#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9NV96	uniprotkb:O43520	intact:EBI-2836942|uniprotkb:A8K9V8|uniprotkb:Q96H09|uniprotkb:Q9NSL9|uniprotkb:Q658Z3|uniprotkb:E1P539|ensembl:ENSP00000230461	intact:EBI-9524729|uniprotkb:Q9BTP8|intact:EBI-28976955|ensembl:ENSP00000497896	psi-mi:cc50a_human(display_long)|uniprotkb:TMEM30A(gene name)|psi-mi:TMEM30A(display_short)|uniprotkb:C6orf67(gene name synonym)|uniprotkb:CDC50A(gene name synonym)|uniprotkb:Transmembrane protein 30A(gene name synonym)|uniprotkb:P4-ATPase flippase complex beta subunit TMEM30A(gene name synonym)	psi-mi:at8b1_human(display_long)|uniprotkb:P4-ATPase flippase complex alpha subunit ATP8B1(gene name synonym)|uniprotkb:ATP8B1(gene name)|psi-mi:ATP8B1(display_short)|uniprotkb:ATPIC(gene name synonym)|uniprotkb:FIC1(gene name synonym)|uniprotkb:PFIC(gene name synonym)|uniprotkb:ATPase class I type 8B member 1(gene name synonym)|uniprotkb:Familial intrahepatic cholestasis type 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bryde et al. (2010)	pubmed:20961850|imex:IM-28476	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26441578|imex:IM-28476-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001137430.1|refseq:NP_060717.1|ensembl:ENSG00000112697(gene)|ensembl:ENST00000230461(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006855"(xenobiotic transmembrane transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015247"(aminophospholipid flippase activity)|go:"GO:0015917"(aminophospholipid transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0036010"(protein localization to endosome)|go:"GO:0045332"(phospholipid translocation)|go:"GO:0061092"(positive regulation of phospholipid translocation)|go:"GO:0070863"(positive regulation of protein exit from endoplasmic reticulum)|go:"GO:1990531"(phospholipid-translocating ATPase complex)|interpro:IPR005045(Protein of unknown function DUF284, transmembrane eukaryotic)|interpro:IPR030351|mint:Q9NV96|rcsb pdb:6K7G|rcsb pdb:6K7H|rcsb pdb:6K7I|rcsb pdb:6K7J|rcsb pdb:6K7K|rcsb pdb:6K7M|rcsb pdb:6K7N|rcsb pdb:6LKN|rcsb pdb:7BSP|rcsb pdb:7BSQ|rcsb pdb:7BSS|rcsb pdb:7BSU|rcsb pdb:7BSV|rcsb pdb:7BSW|reactome:R-HSA-6798695|rcsb pdb:6K7L	ensembl:ENSP00000497896|refseq:XP_011524324.1|refseq:XP_006722544.1|refseq:NP_005594.1|ensembl:ENSG00000081923(gene)|ensembl:ENST00000648908(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006855"(xenobiotic transmembrane transport)|go:"GO:0007030"(Golgi organization)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008206"(bile acid metabolic process)|go:"GO:0015721"(bile acid and bile salt transport)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0021650"(vestibulocochlear nerve formation)|go:"GO:0031526"(brush border membrane)|go:"GO:0032420"(stereocilium)|go:"GO:0032534"(regulation of microvillus assembly)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0045176"(apical protein localization)|go:"GO:0045332"(phospholipid translocation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0060119"(inner ear receptor cell development)|go:"GO:0140326"(ATPase-coupled intramembrane lipid transporter activity)|go:"GO:0140345"(phosphatidylcholine flippase activity)|go:"GO:0140346"(phosphatidylserine flippase activity)|go:"GO:1901612"(cardiolipin binding)|go:"GO:1903729"(regulation of plasma membrane organization)|go:"GO:1990531"(phospholipid-translocating ATPase complex)|go:"GO:2001225"(regulation of chloride transport)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR006539(Phospholipid-translocating P-type ATPase, flippase)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023298|interpro:IPR023299|interpro:IPR030346|interpro:IPR032630|interpro:IPR032631|interpro:IPR036412|interpro:IPR044492|reactome:R-HSA-936837	-	-	-	figure legend:Fig. 3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2020/11/02	2020/11/04	rogid:HTSM+3ihZsx2qIRiNhutEb/Kyu09606	rogid:etMCmFj6oGhBGan/RrxU5eUdWCM9606	rigid:2yvSqj7gC2sM/lIgVP3rtz0JSjg	false	v5 tag:c-c	his tag:c-c|ha tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q3MIR4	uniprotkb:O43520	intact:EBI-9527107|uniprotkb:B3KR84|uniprotkb:Q14D00|ensembl:ENSP00000450842	intact:EBI-9524729|uniprotkb:Q9BTP8|intact:EBI-28976955|ensembl:ENSP00000497896	psi-mi:cc50b_human(display_long)|uniprotkb:P4-ATPase flippase complex beta subunit TMEM30B(gene name synonym)|uniprotkb:TMEM30B(gene name)|psi-mi:TMEM30B(display_short)|uniprotkb:CDC50B(gene name synonym)|uniprotkb:Transmembrane protein 30B(gene name synonym)	psi-mi:at8b1_human(display_long)|uniprotkb:P4-ATPase flippase complex alpha subunit ATP8B1(gene name synonym)|uniprotkb:ATP8B1(gene name)|psi-mi:ATP8B1(display_short)|uniprotkb:ATPIC(gene name synonym)|uniprotkb:FIC1(gene name synonym)|uniprotkb:PFIC(gene name synonym)|uniprotkb:ATPase class I type 8B member 1(gene name synonym)|uniprotkb:Familial intrahepatic cholestasis type 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bryde et al. (2010)	pubmed:20961850|imex:IM-28476	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26441610|imex:IM-28476-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001017970.1|ensembl:ENSG00000182107(gene)|ensembl:ENST00000555868(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0015247"(aminophospholipid flippase activity)|go:"GO:0015917"(aminophospholipid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0045332"(phospholipid translocation)|go:"GO:0070863"(positive regulation of protein exit from endoplasmic reticulum)|interpro:IPR005045(Protein of unknown function DUF284, transmembrane eukaryotic)|interpro:IPR030352	ensembl:ENSP00000497896|refseq:XP_011524324.1|refseq:XP_006722544.1|refseq:NP_005594.1|ensembl:ENSG00000081923(gene)|ensembl:ENST00000648908(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006855"(xenobiotic transmembrane transport)|go:"GO:0007030"(Golgi organization)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008206"(bile acid metabolic process)|go:"GO:0015721"(bile acid and bile salt transport)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0021650"(vestibulocochlear nerve formation)|go:"GO:0031526"(brush border membrane)|go:"GO:0032420"(stereocilium)|go:"GO:0032534"(regulation of microvillus assembly)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0045176"(apical protein localization)|go:"GO:0045332"(phospholipid translocation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0060119"(inner ear receptor cell development)|go:"GO:0140326"(ATPase-coupled intramembrane lipid transporter activity)|go:"GO:0140345"(phosphatidylcholine flippase activity)|go:"GO:0140346"(phosphatidylserine flippase activity)|go:"GO:1901612"(cardiolipin binding)|go:"GO:1903729"(regulation of plasma membrane organization)|go:"GO:1990531"(phospholipid-translocating ATPase complex)|go:"GO:2001225"(regulation of chloride transport)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR006539(Phospholipid-translocating P-type ATPase, flippase)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023298|interpro:IPR023299|interpro:IPR030346|interpro:IPR032630|interpro:IPR032631|interpro:IPR036412|interpro:IPR044492|reactome:R-HSA-936837	-	-	-	figure legend:Fig. 3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2020/11/02	2020/11/03	rogid:SEW0dE9gp2d2piEq/37EFUxcNOI9606	rogid:etMCmFj6oGhBGan/RrxU5eUdWCM9606	rigid:GTGeuI97aNQ1cwMsV2WSwS8/TiU	false	v5 tag:c-c	ha tag:c-c|his tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9NV96	uniprotkb:P98198	intact:EBI-2836942|uniprotkb:A8K9V8|uniprotkb:Q96H09|uniprotkb:Q9NSL9|uniprotkb:Q658Z3|uniprotkb:E1P539|ensembl:ENSP00000230461	intact:EBI-9539266|uniprotkb:B4E3P4|uniprotkb:Q6NT69|uniprotkb:Q7Z486|uniprotkb:Q96I43|uniprotkb:Q96NQ7	psi-mi:cc50a_human(display_long)|uniprotkb:TMEM30A(gene name)|psi-mi:TMEM30A(display_short)|uniprotkb:C6orf67(gene name synonym)|uniprotkb:CDC50A(gene name synonym)|uniprotkb:Transmembrane protein 30A(gene name synonym)|uniprotkb:P4-ATPase flippase complex beta subunit TMEM30A(gene name synonym)	psi-mi:at8b2_human(display_long)|uniprotkb:ATP8B2(gene name)|psi-mi:ATP8B2(display_short)|uniprotkb:ATPID(gene name synonym)|uniprotkb:KIAA1137(gene name synonym)|uniprotkb:ATPase class I type 8B member 2(gene name synonym)|uniprotkb:P4-ATPase flippase complex alpha subunit ATP8B2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bryde et al. (2010)	pubmed:20961850|imex:IM-28476	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26441620|imex:IM-28476-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001137430.1|refseq:NP_060717.1|ensembl:ENSG00000112697(gene)|ensembl:ENST00000230461(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006855"(xenobiotic transmembrane transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015247"(aminophospholipid flippase activity)|go:"GO:0015917"(aminophospholipid transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0036010"(protein localization to endosome)|go:"GO:0045332"(phospholipid translocation)|go:"GO:0061092"(positive regulation of phospholipid translocation)|go:"GO:0070863"(positive regulation of protein exit from endoplasmic reticulum)|go:"GO:1990531"(phospholipid-translocating ATPase complex)|interpro:IPR005045(Protein of unknown function DUF284, transmembrane eukaryotic)|interpro:IPR030351|mint:Q9NV96|rcsb pdb:6K7G|rcsb pdb:6K7H|rcsb pdb:6K7I|rcsb pdb:6K7J|rcsb pdb:6K7K|rcsb pdb:6K7M|rcsb pdb:6K7N|rcsb pdb:6LKN|rcsb pdb:7BSP|rcsb pdb:7BSQ|rcsb pdb:7BSS|rcsb pdb:7BSU|rcsb pdb:7BSV|rcsb pdb:7BSW|reactome:R-HSA-6798695|rcsb pdb:6K7L	interpro:IPR023214|interpro:IPR030347|reactome:R-HSA-936837|interpro:IPR032630|interpro:IPR032631|interpro:IPR044492|interpro:IPR023299|interpro:IPR018303|interpro:IPR006539(Phospholipid-translocating P-type ATPase, flippase)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|refseq:NP_001005855.1|refseq:NP_065185.1|refseq:XP_005245412.1|interpro:IPR023298|go:"GO:0000287"(magnesium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007030"(Golgi organization)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0045332"(phospholipid translocation)|go:"GO:0140326"(ATPase-coupled intramembrane lipid transporter activity)|go:"GO:0140345"(phosphatidylcholine flippase activity)|interpro:IPR036412	-	-	-	figure legend:Fig. 3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2020/11/02	2020/11/03	rogid:HTSM+3ihZsx2qIRiNhutEb/Kyu09606	rogid:0qfmiw+yRBCQbBg9vx2Wzsmy53Y9606	rigid:SjmygEkeYryN4j6DniVzbCkHwuk	false	v5 tag:c-c	his tag:c-c|ha tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P98198	uniprotkb:Q3MIR4	intact:EBI-9539266|uniprotkb:B4E3P4|uniprotkb:Q6NT69|uniprotkb:Q7Z486|uniprotkb:Q96I43|uniprotkb:Q96NQ7	intact:EBI-9527107|uniprotkb:B3KR84|uniprotkb:Q14D00|ensembl:ENSP00000450842	psi-mi:at8b2_human(display_long)|uniprotkb:ATP8B2(gene name)|psi-mi:ATP8B2(display_short)|uniprotkb:ATPID(gene name synonym)|uniprotkb:KIAA1137(gene name synonym)|uniprotkb:ATPase class I type 8B member 2(gene name synonym)|uniprotkb:P4-ATPase flippase complex alpha subunit ATP8B2(gene name synonym)	psi-mi:cc50b_human(display_long)|uniprotkb:P4-ATPase flippase complex beta subunit TMEM30B(gene name synonym)|uniprotkb:TMEM30B(gene name)|psi-mi:TMEM30B(display_short)|uniprotkb:CDC50B(gene name synonym)|uniprotkb:Transmembrane protein 30B(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bryde et al. (2010)	pubmed:20961850|imex:IM-28476	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26441630|imex:IM-28476-23	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR023214|interpro:IPR030347|reactome:R-HSA-936837|interpro:IPR032630|interpro:IPR032631|interpro:IPR044492|interpro:IPR023299|interpro:IPR018303|interpro:IPR006539(Phospholipid-translocating P-type ATPase, flippase)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|refseq:NP_001005855.1|refseq:NP_065185.1|refseq:XP_005245412.1|interpro:IPR023298|go:"GO:0000287"(magnesium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007030"(Golgi organization)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0045332"(phospholipid translocation)|go:"GO:0140326"(ATPase-coupled intramembrane lipid transporter activity)|go:"GO:0140345"(phosphatidylcholine flippase activity)|interpro:IPR036412	refseq:NP_001017970.1|ensembl:ENSG00000182107(gene)|ensembl:ENST00000555868(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0015247"(aminophospholipid flippase activity)|go:"GO:0015917"(aminophospholipid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0045332"(phospholipid translocation)|go:"GO:0070863"(positive regulation of protein exit from endoplasmic reticulum)|interpro:IPR005045(Protein of unknown function DUF284, transmembrane eukaryotic)|interpro:IPR030352	-	-	-	figure legend:Fig. 3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2020/11/02	2020/11/03	rogid:0qfmiw+yRBCQbBg9vx2Wzsmy53Y9606	rogid:SEW0dE9gp2d2piEq/37EFUxcNOI9606	rigid:LpwWqSvvYxH0XAlPUGLkdxbN/N0	false	his tag:c-c|ha tag:c-c	v5 tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9NV96	uniprotkb:Q8TF62	intact:EBI-2836942|uniprotkb:A8K9V8|uniprotkb:Q96H09|uniprotkb:Q9NSL9|uniprotkb:Q658Z3|uniprotkb:E1P539|ensembl:ENSP00000230461	intact:EBI-9527207|uniprotkb:Q9H727|ensembl:ENSP00000284509|ensembl:ENSP00000453169	psi-mi:cc50a_human(display_long)|uniprotkb:TMEM30A(gene name)|psi-mi:TMEM30A(display_short)|uniprotkb:C6orf67(gene name synonym)|uniprotkb:CDC50A(gene name synonym)|uniprotkb:Transmembrane protein 30A(gene name synonym)|uniprotkb:P4-ATPase flippase complex beta subunit TMEM30A(gene name synonym)	psi-mi:at8b4_human(display_long)|uniprotkb:P4-ATPase flippase complex alpha subunit ATP8B4(gene name synonym)|uniprotkb:ATP8B4(gene name)|psi-mi:ATP8B4(display_short)|uniprotkb:KIAA1939(gene name synonym)|uniprotkb:ATPase class I type 8B member 4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bryde et al. (2010)	pubmed:20961850|imex:IM-28476	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26441657|imex:IM-28476-25	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001137430.1|refseq:NP_060717.1|ensembl:ENSG00000112697(gene)|ensembl:ENST00000230461(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006855"(xenobiotic transmembrane transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015247"(aminophospholipid flippase activity)|go:"GO:0015917"(aminophospholipid transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0036010"(protein localization to endosome)|go:"GO:0045332"(phospholipid translocation)|go:"GO:0061092"(positive regulation of phospholipid translocation)|go:"GO:0070863"(positive regulation of protein exit from endoplasmic reticulum)|go:"GO:1990531"(phospholipid-translocating ATPase complex)|interpro:IPR005045(Protein of unknown function DUF284, transmembrane eukaryotic)|interpro:IPR030351|mint:Q9NV96|rcsb pdb:6K7G|rcsb pdb:6K7H|rcsb pdb:6K7I|rcsb pdb:6K7J|rcsb pdb:6K7K|rcsb pdb:6K7M|rcsb pdb:6K7N|rcsb pdb:6LKN|rcsb pdb:7BSP|rcsb pdb:7BSQ|rcsb pdb:7BSS|rcsb pdb:7BSU|rcsb pdb:7BSV|rcsb pdb:7BSW|reactome:R-HSA-6798695|rcsb pdb:6K7L	refseq:XP_016878081.1|refseq:NP_079113.2|interpro:IPR006539(Phospholipid-translocating P-type ATPase, flippase)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023298|interpro:IPR023299|interpro:IPR030348|interpro:IPR032630|interpro:IPR032631|interpro:IPR036412|interpro:IPR044492|reactome:R-HSA-6798695|reactome:R-HSA-936837|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|ensembl:ENSG00000104043(gene)|ensembl:ENST00000284509(transcript)|ensembl:ENST00000559829(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007030"(Golgi organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0045332"(phospholipid translocation)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0140326"(ATPase-coupled intramembrane lipid transporter activity)	-	-	-	figure legend:Fig. 3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2020/11/02	2020/11/03	rogid:HTSM+3ihZsx2qIRiNhutEb/Kyu09606	rogid:p2oNvE1dnA+/mAD6cF/FREbZjAk9606	rigid:GNt0RJ8ppR6QZz5FO9bEClHGYzE	false	v5 tag:c-c	his tag:c-c|ha tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q3MIR4	uniprotkb:Q8TF62	intact:EBI-9527107|uniprotkb:B3KR84|uniprotkb:Q14D00|ensembl:ENSP00000450842	intact:EBI-9527207|uniprotkb:Q9H727|ensembl:ENSP00000284509|ensembl:ENSP00000453169	psi-mi:cc50b_human(display_long)|uniprotkb:P4-ATPase flippase complex beta subunit TMEM30B(gene name synonym)|uniprotkb:TMEM30B(gene name)|psi-mi:TMEM30B(display_short)|uniprotkb:CDC50B(gene name synonym)|uniprotkb:Transmembrane protein 30B(gene name synonym)	psi-mi:at8b4_human(display_long)|uniprotkb:P4-ATPase flippase complex alpha subunit ATP8B4(gene name synonym)|uniprotkb:ATP8B4(gene name)|psi-mi:ATP8B4(display_short)|uniprotkb:KIAA1939(gene name synonym)|uniprotkb:ATPase class I type 8B member 4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bryde et al. (2010)	pubmed:20961850|imex:IM-28476	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26441667|imex:IM-28476-27	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001017970.1|ensembl:ENSG00000182107(gene)|ensembl:ENST00000555868(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0015247"(aminophospholipid flippase activity)|go:"GO:0015917"(aminophospholipid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0045332"(phospholipid translocation)|go:"GO:0070863"(positive regulation of protein exit from endoplasmic reticulum)|interpro:IPR005045(Protein of unknown function DUF284, transmembrane eukaryotic)|interpro:IPR030352	refseq:XP_016878081.1|refseq:NP_079113.2|interpro:IPR006539(Phospholipid-translocating P-type ATPase, flippase)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023298|interpro:IPR023299|interpro:IPR030348|interpro:IPR032630|interpro:IPR032631|interpro:IPR036412|interpro:IPR044492|reactome:R-HSA-6798695|reactome:R-HSA-936837|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|ensembl:ENSG00000104043(gene)|ensembl:ENST00000284509(transcript)|ensembl:ENST00000559829(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007030"(Golgi organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0045332"(phospholipid translocation)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0140326"(ATPase-coupled intramembrane lipid transporter activity)	-	-	-	figure legend:Fig. 3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2020/11/02	2020/11/03	rogid:SEW0dE9gp2d2piEq/37EFUxcNOI9606	rogid:p2oNvE1dnA+/mAD6cF/FREbZjAk9606	rigid:iLZwxLaeu8TSbmOi/6FCtJsZOfU	false	v5 tag:c-c	his tag:c-c|ha tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9NV96	uniprotkb:Q9Y2Q0	intact:EBI-2836942|uniprotkb:A8K9V8|uniprotkb:Q96H09|uniprotkb:Q9NSL9|uniprotkb:Q658Z3|uniprotkb:E1P539|ensembl:ENSP00000230461	intact:EBI-9539324|uniprotkb:Q32M35|uniprotkb:Q32M36|uniprotkb:Q4W5J7|uniprotkb:Q4W5P2|ensembl:ENSP00000371084	psi-mi:cc50a_human(display_long)|uniprotkb:TMEM30A(gene name)|psi-mi:TMEM30A(display_short)|uniprotkb:C6orf67(gene name synonym)|uniprotkb:CDC50A(gene name synonym)|uniprotkb:Transmembrane protein 30A(gene name synonym)|uniprotkb:P4-ATPase flippase complex beta subunit TMEM30A(gene name synonym)	psi-mi:at8a1_human(display_long)|uniprotkb:ATP8A1(gene name)|psi-mi:ATP8A1(display_short)|uniprotkb:ATPIA(gene name synonym)|uniprotkb:ATPase class I type 8A member 1(gene name synonym)|uniprotkb:Chromaffin granule ATPase II(gene name synonym)|uniprotkb:P4-ATPase flippase complex alpha subunit ATP8A1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bryde et al. (2010)	pubmed:20961850|imex:IM-28476	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26441677|imex:IM-28476-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001137430.1|refseq:NP_060717.1|ensembl:ENSG00000112697(gene)|ensembl:ENST00000230461(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006855"(xenobiotic transmembrane transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015247"(aminophospholipid flippase activity)|go:"GO:0015917"(aminophospholipid transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0036010"(protein localization to endosome)|go:"GO:0045332"(phospholipid translocation)|go:"GO:0061092"(positive regulation of phospholipid translocation)|go:"GO:0070863"(positive regulation of protein exit from endoplasmic reticulum)|go:"GO:1990531"(phospholipid-translocating ATPase complex)|interpro:IPR005045(Protein of unknown function DUF284, transmembrane eukaryotic)|interpro:IPR030351|mint:Q9NV96|rcsb pdb:6K7G|rcsb pdb:6K7H|rcsb pdb:6K7I|rcsb pdb:6K7J|rcsb pdb:6K7K|rcsb pdb:6K7M|rcsb pdb:6K7N|rcsb pdb:6LKN|rcsb pdb:7BSP|rcsb pdb:7BSQ|rcsb pdb:7BSS|rcsb pdb:7BSU|rcsb pdb:7BSV|rcsb pdb:7BSW|reactome:R-HSA-6798695|rcsb pdb:6K7L	refseq:NP_001098999.1|refseq:NP_006086.1|refseq:XP_016863134.1|ensembl:ENSG00000124406(gene)|ensembl:ENST00000381668(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007612"(learning)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031090"(organelle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042584"(chromaffin granule membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045332"(phospholipid translocation)|go:"GO:0061092"(positive regulation of phospholipid translocation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0140326"(ATPase-coupled intramembrane lipid transporter activity)|go:"GO:0140331"(aminophospholipid translocation)|go:"GO:0140346"(phosphatidylserine flippase activity)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1990531"(phospholipid-translocating ATPase complex)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR006539(Phospholipid-translocating P-type ATPase, flippase)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|interpro:IPR032630|interpro:IPR032631|interpro:IPR036412|interpro:IPR044492|rcsb pdb:6K7G|rcsb pdb:6K7H|rcsb pdb:6K7I|rcsb pdb:6K7J|rcsb pdb:6K7K|rcsb pdb:6K7L|rcsb pdb:6K7M|rcsb pdb:6K7N|reactome:R-HSA-6798695|reactome:R-HSA-936837|go:"GO:0005783"(endoplasmic reticulum)	-	-	-	figure legend:Fig. 3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2020/11/02	2020/11/03	rogid:HTSM+3ihZsx2qIRiNhutEb/Kyu09606	rogid:dgEEryBicD80N5Kh567D+KQDV5g9606	rigid:zMEkJn/3TvvyLf2+SHBevulmzXg	false	v5 tag:c-c	his tag:c-c|ha tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q3MIR4	uniprotkb:Q9Y2Q0	intact:EBI-9527107|uniprotkb:B3KR84|uniprotkb:Q14D00|ensembl:ENSP00000450842	intact:EBI-9539324|uniprotkb:Q32M35|uniprotkb:Q32M36|uniprotkb:Q4W5J7|uniprotkb:Q4W5P2|ensembl:ENSP00000371084	psi-mi:cc50b_human(display_long)|uniprotkb:P4-ATPase flippase complex beta subunit TMEM30B(gene name synonym)|uniprotkb:TMEM30B(gene name)|psi-mi:TMEM30B(display_short)|uniprotkb:CDC50B(gene name synonym)|uniprotkb:Transmembrane protein 30B(gene name synonym)	psi-mi:at8a1_human(display_long)|uniprotkb:ATP8A1(gene name)|psi-mi:ATP8A1(display_short)|uniprotkb:ATPIA(gene name synonym)|uniprotkb:ATPase class I type 8A member 1(gene name synonym)|uniprotkb:Chromaffin granule ATPase II(gene name synonym)|uniprotkb:P4-ATPase flippase complex alpha subunit ATP8A1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bryde et al. (2010)	pubmed:20961850|imex:IM-28476	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26441687|imex:IM-28476-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001017970.1|ensembl:ENSG00000182107(gene)|ensembl:ENST00000555868(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0015247"(aminophospholipid flippase activity)|go:"GO:0015917"(aminophospholipid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0045332"(phospholipid translocation)|go:"GO:0070863"(positive regulation of protein exit from endoplasmic reticulum)|interpro:IPR005045(Protein of unknown function DUF284, transmembrane eukaryotic)|interpro:IPR030352	refseq:NP_001098999.1|refseq:NP_006086.1|refseq:XP_016863134.1|ensembl:ENSG00000124406(gene)|ensembl:ENST00000381668(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007612"(learning)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031090"(organelle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042584"(chromaffin granule membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045332"(phospholipid translocation)|go:"GO:0061092"(positive regulation of phospholipid translocation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0140326"(ATPase-coupled intramembrane lipid transporter activity)|go:"GO:0140331"(aminophospholipid translocation)|go:"GO:0140346"(phosphatidylserine flippase activity)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1990531"(phospholipid-translocating ATPase complex)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR006539(Phospholipid-translocating P-type ATPase, flippase)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|interpro:IPR032630|interpro:IPR032631|interpro:IPR036412|interpro:IPR044492|rcsb pdb:6K7G|rcsb pdb:6K7H|rcsb pdb:6K7I|rcsb pdb:6K7J|rcsb pdb:6K7K|rcsb pdb:6K7L|rcsb pdb:6K7M|rcsb pdb:6K7N|reactome:R-HSA-6798695|reactome:R-HSA-936837|go:"GO:0005783"(endoplasmic reticulum)	-	-	-	figure legend:Fig. 3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2020/11/02	2020/11/03	rogid:SEW0dE9gp2d2piEq/37EFUxcNOI9606	rogid:dgEEryBicD80N5Kh567D+KQDV5g9606	rigid:Z00RojBGOgB5efpjYH7PidXrYoU	false	v5 tag:c-c	his tag:c-c|ha tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9NV96	uniprotkb:P98198	intact:EBI-2836942|uniprotkb:A8K9V8|uniprotkb:Q96H09|uniprotkb:Q9NSL9|uniprotkb:Q658Z3|uniprotkb:E1P539|ensembl:ENSP00000230461	intact:EBI-9539266|uniprotkb:B4E3P4|uniprotkb:Q6NT69|uniprotkb:Q7Z486|uniprotkb:Q96I43|uniprotkb:Q96NQ7	psi-mi:cc50a_human(display_long)|uniprotkb:TMEM30A(gene name)|psi-mi:TMEM30A(display_short)|uniprotkb:C6orf67(gene name synonym)|uniprotkb:CDC50A(gene name synonym)|uniprotkb:Transmembrane protein 30A(gene name synonym)|uniprotkb:P4-ATPase flippase complex beta subunit TMEM30A(gene name synonym)	psi-mi:at8b2_human(display_long)|uniprotkb:ATP8B2(gene name)|psi-mi:ATP8B2(display_short)|uniprotkb:ATPID(gene name synonym)|uniprotkb:KIAA1137(gene name synonym)|uniprotkb:ATPase class I type 8B member 2(gene name synonym)|uniprotkb:P4-ATPase flippase complex alpha subunit ATP8B2(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Bryde et al. (2010)	pubmed:20961850|imex:IM-28476	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26441753|imex:IM-28476-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001137430.1|refseq:NP_060717.1|ensembl:ENSG00000112697(gene)|ensembl:ENST00000230461(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006855"(xenobiotic transmembrane transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015247"(aminophospholipid flippase activity)|go:"GO:0015917"(aminophospholipid transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0036010"(protein localization to endosome)|go:"GO:0045332"(phospholipid translocation)|go:"GO:0061092"(positive regulation of phospholipid translocation)|go:"GO:0070863"(positive regulation of protein exit from endoplasmic reticulum)|go:"GO:1990531"(phospholipid-translocating ATPase complex)|interpro:IPR005045(Protein of unknown function DUF284, transmembrane eukaryotic)|interpro:IPR030351|mint:Q9NV96|rcsb pdb:6K7G|rcsb pdb:6K7H|rcsb pdb:6K7I|rcsb pdb:6K7J|rcsb pdb:6K7K|rcsb pdb:6K7M|rcsb pdb:6K7N|rcsb pdb:6LKN|rcsb pdb:7BSP|rcsb pdb:7BSQ|rcsb pdb:7BSS|rcsb pdb:7BSU|rcsb pdb:7BSV|rcsb pdb:7BSW|reactome:R-HSA-6798695|rcsb pdb:6K7L	interpro:IPR023214|interpro:IPR030347|reactome:R-HSA-936837|interpro:IPR032630|interpro:IPR032631|interpro:IPR044492|interpro:IPR023299|interpro:IPR018303|interpro:IPR006539(Phospholipid-translocating P-type ATPase, flippase)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|refseq:NP_001005855.1|refseq:NP_065185.1|refseq:XP_005245412.1|interpro:IPR023298|go:"GO:0000287"(magnesium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007030"(Golgi organization)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0045332"(phospholipid translocation)|go:"GO:0140326"(ATPase-coupled intramembrane lipid transporter activity)|go:"GO:0140345"(phosphatidylcholine flippase activity)|interpro:IPR036412	go:"GO:0005886"(plasma membrane)	-	-	figure legend:Fig. 4B, 5C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10029(crigr-cho_ups1)|taxid:10029(Cricetulus griseus CHO-derived UPS-1 mutant cells defective in nonendo- cytic uptake of NBD-PS)	-	2020/11/02	2020/11/03	rogid:HTSM+3ihZsx2qIRiNhutEb/Kyu09606	rogid:0qfmiw+yRBCQbBg9vx2Wzsmy53Y9606	rigid:SjmygEkeYryN4j6DniVzbCkHwuk	false	v5 tag:c-c	red fluorescent protein tag:c-c|ha tag:c-c|mutation decreasing interaction strength:411-411	-	-	psi-mi:"MI:1201"(anti-tag immunocytochemistry)	psi-mi:"MI:1201"(anti-tag immunocytochemistry)
uniprotkb:Q9NV96	uniprotkb:Q8TF62	intact:EBI-2836942|uniprotkb:A8K9V8|uniprotkb:Q96H09|uniprotkb:Q9NSL9|uniprotkb:Q658Z3|uniprotkb:E1P539|ensembl:ENSP00000230461	intact:EBI-9527207|uniprotkb:Q9H727|ensembl:ENSP00000284509|ensembl:ENSP00000453169	psi-mi:cc50a_human(display_long)|uniprotkb:TMEM30A(gene name)|psi-mi:TMEM30A(display_short)|uniprotkb:C6orf67(gene name synonym)|uniprotkb:CDC50A(gene name synonym)|uniprotkb:Transmembrane protein 30A(gene name synonym)|uniprotkb:P4-ATPase flippase complex beta subunit TMEM30A(gene name synonym)	psi-mi:at8b4_human(display_long)|uniprotkb:P4-ATPase flippase complex alpha subunit ATP8B4(gene name synonym)|uniprotkb:ATP8B4(gene name)|psi-mi:ATP8B4(display_short)|uniprotkb:KIAA1939(gene name synonym)|uniprotkb:ATPase class I type 8B member 4(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Bryde et al. (2010)	pubmed:20961850|imex:IM-28476	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26441703|imex:IM-28476-29	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001137430.1|refseq:NP_060717.1|ensembl:ENSG00000112697(gene)|ensembl:ENST00000230461(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006855"(xenobiotic transmembrane transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015247"(aminophospholipid flippase activity)|go:"GO:0015917"(aminophospholipid transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0036010"(protein localization to endosome)|go:"GO:0045332"(phospholipid translocation)|go:"GO:0061092"(positive regulation of phospholipid translocation)|go:"GO:0070863"(positive regulation of protein exit from endoplasmic reticulum)|go:"GO:1990531"(phospholipid-translocating ATPase complex)|interpro:IPR005045(Protein of unknown function DUF284, transmembrane eukaryotic)|interpro:IPR030351|mint:Q9NV96|rcsb pdb:6K7G|rcsb pdb:6K7H|rcsb pdb:6K7I|rcsb pdb:6K7J|rcsb pdb:6K7K|rcsb pdb:6K7M|rcsb pdb:6K7N|rcsb pdb:6LKN|rcsb pdb:7BSP|rcsb pdb:7BSQ|rcsb pdb:7BSS|rcsb pdb:7BSU|rcsb pdb:7BSV|rcsb pdb:7BSW|reactome:R-HSA-6798695|rcsb pdb:6K7L	refseq:XP_016878081.1|refseq:NP_079113.2|interpro:IPR006539(Phospholipid-translocating P-type ATPase, flippase)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023298|interpro:IPR023299|interpro:IPR030348|interpro:IPR032630|interpro:IPR032631|interpro:IPR036412|interpro:IPR044492|reactome:R-HSA-6798695|reactome:R-HSA-936837|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|ensembl:ENSG00000104043(gene)|ensembl:ENST00000284509(transcript)|ensembl:ENST00000559829(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007030"(Golgi organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0045332"(phospholipid translocation)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0140326"(ATPase-coupled intramembrane lipid transporter activity)	go:"GO:0005886"(plasma membrane)	-	-	figure legend:Fig. 4C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10029(crigr-cho_ups1)|taxid:10029(Cricetulus griseus CHO-derived UPS-1 mutant cells defective in nonendo- cytic uptake of NBD-PS)	-	2020/11/02	2020/11/03	rogid:HTSM+3ihZsx2qIRiNhutEb/Kyu09606	rogid:p2oNvE1dnA+/mAD6cF/FREbZjAk9606	rigid:GNt0RJ8ppR6QZz5FO9bEClHGYzE	false	v5 tag:c-c	his tag:c-c|red fluorescent protein tag:c-c	-	-	psi-mi:"MI:1201"(anti-tag immunocytochemistry)	psi-mi:"MI:1201"(anti-tag immunocytochemistry)
uniprotkb:Q9NV96	uniprotkb:O43520	intact:EBI-2836942|uniprotkb:A8K9V8|uniprotkb:Q96H09|uniprotkb:Q9NSL9|uniprotkb:Q658Z3|uniprotkb:E1P539|ensembl:ENSP00000230461	intact:EBI-9524729|uniprotkb:Q9BTP8|intact:EBI-28976955|ensembl:ENSP00000497896	psi-mi:cc50a_human(display_long)|uniprotkb:TMEM30A(gene name)|psi-mi:TMEM30A(display_short)|uniprotkb:C6orf67(gene name synonym)|uniprotkb:CDC50A(gene name synonym)|uniprotkb:Transmembrane protein 30A(gene name synonym)|uniprotkb:P4-ATPase flippase complex beta subunit TMEM30A(gene name synonym)	psi-mi:at8b1_human(display_long)|uniprotkb:P4-ATPase flippase complex alpha subunit ATP8B1(gene name synonym)|uniprotkb:ATP8B1(gene name)|psi-mi:ATP8B1(display_short)|uniprotkb:ATPIC(gene name synonym)|uniprotkb:FIC1(gene name synonym)|uniprotkb:PFIC(gene name synonym)|uniprotkb:ATPase class I type 8B member 1(gene name synonym)|uniprotkb:Familial intrahepatic cholestasis type 1(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Bryde et al. (2010)	pubmed:20961850|imex:IM-28476	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26441743|imex:IM-28476-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001137430.1|refseq:NP_060717.1|ensembl:ENSG00000112697(gene)|ensembl:ENST00000230461(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006855"(xenobiotic transmembrane transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015247"(aminophospholipid flippase activity)|go:"GO:0015917"(aminophospholipid transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0036010"(protein localization to endosome)|go:"GO:0045332"(phospholipid translocation)|go:"GO:0061092"(positive regulation of phospholipid translocation)|go:"GO:0070863"(positive regulation of protein exit from endoplasmic reticulum)|go:"GO:1990531"(phospholipid-translocating ATPase complex)|interpro:IPR005045(Protein of unknown function DUF284, transmembrane eukaryotic)|interpro:IPR030351|mint:Q9NV96|rcsb pdb:6K7G|rcsb pdb:6K7H|rcsb pdb:6K7I|rcsb pdb:6K7J|rcsb pdb:6K7K|rcsb pdb:6K7M|rcsb pdb:6K7N|rcsb pdb:6LKN|rcsb pdb:7BSP|rcsb pdb:7BSQ|rcsb pdb:7BSS|rcsb pdb:7BSU|rcsb pdb:7BSV|rcsb pdb:7BSW|reactome:R-HSA-6798695|rcsb pdb:6K7L	ensembl:ENSP00000497896|refseq:XP_011524324.1|refseq:XP_006722544.1|refseq:NP_005594.1|ensembl:ENSG00000081923(gene)|ensembl:ENST00000648908(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006855"(xenobiotic transmembrane transport)|go:"GO:0007030"(Golgi organization)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008206"(bile acid metabolic process)|go:"GO:0015721"(bile acid and bile salt transport)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0021650"(vestibulocochlear nerve formation)|go:"GO:0031526"(brush border membrane)|go:"GO:0032420"(stereocilium)|go:"GO:0032534"(regulation of microvillus assembly)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0045176"(apical protein localization)|go:"GO:0045332"(phospholipid translocation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0060119"(inner ear receptor cell development)|go:"GO:0140326"(ATPase-coupled intramembrane lipid transporter activity)|go:"GO:0140345"(phosphatidylcholine flippase activity)|go:"GO:0140346"(phosphatidylserine flippase activity)|go:"GO:1901612"(cardiolipin binding)|go:"GO:1903729"(regulation of plasma membrane organization)|go:"GO:1990531"(phospholipid-translocating ATPase complex)|go:"GO:2001225"(regulation of chloride transport)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR006539(Phospholipid-translocating P-type ATPase, flippase)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023298|interpro:IPR023299|interpro:IPR030346|interpro:IPR032630|interpro:IPR032631|interpro:IPR036412|interpro:IPR044492|reactome:R-HSA-936837	go:"GO:0005886"(plasma membrane)	-	-	figure legend:Fig. 4A, 5A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10029(crigr-cho_ups1)|taxid:10029(Cricetulus griseus CHO-derived UPS-1 mutant cells defective in nonendo- cytic uptake of NBD-PS)	-	2020/11/02	2020/11/03	rogid:HTSM+3ihZsx2qIRiNhutEb/Kyu09606	rogid:etMCmFj6oGhBGan/RrxU5eUdWCM9606	rigid:2yvSqj7gC2sM/lIgVP3rtz0JSjg	false	v5 tag:c-c	ha tag:c-c|red fluorescent protein tag:c-c|mutation decreasing interaction strength:454-454	-	-	psi-mi:"MI:1201"(anti-tag immunocytochemistry)	psi-mi:"MI:1201"(anti-tag immunocytochemistry)
uniprotkb:Q9NV96	uniprotkb:Q9Y2Q0	intact:EBI-2836942|uniprotkb:A8K9V8|uniprotkb:Q96H09|uniprotkb:Q9NSL9|uniprotkb:Q658Z3|uniprotkb:E1P539|ensembl:ENSP00000230461	intact:EBI-9539324|uniprotkb:Q32M35|uniprotkb:Q32M36|uniprotkb:Q4W5J7|uniprotkb:Q4W5P2|ensembl:ENSP00000371084	psi-mi:cc50a_human(display_long)|uniprotkb:TMEM30A(gene name)|psi-mi:TMEM30A(display_short)|uniprotkb:C6orf67(gene name synonym)|uniprotkb:CDC50A(gene name synonym)|uniprotkb:Transmembrane protein 30A(gene name synonym)|uniprotkb:P4-ATPase flippase complex beta subunit TMEM30A(gene name synonym)	psi-mi:at8a1_human(display_long)|uniprotkb:ATP8A1(gene name)|psi-mi:ATP8A1(display_short)|uniprotkb:ATPIA(gene name synonym)|uniprotkb:ATPase class I type 8A member 1(gene name synonym)|uniprotkb:Chromaffin granule ATPase II(gene name synonym)|uniprotkb:P4-ATPase flippase complex alpha subunit ATP8A1(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Bryde et al. (2010)	pubmed:20961850|imex:IM-28476	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26441723|imex:IM-28476-31	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001137430.1|refseq:NP_060717.1|ensembl:ENSG00000112697(gene)|ensembl:ENST00000230461(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006855"(xenobiotic transmembrane transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015247"(aminophospholipid flippase activity)|go:"GO:0015917"(aminophospholipid transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0036010"(protein localization to endosome)|go:"GO:0045332"(phospholipid translocation)|go:"GO:0061092"(positive regulation of phospholipid translocation)|go:"GO:0070863"(positive regulation of protein exit from endoplasmic reticulum)|go:"GO:1990531"(phospholipid-translocating ATPase complex)|interpro:IPR005045(Protein of unknown function DUF284, transmembrane eukaryotic)|interpro:IPR030351|mint:Q9NV96|rcsb pdb:6K7G|rcsb pdb:6K7H|rcsb pdb:6K7I|rcsb pdb:6K7J|rcsb pdb:6K7K|rcsb pdb:6K7M|rcsb pdb:6K7N|rcsb pdb:6LKN|rcsb pdb:7BSP|rcsb pdb:7BSQ|rcsb pdb:7BSS|rcsb pdb:7BSU|rcsb pdb:7BSV|rcsb pdb:7BSW|reactome:R-HSA-6798695|rcsb pdb:6K7L	refseq:NP_001098999.1|refseq:NP_006086.1|refseq:XP_016863134.1|ensembl:ENSG00000124406(gene)|ensembl:ENST00000381668(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007612"(learning)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031090"(organelle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042584"(chromaffin granule membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045332"(phospholipid translocation)|go:"GO:0061092"(positive regulation of phospholipid translocation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0140326"(ATPase-coupled intramembrane lipid transporter activity)|go:"GO:0140331"(aminophospholipid translocation)|go:"GO:0140346"(phosphatidylserine flippase activity)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1990531"(phospholipid-translocating ATPase complex)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR006539(Phospholipid-translocating P-type ATPase, flippase)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|interpro:IPR032630|interpro:IPR032631|interpro:IPR036412|interpro:IPR044492|rcsb pdb:6K7G|rcsb pdb:6K7H|rcsb pdb:6K7I|rcsb pdb:6K7J|rcsb pdb:6K7K|rcsb pdb:6K7L|rcsb pdb:6K7M|rcsb pdb:6K7N|reactome:R-HSA-6798695|reactome:R-HSA-936837|go:"GO:0005783"(endoplasmic reticulum)	go:"GO:0005886"(plasma membrane)	-	-	figure legend:Fig. 4D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10029(crigr-cho_ups1)|taxid:10029(Cricetulus griseus CHO-derived UPS-1 mutant cells defective in nonendo- cytic uptake of NBD-PS)	-	2020/11/02	2020/11/03	rogid:HTSM+3ihZsx2qIRiNhutEb/Kyu09606	rogid:dgEEryBicD80N5Kh567D+KQDV5g9606	rigid:zMEkJn/3TvvyLf2+SHBevulmzXg	false	v5 tag:c-c	ha tag:c-c|red fluorescent protein tag:c-c	-	-	psi-mi:"MI:1201"(anti-tag immunocytochemistry)	psi-mi:"MI:1201"(anti-tag immunocytochemistry)
uniprotkb:Q3MIR4	uniprotkb:O43520	intact:EBI-9527107|uniprotkb:B3KR84|uniprotkb:Q14D00|ensembl:ENSP00000450842	intact:EBI-9524729|uniprotkb:Q9BTP8|intact:EBI-28976955|ensembl:ENSP00000497896	psi-mi:cc50b_human(display_long)|uniprotkb:P4-ATPase flippase complex beta subunit TMEM30B(gene name synonym)|uniprotkb:TMEM30B(gene name)|psi-mi:TMEM30B(display_short)|uniprotkb:CDC50B(gene name synonym)|uniprotkb:Transmembrane protein 30B(gene name synonym)	psi-mi:at8b1_human(display_long)|uniprotkb:P4-ATPase flippase complex alpha subunit ATP8B1(gene name synonym)|uniprotkb:ATP8B1(gene name)|psi-mi:ATP8B1(display_short)|uniprotkb:ATPIC(gene name synonym)|uniprotkb:FIC1(gene name synonym)|uniprotkb:PFIC(gene name synonym)|uniprotkb:ATPase class I type 8B member 1(gene name synonym)|uniprotkb:Familial intrahepatic cholestasis type 1(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Bryde et al. (2010)	pubmed:20961850|imex:IM-28476	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26441773|imex:IM-28476-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001017970.1|ensembl:ENSG00000182107(gene)|ensembl:ENST00000555868(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0015247"(aminophospholipid flippase activity)|go:"GO:0015917"(aminophospholipid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0045332"(phospholipid translocation)|go:"GO:0070863"(positive regulation of protein exit from endoplasmic reticulum)|interpro:IPR005045(Protein of unknown function DUF284, transmembrane eukaryotic)|interpro:IPR030352	ensembl:ENSP00000497896|refseq:XP_011524324.1|refseq:XP_006722544.1|refseq:NP_005594.1|ensembl:ENSG00000081923(gene)|ensembl:ENST00000648908(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006855"(xenobiotic transmembrane transport)|go:"GO:0007030"(Golgi organization)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008206"(bile acid metabolic process)|go:"GO:0015721"(bile acid and bile salt transport)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0021650"(vestibulocochlear nerve formation)|go:"GO:0031526"(brush border membrane)|go:"GO:0032420"(stereocilium)|go:"GO:0032534"(regulation of microvillus assembly)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0045176"(apical protein localization)|go:"GO:0045332"(phospholipid translocation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0060119"(inner ear receptor cell development)|go:"GO:0140326"(ATPase-coupled intramembrane lipid transporter activity)|go:"GO:0140345"(phosphatidylcholine flippase activity)|go:"GO:0140346"(phosphatidylserine flippase activity)|go:"GO:1901612"(cardiolipin binding)|go:"GO:1903729"(regulation of plasma membrane organization)|go:"GO:1990531"(phospholipid-translocating ATPase complex)|go:"GO:2001225"(regulation of chloride transport)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR006539(Phospholipid-translocating P-type ATPase, flippase)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023298|interpro:IPR023299|interpro:IPR030346|interpro:IPR032630|interpro:IPR032631|interpro:IPR036412|interpro:IPR044492|reactome:R-HSA-936837	go:"GO:0005886"(plasma membrane)	-	-	figure legend:Fig. 4A, 5A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10029(crigr-cho_ups1)|taxid:10029(Cricetulus griseus CHO-derived UPS-1 mutant cells defective in nonendo- cytic uptake of NBD-PS)	-	2020/11/02	2020/11/03	rogid:SEW0dE9gp2d2piEq/37EFUxcNOI9606	rogid:etMCmFj6oGhBGan/RrxU5eUdWCM9606	rigid:GTGeuI97aNQ1cwMsV2WSwS8/TiU	false	v5 tag:c-c	ha tag:c-c|red fluorescent protein tag:c-c|mutation decreasing interaction strength:454-454	-	-	psi-mi:"MI:1201"(anti-tag immunocytochemistry)	psi-mi:"MI:1201"(anti-tag immunocytochemistry)
uniprotkb:Q3MIR4	uniprotkb:Q8TF62	intact:EBI-9527107|uniprotkb:B3KR84|uniprotkb:Q14D00|ensembl:ENSP00000450842	intact:EBI-9527207|uniprotkb:Q9H727|ensembl:ENSP00000284509|ensembl:ENSP00000453169	psi-mi:cc50b_human(display_long)|uniprotkb:P4-ATPase flippase complex beta subunit TMEM30B(gene name synonym)|uniprotkb:TMEM30B(gene name)|psi-mi:TMEM30B(display_short)|uniprotkb:CDC50B(gene name synonym)|uniprotkb:Transmembrane protein 30B(gene name synonym)	psi-mi:at8b4_human(display_long)|uniprotkb:P4-ATPase flippase complex alpha subunit ATP8B4(gene name synonym)|uniprotkb:ATP8B4(gene name)|psi-mi:ATP8B4(display_short)|uniprotkb:KIAA1939(gene name synonym)|uniprotkb:ATPase class I type 8B member 4(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Bryde et al. (2010)	pubmed:20961850|imex:IM-28476	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26441713|imex:IM-28476-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001017970.1|ensembl:ENSG00000182107(gene)|ensembl:ENST00000555868(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0015247"(aminophospholipid flippase activity)|go:"GO:0015917"(aminophospholipid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0045332"(phospholipid translocation)|go:"GO:0070863"(positive regulation of protein exit from endoplasmic reticulum)|interpro:IPR005045(Protein of unknown function DUF284, transmembrane eukaryotic)|interpro:IPR030352	refseq:XP_016878081.1|refseq:NP_079113.2|interpro:IPR006539(Phospholipid-translocating P-type ATPase, flippase)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023298|interpro:IPR023299|interpro:IPR030348|interpro:IPR032630|interpro:IPR032631|interpro:IPR036412|interpro:IPR044492|reactome:R-HSA-6798695|reactome:R-HSA-936837|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|ensembl:ENSG00000104043(gene)|ensembl:ENST00000284509(transcript)|ensembl:ENST00000559829(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007030"(Golgi organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0045332"(phospholipid translocation)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0140326"(ATPase-coupled intramembrane lipid transporter activity)	go:"GO:0005886"(plasma membrane)	-	-	figure legend:Fig. 4C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10029(crigr-cho_ups1)|taxid:10029(Cricetulus griseus CHO-derived UPS-1 mutant cells defective in nonendo- cytic uptake of NBD-PS)	-	2020/11/02	2020/11/03	rogid:SEW0dE9gp2d2piEq/37EFUxcNOI9606	rogid:p2oNvE1dnA+/mAD6cF/FREbZjAk9606	rigid:iLZwxLaeu8TSbmOi/6FCtJsZOfU	false	v5 tag:c-c	his tag:c-c|ha tag:c-c	-	-	psi-mi:"MI:1201"(anti-tag immunocytochemistry)	psi-mi:"MI:1201"(anti-tag immunocytochemistry)
uniprotkb:Q3MIR4	uniprotkb:Q9Y2Q0	intact:EBI-9527107|uniprotkb:B3KR84|uniprotkb:Q14D00|ensembl:ENSP00000450842	intact:EBI-9539324|uniprotkb:Q32M35|uniprotkb:Q32M36|uniprotkb:Q4W5J7|uniprotkb:Q4W5P2|ensembl:ENSP00000371084	psi-mi:cc50b_human(display_long)|uniprotkb:P4-ATPase flippase complex beta subunit TMEM30B(gene name synonym)|uniprotkb:TMEM30B(gene name)|psi-mi:TMEM30B(display_short)|uniprotkb:CDC50B(gene name synonym)|uniprotkb:Transmembrane protein 30B(gene name synonym)	psi-mi:at8a1_human(display_long)|uniprotkb:ATP8A1(gene name)|psi-mi:ATP8A1(display_short)|uniprotkb:ATPIA(gene name synonym)|uniprotkb:ATPase class I type 8A member 1(gene name synonym)|uniprotkb:Chromaffin granule ATPase II(gene name synonym)|uniprotkb:P4-ATPase flippase complex alpha subunit ATP8A1(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Bryde et al. (2010)	pubmed:20961850|imex:IM-28476	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26441733|imex:IM-28476-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001017970.1|ensembl:ENSG00000182107(gene)|ensembl:ENST00000555868(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0015247"(aminophospholipid flippase activity)|go:"GO:0015917"(aminophospholipid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0045332"(phospholipid translocation)|go:"GO:0070863"(positive regulation of protein exit from endoplasmic reticulum)|interpro:IPR005045(Protein of unknown function DUF284, transmembrane eukaryotic)|interpro:IPR030352	refseq:NP_001098999.1|refseq:NP_006086.1|refseq:XP_016863134.1|ensembl:ENSG00000124406(gene)|ensembl:ENST00000381668(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007612"(learning)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031090"(organelle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042584"(chromaffin granule membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045332"(phospholipid translocation)|go:"GO:0061092"(positive regulation of phospholipid translocation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0140326"(ATPase-coupled intramembrane lipid transporter activity)|go:"GO:0140331"(aminophospholipid translocation)|go:"GO:0140346"(phosphatidylserine flippase activity)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1990531"(phospholipid-translocating ATPase complex)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR006539(Phospholipid-translocating P-type ATPase, flippase)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|interpro:IPR032630|interpro:IPR032631|interpro:IPR036412|interpro:IPR044492|rcsb pdb:6K7G|rcsb pdb:6K7H|rcsb pdb:6K7I|rcsb pdb:6K7J|rcsb pdb:6K7K|rcsb pdb:6K7L|rcsb pdb:6K7M|rcsb pdb:6K7N|reactome:R-HSA-6798695|reactome:R-HSA-936837|go:"GO:0005783"(endoplasmic reticulum)	go:"GO:0005886"(plasma membrane)	-	-	figure legend:Fig. 4D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10029(crigr-cho_ups1)|taxid:10029(Cricetulus griseus CHO-derived UPS-1 mutant cells defective in nonendo- cytic uptake of NBD-PS)	-	2020/11/02	2020/11/03	rogid:SEW0dE9gp2d2piEq/37EFUxcNOI9606	rogid:dgEEryBicD80N5Kh567D+KQDV5g9606	rigid:Z00RojBGOgB5efpjYH7PidXrYoU	false	v5 tag:c-c	ha tag:c-c|red fluorescent protein tag:c-c	-	-	psi-mi:"MI:1201"(anti-tag immunocytochemistry)	psi-mi:"MI:1201"(anti-tag immunocytochemistry)
uniprotkb:P98198	uniprotkb:Q3MIR4	intact:EBI-9539266|uniprotkb:B4E3P4|uniprotkb:Q6NT69|uniprotkb:Q7Z486|uniprotkb:Q96I43|uniprotkb:Q96NQ7	intact:EBI-9527107|uniprotkb:B3KR84|uniprotkb:Q14D00|ensembl:ENSP00000450842	psi-mi:at8b2_human(display_long)|uniprotkb:ATP8B2(gene name)|psi-mi:ATP8B2(display_short)|uniprotkb:ATPID(gene name synonym)|uniprotkb:KIAA1137(gene name synonym)|uniprotkb:ATPase class I type 8B member 2(gene name synonym)|uniprotkb:P4-ATPase flippase complex alpha subunit ATP8B2(gene name synonym)	psi-mi:cc50b_human(display_long)|uniprotkb:P4-ATPase flippase complex beta subunit TMEM30B(gene name synonym)|uniprotkb:TMEM30B(gene name)|psi-mi:TMEM30B(display_short)|uniprotkb:CDC50B(gene name synonym)|uniprotkb:Transmembrane protein 30B(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Bryde et al. (2010)	pubmed:20961850|imex:IM-28476	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26441763|imex:IM-28476-33	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR023214|interpro:IPR030347|reactome:R-HSA-936837|interpro:IPR032630|interpro:IPR032631|interpro:IPR044492|interpro:IPR023299|interpro:IPR018303|interpro:IPR006539(Phospholipid-translocating P-type ATPase, flippase)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|refseq:NP_001005855.1|refseq:NP_065185.1|refseq:XP_005245412.1|interpro:IPR023298|go:"GO:0000287"(magnesium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007030"(Golgi organization)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0045332"(phospholipid translocation)|go:"GO:0140326"(ATPase-coupled intramembrane lipid transporter activity)|go:"GO:0140345"(phosphatidylcholine flippase activity)|interpro:IPR036412	refseq:NP_001017970.1|ensembl:ENSG00000182107(gene)|ensembl:ENST00000555868(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0015247"(aminophospholipid flippase activity)|go:"GO:0015917"(aminophospholipid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0045332"(phospholipid translocation)|go:"GO:0070863"(positive regulation of protein exit from endoplasmic reticulum)|interpro:IPR005045(Protein of unknown function DUF284, transmembrane eukaryotic)|interpro:IPR030352	go:"GO:0005886"(plasma membrane)	-	-	figure legend:Fig. 4B, 5C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10029(crigr-cho_ups1)|taxid:10029(Cricetulus griseus CHO-derived UPS-1 mutant cells defective in nonendo- cytic uptake of NBD-PS)	-	2020/11/02	2020/11/03	rogid:0qfmiw+yRBCQbBg9vx2Wzsmy53Y9606	rogid:SEW0dE9gp2d2piEq/37EFUxcNOI9606	rigid:LpwWqSvvYxH0XAlPUGLkdxbN/N0	false	his tag:c-c|ha tag:c-c|mutation with no effect:411-411	v5 tag:c-c	-	-	psi-mi:"MI:1201"(anti-tag immunocytochemistry)	psi-mi:"MI:1201"(anti-tag immunocytochemistry)
uniprotkb:Q9NV96	uniprotkb:O43520	intact:EBI-2836942|uniprotkb:A8K9V8|uniprotkb:Q96H09|uniprotkb:Q9NSL9|uniprotkb:Q658Z3|uniprotkb:E1P539|ensembl:ENSP00000230461	intact:EBI-9524729|uniprotkb:Q9BTP8|intact:EBI-28976955|ensembl:ENSP00000497896	psi-mi:cc50a_human(display_long)|uniprotkb:TMEM30A(gene name)|psi-mi:TMEM30A(display_short)|uniprotkb:C6orf67(gene name synonym)|uniprotkb:CDC50A(gene name synonym)|uniprotkb:Transmembrane protein 30A(gene name synonym)|uniprotkb:P4-ATPase flippase complex beta subunit TMEM30A(gene name synonym)	psi-mi:at8b1_human(display_long)|uniprotkb:P4-ATPase flippase complex alpha subunit ATP8B1(gene name synonym)|uniprotkb:ATP8B1(gene name)|psi-mi:ATP8B1(display_short)|uniprotkb:ATPIC(gene name synonym)|uniprotkb:FIC1(gene name synonym)|uniprotkb:PFIC(gene name synonym)|uniprotkb:ATPase class I type 8B member 1(gene name synonym)|uniprotkb:Familial intrahepatic cholestasis type 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Bryde et al. (2010)	pubmed:20961850|imex:IM-28476	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26441840|imex:IM-28476-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001137430.1|refseq:NP_060717.1|ensembl:ENSG00000112697(gene)|ensembl:ENST00000230461(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006855"(xenobiotic transmembrane transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015247"(aminophospholipid flippase activity)|go:"GO:0015917"(aminophospholipid transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0036010"(protein localization to endosome)|go:"GO:0045332"(phospholipid translocation)|go:"GO:0061092"(positive regulation of phospholipid translocation)|go:"GO:0070863"(positive regulation of protein exit from endoplasmic reticulum)|go:"GO:1990531"(phospholipid-translocating ATPase complex)|interpro:IPR005045(Protein of unknown function DUF284, transmembrane eukaryotic)|interpro:IPR030351|mint:Q9NV96|rcsb pdb:6K7G|rcsb pdb:6K7H|rcsb pdb:6K7I|rcsb pdb:6K7J|rcsb pdb:6K7K|rcsb pdb:6K7M|rcsb pdb:6K7N|rcsb pdb:6LKN|rcsb pdb:7BSP|rcsb pdb:7BSQ|rcsb pdb:7BSS|rcsb pdb:7BSU|rcsb pdb:7BSV|rcsb pdb:7BSW|reactome:R-HSA-6798695|rcsb pdb:6K7L	ensembl:ENSP00000497896|refseq:XP_011524324.1|refseq:XP_006722544.1|refseq:NP_005594.1|ensembl:ENSG00000081923(gene)|ensembl:ENST00000648908(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006855"(xenobiotic transmembrane transport)|go:"GO:0007030"(Golgi organization)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008206"(bile acid metabolic process)|go:"GO:0015721"(bile acid and bile salt transport)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0021650"(vestibulocochlear nerve formation)|go:"GO:0031526"(brush border membrane)|go:"GO:0032420"(stereocilium)|go:"GO:0032534"(regulation of microvillus assembly)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0045176"(apical protein localization)|go:"GO:0045332"(phospholipid translocation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0060119"(inner ear receptor cell development)|go:"GO:0140326"(ATPase-coupled intramembrane lipid transporter activity)|go:"GO:0140345"(phosphatidylcholine flippase activity)|go:"GO:0140346"(phosphatidylserine flippase activity)|go:"GO:1901612"(cardiolipin binding)|go:"GO:1903729"(regulation of plasma membrane organization)|go:"GO:1990531"(phospholipid-translocating ATPase complex)|go:"GO:2001225"(regulation of chloride transport)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR006539(Phospholipid-translocating P-type ATPase, flippase)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023298|interpro:IPR023299|interpro:IPR030346|interpro:IPR032630|interpro:IPR032631|interpro:IPR036412|interpro:IPR044492|reactome:R-HSA-936837	-	-	-	figure legend:Fig. 6A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7108(spofr-sf_9)|taxid:7108(Spodoptera frugiperda insect cells)	-	2020/11/02	2020/11/03	rogid:HTSM+3ihZsx2qIRiNhutEb/Kyu09606	rogid:etMCmFj6oGhBGan/RrxU5eUdWCM9606	rigid:2yvSqj7gC2sM/lIgVP3rtz0JSjg	false	v5 tag:c-c	his tag:c-c|ha tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
intenz:7.6.2.1	-	intact:EBI-26441879|rhea:"RHEA:38567"	-	psi-mi:atp8b1-tmem30a_human(display_short)|psi-mi:7.6.2.1(display_long)|intact:ATP8B1-CDC50A P4-ATPase complex(complex recommended name)|intact:"ATP8B1:TMEM30A"(complex systematic name)|intact:ATP8B1-CDC50A flippase complex(complex synonym)|intact:Class 1b flippase complex(complex synonym)	-	psi-mi:"MI:0841"(phosphotransferase assay)	Bryde et al. (2010)	pubmed:20961850|imex:IM-28476	taxid:9606(human)|taxid:9606(Homo sapiens)	-	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26441856|imex:IM-28476-35	-	-	psi-mi:"MI:0898"(putative self)	-	psi-mi:"MI:0898"(putative self)	-	psi-mi:"MI:1302"(stable complex)	-	efo:"Orphanet:99960"(see-also)|efo:"Orphanet:69665"(see-also)|efo:"Orphanet:79306"(see-also)|go:"GO:0005524"(ATP binding)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:1990531"(phospholipid-translocating ATPase complex)|go:"GO:0005887"(integral component of plasma membrane)|intact:EBI-26441578(exp-evidence)|complex portal:CPX-6282(complex-primary)|evidence ontology:"ECO:0000353"|pubmed:27458383(see-also)|pubmed:20961850(see-also)|go:"GO:0140345"(phosphatidylcholine flippase activity)|pubmed:26567335(see-also)|pubmed:30509129(see-also)|pubmed:25315773(see-also)	-	go:"GO:0046777"(protein autophosphorylation)	curated-complex:"A membrane pump which actively translocates, or flips, phospholipids across cell membranes from the exoplasmic to the cytoplasmic leaflet of the lipid bilayer. This generates and maintains membrane lipid asymmetry, a property essential for a wide variety of cellular processes such as vesicle budding and intracellular vesicle trafficking. Transport is accomplished by cyclic changes between two main enzyme conformations, during which the ATP8B1 ATPase is phosphorylated by ATP at a conserved aspartate residue (Asp-454) and subsequently dephosphorylated. CDC50 proteins are required for transport of P4‐ATPases from the endoplasmic reticulum to their final destinations and may also affect the catalytic cycle of the complex. Preferentially translocates phosphatidylcholine in the plasma membrane."|complex-properties:ATP-dependent phosphorylation induces a large rotational movement of the actuator domain of the ATPase around the phosphorylation site in the phosphorylation domain. This is accompanied by lateral shifts of the first and second transmembrane helices, thereby allowing phospholipid binding. The phospholipid head group passes through the hydrophilic cleft, while the acyl chain is exposed toward the lipid environment.|complex-assembly:Heterodimer|disease:"Cholestasis, progressive familial intrahepatic, 1 (PFIC1) [Orphanet:79306]: A disorder characterized by early onset of cholestasis that progresses to hepatic fibrosis, cirrhosis, and end-stage liver disease before adulthood."|disease:"Cholestasis, benign recurrent intrahepatic, 1 (BRIC1) [Orphanet:99960]: A disorder characterized by intermittent episodes of cholestasis without progression to liver failure. There is initial elevation of serum bile acids, followed by cholestatic jaundice which generally spontaneously resolves after periods of weeks to months. The cholestatic attacks vary in severity and duration. Patients are asymptomatic between episodes, both clinically and biochemically."|disease:"Cholestasis of pregnancy, intrahepatic 1 (ICP1) [Orphanet:69665] A liver disorder of pregnancy. It presents during the second or, more commonly, the third trimester of pregnancy with intense pruritus which becomes more severe with advancing gestation and cholestasis. Cholestasis results from abnormal biliary transport from the liver into the small intestine. ICP1 causes fetal distress, spontaneous premature delivery and intrauterine death. ICP1 patients have spontaneous and progressive disappearance of cholestasis after delivery."	-	figure legend:Fig. 6B-E|inhibition:"Vanadate (CHEBI:46442)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/11/02	2020/11/04	-	-	-	false	ha tag:c-c|his tag:c-c|v5 tag:c-c|mutation disrupting interaction rate:454-454	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	-