DKC|rcsb pdb:5DKH|rcsb pdb:6EG2|rcsb pdb:6EG3|rcsb pdb:6HAX|rcsb pdb:6HAY|rcsb pdb:6HAZ|reactome:R-HSA-3214858|reactome:R-HSA-8939243	refseq:NP_060610.2|ensembl:ENSG00000112877(gene)|ensembl:ENST00000264935(transcript)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007051"(spindle organization)|go:"GO:0007099"(centriole replication)|go:"GO:0033566"(gamma-tubulin complex localization)|go:"GO:0034451"(centriolar satellite)|go:"GO:1904779"(regulation of protein localization to centrosome)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR003603(U2A'/phosphoprotein 32 family A, C-terminal)|interpro:IPR032675|interpro:IPR040146|mint:Q9P209|reactome:R-HSA-2565942|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-8854518|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|refseq:XP_011512365.1|dip:DIP-54272N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:DmQot4h4SmtqmUGBgF5ictTah289606	rogid:c00WdgE2iudiQUz3kXNZL5d0nuQ9606	rigid:DOIpLGo9rChFB5LZb0hTU/KArPE	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51531	uniprotkb:Q96JN2	intact:EBI-679562|uniprotkb:B1ALG3|uniprotkb:B1ALG4|uniprotkb:D3DRH4|uniprotkb:D3DRH5|ensembl:ENSP00000265773|ensembl:ENSP00000371638	intact:EBI-947045|uniprotkb:A4D1K1|uniprotkb:Q6ZVK7|uniprotkb:Q9H8M3|uniprotkb:Q9UFE1|uniprotkb:A7MCY7|uniprotkb:A8MYA7|ensembl:ENSP00000297788	psi-mi:smca2_human(display_long)|uniprotkb:ATP-dependent helicase SMARCA2(gene name synonym)|uniprotkb:SNF2-alpha(gene name synonym)|uniprotkb:SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2(gene name synonym)|uniprotkb:SMARCA2(gene name)|psi-mi:SMARCA2(display_short)|uniprotkb:BRM(gene name synonym)|uniprotkb:SNF2A(gene name synonym)|uniprotkb:SNF2L2(gene name synonym)|uniprotkb:BAF190B(gene name synonym)|uniprotkb:Protein brahma homolog(gene name synonym)|uniprotkb:BRG1-associated factor 190B(gene name synonym)	psi-mi:cc136_human(display_long)|uniprotkb:NAG6(orf name)|uniprotkb:CCDC136(gene name)|psi-mi:CCDC136(display_short)|uniprotkb:KIAA1793(gene name synonym)|uniprotkb:Nasopharyngeal carcinoma-associated gene 6 protein(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515211|imex:IM-28561-1401	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003061.3|refseq:NP_620614.2|refseq:NP_001276325.1|refseq:NP_001276326.1|dip:DIP-29005N|ensembl:ENSG00000080503(gene)|ensembl:ENST00000349721(transcript)|ensembl:ENST00000382203(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007286"(spermatid development)|go:"GO:0007399"(nervous system development)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0042393"(histone binding)|go:"GO:0043044"|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070615"|go:"GO:0071564"(npBAF complex)|go:"GO:0071565"(nBAF complex)|interpro:IPR000330(SNF2-related)|interpro:IPR001487(Bromodomain)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006576(BRK)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014012(Helicase/SANT-associated, DNA binding)|interpro:IPR014978(QLQ)|interpro:IPR018359|interpro:IPR027417|interpro:IPR029295|interpro:IPR030088|interpro:IPR036427|interpro:IPR037259|interpro:IPR038718|mint:P51531|rcsb pdb:2DAT|rcsb pdb:4QY4|rcsb pdb:5DKC|rcsb pdb:5DKH|rcsb pdb:6EG2|rcsb pdb:6EG3|rcsb pdb:6HAX|rcsb pdb:6HAY|rcsb pdb:6HAZ|reactome:R-HSA-3214858|reactome:R-HSA-8939243	refseq:NP_001188301.1|refseq:NP_073579.4|refseq:XP_016868022.1|ensembl:ENSG00000128596(gene)|ensembl:ENST00000297788(transcript)|go:"GO:0001675"(acrosome assembly)|go:"GO:0002080"(acrosomal membrane)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0016021"(integral component of membrane)|mint:Q96JN2	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:DmQot4h4SmtqmUGBgF5ictTah289606	rogid:TEC/bwvyX2dh9hhk8JmyVUWhSKo9606	rigid:/lUSzBf2zt4XDnGUj07eq2bTdVQ	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51531	uniprotkb:O95996	intact:EBI-679562|uniprotkb:B1ALG3|uniprotkb:B1ALG4|uniprotkb:D3DRH4|uniprotkb:D3DRH5|ensembl:ENSP00000265773|ensembl:ENSP00000371638	intact:EBI-1053045|uniprotkb:Q05BW4|uniprotkb:Q9UBZ1|uniprotkb:Q9UEM8|uniprotkb:Q9UQJ8|uniprotkb:Q9UQJ9|uniprotkb:Q9Y632|ensembl:ENSP00000233607|ensembl:ENSP00000442954|ensembl:ENSP00000467073	psi-mi:smca2_human(display_long)|uniprotkb:ATP-dependent helicase SMARCA2(gene name synonym)|uniprotkb:SNF2-alpha(gene name synonym)|uniprotkb:SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2(gene name synonym)|uniprotkb:SMARCA2(gene name)|psi-mi:SMARCA2(display_short)|uniprotkb:BRM(gene name synonym)|uniprotkb:SNF2A(gene name synonym)|uniprotkb:SNF2L2(gene name synonym)|uniprotkb:BAF190B(gene name synonym)|uniprotkb:Protein brahma homolog(gene name synonym)|uniprotkb:BRG1-associated factor 190B(gene name synonym)	psi-mi:apcl_human(display_long)|uniprotkb:Adenomatous polyposis coli protein-like(gene name synonym)|uniprotkb:APC2(gene name)|psi-mi:APC2(display_short)|uniprotkb:APCL(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515204|imex:IM-28561-265	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003061.3|refseq:NP_620614.2|refseq:NP_001276325.1|refseq:NP_001276326.1|dip:DIP-29005N|ensembl:ENSG00000080503(gene)|ensembl:ENST00000349721(transcript)|ensembl:ENST00000382203(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007286"(spermatid development)|go:"GO:0007399"(nervous system development)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0042393"(histone binding)|go:"GO:0043044"|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070615"|go:"GO:0071564"(npBAF complex)|go:"GO:0071565"(nBAF complex)|interpro:IPR000330(SNF2-related)|interpro:IPR001487(Bromodomain)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006576(BRK)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014012(Helicase/SANT-associated, DNA binding)|interpro:IPR014978(QLQ)|interpro:IPR018359|interpro:IPR027417|interpro:IPR029295|interpro:IPR030088|interpro:IPR036427|interpro:IPR037259|interpro:IPR038718|mint:P51531|rcsb pdb:2DAT|rcsb pdb:4QY4|rcsb pdb:5DKC|rcsb pdb:5DKH|rcsb pdb:6EG2|rcsb pdb:6EG3|rcsb pdb:6HAX|rcsb pdb:6HAY|rcsb pdb:6HAZ|reactome:R-HSA-3214858|reactome:R-HSA-8939243	refseq:NP_005874.1|ensembl:ENSP00000233607|ensembl:ENSP00000442954|ensembl:ENSP00000467073|ensembl:ENSG00000115266(gene)|ensembl:ENST00000233607(transcript)|ensembl:ENST00000535453(transcript)|ensembl:ENST00000590469(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001708"(cell fate specification)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005884"(actin filament)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007389"(pattern specification process)|go:"GO:0007399"(nervous system development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0030496"(midbody)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR000225(Armadillo)|interpro:IPR009223(APC cysteine-rich)|interpro:IPR009224(SAMP)|interpro:IPR009234(APC basic)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026818|interpro:IPR026831|interpro:IPR026837|interpro:IPR032038|interpro:IPR036149|interpro:IPR041257|mint:O95996|refseq:XP_006722672.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:DmQot4h4SmtqmUGBgF5ictTah289606	rogid:v1BSNAoDD3R0+lrhI5zsOZvxFjQ9606	rigid:OnrvMsmMoCxoUP0JUCwVWuzYx34	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51531	uniprotkb:Q9NW15	intact:EBI-679562|uniprotkb:B1ALG3|uniprotkb:B1ALG4|uniprotkb:D3DRH4|uniprotkb:D3DRH5|ensembl:ENSP00000265773|ensembl:ENSP00000371638	intact:EBI-11349452|uniprotkb:B7WP12|uniprotkb:A8K8K3|uniprotkb:Q8IXX9|uniprotkb:C9JHS1|uniprotkb:B4DNK2|uniprotkb:B3KY93|uniprotkb:B4DJ83|uniprotkb:B3KTZ1|uniprotkb:A8MV74|ensembl:ENSP00000292246	psi-mi:smca2_human(display_long)|uniprotkb:ATP-dependent helicase SMARCA2(gene name synonym)|uniprotkb:SNF2-alpha(gene name synonym)|uniprotkb:SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2(gene name synonym)|uniprotkb:SMARCA2(gene name)|psi-mi:SMARCA2(display_short)|uniprotkb:BRM(gene name synonym)|uniprotkb:SNF2A(gene name synonym)|uniprotkb:SNF2L2(gene name synonym)|uniprotkb:BAF190B(gene name synonym)|uniprotkb:Protein brahma homolog(gene name synonym)|uniprotkb:BRG1-associated factor 190B(gene name synonym)	psi-mi:ano10_human(display_long)|uniprotkb:ANO10(gene name)|psi-mi:ANO10(display_short)|uniprotkb:TMEM16K(gene name synonym)|uniprotkb:Transmembrane protein 16K(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515197|imex:IM-28561-1399	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003061.3|refseq:NP_620614.2|refseq:NP_001276325.1|refseq:NP_001276326.1|dip:DIP-29005N|ensembl:ENSG00000080503(gene)|ensembl:ENST00000349721(transcript)|ensembl:ENST00000382203(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007286"(spermatid development)|go:"GO:0007399"(nervous system development)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0042393"(histone binding)|go:"GO:0043044"|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070615"|go:"GO:0071564"(npBAF complex)|go:"GO:0071565"(nBAF complex)|interpro:IPR000330(SNF2-related)|interpro:IPR001487(Bromodomain)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006576(BRK)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014012(Helicase/SANT-associated, DNA binding)|interpro:IPR014978(QLQ)|interpro:IPR018359|interpro:IPR027417|interpro:IPR029295|interpro:IPR030088|interpro:IPR036427|interpro:IPR037259|interpro:IPR038718|mint:P51531|rcsb pdb:2DAT|rcsb pdb:4QY4|rcsb pdb:5DKC|rcsb pdb:5DKH|rcsb pdb:6EG2|rcsb pdb:6EG3|rcsb pdb:6HAX|rcsb pdb:6HAY|rcsb pdb:6HAZ|reactome:R-HSA-3214858|reactome:R-HSA-8939243	refseq:NP_001191760.1|refseq:NP_001191761.1|refseq:NP_001191762.1|refseq:NP_001191763.1|refseq:NP_060545.3|refseq:NP_001333392.1|refseq:NP_001333393.1|refseq:NP_001333394.1|refseq:NP_001333395.1|refseq:NP_001333396.1|refseq:NP_001333397.1|refseq:NP_001333398.1|refseq:XP_016862211.1|ensembl:ENSG00000160746(gene)|ensembl:ENST00000292246(transcript)|go:"GO:0005227"(calcium activated cation channel activity)|go:"GO:0005229"(intracellular calcium activated chloride channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006821"(chloride transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0055085"(transmembrane transport)|interpro:IPR007632(Protein of unknown function DUF590)|interpro:IPR031291|rcsb pdb:5OC9|rcsb pdb:6R65|rcsb pdb:6R7X|rcsb pdb:6R7Y|rcsb pdb:6R7Z|reactome:R-HSA-2672351	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:DmQot4h4SmtqmUGBgF5ictTah289606	rogid:XRfkrBqltkpquCUp5CyaWn7pKJo9606	rigid:UQtGDpUmC8J6hThzhlPNqhinHoY	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51531	uniprotkb:P35609	intact:EBI-679562|uniprotkb:B1ALG3|uniprotkb:B1ALG4|uniprotkb:D3DRH4|uniprotkb:D3DRH5|ensembl:ENSP00000265773|ensembl:ENSP00000371638	intact:EBI-77797|uniprotkb:Q86TF4|ensembl:ENSP00000355537|uniprotkb:Q86TI8|uniprotkb:B1ANE4|intact:EBI-928705|uniprotkb:B2RCS5	psi-mi:smca2_human(display_long)|uniprotkb:ATP-dependent helicase SMARCA2(gene name synonym)|uniprotkb:SNF2-alpha(gene name synonym)|uniprotkb:SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2(gene name synonym)|uniprotkb:SMARCA2(gene name)|psi-mi:SMARCA2(display_short)|uniprotkb:BRM(gene name synonym)|uniprotkb:SNF2A(gene name synonym)|uniprotkb:SNF2L2(gene name synonym)|uniprotkb:BAF190B(gene name synonym)|uniprotkb:Protein brahma homolog(gene name synonym)|uniprotkb:BRG1-associated factor 190B(gene name synonym)	psi-mi:actn2_human(display_long)|uniprotkb:ACTN2(gene name)|psi-mi:ACTN2(display_short)|uniprotkb:Alpha-actinin skeletal muscle isoform 2(gene name synonym)|uniprotkb:F-actin cross-linking protein(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515190|imex:IM-28561-1397	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003061.3|refseq:NP_620614.2|refseq:NP_001276325.1|refseq:NP_001276326.1|dip:DIP-29005N|ensembl:ENSG00000080503(gene)|ensembl:ENST00000349721(transcript)|ensembl:ENST00000382203(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007286"(spermatid development)|go:"GO:0007399"(nervous system development)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0042393"(histone binding)|go:"GO:0043044"|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070615"|go:"GO:0071564"(npBAF complex)|go:"GO:0071565"(nBAF complex)|interpro:IPR000330(SNF2-related)|interpro:IPR001487(Bromodomain)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006576(BRK)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014012(Helicase/SANT-associated, DNA binding)|interpro:IPR014978(QLQ)|interpro:IPR018359|interpro:IPR027417|interpro:IPR029295|interpro:IPR030088|interpro:IPR036427|interpro:IPR037259|interpro:IPR038718|mint:P51531|rcsb pdb:2DAT|rcsb pdb:4QY4|rcsb pdb:5DKC|rcsb pdb:5DKH|rcsb pdb:6EG2|rcsb pdb:6EG3|rcsb pdb:6HAX|rcsb pdb:6HAY|rcsb pdb:6HAZ|reactome:R-HSA-3214858|reactome:R-HSA-8939243	refseq:NP_001094.1|ensembl:ENSG00000077522(gene)|ensembl:ENST00000366578(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005925"(focal adhesion)|go:"GO:0006936"(muscle contraction)|go:"GO:0007155"(cell adhesion)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030018"(Z disc)|go:"GO:0030035"(microspike assembly)|go:"GO:0030175"(filopodium)|go:"GO:0030274"(LIM domain binding)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031143"(pseudopodium)|go:"GO:0031432"(titin binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043267"(negative regulation of potassium ion transport)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045214"(sarcomere organization)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051015"(actin filament binding)|go:"GO:0051373"(FATZ binding)|go:"GO:0051695"(actin filament uncapping)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070080"(titin Z domain binding)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086097"(phospholipase C-activating angiotensin-activated signaling pathway)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|go:"GO:2001137"(positive regulation of endocytic recycling)|go:"GO:0030374"(nuclear receptor coactivator activity)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR036872|mint:P35609|rcsb pdb:1H8B|rcsb pdb:1HCI|rcsb pdb:1QUU|rcsb pdb:4D1E|rcsb pdb:5A36|rcsb pdb:5A37|rcsb pdb:5A38|rcsb pdb:5A4B|rcsb pdb:6SWT|rcsb pdb:6TS3|rcsb pdb:7A8T|rcsb pdb:7A8U|reactome:R-HSA-114608|go:"GO:2001259"(positive regulation of cation channel activity)|reactome:R-HSA-373753|reactome:R-HSA-390522|reactome:R-HSA-442982|reactome:R-HSA-5673001|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-9620244|reactome:R-HSA-438066|refseq:NP_001265272.1|refseq:NP_001265273.1|dip:DIP-383N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:DmQot4h4SmtqmUGBgF5ictTah289606	rogid:9jws8DZxpttkzqPfDxEzORNnwcE9606	rigid:kRbwLvVuKxrKkyxSrE+qjYu5kpo	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q96ST3	uniprotkb:Q15631	intact:EBI-347218|uniprotkb:Q8N8N4|uniprotkb:Q8NC83|uniprotkb:Q8WV18|uniprotkb:Q96L98|uniprotkb:Q9UFQ1|intact:EBI-28985143|ensembl:ENSP00000353622|ensembl:ENSP00000378402|ensembl:ENSP00000378403|uniprotkb:B2RNS5	intact:EBI-1044160|uniprotkb:Q5U0K7|ensembl:ENSP00000374332|uniprotkb:B7Z3X8	psi-mi:sin3a_human(display_long)|uniprotkb:SIN3A(gene name)|psi-mi:SIN3A(display_short)|uniprotkb:Transcriptional corepressor Sin3a(gene name synonym)|uniprotkb:Histone deacetylase complex subunit Sin3a(gene name synonym)	psi-mi:tsn_human(display_long)|uniprotkb:TSN(gene name)|psi-mi:TSN(display_short)|uniprotkb:Component 3 of promoter of RISC(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515183|imex:IM-28561-263	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006720528.1|ensembl:ENSG00000169375(gene)|ensembl:ENST00000360439(transcript)|ensembl:ENST00000394947(transcript)|ensembl:ENST00000394949(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000776"(kinetochore)|go:"GO:0000785"(chromatin)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006260"(DNA replication)|go:"GO:0006476"(protein deacetylation)|go:"GO:0007568"(aging)|go:"GO:0010817"(regulation of hormone levels)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016580"(Sin3 complex)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0021895"(cerebral cortex neuron differentiation)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0031937"(obsolete positive regulation of chromatin silencing)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043619"(regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048511"(rhythmic process)|go:"GO:0051595"(response to methylglyoxal)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0140416"(transcription regulator inhibitor activity)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:1901675"(negative regulation of histone H3-K27 acetylation)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:2000678"(negative regulation of transcription regulatory region DNA binding)|interpro:IPR003822(Paired amphipathic helix)|interpro:IPR013194(Histone deacetylase interacting)|interpro:IPR031693|interpro:IPR036600|interpro:IPR037969|interpro:IPR039774|mint:Q96ST3|reactome:R-HSA-3899300|reactome:R-HSA-400206|reactome:R-HSA-427413|reactome:R-HSA-8936459|reactome:R-HSA-9022538|reactome:R-HSA-9022692|reactome:R-HSA-9022699|reactome:R-HSA-9022702|rcsb pdb:1PO4|reactome:R-HSA-9615017|reactome:R-HSA-9707564|reactome:R-HSA-983231|refseq:XP_006720529.1|refseq:XP_006720530.1|refseq:NP_001138829.1|refseq:NP_001138830.1|refseq:NP_056292.1|ensembl:ENSP00000353622|ensembl:ENSP00000378402|ensembl:ENSP00000378403|dip:DIP-31515N	go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006310"(DNA recombination)|go:"GO:0016070"(RNA metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR002848(Translin)|interpro:IPR033956|interpro:IPR036081|mint:Q15631|rcsb pdb:1J1J|rcsb pdb:3PJA|interpro:IPR016068(Translin, N-terminal)|rcsb pdb:3QB5|rcsb pdb:4WYV|reactome:R-HSA-426486|interpro:IPR016069(Translin, C-terminal)|ensembl:ENSG00000211460(gene)|ensembl:ENST00000389682(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|refseq:NP_004613.1|refseq:NP_001248330.1|dip:DIP-42216N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pO/FziDcMNQRfy6ePi6eNKELXVM9606	rogid:Gv/cF7n6u7XUAQMK/YVsJ0yG93I9606	rigid:KNeMLwwOSewdF9D1yHYKSBzpeW0	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q96ST3	uniprotkb:Q5HYR2	intact:EBI-347218|uniprotkb:Q8N8N4|uniprotkb:Q8NC83|uniprotkb:Q8WV18|uniprotkb:Q96L98|uniprotkb:Q9UFQ1|intact:EBI-28985143|ensembl:ENSP00000353622|ensembl:ENSP00000378402|ensembl:ENSP00000378403|uniprotkb:B2RNS5	intact:EBI-26515137|ensembl:ENSP00000334501|ensembl:ENSP00000362632|ensembl:ENSP00000471224|ensembl:ENSP00000484718|uniprotkb:Q5HYR0|uniprotkb:Q5U5K2|uniprotkb:Q8N6L3|uniprotkb:Q96SD3	psi-mi:sin3a_human(display_long)|uniprotkb:SIN3A(gene name)|psi-mi:SIN3A(display_short)|uniprotkb:Transcriptional corepressor Sin3a(gene name synonym)|uniprotkb:Histone deacetylase complex subunit Sin3a(gene name synonym)	psi-mi:dmrtc_human(display_long)|uniprotkb:DMRTC1(gene name)|psi-mi:DMRTC1(display_short)|uniprotkb:DMRTC1B(gene name)|psi-mi:DMRTC1B(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515176|imex:IM-28561-477	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006720528.1|ensembl:ENSG00000169375(gene)|ensembl:ENST00000360439(transcript)|ensembl:ENST00000394947(transcript)|ensembl:ENST00000394949(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000776"(kinetochore)|go:"GO:0000785"(chromatin)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006260"(DNA replication)|go:"GO:0006476"(protein deacetylation)|go:"GO:0007568"(aging)|go:"GO:0010817"(regulation of hormone levels)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016580"(Sin3 complex)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0021895"(cerebral cortex neuron differentiation)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0031937"(obsolete positive regulation of chromatin silencing)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043619"(regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048511"(rhythmic process)|go:"GO:0051595"(response to methylglyoxal)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0140416"(transcription regulator inhibitor activity)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:1901675"(negative regulation of histone H3-K27 acetylation)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:2000678"(negative regulation of transcription regulatory region DNA binding)|interpro:IPR003822(Paired amphipathic helix)|interpro:IPR013194(Histone deacetylase interacting)|interpro:IPR031693|interpro:IPR036600|interpro:IPR037969|interpro:IPR039774|mint:Q96ST3|reactome:R-HSA-3899300|reactome:R-HSA-400206|reactome:R-HSA-427413|reactome:R-HSA-8936459|reactome:R-HSA-9022538|reactome:R-HSA-9022692|reactome:R-HSA-9022699|reactome:R-HSA-9022702|rcsb pdb:1PO4|reactome:R-HSA-9615017|reactome:R-HSA-9707564|reactome:R-HSA-983231|refseq:XP_006720529.1|refseq:XP_006720530.1|refseq:NP_001138829.1|refseq:NP_001138830.1|refseq:NP_056292.1|ensembl:ENSP00000353622|ensembl:ENSP00000378402|ensembl:ENSP00000378403|dip:DIP-31515N	ensembl:ENSG00000184911(gene)|ensembl:ENSG00000269502(gene)|ensembl:ENST00000334036(transcript)|ensembl:ENST00000373532(transcript)|ensembl:ENST00000595412(transcript)|ensembl:ENST00000615063(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|interpro:IPR026607|interpro:IPR031577|refseq:NP_001074320.1|refseq:NP_149042.2|refseq:XP_005262344.1|refseq:XP_005262345.1|refseq:XP_006724747.1|refseq:XP_006724748.1|refseq:XP_016885214.1|refseq:XP_016885265.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:pO/FziDcMNQRfy6ePi6eNKELXVM9606	rogid:nKohh3E1ODBXBiJBHFdue9WPZIw9606	rigid:6xkEHSY2l7HhDuNRbYHX2QwfleI	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q9C0B9	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-21901857|uniprotkb:B2RPG6|uniprotkb:Q8N3S1|uniprotkb:Q9NXF6|ensembl:ENSP00000269499	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:zchc2_human(display_long)|uniprotkb:ZCCHC2(gene name)|psi-mi:ZCCHC2(display_short)|uniprotkb:C18orf49(gene name synonym)|uniprotkb:KIAA1744(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515128|imex:IM-28561-65	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_060212.4|ensembl:ENSG00000141664(gene)|ensembl:ENST00000269499(transcript)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0035091"(phosphatidylinositol binding)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR036871|interpro:IPR036875|interpro:IPR042793	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:yS2EMrC4ydWMzezdWkPb9t/yJg09606	rigid:kHgGWI5juHqnoNMm+9R0NBnO+ag	false	sufficient binding region:374-740	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q9H0M0	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-742157|uniprotkb:O00307|uniprotkb:Q96BP4|ensembl:ENSP00000265428|ensembl:ENSP00000427793|uniprotkb:Q5YLC1	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:wwp1_human(display_long)|uniprotkb:WWP1(gene name)|psi-mi:WWP1(display_short)|uniprotkb:WW domain-containing protein 1(gene name synonym)|uniprotkb:Atrophin-1-interacting protein 5(gene name synonym)|uniprotkb:TGIF-interacting ubiquitin ligase 1(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase WWP1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515119|imex:IM-28561-927	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_008944.1|interpro:IPR035892|go:"GO:0045732"(positive regulation of protein catabolic process)|interpro:IPR035983|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR036020|mint:Q9H0M0|rcsb pdb:1ND7|rcsb pdb:2OP7|rcsb pdb:5HPS|rcsb pdb:5HPT|go:"GO:0046718"(viral entry into host cell)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|rcsb pdb:6J1X|rcsb pdb:6J1Y|reactome:R-HSA-1253288|reactome:R-HSA-2672351|reactome:R-HSA-8939902|reactome:R-HSA-983168|interpro:IPR024928|ensembl:ENSG00000123124(gene)|ensembl:ENST00000265428(transcript)|ensembl:ENST00000517970(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|refseq:XP_005250817.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:a+aRHHhwu3pCkmlkDNqcN1PJ7LI9606	rigid:Zl7N5a8GsM9r6Cl7lcaOYDmeLlM	false	sufficient binding region:791-1222	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:Q9P253	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-1053363|uniprotkb:Q8TCG0|uniprotkb:Q96DI3|uniprotkb:Q9H268|ensembl:ENSP00000220509	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:vps18_human(display_long)|uniprotkb:VPS18(gene name)|psi-mi:VPS18(display_short)|uniprotkb:KIAA1475(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515110|imex:IM-28561-1559	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	ensembl:ENSG00000104142(gene)|ensembl:ENST00000220509(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|refseq:NP_065908.1|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005884"(actin filament)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007032"(endosome organization)|go:"GO:0007033"(vacuole organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030123"(AP-3 adaptor complex)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030897"(HOPS complex)|go:"GO:0031902"(late endosome membrane)|go:"GO:0033147"(negative regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0033263"(CORVET complex)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0048284"(organelle fusion)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000547(Clathrin, heavy chain/VPS, 7-fold repeat)|interpro:IPR007810(Pep3/Vps18/deep orange)	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:/MgSM2SvqrSP9a2BA5IFOvPrwHc9606	rigid:lk7RWObpRJtC+zI3bF7tr9I4srI	false	sufficient binding region:374-740	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BYB0	uniprotkb:P08670	intact:EBI-1752330|uniprotkb:D7UT47|uniprotkb:Q8TET3|intact:EBI-28969573	intact:EBI-353844|uniprotkb:Q15867|uniprotkb:Q15868|uniprotkb:Q15869|uniprotkb:Q548L2|uniprotkb:Q6LER9|uniprotkb:Q8N850|uniprotkb:Q96ML2|uniprotkb:Q9NTM3|uniprotkb:B0YJC2|intact:EBI-3442369|uniprotkb:D3DRU4|ensembl:ENSP00000224237|ensembl:ENSP00000446007	psi-mi:shan3_human(display_long)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PSAP2(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)	psi-mi:vime_human(display_long)|uniprotkb:VIM(gene name)|psi-mi:VIM(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515101|imex:IM-28561-859	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-52267N|refseq:NP_277052.1|mint:Q9BYB0|go:"GO:0000165"(MAPK cascade)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0021773"(striatal medium spiny neuron differentiation)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030534"(adult behavior)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042297"(vocal learning)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043621"(protein self-association)|go:"GO:0044309"(neuron spine)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|rcsb pdb:6CPK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-6794361|reactome:R-HSA-8853659|go:"GO:1900452"(regulation of long-term synaptic depression)	refseq:NP_003371.2|ensembl:ENSG00000026025(gene)|ensembl:ENST00000224237(transcript)|ensembl:ENST00000544301(transcript)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005212"(structural constituent of eye lens)|go:"GO:0005737"(cytoplasm)|go:"GO:0005777"(peroxisome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014002"(astrocyte development)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031252"(cell leading edge)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0070307"(lens fiber cell development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071225"(cellular response to muramyl dipeptide)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1990254"(keratin filament binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|interpro:IPR027699|interpro:IPR039008|mint:P08670|rcsb pdb:1GK4|rcsb pdb:1GK6|rcsb pdb:1GK7|rcsb pdb:3G1E|rcsb pdb:3KLT|rcsb pdb:3S4R|rcsb pdb:3SSU|rcsb pdb:3SWK|rcsb pdb:3TRT|rcsb pdb:3UF1|rcsb pdb:4MCY|rcsb pdb:4MCZ|rcsb pdb:4MD0|rcsb pdb:4MD5|rcsb pdb:4MDI|rcsb pdb:4MDJ|rcsb pdb:4YPC|rcsb pdb:4YV3|rcsb pdb:5WHF|rcsb pdb:6ATF|rcsb pdb:6ATI|rcsb pdb:6BIR|rcsb pdb:6YXK|reactome:R-HSA-264870|reactome:R-HSA-390522|reactome:R-HSA-6785807|reactome:R-HSA-9013422|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9646399|refseq:XP_006717563.1|dip:DIP-32507N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rogid:GhAhVuXMNxi6P5J0CfNi5l9bjRk9606	rigid:I79jJBhHCwqUEGtgQV941p3thkY	false	sufficient binding region:374-740	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q92574	uniprotkb:P54259	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	intact:EBI-945980|uniprotkb:Q99495|uniprotkb:Q99621|uniprotkb:Q9UEK7|ensembl:ENSP00000349076|ensembl:ENSP00000379915	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:atn1_human(display_long)|uniprotkb:ATN1(gene name)|psi-mi:ATN1(display_short)|uniprotkb:DRPLA(gene name synonym)|uniprotkb:Dentatorubral-pallidoluysian atrophy protein(gene name synonym)|uniprotkb:D12S755E(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515443|imex:IM-28561-935	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	refseq:NP_001007027.1|refseq:NP_001931.2|ensembl:ENSP00000349076|ensembl:ENSP00000379915|dip:DIP-29423N|ensembl:ENSG00000111676(gene)|ensembl:ENST00000356654(transcript)|ensembl:ENST00000396684(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0007417"(central nervous system development)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030054"(cell junction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|interpro:IPR002951(Atrophin)|interpro:IPR017993|mint:P54259|reactome:R-HSA-8943724	-	-	crc64:B47603486C672637	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	rogid:SX8MuZ4aW8/PJmQl4HqY+NOSxbI9606	rigid:kusmJNcNYEiaLYkGWjPlLwf7iI0	false	sufficient binding region:720-1000	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q92574	uniprotkb:Q8TF21	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	intact:EBI-711719|uniprotkb:O75268|uniprotkb:O95781|ensembl:ENSP00000321731|ensembl:ENSP00000471252	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:anr24_human(display_long)|uniprotkb:ANKRD24(gene name)|psi-mi:ANKRD24(display_short)|uniprotkb:KIAA1981(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515425|imex:IM-28561-1639	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	refseq:NP_597732.1|ensembl:ENSG00000089847(gene)|ensembl:ENST00000318934(transcript)|ensembl:ENST00000600132(transcript)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	rogid:lDNidwheVjtjM1YFu/QknFXPz709606	rigid:7lBVpY4rt+FlvkitQvr0bylsOA0	false	sufficient binding region:720-1000	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q92574	uniprotkb:Q8N283	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	intact:EBI-2813523|uniprotkb:B4DL62|uniprotkb:A6NEU0|uniprotkb:Q3MJ10|uniprotkb:Q96LS3|ensembl:ENSP00000347802	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:anr35_human(display_long)|uniprotkb:ANKRD35(gene name)|psi-mi:ANKRD35(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515434|imex:IM-28561-1641	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	ensembl:ENSG00000198483(gene)|ensembl:ENST00000355594(transcript)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|mint:Q8N283|refseq:NP_653299.4	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	rogid:gKpYjof24pm0XACs5Co0Kuu5gXc9606	rigid:UQ/GNMyv+hXjpf4johv2/H4XMPg	false	sufficient binding region:720-1000	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q92574	uniprotkb:Q9NWZ8	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	intact:EBI-2626001|uniprotkb:C4AMC4|uniprotkb:Q2LJ66|uniprotkb:Q6ZV27|ensembl:ENSP00000369895|ensembl:ENSP00000381398|ensembl:ENSP00000505279|ensembl:ENSP00000505429	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:gemi8_human(display_long)|uniprotkb:GEMIN8(gene name)|psi-mi:GEMIN8(display_short)|uniprotkb:FAM51A1(gene name synonym)|uniprotkb:Protein FAM51A1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515632|imex:IM-28561-87	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	refseq:NP_001035944.1|refseq:NP_001035945.1|refseq:NP_060326.1|refseq:XP_016885106.1|refseq:XP_016885107.1|ensembl:ENSG00000046647(gene)|ensembl:ENST00000380523(transcript)|ensembl:ENST00000398355(transcript)|ensembl:ENST00000477386(transcript)|ensembl:ENST00000680255(transcript)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0032797"(SMN complex)|go:"GO:0034719"(SMN-Sm protein complex)|go:"GO:0097504"(Gemini of coiled bodies)|interpro:IPR034754|mint:Q9NWZ8|rcsb pdb:7BBL|reactome:R-HSA-191859	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	rogid:Lvyive5mtL+89HujsYibFUTFP1k9606	rigid:83cGzpV1D5cgay8kMyOI2vs1pbQ	false	sufficient binding region:720-1000	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q92574	uniprotkb:P14136	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	intact:EBI-744302|uniprotkb:Q53H98|uniprotkb:Q5D055|uniprotkb:Q6ZQS3|uniprotkb:Q7Z5J6|uniprotkb:Q7Z5J7|uniprotkb:Q96KS4|uniprotkb:Q96P18|uniprotkb:Q9UFD0|uniprotkb:B2RD44|uniprotkb:D3DX59|intact:EBI-3909365|uniprotkb:E9PAX3|ensembl:ENSP00000466598|uniprotkb:A7REI1	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:gfap_human(display_long)|uniprotkb:GFAP(gene name)|psi-mi:GFAP(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515641|imex:IM-28561-733	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	refseq:NP_001124491.1|refseq:NP_001229305.1|refseq:NP_002046.1|ensembl:ENSG00000131095(gene)|ensembl:ENST00000588735(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0009611"(response to wounding)|go:"GO:0010467"(gene expression)|go:"GO:0010625"(positive regulation of Schwann cell proliferation)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014002"(astrocyte development)|go:"GO:0019900"(kinase binding)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031102"(neuron projection regeneration)|go:"GO:0042802"(identical protein binding)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0044297"(cell body)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0051580"(regulation of neurotransmitter uptake)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0070779"(D-aspartate import across plasma membrane)|go:"GO:0097450"(astrocyte end-foot)|go:"GO:0098574"(cytoplasmic side of lysosomal membrane)|go:"GO:1904714"(regulation of chaperone-mediated autophagy)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|interpro:IPR027701|interpro:IPR039008|mint:P14136|rcsb pdb:6A9P|reactome:R-HSA-1251985|reactome:R-HSA-9613829	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	rogid:Pz4JW0WjMjBYILTDSX9jUmMqWhg9606	rigid:BmmtO6pQHcj3TOdCIHg1uqr95yg	false	sufficient binding region:720-1000	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q92574	uniprotkb:P02794	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	intact:EBI-713259|uniprotkb:Q3KRA8|uniprotkb:Q3SWW1|ensembl:ENSP00000273550|ensembl:ENSP00000484477|uniprotkb:B3KNR5	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:frih_human(display_long)|uniprotkb:Cell proliferation-inducing gene 15 protein(gene name synonym)|uniprotkb:FTH1(gene name)|psi-mi:FTH1(display_short)|uniprotkb:FTH(gene name synonym)|uniprotkb:FTHL6(gene name synonym)|uniprotkb:PIG15(orf name)|uniprotkb:OK/SW-cl.84(orf name)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515614|imex:IM-28561-1421	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	refseq:NP_002023.2|ensembl:ENSG00000167996(gene)|ensembl:ENST00000273550(transcript)|ensembl:ENST00000620041(transcript)|go:"GO:0004322"(ferroxidase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006826"(iron ion transport)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0006880"(intracellular sequestering of iron ion)|go:"GO:0006955"(immune response)|go:"GO:0008043"(intracellular ferritin complex)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008199"(ferric iron binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0044754"(autolysosome)|mint:P02794|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:1FHA|rcsb pdb:2CEI|rcsb pdb:2CHI|rcsb pdb:2CIH|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR001519(Ferritin, N-terminal)|interpro:IPR008331(Ferritin and Dps)|interpro:IPR009040(Ferritin-like)|interpro:IPR009078(Ferritin/ribonucleotide reductase-like)|interpro:IPR012347(Ferritin-related)|interpro:IPR014034(Ferritin, conserved site)|rcsb pdb:2CLU|rcsb pdb:2CN6|rcsb pdb:2CN7|rcsb pdb:2FHA|rcsb pdb:2IU2|rcsb pdb:2Z6M|rcsb pdb:3AJO|rcsb pdb:3AJP|rcsb pdb:3AJQ|rcsb pdb:3ERZ|rcsb pdb:3ES3|rcsb pdb:4DYX|rcsb pdb:4DYY|rcsb pdb:4DYZ|rcsb pdb:4Y08|rcsb pdb:4YKH|rcsb pdb:4ZJK|rcsb pdb:5CMQ|rcsb pdb:5CMR|rcsb pdb:5GN8|rcsb pdb:5GOU|rcsb pdb:5JKK|rcsb pdb:5JKL|rcsb pdb:5JKM|rcsb pdb:5N26|rcsb pdb:5N27|rcsb pdb:5UP7|rcsb pdb:5UP8|rcsb pdb:5UP9|rcsb pdb:5VTD|rcsb pdb:5XB1|rcsb pdb:5YI5|rcsb pdb:5ZND|rcsb pdb:6B8F|rcsb pdb:6B8G|rcsb pdb:4DZ0|rcsb pdb:6FTV|rcsb pdb:6GSR|rcsb pdb:6H5I|rcsb pdb:6H6T|rcsb pdb:6H6U|rcsb pdb:6IPC|rcsb pdb:6IPO|rcsb pdb:6IPP|rcsb pdb:6IPQ|rcsb pdb:6J4A|rcsb pdb:6J7G|rcsb pdb:6JOB|rcsb pdb:6JPS|rcsb pdb:6KE2|rcsb pdb:6KE4|rcsb pdb:4OYN|rcsb pdb:6M52|rcsb pdb:6M54|rcsb pdb:6WYF|rcsb pdb:6WYG|rcsb pdb:6WYH|rcsb pdb:6Z6U|rcsb pdb:6Z9E|rcsb pdb:6Z9F|rcsb pdb:7A6A|rcsb pdb:7A6B|rcsb pdb:7CK8|rcsb pdb:7CK9|rcsb pdb:7JGK|rcsb pdb:7JGL|rcsb pdb:7JGM|rcsb pdb:7JGN|rcsb pdb:7JGO|rcsb pdb:7JGP|rcsb pdb:7JGQ|rcsb pdb:7K26|rcsb pdb:7K3V|rcsb pdb:7K3W|reactome:R-HSA-3000480|reactome:R-HSA-432722|reactome:R-HSA-6798695|reactome:R-HSA-917937|dip:DIP-38301N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	rogid:TchHgRpv+inA8BQ5i0OHaa267tQ9606	rigid:/dEAsMaVAr2dxEUpBCqqfyC2+XU	false	sufficient binding region:720-1000	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q92574	uniprotkb:Q8TES7	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	intact:EBI-2350063|uniprotkb:B5MEM5|uniprotkb:Q96IF6|uniprotkb:Q96MA8|uniprotkb:Q96JG4|ensembl:ENSP00000465132	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:fbf1_human(display_long)|uniprotkb:ALB(gene name synonym)|uniprotkb:Protein albatross(gene name synonym)|uniprotkb:FBF1(gene name)|psi-mi:FBF1(display_short)|uniprotkb:KIAA1863(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515605|imex:IM-28561-489	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	refseq:NP_001306122.1|ensembl:ENSG00000188878(gene)|ensembl:ENST00000586717(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0030054"(cell junction)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043297"(apical junction assembly)|go:"GO:0060271"(cilium assembly)|go:"GO:0090162"(establishment of epithelial cell polarity)|go:"GO:0097539"(ciliary transition fiber)|interpro:IPR033561|reactome:R-HSA-5620912	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	rogid:L3WrrMbCU9aCdYlXB4h9s/WVU2o9606	rigid:EK06S+ch+sNdqO2+YfwNXCjLyec	false	sufficient binding region:720-1000	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q92574	uniprotkb:Q14152	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	intact:EBI-366617|uniprotkb:O00653|uniprotkb:Q15778|uniprotkb:B1AMV5|intact:EBI-28978176|ensembl:ENSP00000358140|ensembl:ENSP00000438178|uniprotkb:B4DYS1|uniprotkb:F5H335	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:eif3a_human(display_long)|uniprotkb:EIF3A(gene name)|psi-mi:EIF3A(display_short)|uniprotkb:KIAA0139(gene name synonym)|uniprotkb:EIF3S10(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 10(gene name synonym)|uniprotkb:eIF-3-theta(gene name synonym)|uniprotkb:eIF3 p167(gene name synonym)|uniprotkb:eIF3 p180(gene name synonym)|uniprotkb:eIF3 p185(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515596|imex:IM-28561-1645	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	refseq:NP_003741.1|ensembl:ENSP00000358140|ensembl:ENSP00000438178|ensembl:ENSG00000107581(gene)|ensembl:ENST00000369144(transcript)|ensembl:ENST00000541549(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0002188"(translation reinitiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0005874"(microtubule)|go:"GO:0006413"(translational initiation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0043614"(multi-eIF complex)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071540"(eukaryotic translation initiation factor 3 complex, eIF3e)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0075522"(IRES-dependent viral translational initiation)|go:"GO:0075525"(viral translational termination-reinitiation)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR027512|mint:Q14152|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6YBT|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-31114N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	rogid:COyPBU7e0SUL3BiZY7NQuUkmxns9606	rigid:OXw+d5sjKIaOQfZCJcx77IjVPp4	false	sufficient binding region:720-1000	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q92574	uniprotkb:Q13561	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	intact:EBI-715074|uniprotkb:Q86YN2|uniprotkb:Q9BW17|uniprotkb:B2RBK5|ensembl:ENSP00000447824	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:dctn2_human(display_long)|uniprotkb:Dynactin complex 50 kDa subunit(gene name synonym)|uniprotkb:50 kDa dynein-associated polypeptide(gene name synonym)|uniprotkb:p50 dynamitin(gene name synonym)|uniprotkb:DCTN2(gene name)|psi-mi:DCTN2(display_short)|uniprotkb:DCTN50(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515587|imex:IM-28561-85	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	refseq:NP_006391.1|refseq:NP_001248341.1|refseq:NP_001248342.1|dip:DIP-37545N|reactome:R-HSA-2565942|reactome:R-HSA-3371497|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-6807878|reactome:R-HSA-6811436|reactome:R-HSA-8854518|ensembl:ENSG00000175203(gene)|ensembl:ENST00000548249(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005869"(dynactin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030286"(dynein complex)|go:"GO:0030426"(growth cone)|go:"GO:0030507"(spectrin binding)|go:"GO:0031982"(vesicle)|go:"GO:0032402"(melanosome transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071539"(protein localization to centrosome)|interpro:IPR028133|mint:Q13561|reactome:R-HSA-2132295	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	rogid:JrL5jUtArek+zqmCkPKomnjuSf09606	rigid:CqUAP0FTrHIkc7NT1kcVG63gSQ4	false	sufficient binding region:720-1000	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q92574	uniprotkb:Q96NX9	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	intact:EBI-20842710|ensembl:ENSP00000362217|uniprotkb:B1AJV3|uniprotkb:B4DQG3|uniprotkb:Q8NAY3|uniprotkb:Q8ND17|uniprotkb:Q96N55	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:dach2_human(display_long)|uniprotkb:DACH2(gene name)|psi-mi:DACH2(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515578|imex:IM-28561-83	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	ensembl:ENSG00000126733(gene)|ensembl:ENST00000373125(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046545"(development of primary female sexual characteristics)|interpro:IPR003380(Transforming protein Ski)|interpro:IPR009061(Putative DNA binding)|interpro:IPR037000|refseq:NP_001132986.1|refseq:NP_001132987.1|refseq:NP_444511.1|refseq:XP_016884745.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	rogid:hRuAzD+2XxsyYH75/g0IM8tOAWY9606	rigid:6ORh8NeJ4oTxOfOwC+puKNrWnMs	false	sufficient binding region:720-1000	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q92574	uniprotkb:P35222	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	intact:EBI-491549|uniprotkb:Q8NEW9|uniprotkb:Q8NI94|uniprotkb:Q9H391|ensembl:ENSP00000344456|ensembl:ENSP00000379486|ensembl:ENSP00000379488|ensembl:ENSP00000385604|ensembl:ENSP00000387455|ensembl:ENSP00000401599|ensembl:ENSP00000409302|ensembl:ENSP00000412219|ensembl:ENSP00000493533|ensembl:ENSP00000493610|ensembl:ENSP00000494053|ensembl:ENSP00000494411|ensembl:ENSP00000494677|ensembl:ENSP00000494845|ensembl:ENSP00000494914|ensembl:ENSP00000495076|ensembl:ENSP00000495244|ensembl:ENSP00000495360|ensembl:ENSP00000495450|ensembl:ENSP00000495719|ensembl:ENSP00000495992|ensembl:ENSP00000496021|ensembl:ENSP00000496180|ensembl:ENSP00000496385|uniprotkb:A8K1L7|intact:EBI-491563	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:ctnb1_human(display_long)|uniprotkb:Beta-catenin(gene name synonym)|uniprotkb:OK/SW-cl.35(orf name)|uniprotkb:PRO2286(orf name)|uniprotkb:CTNNB1(gene name)|psi-mi:CTNNB1(display_short)|uniprotkb:CTNNB(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515569|imex:IM-28561-1147	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	ensembl:ENSG00000168036(gene)|ensembl:ENST00000349496(transcript)|ensembl:ENST00000396183(transcript)|ensembl:ENST00000396185(transcript)|ensembl:ENST00000405570(transcript)|ensembl:ENST00000431914(transcript)|ensembl:ENST00000441708(transcript)|ensembl:ENST00000450969(transcript)|ensembl:ENST00000642248(transcript)|ensembl:ENST00000642315(transcript)|ensembl:ENST00000642426(transcript)|ensembl:ENST00000642992(transcript)|ensembl:ENST00000643031(transcript)|ensembl:ENST00000643297(transcript)|ensembl:ENST00000643541(transcript)|ensembl:ENST00000643977(transcript)|ensembl:ENST00000643992(transcript)|ensembl:ENST00000644867(transcript)|ensembl:ENST00000645210(transcript)|ensembl:ENST00000645320(transcript)|ensembl:ENST00000645982(transcript)|ensembl:ENST00000433400(transcript)|ensembl:ENST00000646369(transcript)|ensembl:ENST00000647390(transcript)|ensembl:ENST00000646725(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000578"(embryonic axis specification)|reactome:R-HSA-351906|reactome:R-HSA-3769402|reactome:R-HSA-3134973|reactome:R-HSA-381771|reactome:R-HSA-4086398|reactome:R-HSA-418990|reactome:R-HSA-4411364|reactome:R-HSA-4641262|reactome:R-HSA-5218920|reactome:R-HSA-525793|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5626467|reactome:R-HSA-8853884|reactome:R-HSA-8876493|reactome:R-HSA-8951430|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045976"(negative regulation of mitotic cell cycle, embryonic)|go:"GO:0046332"(SMAD binding)|go:"GO:0048145"(regulation of fibroblast proliferation)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0048538"(thymus development)|go:"GO:0048599"(oocyte development)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0045743"(positive regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0048715"(negative regulation of oligodendrocyte differentiation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010909"(positive regulation of heparan sulfate proteoglycan biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016600"(flotillin complex)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0022009"(central nervous system vasculogenesis)|go:"GO:0030018"(Z disc)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030539"(male genitalia development)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0030902"(hindbrain development)|go:"GO:0030997"(regulation of centriole-centriole cohesion)|go:"GO:0031016"(pancreas development)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032355"(response to estradiol)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034750"(Scrib-APC-beta-catenin complex)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035112"(genitalia morphogenesis)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035315"(hair cell differentiation)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0036023"(embryonic skeletal limb joint morphogenesis)|go:"GO:0036520"(astrocyte-dopaminergic neuron signaling)|go:"GO:0042129"(regulation of T cell proliferation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042493"|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044334"(canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition)|go:"GO:0044336"(canonical Wnt signaling pathway involved in negative regulation of apoptotic process)|go:"GO:0044338"(canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045453"(bone resorption)|go:"GO:0045603"(positive regulation of endothelial cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:0060479"(lung cell differentiation)|go:"GO:0060484"(lung-associated mesenchyme development)|go:"GO:0060492"(lung induction)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0060769"(positive regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0051145"(smooth muscle cell differentiation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051884"(regulation of timing of anagen)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060789"(hair follicle placode formation)|go:"GO:0060916"(mesenchymal cell proliferation involved in lung development)|go:"GO:0061047"(positive regulation of branching involved in lung morphogenesis)|go:"GO:0061154"(endothelial tube morphogenesis)|go:"GO:0061198"(fungiform papilla formation)|go:"GO:0061324"(canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation)|go:"GO:0061549"(sympathetic ganglion development)|go:"GO:0061550"(cranial ganglion development)|go:"GO:0060066"(oviduct development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070369"(beta-catenin-TCF7L2 complex)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070602"(regulation of centromeric sister chromatid cohesion)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0071944"(cell periphery)|go:"GO:0072033"(renal vesicle formation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060440"(trachea formation)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007398"(ectoderm development)|go:"GO:0007403"(glial cell fate determination)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0005916"(fascia adherens)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0072054"(renal outer medulla development)|go:"GO:0072079"(nephron tubule formation)|go:"GO:0072182"(regulation of nephron tubule epithelial cell differentiation)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097091"(synaptic vesicle clustering)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1904798"(positive regulation of core promoter binding)|go:"GO:1904888"(cranial skeletal system development)|go:"GO:1904948"(midbrain dopaminergic neuron differentiation)|go:"GO:1904954"(canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990403"(embryonic brain development)|go:"GO:1990791"(dorsal root ganglion development)|go:"GO:1990907"(beta-catenin-TCF complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000008"(regulation of protein localization to cell surface)|go:"GO:2000017"(positive regulation of determination of dorsal identity)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013284(Beta-catenin)|interpro:IPR016024(Armadillo-type fold)|mint:P35222|rcsb pdb:1G3J|rcsb pdb:1JDH|rcsb pdb:1JPW|rcsb pdb:1LUJ|rcsb pdb:1P22|rcsb pdb:1QZ7|rcsb pdb:1T08|rcsb pdb:1TH1|rcsb pdb:2G57|rcsb pdb:2GL7|rcsb pdb:2Z6H|rcsb pdb:3DIW|rcsb pdb:3FQN|rcsb pdb:3FQR|rcsb pdb:3SL9|rcsb pdb:3SLA|rcsb pdb:3TX7|rcsb pdb:4DJS|rcsb pdb:6M90|rcsb pdb:6M91|rcsb pdb:6M92|rcsb pdb:6M93|rcsb pdb:6M94|rcsb pdb:6O9B|rcsb pdb:6O9C|rcsb pdb:6WLX|rcsb pdb:6WNX|rcsb pdb:7AFW|go:"GO:0072053"(renal inner medulla development)|rcsb pdb:7AR4|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-201681|reactome:R-HSA-201722|go:"GO:0000791"(euchromatin)|go:"GO:0000922"(spindle pole)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001708"(cell fate specification)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0001764"(neuron migration)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001840"(neural plate development)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0003266"(regulation of secondary heart field cardioblast proliferation)|go:"GO:0003338"(metanephros morphogenesis)|go:"GO:0003340"(negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0000904"(cell morphogenesis involved in differentiation)|dip:DIP-122N|refseq:NP_001091679.1|refseq:NP_001091680.1|refseq:NP_001895.1|refseq:XP_005264943.1|refseq:XP_016861227.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	rogid:WLs7+T0WG4DiBStdS5+lR7i83dk9606	rigid:IXnng6+OIV7pX2V+2vakjmzSrFg	false	sufficient binding region:720-1000	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q92574	uniprotkb:Q9Y2V7	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	intact:EBI-3866319|uniprotkb:Q86V49|uniprotkb:Q5T0U1|uniprotkb:Q9ULT5|uniprotkb:Q6AI19|ensembl:ENSP00000397441	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:cog6_human(display_long)|uniprotkb:COG6(gene name)|psi-mi:COG6(display_short)|uniprotkb:KIAA1134(gene name synonym)|uniprotkb:Component of oligomeric Golgi complex 6(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515560|imex:IM-28561-1419	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	refseq:NP_001138551.1|refseq:NP_065802.1|dip:DIP-48931N|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0070085"(glycosylation)|interpro:IPR010490(Conserved oligomeric complex COG6)|reactome:R-HSA-6807878|reactome:R-HSA-6811438|reactome:R-HSA-6811440|ensembl:ENSG00000133103(gene)|ensembl:ENST00000455146(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0015031"(protein transport)|go:"GO:0017119"(Golgi transport complex)	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	rogid:1S6ym3UxcjqPpQ9WCWf3060I9jE9606	rigid:2bpdru4Wuc3KJSl3+SIW8PqErlc	false	sufficient binding region:720-1000	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q92574	uniprotkb:Q8N137	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	intact:EBI-947360|uniprotkb:Q331K3|uniprotkb:Q69YV7|uniprotkb:Q8NCB8|uniprotkb:Q8WXV3|uniprotkb:Q96CQ7|uniprotkb:Q9C060|uniprotkb:A6NHQ1|intact:EBI-28975246|ensembl:ENSP00000456335	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:cntrb_human(display_long)|uniprotkb:CNTROB(gene name)|psi-mi:CNTROB(display_short)|uniprotkb:LIP8(gene name synonym)|uniprotkb:PP1221(orf name)|uniprotkb:Centrosomal BRCA2-interacting protein(gene name synonym)|uniprotkb:LYST-interacting protein 8(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515551|imex:IM-28561-487	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	ensembl:ENST00000380262|ensembl:ENSP00000369614|ensembl:ENSP00000456335|ensembl:ENST00000565740|ensembl:ENSP00000454840|refseq:NP_001032221.1|refseq:NP_444279.2|refseq:NP_001317053.1|refseq:XP_016879617.1|refseq:XP_016879618.1|refseq:XP_016879619.1|refseq:XP_016879620.1|refseq:XP_016879621.1|refseq:XP_016879622.1|ensembl:ENSG00000170037(gene)|ensembl:ENST00000563694(transcript)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0007099"(centriole replication)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0051299"(centrosome separation)|go:"GO:1902017"(regulation of cilium assembly)|go:"GO:1902410"(mitotic cytokinetic process)|interpro:IPR038923|mint:Q8N137	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	rogid:XL2jSsMcpCyE3Barag5kMiziCtU9606	rigid:R0rR79N+0LGx4zjiz5NH06hhrjM	false	sufficient binding region:720-1000	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q92574	uniprotkb:O95406	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	intact:EBI-12172273|ensembl:ENSP00000216416|uniprotkb:Q3SYM7	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:cnih1_human(display_long)|uniprotkb:CNIH1(gene name)|psi-mi:CNIH1(display_short)|uniprotkb:CNIH(gene name synonym)|uniprotkb:CNIL(gene name synonym)|uniprotkb:Cornichon family AMPA receptor auxiliary protein 1(gene name synonym)|uniprotkb:Protein cornichon homolog(gene name synonym)|uniprotkb:T-cell growth-associated molecule 77(gene name synonym)|uniprotkb:UNQ155/PRO181(orf name)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515542|imex:IM-28561-937	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	ensembl:ENSG00000100528(gene)|ensembl:ENST00000216416(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|interpro:IPR003377(Cornichon)|interpro:IPR033466|reactome:R-HSA-204005|reactome:R-HSA-5694530|refseq:NP_005767.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	rogid:k3gM9v3zEsJ4DGRL7k87ZFhe0iA9606	rigid:1ddeMPNzZJgYq5RrB90/AmdH2DI	false	sufficient binding region:720-1000	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q92574	uniprotkb:Q7Z7A1	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	intact:EBI-2563266|uniprotkb:A2A2Y1|uniprotkb:B2RP67|uniprotkb:Q3MN79|uniprotkb:Q5FWF8|uniprotkb:Q5JVD0|uniprotkb:Q9Y489|uniprotkb:Q8TEP3|uniprotkb:Q6MZR3|uniprotkb:Q6PKC1|intact:EBI-2796138|ensembl:ENSP00000362962	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:cntrl_human(display_long)|uniprotkb:CEP1(gene name synonym)|uniprotkb:Centrosomal protein of 110 kDa(gene name synonym)|uniprotkb:Centrosomal protein 1(gene name synonym)|uniprotkb:CNTRL(gene name)|psi-mi:CNTRL(display_short)|uniprotkb:CEP110(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515533|imex:IM-28561-719	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	refseq:NP_008949.4|ensembl:ENSG00000119397(gene)|ensembl:ENST00000373855(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0003281"(ventricular septum development)|go:"GO:0005813"(centrosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0016020"(membrane)|go:"GO:0035904"(aorta development)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051301"(cell division)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0090543"(Flemming body)|go:"GO:0090619"(meiotic spindle pole)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0120103"(centriolar subdistal appendage)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR028640|interpro:IPR032675|mint:Q7Z7A1|reactome:R-HSA-1839117|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-5655302|reactome:R-HSA-8854518|refseq:XP_005251736.1|refseq:NP_001317691.1|dip:DIP-47280N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	rogid:wmPF3eCXN2WiNQIyd0CR3OGJROo9606	rigid:g2PbLqHKVZPyG9lMF9zPSMhhsgM	false	sufficient binding region:720-1000	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q92574	uniprotkb:Q01850	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	intact:EBI-1181367|uniprotkb:Q13977|uniprotkb:A8K8A8|ensembl:ENSP00000268383	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:cdr2_human(display_long)|uniprotkb:Paraneoplastic cerebellar degeneration-associated antigen(gene name synonym)|uniprotkb:Major Yo paraneoplastic antigen(gene name synonym)|uniprotkb:CDR2(gene name)|psi-mi:CDR2(display_short)|uniprotkb:PCD17(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515524|imex:IM-28561-1643	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	refseq:NP_001793.1|ensembl:ENSG00000140743(gene)|ensembl:ENST00000268383(transcript)|interpro:IPR026079|mint:Q01850|refseq:XP_005276559.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	rogid:TYCAl4weno3VU167nI6ARIiWQZY9606	rigid:yZdreQlV6oQavDroybtqtINCGro	false	sufficient binding region:720-1000	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q92574	uniprotkb:A6NC98	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	intact:EBI-347573|uniprotkb:B5MDM2|uniprotkb:A5D8Y5|uniprotkb:Q05BL2|uniprotkb:Q6RUV3|uniprotkb:Q8N1Q6|uniprotkb:Q8NF44|uniprotkb:Q9H0H1|intact:EBI-2802028|ensembl:ENSP00000349238	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:cc88b_human(display_long)|uniprotkb:CCDC88B(gene name)|psi-mi:CCDC88B(display_short)|uniprotkb:BRLZ(gene name synonym)|uniprotkb:Brain leucine zipper domain-containing protein(gene name synonym)|uniprotkb:Hook-related protein 3(gene name synonym)|uniprotkb:Gipie(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515515|imex:IM-28561-717	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	refseq:NP_115627.6|ensembl:ENSG00000168071(gene)|ensembl:ENST00000356786(transcript)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0008017"(microtubule binding)|go:"GO:0016020"(membrane)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051959"(dynein light intermediate chain binding)|interpro:IPR036872|interpro:IPR043936	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	rogid:s3J2pQABqQHFONLVjshSCCTTmSc9606	rigid:ms5p+eiCmCbLVpK+2khYh6Sl+qQ	false	sufficient binding region:720-1000	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q92574	uniprotkb:O15234	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	intact:EBI-299118|ensembl:ENSP00000264645|uniprotkb:A8K8R0	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:casc3_human(display_long)|uniprotkb:CASC3(gene name)|psi-mi:CASC3(display_short)|uniprotkb:MLN51(gene name synonym)|uniprotkb:Cancer susceptibility candidate gene 3 protein(gene name synonym)|uniprotkb:Metastatic lymph node gene 51 protein(gene name synonym)|uniprotkb:Protein barentsz(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515506|imex:IM-28561-273	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	go:"GO:0008298"(intracellular mRNA localization)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0030425"(dendrite)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035145"(exon-exon junction complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051028"(mRNA transport)|go:"GO:0071006"(U2-type catalytic step 1 spliceosome)|interpro:IPR018545|interpro:IPR028544|ensembl:ENSG00000108349(gene)|ensembl:ENST00000264645(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006417"(regulation of translation)|rcsb pdb:2HYI|rcsb pdb:2J0Q|rcsb pdb:2J0S|rcsb pdb:2J0U|rcsb pdb:2XB2|rcsb pdb:3EX7|rcsb pdb:5XJC|rcsb pdb:5YZG|rcsb pdb:6ICZ|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72187|reactome:R-HSA-73856|reactome:R-HSA-9010553|reactome:R-HSA-975957|refseq:NP_031385.2|refseq:XP_005257220.1|dip:DIP-33288N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	rogid:62nwK5KCrjsyaY7WKPlfUAPhohM9606	rigid:UMjn1ellO9LuSqHhjy65JH8hYrY	false	sufficient binding region:720-1000	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q92574	uniprotkb:Q13137	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	intact:EBI-739580|uniprotkb:B4DDC4|uniprotkb:E7ENK0|uniprotkb:Q53FQ5|uniprotkb:Q53HB5|uniprotkb:Q6IBN9|uniprotkb:Q9BTF7|uniprotkb:B2RBT0|ensembl:ENSP00000258947|uniprotkb:B4E0C0|uniprotkb:E7ETP5|uniprotkb:B4DDT4|uniprotkb:B4DP36|uniprotkb:E9PBE5	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:caco2_human(display_long)|uniprotkb:CALCOCO2(gene name)|psi-mi:CALCOCO2(display_short)|uniprotkb:NDP52(gene name synonym)|uniprotkb:Nuclear domain 10 protein NDP52(gene name synonym)|uniprotkb:Antigen nuclear dot 52 kDa protein(gene name synonym)|uniprotkb:Nuclear dot protein 52(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515497|imex:IM-28561-1145	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	refseq:NP_001248319.1|refseq:NP_001248320.1|refseq:NP_001248322.1|refseq:NP_005822.1|ensembl:ENSG00000136436(gene)|ensembl:ENST00000258947(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016032"(viral process)|go:"GO:0016605"(PML body)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0098792"(xenophagy)|go:"GO:1901098"(positive regulation of autophagosome maturation)|interpro:IPR041611|interpro:IPR041641|mint:Q13137|rcsb pdb:2MXP|rcsb pdb:3VVV|rcsb pdb:3VVW|rcsb pdb:4GXL|rcsb pdb:4HAN|rcsb pdb:4XKL|rcsb pdb:5AAQ|rcsb pdb:5Z7A|rcsb pdb:5Z7L|refseq:NP_001248324.1|dip:DIP-57534N	-	-	crc64:609B121DA1A9DCB8	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	rogid:N/GPJUGBK+Dh5Cg+csmafphuo9M9606	rigid:Cri6Tqp/bXfJ0tY0CdECFuLdSH0	false	sufficient binding region:720-1000	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q96H12	uniprotkb:Q92574	intact:EBI-8466227|uniprotkb:Q5T728|uniprotkb:Q5T726|uniprotkb:Q5T727|intact:MINT-7032147|uniprotkb:B2RC35|ensembl:ENSP00000378506|ensembl:ENSP00000480445|ensembl:ENSP00000480622	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	psi-mi:msd3_human(display_long)|uniprotkb:MSANTD3(gene name)|psi-mi:MSANTD3(display_short)|uniprotkb:C9orf30(gene name synonym)|uniprotkb:L8(orf name)	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515488|imex:IM-28561-79	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001185735.1|refseq:NP_001185734.1|refseq:NP_542386.1|refseq:NP_001185736.1|ensembl:ENSG00000066697(gene)|ensembl:ENST00000395067(transcript)|ensembl:ENST00000613183(transcript)|ensembl:ENST00000622639(transcript)|interpro:IPR026709|interpro:IPR028002|mint:Q96H12	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	-	comment:mint|comment:homomint	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:JOWl9WQVA131ZH45W9BYNpdEAJU9606	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	rigid:fD/Zy4pVyBttT4kO4luq+Oyc1Fs	false	-	sufficient binding region:720-1000	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q92574	uniprotkb:Q9H9L4	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	intact:EBI-2560840|uniprotkb:Q8N3B5|uniprotkb:Q9NX51|uniprotkb:Q96CV0|ensembl:ENSP00000415436	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:kanl2_human(display_long)|uniprotkb:KANSL2(gene name)|psi-mi:KANSL2(display_short)|uniprotkb:C12orf41(gene name synonym)|uniprotkb:NSL complex protein NSL2(gene name synonym)|uniprotkb:NSL2(gene name synonym)|uniprotkb:Non-specific lethal 2 homolog(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515479|imex:IM-28561-485	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	refseq:NP_060292.3|ensembl:ENSG00000139620(gene)|ensembl:ENST00000420613(transcript)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0043981"(histone H4-K5 acetylation)|go:"GO:0043982"(histone H4-K8 acetylation)|go:"GO:0043984"(histone H4-K16 acetylation)|go:"GO:0044545"(NSL complex)|interpro:IPR025927|interpro:IPR026316|mint:Q9H9L4|rcsb pdb:4CY2|reactome:R-HSA-3214847	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	rogid:ymOXqnaeH6HuGcHPg4R2XVmWAz89606	rigid:uzlVrz33cPwFRezLzqST/cK6Iac	false	sufficient binding region:720-1000	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q92574	uniprotkb:Q7L4P6	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	intact:EBI-724373|ensembl:ENSP00000360899|uniprotkb:D3DQ27|uniprotkb:Q96A62|uniprotkb:Q9HAI3|intact:EBI-3044085	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:bend5_human(display_long)|uniprotkb:BEND5(gene name)|psi-mi:BEND5(display_short)|uniprotkb:C1orf165(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515470|imex:IM-28561-715	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	refseq:NP_078879.2|ensembl:ENSG00000162373(gene)|ensembl:ENST00000371833(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR018379|interpro:IPR040391|mint:Q7L4P6|refseq:NP_001289011.1|refseq:XP_011540444.1|refseq:XP_016857823.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	rogid:R6OwgNU76FX6tqLRdHVmzEgK8EE9606	rigid:IkLu+mxhLWMxbd1jFdnpf5Qk29o	false	sufficient binding region:720-1000	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q92574	uniprotkb:Q9H165	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	intact:EBI-765567|uniprotkb:Q86W14|uniprotkb:Q8WU92|uniprotkb:Q96JL6|uniprotkb:Q9H163|uniprotkb:Q9H164|uniprotkb:Q9H3G9|uniprotkb:Q9NWA7|uniprotkb:D6W5D7|uniprotkb:Q66LN6|ensembl:ENSP00000496168	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:bc11a_human(display_long)|uniprotkb:B-cell CLL/lymphoma 11A(gene name synonym)|uniprotkb:COUP-TF-interacting protein 1(gene name synonym)|uniprotkb:Ecotropic viral integration site 9 protein homolog(gene name synonym)|uniprotkb:BCL11A(gene name)|psi-mi:BCL11A(display_short)|uniprotkb:CTIP1(gene name synonym)|uniprotkb:EVI9(gene name synonym)|uniprotkb:KIAA1809(gene name synonym)|uniprotkb:ZNF856(gene name synonym)|uniprotkb:Zinc finger protein 856(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515461|imex:IM-28561-1417	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	refseq:NP_060484.2|refseq:NP_075044.2|refseq:NP_612569.1|refseq:XP_011531211.1|refseq:XP_016859823.1|dip:DIP-45629N|ensembl:ENSG00000119866(gene)|ensembl:ENST00000642384(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001067"(transcription regulatory region nucleic acid binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0032463"(negative regulation of protein homooligomerization)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048671"(negative regulation of collateral sprouting)|go:"GO:0048672"(positive regulation of collateral sprouting)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:1903860"(negative regulation of dendrite extension)|go:"GO:1904800"(negative regulation of neuron remodeling)|go:"GO:1905232"(cellular response to L-glutamate)|go:"GO:2000171"(negative regulation of dendrite development)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:Q9H165|rcsb pdb:5VTB|rcsb pdb:6KI6|rcsb pdb:6U9Q|go:"GO:2000173"(negative regulation of branching morphogenesis of a nerve)	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	rogid:xASsLQWykg/7ZpyjLsQP8GlQ/H09606	rigid:K/5S0kOKEYx1nS/lol8nyybEA+E	false	sufficient binding region:720-1000	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q92574	uniprotkb:O15169	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	intact:EBI-710484|uniprotkb:Q4TT26|uniprotkb:Q4TT27|ensembl:ENSP00000262320|uniprotkb:Q86YA7|uniprotkb:Q8WVW6|uniprotkb:Q96S28	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:axin1_human(display_long)|uniprotkb:Axis inhibition protein 1(gene name synonym)|uniprotkb:AXIN1(gene name)|psi-mi:AXIN1(display_short)|uniprotkb:AXIN(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515452|imex:IM-28561-77	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	refseq:NP_003493.1|refseq:NP_851393.1|ensembl:ENSG00000103126(gene)|ensembl:ENST00000262320(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034622"|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046332"(SMAD binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0071944"(cell periphery)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR001158(DIX)|interpro:IPR014936(Axin beta-catenin binding)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR029071|interpro:IPR029797|interpro:IPR032101|interpro:IPR036305|interpro:IPR038207|interpro:IPR043581|mint:O15169|rcsb pdb:1DK8|rcsb pdb:1EMU|rcsb pdb:1O9U|rcsb pdb:3ZDI|rcsb pdb:4B7T|rcsb pdb:4NM0|rcsb pdb:4NM3|rcsb pdb:4NM5|rcsb pdb:4NM7|rcsb pdb:4NU1|rcsb pdb:5WZZ|rcsb pdb:6JCK|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-201681|reactome:R-HSA-4641257|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5689880|reactome:R-HSA-8931987|reactome:R-HSA-8939256|reactome:R-HSA-9018519|dip:DIP-34630N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	rogid:uO+LxY/7ibIZqdd5onbfXqGAZeo9606	rigid:hlmH8TvsEZJTRW5BaUqtGq31zEg	false	sufficient binding region:720-1000	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q92574	uniprotkb:Q86UU1	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	intact:EBI-4289858|uniprotkb:Q4KMF8|uniprotkb:Q8TEQ2|uniprotkb:O75133|uniprotkb:B0YJ63|uniprotkb:B0YJ64|intact:EBI-28975144|ensembl:ENSP00000354498|ensembl:ENSP00000469820	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:phlb1_human(display_long)|uniprotkb:PHLDB1(gene name)|psi-mi:PHLDB1(display_short)|uniprotkb:KIAA0638(gene name synonym)|uniprotkb:LL5A(gene name synonym)|uniprotkb:Protein LL5-alpha(gene name synonym)|uniprotkb:DLNB07(orf name)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515879|imex:IM-28561-1429	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	ensembl:ENST00000356063|ensembl:ENSP00000348359|ensembl:ENSP00000354498|ensembl:ENST00000528594|ensembl:ENSP00000435520|ensembl:ENST00000530994|ensembl:ENSP00000431508|ensembl:ENSP00000469820|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR037810|mint:Q86UU1|ensembl:ENSG00000019144(gene)|ensembl:ENST00000361417(transcript)|ensembl:ENST00000600882(transcript)|go:"GO:0010470"(regulation of gastrulation)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0045180"(basal cortex)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:1904261"(positive regulation of basement membrane assembly involved in embryonic body morphogenesis)|interpro:IPR000253(Forkhead-associated)|interpro:IPR001849(Pleckstrin-like)|refseq:NP_001138230.1|refseq:NP_001138231.1|refseq:NP_055972.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	rogid:Za4UuXVuMr4gzY2kr8EadOf5hWA9606	rigid:3xuIimyHQ7IiWOgz0jQgCW7YMWk	false	sufficient binding region:720-1000	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q92574	uniprotkb:Q96F24	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	intact:EBI-2362014|uniprotkb:Q86UR2|uniprotkb:Q96NP6|uniprotkb:Q9H0S9|uniprotkb:Q9H2I2|uniprotkb:A6PW36|uniprotkb:B4DWS0|ensembl:ENSP00000277746	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:nrbf2_human(display_long)|uniprotkb:NRBF2(gene name)|psi-mi:NRBF2(display_short)|uniprotkb:COPR(gene name synonym)|uniprotkb:Comodulator of PPAR and RXR(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515870|imex:IM-28561-947	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	refseq:NP_110386.2|refseq:NP_001269334.1|ensembl:ENSG00000148572(gene)|ensembl:ENST00000277746(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0006914"(autophagy)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0043550"(regulation of lipid kinase activity)|interpro:IPR015056(Protein of unknown function DUF1875)|interpro:IPR033393|interpro:IPR039679|rcsb pdb:4ZEY|reactome:R-HSA-383280	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	rogid:PWt0/5LsBllvyqOhdHX0ulbq4mc9606	rigid:e+zpBz1Q6OfZtDjTwNtELg1GVT4	false	sufficient binding region:720-1000	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q969F2	uniprotkb:Q92574	intact:EBI-1538629|uniprotkb:Q96EK8|uniprotkb:Q9BSN0|ensembl:ENSP00000296849|ensembl:ENSP00000479003	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	psi-mi:nkd2_human(display_long)|uniprotkb:NKD2(gene name)|psi-mi:NKD2(display_short)	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515861|imex:IM-28561-505	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_149111.1|refseq:NP_001258011.1|ensembl:ENST00000274150|ensembl:ENSP00000274150|ensembl:ENSP00000296849|ensembl:ENST00000610777|ensembl:ENSP00000482896|ensembl:ENSP00000479003|dip:DIP-38642N|ensembl:ENSG00000145506(gene)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019838"(growth factor binding)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032036"(myosin heavy chain binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0048210"(Golgi vesicle fusion to target membrane)|ensembl:ENSG00000276920(gene)|ensembl:ENST00000296849(transcript)|ensembl:ENST00000616539(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0051117"(ATPase binding)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0071944"(cell periphery)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR040140|mint:Q969F2	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:kQxbG3sbnbXPkaywAkvN6ip1+Bw9606	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	rigid:/xIWhUAxc78lMRwv2MRrWka4z8o	false	-	sufficient binding region:720-1000	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q92574	uniprotkb:Q9Y2I6	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	intact:EBI-719716|uniprotkb:A6NJN0|uniprotkb:B3V9H6|uniprotkb:B7Z1V8|uniprotkb:Q8NE38|uniprotkb:Q9NQE3|intact:EBI-741715|uniprotkb:Q5JYP0|ensembl:ENSP00000278886	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:ninl_human(display_long)|uniprotkb:NINL(gene name)|psi-mi:NINL(display_short)|uniprotkb:KIAA0980(gene name synonym)|uniprotkb:NLP(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515852|imex:IM-28561-1651	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	refseq:NP_079452.3|refseq:NP_001305155.1|ensembl:ENSG00000101004(gene)|ensembl:ENST00000278886(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0034454"(microtubule anchoring at centrosome)|go:"GO:0045171"(intercellular bridge)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-8854518	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	rogid:NAG+S5iboAG+mjX9ISJ05gY2lJY9606	rigid:uDR/9u5ug/mKjL28qBS5k9WfHdc	false	sufficient binding region:720-1000	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q92574	uniprotkb:Q7Z6G3	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	intact:EBI-950070|ensembl:ENSP00000307449|uniprotkb:A2RRG3|uniprotkb:O75547|uniprotkb:Q6ZSK0|uniprotkb:H3BTW2	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:neca2_human(display_long)|uniprotkb:Neuronal calcium-binding protein 2(gene name synonym)|uniprotkb:Synaptotagmin-interacting protein 2(gene name synonym)|uniprotkb:NECAB2(gene name)|psi-mi:NECAB2(display_short)|uniprotkb:EFCBP2(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515843|imex:IM-28561-279	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	ensembl:ENSG00000103154(gene)|ensembl:ENST00000305202(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031687"(A2A adenosine receptor binding)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042984"(regulation of amyloid precursor protein biosynthetic process)|go:"GO:0060168"(positive regulation of adenosine receptor signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1904021"(negative regulation of G protein-coupled receptor internalization)|go:"GO:1905477"(positive regulation of protein localization to membrane)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR007138(Antibiotic biosynthesis monooxygenase)|interpro:IPR011008(Dimeric alpha-beta barrel)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR039862|mint:Q7Z6G3|refseq:NP_061938.2|refseq:NP_001316678.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	rogid:Op/JNOBupSCF1U3MCeNmJ6gUUrg9606	rigid:cp54xwa2gPv4d/tgU6R10LFeuxw	false	sufficient binding region:400-724	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q92574	uniprotkb:P03886	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	intact:EBI-1246156|uniprotkb:Q37523|uniprotkb:C0JKH6|ensembl:ENSP00000354687	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:nu1m_human(display_long)|uniprotkb:MT-ND1(gene name)|psi-mi:MT-ND1(display_short)|uniprotkb:MTND1(gene name synonym)|uniprotkb:NADH1(gene name synonym)|uniprotkb:ND1(gene name synonym)|uniprotkb:NADH dehydrogenase subunit 1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515834|imex:IM-28561-945	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	refseq:YP_003024026.1|ensembl:ENSG00000198888(gene)|ensembl:ENST00000361390(transcript)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0009060"(aerobic respiration)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0030425"(dendrite)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0033194"(response to hydroperoxide)|go:"GO:0042493"|go:"GO:0043025"(neuronal cell body)|interpro:IPR001694(Respiratory-chain NADH dehydrogenase, subunit 1)|interpro:IPR018086|mint:P03886|rcsb pdb:5XTC|rcsb pdb:5XTD|reactome:R-HSA-611105|reactome:R-HSA-6799198	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	rogid:AZoXs+VEdQPt/9D2lr+qBuwsZfA9606	rigid:4n7rSlCWc8lAh4wvRWrIh8SePSU	false	sufficient binding region:720-1000	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q92574	uniprotkb:P02686	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	intact:EBI-947410|uniprotkb:A4FU54|uniprotkb:Q15337|uniprotkb:Q15338|uniprotkb:Q15339|uniprotkb:A8MY86|uniprotkb:A8MYL4|uniprotkb:A6NI84|uniprotkb:Q15340|uniprotkb:Q59GX3|uniprotkb:Q65ZS4|uniprotkb:Q6AI64|uniprotkb:Q6FH37|uniprotkb:Q6FI04|uniprotkb:Q6PK23|uniprotkb:B3KY66|uniprotkb:B7ZKS2|uniprotkb:B7ZKS4|ensembl:ENSP00000348273|ensembl:ENSP00000462223	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:mbp_human(display_long)|uniprotkb:MBP(gene name)|psi-mi:MBP(display_short)|uniprotkb:Myelin A1 protein(gene name synonym)|uniprotkb:Myelin membrane encephalitogenic protein(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515825|imex:IM-28561-1427	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	refseq:NP_001020252.1|refseq:NP_001020261.1|refseq:NP_001020263.1|refseq:NP_001020271.1|refseq:NP_001020272.1|refseq:NP_002376.1|refseq:XP_016881269.1|dip:DIP-36624N|ensembl:ENSG00000197971(gene)|ensembl:ENST00000355994(transcript)|ensembl:ENST00000580402(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002020"(protease binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007417"(central nervous system development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008366"(axon ensheathment)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009986"(cell surface)|go:"GO:0019911"(structural constituent of myelin sheath)|go:"GO:0021762"(substantia nigra development)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033269"(internode region of axon)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0042552"(myelination)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043209"(myelin sheath)|go:"GO:0043218"(compact myelin)|go:"GO:0045202"(synapse)|go:"GO:0061024"(membrane organization)|go:"GO:0071944"(cell periphery)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000548(Myelin basic protein)|mint:P02686|rcsb pdb:1BX2|rcsb pdb:1FV1|rcsb pdb:1HQR|rcsb pdb:1K2D|rcsb pdb:1QCL|rcsb pdb:1YMM|rcsb pdb:1ZGL|reactome:R-HSA-9619665	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	rogid:ebDCekUqLVlpi0vmYj/WZjha+AQ9606	rigid:WfEFLU1i9TnQUebb+GjCn944i4Q	false	sufficient binding region:720-1000	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q92574	uniprotkb:Q9NS73	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	intact:EBI-741953|uniprotkb:Q86TZ2|uniprotkb:Q96AS5|uniprotkb:Q9BS93|uniprotkb:Q9NZE1|ensembl:ENSP00000399718	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:mbip1_human(display_long)|uniprotkb:MAPK upstream kinase-binding inhibitory protein(gene name synonym)|uniprotkb:MBIP(gene name)|psi-mi:MBIP(display_short)|uniprotkb:BM-015(orf name)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515816|imex:IM-28561-943	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	refseq:NP_001138363.1|refseq:NP_057670.2|ensembl:ENSG00000151332(gene)|ensembl:ENST00000416007(transcript)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005671"(obsolete Ada2/Gcn5/Ada3 transcription activator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0042802"(identical protein binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0046330"(positive regulation of JNK cascade)|interpro:IPR026062|mint:Q9NS73|reactome:R-HSA-3214847|go:"GO:0005654"(nucleoplasm)|refseq:NP_001295039.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	rogid:PjaEuab6wwOyGImpNYFZfQ+TUvU9606	rigid:yqiAfnvU9krrvGXf8wrjnVYGw00	false	sufficient binding region:720-1000	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q92574	uniprotkb:Q9BRK4	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	intact:EBI-741037|ensembl:ENSP00000359240|ensembl:ENSP00000359243|uniprotkb:Q8N3I0|uniprotkb:Q96J79|uniprotkb:Q96JL2|uniprotkb:B1AL14|uniprotkb:D3DR72	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:lzts2_human(display_long)|uniprotkb:Protein LAPSER1(gene name synonym)|uniprotkb:LZTS2(gene name)|psi-mi:LZTS2(display_short)|uniprotkb:KIAA1813(gene name synonym)|uniprotkb:LAPSER1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515807|imex:IM-28561-503	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	refseq:NP_115805.1|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030496"(midbody)|go:"GO:0031982"(vesicle)|go:"GO:0051013"(microtubule severing)|go:"GO:0051168"(nuclear export)|go:"GO:0051255"(spindle midzone assembly)|go:"GO:0060682"(primary ureteric bud growth)|go:"GO:0072197"(ureter morphogenesis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|interpro:IPR028597|mint:Q9BRK4|ensembl:ENSG00000107816(gene)|ensembl:ENST00000370220(transcript)|ensembl:ENST00000370223(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0008285"(negative regulation of cell population proliferation)|refseq:XP_016872269.1|refseq:NP_001305028.1|refseq:NP_001305029.1|refseq:NP_001305030.1|refseq:XP_005270279.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	rogid:OaMJmnmfm6JniKUJeyg7fS6zRcw9606	rigid:Tz0Fly1RupGwc8/7Sv6ILckYnG4	false	sufficient binding region:720-1000	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q92574	uniprotkb:Q9NQ29	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	intact:EBI-473747|uniprotkb:Q96S32|uniprotkb:Q9NPH4|uniprotkb:B8ZZ13|ensembl:ENSP00000293872	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:luc7l_human(display_long)|uniprotkb:SR+89(gene name synonym)|uniprotkb:Putative SR protein LUC7B1(gene name synonym)|uniprotkb:LUC7L(gene name)|psi-mi:LUC7L(display_short)|uniprotkb:LUC7L1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515798|imex:IM-28561-277	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	refseq:NP_001307155.1|refseq:NP_001317349.1|refseq:NP_060502.1|refseq:NP_958815.1|ensembl:ENSG00000007392(gene)|ensembl:ENST00000293872(transcript)|go:"GO:0003729"(mRNA binding)|go:"GO:0005685"(U1 snRNP)|go:"GO:0006376"(mRNA splice site selection)|go:"GO:0042802"(identical protein binding)|go:"GO:0071004"(U2-type prespliceosome)|interpro:IPR004882(LUC7 related)|mint:Q9NQ29	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	rogid:Hsl0VZTCTP6UrKlo/FHOVwZqCaw9606	rigid:ETSMHyJaIvOE+NF2+EtVwCZ1fuQ	false	sufficient binding region:720-1000	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q92574	uniprotkb:Q6UWE0	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	intact:EBI-720984|uniprotkb:Q5VVV0|uniprotkb:Q8NB40|uniprotkb:Q96GT5|uniprotkb:Q96MX5|uniprotkb:Q96MZ7|ensembl:ENSP00000300417|ensembl:ENSP00000322937|ensembl:ENSP00000362419|ensembl:ENSP00000502167	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:lrsm1_human(display_long)|uniprotkb:Leucine-rich repeat and sterile alpha motif-containing protein 1(gene name synonym)|uniprotkb:Tsg101-associated ligase(gene name synonym)|uniprotkb:LRSAM1(gene name)|psi-mi:LRSAM1(display_short)|uniprotkb:TAL(gene name synonym)|uniprotkb:UNQ6496/PRO21356(orf name)|uniprotkb:RING-type E3 ubiquitin transferase LRSAM1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515789|imex:IM-28561-499	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	refseq:NP_001005373.1|refseq:NP_001005374.1|refseq:NP_001177652.1|refseq:NP_612370.3|refseq:XP_016870772.1|ensembl:ENSG00000148356(gene)|ensembl:ENST00000300417(transcript)|ensembl:ENST00000323301(transcript)|ensembl:ENST00000373322(transcript)|ensembl:ENST00000675448(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030163"(protein catabolic process)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0046755"(viral budding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070086"(ubiquitin-dependent endocytosis)|go:"GO:1904417"(positive regulation of xenophagy)|go:"GO:2000786"(positive regulation of autophagosome assembly)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032675|mint:Q6UWE0|reactome:R-HSA-983168	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	rogid:qkwPqOsfNjZBB2Xp6YAA9FbEZxM9606	rigid:k1HCNjBhmwDiyZA3RxRz2LDxhyE	false	sufficient binding region:720-1000	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q92574	uniprotkb:A6NGH7	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	intact:EBI-26515767|ensembl:ENSP00000359845|ensembl:ENSP00000427951	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:cc160_human(display_long)|uniprotkb:CCDC160(gene name)|psi-mi:CCDC160(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515780|imex:IM-28561-497	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	ensembl:ENSG00000203952(gene)|ensembl:ENST00000370809(transcript)|ensembl:ENST00000517294(transcript)|interpro:IPR026789|refseq:NP_001094827.1|refseq:XP_005262466.1|refseq:XP_005262467.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	rogid:uADIo0kYriEPyE3rIIQSJkrijII9606	rigid:MthvwJ8RYmY9ZOGKXkyWx84KYLg	false	sufficient binding region:720-1000	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q92574	uniprotkb:Q9NSK0	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	intact:EBI-949319|intact:EBI-28986540|ensembl:ENSP00000340221|ensembl:ENSP00000377620|ensembl:ENSP00000418031|uniprotkb:Q66K28|uniprotkb:B3KPI3|uniprotkb:B3KSQ3|uniprotkb:B3KNY4|uniprotkb:B4DME9|uniprotkb:Q96EG6	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:klc4_human(display_long)|uniprotkb:Kinesin-like protein 8(gene name synonym)|uniprotkb:KLC4(gene name)|psi-mi:KLC4(display_short)|uniprotkb:KNSL8(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515758|imex:IM-28561-495	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	ensembl:ENSG00000137171(gene)|ensembl:ENST00000347162(transcript)|ensembl:ENST00000394056(transcript)|ensembl:ENST00000479388(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|interpro:IPR002151(Kinesin light chain)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR015792(Kinesin light chain repeat)|interpro:IPR019734|reactome:R-HSA-2132295|reactome:R-HSA-5625970|reactome:R-HSA-6811434|reactome:R-HSA-983189|refseq:NP_612352.1|refseq:NP_958929.1|refseq:NP_958930.1|refseq:NP_958931.1|refseq:NP_001275963.1|refseq:NP_001275964.1|ensembl:ENST00000259708|ensembl:ENSP00000259708|ensembl:ENSP00000340221|ensembl:ENSP00000377620|ensembl:ENST00000453940|ensembl:ENSP00000395806|ensembl:ENST00000458460|ensembl:ENSP00000410358|ensembl:ENST00000467906|ensembl:ENSP00000418759|ensembl:ENSP00000418031	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	rogid:8wcjm5q5W1xiMTe50m3hpL4jy609606	rigid:Tmmp9fdjNajt/tv+0a35Ow1MbCk	false	sufficient binding region:720-1000	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q92574	uniprotkb:Q07866	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	intact:EBI-721019|uniprotkb:F8VTM4|uniprotkb:Q7RTQ3|uniprotkb:Q86V77|uniprotkb:Q86V78|uniprotkb:Q86V79|uniprotkb:Q7RTM2|uniprotkb:Q7RTM3|uniprotkb:Q7RTM5|uniprotkb:Q7RTP9|uniprotkb:Q7RTQ5|uniprotkb:Q7RTQ6|uniprotkb:Q86SF5|uniprotkb:Q86TF5|uniprotkb:Q86V74|uniprotkb:Q86V75|uniprotkb:Q86V76|uniprotkb:Q96H62|uniprotkb:A6NF62|intact:EBI-28976313|ensembl:ENSP00000341154	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:klc1_human(display_long)|uniprotkb:KLC1(gene name)|psi-mi:KLC1(display_short)|uniprotkb:KLC(gene name synonym)|uniprotkb:KNS2(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515749|imex:IM-28561-1425	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	refseq:NP_001123579.1|refseq:NP_005543.2|refseq:NP_891553.2|ensembl:ENST00000452929|ensembl:ENSP00000414982|ensembl:ENST00000553286|ensembl:ENSP00000452487|ensembl:ENST00000246489|ensembl:ENSP00000246489|ensembl:ENST00000334553|ensembl:ENST00000554228|ensembl:ENSP00000450616|ensembl:ENST00000557450|ensembl:ENSP00000450648|ensembl:ENST00000634686|ensembl:ENSP00000488938|ensembl:ENSP00000334523|ensembl:ENST00000347839|ensembl:ENSP00000334618|ensembl:ENSP00000341154|ensembl:ENST00000389744|ensembl:ENSP00000374394|dip:DIP-40371N|ensembl:ENSG00000126214(gene)|ensembl:ENST00000348520(transcript)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0016020"(membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035617"(stress granule disassembly)|interpro:IPR002151(Kinesin light chain)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR015792(Kinesin light chain repeat)|interpro:IPR019734|mint:Q07866|rcsb pdb:3NF1|rcsb pdb:5OJ8|reactome:R-HSA-2132295|reactome:R-HSA-5625970|reactome:R-HSA-6811434|reactome:R-HSA-983189|go:"GO:0030426"(growth cone)	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	rogid:T7SJbB/PScRqj74O/NH4q1KU0YM9606	rigid:8OaAxgO08e8Br1Jg//6fKjXwAG0	false	sufficient binding region:720-1000	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q92574	uniprotkb:Q12840	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	intact:EBI-713468|uniprotkb:Q4LE26|ensembl:ENSP00000408979|uniprotkb:A6H8M5	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:kif5a_human(display_long)|uniprotkb:Neuronal kinesin heavy chain(gene name synonym)|uniprotkb:Kinesin heavy chain neuron-specific 1(gene name synonym)|uniprotkb:KIF5A(gene name)|psi-mi:KIF5A(display_short)|uniprotkb:NKHC1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515740|imex:IM-28561-493	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	ensembl:ENST00000455537(transcript)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007411"(axon guidance)|go:"GO:0008017"(microtubule binding)|go:"GO:0008574"(plus-end-directed microtubule motor activity)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019894"(kinesin binding)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0035253"(ciliary rootlet)|go:"GO:0043204"(perikaryon)|go:"GO:0045202"(synapse)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0098971"(anterograde dendritic transport of neurotransmitter receptor complex)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1990049"(retrograde neuronal dense core vesicle transport)|interpro:IPR001752(Kinesin, motor region)|interpro:IPR019821|interpro:IPR027417|interpro:IPR027640|interpro:IPR036961|mint:Q12840|rcsb pdb:4UXT|rcsb pdb:4UXY|rcsb pdb:4UY0|reactome:R-HSA-2132295|reactome:R-HSA-264876|reactome:R-HSA-5625970|reactome:R-HSA-6811434|reactome:R-HSA-983189|ensembl:ENSG00000155980(gene)|refseq:NP_004975.2|dip:DIP-37584N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	rogid:fvhe2vZFe1vN8SS4IPCMA5Nr7j09606	rigid:JEaB9ksyE/iOm0uJicx0AqHvp5U	false	sufficient binding region:720-1000	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q92574	uniprotkb:O43896	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	intact:EBI-1644048|uniprotkb:O75186|uniprotkb:Q5U618|uniprotkb:D3DTL6|ensembl:ENSP00000320821	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:kif1c_human(display_long)|uniprotkb:KIF1C(gene name)|psi-mi:KIF1C(display_short)|uniprotkb:KIAA0706(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515731|imex:IM-28561-1649	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	refseq:NP_006603.2|refseq:XP_005256481.1|dip:DIP-40376N|ensembl:ENSG00000129250(gene)|ensembl:ENST00000320785(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0008017"(microtubule binding)|go:"GO:0008574"(plus-end-directed microtubule motor activity)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1990048"(anterograde neuronal dense core vesicle transport)|go:"GO:1990049"(retrograde neuronal dense core vesicle transport)|interpro:IPR000253(Forkhead-associated)|interpro:IPR001752(Kinesin, motor region)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR019821|interpro:IPR027417|interpro:IPR027640|interpro:IPR032405|interpro:IPR036961|mint:O43896|rcsb pdb:2G1L|reactome:R-HSA-6811434|reactome:R-HSA-983189	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	rogid:AeG87fdDj70xFfsQCPuXA9iiubo9606	rigid:oYevZjgk9+SEdFe6K/E0YA9p5C0	false	sufficient binding region:720-1000	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q92574	uniprotkb:Q674X7	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	intact:EBI-949239|uniprotkb:B0QYQ0|uniprotkb:B1AK78|uniprotkb:Q5TGF1|uniprotkb:Q674X6|uniprotkb:Q6ZUD1|uniprotkb:Q8IYN7|uniprotkb:Q8N409|uniprotkb:Q9UIL2|uniprotkb:Q674X4|ensembl:ENSP00000365198|uniprotkb:Q9UPX4|uniprotkb:B1AJZ1	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:kazrn_human(display_long)|uniprotkb:KIAA1026(gene name synonym)|uniprotkb:HRIHFB2003(orf name)|uniprotkb:KAZN(gene name)|psi-mi:KAZN(display_short)|uniprotkb:KAZ(gene name synonym)|uniprotkb:C1orf196(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515722|imex:IM-28561-1647	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	ensembl:ENSG00000189337(gene)|ensembl:ENST00000376030(transcript)|go:"GO:0001533"(cornified envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0016607"(nuclear speck)|go:"GO:0030057"(desmosome)|go:"GO:0031424"(keratinization)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR037613|interpro:IPR037614|interpro:IPR037615|interpro:IPR037616|mint:Q674X7|reactome:R-HSA-6809371|refseq:NP_001017999.1|refseq:NP_001018000.1|refseq:NP_001018001.1|refseq:NP_056024.1|refseq:NP_963922.2|refseq:XP_016856260.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	rogid:Ai9moSFrBZMcWm4XWkk/vGzD5yE9606	rigid:GlJMXpGigRPf7WUbbttgfbIDyWQ	false	sufficient binding region:720-1000	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q92574	uniprotkb:Q05084	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	intact:EBI-1046751|uniprotkb:P78506|uniprotkb:Q13824|uniprotkb:A8K7U1|intact:EBI-3915169|uniprotkb:Q96HG3|uniprotkb:B3FTQ2|ensembl:ENSP00000379908|ensembl:ENSP00000385570|ensembl:ENSP00000385651	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:ica69_human(display_long)|uniprotkb:69 kDa islet cell autoantigen(gene name synonym)|uniprotkb:Islet cell autoantigen p69(gene name synonym)|uniprotkb:ICA1(gene name)|psi-mi:ICA1(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515713|imex:IM-28561-491	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	refseq:NP_001129492.1|refseq:NP_004959.2|refseq:NP_071682.1|refseq:XP_011513647.1|refseq:XP_011513648.1|refseq:XP_011513649.1|refseq:XP_011513650.1|refseq:XP_011513651.1|refseq:NP_001263407.1|refseq:XP_005249792.1|ensembl:ENSG00000003147(gene)|ensembl:ENST00000396675(transcript)|ensembl:ENST00000402384(transcript)|ensembl:ENST00000406470(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006836"(neurotransmitter transport)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051049"(regulation of transport)|go:"GO:0140090"(membrane curvature sensor activity)|interpro:IPR006723(Islet cell autoantigen ICA69 homologue)|interpro:IPR010504(Arfaptin-like)|interpro:IPR024114|interpro:IPR027267|interpro:IPR030796|mint:Q05084|go:"GO:0019904"(protein domain specific binding)|refseq:XP_016867606.1|refseq:XP_016867607.1|refseq:XP_016867608.1|refseq:XP_016867609.1|refseq:XP_016867610.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	rogid:pVUULpiv0K4iNKkaK448C2ubSDo9606	rigid:ROZ9Vug7vDw3SsSfq9npczmQexM	false	sufficient binding region:720-1000	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q92574	uniprotkb:Q96ED9	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	intact:EBI-743290|uniprotkb:O60562|ensembl:ENSP00000380785	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:hook2_human(display_long)|uniprotkb:HOOK2(gene name)|psi-mi:HOOK2(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515704|imex:IM-28561-1153	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	refseq:NP_001093646.1|refseq:NP_037444.2|ensembl:ENSG00000095066(gene)|ensembl:ENST00000397668(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006897"(endocytosis)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0008017"(microtubule binding)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0015031"(protein transport)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0051959"(dynein light intermediate chain binding)|go:"GO:0070695"(FHF complex)|go:"GO:1905719"(protein localization to perinuclear region of cytoplasm)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR008636(HOOK)|interpro:IPR036872|interpro:IPR043936|mint:Q96ED9	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	rogid:ryVqr8ZYjAc5SuoRR/zMQxnh0O89606	rigid:ndiMSmS4W7w4FhGDxA7r4vmpXoM	false	sufficient binding region:720-1000	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q92574	uniprotkb:Q9NSC5	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	intact:EBI-748420|uniprotkb:O14580|uniprotkb:O95350|uniprotkb:Q9NSB9|uniprotkb:Q9NSC0|intact:EBI-2557809|uniprotkb:E9PCW9|uniprotkb:Q9NSC1|intact:EBI-28972925|ensembl:ENSP00000376162|ensembl:ENSP00000439937|ensembl:ENSP00000446026|intact:EBI-10175777|uniprotkb:B2RA10	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:home3_human(display_long)|uniprotkb:HOMER3(gene name)|psi-mi:HOMER3(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515695|imex:IM-28561-275	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	ensembl:ENST00000221222|ensembl:ENSP00000221222|ensembl:ENSP00000376162|ensembl:ENST00000433218|ensembl:ENSP00000396154|ensembl:ENSP00000439937|ensembl:ENSP00000446026|ensembl:ENST00000594439|ensembl:ENSP00000471835|refseq:XP_006723006.1|refseq:XP_006723007.1|refseq:NP_001139193.1|refseq:NP_001139194.1|refseq:NP_004829.3|refseq:NP_001139196.1|ensembl:ENSG00000051128(gene)|ensembl:ENST00000392351(transcript)|ensembl:ENST00000539827(transcript)|ensembl:ENST00000542541(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006605"(protein targeting)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030425"(dendrite)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0035256"(G protein-coupled glutamate receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:2001256"(regulation of store-operated calcium entry)|interpro:IPR000697(EVH1)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR044100|mint:Q9NSC5|rcsb pdb:2P8V|rcsb pdb:3CVF|reactome:R-HSA-6794361	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	rogid:U1y/y52nnf7zQUCNQlqk7JDgXi49606	rigid:O+UaFUBdQ1vKYcVAQn0PLnZayr4	false	sufficient binding region:720-1000	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q92574	uniprotkb:P52272	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	intact:EBI-486809|uniprotkb:Q9Y492|uniprotkb:Q15584|uniprotkb:Q8WZ44|uniprotkb:Q96H56|uniprotkb:Q9BWL9|intact:EBI-28985795|ensembl:ENSP00000325376	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:hnrpm_human(display_long)|uniprotkb:HNRNPM(gene name)|psi-mi:HNRNPM(display_short)|uniprotkb:HNRPM(gene name synonym)|uniprotkb:NAGR1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515686|imex:IM-28561-1423	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	refseq:NP_005959.2|refseq:NP_112480.2|ensembl:ENSG00000099783(gene)|ensembl:ENST00000325495(transcript)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0016020"(membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0042382"(paraspeckles)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0071014"(post-mRNA release spliceosomal complex)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000815"(regulation of mRNA stability involved in response to oxidative stress)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR024666|interpro:IPR024667|interpro:IPR034990|interpro:IPR035979|mint:P52272|rcsb pdb:2DGV|rcsb pdb:2DH9|rcsb pdb:2DO0|rcsb pdb:2OT8|reactome:R-HSA-6803529|reactome:R-HSA-72163|reactome:R-HSA-72203|dip:DIP-29336N|ensembl:ENSP00000325376|ensembl:ENST00000348943|ensembl:ENSP00000325732	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	rogid:5FnCgrz0xltEkgw3yh70KP2jz5g9606	rigid:N1gNDaaiblZMupi2OQHTjTiuMSk	false	sufficient binding region:720-1000	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q92574	uniprotkb:O14964	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	intact:EBI-740220|uniprotkb:Q9NR36|ensembl:ENSP00000331201|ensembl:ENSP00000504106	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:hgs_human(display_long)|uniprotkb:Protein pp110(gene name synonym)|uniprotkb:Hrs(gene name synonym)|uniprotkb:HGS(gene name)|psi-mi:HGS(display_short)|uniprotkb:HRS(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515677|imex:IM-28561-1151	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	refseq:NP_004703.1|dip:DIP-29050N|ensembl:ENSG00000185359(gene)|ensembl:ENST00000329138(transcript)|ensembl:ENST00000676546(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0007165"(signal transduction)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010324"(membrane invagination)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0016197"(endosomal transport)|go:"GO:0016236"(macroautophagy)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0033565"(ESCRT-0 complex)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0036258"(multivesicular body assembly)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043405"(regulation of MAP kinase activity)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0097013"(phagocytic vesicle lumen)|go:"GO:1903543"(positive regulation of exosomal secretion)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR002014(VHS)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR008942(ENTH/VHS)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017073(Ubiquitin binding protein, Hrs/VPS27)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR024641|mint:O14964|rcsb pdb:2D3G|rcsb pdb:3F1I|rcsb pdb:3OBQ|rcsb pdb:3ZYQ|rcsb pdb:4AVX|reactome:R-HSA-182971|reactome:R-HSA-432720|reactome:R-HSA-5689880|reactome:R-HSA-6807004|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-9013420|reactome:R-HSA-917729|reactome:R-HSA-9635644|reactome:R-HSA-9636383|reactome:R-HSA-9706019	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	rogid:z/AnREuqEpyJ9/Zj6JFCJCJem1I9606	rigid:o4MyIi4cO8ENZI0lyJjV9EAALtc	false	sufficient binding region:720-1000	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q92574	uniprotkb:Q76N89	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	intact:EBI-949582|ensembl:ENSP00000379228|uniprotkb:O15036|uniprotkb:Q9HCC7|uniprotkb:A7E2X0|uniprotkb:A8MYS3|uniprotkb:B4DH42|intact:EBI-11059486	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:hecw1_human(display_long)|uniprotkb:HECT, C2 and WW domain-containing protein 1(gene name synonym)|uniprotkb:NEDD4-like E3 ubiquitin-protein ligase 1(gene name synonym)|uniprotkb:HECW1(gene name)|psi-mi:HECW1(display_short)|uniprotkb:KIAA0322(gene name synonym)|uniprotkb:NEDL1(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HECW1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515668|imex:IM-28561-941	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR032348|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|interpro:IPR037795|interpro:IPR040524|mint:Q76N89|rcsb pdb:3L4H|reactome:R-HSA-4641258|ensembl:ENSG00000002746(gene)|ensembl:ENST00000395891(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0061630"(ubiquitin protein ligase activity)|refseq:NP_055867.3|refseq:NP_001273988.1|refseq:XP_016867375.1|refseq:XP_016867378.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	rogid:iK0wuIJT5WCj76JVf435fZeARkc9606	rigid:zUpfda4qrm3fINBZLt+Dx9DPt9M	false	sufficient binding region:720-1000	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q92574	uniprotkb:Q9BRR8	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	intact:EBI-11328376|uniprotkb:Q8N3B7|uniprotkb:Q9NW94|uniprotkb:Q8IZV6|ensembl:ENSP00000170564	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:gptc1_human(display_long)|uniprotkb:GPATCH1(gene name)|psi-mi:GPATCH1(display_short)|uniprotkb:ECGP(gene name synonym)|uniprotkb:Evolutionarily conserved G-patch domain-containing protein(gene name synonym)|uniprotkb:GPATC1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515659|imex:IM-28561-735	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	refseq:NP_060495.2|ensembl:ENSG00000076650(gene)|ensembl:ENST00000170564(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0071013"(catalytic step 2 spliceosome)|interpro:IPR000467(D111/G-patch)|interpro:IPR011666(Protein of unknown function DUF1604)	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	rogid:z1imd0pKTek8jcPc3TkAUvSpSH49606	rigid:d3Himg9aHKdRdNDegaf5r/KXTuk	false	sufficient binding region:720-1000	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q92574	uniprotkb:Q08379	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	intact:EBI-618309|intact:EBI-28970132|ensembl:ENSP00000478799|uniprotkb:Q6GRM9|uniprotkb:Q9BRB0|uniprotkb:Q9NYF9|uniprotkb:A0A0C4DGS5|intact:EBI-11522202	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:goga2_human(display_long)|uniprotkb:GOLGA2(gene name)|psi-mi:GOLGA2(display_short)|uniprotkb:130 kDa cis-Golgi matrix protein(gene name synonym)|uniprotkb:GM130 autoantigen(gene name synonym)|uniprotkb:Golgin-95(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515650|imex:IM-28561-939	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	ensembl:ENSG00000167110(gene)|ensembl:ENST00000611957(transcript)|go:"GO:0000137"(Golgi cis cisterna)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000922"(spindle pole)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005874"(microtubule)|go:"GO:0006486"(protein glycosylation)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007030"(Golgi organization)|go:"GO:0007098"(centrosome cycle)|go:"GO:0008017"(microtubule binding)|go:"GO:0008356"(asymmetric cell division)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0015031"(protein transport)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0060050"(positive regulation of protein glycosylation)|go:"GO:0061676"(importin-alpha family protein binding)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090161"(Golgi ribbon formation)|go:"GO:0090166"(Golgi disassembly)|go:"GO:0090306"(meiotic spindle assembly)|go:"GO:0090307"(mitotic spindle assembly)|interpro:IPR024858|interpro:IPR043937|interpro:IPR043976|mint:Q08379|rcsb pdb:4REY|rcsb pdb:6IW8|rcsb pdb:6IWA|rcsb pdb:6K06|reactome:R-HSA-162658|reactome:R-HSA-204005|reactome:R-HSA-6807878|reactome:R-HSA-8862803|refseq:NP_004477.3|ensembl:ENSP00000478799|dip:DIP-34271N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	rogid:vIlRg4sJ2oBiARNnyerGMaVr5ZU9606	rigid:mVFeEjpN2jLdWMbgxuHptFu2OpY	false	sufficient binding region:720-1000	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q92574	uniprotkb:Q96CN9	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	intact:EBI-746252|uniprotkb:Q9H6N7|ensembl:ENSP00000318821	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:gcc1_human(display_long)|uniprotkb:Golgi coiled-coil protein 1(gene name synonym)|uniprotkb:GCC1(gene name)|psi-mi:GCC1(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515623|imex:IM-28561-1149	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	refseq:NP_078799.2|ensembl:ENSG00000179562(gene)|ensembl:ENST00000321407(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0031267"(small GTPase binding)|interpro:IPR000237(GRIP)|reactome:R-HSA-6811440|go:"GO:0000138"(Golgi trans cisterna)	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	rogid:SCI+peKjPIvl/HbUUpHGM++qiRE9606	rigid:euRfFiYDE+FllCdOXLiHdvSjzRk	false	sufficient binding region:720-1000	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P67809	uniprotkb:Q07021	intact:EBI-354065|uniprotkb:P16990|uniprotkb:P16991|uniprotkb:Q14972|uniprotkb:Q15325|uniprotkb:Q5FVF0|ensembl:ENSP00000361626	intact:EBI-347528|uniprotkb:Q2HXR8|uniprotkb:Q9NNY8|intact:EBI-15990352|ensembl:ENSP00000225698	psi-mi:ybox1_human(display_long)|uniprotkb:YBX1(gene name)|psi-mi:YBX1(display_short)|uniprotkb:YB1(gene name synonym)|uniprotkb:NSEP1(gene name synonym)|uniprotkb:Y-box transcription factor(gene name synonym)|uniprotkb:CCAAT-binding transcription factor I subunit A(gene name synonym)|uniprotkb:Enhancer factor I subunit A(gene name synonym)|uniprotkb:DNA-binding protein B(gene name synonym)|uniprotkb:Nuclease-sensitive element-binding protein 1(gene name synonym)	psi-mi:c1qbp_human(display_long)|uniprotkb:C1QBP(gene name)|psi-mi:C1QBP(display_short)|uniprotkb:GC1QBP(gene name synonym)|uniprotkb:HABP1(gene name synonym)|uniprotkb:SF2P32(gene name synonym)|uniprotkb:Glycoprotein gC1qBP(gene name synonym)|uniprotkb:Hyaluronan-binding protein 1(gene name synonym)|uniprotkb:Mitochondrial matrix protein p32(gene name synonym)|uniprotkb:p33(gene name synonym)|uniprotkb:ASF/SF2-associated protein p32(gene name synonym)|uniprotkb:gC1q-R protein(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26516223|imex:IM-28561-99	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004550.2|dip:DIP-29405N|go:"GO:0070934"(CRD-mediated mRNA stabilization)|go:"GO:0070937"(CRD-mediated mRNA stability complex)|go:"GO:0071204"(histone pre-mRNA 3'end processing complex)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990428"(miRNA transport)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002059(Cold-shock protein, DNA-binding)|interpro:IPR011129(Cold shock protein)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR019844|mint:P67809|rcsb pdb:1H95|rcsb pdb:5YTS|rcsb pdb:5YTT|rcsb pdb:5YTV|rcsb pdb:5YTX|rcsb pdb:6A6L|rcsb pdb:6KTC|rcsb pdb:6KUG|rcsb pdb:6LMR|rcsb pdb:6LMS|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-9017802|ensembl:ENSG00000065978(gene)|ensembl:ENST00000321358(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005689"(U12-type spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0008544"(epidermis development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035198"(miRNA binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0050658"(RNA transport)|go:"GO:0051020"(GTPase binding)|go:"GO:0051031"(tRNA transport)|go:"GO:0051154"(negative regulation of striated muscle cell differentiation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0062153"(C5-methylcytidine-containing RNA binding)	refseq:NP_001203.1|dip:DIP-31164N|ensembl:ENSG00000108561(gene)|ensembl:ENST00000225698(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005540"(hyaluronic acid binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006397"(mRNA processing)|go:"GO:0006915"(apoptotic process)|go:"GO:0006955"(immune response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0008494"(translation activator activity)|go:"GO:0009986"(cell surface)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0030449"(regulation of complement activation)|go:"GO:0030984"(kininogen binding)|go:"GO:0031690"(adrenergic receptor binding)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0039534"(negative regulation of MDA-5 signaling pathway)|go:"GO:0039536"(negative regulation of RIG-I signaling pathway)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0042256"(mature ribosome assembly)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050687"(negative regulation of defense response to virus)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070131"(positive regulation of mitochondrial translation)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0097177"(mitochondrial ribosome binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:2000510"(positive regulation of dendritic cell chemotaxis)|interpro:IPR003428(Mitochondrial glycoprotein)|interpro:IPR036561|mint:Q07021|rcsb pdb:1P32|rcsb pdb:3RPX|rcsb pdb:6SZW|reactome:R-HSA-111471|go:"GO:0005886"(plasma membrane)|reactome:R-HSA-8980692|reactome:R-HSA-9013106|reactome:R-HSA-9645722|reactome:R-HSA-140837	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:0/mAXOzokPlDByFFzGTP8bp9nqo9606	rogid:NfZ31HjbYZxd8UQKRXczhpc306E9606	rigid:E7b9uVLmANuCWhvRsvAgFZMnPsE	false	sufficient binding region:141-324	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q92574	uniprotkb:Q9NRD5	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	intact:EBI-79165|uniprotkb:O95906|ensembl:ENSP00000349465|ensembl:ENSP00000385205|intact:EBI-2622151|uniprotkb:B3KS52	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:pick1_human(display_long)|uniprotkb:PICK1(gene name)|psi-mi:PICK1(display_short)|uniprotkb:PRKCABP(gene name synonym)|uniprotkb:Protein kinase C-alpha-binding protein(gene name synonym)|uniprotkb:Protein interacting with C kinase 1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515891|imex:IM-28561-89	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	ensembl:ENSG00000100151(gene)|ensembl:ENST00000356976(transcript)|ensembl:ENST00000404072(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|refseq:NP_001034672.1|refseq:NP_001034673.1|refseq:NP_036539.1|go:"GO:0015844"(monoamine transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021782"(glial cell development)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0034315"(regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0034316"(negative regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0036294"(cellular response to decreased oxygen levels)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0043113"(receptor clustering)|go:"GO:0045161"(neuronal ion channel clustering)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051015"(actin filament binding)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0098842"(postsynaptic early endosome)|go:"GO:0140090"(membrane curvature sensor activity)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR010504(Arfaptin-like)|interpro:IPR027267|interpro:IPR030798|interpro:IPR036034|interpro:IPR037959|mint:Q9NRD5|rcsb pdb:2GZV|rcsb pdb:6AR4|rcsb pdb:6BJN|rcsb pdb:6BJO|reactome:R-HSA-202733|reactome:R-HSA-416993	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	rogid:qRx+eNG7We8Oe0SQOekqpJpn8zk9606	rigid:mopCK0XYik+QTRZEYXKxaVqYFN4	false	sufficient binding region:400-724	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q05086	uniprotkb:Q14566	intact:EBI-954357|ensembl:ENSP00000497594|uniprotkb:P78355|uniprotkb:Q93066|uniprotkb:Q9UEP4|uniprotkb:Q9UEP5|uniprotkb:Q9UEP6|uniprotkb:Q9UEP7|uniprotkb:Q9UEP8|uniprotkb:Q9UEP9|uniprotkb:A8K8Z9	intact:EBI-374900|uniprotkb:Q13504|uniprotkb:Q99859|uniprotkb:B2R6H2|ensembl:ENSP00000264156	psi-mi:ube3a_human(display_long)|uniprotkb:E6AP ubiquitin-protein ligase(gene name synonym)|uniprotkb:Oncogenic protein-associated protein E6-AP(gene name synonym)|uniprotkb:Human papillomavirus E6-associated protein(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-54(gene name synonym)|uniprotkb:UBE3A(gene name)|psi-mi:UBE3A(display_short)|uniprotkb:E6AP(gene name synonym)|uniprotkb:EPVE6AP(gene name synonym)|uniprotkb:HPVE6A(gene name synonym)|uniprotkb:HECT-type ubiquitin transferase E3A(gene name synonym)	psi-mi:mcm6_human(display_long)|uniprotkb:MCM6(gene name)|psi-mi:MCM6(display_short)|uniprotkb:p105MCM(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26516207|imex:IM-28561-959	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0060736"(prostate gland growth)|go:"GO:0061002"(negative regulation of dendritic spine morphogenesis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061743"(motor learning)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:1905528"(positive regulation of Golgi lumen acidification)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:2000058"(regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000569(HECT)|interpro:IPR017134(Ubiquitin-protein ligase E6-AP)|interpro:IPR032353|interpro:IPR035983|interpro:IPR042556|mint:Q05086|rcsb pdb:1C4Z|rcsb pdb:1D5F|rcsb pdb:1EQX|rcsb pdb:2KR1|rcsb pdb:4GIZ|rcsb pdb:4XR8|rcsb pdb:6SJV|rcsb pdb:6SLM|rcsb pdb:6TGK|rcsb pdb:6U19|reactome:R-HSA-983168|ensembl:ENSG00000114062(gene)|ensembl:ENST00000650110(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007420"(brain development)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032570"(response to progesterone)|go:"GO:0035037"(sperm entry)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0042220"(response to cocaine)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048511"(rhythmic process)|refseq:NP_000453.2|refseq:NP_570853.1|refseq:NP_570854.1|refseq:XP_016878033.1|refseq:XP_016878034.1|refseq:XP_011520296.1|refseq:XP_011520297.1|refseq:XP_016878035.1|refseq:XP_016878036.1|refseq:XP_016878037.1|refseq:XP_016878038.1|refseq:XP_016878039.1|dip:DIP-6002N|refseq:XP_005268324.1|refseq:XP_005268325.1|refseq:XP_005268326.1|refseq:XP_005268327.1|refseq:XP_005268328.1|refseq:XP_006720738.1|refseq:XP_006720739.1|refseq:XP_016878040.1|refseq:XP_016878041.1|refseq:XP_016878042.1|refseq:XP_016878043.1|refseq:XP_016878044.1	ensembl:ENST00000264156(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0042555"(MCM complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0071162"(CMG complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902969"(mitotic DNA replication)|ensembl:ENSG00000076003(gene)|reactome:R-HSA-68962|reactome:R-HSA-69052|interpro:IPR008049(MCM protein 6)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041024|interpro:IPR041562|interpro:IPR001208(MCM)|mint:Q14566|rcsb pdb:2KLQ|rcsb pdb:2LE8|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|refseq:NP_005906.2|dip:DIP-31727N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:w9T67+NDlHSd1tR+FgcX3LI1zpQ9606	rogid:gVpEwgfSwwxvP2T2CvCzIukthY49606	rigid:mD7AvBFAe3hk3U4ttqJvIgKQ3UM	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q05086	uniprotkb:P53779	intact:EBI-954357|ensembl:ENSP00000497594|uniprotkb:P78355|uniprotkb:Q93066|uniprotkb:Q9UEP4|uniprotkb:Q9UEP5|uniprotkb:Q9UEP6|uniprotkb:Q9UEP7|uniprotkb:Q9UEP8|uniprotkb:Q9UEP9|uniprotkb:A8K8Z9	intact:EBI-713543|uniprotkb:A6NFS3|uniprotkb:Q15707|uniprotkb:Q49AP1|uniprotkb:A6NG28|uniprotkb:B3KQ94|ensembl:ENSP00000424154|ensembl:ENSP00000492204|ensembl:ENSP00000492292|ensembl:ENSP00000492903|ensembl:ENSP00000493013|ensembl:ENSP00000493045|ensembl:ENSP00000493072|ensembl:ENSP00000493275|ensembl:ENSP00000493290|ensembl:ENSP00000493363|ensembl:ENSP00000493375|ensembl:ENSP00000493408|ensembl:ENSP00000493435|ensembl:ENSP00000493450	psi-mi:ube3a_human(display_long)|uniprotkb:E6AP ubiquitin-protein ligase(gene name synonym)|uniprotkb:Oncogenic protein-associated protein E6-AP(gene name synonym)|uniprotkb:Human papillomavirus E6-associated protein(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-54(gene name synonym)|uniprotkb:UBE3A(gene name)|psi-mi:UBE3A(display_short)|uniprotkb:E6AP(gene name synonym)|uniprotkb:EPVE6AP(gene name synonym)|uniprotkb:HPVE6A(gene name synonym)|uniprotkb:HECT-type ubiquitin transferase E3A(gene name synonym)	psi-mi:mk10_human(display_long)|uniprotkb:Stress-activated protein kinase JNK3(gene name synonym)|uniprotkb:c-Jun N-terminal kinase 3(gene name synonym)|uniprotkb:MAP kinase p49 3F12(gene name synonym)|uniprotkb:MAPK10(gene name)|psi-mi:MAPK10(display_short)|uniprotkb:JNK3(gene name synonym)|uniprotkb:JNK3A(gene name synonym)|uniprotkb:PRKM10(gene name synonym)|uniprotkb:Stress-activated protein kinase 1b(gene name synonym)|uniprotkb:SAPK1B(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26516200|imex:IM-28561-1179	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0060736"(prostate gland growth)|go:"GO:0061002"(negative regulation of dendritic spine morphogenesis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061743"(motor learning)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:1905528"(positive regulation of Golgi lumen acidification)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:2000058"(regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000569(HECT)|interpro:IPR017134(Ubiquitin-protein ligase E6-AP)|interpro:IPR032353|interpro:IPR035983|interpro:IPR042556|mint:Q05086|rcsb pdb:1C4Z|rcsb pdb:1D5F|rcsb pdb:1EQX|rcsb pdb:2KR1|rcsb pdb:4GIZ|rcsb pdb:4XR8|rcsb pdb:6SJV|rcsb pdb:6SLM|rcsb pdb:6TGK|rcsb pdb:6U19|reactome:R-HSA-983168|ensembl:ENSG00000114062(gene)|ensembl:ENST00000650110(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007420"(brain development)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032570"(response to progesterone)|go:"GO:0035037"(sperm entry)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0042220"(response to cocaine)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048511"(rhythmic process)|refseq:NP_000453.2|refseq:NP_570853.1|refseq:NP_570854.1|refseq:XP_016878033.1|refseq:XP_016878034.1|refseq:XP_011520296.1|refseq:XP_011520297.1|refseq:XP_016878035.1|refseq:XP_016878036.1|refseq:XP_016878037.1|refseq:XP_016878038.1|refseq:XP_016878039.1|dip:DIP-6002N|refseq:XP_005268324.1|refseq:XP_005268325.1|refseq:XP_005268326.1|refseq:XP_005268327.1|refseq:XP_005268328.1|refseq:XP_006720738.1|refseq:XP_006720739.1|refseq:XP_016878040.1|refseq:XP_016878041.1|refseq:XP_016878042.1|refseq:XP_016878043.1|refseq:XP_016878044.1	refseq:XP_006714331.1|refseq:XP_005263186.1|refseq:XP_005263187.1|refseq:XP_005263192.1|refseq:NP_002744.1|refseq:NP_620446.1|refseq:NP_620448.1|refseq:NP_001304996.1|refseq:NP_001304997.1|refseq:NP_001304998.1|refseq:XP_011530419.1|refseq:XP_011530420.1|refseq:XP_011530422.1|refseq:XP_011530423.1|refseq:XP_016863908.1|refseq:XP_016863909.1|refseq:XP_016863910.1|refseq:XP_016863912.1|refseq:XP_016863913.1|refseq:XP_016863914.1|refseq:XP_016863915.1|refseq:XP_016863918.1|refseq:XP_016863919.1|refseq:XP_016863920.1|refseq:XP_016863921.1|dip:DIP-1015N|ensembl:ENSG00000109339(gene)|ensembl:ENST00000515400(transcript)|ensembl:ENST00000515650(transcript)|ensembl:ENST00000638313(transcript)|ensembl:ENST00000641051(transcript)|ensembl:ENST00000641066(transcript)|ensembl:ENST00000641157(transcript)|ensembl:ENST00000641207(transcript)|ensembl:ENST00000641341(transcript)|ensembl:ENST00000641462(transcript)|ensembl:ENST00000641647(transcript)|ensembl:ENST00000641823(transcript)|ensembl:ENST00000641902(transcript)|ensembl:ENST00000641952(transcript)|ensembl:ENST00000641983(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004705"(JUN kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0009414"(response to water deprivation)|go:"GO:0009416"(response to light stimulus)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0048511"(rhythmic process)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0071474"(cellular hyperosmotic response)|go:"GO:0090398"(cellular senescence)|go:"GO:0098969"(neurotransmitter receptor transport to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008351(JNK MAP kinase)|interpro:IPR011009(Protein kinase-like)|mint:P53779|rcsb pdb:1JNK|rcsb pdb:1PMN|rcsb pdb:1PMU|rcsb pdb:1PMV|rcsb pdb:2B1P|rcsb pdb:2EXC|rcsb pdb:2O0U|rcsb pdb:2O2U|rcsb pdb:2OK1|rcsb pdb:2P33|rcsb pdb:2R9S|rcsb pdb:2WAJ|rcsb pdb:2ZDT|rcsb pdb:2ZDU|rcsb pdb:3CGF|rcsb pdb:3CGO|rcsb pdb:3DA6|rcsb pdb:3FI2|rcsb pdb:3FI3|rcsb pdb:3FV8|rcsb pdb:3G90|rcsb pdb:3G9L|rcsb pdb:3G9N|rcsb pdb:3KVX|rcsb pdb:3OXI|rcsb pdb:3OY1|rcsb pdb:3PTG|rcsb pdb:3RTP|rcsb pdb:3TTI|rcsb pdb:3TTJ|rcsb pdb:3V6R|rcsb pdb:3V6S|rcsb pdb:4H36|rcsb pdb:4H39|rcsb pdb:4H3B|rcsb pdb:4KKE|rcsb pdb:4KKG|rcsb pdb:4KKH|rcsb pdb:4U79|rcsb pdb:4W4V|rcsb pdb:4W4W|rcsb pdb:4W4X|rcsb pdb:4W4Y|rcsb pdb:4WHZ|rcsb pdb:4X21|rcsb pdb:4Y46|rcsb pdb:4Y5H|rcsb pdb:4Z9L|rcsb pdb:6EKD|rcsb pdb:6EMH|rcsb pdb:6EQ9|rcsb pdb:7KSI|rcsb pdb:7KSJ|rcsb pdb:7KSK|reactome:R-HSA-2559580|reactome:R-HSA-2871796|reactome:R-HSA-450321|reactome:R-HSA-450341	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:w9T67+NDlHSd1tR+FgcX3LI1zpQ9606	rogid:dzYzsLACbyCktFnxNeBXEf02BdA9606	rigid:DvaZsP5Hp9pXM/sygwfzVFYPBpo	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q05086	uniprotkb:O00423	intact:EBI-954357|ensembl:ENSP00000497594|uniprotkb:P78355|uniprotkb:Q93066|uniprotkb:Q9UEP4|uniprotkb:Q9UEP5|uniprotkb:Q9UEP6|uniprotkb:Q9UEP7|uniprotkb:Q9UEP8|uniprotkb:Q9UEP9|uniprotkb:A8K8Z9	intact:EBI-751327|uniprotkb:Q86U15|uniprotkb:Q8N536|uniprotkb:Q8N5C4|uniprotkb:Q8WWL6|ensembl:ENSP00000262233	psi-mi:ube3a_human(display_long)|uniprotkb:E6AP ubiquitin-protein ligase(gene name synonym)|uniprotkb:Oncogenic protein-associated protein E6-AP(gene name synonym)|uniprotkb:Human papillomavirus E6-associated protein(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-54(gene name synonym)|uniprotkb:UBE3A(gene name)|psi-mi:UBE3A(display_short)|uniprotkb:E6AP(gene name synonym)|uniprotkb:EPVE6AP(gene name synonym)|uniprotkb:HPVE6A(gene name synonym)|uniprotkb:HECT-type ubiquitin transferase E3A(gene name synonym)	psi-mi:emal1_human(display_long)|uniprotkb:EML1(gene name)|psi-mi:EML1(display_short)|uniprotkb:EMAP1(gene name synonym)|uniprotkb:EMAPL(gene name synonym)|uniprotkb:EMAPL1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26516191|imex:IM-28561-739	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0060736"(prostate gland growth)|go:"GO:0061002"(negative regulation of dendritic spine morphogenesis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061743"(motor learning)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:1905528"(positive regulation of Golgi lumen acidification)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:2000058"(regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000569(HECT)|interpro:IPR017134(Ubiquitin-protein ligase E6-AP)|interpro:IPR032353|interpro:IPR035983|interpro:IPR042556|mint:Q05086|rcsb pdb:1C4Z|rcsb pdb:1D5F|rcsb pdb:1EQX|rcsb pdb:2KR1|rcsb pdb:4GIZ|rcsb pdb:4XR8|rcsb pdb:6SJV|rcsb pdb:6SLM|rcsb pdb:6TGK|rcsb pdb:6U19|reactome:R-HSA-983168|ensembl:ENSG00000114062(gene)|ensembl:ENST00000650110(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007420"(brain development)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032570"(response to progesterone)|go:"GO:0035037"(sperm entry)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0042220"(response to cocaine)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048511"(rhythmic process)|refseq:NP_000453.2|refseq:NP_570853.1|refseq:NP_570854.1|refseq:XP_016878033.1|refseq:XP_016878034.1|refseq:XP_011520296.1|refseq:XP_011520297.1|refseq:XP_016878035.1|refseq:XP_016878036.1|refseq:XP_016878037.1|refseq:XP_016878038.1|refseq:XP_016878039.1|dip:DIP-6002N|refseq:XP_005268324.1|refseq:XP_005268325.1|refseq:XP_005268326.1|refseq:XP_005268327.1|refseq:XP_005268328.1|refseq:XP_006720738.1|refseq:XP_006720739.1|refseq:XP_016878040.1|refseq:XP_016878041.1|refseq:XP_016878042.1|refseq:XP_016878043.1|refseq:XP_016878044.1	refseq:NP_001008707.1|refseq:NP_004425.2|ensembl:ENSG00000066629(gene)|ensembl:ENST00000262233(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0007420"(brain development)|go:"GO:0008017"(microtubule binding)|go:"GO:0015631"(tubulin binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:1990023"(mitotic spindle midzone)|interpro:IPR001680(WD40 repeat)|interpro:IPR005108(HELP)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|mint:O00423|rcsb pdb:4CI8	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:w9T67+NDlHSd1tR+FgcX3LI1zpQ9606	rogid:hfGdCoFa3Miii6W/ozQuZ2cFiHs9606	rigid:bNZEl1PPS22Yg8XC95jB0s5HDqo	false	sufficient binding region:1-159	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q05086	uniprotkb:P20807	intact:EBI-954357|ensembl:ENSP00000497594|uniprotkb:P78355|uniprotkb:Q93066|uniprotkb:Q9UEP4|uniprotkb:Q9UEP5|uniprotkb:Q9UEP6|uniprotkb:Q9UEP7|uniprotkb:Q9UEP8|uniprotkb:Q9UEP9|uniprotkb:A8K8Z9	intact:EBI-5655000|ensembl:ENSP00000380349|uniprotkb:Q9Y5S6|uniprotkb:Q9Y5S7|uniprotkb:Q9BTU4|uniprotkb:A6H8K6|uniprotkb:Q7L4R0|uniprotkb:Q9BQC8	psi-mi:ube3a_human(display_long)|uniprotkb:E6AP ubiquitin-protein ligase(gene name synonym)|uniprotkb:Oncogenic protein-associated protein E6-AP(gene name synonym)|uniprotkb:Human papillomavirus E6-associated protein(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-54(gene name synonym)|uniprotkb:UBE3A(gene name)|psi-mi:UBE3A(display_short)|uniprotkb:E6AP(gene name synonym)|uniprotkb:EPVE6AP(gene name synonym)|uniprotkb:HPVE6A(gene name synonym)|uniprotkb:HECT-type ubiquitin transferase E3A(gene name synonym)	psi-mi:can3_human(display_long)|uniprotkb:CANP3(gene name synonym)|uniprotkb:CANPL3(gene name synonym)|uniprotkb:Calcium-activated neutral proteinase 3(gene name synonym)|uniprotkb:Calpain L3(gene name synonym)|uniprotkb:Calpain p94(gene name synonym)|uniprotkb:Muscle-specific calcium-activated neutral protease 3(gene name synonym)|uniprotkb:NCL1(gene name synonym)|uniprotkb:New calpain 1(gene name synonym)|uniprotkb:CAPN3(gene name)|psi-mi:CAPN3(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26516182|imex:IM-28561-957	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0060736"(prostate gland growth)|go:"GO:0061002"(negative regulation of dendritic spine morphogenesis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061743"(motor learning)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:1905528"(positive regulation of Golgi lumen acidification)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:2000058"(regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000569(HECT)|interpro:IPR017134(Ubiquitin-protein ligase E6-AP)|interpro:IPR032353|interpro:IPR035983|interpro:IPR042556|mint:Q05086|rcsb pdb:1C4Z|rcsb pdb:1D5F|rcsb pdb:1EQX|rcsb pdb:2KR1|rcsb pdb:4GIZ|rcsb pdb:4XR8|rcsb pdb:6SJV|rcsb pdb:6SLM|rcsb pdb:6TGK|rcsb pdb:6U19|reactome:R-HSA-983168|ensembl:ENSG00000114062(gene)|ensembl:ENST00000650110(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007420"(brain development)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032570"(response to progesterone)|go:"GO:0035037"(sperm entry)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0042220"(response to cocaine)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048511"(rhythmic process)|refseq:NP_000453.2|refseq:NP_570853.1|refseq:NP_570854.1|refseq:XP_016878033.1|refseq:XP_016878034.1|refseq:XP_011520296.1|refseq:XP_011520297.1|refseq:XP_016878035.1|refseq:XP_016878036.1|refseq:XP_016878037.1|refseq:XP_016878038.1|refseq:XP_016878039.1|dip:DIP-6002N|refseq:XP_005268324.1|refseq:XP_005268325.1|refseq:XP_005268326.1|refseq:XP_005268327.1|refseq:XP_005268328.1|refseq:XP_006720738.1|refseq:XP_006720739.1|refseq:XP_016878040.1|refseq:XP_016878041.1|refseq:XP_016878042.1|refseq:XP_016878043.1|refseq:XP_016878044.1	ensembl:ENSG00000092529(gene)|ensembl:ENST00000397163(transcript)|go:"GO:0003824"(catalytic activity)|go:"GO:0004198"(calcium-dependent cysteine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005622"(intracellular anatomical structure)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007517"(muscle organ development)|go:"GO:0008233"(peptidase activity)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0014718"(positive regulation of satellite cell activation involved in skeletal muscle regeneration)|go:"GO:0014850"(response to muscle activity)|go:"GO:0030016"(myofibril)|go:"GO:0030018"(Z disc)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030239"(myofibril assembly)|refseq:NP_000061.1|refseq:NP_077320.1|refseq:NP_775110.1|refseq:NP_775111.1|refseq:NP_775112.1|refseq:NP_775113.1|go:"GO:0030315"(T-tubule)|go:"GO:0031402"(sodium ion binding)|go:"GO:0031432"(titin binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045661"(regulation of myoblast differentiation)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051592"(response to calcium ion)|go:"GO:0055103"(ligase regulator activity)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061061"(muscle structure development)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070315"(G1 to G0 transition involved in cell differentiation)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071472"(cellular response to salt stress)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0097264"(self proteolysis)|go:"GO:1990092"(calcium-dependent self proteolysis)|interpro:IPR000169(Peptidase, cysteine peptidase active site)|interpro:IPR001300(Peptidase C2, calpain)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR022682|interpro:IPR022683|interpro:IPR022684|interpro:IPR029531|interpro:IPR033883|interpro:IPR036213|interpro:IPR038765|mint:P20807|rcsb pdb:1Y9V|rcsb pdb:4OKH|rcsb pdb:6BDT|rcsb pdb:6BGP|rcsb pdb:6BJD|rcsb pdb:6BKJ|reactome:R-HSA-1474228	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:w9T67+NDlHSd1tR+FgcX3LI1zpQ9606	rogid:niIxeCH+wcEYovZ1/3/zTO27bOU9606	rigid:hr/AgGuoHgYUB1ZT4xXhO/qHbfI	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49815	uniprotkb:Q5W0Q7	intact:EBI-396587|uniprotkb:O75275|uniprotkb:Q8TAZ1|uniprotkb:A7E2E2|uniprotkb:B4DIQ7|uniprotkb:B4DRN2|uniprotkb:Q4LE71|uniprotkb:C9J378|ensembl:ENSP00000219476|uniprotkb:B4DIL8|uniprotkb:B7Z2B8	intact:EBI-2513899|ensembl:ENSP00000255304|uniprotkb:Q8IYE8|uniprotkb:Q6AI45|uniprotkb:Q14109|uniprotkb:Q8IY30	psi-mi:tsc2_human(display_long)|uniprotkb:TSC2(gene name)|psi-mi:TSC2(display_short)|uniprotkb:Tuberous sclerosis 2 protein(gene name synonym)|uniprotkb:TSC4(gene name synonym)	psi-mi:uspl1_human(display_long)|uniprotkb:Ubiquitin-specific peptidase-like protein 1(gene name synonym)|uniprotkb:USPL1(gene name)|psi-mi:USPL1(display_short)|uniprotkb:C13orf22(gene name synonym)|uniprotkb:D13S106(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26516173|imex:IM-28561-1159	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000539.2|refseq:NP_001070651.1|refseq:NP_001107854.1|ensembl:ENSG00000103197(gene)|ensembl:ENST00000219476(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006897"(endocytosis)|go:"GO:0007507"(heart development)|go:"GO:0008104"(protein localization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|refseq:NP_001305756.1|refseq:NP_001305758.1|refseq:NP_001305760.1|refseq:NP_001305761.1|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043276"(anoikis)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:1901525"(negative regulation of mitophagy)|interpro:IPR000331(Rap/ran-GAP)|interpro:IPR003913(Tuberin)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018515|interpro:IPR024584|interpro:IPR027107|interpro:IPR035974|mint:P49815|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-198323|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674400|reactome:R-HSA-8854214|refseq:XP_005255586.2|refseq:XP_016879105.1	ensembl:ENSG00000132952(gene)|ensembl:ENST00000255304(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009301"(snRNA transcription)|go:"GO:0015030"(Cajal body)|go:"GO:0016926"(protein desumoylation)|go:"GO:0030576"(Cajal body organization)|go:"GO:0032183"(SUMO binding)|go:"GO:0070140"(SUMO-specific isopeptidase activity)|interpro:IPR028889|interpro:IPR028890|interpro:IPR029388|interpro:IPR033505|interpro:IPR038765|refseq:NP_005791.3|refseq:NP_001308461.1|refseq:NP_001308462.1|refseq:NP_001308463.1|refseq:XP_005266270.1|dip:DIP-47278N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:II0K3oybyrXfM4GEYMwV2ZyoWwE9606	rogid:k1f34cDGMScg/+VAP4YpR62Hrto9606	rigid:4vCThncZkL0pHtvU1/eziRqpCK8	false	sufficient binding region:1-410	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49815	uniprotkb:Q8WTU2	intact:EBI-396587|uniprotkb:O75275|uniprotkb:Q8TAZ1|uniprotkb:A7E2E2|uniprotkb:B4DIQ7|uniprotkb:B4DRN2|uniprotkb:Q4LE71|uniprotkb:C9J378|ensembl:ENSP00000219476|uniprotkb:B4DIL8|uniprotkb:B7Z2B8	intact:EBI-20722735|ensembl:ENSP00000275560|uniprotkb:Q2HIZ5|uniprotkb:Q6ZMG3|uniprotkb:Q96BF5	psi-mi:tsc2_human(display_long)|uniprotkb:TSC2(gene name)|psi-mi:TSC2(display_short)|uniprotkb:Tuberous sclerosis 2 protein(gene name synonym)|uniprotkb:TSC4(gene name synonym)	psi-mi:srb4d_human(display_long)|uniprotkb:Four scavenger receptor cysteine-rich domains-containing protein(gene name synonym)|uniprotkb:S4D-SRCRB(gene name synonym)|uniprotkb:SSC4D(gene name)|psi-mi:SSC4D(display_short)|uniprotkb:SRCRB4D(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26516164|imex:IM-28561-519	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000539.2|refseq:NP_001070651.1|refseq:NP_001107854.1|ensembl:ENSG00000103197(gene)|ensembl:ENST00000219476(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006897"(endocytosis)|go:"GO:0007507"(heart development)|go:"GO:0008104"(protein localization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|refseq:NP_001305756.1|refseq:NP_001305758.1|refseq:NP_001305760.1|refseq:NP_001305761.1|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043276"(anoikis)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:1901525"(negative regulation of mitophagy)|interpro:IPR000331(Rap/ran-GAP)|interpro:IPR003913(Tuberin)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018515|interpro:IPR024584|interpro:IPR027107|interpro:IPR035974|mint:P49815|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-198323|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674400|reactome:R-HSA-8854214|refseq:XP_005255586.2|refseq:XP_016879105.1	interpro:IPR001190(Speract/scavenger receptor)|interpro:IPR017448(Speract/scavenger receptor related)|interpro:IPR036772|ensembl:ENSG00000146700(gene)|ensembl:ENST00000275560(transcript)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0016020"(membrane)|refseq:NP_542782.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:II0K3oybyrXfM4GEYMwV2ZyoWwE9606	rogid:FnulMrTXfb92o1AC8HOEBWxDLxo9606	rigid:8RN0jD4zgpAx7oNQDS1x9HbhVsk	false	sufficient binding region:1-410	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49815	uniprotkb:Q8WWT9	intact:EBI-396587|uniprotkb:O75275|uniprotkb:Q8TAZ1|uniprotkb:A7E2E2|uniprotkb:B4DIQ7|uniprotkb:B4DRN2|uniprotkb:Q4LE71|uniprotkb:C9J378|ensembl:ENSP00000219476|uniprotkb:B4DIL8|uniprotkb:B7Z2B8	intact:EBI-12938720|intact:EBI-28972532|ensembl:ENSP00000279027|uniprotkb:B4DIR8|uniprotkb:E1P5U4|uniprotkb:F6WI18|uniprotkb:Q5JYC9|uniprotkb:Q5JYD0|uniprotkb:Q5JYD1|uniprotkb:Q5TCQ2|uniprotkb:Q8IVB1|uniprotkb:Q8N8K4|uniprotkb:Q96MM5|uniprotkb:Q9BR25|uniprotkb:Q9H1G1|uniprotkb:Q9H3W4|uniprotkb:Q9NQN5|uniprotkb:Q9NS04	psi-mi:tsc2_human(display_long)|uniprotkb:TSC2(gene name)|psi-mi:TSC2(display_short)|uniprotkb:Tuberous sclerosis 2 protein(gene name synonym)|uniprotkb:TSC4(gene name synonym)	psi-mi:s13a3_human(display_long)|uniprotkb:SLC13A3(gene name)|psi-mi:SLC13A3(display_short)|uniprotkb:NADC3(gene name synonym)|uniprotkb:"Na(+)/dicarboxylate cotransporter 3"(gene name synonym)|uniprotkb:SDCT2(gene name synonym)|uniprotkb:Sodium-dependent high-affinity dicarboxylate transporter 2(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26516155|imex:IM-28561-1459	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000539.2|refseq:NP_001070651.1|refseq:NP_001107854.1|ensembl:ENSG00000103197(gene)|ensembl:ENST00000219476(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006897"(endocytosis)|go:"GO:0007507"(heart development)|go:"GO:0008104"(protein localization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|refseq:NP_001305756.1|refseq:NP_001305758.1|refseq:NP_001305760.1|refseq:NP_001305761.1|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043276"(anoikis)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:1901525"(negative regulation of mitophagy)|interpro:IPR000331(Rap/ran-GAP)|interpro:IPR003913(Tuberin)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018515|interpro:IPR024584|interpro:IPR027107|interpro:IPR035974|mint:P49815|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-198323|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674400|reactome:R-HSA-8854214|refseq:XP_005255586.2|refseq:XP_016879105.1	ensembl:ENSP00000279027|ensembl:ENST00000290317|ensembl:ENSP00000290317|ensembl:ENST00000413164|ensembl:ENSP00000415852|ensembl:ENST00000472148|ensembl:ENSP00000420177|ensembl:ENST00000495082|ensembl:ENSP00000419621|go:"GO:0015137"(citrate transmembrane transporter activity)|go:"GO:0015139"(alpha-ketoglutarate transmembrane transporter activity)|go:"GO:0015141"(succinate transmembrane transporter activity)|go:"GO:0015362"("high-affinity sodium:dicarboxylate symporter activity")|go:"GO:0015746"(citrate transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0017153"("sodium:dicarboxylate symporter activity")|go:"GO:0034634"(glutathione transmembrane transporter activity)|go:"GO:0034775"(glutathione transmembrane transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071422"(succinate transmembrane transport)|go:"GO:0098656"(anion transmembrane transport)|go:"GO:0150104"(transport across blood-brain barrier)|interpro:IPR001898(Sodium/sulphate symporter)|reactome:R-HSA-433137|ensembl:ENSG00000158296(gene)|ensembl:ENST00000279027(transcript)|go:"GO:0005310"(dicarboxylic acid transmembrane transporter activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006835"(dicarboxylic acid transport)|refseq:NP_001011554.1|refseq:NP_001180268.1|refseq:NP_001180269.1|refseq:NP_073740.2	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:II0K3oybyrXfM4GEYMwV2ZyoWwE9606	rogid:7uxGCAkfTmdd3wiu0cQKA1vMxOA9606	rigid:e0wvKAncyfv5uXX6I4faIf3vTBs	false	sufficient binding region:1-410	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49815	uniprotkb:Q99574	intact:EBI-396587|uniprotkb:O75275|uniprotkb:Q8TAZ1|uniprotkb:A7E2E2|uniprotkb:B4DIQ7|uniprotkb:B4DRN2|uniprotkb:Q4LE71|uniprotkb:C9J378|ensembl:ENSP00000219476|uniprotkb:B4DIL8|uniprotkb:B7Z2B8	intact:EBI-2684390|uniprotkb:A8K217|uniprotkb:Q6AHZ4|uniprotkb:D3DNP1|ensembl:ENSP00000295777|ensembl:ENSP00000397373	psi-mi:tsc2_human(display_long)|uniprotkb:TSC2(gene name)|psi-mi:TSC2(display_short)|uniprotkb:Tuberous sclerosis 2 protein(gene name synonym)|uniprotkb:TSC4(gene name synonym)	psi-mi:neus_human(display_long)|uniprotkb:PI12(gene name synonym)|uniprotkb:Peptidase inhibitor 12(gene name synonym)|uniprotkb:Serpin I1(gene name synonym)|uniprotkb:SERPINI1(gene name)|psi-mi:SERPINI1(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26516146|imex:IM-28561-1439	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000539.2|refseq:NP_001070651.1|refseq:NP_001107854.1|ensembl:ENSG00000103197(gene)|ensembl:ENST00000219476(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006897"(endocytosis)|go:"GO:0007507"(heart development)|go:"GO:0008104"(protein localization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|refseq:NP_001305756.1|refseq:NP_001305758.1|refseq:NP_001305760.1|refseq:NP_001305761.1|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043276"(anoikis)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:1901525"(negative regulation of mitophagy)|interpro:IPR000331(Rap/ran-GAP)|interpro:IPR003913(Tuberin)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018515|interpro:IPR024584|interpro:IPR027107|interpro:IPR035974|mint:P49815|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-198323|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674400|reactome:R-HSA-8854214|refseq:XP_005255586.2|refseq:XP_016879105.1	refseq:NP_001116224.1|refseq:NP_005016.1|ensembl:ENSG00000163536(gene)|ensembl:ENST00000295777(transcript)|ensembl:ENST00000446050(transcript)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0007417"(central nervous system development)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0060205"(cytoplasmic vesicle lumen)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR023795|interpro:IPR023796|interpro:IPR036186|interpro:IPR042178|interpro:IPR042185|rcsb pdb:3F02|rcsb pdb:3F5N|rcsb pdb:3FGQ|refseq:XP_016862107.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:II0K3oybyrXfM4GEYMwV2ZyoWwE9606	rogid:iZ/87UarP7wUnaFhEtKjxOf1Q9o9606	rigid:H+AtySm1UeT0ftsa72RU3UVtvk4	false	sufficient binding region:1-410	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49815	uniprotkb:P08865	intact:EBI-396587|uniprotkb:O75275|uniprotkb:Q8TAZ1|uniprotkb:A7E2E2|uniprotkb:B4DIQ7|uniprotkb:B4DRN2|uniprotkb:Q4LE71|uniprotkb:C9J378|ensembl:ENSP00000219476|uniprotkb:B4DIL8|uniprotkb:B7Z2B8	intact:EBI-354112|uniprotkb:Q6NSD1|uniprotkb:Q6NXQ8|uniprotkb:Q86VC0|uniprotkb:P11085|uniprotkb:P12030|uniprotkb:Q16471|uniprotkb:Q6IPD1|uniprotkb:Q6IPD2|ensembl:ENSP00000346067	psi-mi:tsc2_human(display_long)|uniprotkb:TSC2(gene name)|psi-mi:TSC2(display_short)|uniprotkb:Tuberous sclerosis 2 protein(gene name synonym)|uniprotkb:TSC4(gene name synonym)	psi-mi:rssa_human(display_long)|uniprotkb:RPSA(gene name)|psi-mi:RPSA(display_short)|uniprotkb:LAMBR(gene name synonym)|uniprotkb:LAMR1(gene name synonym)|uniprotkb:Laminin receptor 1(gene name synonym)|uniprotkb:37/67 kDa laminin receptor(gene name synonym)|uniprotkb:Laminin-binding protein precursor p40(gene name synonym)|uniprotkb:Colon carcinoma laminin-binding protein(gene name synonym)|uniprotkb:NEM/1CHD4(gene name synonym)|uniprotkb:Multidrug resistance-associated protein MGr1-Ag(gene name synonym)|uniprotkb:37 kDa laminin receptor precursor(gene name synonym)|uniprotkb:67 kDa laminin receptor(gene name synonym)|uniprotkb:Small ribosomal subunit protein uS2(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26516137|imex:IM-28561-517	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000539.2|refseq:NP_001070651.1|refseq:NP_001107854.1|ensembl:ENSG00000103197(gene)|ensembl:ENST00000219476(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006897"(endocytosis)|go:"GO:0007507"(heart development)|go:"GO:0008104"(protein localization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|refseq:NP_001305756.1|refseq:NP_001305758.1|refseq:NP_001305760.1|refseq:NP_001305761.1|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043276"(anoikis)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:1901525"(negative regulation of mitophagy)|interpro:IPR000331(Rap/ran-GAP)|interpro:IPR003913(Tuberin)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018515|interpro:IPR024584|interpro:IPR027107|interpro:IPR035974|mint:P49815|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-198323|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674400|reactome:R-HSA-8854214|refseq:XP_005255586.2|refseq:XP_016879105.1	refseq:NP_002286.2|refseq:NP_001291217.1|dip:DIP-32878N|ensembl:ENSG00000168028(gene)|ensembl:ENST00000301821(transcript)|go:"GO:0000028"(ribosomal small subunit assembly)|go:"GO:0001618"(virus receptor activity)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005055"(laminin receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006412"(translation)|go:"GO:0007155"(cell adhesion)|rcsb pdb:6ZOK|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|rcsb pdb:6ZOJ|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|go:"GO:0016020"(membrane)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0043022"(ribosome binding)|go:"GO:0043236"(laminin binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001865(Ribosomal protein S2)|interpro:IPR005707(Ribosomal protein S2, eukaryotic/archaeal)|interpro:IPR018130|interpro:IPR023591|interpro:IPR027498|interpro:IPR027504|interpro:IPR032281|mint:P08865|rcsb pdb:3BCH|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBD|rcsb pdb:6YBW|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:II0K3oybyrXfM4GEYMwV2ZyoWwE9606	rogid:Jpv3I3G5C297fHfNwIqyB9Pf8/A9606	rigid:jSjaWFVJeJTQv0Dc93IwS/G0i+A	false	sufficient binding region:1-410	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49815	uniprotkb:P36578	intact:EBI-396587|uniprotkb:O75275|uniprotkb:Q8TAZ1|uniprotkb:A7E2E2|uniprotkb:B4DIQ7|uniprotkb:B4DRN2|uniprotkb:Q4LE71|uniprotkb:C9J378|ensembl:ENSP00000219476|uniprotkb:B4DIL8|uniprotkb:B7Z2B8	intact:EBI-348313|ensembl:ENSP00000311430|uniprotkb:P39029|uniprotkb:Q4VBR0|uniprotkb:Q969Z9|uniprotkb:A8K502	psi-mi:tsc2_human(display_long)|uniprotkb:TSC2(gene name)|psi-mi:TSC2(display_short)|uniprotkb:Tuberous sclerosis 2 protein(gene name synonym)|uniprotkb:TSC4(gene name synonym)	psi-mi:rl4_human(display_long)|uniprotkb:RPL4(gene name)|psi-mi:RPL4(display_short)|uniprotkb:RPL1(gene name synonym)|uniprotkb:60S ribosomal protein L1(gene name synonym)|uniprotkb:Large ribosomal subunit protein uL4(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26516128|imex:IM-28561-515	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000539.2|refseq:NP_001070651.1|refseq:NP_001107854.1|ensembl:ENSG00000103197(gene)|ensembl:ENST00000219476(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006897"(endocytosis)|go:"GO:0007507"(heart development)|go:"GO:0008104"(protein localization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|refseq:NP_001305756.1|refseq:NP_001305758.1|refseq:NP_001305760.1|refseq:NP_001305761.1|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043276"(anoikis)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:1901525"(negative regulation of mitophagy)|interpro:IPR000331(Rap/ran-GAP)|interpro:IPR003913(Tuberin)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018515|interpro:IPR024584|interpro:IPR027107|interpro:IPR035974|mint:P49815|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-198323|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674400|reactome:R-HSA-8854214|refseq:XP_005255586.2|refseq:XP_016879105.1	ensembl:ENSG00000174444(gene)|ensembl:ENST00000307961(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR002136(Ribosomal protein L4/L1e)|interpro:IPR013000(Ribosomal protein L4/L1e, eukaryotic/archaeal, conserved site)|interpro:IPR025755|mint:P36578|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A8L|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|interpro:IPR023574|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|rcsb pdb:6OM0|refseq:NP_000959.2|dip:DIP-27559N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:II0K3oybyrXfM4GEYMwV2ZyoWwE9606	rogid:34il/jyrW0Dqj0eA8GBFgUk05XU9606	rigid:7VqJLlI0+NgSgsLx8trQ+PQoN70	false	sufficient binding region:1-410	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49815	uniprotkb:Q9NRD5	intact:EBI-396587|uniprotkb:O75275|uniprotkb:Q8TAZ1|uniprotkb:A7E2E2|uniprotkb:B4DIQ7|uniprotkb:B4DRN2|uniprotkb:Q4LE71|uniprotkb:C9J378|ensembl:ENSP00000219476|uniprotkb:B4DIL8|uniprotkb:B7Z2B8	intact:EBI-79165|uniprotkb:O95906|ensembl:ENSP00000349465|ensembl:ENSP00000385205|intact:EBI-2622151|uniprotkb:B3KS52	psi-mi:tsc2_human(display_long)|uniprotkb:TSC2(gene name)|psi-mi:TSC2(display_short)|uniprotkb:Tuberous sclerosis 2 protein(gene name synonym)|uniprotkb:TSC4(gene name synonym)	psi-mi:pick1_human(display_long)|uniprotkb:PICK1(gene name)|psi-mi:PICK1(display_short)|uniprotkb:PRKCABP(gene name synonym)|uniprotkb:Protein kinase C-alpha-binding protein(gene name synonym)|uniprotkb:Protein interacting with C kinase 1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26516119|imex:IM-28561-955	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000539.2|refseq:NP_001070651.1|refseq:NP_001107854.1|ensembl:ENSG00000103197(gene)|ensembl:ENST00000219476(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006897"(endocytosis)|go:"GO:0007507"(heart development)|go:"GO:0008104"(protein localization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|refseq:NP_001305756.1|refseq:NP_001305758.1|refseq:NP_001305760.1|refseq:NP_001305761.1|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043276"(anoikis)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:1901525"(negative regulation of mitophagy)|interpro:IPR000331(Rap/ran-GAP)|interpro:IPR003913(Tuberin)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018515|interpro:IPR024584|interpro:IPR027107|interpro:IPR035974|mint:P49815|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-198323|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674400|reactome:R-HSA-8854214|refseq:XP_005255586.2|refseq:XP_016879105.1	ensembl:ENSG00000100151(gene)|ensembl:ENST00000356976(transcript)|ensembl:ENST00000404072(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|refseq:NP_001034672.1|refseq:NP_001034673.1|refseq:NP_036539.1|go:"GO:0015844"(monoamine transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021782"(glial cell development)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0034315"(regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0034316"(negative regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0036294"(cellular response to decreased oxygen levels)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0043113"(receptor clustering)|go:"GO:0045161"(neuronal ion channel clustering)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051015"(actin filament binding)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0098842"(postsynaptic early endosome)|go:"GO:0140090"(membrane curvature sensor activity)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR010504(Arfaptin-like)|interpro:IPR027267|interpro:IPR030798|interpro:IPR036034|interpro:IPR037959|mint:Q9NRD5|rcsb pdb:2GZV|rcsb pdb:6AR4|rcsb pdb:6BJN|rcsb pdb:6BJO|reactome:R-HSA-202733|reactome:R-HSA-416993	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:II0K3oybyrXfM4GEYMwV2ZyoWwE9606	rogid:qRx+eNG7We8Oe0SQOekqpJpn8zk9606	rigid:hOR6zGT+6IJwxyxKTfkayV348sQ	false	sufficient binding region:1-410	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49815	uniprotkb:Q86UU1	intact:EBI-396587|uniprotkb:O75275|uniprotkb:Q8TAZ1|uniprotkb:A7E2E2|uniprotkb:B4DIQ7|uniprotkb:B4DRN2|uniprotkb:Q4LE71|uniprotkb:C9J378|ensembl:ENSP00000219476|uniprotkb:B4DIL8|uniprotkb:B7Z2B8	intact:EBI-4289858|uniprotkb:Q4KMF8|uniprotkb:Q8TEQ2|uniprotkb:O75133|uniprotkb:B0YJ63|uniprotkb:B0YJ64|intact:EBI-28975144|ensembl:ENSP00000354498|ensembl:ENSP00000469820	psi-mi:tsc2_human(display_long)|uniprotkb:TSC2(gene name)|psi-mi:TSC2(display_short)|uniprotkb:Tuberous sclerosis 2 protein(gene name synonym)|uniprotkb:TSC4(gene name synonym)	psi-mi:phlb1_human(display_long)|uniprotkb:PHLDB1(gene name)|psi-mi:PHLDB1(display_short)|uniprotkb:KIAA0638(gene name synonym)|uniprotkb:LL5A(gene name synonym)|uniprotkb:Protein LL5-alpha(gene name synonym)|uniprotkb:DLNB07(orf name)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26516110|imex:IM-28561-1659	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000539.2|refseq:NP_001070651.1|refseq:NP_001107854.1|ensembl:ENSG00000103197(gene)|ensembl:ENST00000219476(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006897"(endocytosis)|go:"GO:0007507"(heart development)|go:"GO:0008104"(protein localization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|refseq:NP_001305756.1|refseq:NP_001305758.1|refseq:NP_001305760.1|refseq:NP_001305761.1|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043276"(anoikis)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:1901525"(negative regulation of mitophagy)|interpro:IPR000331(Rap/ran-GAP)|interpro:IPR003913(Tuberin)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018515|interpro:IPR024584|interpro:IPR027107|interpro:IPR035974|mint:P49815|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-198323|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674400|reactome:R-HSA-8854214|refseq:XP_005255586.2|refseq:XP_016879105.1	ensembl:ENST00000356063|ensembl:ENSP00000348359|ensembl:ENSP00000354498|ensembl:ENST00000528594|ensembl:ENSP00000435520|ensembl:ENST00000530994|ensembl:ENSP00000431508|ensembl:ENSP00000469820|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR037810|mint:Q86UU1|ensembl:ENSG00000019144(gene)|ensembl:ENST00000361417(transcript)|ensembl:ENST00000600882(transcript)|go:"GO:0010470"(regulation of gastrulation)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0045180"(basal cortex)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:1904261"(positive regulation of basement membrane assembly involved in embryonic body morphogenesis)|interpro:IPR000253(Forkhead-associated)|interpro:IPR001849(Pleckstrin-like)|refseq:NP_001138230.1|refseq:NP_001138231.1|refseq:NP_055972.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:II0K3oybyrXfM4GEYMwV2ZyoWwE9606	rogid:Za4UuXVuMr4gzY2kr8EadOf5hWA9606	rigid:WGU8McdEjFhb62p795Ssk+vhIi0	false	sufficient binding region:1-410	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49815	uniprotkb:Q7Z2W9	intact:EBI-396587|uniprotkb:O75275|uniprotkb:Q8TAZ1|uniprotkb:A7E2E2|uniprotkb:B4DIQ7|uniprotkb:B4DRN2|uniprotkb:Q4LE71|uniprotkb:C9J378|ensembl:ENSP00000219476|uniprotkb:B4DIL8|uniprotkb:B7Z2B8	intact:EBI-6393520|ensembl:ENSP00000354580|uniprotkb:C9JPR2|uniprotkb:A6NKU0	psi-mi:tsc2_human(display_long)|uniprotkb:TSC2(gene name)|psi-mi:TSC2(display_short)|uniprotkb:Tuberous sclerosis 2 protein(gene name synonym)|uniprotkb:TSC4(gene name synonym)	psi-mi:rm21_human(display_long)|uniprotkb:MRPL21(gene name)|psi-mi:MRPL21(display_short)|uniprotkb:Mitochondrial large ribosomal subunit protein bL21m(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26516101|imex:IM-28561-513	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000539.2|refseq:NP_001070651.1|refseq:NP_001107854.1|ensembl:ENSG00000103197(gene)|ensembl:ENST00000219476(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006897"(endocytosis)|go:"GO:0007507"(heart development)|go:"GO:0008104"(protein localization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|refseq:NP_001305756.1|refseq:NP_001305758.1|refseq:NP_001305760.1|refseq:NP_001305761.1|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043276"(anoikis)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:1901525"(negative regulation of mitophagy)|interpro:IPR000331(Rap/ran-GAP)|interpro:IPR003913(Tuberin)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018515|interpro:IPR024584|interpro:IPR027107|interpro:IPR035974|mint:P49815|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-198323|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674400|reactome:R-HSA-8854214|refseq:XP_005255586.2|refseq:XP_016879105.1	ensembl:ENSG00000197345(gene)|ensembl:ENST00000362034(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005762"(mitochondrial large ribosomal subunit)|go:"GO:0006412"(translation)|interpro:IPR001787(Ribosomal protein L21)|interpro:IPR028909|interpro:IPR036164|mint:Q7Z2W9|rcsb pdb:3J7Y|rcsb pdb:3J9M|rcsb pdb:5OOL|rcsb pdb:5OOM|rcsb pdb:6I9R|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5H|rcsb pdb:7A5I|rcsb pdb:7A5J|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7L20|rcsb pdb:7O9K|rcsb pdb:7O9M|rcsb pdb:7ODR|rcsb pdb:7ODS|rcsb pdb:7ODT|rcsb pdb:7OF0|rcsb pdb:7OF2|rcsb pdb:7OF3|rcsb pdb:7OF4|rcsb pdb:7OF5|rcsb pdb:7OF6|rcsb pdb:7OF7|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276|refseq:NP_852615.1|refseq:NP_852616.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:II0K3oybyrXfM4GEYMwV2ZyoWwE9606	rogid:AtmLgjvRKsb8i5m6dl41VwqA1+Q9606	rigid:Ooyt15ZGhI4xk7pAun92nBhQXs8	false	sufficient binding region:1-410	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49815	uniprotkb:Q9UHC7	intact:EBI-396587|uniprotkb:O75275|uniprotkb:Q8TAZ1|uniprotkb:A7E2E2|uniprotkb:B4DIQ7|uniprotkb:B4DRN2|uniprotkb:Q4LE71|uniprotkb:C9J378|ensembl:ENSP00000219476|uniprotkb:B4DIL8|uniprotkb:B7Z2B8	intact:EBI-373524|uniprotkb:Q6GSF1|uniprotkb:Q9H0G0|uniprotkb:Q9UEZ7|uniprotkb:A4D1T7|uniprotkb:B3KXB4|uniprotkb:Q256Y7|uniprotkb:Q59G11|uniprotkb:Q9UHW2|ensembl:ENSP00000255977	psi-mi:tsc2_human(display_long)|uniprotkb:TSC2(gene name)|psi-mi:TSC2(display_short)|uniprotkb:Tuberous sclerosis 2 protein(gene name synonym)|uniprotkb:TSC4(gene name synonym)	psi-mi:mkrn1_human(display_long)|uniprotkb:MKRN1(gene name)|psi-mi:MKRN1(display_short)|uniprotkb:RING finger protein 61(gene name synonym)|uniprotkb:RNF61(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase makorin-1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26516092|imex:IM-28561-95	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000539.2|refseq:NP_001070651.1|refseq:NP_001107854.1|ensembl:ENSG00000103197(gene)|ensembl:ENST00000219476(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006897"(endocytosis)|go:"GO:0007507"(heart development)|go:"GO:0008104"(protein localization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|refseq:NP_001305756.1|refseq:NP_001305758.1|refseq:NP_001305760.1|refseq:NP_001305761.1|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043276"(anoikis)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:1901525"(negative regulation of mitophagy)|interpro:IPR000331(Rap/ran-GAP)|interpro:IPR003913(Tuberin)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018515|interpro:IPR024584|interpro:IPR027107|interpro:IPR035974|mint:P49815|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-198323|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674400|reactome:R-HSA-8854214|refseq:XP_005255586.2|refseq:XP_016879105.1	refseq:XP_011514299.1|refseq:XP_011514300.1|refseq:NP_001138597.1|refseq:NP_038474.2|ensembl:ENSP00000255977|ensembl:ENST00000443720|ensembl:ENSP00000416369|ensembl:ENST00000474576|ensembl:ENSP00000417863|ensembl:ENSG00000133606(gene)|ensembl:ENST00000255977(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000571(Zinc finger, CCCH-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR031644|interpro:IPR036855|interpro:IPR041367|mint:Q9UHC7|reactome:R-HSA-198323|reactome:R-HSA-8948751|reactome:R-HSA-983168	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:II0K3oybyrXfM4GEYMwV2ZyoWwE9606	rogid:oU5t6f0XORO+6RMyVdR3FqDlh0Y9606	rigid:uxAxiTTsDu8wHNrrp2oTzpqOx3U	false	sufficient binding region:1-410	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49815	uniprotkb:P04406	intact:EBI-396587|uniprotkb:O75275|uniprotkb:Q8TAZ1|uniprotkb:A7E2E2|uniprotkb:B4DIQ7|uniprotkb:B4DRN2|uniprotkb:Q4LE71|uniprotkb:C9J378|ensembl:ENSP00000219476|uniprotkb:B4DIL8|uniprotkb:B7Z2B8	intact:EBI-354056|uniprotkb:P00354|uniprotkb:Q53X65|uniprotkb:E7EUT4|ensembl:ENSP00000229239|ensembl:ENSP00000380068|ensembl:ENSP00000380070	psi-mi:tsc2_human(display_long)|uniprotkb:TSC2(gene name)|psi-mi:TSC2(display_short)|uniprotkb:Tuberous sclerosis 2 protein(gene name synonym)|uniprotkb:TSC4(gene name synonym)	psi-mi:g3p_human(display_long)|uniprotkb:GAPDH(gene name)|psi-mi:GAPDH(display_short)|uniprotkb:OK/SW-cl.12(orf name)|uniprotkb:CDABP0047(orf name)|uniprotkb:GAPD(gene name synonym)|uniprotkb:Peptidyl-cysteine S-nitrosylase GAPDH(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26516083|imex:IM-28561-953	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000539.2|refseq:NP_001070651.1|refseq:NP_001107854.1|ensembl:ENSG00000103197(gene)|ensembl:ENST00000219476(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006897"(endocytosis)|go:"GO:0007507"(heart development)|go:"GO:0008104"(protein localization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|refseq:NP_001305756.1|refseq:NP_001305758.1|refseq:NP_001305760.1|refseq:NP_001305761.1|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043276"(anoikis)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:1901525"(negative regulation of mitophagy)|interpro:IPR000331(Rap/ran-GAP)|interpro:IPR003913(Tuberin)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018515|interpro:IPR024584|interpro:IPR027107|interpro:IPR035974|mint:P49815|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-198323|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674400|reactome:R-HSA-8854214|refseq:XP_005255586.2|refseq:XP_016879105.1	refseq:NP_002037.2|refseq:NP_001243728.1|refseq:NP_001276674.1|refseq:NP_001276675.1|dip:DIP-32521N|go:"GO:0031965"(nuclear membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0035605"(peptidyl-cysteine S-nitrosylase activity)|go:"GO:0035606"(peptidyl-cysteine S-trans-nitrosylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050661"(NADP binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0050832"(defense response to fungus)|go:"GO:0051287"(NAD binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051873"(killing by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0097452"(GAIT complex)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR006424(Glyceraldehyde-3-phosphate dehydrogenase, type I)|interpro:IPR020828|interpro:IPR020829|interpro:IPR020830|interpro:IPR020831|interpro:IPR036291|mint:P04406|rcsb pdb:1U8F|rcsb pdb:1ZNQ|rcsb pdb:2FEH|rcsb pdb:3GPD|rcsb pdb:4WNC|rcsb pdb:4WNI|rcsb pdb:6ADE|rcsb pdb:6M61|rcsb pdb:6YND|rcsb pdb:6YNE|rcsb pdb:6YNF|rcsb pdb:6YNH|reactome:R-HSA-70171|reactome:R-HSA-70263|rcsb pdb:6IQ6|ensembl:ENSG00000111640(gene)|ensembl:ENST00000229239(transcript)|ensembl:ENST00000396859(transcript)|ensembl:ENST00000396861(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0004365"("glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0008017"(microtubule binding)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0031640"(killing of cells of another organism)	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:II0K3oybyrXfM4GEYMwV2ZyoWwE9606	rogid:9YENN/dfKl/d0tJtfFyQp2o8eAc9606	rigid:p3I2XTCijTLLRXFEfUoGD5YZDTE	false	sufficient binding region:1-410	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49815	intact:EBI-26516071	intact:EBI-396587|uniprotkb:O75275|uniprotkb:Q8TAZ1|uniprotkb:A7E2E2|uniprotkb:B4DIQ7|uniprotkb:B4DRN2|uniprotkb:Q4LE71|uniprotkb:C9J378|ensembl:ENSP00000219476|uniprotkb:B4DIL8|uniprotkb:B7Z2B8	-	psi-mi:tsc2_human(display_long)|uniprotkb:TSC2(gene name)|psi-mi:TSC2(display_short)|uniprotkb:Tuberous sclerosis 2 protein(gene name synonym)|uniprotkb:TSC4(gene name synonym)	psi-mi:eef1a1(display_short)|psi-mi:EBI-26516071(display_long)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26516074|imex:IM-28561-1157	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000539.2|refseq:NP_001070651.1|refseq:NP_001107854.1|ensembl:ENSG00000103197(gene)|ensembl:ENST00000219476(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006897"(endocytosis)|go:"GO:0007507"(heart development)|go:"GO:0008104"(protein localization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|refseq:NP_001305756.1|refseq:NP_001305758.1|refseq:NP_001305760.1|refseq:NP_001305761.1|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043276"(anoikis)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:1901525"(negative regulation of mitophagy)|interpro:IPR000331(Rap/ran-GAP)|interpro:IPR003913(Tuberin)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018515|interpro:IPR024584|interpro:IPR027107|interpro:IPR035974|mint:P49815|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-198323|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674400|reactome:R-HSA-8854214|refseq:XP_005255586.2|refseq:XP_016879105.1	uniprotkb:EEF1A1(uniprot-removed-ac)	-	-	caution:This sequence has been withdrawn from Uniprot.|no-uniprot-update:|caution:The sequence has been withdrawn from uniprot.	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:II0K3oybyrXfM4GEYMwV2ZyoWwE9606	-	-	false	sufficient binding region:1-410	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49815	uniprotkb:Q8N283	intact:EBI-396587|uniprotkb:O75275|uniprotkb:Q8TAZ1|uniprotkb:A7E2E2|uniprotkb:B4DIQ7|uniprotkb:B4DRN2|uniprotkb:Q4LE71|uniprotkb:C9J378|ensembl:ENSP00000219476|uniprotkb:B4DIL8|uniprotkb:B7Z2B8	intact:EBI-2813523|uniprotkb:B4DL62|uniprotkb:A6NEU0|uniprotkb:Q3MJ10|uniprotkb:Q96LS3|ensembl:ENSP00000347802	psi-mi:tsc2_human(display_long)|uniprotkb:TSC2(gene name)|psi-mi:TSC2(display_short)|uniprotkb:Tuberous sclerosis 2 protein(gene name synonym)|uniprotkb:TSC4(gene name synonym)	psi-mi:anr35_human(display_long)|uniprotkb:ANKRD35(gene name)|psi-mi:ANKRD35(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26516062|imex:IM-28561-511	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000539.2|refseq:NP_001070651.1|refseq:NP_001107854.1|ensembl:ENSG00000103197(gene)|ensembl:ENST00000219476(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006897"(endocytosis)|go:"GO:0007507"(heart development)|go:"GO:0008104"(protein localization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|refseq:NP_001305756.1|refseq:NP_001305758.1|refseq:NP_001305760.1|refseq:NP_001305761.1|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043276"(anoikis)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:1901525"(negative regulation of mitophagy)|interpro:IPR000331(Rap/ran-GAP)|interpro:IPR003913(Tuberin)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018515|interpro:IPR024584|interpro:IPR027107|interpro:IPR035974|mint:P49815|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-198323|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674400|reactome:R-HSA-8854214|refseq:XP_005255586.2|refseq:XP_016879105.1	ensembl:ENSG00000198483(gene)|ensembl:ENST00000355594(transcript)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|mint:Q8N283|refseq:NP_653299.4	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:II0K3oybyrXfM4GEYMwV2ZyoWwE9606	rogid:gKpYjof24pm0XACs5Co0Kuu5gXc9606	rigid:2dXy6mAtbGjLKgO7hpshRS0FNJo	false	sufficient binding region:1-410	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49815	uniprotkb:P35609	intact:EBI-396587|uniprotkb:O75275|uniprotkb:Q8TAZ1|uniprotkb:A7E2E2|uniprotkb:B4DIQ7|uniprotkb:B4DRN2|uniprotkb:Q4LE71|uniprotkb:C9J378|ensembl:ENSP00000219476|uniprotkb:B4DIL8|uniprotkb:B7Z2B8	intact:EBI-77797|uniprotkb:Q86TF4|ensembl:ENSP00000355537|uniprotkb:Q86TI8|uniprotkb:B1ANE4|intact:EBI-928705|uniprotkb:B2RCS5	psi-mi:tsc2_human(display_long)|uniprotkb:TSC2(gene name)|psi-mi:TSC2(display_short)|uniprotkb:Tuberous sclerosis 2 protein(gene name synonym)|uniprotkb:TSC4(gene name synonym)	psi-mi:actn2_human(display_long)|uniprotkb:ACTN2(gene name)|psi-mi:ACTN2(display_short)|uniprotkb:Alpha-actinin skeletal muscle isoform 2(gene name synonym)|uniprotkb:F-actin cross-linking protein(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26516053|imex:IM-28561-93	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000539.2|refseq:NP_001070651.1|refseq:NP_001107854.1|ensembl:ENSG00000103197(gene)|ensembl:ENST00000219476(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006897"(endocytosis)|go:"GO:0007507"(heart development)|go:"GO:0008104"(protein localization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|refseq:NP_001305756.1|refseq:NP_001305758.1|refseq:NP_001305760.1|refseq:NP_001305761.1|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043276"(anoikis)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:1901525"(negative regulation of mitophagy)|interpro:IPR000331(Rap/ran-GAP)|interpro:IPR003913(Tuberin)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018515|interpro:IPR024584|interpro:IPR027107|interpro:IPR035974|mint:P49815|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-198323|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674400|reactome:R-HSA-8854214|refseq:XP_005255586.2|refseq:XP_016879105.1	refseq:NP_001094.1|ensembl:ENSG00000077522(gene)|ensembl:ENST00000366578(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005925"(focal adhesion)|go:"GO:0006936"(muscle contraction)|go:"GO:0007155"(cell adhesion)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030018"(Z disc)|go:"GO:0030035"(microspike assembly)|go:"GO:0030175"(filopodium)|go:"GO:0030274"(LIM domain binding)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031143"(pseudopodium)|go:"GO:0031432"(titin binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043267"(negative regulation of potassium ion transport)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045214"(sarcomere organization)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051015"(actin filament binding)|go:"GO:0051373"(FATZ binding)|go:"GO:0051695"(actin filament uncapping)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070080"(titin Z domain binding)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086097"(phospholipase C-activating angiotensin-activated signaling pathway)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|go:"GO:2001137"(positive regulation of endocytic recycling)|go:"GO:0030374"(nuclear receptor coactivator activity)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR036872|mint:P35609|rcsb pdb:1H8B|rcsb pdb:1HCI|rcsb pdb:1QUU|rcsb pdb:4D1E|rcsb pdb:5A36|rcsb pdb:5A37|rcsb pdb:5A38|rcsb pdb:5A4B|rcsb pdb:6SWT|rcsb pdb:6TS3|rcsb pdb:7A8T|rcsb pdb:7A8U|reactome:R-HSA-114608|go:"GO:2001259"(positive regulation of cation channel activity)|reactome:R-HSA-373753|reactome:R-HSA-390522|reactome:R-HSA-442982|reactome:R-HSA-5673001|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-9620244|reactome:R-HSA-438066|refseq:NP_001265272.1|refseq:NP_001265273.1|dip:DIP-383N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:II0K3oybyrXfM4GEYMwV2ZyoWwE9606	rogid:9jws8DZxpttkzqPfDxEzORNnwcE9606	rigid:sp1csiUkVxJgUQWiWTMLjQYGR3Q	false	sufficient binding region:1-410	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49815	uniprotkb:O43236	intact:EBI-396587|uniprotkb:O75275|uniprotkb:Q8TAZ1|uniprotkb:A7E2E2|uniprotkb:B4DIQ7|uniprotkb:B4DRN2|uniprotkb:Q4LE71|uniprotkb:C9J378|ensembl:ENSP00000219476|uniprotkb:B4DIL8|uniprotkb:B7Z2B8	intact:EBI-1047513|uniprotkb:Q9UM58|uniprotkb:Q6IAP3|uniprotkb:B2RD42|uniprotkb:B3KSX9|uniprotkb:B4DXC6|uniprotkb:B4DXV5|uniprotkb:Q9H315|ensembl:ENSP00000321674|uniprotkb:A0A5F9ZHH3|uniprotkb:Q8N821|uniprotkb:Q8NEP4|intact:EBI-25939820|intact:EBI-13336111	psi-mi:tsc2_human(display_long)|uniprotkb:TSC2(gene name)|psi-mi:TSC2(display_short)|uniprotkb:Tuberous sclerosis 2 protein(gene name synonym)|uniprotkb:TSC4(gene name synonym)	psi-mi:sept4_human(display_long)|uniprotkb:SEPTIN4(gene name)|psi-mi:SEPTIN4(display_short)|uniprotkb:ARTS(gene name synonym)|uniprotkb:Apoptosis-related protein in the TGF-beta signaling pathway(gene name synonym)|uniprotkb:Bradeion beta(gene name synonym)|uniprotkb:Brain protein H5(gene name synonym)|uniprotkb:CE5B3 beta(gene name synonym)|uniprotkb:Cell division control-related protein 2(gene name synonym)|uniprotkb:Cerebral protein 7(gene name synonym)|uniprotkb:PNUTL2(gene name synonym)|uniprotkb:Peanut-like protein 2(gene name synonym)|uniprotkb:SEP4(gene name synonym)|uniprotkb:SEPT4(gene name synonym)|uniprotkb:hucep-7(orf name)|uniprotkb:C17orf47(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26516044|imex:IM-28561-1657	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000539.2|refseq:NP_001070651.1|refseq:NP_001107854.1|ensembl:ENSG00000103197(gene)|ensembl:ENST00000219476(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006897"(endocytosis)|go:"GO:0007507"(heart development)|go:"GO:0008104"(protein localization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|refseq:NP_001305756.1|refseq:NP_001305758.1|refseq:NP_001305760.1|refseq:NP_001305761.1|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043276"(anoikis)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:1901525"(negative regulation of mitophagy)|interpro:IPR000331(Rap/ran-GAP)|interpro:IPR003913(Tuberin)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018515|interpro:IPR024584|interpro:IPR027107|interpro:IPR035974|mint:P49815|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-198323|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674400|reactome:R-HSA-8854214|refseq:XP_005255586.2|refseq:XP_016879105.1	refseq:XP_011523213.1|refseq:XP_011523214.1|refseq:NP_001185642.1|refseq:NP_004565.1|refseq:NP_536341.1|refseq:NP_536340.1|refseq:NP_001033793.2|refseq:NP_001243711.1|refseq:NP_001243751.1|ensembl:ENSG00000108387(gene)|interpro:IPR027417|interpro:IPR030379|mint:O43236|rcsb pdb:6WB3|reactome:R-HSA-111457|reactome:R-HSA-111469|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|ensembl:ENST00000317268(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0005829"(cytosol)|go:"GO:0005940"(septin ring)|go:"GO:0006915"(apoptotic process)|go:"GO:0001764"(neuron migration)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0003924"(GTPase activity)|go:"GO:0030317"(flagellated sperm motility)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0005198"(structural molecule activity)|go:"GO:0031105"(septin complex)|go:"GO:0005525"(GTP binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0032153"(cell division site)|go:"GO:0034613"(cellular protein localization)|go:"GO:0005654"(nucleoplasm)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043204"(perikaryon)|go:"GO:0048515"(spermatid differentiation)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061640"(cytoskeleton-dependent cytokinesis)|go:"GO:0097227"(sperm annulus)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR016491(Septin)|refseq:XP_006722017.1|refseq:XP_006722018.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:II0K3oybyrXfM4GEYMwV2ZyoWwE9606	rogid:bS5LZDK5bxr0WEZsE35enupzNQs9606	rigid:fofHEp1e0OF53qSY9zENq4BAdn8	false	sufficient binding region:1-410	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q92574	uniprotkb:Q2M1K9	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	intact:EBI-950016|intact:EBI-28976649|ensembl:ENSP00000455426|uniprotkb:O94860|uniprotkb:Q9NZ13|uniprotkb:Q76N04	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:zn423_human(display_long)|uniprotkb:OAZ(gene name synonym)|uniprotkb:Olf1/EBF-associated zinc finger protein(gene name synonym)|uniprotkb:Smad- and Olf-interacting zinc finger protein(gene name synonym)|uniprotkb:ZNF423(gene name)|psi-mi:ZNF423(display_short)|uniprotkb:KIAA0760(gene name synonym)|uniprotkb:NPHP14(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26516035|imex:IM-28561-509	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	go:"GO:0021930"(cerebellar granule cell precursor proliferation)|go:"GO:0021938"(smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:Q2M1K9|rcsb pdb:2MDG|ensembl:ENSG00000102935(gene)|ensembl:ENST00000561648(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007219"(Notch signaling pathway)|refseq:NP_055884.2|ensembl:ENSP00000455426|ensembl:ENST00000562520|ensembl:ENSP00000457664|ensembl:ENST00000562871|ensembl:ENSP00000457928|refseq:NP_001258549.1|refseq:XP_005255913.1|refseq:XP_016878567.1|refseq:XP_016878566.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	rogid:MvDTye6jC364XYE9jlFukJM+fAM9606	rigid:eWoVNB/ztPtYgEs72NOvsl6aWK8	false	sufficient binding region:720-1000	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q92574	uniprotkb:P08670	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	intact:EBI-353844|uniprotkb:Q15867|uniprotkb:Q15868|uniprotkb:Q15869|uniprotkb:Q548L2|uniprotkb:Q6LER9|uniprotkb:Q8N850|uniprotkb:Q96ML2|uniprotkb:Q9NTM3|uniprotkb:B0YJC2|intact:EBI-3442369|uniprotkb:D3DRU4|ensembl:ENSP00000224237|ensembl:ENSP00000446007	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:vime_human(display_long)|uniprotkb:VIM(gene name)|psi-mi:VIM(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26516026|imex:IM-28561-1437	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	refseq:NP_003371.2|ensembl:ENSG00000026025(gene)|ensembl:ENST00000224237(transcript)|ensembl:ENST00000544301(transcript)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005212"(structural constituent of eye lens)|go:"GO:0005737"(cytoplasm)|go:"GO:0005777"(peroxisome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014002"(astrocyte development)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031252"(cell leading edge)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0070307"(lens fiber cell development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071225"(cellular response to muramyl dipeptide)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1990254"(keratin filament binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|interpro:IPR027699|interpro:IPR039008|mint:P08670|rcsb pdb:1GK4|rcsb pdb:1GK6|rcsb pdb:1GK7|rcsb pdb:3G1E|rcsb pdb:3KLT|rcsb pdb:3S4R|rcsb pdb:3SSU|rcsb pdb:3SWK|rcsb pdb:3TRT|rcsb pdb:3UF1|rcsb pdb:4MCY|rcsb pdb:4MCZ|rcsb pdb:4MD0|rcsb pdb:4MD5|rcsb pdb:4MDI|rcsb pdb:4MDJ|rcsb pdb:4YPC|rcsb pdb:4YV3|rcsb pdb:5WHF|rcsb pdb:6ATF|rcsb pdb:6ATI|rcsb pdb:6BIR|rcsb pdb:6YXK|reactome:R-HSA-264870|reactome:R-HSA-390522|reactome:R-HSA-6785807|reactome:R-HSA-9013422|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9646399|refseq:XP_006717563.1|dip:DIP-32507N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	rogid:GhAhVuXMNxi6P5J0CfNi5l9bjRk9606	rigid:f0LHbpeUteCM75DjQdHH2v4NrQs	false	sufficient binding region:720-1000	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q92574	uniprotkb:Q9H2D6	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	intact:EBI-715619|uniprotkb:B1AHD4|uniprotkb:B1AHD7|uniprotkb:O94797|uniprotkb:Q2PZW8|uniprotkb:Q2Q3Z9|uniprotkb:Q2Q400|uniprotkb:Q5R3M6|uniprotkb:Q96DW1|uniprotkb:Q9BT77|uniprotkb:Q9BTL7|uniprotkb:Q9BY98|uniprotkb:Q9Y3L4|ensembl:ENSP00000496394|intact:EBI-2560917|uniprotkb:F2Z2W0|uniprotkb:F8W6V6	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:tara_human(display_long)|uniprotkb:Protein Tara(gene name synonym)|uniprotkb:Trio-associated repeat on actin(gene name synonym)|uniprotkb:TRIOBP(gene name)|psi-mi:TRIOBP(display_short)|uniprotkb:KIAA1662(gene name synonym)|uniprotkb:TARA(gene name synonym)|uniprotkb:HRIHFB2122(orf name)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26516017|imex:IM-28561-1655	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	refseq:NP_001034230.1|refseq:NP_008963.3|refseq:NP_619538.2|ensembl:ENSG00000100106(gene)|ensembl:ENST00000644935(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0007049"(cell cycle)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030047"(actin modification)|go:"GO:0030496"(midbody)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0045159"(myosin II binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0051016"(barbed-end actin filament capping)|go:"GO:0051301"(cell division)|go:"GO:0060088"(auditory receptor cell stereocilium organization)|go:"GO:0120044"(stereocilium base)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039597|mint:Q9H2D6|reactome:R-HSA-9662360|reactome:R-HSA-9662361|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	rogid:2evioSQxAnH1x5VPGsZyK+fJTY09606	rigid:nKFuLZdymMkN2CXY/6hYVI0D56s	false	sufficient binding region:720-1000	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q92574	uniprotkb:O75382	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	intact:EBI-2129889|uniprotkb:Q4V9L4|uniprotkb:Q9C038|uniprotkb:Q9C039|uniprotkb:B7Z5E6|uniprotkb:F5H2Q8|ensembl:ENSP00000340797|ensembl:ENSP00000352508|ensembl:ENSP00000433102	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:trim3_human(display_long)|uniprotkb:TRIM3(gene name)|psi-mi:TRIM3(display_short)|uniprotkb:BERP(gene name synonym)|uniprotkb:RNF22(gene name synonym)|uniprotkb:RNF97(gene name synonym)|uniprotkb:RING finger protein 22(gene name synonym)|uniprotkb:Brain-expressed RING finger protein(gene name synonym)|uniprotkb:RING finger protein 97(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26516008|imex:IM-28561-1435	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	refseq:XP_011518146.1|refseq:XP_011518147.1|refseq:NP_006449.2|refseq:NP_150594.2|refseq:XP_016872587.1|refseq:XP_016872588.1|refseq:NP_001234935.1|refseq:NP_001234936.1|ensembl:ENSG00000110171(gene)|ensembl:ENST00000345851(transcript)|ensembl:ENST00000359518(transcript)|ensembl:ENST00000525074(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0007399"(nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015031"(protein transport)|go:"GO:0030425"(dendrite)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001258(NHL repeat)|interpro:IPR001298(Filamin/ABP280 repeat)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003649(B-box, C-terminal)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR013017(NHL repeat, subgroup)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR017907|interpro:IPR027370|mint:O75382|reactome:R-HSA-877300	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	rogid:Vz2XqDSJXAWxxubxtghV91m9K009606	rigid:bZT7m++k4assogPPR6Y+siY+BqU	false	sufficient binding region:720-1000	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q92574	uniprotkb:Q9UBB9	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	intact:EBI-1105213|uniprotkb:O95908|uniprotkb:Q5H8V8|uniprotkb:Q9UGV7|uniprotkb:Q9Y2Q8|ensembl:ENSP00000383892|ensembl:ENSP00000384297|ensembl:ENSP00000384421|ensembl:ENSP00000480171|ensembl:ENSP00000385861|uniprotkb:Q20WL0	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:tfp11_human(display_long)|uniprotkb:TFIP11(gene name)|psi-mi:TFIP11(display_short)|uniprotkb:HSPC006(orf name)|uniprotkb:STIP(gene name synonym)|uniprotkb:Septin and tuftelin-interacting protein 1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515999|imex:IM-28561-1653	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	ensembl:ENSG00000100109(gene)|refseq:NP_001008697.1|refseq:NP_036275.1|go:"GO:0016607"(nuclear speck)|ensembl:ENST00000405938(transcript)|ensembl:ENST00000407148(transcript)|ensembl:ENST00000407431(transcript)|ensembl:ENST00000407690(transcript)|ensembl:ENST00000619735(transcript)|go:"GO:0000390"(spliceosomal complex disassembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006396"(RNA processing)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031848"(protection from non-homologous end joining at telomere)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0071008"(U2-type post-mRNA release spliceosomal complex)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1904876"(negative regulation of DNA ligase activity)|go:"GO:2001033"(negative regulation of double-strand break repair via nonhomologous end joining)|interpro:IPR000467(D111/G-patch)|interpro:IPR022159|interpro:IPR022783|interpro:IPR024933|mint:Q9UBB9|reactome:R-HSA-72163|refseq:XP_011528381.1|refseq:XP_016884224.1|refseq:NP_001333786.1|refseq:NP_001333787.1|refseq:NP_001333788.1|refseq:NP_001333790.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	rogid:Brk0v9dAoy5ntoJVHFsvt+FFE3g9606	rigid:hwEH92yIiRwqxFjbpJxz2VbdaPQ	false	sufficient binding region:400-724	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q92574	uniprotkb:Q92844	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	intact:EBI-356349|uniprotkb:Q92885|uniprotkb:D3DPB5|ensembl:ENSP00000259075|ensembl:ENSP00000376505|uniprotkb:Q7Z4J6	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:tank_human(display_long)|uniprotkb:TANK(gene name)|psi-mi:TANK(display_short)|uniprotkb:ITRAF(gene name synonym)|uniprotkb:TRAF2(gene name synonym)|uniprotkb:TRAF-interacting protein(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515990|imex:IM-28561-737	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	refseq:NP_001186064.1|refseq:NP_004171.2|refseq:NP_597841.1|go:"GO:2000158"(positive regulation of ubiquitin-specific protease activity)|interpro:IPR024581|interpro:IPR039669|interpro:IPR041641|mint:Q92844|rcsb pdb:1KZZ|rcsb pdb:1L0A|rcsb pdb:5H10|reactome:R-HSA-9013973|reactome:R-HSA-933541|reactome:R-HSA-936964|go:"GO:1903003"(positive regulation of protein deubiquitination)|ensembl:ENST00000259075(transcript)|ensembl:ENST00000392749(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035800"(deubiquitinase activator activity)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071479"(cellular response to ionizing radiation)|ensembl:ENSG00000136560(gene)|refseq:XP_016858585.1|refseq:XP_016858586.1|dip:DIP-27516N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	rogid:B6PUVX1PZ5XmFszyF0tRSwfbb4M9606	rigid:t0M318upxSsd92FLpjdVhXbR2I8	false	sufficient binding region:720-1000	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q92574	uniprotkb:Q96R06	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	intact:EBI-413317|uniprotkb:O95213|uniprotkb:Q9BWE8|uniprotkb:Q9NT17|uniprotkb:Q9UFE6|intact:EBI-28972684|ensembl:ENSP00000323300	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:spag5_human(display_long)|uniprotkb:SPAG5(gene name)|psi-mi:SPAG5(display_short)|uniprotkb:Astrin(gene name synonym)|uniprotkb:Mitotic spindle-associated protein p126(gene name synonym)|uniprotkb:Deepest(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515981|imex:IM-28561-951	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	refseq:NP_006452.3|ensembl:ENSP00000323300|ensembl:ENSG00000076382(gene)|ensembl:ENST00000321765(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000776"(kinetochore)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007051"(spindle organization)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008017"(microtubule binding)|go:"GO:0016604"(nuclear body)|go:"GO:0030496"(midbody)|go:"GO:0032388"(positive regulation of intracellular transport)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035253"(ciliary rootlet)|go:"GO:0035371"(microtubule plus-end)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051294"(establishment of spindle orientation)|go:"GO:0051301"(cell division)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090235"(regulation of metaphase plate congression)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:1905832"(positive regulation of spindle assembly)|interpro:IPR028728|mint:Q96R06|dip:DIP-30998N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	rogid:WOMksaINKpqSxqeGIzbmcSRcgdw9606	rigid:U7RVdun+QgdcMPvMRcg+sr7G4+Y	false	sufficient binding region:720-1000	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q92574	uniprotkb:Q92844	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	intact:EBI-356349|uniprotkb:Q92885|uniprotkb:D3DPB5|ensembl:ENSP00000259075|ensembl:ENSP00000376505|uniprotkb:Q7Z4J6	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:tank_human(display_long)|uniprotkb:TANK(gene name)|psi-mi:TANK(display_short)|uniprotkb:ITRAF(gene name synonym)|uniprotkb:TRAF2(gene name synonym)|uniprotkb:TRAF-interacting protein(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515972|imex:IM-28561-299	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	refseq:NP_001186064.1|refseq:NP_004171.2|refseq:NP_597841.1|go:"GO:2000158"(positive regulation of ubiquitin-specific protease activity)|interpro:IPR024581|interpro:IPR039669|interpro:IPR041641|mint:Q92844|rcsb pdb:1KZZ|rcsb pdb:1L0A|rcsb pdb:5H10|reactome:R-HSA-9013973|reactome:R-HSA-933541|reactome:R-HSA-936964|go:"GO:1903003"(positive regulation of protein deubiquitination)|ensembl:ENST00000259075(transcript)|ensembl:ENST00000392749(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035800"(deubiquitinase activator activity)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071479"(cellular response to ionizing radiation)|ensembl:ENSG00000136560(gene)|refseq:XP_016858585.1|refseq:XP_016858586.1|dip:DIP-27516N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	rogid:B6PUVX1PZ5XmFszyF0tRSwfbb4M9606	rigid:t0M318upxSsd92FLpjdVhXbR2I8	false	sufficient binding region:720-1000	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q92574	uniprotkb:Q9Y566	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	intact:EBI-3442234|uniprotkb:B7WNY6|uniprotkb:Q9NYW9|uniprotkb:A8MXP5|ensembl:ENSP00000293441	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:shan1_human(display_long)|uniprotkb:SHANK1(gene name)|psi-mi:SHANK1(display_short)|uniprotkb:Somatostatin receptor-interacting protein(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515963|imex:IM-28561-1433	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	refseq:XP_011525316.1|refseq:XP_006723296.1|refseq:NP_057232.2|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007616"(long-term memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008306"(associative learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030160"(synaptic receptor adaptor activity)|ensembl:ENSG00000161681(gene)|go:"GO:0030425"(dendrite)|go:"GO:0030534"(adult behavior)|ensembl:ENST00000293441(transcript)|go:"GO:0031877"(somatostatin receptor binding)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042048"(olfactory behavior)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046959"(habituation)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0050894"(determination of affect)|go:"GO:0060013"(righting reflex)|go:"GO:0060074"(synapse maturation)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071532"(ankyrin repeat binding)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036034|interpro:IPR036770|interpro:IPR041489|mint:Q9Y566|rcsb pdb:6CPI|rcsb pdb:6YWZ|rcsb pdb:6YX0|rcsb pdb:6YX1|rcsb pdb:6YX2|reactome:R-HSA-6794361|ensembl:ENSP00000293441|ensembl:ENST00000359082|ensembl:ENSP00000351984|dip:DIP-40834N	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	rogid:XhX+mw+sujJRnA6RoKA1QeVywBY9606	rigid:3CyO8o5AwCr4Y0FV5y0KDLHg6a8	false	sufficient binding region:720-1000	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q92574	uniprotkb:Q9UHV2	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	intact:EBI-748601|uniprotkb:Q9BUE7|ensembl:ENSP00000350633	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:srtd1_human(display_long)|uniprotkb:Transcriptional regulator interacting with the PHD-bromodomain 1(gene name synonym)|uniprotkb:CDK4-binding protein p34SEI1(gene name synonym)|uniprotkb:SERTAD1(gene name)|psi-mi:SERTAD1(display_short)|uniprotkb:SEI1(gene name synonym)|uniprotkb:TRIPBR1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515954|imex:IM-28561-1431	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	refseq:NP_037508.2|ensembl:ENSG00000197019(gene)|ensembl:ENST00000357949(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048096"|interpro:IPR009263(SERTA)|mint:Q9UHV2	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	rogid:40dvjniwxY/UQiyoVREicctpWe09606	rigid:ytLJWFgzdl5RaI+69kL6WlIvhfo	false	sufficient binding region:720-1000	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q92574	uniprotkb:P63302	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	intact:EBI-26508171|ensembl:ENSP00000470941|ensembl:ENSP00000471149|ensembl:ENSP00000473185|uniprotkb:A8MRR7|uniprotkb:O15532|uniprotkb:O19096|uniprotkb:Q86TI9|uniprotkb:Q96KM5	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:selw_human(display_long)|uniprotkb:SELENOW(gene name)|psi-mi:SELENOW(display_short)|uniprotkb:SELW(gene name synonym)|uniprotkb:SEPW1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515945|imex:IM-28561-91	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	ensembl:ENSG00000178980(gene)|ensembl:ENST00000593892(transcript)|ensembl:ENST00000595615(transcript)|ensembl:ENST00000601048(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0010269"(response to selenium ion)|go:"GO:0016209"(antioxidant activity)|interpro:IPR011893(SelT/selW/selH selenoprotein)|interpro:IPR036249|refseq:NP_003000.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	rogid:pqQ7h+0WVj4YveTA3w6HjWVAtCA9606	rigid:NIqpXp1Yexz8L2I59R1rPcuio/I	false	sufficient binding region:720-1000	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q92574	uniprotkb:O94979	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	intact:EBI-1767898|uniprotkb:Q17RR5|uniprotkb:Q5H9P6|uniprotkb:Q5XG74|uniprotkb:Q659G7|uniprotkb:Q6ZU90|uniprotkb:Q7LCX9|uniprotkb:Q86TJ0|uniprotkb:Q8IZH4|uniprotkb:Q9P048|uniprotkb:Q9P0A6|uniprotkb:Q9UM05|uniprotkb:Q9UM06|uniprotkb:B7ZKZ7|uniprotkb:B7ZL00|uniprotkb:B4DIW6|uniprotkb:H7C2W3|ensembl:ENSP00000347329|ensembl:ENSP00000378721|ensembl:ENSP00000400926	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:sc31a_human(display_long)|uniprotkb:SEC31A(gene name)|psi-mi:SEC31A(display_short)|uniprotkb:KIAA0905(gene name synonym)|uniprotkb:SEC31L1(gene name synonym)|uniprotkb:HSPC275(orf name)|uniprotkb:HSPC334(orf name)|uniprotkb:SEC31-related protein A(gene name synonym)|uniprotkb:SEC31-like protein 1(gene name synonym)|uniprotkb:ABP125(gene name synonym)|uniprotkb:ABP130(gene name synonym)|uniprotkb:Web1-like protein(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515936|imex:IM-28561-297	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	refseq:NP_001070674.1|refseq:NP_001070675.1|refseq:NP_001070676.1|refseq:NP_057295.2|refseq:NP_001305048.1|refseq:NP_001305049.1|refseq:NP_001287673.1|refseq:NP_001287674.1|refseq:NP_001177978.1|dip:DIP-40438N|ensembl:ENSG00000138674(gene)|ensembl:ENST00000355196(transcript)|ensembl:ENST00000395310(transcript)|ensembl:ENST00000448323(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0030120"(vesicle coat)|go:"GO:0030127"(COPII vesicle coat)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051592"(response to calcium ion)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0090110"(COPII-coated vesicle cargo loading)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR024298|interpro:IPR036322|interpro:IPR040251|mint:O94979|rcsb pdb:3WXA|reactome:R-HSA-204005|reactome:R-HSA-2132295|reactome:R-HSA-381038|reactome:R-HSA-983170	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	rogid:MvtQi/4RmQ0siNtNoYH6k1rPv1Y9606	rigid:09PElryXGy4zjL0hxFMcrFy7HiE	false	sufficient binding region:400-724	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q92574	uniprotkb:Q96GD3	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	intact:EBI-713793|uniprotkb:Q5VT76|uniprotkb:Q6IAJ4|uniprotkb:Q8WU48|uniprotkb:Q9UKM5|uniprotkb:Q9UKM6|ensembl:ENSP00000318094|ensembl:ENSP00000380359|uniprotkb:B4DRQ8	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:scmh1_human(display_long)|uniprotkb:Sex comb on midleg homolog 1(gene name synonym)|uniprotkb:SCMH1(gene name)|psi-mi:SCMH1(display_short)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515927|imex:IM-28561-949	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	refseq:XP_006710527.1|ensembl:ENSG00000010803(gene)|ensembl:ENST00000326197(transcript)|ensembl:ENST00000397174(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0007283"(spermatogenesis)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010369"(chromocenter)|go:"GO:0016458"(obsolete gene silencing)|go:"GO:0042393"(histone binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR004092(Mbt repeat)|interpro:IPR013761(Sterile alpha motif-type)|go:"GO:0005634"(nucleus)|interpro:IPR021987|interpro:IPR033763|interpro:IPR038348|mint:Q96GD3|rcsb pdb:2P0K|reactome:R-HSA-2559580|reactome:R-HSA-3108214|reactome:R-HSA-3899300|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4655427|reactome:R-HSA-8939243|reactome:R-HSA-8943724|refseq:NP_001026864.1|refseq:NP_001165689.1|refseq:NP_001165690.1|refseq:NP_001165691.1|refseq:NP_001165692.1|refseq:NP_001165693.1|refseq:NP_036368.1|refseq:XP_016856188.1|refseq:XP_016856196.1|refseq:XP_011539335.1|refseq:XP_011539338.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	rogid:e39O++wYwPAUlKUeNfRurqnXbz09606	rigid:XtMWvmiGISuwSt5LUzS5/bwN1vo	false	sufficient binding region:720-1000	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q92574	uniprotkb:Q59EK9	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	intact:EBI-747225|uniprotkb:B2R974|uniprotkb:O15483|uniprotkb:Q7Z3S2|uniprotkb:Q9UF50|intact:EBI-949746|uniprotkb:O60651|ensembl:ENSP00000410862	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:run3a_human(display_long)|uniprotkb:RUNDC3A(gene name)|psi-mi:RUNDC3A(display_short)|uniprotkb:RAP2IP(gene name synonym)|uniprotkb:RPIP8(gene name synonym)|uniprotkb:Rap2-interacting protein 8(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515918|imex:IM-28561-1155	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	refseq:NP_001138297.1|refseq:NP_001138298.1|refseq:NP_006686.1|ensembl:ENSG00000108309(gene)|ensembl:ENST00000426726(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0010753"(positive regulation of cGMP-mediated signaling)|go:"GO:0030695"(GTPase regulator activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR004012(RUN)|interpro:IPR037213|mint:Q59EK9|go:"GO:0007264"(small GTPase mediated signal transduction)	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	rogid:Xib1v1Fk/1XzTAtGXmxvhP+LQqE9606	rigid:fAo4EjMe6E4qb2fQP5lrG+hNV7E	false	sufficient binding region:720-1000	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q92574	uniprotkb:Q86SE5	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	intact:EBI-741520|uniprotkb:Q6ZW87|uniprotkb:Q8N1C2|uniprotkb:B3KTH2|ensembl:ENSP00000428667|ensembl:ENSP00000430367|ensembl:ENSP00000430394|uniprotkb:G3V129	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:ralyl_human(display_long)|uniprotkb:Heterogeneous nuclear ribonucleoprotein C-like 3(gene name synonym)|uniprotkb:RALYL(gene name)|psi-mi:RALYL(display_short)|uniprotkb:HNRPCL3(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515909|imex:IM-28561-295	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	refseq:NP_001093861.1|refseq:NP_001093862.1|refseq:NP_001093863.1|refseq:NP_776247.3|ensembl:ENSG00000184672(gene)|ensembl:ENST00000521268(transcript)|ensembl:ENST00000521695(transcript)|ensembl:ENST00000522455(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0042802"(identical protein binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR017347(Heterogeneous nuclear ribonucleoprotein C, Raly)|interpro:IPR034504|interpro:IPR035979|mint:Q86SE5|refseq:NP_001274173.1|refseq:XP_016868548.1|refseq:XP_016868549.1|refseq:XP_016868550.1|refseq:XP_016868551.1|refseq:XP_016868552.1|refseq:XP_016868553.1|refseq:XP_016868554.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	rogid:/dJc0rSACk93SMMAkFSfi2YdWuo9606	rigid:4Hqtcb3ijdK8LO/1QERAi3f9jTA	false	sufficient binding region:720-1000	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q92574	uniprotkb:O75334	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	intact:EBI-1105129|ensembl:ENSP00000450337|uniprotkb:B3KXA0|uniprotkb:B7ZKZ5|uniprotkb:F8VP68|uniprotkb:Q2M3G8|uniprotkb:B3KVT5|uniprotkb:B7Z2A6|uniprotkb:B7Z3U9|uniprotkb:B7Z663|uniprotkb:E7ERB8|uniprotkb:E7ETG6	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:lipa2_human(display_long)|uniprotkb:PPFIA2(gene name)|psi-mi:PPFIA2(display_short)|uniprotkb:Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-2(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26515900|imex:IM-28561-507	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1	refseq:NP_003616.2|ensembl:ENSG00000139220(gene)|ensembl:ENST00000549396(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0009986"(cell surface)|go:"GO:0030424"(axon)|go:"GO:0043197"(dendritic spine)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050808"(synapse organization)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099181"(structural constituent of presynapse)|go:"GO:0099519"(dense core granule cytoskeletal transport)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR029515|interpro:IPR030441|interpro:IPR037620|interpro:IPR037621|interpro:IPR037622|mint:O75334|rcsb pdb:3TAC|rcsb pdb:3TAD|rcsb pdb:6IUH|rcsb pdb:7D2E|rcsb pdb:7D2G|rcsb pdb:7D2H|reactome:R-HSA-181429|reactome:R-HSA-181430|reactome:R-HSA-210500|reactome:R-HSA-212676|reactome:R-HSA-264642|reactome:R-HSA-388844|refseq:NP_001207403.1|refseq:NP_001207404.1|refseq:NP_001207405.1|refseq:NP_001207406.1|refseq:NP_001207407.1|refseq:NP_001207408.1|refseq:NP_001207409.1|refseq:XP_016875569.1|refseq:XP_016875571.1	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	rogid:JWcUe5GLHo/JyakmiC91TuspElU9606	rigid:defzfLC5iTrYJXpRkqHkFRgqOdY	false	sufficient binding region:720-1000	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q05086	uniprotkb:P55036	intact:EBI-954357|ensembl:ENSP00000497594|uniprotkb:P78355|uniprotkb:Q93066|uniprotkb:Q9UEP4|uniprotkb:Q9UEP5|uniprotkb:Q9UEP6|uniprotkb:Q9UEP7|uniprotkb:Q9UEP8|uniprotkb:Q9UEP9|uniprotkb:A8K8Z9	intact:EBI-359318|uniprotkb:Q5VWC5|uniprotkb:Q9NS92|uniprotkb:D3DV16|ensembl:ENSP00000357879	psi-mi:ube3a_human(display_long)|uniprotkb:E6AP ubiquitin-protein ligase(gene name synonym)|uniprotkb:Oncogenic protein-associated protein E6-AP(gene name synonym)|uniprotkb:Human papillomavirus E6-associated protein(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-54(gene name synonym)|uniprotkb:UBE3A(gene name)|psi-mi:UBE3A(display_short)|uniprotkb:E6AP(gene name synonym)|uniprotkb:EPVE6AP(gene name synonym)|uniprotkb:HPVE6A(gene name synonym)|uniprotkb:HECT-type ubiquitin transferase E3A(gene name synonym)	psi-mi:psmd4_human(display_long)|uniprotkb:PSMD4(gene name)|psi-mi:PSMD4(display_short)|uniprotkb:MCB1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S5A(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN10(gene name synonym)|uniprotkb:Multiubiquitin chain-binding protein(gene name synonym)|uniprotkb:Antisecretory factor 1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Sakai et al. (2011)	doi:10.1126/scitranslmed.3002166|pubmed:21653829|imex:IM-28561	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26516214|imex:IM-28561-97	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0060736"(prostate gland growth)|go:"GO:0061002"(negative regulation of dendritic spine morphogenesis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061743"(motor learning)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:1905528"(positive regulation of Golgi lumen acidification)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:2000058"(regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000569(HECT)|interpro:IPR017134(Ubiquitin-protein ligase E6-AP)|interpro:IPR032353|interpro:IPR035983|interpro:IPR042556|mint:Q05086|rcsb pdb:1C4Z|rcsb pdb:1D5F|rcsb pdb:1EQX|rcsb pdb:2KR1|rcsb pdb:4GIZ|rcsb pdb:4XR8|rcsb pdb:6SJV|rcsb pdb:6SLM|rcsb pdb:6TGK|rcsb pdb:6U19|reactome:R-HSA-983168|ensembl:ENSG00000114062(gene)|ensembl:ENST00000650110(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007420"(brain development)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032570"(response to progesterone)|go:"GO:0035037"(sperm entry)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0042220"(response to cocaine)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048511"(rhythmic process)|refseq:NP_000453.2|refseq:NP_570853.1|refseq:NP_570854.1|refseq:XP_016878033.1|refseq:XP_016878034.1|refseq:XP_011520296.1|refseq:XP_011520297.1|refseq:XP_016878035.1|refseq:XP_016878036.1|refseq:XP_016878037.1|refseq:XP_016878038.1|refseq:XP_016878039.1|dip:DIP-6002N|refseq:XP_005268324.1|refseq:XP_005268325.1|refseq:XP_005268326.1|refseq:XP_005268327.1|refseq:XP_005268328.1|refseq:XP_006720738.1|refseq:XP_006720739.1|refseq:XP_016878040.1|refseq:XP_016878041.1|refseq:XP_016878042.1|refseq:XP_016878043.1|refseq:XP_016878044.1	refseq:NP_002801.1|dip:DIP-38189N|ensembl:ENSG00000159352(gene)|ensembl:ENST00000368884(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043248"(proteasome assembly)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR036465|mint:P55036|rcsb pdb:1P9C|rcsb pdb:1P9D|rcsb pdb:1UEL|rcsb pdb:1YX4|rcsb pdb:1YX5|rcsb pdb:1YX6|rcsb pdb:2KDE|rcsb pdb:2KDF|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6MUN|rcsb pdb:6U19|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168	-	-	-	figure legend:ST2|comment:"Library for Y2H screening used: human brain"|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/10/05	2020/12/11	rogid:w9T67+NDlHSd1tR+FgcX3LI1zpQ9606	rogid:FTJG3ns3Ag/Y3xP3yEydGxppRcA9606	rigid:eGiR5eVVOXh4zzkLYpwcQ7YRtow	false	sufficient binding region:1-159	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)