#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P37146	uniprotkb:P37146	intact:EBI-1121841|uniprotkb:P78244|ensemblbacteria:AAC75723|ensemblbacteria:BAA16541	intact:EBI-1121841|uniprotkb:P78244|ensemblbacteria:AAC75723|ensemblbacteria:BAA16541	psi-mi:rir4_ecoli(display_long)|uniprotkb:ygaD(gene name synonym)|uniprotkb:Ribonucleotide reductase 2(gene name synonym)|uniprotkb:R2F protein(gene name synonym)|uniprotkb:nrdF(gene name)|psi-mi:nrdF(display_short)|uniprotkb:b2676(locus name)|uniprotkb:JW2651(locus name)	psi-mi:rir4_ecoli(display_long)|uniprotkb:ygaD(gene name synonym)|uniprotkb:Ribonucleotide reductase 2(gene name synonym)|uniprotkb:R2F protein(gene name synonym)|uniprotkb:nrdF(gene name)|psi-mi:nrdF(display_short)|uniprotkb:b2676(locus name)|uniprotkb:JW2651(locus name)	psi-mi:"MI:0114"(x-ray crystallography)	Boal et al. (2010)	pubmed:20688982|imex:IM-28286	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-25682705|imex:IM-28286-1|wwpdb:3N37|wwpdb:3N38	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR026494|refseq:WP_000777969.1|ensemblbacteria:AAC75723(transcript)|ensemblbacteria:b2676(gene)|ensemblbacteria:BAA16541(gene)|ensemblbacteria:BAA16541(transcript)|go:"GO:0004748"(ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor)|go:"GO:0005506"(iron ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005971"(ribonucleoside-diphosphate reductase complex)|go:"GO:0006260"(DNA replication)|go:"GO:0009263"(deoxyribonucleotide biosynthetic process)|go:"GO:0030145"(manganese ion binding)|refseq:NP_417162.1|interpro:IPR009078(Ferritin/ribonucleotide reductase-like)|interpro:IPR000358(Ribonucleotide reductase)|rcsb pdb:3N37|rcsb pdb:3N38|rcsb pdb:3N39|rcsb pdb:3N3A|rcsb pdb:3N3B|interpro:IPR030475|rcsb pdb:4M1F|interpro:IPR033909|interpro:IPR012348(Ribonucleotide reductase-related)	interpro:IPR026494|refseq:WP_000777969.1|ensemblbacteria:AAC75723(transcript)|ensemblbacteria:b2676(gene)|ensemblbacteria:BAA16541(gene)|ensemblbacteria:BAA16541(transcript)|go:"GO:0004748"(ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor)|go:"GO:0005506"(iron ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005971"(ribonucleoside-diphosphate reductase complex)|go:"GO:0006260"(DNA replication)|go:"GO:0009263"(deoxyribonucleotide biosynthetic process)|go:"GO:0030145"(manganese ion binding)|refseq:NP_417162.1|interpro:IPR009078(Ferritin/ribonucleotide reductase-like)|interpro:IPR000358(Ribonucleotide reductase)|rcsb pdb:3N37|rcsb pdb:3N38|rcsb pdb:3N39|rcsb pdb:3N3A|rcsb pdb:3N3B|interpro:IPR030475|rcsb pdb:4M1F|interpro:IPR033909|interpro:IPR012348(Ribonucleotide reductase-related)	-	-	-	figure legend:Fig 1, Table S1, S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2020/06/20	2020/06/20	rogid:0zhJ89rd8u4Y29i6YSFFDDeO++o83333	rogid:0zhJ89rd8u4Y29i6YSFFDDeO++o83333	rigid:PmRohO1+WKZkqYuB6rCwVedY36w	false	-	-	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0A772	uniprotkb:P37146	intact:EBI-1112893|uniprotkb:P77025|uniprotkb:Q47415|ensemblbacteria:AAC75721|ensemblbacteria:BAA16538	intact:EBI-1121841|uniprotkb:P78244|ensemblbacteria:AAC75723|ensemblbacteria:BAA16541	psi-mi:nrdi_ecoli(display_long)|uniprotkb:ygaO(gene name synonym)|uniprotkb:nrdI(gene name)|psi-mi:nrdI(display_short)|uniprotkb:b2674(locus name)|uniprotkb:JW2649(locus name)	psi-mi:rir4_ecoli(display_long)|uniprotkb:ygaD(gene name synonym)|uniprotkb:Ribonucleotide reductase 2(gene name synonym)|uniprotkb:R2F protein(gene name synonym)|uniprotkb:nrdF(gene name)|psi-mi:nrdF(display_short)|uniprotkb:b2676(locus name)|uniprotkb:JW2651(locus name)	psi-mi:"MI:0114"(x-ray crystallography)	Boal et al. (2010)	pubmed:20688982|imex:IM-28286	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-25682710|imex:IM-28286-3|wwpdb:3N39|wwpdb:3N3A|wwpdb:3N3B	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:WP_000080947.1|refseq:NP_417160.1|interpro:IPR020852|interpro:IPR004465(Ribonucleotide reductase Class Ib, NrdI)|rcsb pdb:3N39|rcsb pdb:3N3A|rcsb pdb:3N3B|ensemblbacteria:AAC75721(transcript)|ensemblbacteria:b2674(gene)|ensemblbacteria:BAA16538(gene)|ensemblbacteria:BAA16538(transcript)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0010181"(FMN binding)|interpro:IPR029039	interpro:IPR026494|refseq:WP_000777969.1|ensemblbacteria:AAC75723(transcript)|ensemblbacteria:b2676(gene)|ensemblbacteria:BAA16541(gene)|ensemblbacteria:BAA16541(transcript)|go:"GO:0004748"(ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor)|go:"GO:0005506"(iron ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005971"(ribonucleoside-diphosphate reductase complex)|go:"GO:0006260"(DNA replication)|go:"GO:0009263"(deoxyribonucleotide biosynthetic process)|go:"GO:0030145"(manganese ion binding)|refseq:NP_417162.1|interpro:IPR009078(Ferritin/ribonucleotide reductase-like)|interpro:IPR000358(Ribonucleotide reductase)|rcsb pdb:3N37|rcsb pdb:3N38|rcsb pdb:3N39|rcsb pdb:3N3A|rcsb pdb:3N3B|interpro:IPR030475|rcsb pdb:4M1F|interpro:IPR033909|interpro:IPR012348(Ribonucleotide reductase-related)	-	-	-	figure legend:Fig 1, Table S1, S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2020/06/20	2020/08/24	rogid:bvi9AItQHO5OLl9czThXrAE67sk83333	rogid:0zhJ89rd8u4Y29i6YSFFDDeO++o83333	rigid:+jNy5+wMQyiuRsFHLAPkR45u/Ow	false	-	-	2	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)