#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9UKP4 uniprotkb:Q92743 intact:EBI-9028319|uniprotkb:Q14F51|uniprotkb:Q6P7J9|ensembl:ENSP00000373472 intact:EBI-352256|uniprotkb:Q9UNS5|uniprotkb:D3DRE4|ensembl:ENSP00000357980 psi-mi:ats7_human(display_long)|uniprotkb:ADAMTS7(gene name)|psi-mi:ADAMTS7(display_short)|uniprotkb:COMPase(gene name synonym) psi-mi:htra1_human(display_long)|uniprotkb:HTRA1(gene name)|psi-mi:HTRA1(display_short)|uniprotkb:HTRA(gene name synonym)|uniprotkb:PRSS11(gene name synonym)|uniprotkb:High-temperature requirement A serine peptidase 1(gene name synonym)|uniprotkb:L56(gene name synonym)|uniprotkb:Serine protease 11(gene name synonym) psi-mi:"MI:0018"(two hybrid) Campioni et al. (2011) imex:IM-27784|pubmed:21622153 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-25468701|imex:IM-27784-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055087.2|ensembl:ENSG00000136378(gene)|ensembl:ENST00000388820(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071773"(cellular response to BMP stimulus)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR010294(ADAM-TS Spacer 1)|interpro:IPR010909(PLAC)|interpro:IPR013273(Peptidase M12B, ADAM-TS)|interpro:IPR024079|interpro:IPR036383|interpro:IPR041645|reactome:R-HSA-5083635|reactome:R-HSA-5173214 refseq:NP_002766.1|ensembl:ENSG00000166033(gene)|ensembl:ENST00000368984(transcript)|go:"GO:0001890"(placenta development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050687"(negative regulation of defense response to virus)|go:"GO:0060718"(chorionic trophoblast cell differentiation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097187"(dentinogenesis)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058|interpro:IPR041489|rcsb pdb:2JOA|rcsb pdb:2YTW|rcsb pdb:3NUM|rcsb pdb:3NWU|rcsb pdb:3NZI|rcsb pdb:3TJN|rcsb pdb:3TJO|rcsb pdb:3TJQ|rcsb pdb:6Z0E|rcsb pdb:6Z0X|rcsb pdb:6Z0Y|reactome:R-HSA-1474228|dip:DIP-33195N - - - figure legend:Table 1, number 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/05 2020/03/12 rogid:3KuKb7vTBuorVryXEfheolRq38s9606 rogid:Y7lT7nyI9N/3imHOz8Ng+Zagf509606 rigid:ryyZXfooMB85RNP5mTZCJxGf78w false - mutation:328-328 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9UQB3 uniprotkb:Q92743 intact:EBI-7266482|uniprotkb:O43840|uniprotkb:Q9UPM3|uniprotkb:Q9UM66|uniprotkb:O00379|uniprotkb:Q13589|uniprotkb:B0FTZ7|uniprotkb:O15390|uniprotkb:O43206|intact:MINT-223241|ensembl:ENSP00000307134 intact:EBI-352256|uniprotkb:Q9UNS5|uniprotkb:D3DRE4|ensembl:ENSP00000357980 psi-mi:ctnd2_human(display_long)|uniprotkb:CTNND2(gene name)|psi-mi:CTNND2(display_short)|uniprotkb:NPRAP(gene name synonym)|uniprotkb:Delta-catenin(gene name synonym)|uniprotkb:Neural plakophilin-related ARM-repeat protein(gene name synonym)|uniprotkb:Neurojungin(gene name synonym)|uniprotkb:GT24(gene name synonym) psi-mi:htra1_human(display_long)|uniprotkb:HTRA1(gene name)|psi-mi:HTRA1(display_short)|uniprotkb:HTRA(gene name synonym)|uniprotkb:PRSS11(gene name synonym)|uniprotkb:High-temperature requirement A serine peptidase 1(gene name synonym)|uniprotkb:L56(gene name synonym)|uniprotkb:Serine protease 11(gene name synonym) psi-mi:"MI:0018"(two hybrid) Campioni et al. (2011) imex:IM-27784|pubmed:21622153 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-25468707|imex:IM-27784-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001275644.1|refseq:NP_001275645.1|refseq:NP_001275646.1|refseq:NP_001323.1|ensembl:ENSG00000169862(gene)|ensembl:ENST00000304623(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007165"(signal transduction)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030425"(dendrite)|go:"GO:0043204"(perikaryon)|go:"GO:0045296"(cadherin binding)|go:"GO:0050808"(synapse organization)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR028435|go:"GO:0007155"(cell adhesion)|dip:DIP-1138N refseq:NP_002766.1|ensembl:ENSG00000166033(gene)|ensembl:ENST00000368984(transcript)|go:"GO:0001890"(placenta development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050687"(negative regulation of defense response to virus)|go:"GO:0060718"(chorionic trophoblast cell differentiation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097187"(dentinogenesis)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058|interpro:IPR041489|rcsb pdb:2JOA|rcsb pdb:2YTW|rcsb pdb:3NUM|rcsb pdb:3NWU|rcsb pdb:3NZI|rcsb pdb:3TJN|rcsb pdb:3TJO|rcsb pdb:3TJQ|rcsb pdb:6Z0E|rcsb pdb:6Z0X|rcsb pdb:6Z0Y|reactome:R-HSA-1474228|dip:DIP-33195N - comment:mint|comment:homomint|function:"Functions as a transcriptional activator when bound to ZBTB33 (By similarity). May be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating adhesion molecules" - figure legend:Table 1, number 2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/05 2020/03/12 rogid:X2vU6AnVAlHlSUf4TQ7V0FzPo/I9606 rogid:Y7lT7nyI9N/3imHOz8Ng+Zagf509606 rigid:ads+rm6WNnSSuDRJ1nm+sklcTVY false - mutation:328-328 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q13885 uniprotkb:Q92743 intact:EBI-711595|ensembl:ENSP00000369703|uniprotkb:Q6FGZ8|uniprotkb:Q8IWR2 intact:EBI-352256|uniprotkb:Q9UNS5|uniprotkb:D3DRE4|ensembl:ENSP00000357980 psi-mi:tbb2a_human(display_long)|uniprotkb:TUBB2A(gene name)|psi-mi:TUBB2A(display_short)|uniprotkb:TUBB2(gene name synonym)|uniprotkb:Tubulin beta class IIa(gene name synonym) psi-mi:htra1_human(display_long)|uniprotkb:HTRA1(gene name)|psi-mi:HTRA1(display_short)|uniprotkb:HTRA(gene name synonym)|uniprotkb:PRSS11(gene name synonym)|uniprotkb:High-temperature requirement A serine peptidase 1(gene name synonym)|uniprotkb:L56(gene name synonym)|uniprotkb:Serine protease 11(gene name synonym) psi-mi:"MI:0018"(two hybrid) Campioni et al. (2011) imex:IM-27784|pubmed:21622153 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-25468713|imex:IM-27784-21 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) reactome:R-HSA-389960|reactome:R-HSA-389977|reactome:R-HSA-437239|reactome:R-HSA-5610787|reactome:R-HSA-5617833|reactome:R-HSA-5620924|reactome:R-HSA-5626467|reactome:R-HSA-5663220|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8852276|reactome:R-HSA-8955332|reactome:R-HSA-9609690|reactome:R-HSA-9609736|reactome:R-HSA-9619483|reactome:R-HSA-9646399|reactome:R-HSA-9648025|reactome:R-HSA-389957|reactome:R-HSA-983189|reactome:R-HSA-9668328|ensembl:ENSG00000137267(gene)|ensembl:ENST00000333628(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0001764"(neuron migration)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903561"(extracellular vesicle)|interpro:IPR000217(Tubulin)|interpro:IPR002453(Beta tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR013838(Beta tubulin, autoregulation binding site)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:Q13885|reactome:R-HSA-1445148|reactome:R-HSA-190840|reactome:R-HSA-190861|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3371497|reactome:R-HSA-380320|refseq:NP_001060.1|refseq:NP_001297244.1 refseq:NP_002766.1|ensembl:ENSG00000166033(gene)|ensembl:ENST00000368984(transcript)|go:"GO:0001890"(placenta development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050687"(negative regulation of defense response to virus)|go:"GO:0060718"(chorionic trophoblast cell differentiation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097187"(dentinogenesis)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058|interpro:IPR041489|rcsb pdb:2JOA|rcsb pdb:2YTW|rcsb pdb:3NUM|rcsb pdb:3NWU|rcsb pdb:3NZI|rcsb pdb:3TJN|rcsb pdb:3TJO|rcsb pdb:3TJQ|rcsb pdb:6Z0E|rcsb pdb:6Z0X|rcsb pdb:6Z0Y|reactome:R-HSA-1474228|dip:DIP-33195N - - - figure legend:Table 1, number 3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/05 2020/03/12 rogid:XN9uTGU0KxQjMod0AGnM+XJoHyk9606 rogid:Y7lT7nyI9N/3imHOz8Ng+Zagf509606 rigid:Ajlk4NBhxamHpqMyB4lC90bU9yI false - mutation:328-328 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P02452 uniprotkb:Q92743 intact:EBI-982999|uniprotkb:O76045|uniprotkb:P78441|uniprotkb:Q13896|uniprotkb:Q13902|uniprotkb:Q13903|uniprotkb:Q14037|uniprotkb:Q14992|uniprotkb:Q15176|uniprotkb:Q15201|uniprotkb:Q16050|uniprotkb:Q59F64|uniprotkb:Q7KZ30|uniprotkb:Q7KZ34|uniprotkb:Q8IVI5|ensembl:ENSP00000225964|uniprotkb:Q8N473|uniprotkb:Q9UML6|uniprotkb:Q9UMM7 intact:EBI-352256|uniprotkb:Q9UNS5|uniprotkb:D3DRE4|ensembl:ENSP00000357980 psi-mi:co1a1_human(display_long)|uniprotkb:Alpha-1 type I collagen(gene name synonym)|uniprotkb:COL1A1(gene name)|psi-mi:COL1A1(display_short) psi-mi:htra1_human(display_long)|uniprotkb:HTRA1(gene name)|psi-mi:HTRA1(display_short)|uniprotkb:HTRA(gene name synonym)|uniprotkb:PRSS11(gene name synonym)|uniprotkb:High-temperature requirement A serine peptidase 1(gene name synonym)|uniprotkb:L56(gene name synonym)|uniprotkb:Serine protease 11(gene name synonym) psi-mi:"MI:0018"(two hybrid) Campioni et al. (2011) imex:IM-27784|pubmed:21622153 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-25468719|imex:IM-27784-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000079.2|ensembl:ENSG00000108821(gene)|ensembl:ENST00000225964(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001503"(ossification)|go:"GO:0001568"(blood vessel development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001957"(intramembranous ossification)|go:"GO:0001958"(endochondral ossification)|go:"GO:0002020"(protease binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005584"(collagen type I trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0007601"(visual perception)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0015031"(protein transport)|go:"GO:0030020"(extracellular matrix structural constituent conferring tensile strength)|go:"GO:0030141"(secretory granule)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032355"(response to estradiol)|go:"GO:0032964"(collagen biosynthetic process)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0034505"(tooth mineralization)|go:"GO:0038063"(collagen-activated tyrosine kinase receptor signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043588"(skin development)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0044691"(tooth eruption)|go:"GO:0046872"(metal ion binding)|go:"GO:0048407"(platelet-derived growth factor binding)|go:"GO:0048706"(embryonic skeletal system development)|go:"GO:0051591"(response to cAMP)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060325"(face morphogenesis)|go:"GO:0060346"(bone trabecula formation)|go:"GO:0060351"(cartilage development involved in endochondral bone morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071306"(cellular response to vitamin E)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1902618"(cellular response to fluoride)|interpro:IPR000885(Fibrillar collagen, C-terminal)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR008160(Collagen triple helix repeat)|mint:P02452|rcsb pdb:1Q7D|rcsb pdb:2LLP|rcsb pdb:3EJH|rcsb pdb:3GXE|rcsb pdb:5CTD|rcsb pdb:5CTI|rcsb pdb:5CVA|rcsb pdb:5CVB|rcsb pdb:5K31|rcsb pdb:5OU8|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|rcsb pdb:5OU9|rcsb pdb:7E7B|rcsb pdb:7E7D|reactome:R-HSA-114604|reactome:R-HSA-1442490|reactome:R-HSA-1474244|reactome:R-HSA-1650814|reactome:R-HSA-198933|reactome:R-HSA-2022090|reactome:R-HSA-202733|reactome:R-HSA-216083|reactome:R-HSA-2214320|reactome:R-HSA-2243919|reactome:R-HSA-3000170|reactome:R-HSA-3000171|reactome:R-HSA-3000178|reactome:R-HSA-3000480|reactome:R-HSA-430116|reactome:R-HSA-75892|reactome:R-HSA-76009|reactome:R-HSA-8874081|reactome:R-HSA-8940973|reactome:R-HSA-8948216|dip:DIP-36077N refseq:NP_002766.1|ensembl:ENSG00000166033(gene)|ensembl:ENST00000368984(transcript)|go:"GO:0001890"(placenta development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050687"(negative regulation of defense response to virus)|go:"GO:0060718"(chorionic trophoblast cell differentiation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097187"(dentinogenesis)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058|interpro:IPR041489|rcsb pdb:2JOA|rcsb pdb:2YTW|rcsb pdb:3NUM|rcsb pdb:3NWU|rcsb pdb:3NZI|rcsb pdb:3TJN|rcsb pdb:3TJO|rcsb pdb:3TJQ|rcsb pdb:6Z0E|rcsb pdb:6Z0X|rcsb pdb:6Z0Y|reactome:R-HSA-1474228|dip:DIP-33195N - - - figure legend:Table 1, number 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/05 2020/03/12 rogid:x83+B64Cl9zkAVeZ9RCo0BukkwU9606 rogid:Y7lT7nyI9N/3imHOz8Ng+Zagf509606 rigid:tPZrbS7dwcUWjARl+4HTG3J1hPw false - mutation:328-328 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P23142-2 uniprotkb:Q92743 intact:EBI-21529217|ensembl:ENSP00000342212 intact:EBI-352256|uniprotkb:Q9UNS5|uniprotkb:D3DRE4|ensembl:ENSP00000357980 psi-mi:p23142-2(display_long)|uniprotkb:FBLN1(gene name)|psi-mi:FBLN1(display_short)|uniprotkb:PP213(orf name) psi-mi:htra1_human(display_long)|uniprotkb:HTRA1(gene name)|psi-mi:HTRA1(display_short)|uniprotkb:HTRA(gene name synonym)|uniprotkb:PRSS11(gene name synonym)|uniprotkb:High-temperature requirement A serine peptidase 1(gene name synonym)|uniprotkb:L56(gene name synonym)|uniprotkb:Serine protease 11(gene name synonym) psi-mi:"MI:0018"(two hybrid) Campioni et al. (2011) imex:IM-27784|pubmed:21622153 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-25468725|imex:IM-27784-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000077942(gene)|ensembl:ENST00000340923(transcript)|uniprotkb:P23142-2(isoform-parent)|intact:EBI-726652(isoform-parent) refseq:NP_002766.1|ensembl:ENSG00000166033(gene)|ensembl:ENST00000368984(transcript)|go:"GO:0001890"(placenta development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050687"(negative regulation of defense response to virus)|go:"GO:0060718"(chorionic trophoblast cell differentiation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097187"(dentinogenesis)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058|interpro:IPR041489|rcsb pdb:2JOA|rcsb pdb:2YTW|rcsb pdb:3NUM|rcsb pdb:3NWU|rcsb pdb:3NZI|rcsb pdb:3TJN|rcsb pdb:3TJO|rcsb pdb:3TJQ|rcsb pdb:6Z0E|rcsb pdb:6Z0X|rcsb pdb:6Z0Y|reactome:R-HSA-1474228|dip:DIP-33195N - - - figure legend:Table 1, number 5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/05 2020/03/12 rogid:Wa2WXaNMh3W6gIjv4Zt6y9Ge4Vg9606 rogid:Y7lT7nyI9N/3imHOz8Ng+Zagf509606 rigid:Aa8Wf7IrB1bzXmaWZdV9Y23Y0aI false - mutation:328-328 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P00403 uniprotkb:Q92743 intact:EBI-2105756|uniprotkb:Q37526|ensembl:ENSP00000354876 intact:EBI-352256|uniprotkb:Q9UNS5|uniprotkb:D3DRE4|ensembl:ENSP00000357980 psi-mi:cox2_human(display_long)|uniprotkb:MT-CO2(gene name)|psi-mi:MT-CO2(display_short)|uniprotkb:COII(gene name synonym)|uniprotkb:COXII(gene name synonym)|uniprotkb:MTCO2(gene name synonym)|uniprotkb:Cytochrome c oxidase polypeptide II(gene name synonym)|uniprotkb:COX2(gene name synonym) psi-mi:htra1_human(display_long)|uniprotkb:HTRA1(gene name)|psi-mi:HTRA1(display_short)|uniprotkb:HTRA(gene name synonym)|uniprotkb:PRSS11(gene name synonym)|uniprotkb:High-temperature requirement A serine peptidase 1(gene name synonym)|uniprotkb:L56(gene name synonym)|uniprotkb:Serine protease 11(gene name synonym) psi-mi:"MI:0018"(two hybrid) Campioni et al. (2011) imex:IM-27784|pubmed:21622153 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-25468731|imex:IM-27784-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_003024029.1|ensembl:ENSG00000198712(gene)|ensembl:ENST00000361739(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0007595"(lactation)|go:"GO:0009409"(response to cold)|go:"GO:0010729"(positive regulation of hydrogen peroxide biosynthetic process)|go:"GO:0010940"(positive regulation of necrotic cell death)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042773"(ATP synthesis coupled electron transport)|go:"GO:0045277"(respiratory chain complex IV)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR001505("Copper centre Cu(A)")|interpro:IPR002429(Cytochrome c oxidase subunit II C-terminal)|interpro:IPR008972(Cupredoxin)|interpro:IPR011759(Cytochrome C oxidase subunit II, transmembrane region)|interpro:IPR014222(Cytochrome c oxidase, subunit II)|interpro:IPR034210|interpro:IPR036257|mint:P00403|rcsb pdb:3VRJ|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 refseq:NP_002766.1|ensembl:ENSG00000166033(gene)|ensembl:ENST00000368984(transcript)|go:"GO:0001890"(placenta development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050687"(negative regulation of defense response to virus)|go:"GO:0060718"(chorionic trophoblast cell differentiation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097187"(dentinogenesis)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058|interpro:IPR041489|rcsb pdb:2JOA|rcsb pdb:2YTW|rcsb pdb:3NUM|rcsb pdb:3NWU|rcsb pdb:3NZI|rcsb pdb:3TJN|rcsb pdb:3TJO|rcsb pdb:3TJQ|rcsb pdb:6Z0E|rcsb pdb:6Z0X|rcsb pdb:6Z0Y|reactome:R-HSA-1474228|dip:DIP-33195N - - - figure legend:Table 1, number 6|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/05 2020/03/12 rogid:NyMmciQe53E935KEZahz8cGPjIM9606 rogid:Y7lT7nyI9N/3imHOz8Ng+Zagf509606 rigid:Asasys2UnRmqWbufU7CiNUN6/Hg false - mutation:328-328 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P51808 uniprotkb:Q92743 intact:EBI-743027|ensembl:ENSP00000367841|uniprotkb:Q6ICS3 intact:EBI-352256|uniprotkb:Q9UNS5|uniprotkb:D3DRE4|ensembl:ENSP00000357980 psi-mi:dylt3_human(display_long)|uniprotkb:T-complex-associated testis-expressed 1-like(gene name synonym)|uniprotkb:Protein 91/23(gene name synonym)|uniprotkb:DYNLT3(gene name)|psi-mi:DYNLT3(display_short)|uniprotkb:TCTE1XL(gene name synonym)|uniprotkb:TCTE1L(gene name synonym) psi-mi:htra1_human(display_long)|uniprotkb:HTRA1(gene name)|psi-mi:HTRA1(display_short)|uniprotkb:HTRA(gene name synonym)|uniprotkb:PRSS11(gene name synonym)|uniprotkb:High-temperature requirement A serine peptidase 1(gene name synonym)|uniprotkb:L56(gene name synonym)|uniprotkb:Serine protease 11(gene name synonym) psi-mi:"MI:0018"(two hybrid) Campioni et al. (2011) imex:IM-27784|pubmed:21622153 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-25468737|imex:IM-27784-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000165169(gene)|ensembl:ENST00000378578(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0007049"(cell cycle)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0042802"(identical protein binding)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0051301"(cell division)|go:"GO:0061673"(mitotic spindle astral microtubule)|interpro:IPR005334(Tctex-1)|interpro:IPR038586|refseq:NP_006511.1 refseq:NP_002766.1|ensembl:ENSG00000166033(gene)|ensembl:ENST00000368984(transcript)|go:"GO:0001890"(placenta development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050687"(negative regulation of defense response to virus)|go:"GO:0060718"(chorionic trophoblast cell differentiation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097187"(dentinogenesis)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058|interpro:IPR041489|rcsb pdb:2JOA|rcsb pdb:2YTW|rcsb pdb:3NUM|rcsb pdb:3NWU|rcsb pdb:3NZI|rcsb pdb:3TJN|rcsb pdb:3TJO|rcsb pdb:3TJQ|rcsb pdb:6Z0E|rcsb pdb:6Z0X|rcsb pdb:6Z0Y|reactome:R-HSA-1474228|dip:DIP-33195N - - - figure legend:Table 1, number 7|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/05 2020/03/12 rogid:kmjc9zLx9d1OvhucGsEerIzDwwo9606 rogid:Y7lT7nyI9N/3imHOz8Ng+Zagf509606 rigid:6hOx1f1ZLpmck5lxLDtQjRqKgoI false - mutation:328-328 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9BTA9 uniprotkb:Q92743 intact:EBI-749118|intact:EBI-947208|uniprotkb:C9JBT9|uniprotkb:Q5JU75|uniprotkb:Q5JU77|uniprotkb:Q53EN9|uniprotkb:Q5VXK0|uniprotkb:Q5VXK2|uniprotkb:Q8TCK1|uniprotkb:Q96DP3|uniprotkb:Q96FW6|uniprotkb:Q96JI3|uniprotkb:A8K2A9|intact:EBI-1105304|uniprotkb:D3DRW5|uniprotkb:D3DRW6|uniprotkb:D3DRW7|ensembl:ENSP00000346986 intact:EBI-352256|uniprotkb:Q9UNS5|uniprotkb:D3DRE4|ensembl:ENSP00000357980 psi-mi:wac_human(display_long)|uniprotkb:WAC(gene name)|psi-mi:WAC(display_short)|uniprotkb:KIAA1844(gene name synonym) psi-mi:htra1_human(display_long)|uniprotkb:HTRA1(gene name)|psi-mi:HTRA1(display_short)|uniprotkb:HTRA(gene name synonym)|uniprotkb:PRSS11(gene name synonym)|uniprotkb:High-temperature requirement A serine peptidase 1(gene name synonym)|uniprotkb:L56(gene name synonym)|uniprotkb:Serine protease 11(gene name synonym) psi-mi:"MI:0018"(two hybrid) Campioni et al. (2011) imex:IM-27784|pubmed:21622153 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-25468743|imex:IM-27784-13 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011517793.1|refseq:NP_057712.2|refseq:NP_567823.1|refseq:NP_567822.1|ensembl:ENSG00000095787(gene)|ensembl:ENST00000354911(transcript)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071894"(histone H2B conserved C-terminal lysine ubiquitination)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR036020|interpro:IPR038867|reactome:R-HSA-8866654|go:"GO:0016607"(nuclear speck) refseq:NP_002766.1|ensembl:ENSG00000166033(gene)|ensembl:ENST00000368984(transcript)|go:"GO:0001890"(placenta development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050687"(negative regulation of defense response to virus)|go:"GO:0060718"(chorionic trophoblast cell differentiation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097187"(dentinogenesis)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058|interpro:IPR041489|rcsb pdb:2JOA|rcsb pdb:2YTW|rcsb pdb:3NUM|rcsb pdb:3NWU|rcsb pdb:3NZI|rcsb pdb:3TJN|rcsb pdb:3TJO|rcsb pdb:3TJQ|rcsb pdb:6Z0E|rcsb pdb:6Z0X|rcsb pdb:6Z0Y|reactome:R-HSA-1474228|dip:DIP-33195N - - - figure legend:Table 1, number 8|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/05 2020/03/12 rogid:TuCxRb98Y5EGRbK1RRNMi/VnXV89606 rogid:Y7lT7nyI9N/3imHOz8Ng+Zagf509606 rigid:epNjGlVKu8ciOlyNTpz4vj4YuTQ false - mutation:328-328 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:O00303 uniprotkb:Q92743 intact:EBI-711990|ensembl:ENSP00000431800|ensembl:ENSP00000499218|uniprotkb:Q6IB45|uniprotkb:Q8N978|uniprotkb:A8K0S2 intact:EBI-352256|uniprotkb:Q9UNS5|uniprotkb:D3DRE4|ensembl:ENSP00000357980 psi-mi:eif3f_human(display_long)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 5(gene name synonym)|uniprotkb:eIF-3-epsilon(gene name synonym)|uniprotkb:eIF3 p47(gene name synonym)|uniprotkb:EIF3F(gene name)|psi-mi:EIF3F(display_short)|uniprotkb:EIF3S5(gene name synonym)|uniprotkb:Deubiquitinating enzyme eIF3f(gene name synonym) psi-mi:htra1_human(display_long)|uniprotkb:HTRA1(gene name)|psi-mi:HTRA1(display_short)|uniprotkb:HTRA(gene name synonym)|uniprotkb:PRSS11(gene name synonym)|uniprotkb:High-temperature requirement A serine peptidase 1(gene name synonym)|uniprotkb:L56(gene name synonym)|uniprotkb:Serine protease 11(gene name synonym) psi-mi:"MI:0018"(two hybrid) Campioni et al. (2011) imex:IM-27784|pubmed:21622153 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-25468749|imex:IM-27784-15 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000175390(gene)|ensembl:ENST00000533626(transcript)|ensembl:ENST00000651655(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0075522"(IRES-dependent viral translational initiation)|go:"GO:0101005"(deubiquitinase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR024969|interpro:IPR027531|interpro:IPR037518|mint:O00303|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|refseq:NP_003745.1|dip:DIP-35580N refseq:NP_002766.1|ensembl:ENSG00000166033(gene)|ensembl:ENST00000368984(transcript)|go:"GO:0001890"(placenta development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050687"(negative regulation of defense response to virus)|go:"GO:0060718"(chorionic trophoblast cell differentiation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097187"(dentinogenesis)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058|interpro:IPR041489|rcsb pdb:2JOA|rcsb pdb:2YTW|rcsb pdb:3NUM|rcsb pdb:3NWU|rcsb pdb:3NZI|rcsb pdb:3TJN|rcsb pdb:3TJO|rcsb pdb:3TJQ|rcsb pdb:6Z0E|rcsb pdb:6Z0X|rcsb pdb:6Z0Y|reactome:R-HSA-1474228|dip:DIP-33195N - - - figure legend:Table 1, number 9|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/05 2020/03/12 rogid:dpH1pTcPshcrSjNCdPPnkYiW0YU9606 rogid:Y7lT7nyI9N/3imHOz8Ng+Zagf509606 rigid:Nmj906YyGtVU3zyX4oOh86FVEIE false - mutation:328-328 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P49815-3 uniprotkb:Q92743 intact:EBI-25468762|ensembl:ENSP00000494514 intact:EBI-352256|uniprotkb:Q9UNS5|uniprotkb:D3DRE4|ensembl:ENSP00000357980 psi-mi:p49815-3(display_long)|uniprotkb:Tuberous sclerosis 2 protein(gene name synonym)|uniprotkb:TSC2(gene name)|psi-mi:TSC2(display_short)|uniprotkb:TSC4(gene name synonym) psi-mi:htra1_human(display_long)|uniprotkb:HTRA1(gene name)|psi-mi:HTRA1(display_short)|uniprotkb:HTRA(gene name synonym)|uniprotkb:PRSS11(gene name synonym)|uniprotkb:High-temperature requirement A serine peptidase 1(gene name synonym)|uniprotkb:L56(gene name synonym)|uniprotkb:Serine protease 11(gene name synonym) psi-mi:"MI:0018"(two hybrid) Campioni et al. (2011) imex:IM-27784|pubmed:21622153 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-25468755|imex:IM-27784-23 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000103197(gene)|ensembl:ENST00000642936(transcript)|intact:EBI-396587(isoform-parent) refseq:NP_002766.1|ensembl:ENSG00000166033(gene)|ensembl:ENST00000368984(transcript)|go:"GO:0001890"(placenta development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050687"(negative regulation of defense response to virus)|go:"GO:0060718"(chorionic trophoblast cell differentiation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097187"(dentinogenesis)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058|interpro:IPR041489|rcsb pdb:2JOA|rcsb pdb:2YTW|rcsb pdb:3NUM|rcsb pdb:3NWU|rcsb pdb:3NZI|rcsb pdb:3TJN|rcsb pdb:3TJO|rcsb pdb:3TJQ|rcsb pdb:6Z0E|rcsb pdb:6Z0X|rcsb pdb:6Z0Y|reactome:R-HSA-1474228|dip:DIP-33195N - - - figure legend:Table 1, number 10|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/05 2020/03/12 rogid:0X7TR6tVZcwI7CgXeipic8xsIEs9606 rogid:Y7lT7nyI9N/3imHOz8Ng+Zagf509606 rigid:VhgFjCVdj5kwzq6Tj0dksZcQzOg false - mutation:328-328 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q76KP1 uniprotkb:Q92743 intact:EBI-21379362|ensembl:ENSP00000328277|uniprotkb:Q96LV2 intact:EBI-352256|uniprotkb:Q9UNS5|uniprotkb:D3DRE4|ensembl:ENSP00000357980 psi-mi:b4gn4_human(display_long)|uniprotkb:B4GALNT4(gene name)|psi-mi:B4GALNT4(display_short)|uniprotkb:Beta-1,4-N-acetylgalactosaminyltransferase IV(gene name synonym) psi-mi:htra1_human(display_long)|uniprotkb:HTRA1(gene name)|psi-mi:HTRA1(display_short)|uniprotkb:HTRA(gene name synonym)|uniprotkb:PRSS11(gene name synonym)|uniprotkb:High-temperature requirement A serine peptidase 1(gene name synonym)|uniprotkb:L56(gene name synonym)|uniprotkb:Serine protease 11(gene name synonym) psi-mi:"MI:0018"(two hybrid) Campioni et al. (2011) imex:IM-27784|pubmed:21622153 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-25468770|imex:IM-27784-17 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000182272(gene)|ensembl:ENST00000329962(transcript)|go:"GO:0008376"(acetylgalactosaminyltransferase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0033842"(N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity)|interpro:IPR008428(Chondroitin N-acetylgalactosaminyltransferase)|interpro:IPR011658(PA14)|interpro:IPR029044|interpro:IPR037524|refseq:NP_848632.2 refseq:NP_002766.1|ensembl:ENSG00000166033(gene)|ensembl:ENST00000368984(transcript)|go:"GO:0001890"(placenta development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050687"(negative regulation of defense response to virus)|go:"GO:0060718"(chorionic trophoblast cell differentiation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097187"(dentinogenesis)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058|interpro:IPR041489|rcsb pdb:2JOA|rcsb pdb:2YTW|rcsb pdb:3NUM|rcsb pdb:3NWU|rcsb pdb:3NZI|rcsb pdb:3TJN|rcsb pdb:3TJO|rcsb pdb:3TJQ|rcsb pdb:6Z0E|rcsb pdb:6Z0X|rcsb pdb:6Z0Y|reactome:R-HSA-1474228|dip:DIP-33195N - - - figure legend:Table 1, number 11|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/05 2020/03/12 rogid:S2/HGYyqSEoLQ9YC0W/BM5Y9wqU9606 rogid:Y7lT7nyI9N/3imHOz8Ng+Zagf509606 rigid:tspwvcQz8/pU0Wfuq8/3glzsK4Q false sufficient binding region:726-1039(AK057774) mutation:328-328 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9BRK4 uniprotkb:Q92743 intact:EBI-741037|ensembl:ENSP00000359240|ensembl:ENSP00000359243|uniprotkb:Q8N3I0|uniprotkb:Q96J79|uniprotkb:Q96JL2|uniprotkb:B1AL14|uniprotkb:D3DR72 intact:EBI-352256|uniprotkb:Q9UNS5|uniprotkb:D3DRE4|ensembl:ENSP00000357980 psi-mi:lzts2_human(display_long)|uniprotkb:Protein LAPSER1(gene name synonym)|uniprotkb:LZTS2(gene name)|psi-mi:LZTS2(display_short)|uniprotkb:KIAA1813(gene name synonym)|uniprotkb:LAPSER1(gene name synonym) psi-mi:htra1_human(display_long)|uniprotkb:HTRA1(gene name)|psi-mi:HTRA1(display_short)|uniprotkb:HTRA(gene name synonym)|uniprotkb:PRSS11(gene name synonym)|uniprotkb:High-temperature requirement A serine peptidase 1(gene name synonym)|uniprotkb:L56(gene name synonym)|uniprotkb:Serine protease 11(gene name synonym) psi-mi:"MI:0018"(two hybrid) Campioni et al. (2011) imex:IM-27784|pubmed:21622153 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-25468779|imex:IM-27784-25 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_115805.1|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030496"(midbody)|go:"GO:0031982"(vesicle)|go:"GO:0051013"(microtubule severing)|go:"GO:0051168"(nuclear export)|go:"GO:0051255"(spindle midzone assembly)|go:"GO:0060682"(primary ureteric bud growth)|go:"GO:0072197"(ureter morphogenesis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|interpro:IPR028597|mint:Q9BRK4|ensembl:ENSG00000107816(gene)|ensembl:ENST00000370220(transcript)|ensembl:ENST00000370223(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0008285"(negative regulation of cell population proliferation)|refseq:XP_016872269.1|refseq:NP_001305028.1|refseq:NP_001305029.1|refseq:NP_001305030.1|refseq:XP_005270279.1 refseq:NP_002766.1|ensembl:ENSG00000166033(gene)|ensembl:ENST00000368984(transcript)|go:"GO:0001890"(placenta development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050687"(negative regulation of defense response to virus)|go:"GO:0060718"(chorionic trophoblast cell differentiation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097187"(dentinogenesis)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058|interpro:IPR041489|rcsb pdb:2JOA|rcsb pdb:2YTW|rcsb pdb:3NUM|rcsb pdb:3NWU|rcsb pdb:3NZI|rcsb pdb:3TJN|rcsb pdb:3TJO|rcsb pdb:3TJQ|rcsb pdb:6Z0E|rcsb pdb:6Z0X|rcsb pdb:6Z0Y|reactome:R-HSA-1474228|dip:DIP-33195N - - - figure legend:Table 1, number 12|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/03/05 2020/03/12 rogid:OaMJmnmfm6JniKUJeyg7fS6zRcw9606 rogid:Y7lT7nyI9N/3imHOz8Ng+Zagf509606 rigid:mvsE08mEuGhoMjh2kvzu3bK8YmM false - mutation:328-328 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q92743 - intact:EBI-352256|uniprotkb:Q9UNS5|uniprotkb:D3DRE4|ensembl:ENSP00000357980 - psi-mi:htra1_human(display_long)|uniprotkb:HTRA1(gene name)|psi-mi:HTRA1(display_short)|uniprotkb:HTRA(gene name synonym)|uniprotkb:PRSS11(gene name synonym)|uniprotkb:High-temperature requirement A serine peptidase 1(gene name synonym)|uniprotkb:L56(gene name synonym)|uniprotkb:Serine protease 11(gene name synonym) - psi-mi:"MI:0435"(protease assay) Campioni et al. (2011) imex:IM-27784|pubmed:21622153 taxid:9606(human)|taxid:9606(Homo sapiens) - psi-mi:"MI:0570"(protein cleavage) psi-mi:"MI:0469"(IntAct) intact:EBI-25468915|imex:IM-27784-19 - - psi-mi:"MI:0898"(putative self) - psi-mi:"MI:0898"(putative self) - psi-mi:"MI:0326"(protein) - refseq:NP_002766.1|ensembl:ENSG00000166033(gene)|ensembl:ENST00000368984(transcript)|go:"GO:0001890"(placenta development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050687"(negative regulation of defense response to virus)|go:"GO:0060718"(chorionic trophoblast cell differentiation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097187"(dentinogenesis)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058|interpro:IPR041489|rcsb pdb:2JOA|rcsb pdb:2YTW|rcsb pdb:3NUM|rcsb pdb:3NWU|rcsb pdb:3NZI|rcsb pdb:3TJN|rcsb pdb:3TJO|rcsb pdb:3TJQ|rcsb pdb:6Z0E|rcsb pdb:6Z0X|rcsb pdb:6Z0Y|reactome:R-HSA-1474228|dip:DIP-33195N - - - - figure legend:2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/03/05 2020/03/12 rogid:Y7lT7nyI9N/3imHOz8Ng+Zagf509606 - - false 35s radiolabel:?-?|mutation disrupting interaction rate:328-328 - - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) -