#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
matrixdb:MULT_82_human	uniprotkb:P10124	intact:EBI-6264901|reactome:R-HSA-173579|wwpdb:1PK6|wwpdb:2wnv|wwpdb:2jg8|wwpdb:2jg9|wwpdb:2wnu|reactome:R-HSA-173588	intact:EBI-744915|uniprotkb:Q5VW06|uniprotkb:B2R4L7|ensembl:ENSP00000242465	psi-mi:c1q_human(display_short)|psi-mi:MULT_82_human(display_long)|intact:Complement component C1q complex(complex recommended name)|intact:C1q(complex synonym)|intact:Complement 1q(complex synonym)|intact:C1QA-C1QB-C1QC complex(complex synonym)|intact:"6xC1QA:6xC1QB:6xC1QC"(complex systematic name)	psi-mi:srgn_human(display_long)|uniprotkb:Secretory granule proteoglycan core protein(gene name synonym)|uniprotkb:Platelet proteoglycan core protein(gene name synonym)|uniprotkb:SRGN(gene name)|psi-mi:SRGN(display_short)|uniprotkb:PRG(gene name synonym)|uniprotkb:PRG1(gene name synonym)|uniprotkb:Hematopoietic proteoglycan core protein(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Skliris et al. (2011)	pubmed:21268013|imex:IM-28597	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26573661|imex:IM-28597-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:0326"(protein)	go:"GO:0005509"(calcium ion binding)|go:"GO:0019865"(immunoglobulin binding)|efo:"MONDO:0013343"(see-also)|pubmed:28601358(see-also)|pubmed:22536204(see-also)|intact:EBI-6264878(exp-evidence)|evidence ontology:"ECO:0000353"|complex portal:CPX-1919(complex-primary)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0005576"(extracellular region)|pubmed:20548024(see-also)|pubmed:29449492(see-also)|pubmed:18250442(see-also)|go:"GO:0062167"(complement component C1q complex)|pubmed:31165008(see-also)|pubmed:27914690(see-also)|pubmed:26489954(see-also)	refseq:NP_002718.2|go:"GO:0042629"(mast cell granule)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:0140507"(granzyme-mediated programmed cell death signaling pathway)|interpro:IPR007455(Serglycin)|mint:P10124|reactome:R-HSA-114608|ensembl:ENSG00000122862(gene)|ensembl:ENST00000242465(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006915"(apoptotic process)|go:"GO:0016485"(protein processing)|go:"GO:0030141"(secretory granule)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0033363"(secretory granule organization)|go:"GO:0033364"(mast cell secretory granule organization)|go:"GO:0033371"(T cell secretory granule organization)|go:"GO:0033373"(maintenance of protease location in mast cell secretory granule)|go:"GO:0033382"(maintenance of granzyme B location in T cell secretory granule)|refseq:NP_001307982.1|refseq:NP_001307983.1|refseq:XP_016871881.1	-	disease:"Complement component C1q deficiency (C1QD) [MONDO:0013343]: a disorder caused by impaired activation of the complement classical pathway. It generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis."|complex-properties:The complex comprises of six heterotrimeric collagen-like triple helices, formed from triplets of the A, B, and C chains, that associate in their N-terminal half to form a stalk, then diverge to form individual stems, each terminating in a C-terminal globular domain. Each of the six heterotrimeric globular heads or domains is made up of the globular domains from one A, one B, and one C chain, each of which in turn has its own ligand specificity. The six collagen-like stalks appear to be fibril-like and exist in the central region. The collagen-like region and the globular heads can independently interact with a multiplicity of biological structures including pathogen-associated and cell associated molecules, also each of the individual globular head domains is capable of independently interacting with specific ligands. Chains A and B are disulfide-linked whilst the C chain forms a disulfide bond with the C chain of the next strand.     Molecular weight 460 kDa.|curated-complex:"Recognition unit of the classical pathway of complement which associates with the Ca2+ - dependent C1r(2)-C1s(2) tetramer to form C1 (CPX-1920), the first component of the classical complement system. The complex's role in C1 is the recognition of immune complexes, or other molecules, which trigger the classical pathway of the complement system. Independent of complement activation C1q appears to have additional roles in homeostasis and cellular development, superoxide (O2-) production by neutrophils, blood coagulation and neurological synapse pruning."|complex-assembly:Heterooctadecamer	-	figure legend:4A, 5C, 6|antagonist:Increasing ionic strength; an above physiological concentration of sodium choloride.|antagonist:Chondroitinase ABC treatment;removal of chondroitin sulfate from Serglycin.|comment:"Serglycin lacking its  chondroitin sulfate (CS) chains still bound C1q from solution but this interaction was clearly diminished."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/18	2020/12/29	-	rogid:fc8Rv0C285T5/uBa6eAVR4lvW3s9606	-	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P11226	uniprotkb:P10124	intact:EBI-5325353|ensembl:ENSP00000363079|ensembl:ENSP00000502615|ensembl:ENSP00000502789|uniprotkb:Q4VB12|uniprotkb:Q4VB13|uniprotkb:Q86SI4|uniprotkb:Q96KE4|uniprotkb:Q96TF7|uniprotkb:Q96TF8|uniprotkb:Q96TF9|uniprotkb:Q4VB14|uniprotkb:Q5SQS3	intact:EBI-744915|uniprotkb:Q5VW06|uniprotkb:B2R4L7|ensembl:ENSP00000242465	psi-mi:mbl2_human(display_long)|uniprotkb:MBL2(gene name)|psi-mi:MBL2(display_short)|uniprotkb:COLEC1(gene name synonym)|uniprotkb:MBL(gene name synonym)|uniprotkb:Collectin-1(gene name synonym)|uniprotkb:MBP1(gene name synonym)|uniprotkb:Mannan-binding protein(gene name synonym)|uniprotkb:Mannose-binding lectin(gene name synonym)	psi-mi:srgn_human(display_long)|uniprotkb:Secretory granule proteoglycan core protein(gene name synonym)|uniprotkb:Platelet proteoglycan core protein(gene name synonym)|uniprotkb:SRGN(gene name)|psi-mi:SRGN(display_short)|uniprotkb:PRG(gene name synonym)|uniprotkb:PRG1(gene name synonym)|uniprotkb:Hematopoietic proteoglycan core protein(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Skliris et al. (2011)	pubmed:21268013|imex:IM-28597	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26573678|imex:IM-28597-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000165471(gene)|ensembl:ENST00000373968(transcript)|ensembl:ENST00000674931(transcript)|ensembl:ENST00000675947(transcript)|go:"GO:0001867"(complement activation, lectin pathway)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005537"(mannose binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0006953"(acute-phase response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008228"(opsonization)|go:"GO:0009986"(cell surface)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048525"(negative regulation of viral process)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR001304(C-type lectin)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR016186(C-type lectin-like)|refseq:XP_011538118.1|interpro:IPR018378|interpro:IPR033990|interpro:IPR037570|rcsb pdb:1HUP|interpro:IPR016187(C-type lectin fold)|reactome:R-HSA-166662|reactome:R-HSA-166663|refseq:NP_000233.1|refseq:XP_006717924.1|dip:DIP-61381N	refseq:NP_002718.2|go:"GO:0042629"(mast cell granule)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:0140507"(granzyme-mediated programmed cell death signaling pathway)|interpro:IPR007455(Serglycin)|mint:P10124|reactome:R-HSA-114608|ensembl:ENSG00000122862(gene)|ensembl:ENST00000242465(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006915"(apoptotic process)|go:"GO:0016485"(protein processing)|go:"GO:0030141"(secretory granule)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0033363"(secretory granule organization)|go:"GO:0033364"(mast cell secretory granule organization)|go:"GO:0033371"(T cell secretory granule organization)|go:"GO:0033373"(maintenance of protease location in mast cell secretory granule)|go:"GO:0033382"(maintenance of granzyme B location in T cell secretory granule)|refseq:NP_001307982.1|refseq:NP_001307983.1|refseq:XP_016871881.1	-	-	-	figure legend:4D, 5D, 6|antagonist:Increasing ionic strength; an above physiological concentration of sodium choloride.|antagonist:"EDTA (CHEBI:42191)"|antagonist:Chondroitinase ABC treatment;removal of chondroitin sulfate from Serglycin.|comment:"After removal of the chondroitin sulfate (CS) chains  from Serglycin with digestion by chondroitinase ABC, less bound MBL was detected compared with that bound to intact Serglycin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/18	2020/12/29	rogid:uo0RM88uw3otObIVnOhUcOfW8yo9606	rogid:fc8Rv0C285T5/uBa6eAVR4lvW3s9606	rigid:cIwQdSz1TfptSlAWZu66MPav6Vk	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P11226	uniprotkb:P21793	intact:EBI-5325353|ensembl:ENSP00000363079|ensembl:ENSP00000502615|ensembl:ENSP00000502789|uniprotkb:Q4VB12|uniprotkb:Q4VB13|uniprotkb:Q86SI4|uniprotkb:Q96KE4|uniprotkb:Q96TF7|uniprotkb:Q96TF8|uniprotkb:Q96TF9|uniprotkb:Q4VB14|uniprotkb:Q5SQS3	intact:EBI-26573687|ensembl:ENSBTAP00000004562|uniprotkb:Q3MHN1|uniprotkb:Q5U7W0|uniprotkb:Q861V7|uniprotkb:Q862D9|uniprotkb:Q862E8|uniprotkb:Q862L4|uniprotkb:Q862R5	psi-mi:mbl2_human(display_long)|uniprotkb:MBL2(gene name)|psi-mi:MBL2(display_short)|uniprotkb:COLEC1(gene name synonym)|uniprotkb:MBL(gene name synonym)|uniprotkb:Collectin-1(gene name synonym)|uniprotkb:MBP1(gene name synonym)|uniprotkb:Mannan-binding protein(gene name synonym)|uniprotkb:Mannose-binding lectin(gene name synonym)	psi-mi:pgs2_bovin(display_long)|uniprotkb:Bone proteoglycan II(gene name synonym)|uniprotkb:PG-S2(gene name synonym)|uniprotkb:DCN(gene name)|psi-mi:DCN(display_short)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Skliris et al. (2011)	pubmed:21268013|imex:IM-28597	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26573683|imex:IM-28597-23	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000165471(gene)|ensembl:ENST00000373968(transcript)|ensembl:ENST00000674931(transcript)|ensembl:ENST00000675947(transcript)|go:"GO:0001867"(complement activation, lectin pathway)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005537"(mannose binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0006953"(acute-phase response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008228"(opsonization)|go:"GO:0009986"(cell surface)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048525"(negative regulation of viral process)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR001304(C-type lectin)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR016186(C-type lectin-like)|refseq:XP_011538118.1|interpro:IPR018378|interpro:IPR033990|interpro:IPR037570|rcsb pdb:1HUP|interpro:IPR016187(C-type lectin fold)|reactome:R-HSA-166662|reactome:R-HSA-166663|refseq:NP_000233.1|refseq:XP_006717924.1|dip:DIP-61381N	ensembl:ENSBTAG00000003505(gene)|ensembl:ENSBTAT00000004562(transcript)|go:"GO:0005518"(collagen binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005615"(extracellular space)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019800"(peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan)|go:"GO:0030021"(extracellular matrix structural constituent conferring compression resistance)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0098633"(collagen fibril binding)|go:"GO:1900747"(negative regulation of vascular endothelial growth factor signaling pathway)|go:"GO:1904027"(negative regulation of collagen fibril organization)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR016352(Small leucine-rich proteoglycan, class I, decorin/asporin/byglycan)|interpro:IPR028549|interpro:IPR032675|rcsb pdb:1XCD|rcsb pdb:1XEC|rcsb pdb:1XKU|reactome:R-BTA-1474228|reactome:R-BTA-1971475|reactome:R-BTA-2022870|reactome:R-BTA-2022923|reactome:R-BTA-2024101|reactome:R-BTA-3000178|refseq:NP_776331.2|refseq:XP_005206096.1	-	-	-	figure legend:4D, 5D|antagonist:Increasing ionic strength; an above physiological concentration of sodium choloride.|antagonist:"EDTA (CHEBI:42191)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/18	2020/12/29	rogid:uo0RM88uw3otObIVnOhUcOfW8yo9606	rogid:S6JEGFhRFAh8JgAqovY8LajkO9s9913	rigid:U9oSGO3GyYPcqjLJuiJJVD6v+lk	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
matrixdb:MULT_82_human	uniprotkb:P10124	intact:EBI-6264901|reactome:R-HSA-173579|wwpdb:1PK6|wwpdb:2wnv|wwpdb:2jg8|wwpdb:2jg9|wwpdb:2wnu|reactome:R-HSA-173588	intact:EBI-744915|uniprotkb:Q5VW06|uniprotkb:B2R4L7|ensembl:ENSP00000242465	psi-mi:c1q_human(display_short)|psi-mi:MULT_82_human(display_long)|intact:Complement component C1q complex(complex recommended name)|intact:C1q(complex synonym)|intact:Complement 1q(complex synonym)|intact:C1QA-C1QB-C1QC complex(complex synonym)|intact:"6xC1QA:6xC1QB:6xC1QC"(complex systematic name)	psi-mi:srgn_human(display_long)|uniprotkb:Secretory granule proteoglycan core protein(gene name synonym)|uniprotkb:Platelet proteoglycan core protein(gene name synonym)|uniprotkb:SRGN(gene name)|psi-mi:SRGN(display_short)|uniprotkb:PRG(gene name synonym)|uniprotkb:PRG1(gene name synonym)|uniprotkb:Hematopoietic proteoglycan core protein(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Skliris et al. (2011)	pubmed:21268013|imex:IM-28597	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26573736|imex:IM-28597-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:0326"(protein)	go:"GO:0005509"(calcium ion binding)|go:"GO:0019865"(immunoglobulin binding)|efo:"MONDO:0013343"(see-also)|pubmed:28601358(see-also)|pubmed:22536204(see-also)|intact:EBI-6264878(exp-evidence)|evidence ontology:"ECO:0000353"|complex portal:CPX-1919(complex-primary)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0005576"(extracellular region)|pubmed:20548024(see-also)|pubmed:29449492(see-also)|pubmed:18250442(see-also)|go:"GO:0062167"(complement component C1q complex)|pubmed:31165008(see-also)|pubmed:27914690(see-also)|pubmed:26489954(see-also)	refseq:NP_002718.2|go:"GO:0042629"(mast cell granule)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:0140507"(granzyme-mediated programmed cell death signaling pathway)|interpro:IPR007455(Serglycin)|mint:P10124|reactome:R-HSA-114608|ensembl:ENSG00000122862(gene)|ensembl:ENST00000242465(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006915"(apoptotic process)|go:"GO:0016485"(protein processing)|go:"GO:0030141"(secretory granule)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0033363"(secretory granule organization)|go:"GO:0033364"(mast cell secretory granule organization)|go:"GO:0033371"(T cell secretory granule organization)|go:"GO:0033373"(maintenance of protease location in mast cell secretory granule)|go:"GO:0033382"(maintenance of granzyme B location in T cell secretory granule)|refseq:NP_001307982.1|refseq:NP_001307983.1|refseq:XP_016871881.1	-	disease:"Complement component C1q deficiency (C1QD) [MONDO:0013343]: a disorder caused by impaired activation of the complement classical pathway. It generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis."|complex-properties:The complex comprises of six heterotrimeric collagen-like triple helices, formed from triplets of the A, B, and C chains, that associate in their N-terminal half to form a stalk, then diverge to form individual stems, each terminating in a C-terminal globular domain. Each of the six heterotrimeric globular heads or domains is made up of the globular domains from one A, one B, and one C chain, each of which in turn has its own ligand specificity. The six collagen-like stalks appear to be fibril-like and exist in the central region. The collagen-like region and the globular heads can independently interact with a multiplicity of biological structures including pathogen-associated and cell associated molecules, also each of the individual globular head domains is capable of independently interacting with specific ligands. Chains A and B are disulfide-linked whilst the C chain forms a disulfide bond with the C chain of the next strand.     Molecular weight 460 kDa.|curated-complex:"Recognition unit of the classical pathway of complement which associates with the Ca2+ - dependent C1r(2)-C1s(2) tetramer to form C1 (CPX-1920), the first component of the classical complement system. The complex's role in C1 is the recognition of immune complexes, or other molecules, which trigger the classical pathway of the complement system. Independent of complement activation C1q appears to have additional roles in homeostasis and cellular development, superoxide (O2-) production by neutrophils, blood coagulation and neurological synapse pruning."|complex-assembly:Heterooctadecamer	-	figure legend:5A|comment:Serglycin bound to the stalk regions of C1q.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/18	2020/12/29	-	rogid:fc8Rv0C285T5/uBa6eAVR4lvW3s9606	-	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
matrixdb:MULT_82_human	uniprotkb:P21809	intact:EBI-6264901|reactome:R-HSA-173579|wwpdb:1PK6|wwpdb:2wnv|wwpdb:2jg8|wwpdb:2jg9|wwpdb:2wnu|reactome:R-HSA-173588	intact:EBI-2566331|uniprotkb:Q5BIM3|uniprotkb:P79259|uniprotkb:Q17QB0|ensembl:ENSBTAP00000044462	psi-mi:c1q_human(display_short)|psi-mi:MULT_82_human(display_long)|intact:Complement component C1q complex(complex recommended name)|intact:C1q(complex synonym)|intact:Complement 1q(complex synonym)|intact:C1QA-C1QB-C1QC complex(complex synonym)|intact:"6xC1QA:6xC1QB:6xC1QC"(complex systematic name)	psi-mi:pgs1_bovin(display_long)|uniprotkb:Bone/cartilage proteoglycan I(gene name synonym)|uniprotkb:Leucine-rich PG I(gene name synonym)|uniprotkb:PG-S1(gene name synonym)|uniprotkb:BGN(gene name)|psi-mi:BGN(display_short)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Skliris et al. (2011)	pubmed:21268013|imex:IM-28597	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26573742|imex:IM-28597-25	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:0326"(protein)	go:"GO:0005509"(calcium ion binding)|go:"GO:0019865"(immunoglobulin binding)|efo:"MONDO:0013343"(see-also)|pubmed:28601358(see-also)|pubmed:22536204(see-also)|intact:EBI-6264878(exp-evidence)|evidence ontology:"ECO:0000353"|complex portal:CPX-1919(complex-primary)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0005576"(extracellular region)|pubmed:20548024(see-also)|pubmed:29449492(see-also)|pubmed:18250442(see-also)|go:"GO:0062167"(complement component C1q complex)|pubmed:31165008(see-also)|pubmed:27914690(see-also)|pubmed:26489954(see-also)	refseq:NP_847888.2|ensembl:ENSBTAG00000005250(gene)|ensembl:ENSBTAT00000047242(transcript)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0009986"(cell surface)|go:"GO:0019800"(peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan)|go:"GO:0030133"(transport vesicle)|go:"GO:0031012"(extracellular matrix)|go:"GO:0042383"(sarcolemma)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0060348"(bone development)|go:"GO:0061975"(articular cartilage development)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR016352(Small leucine-rich proteoglycan, class I, decorin/asporin/byglycan)|interpro:IPR028547|interpro:IPR032675|rcsb pdb:2FT3|reactome:R-BTA-1971475|reactome:R-BTA-2022870|reactome:R-BTA-2022923|reactome:R-BTA-2024101|reactome:R-BTA-3000178|refseq:XP_005227715.1	-	disease:"Complement component C1q deficiency (C1QD) [MONDO:0013343]: a disorder caused by impaired activation of the complement classical pathway. It generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis."|complex-properties:The complex comprises of six heterotrimeric collagen-like triple helices, formed from triplets of the A, B, and C chains, that associate in their N-terminal half to form a stalk, then diverge to form individual stems, each terminating in a C-terminal globular domain. Each of the six heterotrimeric globular heads or domains is made up of the globular domains from one A, one B, and one C chain, each of which in turn has its own ligand specificity. The six collagen-like stalks appear to be fibril-like and exist in the central region. The collagen-like region and the globular heads can independently interact with a multiplicity of biological structures including pathogen-associated and cell associated molecules, also each of the individual globular head domains is capable of independently interacting with specific ligands. Chains A and B are disulfide-linked whilst the C chain forms a disulfide bond with the C chain of the next strand.     Molecular weight 460 kDa.|curated-complex:"Recognition unit of the classical pathway of complement which associates with the Ca2+ - dependent C1r(2)-C1s(2) tetramer to form C1 (CPX-1920), the first component of the classical complement system. The complex's role in C1 is the recognition of immune complexes, or other molecules, which trigger the classical pathway of the complement system. Independent of complement activation C1q appears to have additional roles in homeostasis and cellular development, superoxide (O2-) production by neutrophils, blood coagulation and neurological synapse pruning."|complex-assembly:Heterooctadecamer	-	figure legend:5A|comment:Biglycan bound to the stalk regions of C1q.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/18	2020/12/29	-	rogid:PGameAxY3dkRrmjf2gLz3I+vUcs9913	-	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
matrixdb:MULT_82_human	uniprotkb:P13605	intact:EBI-6264901|reactome:R-HSA-173579|wwpdb:1PK6|wwpdb:2wnv|wwpdb:2jg8|wwpdb:2jg9|wwpdb:2wnu|reactome:R-HSA-173588	intact:EBI-5281124|uniprotkb:A7E3X1|uniprotkb:Q3SWX6|ensembl:ENSBTAP00000019854	psi-mi:c1q_human(display_short)|psi-mi:MULT_82_human(display_long)|intact:Complement component C1q complex(complex recommended name)|intact:C1q(complex synonym)|intact:Complement 1q(complex synonym)|intact:C1QA-C1QB-C1QC complex(complex synonym)|intact:"6xC1QA:6xC1QB:6xC1QC"(complex systematic name)	psi-mi:fmod_bovin(display_long)|uniprotkb:FMOD(gene name)|psi-mi:FMOD(display_short)|uniprotkb:Collagen-binding 59 kDa protein(gene name synonym)|uniprotkb:Keratan sulfate proteoglycan fibromodulin(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Skliris et al. (2011)	pubmed:21268013|imex:IM-28597	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26573748|imex:IM-28597-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:0326"(protein)	go:"GO:0005509"(calcium ion binding)|go:"GO:0019865"(immunoglobulin binding)|efo:"MONDO:0013343"(see-also)|pubmed:28601358(see-also)|pubmed:22536204(see-also)|intact:EBI-6264878(exp-evidence)|evidence ontology:"ECO:0000353"|complex portal:CPX-1919(complex-primary)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0005576"(extracellular region)|pubmed:20548024(see-also)|pubmed:29449492(see-also)|pubmed:18250442(see-also)|go:"GO:0062167"(complement component C1q complex)|pubmed:31165008(see-also)|pubmed:27914690(see-also)|pubmed:26489954(see-also)	refseq:NP_776483.1|ensembl:ENSBTAG00000014912(gene)|ensembl:ENSBTAT00000019854(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR027215|interpro:IPR032675|reactome:R-BTA-2022854|reactome:R-BTA-2022857	-	disease:"Complement component C1q deficiency (C1QD) [MONDO:0013343]: a disorder caused by impaired activation of the complement classical pathway. It generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis."|complex-properties:The complex comprises of six heterotrimeric collagen-like triple helices, formed from triplets of the A, B, and C chains, that associate in their N-terminal half to form a stalk, then diverge to form individual stems, each terminating in a C-terminal globular domain. Each of the six heterotrimeric globular heads or domains is made up of the globular domains from one A, one B, and one C chain, each of which in turn has its own ligand specificity. The six collagen-like stalks appear to be fibril-like and exist in the central region. The collagen-like region and the globular heads can independently interact with a multiplicity of biological structures including pathogen-associated and cell associated molecules, also each of the individual globular head domains is capable of independently interacting with specific ligands. Chains A and B are disulfide-linked whilst the C chain forms a disulfide bond with the C chain of the next strand.     Molecular weight 460 kDa.|curated-complex:"Recognition unit of the classical pathway of complement which associates with the Ca2+ - dependent C1r(2)-C1s(2) tetramer to form C1 (CPX-1920), the first component of the classical complement system. The complex's role in C1 is the recognition of immune complexes, or other molecules, which trigger the classical pathway of the complement system. Independent of complement activation C1q appears to have additional roles in homeostasis and cellular development, superoxide (O2-) production by neutrophils, blood coagulation and neurological synapse pruning."|complex-assembly:Heterooctadecamer	-	figure legend:5B|comment:Fibromodulin bound to the head regions of C1q.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/18	2020/12/29	-	rogid:S52O/y3SsP4GnuqitcE1ro9C7q89913	-	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
matrixdb:MULT_82_human	uniprotkb:P21793	intact:EBI-6264901|reactome:R-HSA-173579|wwpdb:1PK6|wwpdb:2wnv|wwpdb:2jg8|wwpdb:2jg9|wwpdb:2wnu|reactome:R-HSA-173588	intact:EBI-26573687|ensembl:ENSBTAP00000004562|uniprotkb:Q3MHN1|uniprotkb:Q5U7W0|uniprotkb:Q861V7|uniprotkb:Q862D9|uniprotkb:Q862E8|uniprotkb:Q862L4|uniprotkb:Q862R5	psi-mi:c1q_human(display_short)|psi-mi:MULT_82_human(display_long)|intact:Complement component C1q complex(complex recommended name)|intact:C1q(complex synonym)|intact:Complement 1q(complex synonym)|intact:C1QA-C1QB-C1QC complex(complex synonym)|intact:"6xC1QA:6xC1QB:6xC1QC"(complex systematic name)	psi-mi:pgs2_bovin(display_long)|uniprotkb:Bone proteoglycan II(gene name synonym)|uniprotkb:PG-S2(gene name synonym)|uniprotkb:DCN(gene name)|psi-mi:DCN(display_short)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Skliris et al. (2011)	pubmed:21268013|imex:IM-28597	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26573759|imex:IM-28597-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:0326"(protein)	go:"GO:0005509"(calcium ion binding)|go:"GO:0019865"(immunoglobulin binding)|efo:"MONDO:0013343"(see-also)|pubmed:28601358(see-also)|pubmed:22536204(see-also)|intact:EBI-6264878(exp-evidence)|evidence ontology:"ECO:0000353"|complex portal:CPX-1919(complex-primary)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0005576"(extracellular region)|pubmed:20548024(see-also)|pubmed:29449492(see-also)|pubmed:18250442(see-also)|go:"GO:0062167"(complement component C1q complex)|pubmed:31165008(see-also)|pubmed:27914690(see-also)|pubmed:26489954(see-also)	ensembl:ENSBTAG00000003505(gene)|ensembl:ENSBTAT00000004562(transcript)|go:"GO:0005518"(collagen binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005615"(extracellular space)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019800"(peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan)|go:"GO:0030021"(extracellular matrix structural constituent conferring compression resistance)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0098633"(collagen fibril binding)|go:"GO:1900747"(negative regulation of vascular endothelial growth factor signaling pathway)|go:"GO:1904027"(negative regulation of collagen fibril organization)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR016352(Small leucine-rich proteoglycan, class I, decorin/asporin/byglycan)|interpro:IPR028549|interpro:IPR032675|rcsb pdb:1XCD|rcsb pdb:1XEC|rcsb pdb:1XKU|reactome:R-BTA-1474228|reactome:R-BTA-1971475|reactome:R-BTA-2022870|reactome:R-BTA-2022923|reactome:R-BTA-2024101|reactome:R-BTA-3000178|refseq:NP_776331.2|refseq:XP_005206096.1	-	disease:"Complement component C1q deficiency (C1QD) [MONDO:0013343]: a disorder caused by impaired activation of the complement classical pathway. It generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis."|complex-properties:The complex comprises of six heterotrimeric collagen-like triple helices, formed from triplets of the A, B, and C chains, that associate in their N-terminal half to form a stalk, then diverge to form individual stems, each terminating in a C-terminal globular domain. Each of the six heterotrimeric globular heads or domains is made up of the globular domains from one A, one B, and one C chain, each of which in turn has its own ligand specificity. The six collagen-like stalks appear to be fibril-like and exist in the central region. The collagen-like region and the globular heads can independently interact with a multiplicity of biological structures including pathogen-associated and cell associated molecules, also each of the individual globular head domains is capable of independently interacting with specific ligands. Chains A and B are disulfide-linked whilst the C chain forms a disulfide bond with the C chain of the next strand.     Molecular weight 460 kDa.|curated-complex:"Recognition unit of the classical pathway of complement which associates with the Ca2+ - dependent C1r(2)-C1s(2) tetramer to form C1 (CPX-1920), the first component of the classical complement system. The complex's role in C1 is the recognition of immune complexes, or other molecules, which trigger the classical pathway of the complement system. Independent of complement activation C1q appears to have additional roles in homeostasis and cellular development, superoxide (O2-) production by neutrophils, blood coagulation and neurological synapse pruning."|complex-assembly:Heterooctadecamer	-	figure legend:5C|antagonist:Increasing ionic strength; an above physiological concentration of sodium choloride.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/18	2020/12/29	-	rogid:S6JEGFhRFAh8JgAqovY8LajkO9s9913	-	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:18296"	uniprotkb:P10124	intact:EBI-26573878|chebi:"CHEBI:3675"|chebi:"CHEBI:23223"|chebi:"CHEBI:13991"	intact:EBI-744915|uniprotkb:Q5VW06|uniprotkb:B2R4L7|ensembl:ENSP00000242465	psi-mi:chondroitin 6'-sulfate(display_short)|psi-mi:"CHEBI:18296"(display_long)|intact:chondroitin 6'-sulfate(synonym)|intact:Chondroitin 6'-sulfate(synonym)|intact:"chondroitin 6-(hydrogen sulfate)"(synonym)|intact:Chondroitin 6-sulfate(synonym)|intact:Chondroitin sulfate C(synonym)	psi-mi:srgn_human(display_long)|uniprotkb:Secretory granule proteoglycan core protein(gene name synonym)|uniprotkb:Platelet proteoglycan core protein(gene name synonym)|uniprotkb:SRGN(gene name)|psi-mi:SRGN(display_short)|uniprotkb:PRG(gene name synonym)|uniprotkb:PRG1(gene name synonym)|uniprotkb:Hematopoietic proteoglycan core protein(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Skliris et al. (2011)	pubmed:21268013|imex:IM-28597	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26573863|imex:IM-28597-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_002718.2|go:"GO:0042629"(mast cell granule)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:0140507"(granzyme-mediated programmed cell death signaling pathway)|interpro:IPR007455(Serglycin)|mint:P10124|reactome:R-HSA-114608|ensembl:ENSG00000122862(gene)|ensembl:ENST00000242465(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006915"(apoptotic process)|go:"GO:0016485"(protein processing)|go:"GO:0030141"(secretory granule)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0033363"(secretory granule organization)|go:"GO:0033364"(mast cell secretory granule organization)|go:"GO:0033371"(T cell secretory granule organization)|go:"GO:0033373"(maintenance of protease location in mast cell secretory granule)|go:"GO:0033382"(maintenance of granzyme B location in T cell secretory granule)|refseq:NP_001307982.1|refseq:NP_001307983.1|refseq:XP_016871881.1	-	-	-	figure legend:6B|comment:"It is stated that:- \"Neither CS-4 nor CS-6 had an effect on the  binding between C1q and SG\";however two stars are shown on the image for  15ug/ml CS-6, indicating significance at the p<0.01 level."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/18	2020/12/29	-	rogid:fc8Rv0C285T5/uBa6eAVR4lvW3s9606	-	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P10124	matrixdb:MULT_82_human	intact:EBI-744915|uniprotkb:Q5VW06|uniprotkb:B2R4L7|ensembl:ENSP00000242465	intact:EBI-6264901|reactome:R-HSA-173579|wwpdb:1PK6|wwpdb:2wnv|wwpdb:2jg8|wwpdb:2jg9|wwpdb:2wnu|reactome:R-HSA-173588	psi-mi:srgn_human(display_long)|uniprotkb:Secretory granule proteoglycan core protein(gene name synonym)|uniprotkb:Platelet proteoglycan core protein(gene name synonym)|uniprotkb:SRGN(gene name)|psi-mi:SRGN(display_short)|uniprotkb:PRG(gene name synonym)|uniprotkb:PRG1(gene name synonym)|uniprotkb:Hematopoietic proteoglycan core protein(gene name synonym)	psi-mi:c1q_human(display_short)|psi-mi:MULT_82_human(display_long)|intact:Complement component C1q complex(complex recommended name)|intact:C1q(complex synonym)|intact:Complement 1q(complex synonym)|intact:C1QA-C1QB-C1QC complex(complex synonym)|intact:"6xC1QA:6xC1QB:6xC1QC"(complex systematic name)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Skliris et al. (2011)	pubmed:21268013|imex:IM-28597	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26573863|imex:IM-28597-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:1302"(stable complex)	refseq:NP_002718.2|go:"GO:0042629"(mast cell granule)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:0140507"(granzyme-mediated programmed cell death signaling pathway)|interpro:IPR007455(Serglycin)|mint:P10124|reactome:R-HSA-114608|ensembl:ENSG00000122862(gene)|ensembl:ENST00000242465(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006915"(apoptotic process)|go:"GO:0016485"(protein processing)|go:"GO:0030141"(secretory granule)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0033363"(secretory granule organization)|go:"GO:0033364"(mast cell secretory granule organization)|go:"GO:0033371"(T cell secretory granule organization)|go:"GO:0033373"(maintenance of protease location in mast cell secretory granule)|go:"GO:0033382"(maintenance of granzyme B location in T cell secretory granule)|refseq:NP_001307982.1|refseq:NP_001307983.1|refseq:XP_016871881.1	go:"GO:0005509"(calcium ion binding)|go:"GO:0019865"(immunoglobulin binding)|efo:"MONDO:0013343"(see-also)|pubmed:28601358(see-also)|pubmed:22536204(see-also)|intact:EBI-6264878(exp-evidence)|evidence ontology:"ECO:0000353"|complex portal:CPX-1919(complex-primary)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0005576"(extracellular region)|pubmed:20548024(see-also)|pubmed:29449492(see-also)|pubmed:18250442(see-also)|go:"GO:0062167"(complement component C1q complex)|pubmed:31165008(see-also)|pubmed:27914690(see-also)|pubmed:26489954(see-also)	-	-	disease:"Complement component C1q deficiency (C1QD) [MONDO:0013343]: a disorder caused by impaired activation of the complement classical pathway. It generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis."|complex-properties:The complex comprises of six heterotrimeric collagen-like triple helices, formed from triplets of the A, B, and C chains, that associate in their N-terminal half to form a stalk, then diverge to form individual stems, each terminating in a C-terminal globular domain. Each of the six heterotrimeric globular heads or domains is made up of the globular domains from one A, one B, and one C chain, each of which in turn has its own ligand specificity. The six collagen-like stalks appear to be fibril-like and exist in the central region. The collagen-like region and the globular heads can independently interact with a multiplicity of biological structures including pathogen-associated and cell associated molecules, also each of the individual globular head domains is capable of independently interacting with specific ligands. Chains A and B are disulfide-linked whilst the C chain forms a disulfide bond with the C chain of the next strand.     Molecular weight 460 kDa.|curated-complex:"Recognition unit of the classical pathway of complement which associates with the Ca2+ - dependent C1r(2)-C1s(2) tetramer to form C1 (CPX-1920), the first component of the classical complement system. The complex's role in C1 is the recognition of immune complexes, or other molecules, which trigger the classical pathway of the complement system. Independent of complement activation C1q appears to have additional roles in homeostasis and cellular development, superoxide (O2-) production by neutrophils, blood coagulation and neurological synapse pruning."|complex-assembly:Heterooctadecamer	figure legend:6B|comment:"It is stated that:- \"Neither CS-4 nor CS-6 had an effect on the  binding between C1q and SG\";however two stars are shown on the image for  15ug/ml CS-6, indicating significance at the p<0.01 level."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/18	2020/12/29	rogid:fc8Rv0C285T5/uBa6eAVR4lvW3s9606	-	-	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:167154"	uniprotkb:P10124	intact:EBI-26573903	intact:EBI-744915|uniprotkb:Q5VW06|uniprotkb:B2R4L7|ensembl:ENSP00000242465	psi-mi:"chondroitin-2,6-sulfate (d)"(display_short)|psi-mi:"CHEBI:167154"(display_long)	psi-mi:srgn_human(display_long)|uniprotkb:Secretory granule proteoglycan core protein(gene name synonym)|uniprotkb:Platelet proteoglycan core protein(gene name synonym)|uniprotkb:SRGN(gene name)|psi-mi:SRGN(display_short)|uniprotkb:PRG(gene name synonym)|uniprotkb:PRG1(gene name synonym)|uniprotkb:Hematopoietic proteoglycan core protein(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Skliris et al. (2011)	pubmed:21268013|imex:IM-28597	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26573898|imex:IM-28597-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_002718.2|go:"GO:0042629"(mast cell granule)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:0140507"(granzyme-mediated programmed cell death signaling pathway)|interpro:IPR007455(Serglycin)|mint:P10124|reactome:R-HSA-114608|ensembl:ENSG00000122862(gene)|ensembl:ENST00000242465(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006915"(apoptotic process)|go:"GO:0016485"(protein processing)|go:"GO:0030141"(secretory granule)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0033363"(secretory granule organization)|go:"GO:0033364"(mast cell secretory granule organization)|go:"GO:0033371"(T cell secretory granule organization)|go:"GO:0033373"(maintenance of protease location in mast cell secretory granule)|go:"GO:0033382"(maintenance of granzyme B location in T cell secretory granule)|refseq:NP_001307982.1|refseq:NP_001307983.1|refseq:XP_016871881.1	-	-	-	figure legend:6B|caution:"The methods section describes CS-D as having  \"..sulfate both in the 4 and 6 position of the galactosamine\" and CS-E as \"sulfate in the 2 position of the glucuronate and 6 position of the galactosamine\".  However CS-E is elsewhere (including wiki article on gags, chebi database) described as having sulfated \"carbons 4 and 6 of the GalNAc sugar\" and CS-D as having \"carbon 2 of the glucuronic acid and 6 of the GalNAc sugar\" (wiki article and pmid:22264297).  It would thus appear the methods have the gag's composition listed the \"wrong way round\"."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/18	2020/12/29	-	rogid:fc8Rv0C285T5/uBa6eAVR4lvW3s9606	-	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P10124	matrixdb:MULT_82_human	intact:EBI-744915|uniprotkb:Q5VW06|uniprotkb:B2R4L7|ensembl:ENSP00000242465	intact:EBI-6264901|reactome:R-HSA-173579|wwpdb:1PK6|wwpdb:2wnv|wwpdb:2jg8|wwpdb:2jg9|wwpdb:2wnu|reactome:R-HSA-173588	psi-mi:srgn_human(display_long)|uniprotkb:Secretory granule proteoglycan core protein(gene name synonym)|uniprotkb:Platelet proteoglycan core protein(gene name synonym)|uniprotkb:SRGN(gene name)|psi-mi:SRGN(display_short)|uniprotkb:PRG(gene name synonym)|uniprotkb:PRG1(gene name synonym)|uniprotkb:Hematopoietic proteoglycan core protein(gene name synonym)	psi-mi:c1q_human(display_short)|psi-mi:MULT_82_human(display_long)|intact:Complement component C1q complex(complex recommended name)|intact:C1q(complex synonym)|intact:Complement 1q(complex synonym)|intact:C1QA-C1QB-C1QC complex(complex synonym)|intact:"6xC1QA:6xC1QB:6xC1QC"(complex systematic name)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Skliris et al. (2011)	pubmed:21268013|imex:IM-28597	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26573898|imex:IM-28597-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:1302"(stable complex)	refseq:NP_002718.2|go:"GO:0042629"(mast cell granule)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:0140507"(granzyme-mediated programmed cell death signaling pathway)|interpro:IPR007455(Serglycin)|mint:P10124|reactome:R-HSA-114608|ensembl:ENSG00000122862(gene)|ensembl:ENST00000242465(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006915"(apoptotic process)|go:"GO:0016485"(protein processing)|go:"GO:0030141"(secretory granule)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0033363"(secretory granule organization)|go:"GO:0033364"(mast cell secretory granule organization)|go:"GO:0033371"(T cell secretory granule organization)|go:"GO:0033373"(maintenance of protease location in mast cell secretory granule)|go:"GO:0033382"(maintenance of granzyme B location in T cell secretory granule)|refseq:NP_001307982.1|refseq:NP_001307983.1|refseq:XP_016871881.1	go:"GO:0005509"(calcium ion binding)|go:"GO:0019865"(immunoglobulin binding)|efo:"MONDO:0013343"(see-also)|pubmed:28601358(see-also)|pubmed:22536204(see-also)|intact:EBI-6264878(exp-evidence)|evidence ontology:"ECO:0000353"|complex portal:CPX-1919(complex-primary)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0005576"(extracellular region)|pubmed:20548024(see-also)|pubmed:29449492(see-also)|pubmed:18250442(see-also)|go:"GO:0062167"(complement component C1q complex)|pubmed:31165008(see-also)|pubmed:27914690(see-also)|pubmed:26489954(see-also)	-	-	disease:"Complement component C1q deficiency (C1QD) [MONDO:0013343]: a disorder caused by impaired activation of the complement classical pathway. It generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis."|complex-properties:The complex comprises of six heterotrimeric collagen-like triple helices, formed from triplets of the A, B, and C chains, that associate in their N-terminal half to form a stalk, then diverge to form individual stems, each terminating in a C-terminal globular domain. Each of the six heterotrimeric globular heads or domains is made up of the globular domains from one A, one B, and one C chain, each of which in turn has its own ligand specificity. The six collagen-like stalks appear to be fibril-like and exist in the central region. The collagen-like region and the globular heads can independently interact with a multiplicity of biological structures including pathogen-associated and cell associated molecules, also each of the individual globular head domains is capable of independently interacting with specific ligands. Chains A and B are disulfide-linked whilst the C chain forms a disulfide bond with the C chain of the next strand.     Molecular weight 460 kDa.|curated-complex:"Recognition unit of the classical pathway of complement which associates with the Ca2+ - dependent C1r(2)-C1s(2) tetramer to form C1 (CPX-1920), the first component of the classical complement system. The complex's role in C1 is the recognition of immune complexes, or other molecules, which trigger the classical pathway of the complement system. Independent of complement activation C1q appears to have additional roles in homeostasis and cellular development, superoxide (O2-) production by neutrophils, blood coagulation and neurological synapse pruning."|complex-assembly:Heterooctadecamer	figure legend:6B|caution:"The methods section describes CS-D as having  \"..sulfate both in the 4 and 6 position of the galactosamine\" and CS-E as \"sulfate in the 2 position of the glucuronate and 6 position of the galactosamine\".  However CS-E is elsewhere (including wiki article on gags, chebi database) described as having sulfated \"carbons 4 and 6 of the GalNAc sugar\" and CS-D as having \"carbon 2 of the glucuronic acid and 6 of the GalNAc sugar\" (wiki article and pmid:22264297).  It would thus appear the methods have the gag's composition listed the \"wrong way round\"."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/18	2020/12/29	rogid:fc8Rv0C285T5/uBa6eAVR4lvW3s9606	-	-	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:52562"	uniprotkb:P10124	intact:EBI-6895140	intact:EBI-744915|uniprotkb:Q5VW06|uniprotkb:B2R4L7|ensembl:ENSP00000242465	psi-mi:chondroitin sulfate e(display_short)|psi-mi:"CHEBI:52562"(display_long)	psi-mi:srgn_human(display_long)|uniprotkb:Secretory granule proteoglycan core protein(gene name synonym)|uniprotkb:Platelet proteoglycan core protein(gene name synonym)|uniprotkb:SRGN(gene name)|psi-mi:SRGN(display_short)|uniprotkb:PRG(gene name synonym)|uniprotkb:PRG1(gene name synonym)|uniprotkb:Hematopoietic proteoglycan core protein(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Skliris et al. (2011)	pubmed:21268013|imex:IM-28597	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26573905|imex:IM-28597-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_002718.2|go:"GO:0042629"(mast cell granule)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:0140507"(granzyme-mediated programmed cell death signaling pathway)|interpro:IPR007455(Serglycin)|mint:P10124|reactome:R-HSA-114608|ensembl:ENSG00000122862(gene)|ensembl:ENST00000242465(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006915"(apoptotic process)|go:"GO:0016485"(protein processing)|go:"GO:0030141"(secretory granule)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0033363"(secretory granule organization)|go:"GO:0033364"(mast cell secretory granule organization)|go:"GO:0033371"(T cell secretory granule organization)|go:"GO:0033373"(maintenance of protease location in mast cell secretory granule)|go:"GO:0033382"(maintenance of granzyme B location in T cell secretory granule)|refseq:NP_001307982.1|refseq:NP_001307983.1|refseq:XP_016871881.1	-	-	-	figure legend:6B|caution:"The methods section describes CS-D as having  \"..sulfate both in the 4 and 6 position of the galactosamine\" and CS-E as \"sulfate in the 2 position of the glucuronate and 6 position of the galactosamine\".  However CS-E is elsewhere (including wiki article on gags, chebi database) described as having sulfated \"carbons 4 and 6 of the GalNAc sugar\" and CS-D as having \"carbon 2 of the glucuronic acid and 6 of the GalNAc sugar\" (wiki article and pmid:22264297).  It would thus appear the methods have the gag's composition listed the \"wrong way round\"."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/18	2020/12/29	-	rogid:fc8Rv0C285T5/uBa6eAVR4lvW3s9606	-	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P10124	matrixdb:MULT_82_human	intact:EBI-744915|uniprotkb:Q5VW06|uniprotkb:B2R4L7|ensembl:ENSP00000242465	intact:EBI-6264901|reactome:R-HSA-173579|wwpdb:1PK6|wwpdb:2wnv|wwpdb:2jg8|wwpdb:2jg9|wwpdb:2wnu|reactome:R-HSA-173588	psi-mi:srgn_human(display_long)|uniprotkb:Secretory granule proteoglycan core protein(gene name synonym)|uniprotkb:Platelet proteoglycan core protein(gene name synonym)|uniprotkb:SRGN(gene name)|psi-mi:SRGN(display_short)|uniprotkb:PRG(gene name synonym)|uniprotkb:PRG1(gene name synonym)|uniprotkb:Hematopoietic proteoglycan core protein(gene name synonym)	psi-mi:c1q_human(display_short)|psi-mi:MULT_82_human(display_long)|intact:Complement component C1q complex(complex recommended name)|intact:C1q(complex synonym)|intact:Complement 1q(complex synonym)|intact:C1QA-C1QB-C1QC complex(complex synonym)|intact:"6xC1QA:6xC1QB:6xC1QC"(complex systematic name)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Skliris et al. (2011)	pubmed:21268013|imex:IM-28597	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26573905|imex:IM-28597-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:1302"(stable complex)	refseq:NP_002718.2|go:"GO:0042629"(mast cell granule)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:0140507"(granzyme-mediated programmed cell death signaling pathway)|interpro:IPR007455(Serglycin)|mint:P10124|reactome:R-HSA-114608|ensembl:ENSG00000122862(gene)|ensembl:ENST00000242465(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006915"(apoptotic process)|go:"GO:0016485"(protein processing)|go:"GO:0030141"(secretory granule)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0033363"(secretory granule organization)|go:"GO:0033364"(mast cell secretory granule organization)|go:"GO:0033371"(T cell secretory granule organization)|go:"GO:0033373"(maintenance of protease location in mast cell secretory granule)|go:"GO:0033382"(maintenance of granzyme B location in T cell secretory granule)|refseq:NP_001307982.1|refseq:NP_001307983.1|refseq:XP_016871881.1	go:"GO:0005509"(calcium ion binding)|go:"GO:0019865"(immunoglobulin binding)|efo:"MONDO:0013343"(see-also)|pubmed:28601358(see-also)|pubmed:22536204(see-also)|intact:EBI-6264878(exp-evidence)|evidence ontology:"ECO:0000353"|complex portal:CPX-1919(complex-primary)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0005576"(extracellular region)|pubmed:20548024(see-also)|pubmed:29449492(see-also)|pubmed:18250442(see-also)|go:"GO:0062167"(complement component C1q complex)|pubmed:31165008(see-also)|pubmed:27914690(see-also)|pubmed:26489954(see-also)	-	-	disease:"Complement component C1q deficiency (C1QD) [MONDO:0013343]: a disorder caused by impaired activation of the complement classical pathway. It generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis."|complex-properties:The complex comprises of six heterotrimeric collagen-like triple helices, formed from triplets of the A, B, and C chains, that associate in their N-terminal half to form a stalk, then diverge to form individual stems, each terminating in a C-terminal globular domain. Each of the six heterotrimeric globular heads or domains is made up of the globular domains from one A, one B, and one C chain, each of which in turn has its own ligand specificity. The six collagen-like stalks appear to be fibril-like and exist in the central region. The collagen-like region and the globular heads can independently interact with a multiplicity of biological structures including pathogen-associated and cell associated molecules, also each of the individual globular head domains is capable of independently interacting with specific ligands. Chains A and B are disulfide-linked whilst the C chain forms a disulfide bond with the C chain of the next strand.     Molecular weight 460 kDa.|curated-complex:"Recognition unit of the classical pathway of complement which associates with the Ca2+ - dependent C1r(2)-C1s(2) tetramer to form C1 (CPX-1920), the first component of the classical complement system. The complex's role in C1 is the recognition of immune complexes, or other molecules, which trigger the classical pathway of the complement system. Independent of complement activation C1q appears to have additional roles in homeostasis and cellular development, superoxide (O2-) production by neutrophils, blood coagulation and neurological synapse pruning."|complex-assembly:Heterooctadecamer	figure legend:6B|caution:"The methods section describes CS-D as having  \"..sulfate both in the 4 and 6 position of the galactosamine\" and CS-E as \"sulfate in the 2 position of the glucuronate and 6 position of the galactosamine\".  However CS-E is elsewhere (including wiki article on gags, chebi database) described as having sulfated \"carbons 4 and 6 of the GalNAc sugar\" and CS-D as having \"carbon 2 of the glucuronic acid and 6 of the GalNAc sugar\" (wiki article and pmid:22264297).  It would thus appear the methods have the gag's composition listed the \"wrong way round\"."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/18	2020/12/29	rogid:fc8Rv0C285T5/uBa6eAVR4lvW3s9606	-	-	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:28304"	uniprotkb:P10124	intact:EBI-1379423	intact:EBI-744915|uniprotkb:Q5VW06|uniprotkb:B2R4L7|ensembl:ENSP00000242465	psi-mi:heparin(display_short)|psi-mi:"CHEBI:28304"(display_long)	psi-mi:srgn_human(display_long)|uniprotkb:Secretory granule proteoglycan core protein(gene name synonym)|uniprotkb:Platelet proteoglycan core protein(gene name synonym)|uniprotkb:SRGN(gene name)|psi-mi:SRGN(display_short)|uniprotkb:PRG(gene name synonym)|uniprotkb:PRG1(gene name synonym)|uniprotkb:Hematopoietic proteoglycan core protein(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Skliris et al. (2011)	pubmed:21268013|imex:IM-28597	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26574090|imex:IM-28597-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_002718.2|go:"GO:0042629"(mast cell granule)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:0140507"(granzyme-mediated programmed cell death signaling pathway)|interpro:IPR007455(Serglycin)|mint:P10124|reactome:R-HSA-114608|ensembl:ENSG00000122862(gene)|ensembl:ENST00000242465(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006915"(apoptotic process)|go:"GO:0016485"(protein processing)|go:"GO:0030141"(secretory granule)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0033363"(secretory granule organization)|go:"GO:0033364"(mast cell secretory granule organization)|go:"GO:0033371"(T cell secretory granule organization)|go:"GO:0033373"(maintenance of protease location in mast cell secretory granule)|go:"GO:0033382"(maintenance of granzyme B location in T cell secretory granule)|refseq:NP_001307982.1|refseq:NP_001307983.1|refseq:XP_016871881.1	-	-	-	figure legend:6B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/18	2020/12/29	-	rogid:fc8Rv0C285T5/uBa6eAVR4lvW3s9606	-	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P10124	matrixdb:MULT_82_human	intact:EBI-744915|uniprotkb:Q5VW06|uniprotkb:B2R4L7|ensembl:ENSP00000242465	intact:EBI-6264901|reactome:R-HSA-173579|wwpdb:1PK6|wwpdb:2wnv|wwpdb:2jg8|wwpdb:2jg9|wwpdb:2wnu|reactome:R-HSA-173588	psi-mi:srgn_human(display_long)|uniprotkb:Secretory granule proteoglycan core protein(gene name synonym)|uniprotkb:Platelet proteoglycan core protein(gene name synonym)|uniprotkb:SRGN(gene name)|psi-mi:SRGN(display_short)|uniprotkb:PRG(gene name synonym)|uniprotkb:PRG1(gene name synonym)|uniprotkb:Hematopoietic proteoglycan core protein(gene name synonym)	psi-mi:c1q_human(display_short)|psi-mi:MULT_82_human(display_long)|intact:Complement component C1q complex(complex recommended name)|intact:C1q(complex synonym)|intact:Complement 1q(complex synonym)|intact:C1QA-C1QB-C1QC complex(complex synonym)|intact:"6xC1QA:6xC1QB:6xC1QC"(complex systematic name)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Skliris et al. (2011)	pubmed:21268013|imex:IM-28597	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26574090|imex:IM-28597-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:1302"(stable complex)	refseq:NP_002718.2|go:"GO:0042629"(mast cell granule)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:0140507"(granzyme-mediated programmed cell death signaling pathway)|interpro:IPR007455(Serglycin)|mint:P10124|reactome:R-HSA-114608|ensembl:ENSG00000122862(gene)|ensembl:ENST00000242465(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006915"(apoptotic process)|go:"GO:0016485"(protein processing)|go:"GO:0030141"(secretory granule)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0033363"(secretory granule organization)|go:"GO:0033364"(mast cell secretory granule organization)|go:"GO:0033371"(T cell secretory granule organization)|go:"GO:0033373"(maintenance of protease location in mast cell secretory granule)|go:"GO:0033382"(maintenance of granzyme B location in T cell secretory granule)|refseq:NP_001307982.1|refseq:NP_001307983.1|refseq:XP_016871881.1	go:"GO:0005509"(calcium ion binding)|go:"GO:0019865"(immunoglobulin binding)|efo:"MONDO:0013343"(see-also)|pubmed:28601358(see-also)|pubmed:22536204(see-also)|intact:EBI-6264878(exp-evidence)|evidence ontology:"ECO:0000353"|complex portal:CPX-1919(complex-primary)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0005576"(extracellular region)|pubmed:20548024(see-also)|pubmed:29449492(see-also)|pubmed:18250442(see-also)|go:"GO:0062167"(complement component C1q complex)|pubmed:31165008(see-also)|pubmed:27914690(see-also)|pubmed:26489954(see-also)	-	-	disease:"Complement component C1q deficiency (C1QD) [MONDO:0013343]: a disorder caused by impaired activation of the complement classical pathway. It generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis."|complex-properties:The complex comprises of six heterotrimeric collagen-like triple helices, formed from triplets of the A, B, and C chains, that associate in their N-terminal half to form a stalk, then diverge to form individual stems, each terminating in a C-terminal globular domain. Each of the six heterotrimeric globular heads or domains is made up of the globular domains from one A, one B, and one C chain, each of which in turn has its own ligand specificity. The six collagen-like stalks appear to be fibril-like and exist in the central region. The collagen-like region and the globular heads can independently interact with a multiplicity of biological structures including pathogen-associated and cell associated molecules, also each of the individual globular head domains is capable of independently interacting with specific ligands. Chains A and B are disulfide-linked whilst the C chain forms a disulfide bond with the C chain of the next strand.     Molecular weight 460 kDa.|curated-complex:"Recognition unit of the classical pathway of complement which associates with the Ca2+ - dependent C1r(2)-C1s(2) tetramer to form C1 (CPX-1920), the first component of the classical complement system. The complex's role in C1 is the recognition of immune complexes, or other molecules, which trigger the classical pathway of the complement system. Independent of complement activation C1q appears to have additional roles in homeostasis and cellular development, superoxide (O2-) production by neutrophils, blood coagulation and neurological synapse pruning."|complex-assembly:Heterooctadecamer	figure legend:6B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/18	2020/12/29	rogid:fc8Rv0C285T5/uBa6eAVR4lvW3s9606	-	-	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:37397"	uniprotkb:P10124	intact:EBI-9673920|chebi:"CHEBI:23224"|chebi:"CHEBI:3676"	intact:EBI-744915|uniprotkb:Q5VW06|uniprotkb:B2R4L7|ensembl:ENSP00000242465	psi-mi:chondroitin sulfate-1(display_short)|psi-mi:"CHEBI:37397"(display_long)|intact:chondroitin polysulfate(synonym)|intact:Chondroitin sulfate(synonym)|intact:chondroitin sulfates(synonym)|intact:chondroitin sulfuric acid(synonym)|intact:chondroitin sulphate(synonym)|intact:Chondroitinsulfat(synonym)	psi-mi:srgn_human(display_long)|uniprotkb:Secretory granule proteoglycan core protein(gene name synonym)|uniprotkb:Platelet proteoglycan core protein(gene name synonym)|uniprotkb:SRGN(gene name)|psi-mi:SRGN(display_short)|uniprotkb:PRG(gene name synonym)|uniprotkb:PRG1(gene name synonym)|uniprotkb:Hematopoietic proteoglycan core protein(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Skliris et al. (2011)	pubmed:21268013|imex:IM-28597	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26574096|imex:IM-28597-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_002718.2|go:"GO:0042629"(mast cell granule)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:0140507"(granzyme-mediated programmed cell death signaling pathway)|interpro:IPR007455(Serglycin)|mint:P10124|reactome:R-HSA-114608|ensembl:ENSG00000122862(gene)|ensembl:ENST00000242465(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006915"(apoptotic process)|go:"GO:0016485"(protein processing)|go:"GO:0030141"(secretory granule)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0033363"(secretory granule organization)|go:"GO:0033364"(mast cell secretory granule organization)|go:"GO:0033371"(T cell secretory granule organization)|go:"GO:0033373"(maintenance of protease location in mast cell secretory granule)|go:"GO:0033382"(maintenance of granzyme B location in T cell secretory granule)|refseq:NP_001307982.1|refseq:NP_001307983.1|refseq:XP_016871881.1	-	-	-	figure legend:6B|comment:"Serglycin-derived Chondroitin Sulfate is stated to be constituted by  \"4-sulfated disaccharides (92.5%), low amounts of six-sulfated disac-  charides (4.5%) and only trace amounts of non-sulfated (1.5%) and (4,6)-disulfated units (1.5%)\"."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/18	2020/12/29	-	rogid:fc8Rv0C285T5/uBa6eAVR4lvW3s9606	-	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P10124	matrixdb:MULT_82_human	intact:EBI-744915|uniprotkb:Q5VW06|uniprotkb:B2R4L7|ensembl:ENSP00000242465	intact:EBI-6264901|reactome:R-HSA-173579|wwpdb:1PK6|wwpdb:2wnv|wwpdb:2jg8|wwpdb:2jg9|wwpdb:2wnu|reactome:R-HSA-173588	psi-mi:srgn_human(display_long)|uniprotkb:Secretory granule proteoglycan core protein(gene name synonym)|uniprotkb:Platelet proteoglycan core protein(gene name synonym)|uniprotkb:SRGN(gene name)|psi-mi:SRGN(display_short)|uniprotkb:PRG(gene name synonym)|uniprotkb:PRG1(gene name synonym)|uniprotkb:Hematopoietic proteoglycan core protein(gene name synonym)	psi-mi:c1q_human(display_short)|psi-mi:MULT_82_human(display_long)|intact:Complement component C1q complex(complex recommended name)|intact:C1q(complex synonym)|intact:Complement 1q(complex synonym)|intact:C1QA-C1QB-C1QC complex(complex synonym)|intact:"6xC1QA:6xC1QB:6xC1QC"(complex systematic name)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Skliris et al. (2011)	pubmed:21268013|imex:IM-28597	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26574096|imex:IM-28597-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:1302"(stable complex)	refseq:NP_002718.2|go:"GO:0042629"(mast cell granule)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:0140507"(granzyme-mediated programmed cell death signaling pathway)|interpro:IPR007455(Serglycin)|mint:P10124|reactome:R-HSA-114608|ensembl:ENSG00000122862(gene)|ensembl:ENST00000242465(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006915"(apoptotic process)|go:"GO:0016485"(protein processing)|go:"GO:0030141"(secretory granule)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0033363"(secretory granule organization)|go:"GO:0033364"(mast cell secretory granule organization)|go:"GO:0033371"(T cell secretory granule organization)|go:"GO:0033373"(maintenance of protease location in mast cell secretory granule)|go:"GO:0033382"(maintenance of granzyme B location in T cell secretory granule)|refseq:NP_001307982.1|refseq:NP_001307983.1|refseq:XP_016871881.1	go:"GO:0005509"(calcium ion binding)|go:"GO:0019865"(immunoglobulin binding)|efo:"MONDO:0013343"(see-also)|pubmed:28601358(see-also)|pubmed:22536204(see-also)|intact:EBI-6264878(exp-evidence)|evidence ontology:"ECO:0000353"|complex portal:CPX-1919(complex-primary)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0005576"(extracellular region)|pubmed:20548024(see-also)|pubmed:29449492(see-also)|pubmed:18250442(see-also)|go:"GO:0062167"(complement component C1q complex)|pubmed:31165008(see-also)|pubmed:27914690(see-also)|pubmed:26489954(see-also)	-	-	disease:"Complement component C1q deficiency (C1QD) [MONDO:0013343]: a disorder caused by impaired activation of the complement classical pathway. It generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis."|complex-properties:The complex comprises of six heterotrimeric collagen-like triple helices, formed from triplets of the A, B, and C chains, that associate in their N-terminal half to form a stalk, then diverge to form individual stems, each terminating in a C-terminal globular domain. Each of the six heterotrimeric globular heads or domains is made up of the globular domains from one A, one B, and one C chain, each of which in turn has its own ligand specificity. The six collagen-like stalks appear to be fibril-like and exist in the central region. The collagen-like region and the globular heads can independently interact with a multiplicity of biological structures including pathogen-associated and cell associated molecules, also each of the individual globular head domains is capable of independently interacting with specific ligands. Chains A and B are disulfide-linked whilst the C chain forms a disulfide bond with the C chain of the next strand.     Molecular weight 460 kDa.|curated-complex:"Recognition unit of the classical pathway of complement which associates with the Ca2+ - dependent C1r(2)-C1s(2) tetramer to form C1 (CPX-1920), the first component of the classical complement system. The complex's role in C1 is the recognition of immune complexes, or other molecules, which trigger the classical pathway of the complement system. Independent of complement activation C1q appears to have additional roles in homeostasis and cellular development, superoxide (O2-) production by neutrophils, blood coagulation and neurological synapse pruning."|complex-assembly:Heterooctadecamer	figure legend:6B|comment:"Serglycin-derived Chondroitin Sulfate is stated to be constituted by  \"4-sulfated disaccharides (92.5%), low amounts of six-sulfated disac-  charides (4.5%) and only trace amounts of non-sulfated (1.5%) and (4,6)-disulfated units (1.5%)\"."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/18	2020/12/29	rogid:fc8Rv0C285T5/uBa6eAVR4lvW3s9606	-	-	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:60924"	uniprotkb:P10124	intact:EBI-20725289	intact:EBI-744915|uniprotkb:Q5VW06|uniprotkb:B2R4L7|ensembl:ENSP00000242465	psi-mi:keratan sulfate(display_short)|psi-mi:"CHEBI:60924"(display_long)|intact:keratan sulfates(synonym)|intact:keratosulfate(synonym)	psi-mi:srgn_human(display_long)|uniprotkb:Secretory granule proteoglycan core protein(gene name synonym)|uniprotkb:Platelet proteoglycan core protein(gene name synonym)|uniprotkb:SRGN(gene name)|psi-mi:SRGN(display_short)|uniprotkb:PRG(gene name synonym)|uniprotkb:PRG1(gene name synonym)|uniprotkb:Hematopoietic proteoglycan core protein(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Skliris et al. (2011)	pubmed:21268013|imex:IM-28597	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26574110|imex:IM-28597-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0840"(stimulator)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_002718.2|go:"GO:0042629"(mast cell granule)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:0140507"(granzyme-mediated programmed cell death signaling pathway)|interpro:IPR007455(Serglycin)|mint:P10124|reactome:R-HSA-114608|ensembl:ENSG00000122862(gene)|ensembl:ENST00000242465(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006915"(apoptotic process)|go:"GO:0016485"(protein processing)|go:"GO:0030141"(secretory granule)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0033363"(secretory granule organization)|go:"GO:0033364"(mast cell secretory granule organization)|go:"GO:0033371"(T cell secretory granule organization)|go:"GO:0033373"(maintenance of protease location in mast cell secretory granule)|go:"GO:0033382"(maintenance of granzyme B location in T cell secretory granule)|refseq:NP_001307982.1|refseq:NP_001307983.1|refseq:XP_016871881.1	-	-	-	figure legend:6B|comment:"KS‐2 (skeletal KS) was used. [KSII is O-linked to specific serine or threonine amino acids via N-acetylgalactosamine]."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/18	2020/12/29	-	rogid:fc8Rv0C285T5/uBa6eAVR4lvW3s9606	-	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P10124	matrixdb:MULT_82_human	intact:EBI-744915|uniprotkb:Q5VW06|uniprotkb:B2R4L7|ensembl:ENSP00000242465	intact:EBI-6264901|reactome:R-HSA-173579|wwpdb:1PK6|wwpdb:2wnv|wwpdb:2jg8|wwpdb:2jg9|wwpdb:2wnu|reactome:R-HSA-173588	psi-mi:srgn_human(display_long)|uniprotkb:Secretory granule proteoglycan core protein(gene name synonym)|uniprotkb:Platelet proteoglycan core protein(gene name synonym)|uniprotkb:SRGN(gene name)|psi-mi:SRGN(display_short)|uniprotkb:PRG(gene name synonym)|uniprotkb:PRG1(gene name synonym)|uniprotkb:Hematopoietic proteoglycan core protein(gene name synonym)	psi-mi:c1q_human(display_short)|psi-mi:MULT_82_human(display_long)|intact:Complement component C1q complex(complex recommended name)|intact:C1q(complex synonym)|intact:Complement 1q(complex synonym)|intact:C1QA-C1QB-C1QC complex(complex synonym)|intact:"6xC1QA:6xC1QB:6xC1QC"(complex systematic name)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Skliris et al. (2011)	pubmed:21268013|imex:IM-28597	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26574110|imex:IM-28597-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:1302"(stable complex)	refseq:NP_002718.2|go:"GO:0042629"(mast cell granule)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:0140507"(granzyme-mediated programmed cell death signaling pathway)|interpro:IPR007455(Serglycin)|mint:P10124|reactome:R-HSA-114608|ensembl:ENSG00000122862(gene)|ensembl:ENST00000242465(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006915"(apoptotic process)|go:"GO:0016485"(protein processing)|go:"GO:0030141"(secretory granule)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0033363"(secretory granule organization)|go:"GO:0033364"(mast cell secretory granule organization)|go:"GO:0033371"(T cell secretory granule organization)|go:"GO:0033373"(maintenance of protease location in mast cell secretory granule)|go:"GO:0033382"(maintenance of granzyme B location in T cell secretory granule)|refseq:NP_001307982.1|refseq:NP_001307983.1|refseq:XP_016871881.1	go:"GO:0005509"(calcium ion binding)|go:"GO:0019865"(immunoglobulin binding)|efo:"MONDO:0013343"(see-also)|pubmed:28601358(see-also)|pubmed:22536204(see-also)|intact:EBI-6264878(exp-evidence)|evidence ontology:"ECO:0000353"|complex portal:CPX-1919(complex-primary)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0005576"(extracellular region)|pubmed:20548024(see-also)|pubmed:29449492(see-also)|pubmed:18250442(see-also)|go:"GO:0062167"(complement component C1q complex)|pubmed:31165008(see-also)|pubmed:27914690(see-also)|pubmed:26489954(see-also)	-	-	disease:"Complement component C1q deficiency (C1QD) [MONDO:0013343]: a disorder caused by impaired activation of the complement classical pathway. It generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis."|complex-properties:The complex comprises of six heterotrimeric collagen-like triple helices, formed from triplets of the A, B, and C chains, that associate in their N-terminal half to form a stalk, then diverge to form individual stems, each terminating in a C-terminal globular domain. Each of the six heterotrimeric globular heads or domains is made up of the globular domains from one A, one B, and one C chain, each of which in turn has its own ligand specificity. The six collagen-like stalks appear to be fibril-like and exist in the central region. The collagen-like region and the globular heads can independently interact with a multiplicity of biological structures including pathogen-associated and cell associated molecules, also each of the individual globular head domains is capable of independently interacting with specific ligands. Chains A and B are disulfide-linked whilst the C chain forms a disulfide bond with the C chain of the next strand.     Molecular weight 460 kDa.|curated-complex:"Recognition unit of the classical pathway of complement which associates with the Ca2+ - dependent C1r(2)-C1s(2) tetramer to form C1 (CPX-1920), the first component of the classical complement system. The complex's role in C1 is the recognition of immune complexes, or other molecules, which trigger the classical pathway of the complement system. Independent of complement activation C1q appears to have additional roles in homeostasis and cellular development, superoxide (O2-) production by neutrophils, blood coagulation and neurological synapse pruning."|complex-assembly:Heterooctadecamer	figure legend:6B|comment:"KS‐2 (skeletal KS) was used. [KSII is O-linked to specific serine or threonine amino acids via N-acetylgalactosamine]."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/18	2020/12/29	rogid:fc8Rv0C285T5/uBa6eAVR4lvW3s9606	-	-	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:52562"	uniprotkb:P10124	intact:EBI-6895140	intact:EBI-744915|uniprotkb:Q5VW06|uniprotkb:B2R4L7|ensembl:ENSP00000242465	psi-mi:chondroitin sulfate e(display_short)|psi-mi:"CHEBI:52562"(display_long)	psi-mi:srgn_human(display_long)|uniprotkb:Secretory granule proteoglycan core protein(gene name synonym)|uniprotkb:Platelet proteoglycan core protein(gene name synonym)|uniprotkb:SRGN(gene name)|psi-mi:SRGN(display_short)|uniprotkb:PRG(gene name synonym)|uniprotkb:PRG1(gene name synonym)|uniprotkb:Hematopoietic proteoglycan core protein(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Skliris et al. (2011)	pubmed:21268013|imex:IM-28597	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26574117|imex:IM-28597-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_002718.2|go:"GO:0042629"(mast cell granule)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:0140507"(granzyme-mediated programmed cell death signaling pathway)|interpro:IPR007455(Serglycin)|mint:P10124|reactome:R-HSA-114608|ensembl:ENSG00000122862(gene)|ensembl:ENST00000242465(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006915"(apoptotic process)|go:"GO:0016485"(protein processing)|go:"GO:0030141"(secretory granule)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0033363"(secretory granule organization)|go:"GO:0033364"(mast cell secretory granule organization)|go:"GO:0033371"(T cell secretory granule organization)|go:"GO:0033373"(maintenance of protease location in mast cell secretory granule)|go:"GO:0033382"(maintenance of granzyme B location in T cell secretory granule)|refseq:NP_001307982.1|refseq:NP_001307983.1|refseq:XP_016871881.1	-	-	-	figure legend:6D|caution:"The methods section describes CS-D as having  \"..sulfate both in the 4 and 6 position of the galactosamine\" and CS-E as \"sulfate in the 2 position of the glucuronate and 6 position of the galactosamine\".  However CS-E is elsewhere (including wiki article on gags, chebi database) described as having sulfated \"carbons 4 and 6 of the GalNAc sugar\" and CS-D as having \"carbon 2 of the glucuronic acid and 6 of the GalNAc sugar\" (wiki article and pmid:22264297).  It would thus appear the methods have the gag's composition listed the \"wrong way round\"."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/18	2020/12/29	-	rogid:fc8Rv0C285T5/uBa6eAVR4lvW3s9606	-	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P10124	uniprotkb:P11226	intact:EBI-744915|uniprotkb:Q5VW06|uniprotkb:B2R4L7|ensembl:ENSP00000242465	intact:EBI-5325353|ensembl:ENSP00000363079|ensembl:ENSP00000502615|ensembl:ENSP00000502789|uniprotkb:Q4VB12|uniprotkb:Q4VB13|uniprotkb:Q86SI4|uniprotkb:Q96KE4|uniprotkb:Q96TF7|uniprotkb:Q96TF8|uniprotkb:Q96TF9|uniprotkb:Q4VB14|uniprotkb:Q5SQS3	psi-mi:srgn_human(display_long)|uniprotkb:Secretory granule proteoglycan core protein(gene name synonym)|uniprotkb:Platelet proteoglycan core protein(gene name synonym)|uniprotkb:SRGN(gene name)|psi-mi:SRGN(display_short)|uniprotkb:PRG(gene name synonym)|uniprotkb:PRG1(gene name synonym)|uniprotkb:Hematopoietic proteoglycan core protein(gene name synonym)	psi-mi:mbl2_human(display_long)|uniprotkb:MBL2(gene name)|psi-mi:MBL2(display_short)|uniprotkb:COLEC1(gene name synonym)|uniprotkb:MBL(gene name synonym)|uniprotkb:Collectin-1(gene name synonym)|uniprotkb:MBP1(gene name synonym)|uniprotkb:Mannan-binding protein(gene name synonym)|uniprotkb:Mannose-binding lectin(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Skliris et al. (2011)	pubmed:21268013|imex:IM-28597	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26574117|imex:IM-28597-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002718.2|go:"GO:0042629"(mast cell granule)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:0140507"(granzyme-mediated programmed cell death signaling pathway)|interpro:IPR007455(Serglycin)|mint:P10124|reactome:R-HSA-114608|ensembl:ENSG00000122862(gene)|ensembl:ENST00000242465(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006915"(apoptotic process)|go:"GO:0016485"(protein processing)|go:"GO:0030141"(secretory granule)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0033363"(secretory granule organization)|go:"GO:0033364"(mast cell secretory granule organization)|go:"GO:0033371"(T cell secretory granule organization)|go:"GO:0033373"(maintenance of protease location in mast cell secretory granule)|go:"GO:0033382"(maintenance of granzyme B location in T cell secretory granule)|refseq:NP_001307982.1|refseq:NP_001307983.1|refseq:XP_016871881.1	ensembl:ENSG00000165471(gene)|ensembl:ENST00000373968(transcript)|ensembl:ENST00000674931(transcript)|ensembl:ENST00000675947(transcript)|go:"GO:0001867"(complement activation, lectin pathway)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005537"(mannose binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0006953"(acute-phase response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008228"(opsonization)|go:"GO:0009986"(cell surface)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048525"(negative regulation of viral process)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR001304(C-type lectin)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR016186(C-type lectin-like)|refseq:XP_011538118.1|interpro:IPR018378|interpro:IPR033990|interpro:IPR037570|rcsb pdb:1HUP|interpro:IPR016187(C-type lectin fold)|reactome:R-HSA-166662|reactome:R-HSA-166663|refseq:NP_000233.1|refseq:XP_006717924.1|dip:DIP-61381N	-	-	-	figure legend:6D|caution:"The methods section describes CS-D as having  \"..sulfate both in the 4 and 6 position of the galactosamine\" and CS-E as \"sulfate in the 2 position of the glucuronate and 6 position of the galactosamine\".  However CS-E is elsewhere (including wiki article on gags, chebi database) described as having sulfated \"carbons 4 and 6 of the GalNAc sugar\" and CS-D as having \"carbon 2 of the glucuronic acid and 6 of the GalNAc sugar\" (wiki article and pmid:22264297).  It would thus appear the methods have the gag's composition listed the \"wrong way round\"."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/18	2020/12/29	rogid:fc8Rv0C285T5/uBa6eAVR4lvW3s9606	rogid:uo0RM88uw3otObIVnOhUcOfW8yo9606	-	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:28304"	uniprotkb:P10124	intact:EBI-1379423	intact:EBI-744915|uniprotkb:Q5VW06|uniprotkb:B2R4L7|ensembl:ENSP00000242465	psi-mi:heparin(display_short)|psi-mi:"CHEBI:28304"(display_long)	psi-mi:srgn_human(display_long)|uniprotkb:Secretory granule proteoglycan core protein(gene name synonym)|uniprotkb:Platelet proteoglycan core protein(gene name synonym)|uniprotkb:SRGN(gene name)|psi-mi:SRGN(display_short)|uniprotkb:PRG(gene name synonym)|uniprotkb:PRG1(gene name synonym)|uniprotkb:Hematopoietic proteoglycan core protein(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Skliris et al. (2011)	pubmed:21268013|imex:IM-28597	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26574123|imex:IM-28597-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_002718.2|go:"GO:0042629"(mast cell granule)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:0140507"(granzyme-mediated programmed cell death signaling pathway)|interpro:IPR007455(Serglycin)|mint:P10124|reactome:R-HSA-114608|ensembl:ENSG00000122862(gene)|ensembl:ENST00000242465(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006915"(apoptotic process)|go:"GO:0016485"(protein processing)|go:"GO:0030141"(secretory granule)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0033363"(secretory granule organization)|go:"GO:0033364"(mast cell secretory granule organization)|go:"GO:0033371"(T cell secretory granule organization)|go:"GO:0033373"(maintenance of protease location in mast cell secretory granule)|go:"GO:0033382"(maintenance of granzyme B location in T cell secretory granule)|refseq:NP_001307982.1|refseq:NP_001307983.1|refseq:XP_016871881.1	-	-	-	figure legend:6D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/18	2020/12/29	-	rogid:fc8Rv0C285T5/uBa6eAVR4lvW3s9606	-	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P10124	uniprotkb:P11226	intact:EBI-744915|uniprotkb:Q5VW06|uniprotkb:B2R4L7|ensembl:ENSP00000242465	intact:EBI-5325353|ensembl:ENSP00000363079|ensembl:ENSP00000502615|ensembl:ENSP00000502789|uniprotkb:Q4VB12|uniprotkb:Q4VB13|uniprotkb:Q86SI4|uniprotkb:Q96KE4|uniprotkb:Q96TF7|uniprotkb:Q96TF8|uniprotkb:Q96TF9|uniprotkb:Q4VB14|uniprotkb:Q5SQS3	psi-mi:srgn_human(display_long)|uniprotkb:Secretory granule proteoglycan core protein(gene name synonym)|uniprotkb:Platelet proteoglycan core protein(gene name synonym)|uniprotkb:SRGN(gene name)|psi-mi:SRGN(display_short)|uniprotkb:PRG(gene name synonym)|uniprotkb:PRG1(gene name synonym)|uniprotkb:Hematopoietic proteoglycan core protein(gene name synonym)	psi-mi:mbl2_human(display_long)|uniprotkb:MBL2(gene name)|psi-mi:MBL2(display_short)|uniprotkb:COLEC1(gene name synonym)|uniprotkb:MBL(gene name synonym)|uniprotkb:Collectin-1(gene name synonym)|uniprotkb:MBP1(gene name synonym)|uniprotkb:Mannan-binding protein(gene name synonym)|uniprotkb:Mannose-binding lectin(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Skliris et al. (2011)	pubmed:21268013|imex:IM-28597	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26574123|imex:IM-28597-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002718.2|go:"GO:0042629"(mast cell granule)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:0140507"(granzyme-mediated programmed cell death signaling pathway)|interpro:IPR007455(Serglycin)|mint:P10124|reactome:R-HSA-114608|ensembl:ENSG00000122862(gene)|ensembl:ENST00000242465(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006915"(apoptotic process)|go:"GO:0016485"(protein processing)|go:"GO:0030141"(secretory granule)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0033363"(secretory granule organization)|go:"GO:0033364"(mast cell secretory granule organization)|go:"GO:0033371"(T cell secretory granule organization)|go:"GO:0033373"(maintenance of protease location in mast cell secretory granule)|go:"GO:0033382"(maintenance of granzyme B location in T cell secretory granule)|refseq:NP_001307982.1|refseq:NP_001307983.1|refseq:XP_016871881.1	ensembl:ENSG00000165471(gene)|ensembl:ENST00000373968(transcript)|ensembl:ENST00000674931(transcript)|ensembl:ENST00000675947(transcript)|go:"GO:0001867"(complement activation, lectin pathway)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005537"(mannose binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0006953"(acute-phase response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008228"(opsonization)|go:"GO:0009986"(cell surface)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048525"(negative regulation of viral process)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR001304(C-type lectin)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR016186(C-type lectin-like)|refseq:XP_011538118.1|interpro:IPR018378|interpro:IPR033990|interpro:IPR037570|rcsb pdb:1HUP|interpro:IPR016187(C-type lectin fold)|reactome:R-HSA-166662|reactome:R-HSA-166663|refseq:NP_000233.1|refseq:XP_006717924.1|dip:DIP-61381N	-	-	-	figure legend:6D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/18	2020/12/29	rogid:fc8Rv0C285T5/uBa6eAVR4lvW3s9606	rogid:uo0RM88uw3otObIVnOhUcOfW8yo9606	-	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:37397"	uniprotkb:P10124	intact:EBI-9673920|chebi:"CHEBI:23224"|chebi:"CHEBI:3676"	intact:EBI-744915|uniprotkb:Q5VW06|uniprotkb:B2R4L7|ensembl:ENSP00000242465	psi-mi:chondroitin sulfate-1(display_short)|psi-mi:"CHEBI:37397"(display_long)|intact:chondroitin polysulfate(synonym)|intact:Chondroitin sulfate(synonym)|intact:chondroitin sulfates(synonym)|intact:chondroitin sulfuric acid(synonym)|intact:chondroitin sulphate(synonym)|intact:Chondroitinsulfat(synonym)	psi-mi:srgn_human(display_long)|uniprotkb:Secretory granule proteoglycan core protein(gene name synonym)|uniprotkb:Platelet proteoglycan core protein(gene name synonym)|uniprotkb:SRGN(gene name)|psi-mi:SRGN(display_short)|uniprotkb:PRG(gene name synonym)|uniprotkb:PRG1(gene name synonym)|uniprotkb:Hematopoietic proteoglycan core protein(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Skliris et al. (2011)	pubmed:21268013|imex:IM-28597	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26574136|imex:IM-28597-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_002718.2|go:"GO:0042629"(mast cell granule)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:0140507"(granzyme-mediated programmed cell death signaling pathway)|interpro:IPR007455(Serglycin)|mint:P10124|reactome:R-HSA-114608|ensembl:ENSG00000122862(gene)|ensembl:ENST00000242465(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006915"(apoptotic process)|go:"GO:0016485"(protein processing)|go:"GO:0030141"(secretory granule)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0033363"(secretory granule organization)|go:"GO:0033364"(mast cell secretory granule organization)|go:"GO:0033371"(T cell secretory granule organization)|go:"GO:0033373"(maintenance of protease location in mast cell secretory granule)|go:"GO:0033382"(maintenance of granzyme B location in T cell secretory granule)|refseq:NP_001307982.1|refseq:NP_001307983.1|refseq:XP_016871881.1	-	-	-	figure legend:6D|comment:"Serglycin-derived Chondroitin Sulfate is stated to be constituted by  \"4-sulfated disaccharides (92.5%), low amounts of six-sulfated disac-  charides (4.5%) and only trace amounts of non-sulfated (1.5%) and (4,6)-disulfated units (1.5%)\"."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/18	2020/12/29	-	rogid:fc8Rv0C285T5/uBa6eAVR4lvW3s9606	-	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P10124	uniprotkb:P11226	intact:EBI-744915|uniprotkb:Q5VW06|uniprotkb:B2R4L7|ensembl:ENSP00000242465	intact:EBI-5325353|ensembl:ENSP00000363079|ensembl:ENSP00000502615|ensembl:ENSP00000502789|uniprotkb:Q4VB12|uniprotkb:Q4VB13|uniprotkb:Q86SI4|uniprotkb:Q96KE4|uniprotkb:Q96TF7|uniprotkb:Q96TF8|uniprotkb:Q96TF9|uniprotkb:Q4VB14|uniprotkb:Q5SQS3	psi-mi:srgn_human(display_long)|uniprotkb:Secretory granule proteoglycan core protein(gene name synonym)|uniprotkb:Platelet proteoglycan core protein(gene name synonym)|uniprotkb:SRGN(gene name)|psi-mi:SRGN(display_short)|uniprotkb:PRG(gene name synonym)|uniprotkb:PRG1(gene name synonym)|uniprotkb:Hematopoietic proteoglycan core protein(gene name synonym)	psi-mi:mbl2_human(display_long)|uniprotkb:MBL2(gene name)|psi-mi:MBL2(display_short)|uniprotkb:COLEC1(gene name synonym)|uniprotkb:MBL(gene name synonym)|uniprotkb:Collectin-1(gene name synonym)|uniprotkb:MBP1(gene name synonym)|uniprotkb:Mannan-binding protein(gene name synonym)|uniprotkb:Mannose-binding lectin(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Skliris et al. (2011)	pubmed:21268013|imex:IM-28597	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26574136|imex:IM-28597-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002718.2|go:"GO:0042629"(mast cell granule)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:0140507"(granzyme-mediated programmed cell death signaling pathway)|interpro:IPR007455(Serglycin)|mint:P10124|reactome:R-HSA-114608|ensembl:ENSG00000122862(gene)|ensembl:ENST00000242465(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006915"(apoptotic process)|go:"GO:0016485"(protein processing)|go:"GO:0030141"(secretory granule)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0033363"(secretory granule organization)|go:"GO:0033364"(mast cell secretory granule organization)|go:"GO:0033371"(T cell secretory granule organization)|go:"GO:0033373"(maintenance of protease location in mast cell secretory granule)|go:"GO:0033382"(maintenance of granzyme B location in T cell secretory granule)|refseq:NP_001307982.1|refseq:NP_001307983.1|refseq:XP_016871881.1	ensembl:ENSG00000165471(gene)|ensembl:ENST00000373968(transcript)|ensembl:ENST00000674931(transcript)|ensembl:ENST00000675947(transcript)|go:"GO:0001867"(complement activation, lectin pathway)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005537"(mannose binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0006953"(acute-phase response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008228"(opsonization)|go:"GO:0009986"(cell surface)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048525"(negative regulation of viral process)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR001304(C-type lectin)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR016186(C-type lectin-like)|refseq:XP_011538118.1|interpro:IPR018378|interpro:IPR033990|interpro:IPR037570|rcsb pdb:1HUP|interpro:IPR016187(C-type lectin fold)|reactome:R-HSA-166662|reactome:R-HSA-166663|refseq:NP_000233.1|refseq:XP_006717924.1|dip:DIP-61381N	-	-	-	figure legend:6D|comment:"Serglycin-derived Chondroitin Sulfate is stated to be constituted by  \"4-sulfated disaccharides (92.5%), low amounts of six-sulfated disac-  charides (4.5%) and only trace amounts of non-sulfated (1.5%) and (4,6)-disulfated units (1.5%)\"."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/18	2020/12/29	rogid:fc8Rv0C285T5/uBa6eAVR4lvW3s9606	rogid:uo0RM88uw3otObIVnOhUcOfW8yo9606	-	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
matrixdb:MULT_82_human	uniprotkb:P10124	intact:EBI-6264901|reactome:R-HSA-173579|wwpdb:1PK6|wwpdb:2wnv|wwpdb:2jg8|wwpdb:2jg9|wwpdb:2wnu|reactome:R-HSA-173588	intact:EBI-744915|uniprotkb:Q5VW06|uniprotkb:B2R4L7|ensembl:ENSP00000242465	psi-mi:c1q_human(display_short)|psi-mi:MULT_82_human(display_long)|intact:Complement component C1q complex(complex recommended name)|intact:C1q(complex synonym)|intact:Complement 1q(complex synonym)|intact:C1QA-C1QB-C1QC complex(complex synonym)|intact:"6xC1QA:6xC1QB:6xC1QC"(complex systematic name)	psi-mi:srgn_human(display_long)|uniprotkb:Secretory granule proteoglycan core protein(gene name synonym)|uniprotkb:Platelet proteoglycan core protein(gene name synonym)|uniprotkb:SRGN(gene name)|psi-mi:SRGN(display_short)|uniprotkb:PRG(gene name synonym)|uniprotkb:PRG1(gene name synonym)|uniprotkb:Hematopoietic proteoglycan core protein(gene name synonym)	psi-mi:"MI:0892"(solid phase assay)	Skliris et al. (2011)	pubmed:21268013|imex:IM-28597	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26573671|imex:IM-28597-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:0326"(protein)	go:"GO:0005509"(calcium ion binding)|go:"GO:0019865"(immunoglobulin binding)|efo:"MONDO:0013343"(see-also)|pubmed:28601358(see-also)|pubmed:22536204(see-also)|intact:EBI-6264878(exp-evidence)|evidence ontology:"ECO:0000353"|complex portal:CPX-1919(complex-primary)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0005576"(extracellular region)|pubmed:20548024(see-also)|pubmed:29449492(see-also)|pubmed:18250442(see-also)|go:"GO:0062167"(complement component C1q complex)|pubmed:31165008(see-also)|pubmed:27914690(see-also)|pubmed:26489954(see-also)	refseq:NP_002718.2|go:"GO:0042629"(mast cell granule)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:0140507"(granzyme-mediated programmed cell death signaling pathway)|interpro:IPR007455(Serglycin)|mint:P10124|reactome:R-HSA-114608|ensembl:ENSG00000122862(gene)|ensembl:ENST00000242465(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006915"(apoptotic process)|go:"GO:0016485"(protein processing)|go:"GO:0030141"(secretory granule)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0033363"(secretory granule organization)|go:"GO:0033364"(mast cell secretory granule organization)|go:"GO:0033371"(T cell secretory granule organization)|go:"GO:0033373"(maintenance of protease location in mast cell secretory granule)|go:"GO:0033382"(maintenance of granzyme B location in T cell secretory granule)|refseq:NP_001307982.1|refseq:NP_001307983.1|refseq:XP_016871881.1	-	disease:"Complement component C1q deficiency (C1QD) [MONDO:0013343]: a disorder caused by impaired activation of the complement classical pathway. It generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis."|complex-properties:The complex comprises of six heterotrimeric collagen-like triple helices, formed from triplets of the A, B, and C chains, that associate in their N-terminal half to form a stalk, then diverge to form individual stems, each terminating in a C-terminal globular domain. Each of the six heterotrimeric globular heads or domains is made up of the globular domains from one A, one B, and one C chain, each of which in turn has its own ligand specificity. The six collagen-like stalks appear to be fibril-like and exist in the central region. The collagen-like region and the globular heads can independently interact with a multiplicity of biological structures including pathogen-associated and cell associated molecules, also each of the individual globular head domains is capable of independently interacting with specific ligands. Chains A and B are disulfide-linked whilst the C chain forms a disulfide bond with the C chain of the next strand.     Molecular weight 460 kDa.|curated-complex:"Recognition unit of the classical pathway of complement which associates with the Ca2+ - dependent C1r(2)-C1s(2) tetramer to form C1 (CPX-1920), the first component of the classical complement system. The complex's role in C1 is the recognition of immune complexes, or other molecules, which trigger the classical pathway of the complement system. Independent of complement activation C1q appears to have additional roles in homeostasis and cellular development, superoxide (O2-) production by neutrophils, blood coagulation and neurological synapse pruning."|complex-assembly:Heterooctadecamer	-	figure legend:4B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/18	2020/12/29	-	rogid:fc8Rv0C285T5/uBa6eAVR4lvW3s9606	-	false	-	125i radiolabel:?-?	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)