#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P11226 uniprotkb:P11226 intact:EBI-5325353|ensembl:ENSP00000363079|ensembl:ENSP00000502615|ensembl:ENSP00000502789|uniprotkb:Q4VB12|uniprotkb:Q4VB13|uniprotkb:Q86SI4|uniprotkb:Q96KE4|uniprotkb:Q96TF7|uniprotkb:Q96TF8|uniprotkb:Q96TF9|uniprotkb:Q4VB14|uniprotkb:Q5SQS3 intact:EBI-5325353|ensembl:ENSP00000363079|ensembl:ENSP00000502615|ensembl:ENSP00000502789|uniprotkb:Q4VB12|uniprotkb:Q4VB13|uniprotkb:Q86SI4|uniprotkb:Q96KE4|uniprotkb:Q96TF7|uniprotkb:Q96TF8|uniprotkb:Q96TF9|uniprotkb:Q4VB14|uniprotkb:Q5SQS3 psi-mi:mbl2_human(display_long)|uniprotkb:MBL2(gene name)|psi-mi:MBL2(display_short)|uniprotkb:COLEC1(gene name synonym)|uniprotkb:MBL(gene name synonym)|uniprotkb:Collectin-1(gene name synonym)|uniprotkb:MBP1(gene name synonym)|uniprotkb:Mannan-binding protein(gene name synonym)|uniprotkb:Mannose-binding lectin(gene name synonym) psi-mi:mbl2_human(display_long)|uniprotkb:MBL2(gene name)|psi-mi:MBL2(display_short)|uniprotkb:COLEC1(gene name synonym)|uniprotkb:MBL(gene name synonym)|uniprotkb:Collectin-1(gene name synonym)|uniprotkb:MBP1(gene name synonym)|uniprotkb:Mannan-binding protein(gene name synonym)|uniprotkb:Mannose-binding lectin(gene name synonym) psi-mi:"MI:0404"(comigration in non denaturing gel electrophoresis) Ma et al. (2011) pubmed:21106539|imex:IM-28592 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26572809|imex:IM-28592-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000165471(gene)|ensembl:ENST00000373968(transcript)|ensembl:ENST00000674931(transcript)|ensembl:ENST00000675947(transcript)|go:"GO:0001867"(complement activation, lectin pathway)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005537"(mannose binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0006953"(acute-phase response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008228"(opsonization)|go:"GO:0009986"(cell surface)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048525"(negative regulation of viral process)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR001304(C-type lectin)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR016186(C-type lectin-like)|refseq:XP_011538118.1|interpro:IPR018378|interpro:IPR033990|interpro:IPR037570|rcsb pdb:1HUP|interpro:IPR016187(C-type lectin fold)|reactome:R-HSA-166662|reactome:R-HSA-166663|refseq:NP_000233.1|refseq:XP_006717924.1|dip:DIP-61381N ensembl:ENSG00000165471(gene)|ensembl:ENST00000373968(transcript)|ensembl:ENST00000674931(transcript)|ensembl:ENST00000675947(transcript)|go:"GO:0001867"(complement activation, lectin pathway)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005537"(mannose binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0006953"(acute-phase response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008228"(opsonization)|go:"GO:0009986"(cell surface)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048525"(negative regulation of viral process)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR001304(C-type lectin)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR016186(C-type lectin-like)|refseq:XP_011538118.1|interpro:IPR018378|interpro:IPR033990|interpro:IPR037570|rcsb pdb:1HUP|interpro:IPR016187(C-type lectin fold)|reactome:R-HSA-166662|reactome:R-HSA-166663|refseq:NP_000233.1|refseq:XP_006717924.1|dip:DIP-61381N - - - figure legend:Supp. figure 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10029(crigr-cho)|taxid:10029(chinese hamster ovary cell line) - 2020/12/18 2020/12/28 rogid:uo0RM88uw3otObIVnOhUcOfW8yo9606 rogid:uo0RM88uw3otObIVnOhUcOfW8yo9606 rigid:FWt5tJQi8fdRtsjhZvaCNxg1xT4 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) chebi:"CHEBI:28808" uniprotkb:P26022 intact:EBI-25613000|chebi:"CHEBI:6684"|chebi:"CHEBI:25159" intact:EBI-11574553|uniprotkb:B2R6T6|uniprotkb:Q38M82|ensembl:ENSP00000295927 psi-mi:mannan(display_short)|psi-mi:"CHEBI:28808"(display_long)|intact:Mannan(synonym)|intact:mannans(synonym)|intact:Mannoglycan(synonym)|intact:mannan(iupac name) psi-mi:ptx3_human(display_long)|uniprotkb:Pentaxin-related protein PTX3(gene name synonym)|uniprotkb:TNFAIP5(gene name synonym)|uniprotkb:TSG14(gene name synonym)|uniprotkb:Tumor necrosis factor alpha-induced protein 5(gene name synonym)|uniprotkb:Tumor necrosis factor-inducible gene 14 protein(gene name synonym)|uniprotkb:PTX3(gene name)|psi-mi:PTX3(display_short) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) Ma et al. (2011) pubmed:21106539|imex:IM-28592 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-26572820|imex:IM-28592-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - refseq:NP_002843.2|ensembl:ENSG00000163661(gene)|ensembl:ENST00000295927(transcript)|go:"GO:0001550"(ovarian cumulus expansion)|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0001872"("(1->3)-beta-D-glucan binding")|go:"GO:0001878"(response to yeast)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0008228"(opsonization)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035580"(specific granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0044793"(negative regulation by host of viral process)|go:"GO:0044869"(negative regulation by host of viral exo-alpha-sialidase activity)|go:"GO:0044871"(negative regulation by host of viral glycoprotein metabolic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0046790"(virion binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:1903016"(negative regulation of exo-alpha-sialidase activity)|go:"GO:1903019"(negative regulation of glycoprotein metabolic process)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR001759(Pentaxin)|interpro:IPR006558(LamG-like jellyroll fold)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR030476|interpro:IPR042837|reactome:R-HSA-6798695 - - - figure legend:1A, Supp. figure 2A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/12/18 2020/12/28 - rogid:E2p0QaxS5/8mpgyOghoPCB+WHx09606 - false - - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) chebi:"CHEBI:28808" uniprotkb:P11226 intact:EBI-25613000|chebi:"CHEBI:6684"|chebi:"CHEBI:25159" intact:EBI-5325353|ensembl:ENSP00000363079|ensembl:ENSP00000502615|ensembl:ENSP00000502789|uniprotkb:Q4VB12|uniprotkb:Q4VB13|uniprotkb:Q86SI4|uniprotkb:Q96KE4|uniprotkb:Q96TF7|uniprotkb:Q96TF8|uniprotkb:Q96TF9|uniprotkb:Q4VB14|uniprotkb:Q5SQS3 psi-mi:mannan(display_short)|psi-mi:"CHEBI:28808"(display_long)|intact:Mannan(synonym)|intact:mannans(synonym)|intact:Mannoglycan(synonym)|intact:mannan(iupac name) psi-mi:mbl2_human(display_long)|uniprotkb:MBL2(gene name)|psi-mi:MBL2(display_short)|uniprotkb:COLEC1(gene name synonym)|uniprotkb:MBL(gene name synonym)|uniprotkb:Collectin-1(gene name synonym)|uniprotkb:MBP1(gene name synonym)|uniprotkb:Mannan-binding protein(gene name synonym)|uniprotkb:Mannose-binding lectin(gene name synonym) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) Ma et al. (2011) pubmed:21106539|imex:IM-28592 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-26572820|imex:IM-28592-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0684"(ancillary) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - ensembl:ENSG00000165471(gene)|ensembl:ENST00000373968(transcript)|ensembl:ENST00000674931(transcript)|ensembl:ENST00000675947(transcript)|go:"GO:0001867"(complement activation, lectin pathway)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005537"(mannose binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0006953"(acute-phase response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008228"(opsonization)|go:"GO:0009986"(cell surface)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048525"(negative regulation of viral process)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR001304(C-type lectin)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR016186(C-type lectin-like)|refseq:XP_011538118.1|interpro:IPR018378|interpro:IPR033990|interpro:IPR037570|rcsb pdb:1HUP|interpro:IPR016187(C-type lectin fold)|reactome:R-HSA-166662|reactome:R-HSA-166663|refseq:NP_000233.1|refseq:XP_006717924.1|dip:DIP-61381N - - - figure legend:1A, Supp. figure 2A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/12/18 2020/12/28 - rogid:uo0RM88uw3otObIVnOhUcOfW8yo9606 - false - - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P02743 uniprotkb:P11226 intact:EBI-2115799|ensembl:ENSP00000255040 intact:EBI-5325353|ensembl:ENSP00000363079|ensembl:ENSP00000502615|ensembl:ENSP00000502789|uniprotkb:Q4VB12|uniprotkb:Q4VB13|uniprotkb:Q86SI4|uniprotkb:Q96KE4|uniprotkb:Q96TF7|uniprotkb:Q96TF8|uniprotkb:Q96TF9|uniprotkb:Q4VB14|uniprotkb:Q5SQS3 psi-mi:samp_human(display_long)|uniprotkb:APCS(gene name)|psi-mi:APCS(display_short)|uniprotkb:PTX2(gene name synonym)|uniprotkb:9.5S alpha-1-glycoprotein(gene name synonym) psi-mi:mbl2_human(display_long)|uniprotkb:MBL2(gene name)|psi-mi:MBL2(display_short)|uniprotkb:COLEC1(gene name synonym)|uniprotkb:MBL(gene name synonym)|uniprotkb:Collectin-1(gene name synonym)|uniprotkb:MBP1(gene name synonym)|uniprotkb:Mannan-binding protein(gene name synonym)|uniprotkb:Mannose-binding lectin(gene name synonym) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) Ma et al. (2011) pubmed:21106539|imex:IM-28592 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-26572825|imex:IM-28592-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001630.1|dip:DIP-46911N|ensembl:ENSG00000132703(gene)|ensembl:ENST00000255040(transcript)|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0002674"(negative regulation of acute inflammatory response)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0006457"(protein folding)|go:"GO:0006953"(acute-phase response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044793"(negative regulation by host of viral process)|go:"GO:0044869"(negative regulation by host of viral exo-alpha-sialidase activity)|go:"GO:0044871"(negative regulation by host of viral glycoprotein metabolic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0046790"(virion binding)|go:"GO:0048525"(negative regulation of viral process)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:1903016"(negative regulation of exo-alpha-sialidase activity)|go:"GO:1903019"(negative regulation of glycoprotein metabolic process)|interpro:IPR001759(Pentaxin)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR030476|rcsb pdb:1GYK|rcsb pdb:1LGN|rcsb pdb:1SAC|rcsb pdb:2A3W|rcsb pdb:2A3X|rcsb pdb:2A3Y|rcsb pdb:2W08|rcsb pdb:3D5O|rcsb pdb:3KQR|rcsb pdb:4AVS|rcsb pdb:4AVT|rcsb pdb:4AVV|rcsb pdb:4AYU|reactome:R-HSA-977225 ensembl:ENSG00000165471(gene)|ensembl:ENST00000373968(transcript)|ensembl:ENST00000674931(transcript)|ensembl:ENST00000675947(transcript)|go:"GO:0001867"(complement activation, lectin pathway)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005537"(mannose binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0006953"(acute-phase response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008228"(opsonization)|go:"GO:0009986"(cell surface)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048525"(negative regulation of viral process)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR001304(C-type lectin)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR016186(C-type lectin-like)|refseq:XP_011538118.1|interpro:IPR018378|interpro:IPR033990|interpro:IPR037570|rcsb pdb:1HUP|interpro:IPR016187(C-type lectin fold)|reactome:R-HSA-166662|reactome:R-HSA-166663|refseq:NP_000233.1|refseq:XP_006717924.1|dip:DIP-61381N - - - figure legend:1B, Supp. figure 2B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/12/18 2020/12/28 rogid:WOzyPFzTtaBN2E4vVhJyXLGNLcY9606 rogid:uo0RM88uw3otObIVnOhUcOfW8yo9606 rigid:YI7sRwCeMErbrZ/ZJUQ2uFn+mwQ false - - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P26022 uniprotkb:P11226 intact:EBI-11574553|uniprotkb:B2R6T6|uniprotkb:Q38M82|ensembl:ENSP00000295927 intact:EBI-5325353|ensembl:ENSP00000363079|ensembl:ENSP00000502615|ensembl:ENSP00000502789|uniprotkb:Q4VB12|uniprotkb:Q4VB13|uniprotkb:Q86SI4|uniprotkb:Q96KE4|uniprotkb:Q96TF7|uniprotkb:Q96TF8|uniprotkb:Q96TF9|uniprotkb:Q4VB14|uniprotkb:Q5SQS3 psi-mi:ptx3_human(display_long)|uniprotkb:Pentaxin-related protein PTX3(gene name synonym)|uniprotkb:TNFAIP5(gene name synonym)|uniprotkb:TSG14(gene name synonym)|uniprotkb:Tumor necrosis factor alpha-induced protein 5(gene name synonym)|uniprotkb:Tumor necrosis factor-inducible gene 14 protein(gene name synonym)|uniprotkb:PTX3(gene name)|psi-mi:PTX3(display_short) psi-mi:mbl2_human(display_long)|uniprotkb:MBL2(gene name)|psi-mi:MBL2(display_short)|uniprotkb:COLEC1(gene name synonym)|uniprotkb:MBL(gene name synonym)|uniprotkb:Collectin-1(gene name synonym)|uniprotkb:MBP1(gene name synonym)|uniprotkb:Mannan-binding protein(gene name synonym)|uniprotkb:Mannose-binding lectin(gene name synonym) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) Ma et al. (2011) pubmed:21106539|imex:IM-28592 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-26572830|imex:IM-28592-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002843.2|ensembl:ENSG00000163661(gene)|ensembl:ENST00000295927(transcript)|go:"GO:0001550"(ovarian cumulus expansion)|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0001872"("(1->3)-beta-D-glucan binding")|go:"GO:0001878"(response to yeast)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0008228"(opsonization)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035580"(specific granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0044793"(negative regulation by host of viral process)|go:"GO:0044869"(negative regulation by host of viral exo-alpha-sialidase activity)|go:"GO:0044871"(negative regulation by host of viral glycoprotein metabolic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0046790"(virion binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:1903016"(negative regulation of exo-alpha-sialidase activity)|go:"GO:1903019"(negative regulation of glycoprotein metabolic process)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR001759(Pentaxin)|interpro:IPR006558(LamG-like jellyroll fold)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR030476|interpro:IPR042837|reactome:R-HSA-6798695 ensembl:ENSG00000165471(gene)|ensembl:ENST00000373968(transcript)|ensembl:ENST00000674931(transcript)|ensembl:ENST00000675947(transcript)|go:"GO:0001867"(complement activation, lectin pathway)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005537"(mannose binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0006953"(acute-phase response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008228"(opsonization)|go:"GO:0009986"(cell surface)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048525"(negative regulation of viral process)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR001304(C-type lectin)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR016186(C-type lectin-like)|refseq:XP_011538118.1|interpro:IPR018378|interpro:IPR033990|interpro:IPR037570|rcsb pdb:1HUP|interpro:IPR016187(C-type lectin fold)|reactome:R-HSA-166662|reactome:R-HSA-166663|refseq:NP_000233.1|refseq:XP_006717924.1|dip:DIP-61381N - - - figure legend:4A|agonist:"Ca2+ (CHEBI:29108)"|antagonist:"EDTA (CHEBI:42191)"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/12/18 2020/12/28 rogid:E2p0QaxS5/8mpgyOghoPCB+WHx09606 rogid:uo0RM88uw3otObIVnOhUcOfW8yo9606 rigid:SQ1VarPUwihh3qNwsbIn8CWtHq0 false - - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P02743 uniprotkb:P11226 intact:EBI-2115799|ensembl:ENSP00000255040 intact:EBI-5325353|ensembl:ENSP00000363079|ensembl:ENSP00000502615|ensembl:ENSP00000502789|uniprotkb:Q4VB12|uniprotkb:Q4VB13|uniprotkb:Q86SI4|uniprotkb:Q96KE4|uniprotkb:Q96TF7|uniprotkb:Q96TF8|uniprotkb:Q96TF9|uniprotkb:Q4VB14|uniprotkb:Q5SQS3 psi-mi:samp_human(display_long)|uniprotkb:APCS(gene name)|psi-mi:APCS(display_short)|uniprotkb:PTX2(gene name synonym)|uniprotkb:9.5S alpha-1-glycoprotein(gene name synonym) psi-mi:mbl2_human(display_long)|uniprotkb:MBL2(gene name)|psi-mi:MBL2(display_short)|uniprotkb:COLEC1(gene name synonym)|uniprotkb:MBL(gene name synonym)|uniprotkb:Collectin-1(gene name synonym)|uniprotkb:MBP1(gene name synonym)|uniprotkb:Mannan-binding protein(gene name synonym)|uniprotkb:Mannose-binding lectin(gene name synonym) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) Ma et al. (2011) pubmed:21106539|imex:IM-28592 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-26572837|imex:IM-28592-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001630.1|dip:DIP-46911N|ensembl:ENSG00000132703(gene)|ensembl:ENST00000255040(transcript)|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0002674"(negative regulation of acute inflammatory response)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0006457"(protein folding)|go:"GO:0006953"(acute-phase response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044793"(negative regulation by host of viral process)|go:"GO:0044869"(negative regulation by host of viral exo-alpha-sialidase activity)|go:"GO:0044871"(negative regulation by host of viral glycoprotein metabolic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0046790"(virion binding)|go:"GO:0048525"(negative regulation of viral process)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:1903016"(negative regulation of exo-alpha-sialidase activity)|go:"GO:1903019"(negative regulation of glycoprotein metabolic process)|interpro:IPR001759(Pentaxin)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR030476|rcsb pdb:1GYK|rcsb pdb:1LGN|rcsb pdb:1SAC|rcsb pdb:2A3W|rcsb pdb:2A3X|rcsb pdb:2A3Y|rcsb pdb:2W08|rcsb pdb:3D5O|rcsb pdb:3KQR|rcsb pdb:4AVS|rcsb pdb:4AVT|rcsb pdb:4AVV|rcsb pdb:4AYU|reactome:R-HSA-977225 ensembl:ENSG00000165471(gene)|ensembl:ENST00000373968(transcript)|ensembl:ENST00000674931(transcript)|ensembl:ENST00000675947(transcript)|go:"GO:0001867"(complement activation, lectin pathway)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005537"(mannose binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0006953"(acute-phase response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008228"(opsonization)|go:"GO:0009986"(cell surface)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048525"(negative regulation of viral process)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR001304(C-type lectin)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR016186(C-type lectin-like)|refseq:XP_011538118.1|interpro:IPR018378|interpro:IPR033990|interpro:IPR037570|rcsb pdb:1HUP|interpro:IPR016187(C-type lectin fold)|reactome:R-HSA-166662|reactome:R-HSA-166663|refseq:NP_000233.1|refseq:XP_006717924.1|dip:DIP-61381N - - - figure legend:4B|agonist:"Ca2+ (CHEBI:29108)"|antagonist:"EDTA (CHEBI:42191)"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/12/18 2020/12/28 rogid:WOzyPFzTtaBN2E4vVhJyXLGNLcY9606 rogid:uo0RM88uw3otObIVnOhUcOfW8yo9606 rigid:YI7sRwCeMErbrZ/ZJUQ2uFn+mwQ false - - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody)