#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q07654	uniprotkb:Q07654	intact:EBI-10224676|uniprotkb:Q96NX0|uniprotkb:Q9UDA5|uniprotkb:E9PBB5|ensembl:ENSP00000430690|uniprotkb:A0A0A6YYJ4	intact:EBI-10224676|uniprotkb:Q96NX0|uniprotkb:Q9UDA5|uniprotkb:E9PBB5|ensembl:ENSP00000430690|uniprotkb:A0A0A6YYJ4	psi-mi:tff3_human(display_long)|uniprotkb:TFF3(gene name)|psi-mi:TFF3(display_short)|uniprotkb:ITF(gene name synonym)|uniprotkb:Intestinal trefoil factor(gene name synonym)|uniprotkb:Polypeptide P1.B(gene name synonym)|uniprotkb:TFI(gene name synonym)	psi-mi:tff3_human(display_long)|uniprotkb:TFF3(gene name)|psi-mi:TFF3(display_short)|uniprotkb:ITF(gene name synonym)|uniprotkb:Intestinal trefoil factor(gene name synonym)|uniprotkb:Polypeptide P1.B(gene name synonym)|uniprotkb:TFI(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Albert et al. (2010)	imex:IM-28585|pubmed:20423149	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26567790|imex:IM-28585-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003217.3|ensembl:ENSG00000160180(gene)|ensembl:ENST00000518498(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0030141"(secretory granule)|go:"GO:0030277"(maintenance of gastrointestinal epithelium)|go:"GO:0042802"(identical protein binding)|interpro:IPR000519(P-type trefoil)|interpro:IPR017957|interpro:IPR017994|rcsb pdb:1E9T|rcsb pdb:1PE3|rcsb pdb:6V1C|reactome:R-HSA-9018519	refseq:NP_003217.3|ensembl:ENSG00000160180(gene)|ensembl:ENST00000518498(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0030141"(secretory granule)|go:"GO:0030277"(maintenance of gastrointestinal epithelium)|go:"GO:0042802"(identical protein binding)|interpro:IPR000519(P-type trefoil)|interpro:IPR017957|interpro:IPR017994|rcsb pdb:1E9T|rcsb pdb:1PE3|rcsb pdb:6V1C|reactome:R-HSA-9018519	-	-	-	figure legend:1D|comment:"TFF3 immunoreactive material in the low molecular weight fraction mainly represents TFF3/monomer and only very little TFF3/dimer (Figure 1D)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-colon)|taxid:9606(human colon)	-	2020/12/21	2020/12/21	rogid:xutYeQqn47plWzP4dGVzm1DEiTM9606	rogid:xutYeQqn47plWzP4dGVzm1DEiTM9606	rigid:DXQrczBDUFxvTtKwXWbaXxBDITU	false	-	-	2	0	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P01023	uniprotkb:Q9Y6R7	intact:EBI-640741|uniprotkb:Q13677|uniprotkb:Q59F47|uniprotkb:Q5QTS0|uniprotkb:Q68DN2|uniprotkb:Q6PIY3|uniprotkb:Q6PN97|ensembl:ENSP00000323929	intact:EBI-2869882|uniprotkb:O95784|ensembl:ENSP00000487490|ensembl:ENSP00000491148	psi-mi:a2mg_human(display_long)|uniprotkb:CPAMD5(gene name synonym)|uniprotkb:C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5(gene name synonym)|uniprotkb:A2M(gene name)|psi-mi:A2M(display_short)|uniprotkb:FWP007(orf name)	psi-mi:fcgbp_human(display_long)|uniprotkb:FCGBP(gene name)|psi-mi:FCGBP(display_short)|uniprotkb:Fcgamma-binding protein antigen(gene name synonym)	psi-mi:"MI:0404"(comigration in non denaturing gel electrophoresis)	Albert et al. (2010)	imex:IM-28585|pubmed:20423149	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26567859|imex:IM-28585-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000005.2|refseq:NP_001334352.1|refseq:NP_001334353.1|refseq:NP_001334354.1|interpro:IPR008930(Terpenoid cylases/protein prenyltransferase alpha-alpha toroid)|interpro:IPR009048(Alpha-macroglobulin, receptor-binding)|interpro:IPR010916(TonB box, conserved site)|interpro:IPR011625(Alpha-2-macroglobulin, N-terminal 2)|interpro:IPR011626(A-macroglobulin complement component)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR019742|interpro:IPR036595|interpro:IPR040839|interpro:IPR041555|interpro:IPR041813|mint:P01023|rcsb pdb:1BV8|rcsb pdb:2P9R|rcsb pdb:4ACQ|rcsb pdb:6TAV|reactome:R-HSA-114608|reactome:R-HSA-140837|reactome:R-HSA-1474228|reactome:R-HSA-8963896|ensembl:ENSG00000175899(gene)|ensembl:ENST00000318602(transcript)|go:"GO:0001869"(negative regulation of complement activation, lectin pathway)|go:"GO:0002020"(protease binding)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0019838"(growth factor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019959"(interleukin-8 binding)|go:"GO:0019966"(interleukin-1 binding)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR001599(Alpha-2-macroglobulin)|interpro:IPR002890(Alpha-2-macroglobulin, N-terminal)|dip:DIP-1118N	refseq:NP_003881.2|ensembl:ENSG00000281123(gene)|ensembl:ENST00000628705(transcript)|ensembl:ENST00000639918(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0031012"(extracellular matrix)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR001846(von Willebrand factor, type D)|interpro:IPR002919(Protease inhibitor I8, cysteine-rich trypsin inhibitor-like)|interpro:IPR003645(Follistatin-like, N-terminal)|interpro:IPR014853(Region of unknown function DUF1787)|interpro:IPR025615|interpro:IPR035234|interpro:IPR036084	-	-	-	figure legend:2, Table 1|comment:"Gel Bands , (M. wt) >500A and >500B"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-colon)|taxid:9606(human colon)	-	2020/12/21	2020/12/22	rogid:FClLRDrtOWUx0eBBCUfAocx0Q+49606	rogid:kYvvN+xLeF7WNsI4gg9KKjP/9vs9606	rigid:FDHRwJ9dc3xNzD28SdQEn9oH3sM	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P01023	uniprotkb:Q02817	intact:EBI-640741|uniprotkb:Q13677|uniprotkb:Q59F47|uniprotkb:Q5QTS0|uniprotkb:Q68DN2|uniprotkb:Q6PIY3|uniprotkb:Q6PN97|ensembl:ENSP00000323929	intact:EBI-2105803|uniprotkb:Q14878	psi-mi:a2mg_human(display_long)|uniprotkb:CPAMD5(gene name synonym)|uniprotkb:C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5(gene name synonym)|uniprotkb:A2M(gene name)|psi-mi:A2M(display_short)|uniprotkb:FWP007(orf name)	psi-mi:muc2_human(display_long)|uniprotkb:MUC2(gene name)|psi-mi:MUC2(display_short)|uniprotkb:SMUC(gene name synonym)|uniprotkb:Intestinal mucin-2(gene name synonym)	psi-mi:"MI:0404"(comigration in non denaturing gel electrophoresis)	Albert et al. (2010)	imex:IM-28585|pubmed:20423149	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26567859|imex:IM-28585-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000005.2|refseq:NP_001334352.1|refseq:NP_001334353.1|refseq:NP_001334354.1|interpro:IPR008930(Terpenoid cylases/protein prenyltransferase alpha-alpha toroid)|interpro:IPR009048(Alpha-macroglobulin, receptor-binding)|interpro:IPR010916(TonB box, conserved site)|interpro:IPR011625(Alpha-2-macroglobulin, N-terminal 2)|interpro:IPR011626(A-macroglobulin complement component)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR019742|interpro:IPR036595|interpro:IPR040839|interpro:IPR041555|interpro:IPR041813|mint:P01023|rcsb pdb:1BV8|rcsb pdb:2P9R|rcsb pdb:4ACQ|rcsb pdb:6TAV|reactome:R-HSA-114608|reactome:R-HSA-140837|reactome:R-HSA-1474228|reactome:R-HSA-8963896|ensembl:ENSG00000175899(gene)|ensembl:ENST00000318602(transcript)|go:"GO:0001869"(negative regulation of complement activation, lectin pathway)|go:"GO:0002020"(protease binding)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0019838"(growth factor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019959"(interleukin-8 binding)|go:"GO:0019966"(interleukin-1 binding)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR001599(Alpha-2-macroglobulin)|interpro:IPR002890(Alpha-2-macroglobulin, N-terminal)|dip:DIP-1118N	reactome:R-HSA-5083625|reactome:R-HSA-5083632|reactome:R-HSA-5083636|reactome:R-HSA-913709|reactome:R-HSA-977068|reactome:R-HSA-5621480|dip:DIP-48824N|go:"GO:0005615"(extracellular space)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0030277"(maintenance of gastrointestinal epithelium)|go:"GO:0031012"(extracellular matrix)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070702"(inner mucus layer)|go:"GO:0070703"(outer mucus layer)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR001846(von Willebrand factor, type D)|interpro:IPR002919(Protease inhibitor I8, cysteine-rich trypsin inhibitor-like)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR014853(Region of unknown function DUF1787)|interpro:IPR025155|interpro:IPR028580|interpro:IPR036084|rcsb pdb:6RBF|rcsb pdb:6TM6|rcsb pdb:7A5O	-	-	-	figure legend:2, Table 1|comment:"Gel Bands , (M. wt) >500A and >500B"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-colon)|taxid:9606(human colon)	-	2020/12/21	2020/12/22	rogid:FClLRDrtOWUx0eBBCUfAocx0Q+49606	rogid:8pzwGZXJw7CRgFAaNIuZgcTDxms9606	rigid:FDHRwJ9dc3xNzD28SdQEn9oH3sM	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:A8K7I4	uniprotkb:Q9Y6R7	intact:EBI-1171397|uniprotkb:O95151|uniprotkb:Q9UNF6|uniprotkb:Q9UPC6|uniprotkb:Q5TDF4|uniprotkb:B2RAV5|ensembl:ENSP00000234701|ensembl:ENSP00000378200	intact:EBI-2869882|uniprotkb:O95784|ensembl:ENSP00000487490|ensembl:ENSP00000491148	psi-mi:clca1_human(display_long)|uniprotkb:Calcium-activated chloride channel family member 1(gene name synonym)|uniprotkb:Calcium-activated chloride channel protein 1(gene name synonym)|uniprotkb:CLCA1(gene name)|psi-mi:CLCA1(display_short)|uniprotkb:CACC1(gene name synonym)	psi-mi:fcgbp_human(display_long)|uniprotkb:FCGBP(gene name)|psi-mi:FCGBP(display_short)|uniprotkb:Fcgamma-binding protein antigen(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Albert et al. (2010)	imex:IM-28585|pubmed:20423149	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26567873|imex:IM-28585-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001276.2|ensembl:ENSG00000016490(gene)|ensembl:ENST00000234701(transcript)|ensembl:ENST00000394711(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005229"(intracellular calcium activated chloride channel activity)|go:"GO:0005254"(chloride channel activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0042589"(zymogen granule membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0071456"(cellular response to hypoxia)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR004727(Calcium-activated chloride channel protein)|interpro:IPR013642(Chloride channel calcium-activated)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036465|rcsb pdb:6PYX|reactome:R-HSA-2672351|rcsb pdb:6PYO	refseq:NP_003881.2|ensembl:ENSG00000281123(gene)|ensembl:ENST00000628705(transcript)|ensembl:ENST00000639918(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0031012"(extracellular matrix)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR001846(von Willebrand factor, type D)|interpro:IPR002919(Protease inhibitor I8, cysteine-rich trypsin inhibitor-like)|interpro:IPR003645(Follistatin-like, N-terminal)|interpro:IPR014853(Region of unknown function DUF1787)|interpro:IPR025615|interpro:IPR035234|interpro:IPR036084	-	-	-	figure legend:2, Table 1|comment:"Gel Bands , (M. wt) <500."|comment:Most bands also contained different isoforms of  cytokeratins or fragments thereof which were regarded as  typical contaminants.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-colon)|taxid:9606(human colon)	-	2020/12/21	2020/12/22	rogid:qjuuqU0UVwgGb+ASJsLcxYIPGyg9606	rogid:kYvvN+xLeF7WNsI4gg9KKjP/9vs9606	rigid:scvhpUDvwsWxD7cqb5AbSZHi3+s	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:A8K7I4	uniprotkb:P01876	intact:EBI-1171397|uniprotkb:O95151|uniprotkb:Q9UNF6|uniprotkb:Q9UPC6|uniprotkb:Q5TDF4|uniprotkb:B2RAV5|ensembl:ENSP00000234701|ensembl:ENSP00000378200	intact:EBI-727651|ensembl:ENSP00000374989|ensembl:ENSP00000488021	psi-mi:clca1_human(display_long)|uniprotkb:Calcium-activated chloride channel family member 1(gene name synonym)|uniprotkb:Calcium-activated chloride channel protein 1(gene name synonym)|uniprotkb:CLCA1(gene name)|psi-mi:CLCA1(display_short)|uniprotkb:CACC1(gene name synonym)	psi-mi:igha1_human(display_long)|uniprotkb:IGHA1(gene name)|psi-mi:IGHA1(display_short)|uniprotkb:Ig alpha-1 chain C region(gene name synonym)|uniprotkb:Ig alpha-1 chain C region BUR(gene name synonym)|uniprotkb:Ig alpha-1 chain C region TRO(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Albert et al. (2010)	imex:IM-28585|pubmed:20423149	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26567873|imex:IM-28585-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001276.2|ensembl:ENSG00000016490(gene)|ensembl:ENST00000234701(transcript)|ensembl:ENST00000394711(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005229"(intracellular calcium activated chloride channel activity)|go:"GO:0005254"(chloride channel activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0042589"(zymogen granule membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0071456"(cellular response to hypoxia)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR004727(Calcium-activated chloride channel protein)|interpro:IPR013642(Chloride channel calcium-activated)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036465|rcsb pdb:6PYX|reactome:R-HSA-2672351|rcsb pdb:6PYO	ensembl:ENSG00000211895(gene)|ensembl:ENSG00000282633(gene)|ensembl:ENST00000390547(transcript)|ensembl:ENST00000633714(transcript)|go:"GO:0001895"(retina homeostasis)|go:"GO:0003094"(glomerular filtration)|go:"GO:0003823"(antigen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006955"(immune response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0018298"(protein-chromophore linkage)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0042571"(immunoglobulin complex, circulating)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0060267"(positive regulation of respiratory burst)|go:"GO:0071748"(monomeric IgA immunoglobulin complex)|go:"GO:0071751"(secretory IgA immunoglobulin complex)|go:"GO:0071752"(secretory dimeric IgA immunoglobulin complex)|go:"GO:0072562"(blood microparticle)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1IGA|rcsb pdb:1OW0|rcsb pdb:2ESG|rcsb pdb:2QEJ|rcsb pdb:3CHN|rcsb pdb:6LX3|rcsb pdb:6LXW|rcsb pdb:6UE7|rcsb pdb:6XJA|reactome:R-HSA-202733|reactome:R-HSA-2168880|go:"GO:0070062"(extracellular exosome)	-	-	-	figure legend:2, Table 1|comment:"Gel Bands , (M. wt) <500."|comment:Most bands also contained different isoforms of  cytokeratins or fragments thereof which were regarded as  typical contaminants.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-colon)|taxid:9606(human colon)	-	2020/12/21	2020/12/22	rogid:qjuuqU0UVwgGb+ASJsLcxYIPGyg9606	rogid:Mystbtg9uttxFXl//LGdoM32po09606	rigid:scvhpUDvwsWxD7cqb5AbSZHi3+s	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:A8K7I4	uniprotkb:P01857	intact:EBI-1171397|uniprotkb:O95151|uniprotkb:Q9UNF6|uniprotkb:Q9UPC6|uniprotkb:Q5TDF4|uniprotkb:B2RAV5|ensembl:ENSP00000234701|ensembl:ENSP00000378200	intact:EBI-356114|ensembl:ENSP00000374991|ensembl:ENSP00000488387	psi-mi:clca1_human(display_long)|uniprotkb:Calcium-activated chloride channel family member 1(gene name synonym)|uniprotkb:Calcium-activated chloride channel protein 1(gene name synonym)|uniprotkb:CLCA1(gene name)|psi-mi:CLCA1(display_short)|uniprotkb:CACC1(gene name synonym)	psi-mi:ighg1_human(display_long)|uniprotkb:IGHG1(gene name)|psi-mi:IGHG1(display_short)|uniprotkb:Ig gamma-1 chain C region(gene name synonym)|uniprotkb:Ig gamma-1 chain C region EU(gene name synonym)|uniprotkb:Ig gamma-1 chain C region KOL(gene name synonym)|uniprotkb:Ig gamma-1 chain C region NIE(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Albert et al. (2010)	imex:IM-28585|pubmed:20423149	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26567873|imex:IM-28585-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001276.2|ensembl:ENSG00000016490(gene)|ensembl:ENST00000234701(transcript)|ensembl:ENST00000394711(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005229"(intracellular calcium activated chloride channel activity)|go:"GO:0005254"(chloride channel activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0042589"(zymogen granule membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0071456"(cellular response to hypoxia)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR004727(Calcium-activated chloride channel protein)|interpro:IPR013642(Chloride channel calcium-activated)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036465|rcsb pdb:6PYX|reactome:R-HSA-2672351|rcsb pdb:6PYO	ensembl:ENSG00000211896(gene)|ensembl:ENSG00000277633(gene)|ensembl:ENST00000390549(transcript)|ensembl:ENST00000631466(transcript)|go:"GO:0003823"(antigen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0034987"(immunoglobulin receptor binding)|go:"GO:0042571"(immunoglobulin complex, circulating)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P01857|rcsb pdb:1AJ7|rcsb pdb:1AQK|rcsb pdb:1AXS|rcsb pdb:1BEY|rcsb pdb:1D5B|rcsb pdb:1D5I|rcsb pdb:1D6V|rcsb pdb:1DFB|rcsb pdb:1DN2|rcsb pdb:1E4K|rcsb pdb:1FC1|rcsb pdb:1FC2|rcsb pdb:1FCC|rcsb pdb:1GAF|rcsb pdb:1H3T|rcsb pdb:1H3U|rcsb pdb:1H3V|rcsb pdb:1H3W|rcsb pdb:1H3X|rcsb pdb:1H3Y|rcsb pdb:1HKL|rcsb pdb:1HZH|rcsb pdb:1L6X|rcsb pdb:1N7M|rcsb pdb:1OQO|rcsb pdb:1OQX|rcsb pdb:1PG7|rcsb pdb:1T83|rcsb pdb:1T89|rcsb pdb:1VGE|rcsb pdb:2DTS|rcsb pdb:2GJ7|rcsb pdb:2I5Y|rcsb pdb:2IWG|rcsb pdb:2J6E|rcsb pdb:2JB5|rcsb pdb:2JB6|rcsb pdb:2O5X|rcsb pdb:2O5Y|rcsb pdb:2O5Z|rcsb pdb:2OSL|rcsb pdb:2QAD|rcsb pdb:2QL1|rcsb pdb:2QQK|rcsb pdb:2QQL|rcsb pdb:2QQN|rcsb pdb:2QR0|rcsb pdb:2R56|rcsb pdb:2RCS|rcsb pdb:2VXQ|rcsb pdb:2WAH|rcsb pdb:3AGV|rcsb pdb:3AVE|rcsb pdb:3AY4|rcsb pdb:3B2U|rcsb pdb:3B2V|rcsb pdb:3BDY|rcsb pdb:3BE1|rcsb pdb:3BKY|rcsb pdb:3BN9|rcsb pdb:3BQU|rcsb pdb:3C08|rcsb pdb:3C09|rcsb pdb:3C2S|rcsb pdb:3CFJ|rcsb pdb:3CFK|rcsb pdb:3CSY|rcsb pdb:3D0L|rcsb pdb:3D0V|rcsb pdb:3D6G|rcsb pdb:3D85|rcsb pdb:3DJ9|rcsb pdb:3DNK|rcsb pdb:3DO3|rcsb pdb:3DRO|rcsb pdb:3DRQ|rcsb pdb:3DVG|rcsb pdb:3DVN|rcsb pdb:3EYF|rcsb pdb:3EYO|rcsb pdb:3EYQ|rcsb pdb:3FJT|rcsb pdb:3MCL|rcsb pdb:3O11|rcsb pdb:3RY6|rcsb pdb:3S7G|rcsb pdb:3SGJ|rcsb pdb:3SGK|rcsb pdb:3TV3|rcsb pdb:3TWC|rcsb pdb:3TYG|rcsb pdb:3U0W|rcsb pdb:3U7W|rcsb pdb:3U7Y|rcsb pdb:3V7M|rcsb pdb:3V8C|rcsb pdb:3V95|rcsb pdb:3WJJ|rcsb pdb:1I7Z|rcsb pdb:3WJL|rcsb pdb:3WN5|rcsb pdb:4ACP|rcsb pdb:4B7I|rcsb pdb:4BM7|rcsb pdb:4BSV|rcsb pdb:4BSW|rcsb pdb:4BYH|rcsb pdb:4CDH|rcsb pdb:4D9Q|rcsb pdb:4D9R|rcsb pdb:4DAG|rcsb pdb:4DZ8|rcsb pdb:4EOW|rcsb pdb:4HIX|rcsb pdb:4J12|rcsb pdb:4KU1|rcsb pdb:4LLD|rcsb pdb:4LLM|rcsb pdb:4LLQ|rcsb pdb:4N0U|rcsb pdb:4NQS|rcsb pdb:4NQT|rcsb pdb:4NQU|rcsb pdb:4NWT|rcsb pdb:4NWU|rcsb pdb:4O4Y|rcsb pdb:4O51|rcsb pdb:4Q6Y|rcsb pdb:4Q74|rcsb pdb:4Q7D|rcsb pdb:3WKN|rcsb pdb:4W4N|rcsb pdb:4W4O|rcsb pdb:4WI2|rcsb pdb:4WI3|rcsb pdb:4WI4|rcsb pdb:4WI5|rcsb pdb:4WI6|rcsb pdb:4WI7|rcsb pdb:4WI8|rcsb pdb:4WI9|rcsb pdb:4X4M|rcsb pdb:4X98|rcsb pdb:4X99|rcsb pdb:4XMP|rcsb pdb:4XNY|rcsb pdb:4XXD|rcsb pdb:4ZNE|rcsb pdb:5BW7|rcsb pdb:5D4Q|rcsb pdb:5D6D|rcsb pdb:5DI8|rcsb pdb:5DJ0|rcsb pdb:5DJ2|rcsb pdb:5DJ6|rcsb pdb:5DJ8|rcsb pdb:5DJA|rcsb pdb:5DJC|rcsb pdb:5DJD|rcsb pdb:5DJX|rcsb pdb:5DJY|rcsb pdb:5DJZ|rcsb pdb:5DK0|rcsb pdb:5DK2|rcsb pdb:5DVK|rcsb pdb:5DVL|rcsb pdb:5DVM|rcsb pdb:5DVN|rcsb pdb:5DVO|rcsb pdb:5GSQ|rcsb pdb:5HSF|rcsb pdb:5HY9|rcsb pdb:5HYE|rcsb pdb:5HYF|rcsb pdb:5HYI|rcsb pdb:5IQ7|rcsb pdb:5IQ9|rcsb pdb:5IW3|rcsb pdb:5IW6|rcsb pdb:5JIH|rcsb pdb:5JII|rcsb pdb:5JIK|rcsb pdb:5K33|rcsb pdb:5K64|rcsb pdb:5K65|rcsb pdb:5K8D|rcsb pdb:5KWG|rcsb pdb:5M3V|rcsb pdb:5TPS|rcsb pdb:5U4Y|rcsb pdb:5U52|rcsb pdb:5U66|rcsb pdb:5V43|rcsb pdb:5V4E|rcsb pdb:6DCV|rcsb pdb:6DCW|rcsb pdb:6DE7|rcsb pdb:6F2Z|rcsb pdb:6G1E|rcsb pdb:6N35|rcsb pdb:6YT7|rcsb pdb:7KWO|reactome:R-HSA-166663|rcsb pdb:4XNZ|reactome:R-HSA-173623|reactome:R-HSA-2029481|reactome:R-HSA-2029482|reactome:R-HSA-2029485|reactome:R-HSA-6785807|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-977606|dip:DIP-29187N	-	-	-	figure legend:2, Table 1|comment:"Gel Bands , (M. wt) <500."|comment:Most bands also contained different isoforms of  cytokeratins or fragments thereof which were regarded as  typical contaminants.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-colon)|taxid:9606(human colon)	-	2020/12/21	2020/12/22	rogid:qjuuqU0UVwgGb+ASJsLcxYIPGyg9606	rogid:1YK8rrTDnOYYKW5wHI48/rYlr5o9606	rigid:scvhpUDvwsWxD7cqb5AbSZHi3+s	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y6R7	uniprotkb:Q07654	intact:EBI-2869882|uniprotkb:O95784|ensembl:ENSP00000487490|ensembl:ENSP00000491148	intact:EBI-10224676|uniprotkb:Q96NX0|uniprotkb:Q9UDA5|uniprotkb:E9PBB5|ensembl:ENSP00000430690|uniprotkb:A0A0A6YYJ4	psi-mi:fcgbp_human(display_long)|uniprotkb:FCGBP(gene name)|psi-mi:FCGBP(display_short)|uniprotkb:Fcgamma-binding protein antigen(gene name synonym)	psi-mi:tff3_human(display_long)|uniprotkb:TFF3(gene name)|psi-mi:TFF3(display_short)|uniprotkb:ITF(gene name synonym)|uniprotkb:Intestinal trefoil factor(gene name synonym)|uniprotkb:Polypeptide P1.B(gene name synonym)|uniprotkb:TFI(gene name synonym)	psi-mi:"MI:0404"(comigration in non denaturing gel electrophoresis)	Albert et al. (2010)	imex:IM-28585|pubmed:20423149	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26567909|imex:IM-28585-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003881.2|ensembl:ENSG00000281123(gene)|ensembl:ENST00000628705(transcript)|ensembl:ENST00000639918(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0031012"(extracellular matrix)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR001846(von Willebrand factor, type D)|interpro:IPR002919(Protease inhibitor I8, cysteine-rich trypsin inhibitor-like)|interpro:IPR003645(Follistatin-like, N-terminal)|interpro:IPR014853(Region of unknown function DUF1787)|interpro:IPR025615|interpro:IPR035234|interpro:IPR036084	refseq:NP_003217.3|ensembl:ENSG00000160180(gene)|ensembl:ENST00000518498(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0030141"(secretory granule)|go:"GO:0030277"(maintenance of gastrointestinal epithelium)|go:"GO:0042802"(identical protein binding)|interpro:IPR000519(P-type trefoil)|interpro:IPR017957|interpro:IPR017994|rcsb pdb:1E9T|rcsb pdb:1PE3|rcsb pdb:6V1C|reactome:R-HSA-9018519	-	-	-	figure legend:3A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-colon)|taxid:9606(human colon)	-	2020/12/21	2020/12/22	rogid:kYvvN+xLeF7WNsI4gg9KKjP/9vs9606	rogid:xutYeQqn47plWzP4dGVzm1DEiTM9606	rigid:0+SSiu8GN6NB0dlU8gU3mGY7opQ	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)