#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P0C6X7-PRO_0000037312 uniprotkb:P0C6X7-PRO_0000037312 intact:EBI-25487250 intact:EBI-25487250 psi-mi:p0c6x7-pro_0000037312(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:p0c6x7-pro_0000037312(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:"MI:0114"(x-ray crystallography) Barrila et al. (2010) pubmed:20420403|imex:IM-27989 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-25612448|imex:IM-27989-1|pdbe:3FZD - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7843867(chain-parent) intact:EBI-7843867(chain-parent) - chain-seq-start:3241|chain-seq-end:3546 chain-seq-start:3241|chain-seq-end:3546 figure legend:Table 2|3d-resolution:2.35Å|3d-r-factors:"Rwork: 0.214 Rfree: 0.277"|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/05/18 2020/06/18 rogid:6LbRC/jITHtqNPZLpKst/+pNdOQ694009 rogid:6LbRC/jITHtqNPZLpKst/+pNdOQ694009 rigid:oE/7cURQPcwCKosVpVBZnUBkgKI false mutation decreasing interaction strength:28-28 mutation decreasing interaction strength:28-28 2 0 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P0C6X7-PRO_0000037312 intact:EBI-25612655 intact:EBI-25487250 - psi-mi:p0c6x7-pro_0000037312(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:dabcyl-ktsavlqsgfrkme-edans(display_short)|psi-mi:EBI-25612655(display_long) psi-mi:"MI:0435"(protease assay) Barrila et al. (2010) pubmed:20420403|imex:IM-27989 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") psi-mi:"MI:0570"(protein cleavage) psi-mi:"MI:0469"(IntAct) intact:EBI-25612668|imex:IM-27989-3 - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0327"(peptide) intact:EBI-7843867(chain-parent) pubmed:18583140(see-also) - chain-seq-start:3241|chain-seq-end:3546 - figure legend:Table 1, Figure 2a|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) km:56.0x10^-6 ~9.0(molar)|kcat:0.64x1^1 ~0.05(second -1) 2020/05/18 2020/06/18 rogid:6LbRC/jITHtqNPZLpKst/+pNdOQ694009 rogid:5paWG8TKpS+Vdd4uWaMMBd0QUBk-2 rigid:ugDhjfSu/lH3MDm+igckY9ScIBs false mutation decreasing interaction rate:28-28 - - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:P0C6X7-PRO_0000037312 uniprotkb:P0C6X7-PRO_0000037312 intact:EBI-25487250 intact:EBI-25487250 psi-mi:p0c6x7-pro_0000037312(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:p0c6x7-pro_0000037312(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:"MI:0028"(cosedimentation in solution) Barrila et al. (2010) pubmed:20420403|imex:IM-27989 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-25612722|imex:IM-27989-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7843867(chain-parent) intact:EBI-7843867(chain-parent) - chain-seq-start:3241|chain-seq-end:3546 chain-seq-start:3241|chain-seq-end:3546 figure legend:Table 1, Fig 3|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:1.3x10^-6 ~0.8(molar) 2020/05/18 2020/06/18 rogid:6LbRC/jITHtqNPZLpKst/+pNdOQ694009 rogid:6LbRC/jITHtqNPZLpKst/+pNdOQ694009 rigid:oE/7cURQPcwCKosVpVBZnUBkgKI false mutation decreasing interaction strength:28-28 mutation decreasing interaction strength:28-28 2 0 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)