#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P62554	uniprotkb:P62552	intact:EBI-25647730|uniprotkb:P05703	intact:EBI-25647704|uniprotkb:P05702	psi-mi:ccdb_ecoli(display_long)|uniprotkb:ccdB(gene name)|psi-mi:ccdB(display_short)|uniprotkb:G(gene name synonym)|uniprotkb:letB(gene name synonym)|uniprotkb:letD(gene name synonym)|uniprotkb:ECOK12F043(locus name)|uniprotkb:Cytotoxic protein CcdB(gene name synonym)|uniprotkb:LynB(gene name synonym)|uniprotkb:Protein G(gene name synonym)|uniprotkb:Protein LetD(gene name synonym)	psi-mi:ccda_ecoli(display_long)|uniprotkb:ccdA(gene name)|psi-mi:ccdA(display_short)|uniprotkb:H(gene name synonym)|uniprotkb:letA(gene name synonym)|uniprotkb:ECOK12F042(locus name)|uniprotkb:LynA(gene name synonym)|uniprotkb:Protein H(gene name synonym)|uniprotkb:Protein LetA(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	De et al. (2009)	imex:IM-28247|pubmed:19647513	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-25647753|imex:IM-28247-1|wwpdb:3G7Z	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0006276"(plasmid maintenance)|go:"GO:0008657"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity")|refseq:NP_061422.1|refseq:WP_001159868.1|refseq:YP_003108267.1|rcsb pdb:1VUB|rcsb pdb:1X75|rcsb pdb:2VUB|rcsb pdb:3G7Z|rcsb pdb:3HPW|rcsb pdb:3VUB|rcsb pdb:4VUB|interpro:IPR002712(CcdB protein)|interpro:IPR011067(Plasmid maintenance toxin/Cell growth inhibitor)	go:"GO:0003677"(DNA binding)|refseq:NP_061421.1|refseq:WP_000813634.1|refseq:YP_001816480.1|refseq:YP_003108266.1|refseq:YP_003162544.1|refseq:YP_003829105.1|refseq:YP_003829230.1|refseq:YP_006940499.1|refseq:YP_424850.1|refseq:YP_788019.1|rcsb pdb:2ADL|rcsb pdb:2ADN|rcsb pdb:2H3A|rcsb pdb:2H3C|rcsb pdb:3G7Z|rcsb pdb:3HPW|interpro:IPR009956(Post-segregation antitoxin CcdA)	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/06/15	2020/06/15	rogid:VI6U/gzKwdl+WPL2FxAigN49i4o83333	rogid:NFxGRso8ws1Le8CdtjsAr4O3krE83333	rigid:aKp0DnIc6YR66p7OZUgO4MSH2gg	false	-	sufficient binding region:37-72	2	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P62554	uniprotkb:P62552	intact:EBI-25647730|uniprotkb:P05703	intact:EBI-25647704|uniprotkb:P05702	psi-mi:ccdb_ecoli(display_long)|uniprotkb:ccdB(gene name)|psi-mi:ccdB(display_short)|uniprotkb:G(gene name synonym)|uniprotkb:letB(gene name synonym)|uniprotkb:letD(gene name synonym)|uniprotkb:ECOK12F043(locus name)|uniprotkb:Cytotoxic protein CcdB(gene name synonym)|uniprotkb:LynB(gene name synonym)|uniprotkb:Protein G(gene name synonym)|uniprotkb:Protein LetD(gene name synonym)	psi-mi:ccda_ecoli(display_long)|uniprotkb:ccdA(gene name)|psi-mi:ccdA(display_short)|uniprotkb:H(gene name synonym)|uniprotkb:letA(gene name synonym)|uniprotkb:ECOK12F042(locus name)|uniprotkb:LynA(gene name synonym)|uniprotkb:Protein H(gene name synonym)|uniprotkb:Protein LetA(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	De et al. (2009)	imex:IM-28247|pubmed:19647513	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-25647760|imex:IM-28247-3|wwpdb:3hpw	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0006276"(plasmid maintenance)|go:"GO:0008657"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity")|refseq:NP_061422.1|refseq:WP_001159868.1|refseq:YP_003108267.1|rcsb pdb:1VUB|rcsb pdb:1X75|rcsb pdb:2VUB|rcsb pdb:3G7Z|rcsb pdb:3HPW|rcsb pdb:3VUB|rcsb pdb:4VUB|interpro:IPR002712(CcdB protein)|interpro:IPR011067(Plasmid maintenance toxin/Cell growth inhibitor)	go:"GO:0003677"(DNA binding)|refseq:NP_061421.1|refseq:WP_000813634.1|refseq:YP_001816480.1|refseq:YP_003108266.1|refseq:YP_003162544.1|refseq:YP_003829105.1|refseq:YP_003829230.1|refseq:YP_006940499.1|refseq:YP_424850.1|refseq:YP_788019.1|rcsb pdb:2ADL|rcsb pdb:2ADN|rcsb pdb:2H3A|rcsb pdb:2H3C|rcsb pdb:3G7Z|rcsb pdb:3HPW|interpro:IPR009956(Post-segregation antitoxin CcdA)	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/06/15	2020/06/15	rogid:VI6U/gzKwdl+WPL2FxAigN49i4o83333	rogid:NFxGRso8ws1Le8CdtjsAr4O3krE83333	rigid:aKp0DnIc6YR66p7OZUgO4MSH2gg	false	-	sufficient binding region:37-72	2	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P62554	uniprotkb:P0AES4	intact:EBI-25647730|uniprotkb:P05703	intact:EBI-547129|uniprotkb:P09097|ensemblbacteria:AAC75291|ensemblbacteria:BAA16048	psi-mi:ccdb_ecoli(display_long)|uniprotkb:ccdB(gene name)|psi-mi:ccdB(display_short)|uniprotkb:G(gene name synonym)|uniprotkb:letB(gene name synonym)|uniprotkb:letD(gene name synonym)|uniprotkb:ECOK12F043(locus name)|uniprotkb:Cytotoxic protein CcdB(gene name synonym)|uniprotkb:LynB(gene name synonym)|uniprotkb:Protein G(gene name synonym)|uniprotkb:Protein LetD(gene name synonym)	psi-mi:gyra_ecoli(display_long)|uniprotkb:hisW(gene name synonym)|uniprotkb:nalA(gene name synonym)|uniprotkb:parD(gene name synonym)|uniprotkb:b2231(locus name)|uniprotkb:gyrA(gene name)|psi-mi:gyrA(display_short)|uniprotkb:JW2225(locus name)	psi-mi:"MI:0107"(surface plasmon resonance)	De et al. (2009)	imex:IM-28247|pubmed:19647513	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-25647801|imex:IM-28247-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0006276"(plasmid maintenance)|go:"GO:0008657"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity")|refseq:NP_061422.1|refseq:WP_001159868.1|refseq:YP_003108267.1|rcsb pdb:1VUB|rcsb pdb:1X75|rcsb pdb:2VUB|rcsb pdb:3G7Z|rcsb pdb:3HPW|rcsb pdb:3VUB|rcsb pdb:4VUB|interpro:IPR002712(CcdB protein)|interpro:IPR011067(Plasmid maintenance toxin/Cell growth inhibitor)	refseq:NP_416734.1|refseq:WP_001281242.1|ensemblbacteria:AAC75291(transcript)|ensemblbacteria:b2231(gene)|ensemblbacteria:BAA16048(gene)|ensemblbacteria:BAA16048(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0006265"(DNA topological change)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0009330"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex")|go:"GO:0016020"(membrane)|go:"GO:0034335"(DNA negative supercoiling activity)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0046677"(response to antibiotic)|interpro:IPR002205(DNA topoisomerase, type IIA, subunit A or C-terminal)|interpro:IPR005743(DNA gyrase, subunit A)|interpro:IPR006691(DNA gyrase/topoisomerase IV, subunit A, C-terminal beta-pinwheel)|interpro:IPR013760(DNA topoisomerase, type IIA, central)|interpro:IPR035516|rcsb pdb:1AB4|rcsb pdb:1X75|rcsb pdb:1ZI0|rcsb pdb:2Y3P|rcsb pdb:3NUH|rcsb pdb:4ELY|rcsb pdb:6RKS|rcsb pdb:6RKU|rcsb pdb:6RKV|rcsb pdb:6RKW|dip:DIP-36179N	-	-	-	figure legend:Fig. 3A, 3B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/06/15	2020/06/15	rogid:VI6U/gzKwdl+WPL2FxAigN49i4o83333	rogid:O5WW4A/0lHpHyyIaahw9PQkc/Ug83333	rigid:H0oO9UVwGAj3rrFtzlVJNgypMmg	false	-	sufficient binding region:2-253|his tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P62554	uniprotkb:P62552	intact:EBI-25647730|uniprotkb:P05703	intact:EBI-25647704|uniprotkb:P05702	psi-mi:ccdb_ecoli(display_long)|uniprotkb:ccdB(gene name)|psi-mi:ccdB(display_short)|uniprotkb:G(gene name synonym)|uniprotkb:letB(gene name synonym)|uniprotkb:letD(gene name synonym)|uniprotkb:ECOK12F043(locus name)|uniprotkb:Cytotoxic protein CcdB(gene name synonym)|uniprotkb:LynB(gene name synonym)|uniprotkb:Protein G(gene name synonym)|uniprotkb:Protein LetD(gene name synonym)	psi-mi:ccda_ecoli(display_long)|uniprotkb:ccdA(gene name)|psi-mi:ccdA(display_short)|uniprotkb:H(gene name synonym)|uniprotkb:letA(gene name synonym)|uniprotkb:ECOK12F042(locus name)|uniprotkb:LynA(gene name synonym)|uniprotkb:Protein H(gene name synonym)|uniprotkb:Protein LetA(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	De et al. (2009)	imex:IM-28247|pubmed:19647513	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-25647811|imex:IM-28247-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0006276"(plasmid maintenance)|go:"GO:0008657"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity")|refseq:NP_061422.1|refseq:WP_001159868.1|refseq:YP_003108267.1|rcsb pdb:1VUB|rcsb pdb:1X75|rcsb pdb:2VUB|rcsb pdb:3G7Z|rcsb pdb:3HPW|rcsb pdb:3VUB|rcsb pdb:4VUB|interpro:IPR002712(CcdB protein)|interpro:IPR011067(Plasmid maintenance toxin/Cell growth inhibitor)	go:"GO:0003677"(DNA binding)|refseq:NP_061421.1|refseq:WP_000813634.1|refseq:YP_001816480.1|refseq:YP_003108266.1|refseq:YP_003162544.1|refseq:YP_003829105.1|refseq:YP_003829230.1|refseq:YP_006940499.1|refseq:YP_424850.1|refseq:YP_788019.1|rcsb pdb:2ADL|rcsb pdb:2ADN|rcsb pdb:2H3A|rcsb pdb:2H3C|rcsb pdb:3G7Z|rcsb pdb:3HPW|interpro:IPR009956(Post-segregation antitoxin CcdA)	-	-	-	figure legend:Supp Fig 4A, 4C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/06/15	2020/11/16	rogid:VI6U/gzKwdl+WPL2FxAigN49i4o83333	rogid:NFxGRso8ws1Le8CdtjsAr4O3krE83333	rigid:aKp0DnIc6YR66p7OZUgO4MSH2gg	false	-	sufficient binding region:37-62|sufficient binding region:37-72	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0AES4	uniprotkb:P62554	intact:EBI-547129|uniprotkb:P09097|ensemblbacteria:AAC75291|ensemblbacteria:BAA16048	intact:EBI-25647730|uniprotkb:P05703	psi-mi:gyra_ecoli(display_long)|uniprotkb:hisW(gene name synonym)|uniprotkb:nalA(gene name synonym)|uniprotkb:parD(gene name synonym)|uniprotkb:b2231(locus name)|uniprotkb:gyrA(gene name)|psi-mi:gyrA(display_short)|uniprotkb:JW2225(locus name)	psi-mi:ccdb_ecoli(display_long)|uniprotkb:ccdB(gene name)|psi-mi:ccdB(display_short)|uniprotkb:G(gene name synonym)|uniprotkb:letB(gene name synonym)|uniprotkb:letD(gene name synonym)|uniprotkb:ECOK12F043(locus name)|uniprotkb:Cytotoxic protein CcdB(gene name synonym)|uniprotkb:LynB(gene name synonym)|uniprotkb:Protein G(gene name synonym)|uniprotkb:Protein LetD(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	De et al. (2009)	imex:IM-28247|pubmed:19647513	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-25647822|imex:IM-28247-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_416734.1|refseq:WP_001281242.1|ensemblbacteria:AAC75291(transcript)|ensemblbacteria:b2231(gene)|ensemblbacteria:BAA16048(gene)|ensemblbacteria:BAA16048(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0006265"(DNA topological change)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0009330"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex")|go:"GO:0016020"(membrane)|go:"GO:0034335"(DNA negative supercoiling activity)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0046677"(response to antibiotic)|interpro:IPR002205(DNA topoisomerase, type IIA, subunit A or C-terminal)|interpro:IPR005743(DNA gyrase, subunit A)|interpro:IPR006691(DNA gyrase/topoisomerase IV, subunit A, C-terminal beta-pinwheel)|interpro:IPR013760(DNA topoisomerase, type IIA, central)|interpro:IPR035516|rcsb pdb:1AB4|rcsb pdb:1X75|rcsb pdb:1ZI0|rcsb pdb:2Y3P|rcsb pdb:3NUH|rcsb pdb:4ELY|rcsb pdb:6RKS|rcsb pdb:6RKU|rcsb pdb:6RKV|rcsb pdb:6RKW|dip:DIP-36179N	go:"GO:0006276"(plasmid maintenance)|go:"GO:0008657"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity")|refseq:NP_061422.1|refseq:WP_001159868.1|refseq:YP_003108267.1|rcsb pdb:1VUB|rcsb pdb:1X75|rcsb pdb:2VUB|rcsb pdb:3G7Z|rcsb pdb:3HPW|rcsb pdb:3VUB|rcsb pdb:4VUB|interpro:IPR002712(CcdB protein)|interpro:IPR011067(Plasmid maintenance toxin/Cell growth inhibitor)	-	-	-	figure legend:Fig. 3A,3B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/06/15	2020/06/15	rogid:O5WW4A/0lHpHyyIaahw9PQkc/Ug83333	rogid:VI6U/gzKwdl+WPL2FxAigN49i4o83333	rigid:DPW1lmbXdW0fbTBZeGcuUzaMhyI	false	sufficient binding region:2-253|his tag:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0AES4	uniprotkb:P62552	intact:EBI-547129|uniprotkb:P09097|ensemblbacteria:AAC75291|ensemblbacteria:BAA16048	intact:EBI-25647704|uniprotkb:P05702	psi-mi:gyra_ecoli(display_long)|uniprotkb:hisW(gene name synonym)|uniprotkb:nalA(gene name synonym)|uniprotkb:parD(gene name synonym)|uniprotkb:b2231(locus name)|uniprotkb:gyrA(gene name)|psi-mi:gyrA(display_short)|uniprotkb:JW2225(locus name)	psi-mi:ccda_ecoli(display_long)|uniprotkb:ccdA(gene name)|psi-mi:ccdA(display_short)|uniprotkb:H(gene name synonym)|uniprotkb:letA(gene name synonym)|uniprotkb:ECOK12F042(locus name)|uniprotkb:LynA(gene name synonym)|uniprotkb:Protein H(gene name synonym)|uniprotkb:Protein LetA(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	De et al. (2009)	imex:IM-28247|pubmed:19647513	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-25647822|imex:IM-28247-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_416734.1|refseq:WP_001281242.1|ensemblbacteria:AAC75291(transcript)|ensemblbacteria:b2231(gene)|ensemblbacteria:BAA16048(gene)|ensemblbacteria:BAA16048(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0006265"(DNA topological change)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0009330"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex")|go:"GO:0016020"(membrane)|go:"GO:0034335"(DNA negative supercoiling activity)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0046677"(response to antibiotic)|interpro:IPR002205(DNA topoisomerase, type IIA, subunit A or C-terminal)|interpro:IPR005743(DNA gyrase, subunit A)|interpro:IPR006691(DNA gyrase/topoisomerase IV, subunit A, C-terminal beta-pinwheel)|interpro:IPR013760(DNA topoisomerase, type IIA, central)|interpro:IPR035516|rcsb pdb:1AB4|rcsb pdb:1X75|rcsb pdb:1ZI0|rcsb pdb:2Y3P|rcsb pdb:3NUH|rcsb pdb:4ELY|rcsb pdb:6RKS|rcsb pdb:6RKU|rcsb pdb:6RKV|rcsb pdb:6RKW|dip:DIP-36179N	go:"GO:0003677"(DNA binding)|refseq:NP_061421.1|refseq:WP_000813634.1|refseq:YP_001816480.1|refseq:YP_003108266.1|refseq:YP_003162544.1|refseq:YP_003829105.1|refseq:YP_003829230.1|refseq:YP_006940499.1|refseq:YP_424850.1|refseq:YP_788019.1|rcsb pdb:2ADL|rcsb pdb:2ADN|rcsb pdb:2H3A|rcsb pdb:2H3C|rcsb pdb:3G7Z|rcsb pdb:3HPW|interpro:IPR009956(Post-segregation antitoxin CcdA)	-	-	-	figure legend:Fig. 3A,3B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/06/15	2020/06/15	rogid:O5WW4A/0lHpHyyIaahw9PQkc/Ug83333	rogid:NFxGRso8ws1Le8CdtjsAr4O3krE83333	rigid:DPW1lmbXdW0fbTBZeGcuUzaMhyI	false	sufficient binding region:2-253|his tag:n-n	sufficient binding region:65-72	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P62554	uniprotkb:P0AES4	intact:EBI-25647730|uniprotkb:P05703	intact:EBI-547129|uniprotkb:P09097|ensemblbacteria:AAC75291|ensemblbacteria:BAA16048	psi-mi:ccdb_ecoli(display_long)|uniprotkb:ccdB(gene name)|psi-mi:ccdB(display_short)|uniprotkb:G(gene name synonym)|uniprotkb:letB(gene name synonym)|uniprotkb:letD(gene name synonym)|uniprotkb:ECOK12F043(locus name)|uniprotkb:Cytotoxic protein CcdB(gene name synonym)|uniprotkb:LynB(gene name synonym)|uniprotkb:Protein G(gene name synonym)|uniprotkb:Protein LetD(gene name synonym)	psi-mi:gyra_ecoli(display_long)|uniprotkb:hisW(gene name synonym)|uniprotkb:nalA(gene name synonym)|uniprotkb:parD(gene name synonym)|uniprotkb:b2231(locus name)|uniprotkb:gyrA(gene name)|psi-mi:gyrA(display_short)|uniprotkb:JW2225(locus name)	psi-mi:"MI:0071"(molecular sieving)	De et al. (2009)	imex:IM-28247|pubmed:19647513	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-25647838|imex:IM-28247-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0006276"(plasmid maintenance)|go:"GO:0008657"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity")|refseq:NP_061422.1|refseq:WP_001159868.1|refseq:YP_003108267.1|rcsb pdb:1VUB|rcsb pdb:1X75|rcsb pdb:2VUB|rcsb pdb:3G7Z|rcsb pdb:3HPW|rcsb pdb:3VUB|rcsb pdb:4VUB|interpro:IPR002712(CcdB protein)|interpro:IPR011067(Plasmid maintenance toxin/Cell growth inhibitor)	refseq:NP_416734.1|refseq:WP_001281242.1|ensemblbacteria:AAC75291(transcript)|ensemblbacteria:b2231(gene)|ensemblbacteria:BAA16048(gene)|ensemblbacteria:BAA16048(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0006265"(DNA topological change)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0009330"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex")|go:"GO:0016020"(membrane)|go:"GO:0034335"(DNA negative supercoiling activity)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0046677"(response to antibiotic)|interpro:IPR002205(DNA topoisomerase, type IIA, subunit A or C-terminal)|interpro:IPR005743(DNA gyrase, subunit A)|interpro:IPR006691(DNA gyrase/topoisomerase IV, subunit A, C-terminal beta-pinwheel)|interpro:IPR013760(DNA topoisomerase, type IIA, central)|interpro:IPR035516|rcsb pdb:1AB4|rcsb pdb:1X75|rcsb pdb:1ZI0|rcsb pdb:2Y3P|rcsb pdb:3NUH|rcsb pdb:4ELY|rcsb pdb:6RKS|rcsb pdb:6RKU|rcsb pdb:6RKV|rcsb pdb:6RKW|dip:DIP-36179N	-	-	-	figure legend:Fig.3C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/06/15	2020/06/15	rogid:VI6U/gzKwdl+WPL2FxAigN49i4o83333	rogid:O5WW4A/0lHpHyyIaahw9PQkc/Ug83333	rigid:H0oO9UVwGAj3rrFtzlVJNgypMmg	false	-	sufficient binding region:2-253|his tag:n-n	2	2	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:P0AES4	uniprotkb:P0AES4	intact:EBI-547129|uniprotkb:P09097|ensemblbacteria:AAC75291|ensemblbacteria:BAA16048	intact:EBI-547129|uniprotkb:P09097|ensemblbacteria:AAC75291|ensemblbacteria:BAA16048	psi-mi:gyra_ecoli(display_long)|uniprotkb:hisW(gene name synonym)|uniprotkb:nalA(gene name synonym)|uniprotkb:parD(gene name synonym)|uniprotkb:b2231(locus name)|uniprotkb:gyrA(gene name)|psi-mi:gyrA(display_short)|uniprotkb:JW2225(locus name)	psi-mi:gyra_ecoli(display_long)|uniprotkb:hisW(gene name synonym)|uniprotkb:nalA(gene name synonym)|uniprotkb:parD(gene name synonym)|uniprotkb:b2231(locus name)|uniprotkb:gyrA(gene name)|psi-mi:gyrA(display_short)|uniprotkb:JW2225(locus name)	psi-mi:"MI:0071"(molecular sieving)	De et al. (2009)	imex:IM-28247|pubmed:19647513	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-25647854|imex:IM-28247-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_416734.1|refseq:WP_001281242.1|ensemblbacteria:AAC75291(transcript)|ensemblbacteria:b2231(gene)|ensemblbacteria:BAA16048(gene)|ensemblbacteria:BAA16048(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0006265"(DNA topological change)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0009330"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex")|go:"GO:0016020"(membrane)|go:"GO:0034335"(DNA negative supercoiling activity)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0046677"(response to antibiotic)|interpro:IPR002205(DNA topoisomerase, type IIA, subunit A or C-terminal)|interpro:IPR005743(DNA gyrase, subunit A)|interpro:IPR006691(DNA gyrase/topoisomerase IV, subunit A, C-terminal beta-pinwheel)|interpro:IPR013760(DNA topoisomerase, type IIA, central)|interpro:IPR035516|rcsb pdb:1AB4|rcsb pdb:1X75|rcsb pdb:1ZI0|rcsb pdb:2Y3P|rcsb pdb:3NUH|rcsb pdb:4ELY|rcsb pdb:6RKS|rcsb pdb:6RKU|rcsb pdb:6RKV|rcsb pdb:6RKW|dip:DIP-36179N	refseq:NP_416734.1|refseq:WP_001281242.1|ensemblbacteria:AAC75291(transcript)|ensemblbacteria:b2231(gene)|ensemblbacteria:BAA16048(gene)|ensemblbacteria:BAA16048(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0006265"(DNA topological change)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0009330"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex")|go:"GO:0016020"(membrane)|go:"GO:0034335"(DNA negative supercoiling activity)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0046677"(response to antibiotic)|interpro:IPR002205(DNA topoisomerase, type IIA, subunit A or C-terminal)|interpro:IPR005743(DNA gyrase, subunit A)|interpro:IPR006691(DNA gyrase/topoisomerase IV, subunit A, C-terminal beta-pinwheel)|interpro:IPR013760(DNA topoisomerase, type IIA, central)|interpro:IPR035516|rcsb pdb:1AB4|rcsb pdb:1X75|rcsb pdb:1ZI0|rcsb pdb:2Y3P|rcsb pdb:3NUH|rcsb pdb:4ELY|rcsb pdb:6RKS|rcsb pdb:6RKU|rcsb pdb:6RKV|rcsb pdb:6RKW|dip:DIP-36179N	-	-	-	figure legend:Fig.3C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/06/15	2020/06/15	rogid:O5WW4A/0lHpHyyIaahw9PQkc/Ug83333	rogid:O5WW4A/0lHpHyyIaahw9PQkc/Ug83333	rigid:Utg4G1mMjCPFMSoWk7Nnx1bK7M4	false	sufficient binding region:2-253|his tag:n-n	sufficient binding region:2-253|his tag:n-n	2	0	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:P62554	uniprotkb:P62552	intact:EBI-25647730|uniprotkb:P05703	intact:EBI-25647704|uniprotkb:P05702	psi-mi:ccdb_ecoli(display_long)|uniprotkb:ccdB(gene name)|psi-mi:ccdB(display_short)|uniprotkb:G(gene name synonym)|uniprotkb:letB(gene name synonym)|uniprotkb:letD(gene name synonym)|uniprotkb:ECOK12F043(locus name)|uniprotkb:Cytotoxic protein CcdB(gene name synonym)|uniprotkb:LynB(gene name synonym)|uniprotkb:Protein G(gene name synonym)|uniprotkb:Protein LetD(gene name synonym)	psi-mi:ccda_ecoli(display_long)|uniprotkb:ccdA(gene name)|psi-mi:ccdA(display_short)|uniprotkb:H(gene name synonym)|uniprotkb:letA(gene name synonym)|uniprotkb:ECOK12F042(locus name)|uniprotkb:LynA(gene name synonym)|uniprotkb:Protein H(gene name synonym)|uniprotkb:Protein LetA(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	De et al. (2009)	imex:IM-28247|pubmed:19647513	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26447340|imex:IM-28247-18	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0006276"(plasmid maintenance)|go:"GO:0008657"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity")|refseq:NP_061422.1|refseq:WP_001159868.1|refseq:YP_003108267.1|rcsb pdb:1VUB|rcsb pdb:1X75|rcsb pdb:2VUB|rcsb pdb:3G7Z|rcsb pdb:3HPW|rcsb pdb:3VUB|rcsb pdb:4VUB|interpro:IPR002712(CcdB protein)|interpro:IPR011067(Plasmid maintenance toxin/Cell growth inhibitor)	go:"GO:0003677"(DNA binding)|refseq:NP_061421.1|refseq:WP_000813634.1|refseq:YP_001816480.1|refseq:YP_003108266.1|refseq:YP_003162544.1|refseq:YP_003829105.1|refseq:YP_003829230.1|refseq:YP_006940499.1|refseq:YP_424850.1|refseq:YP_788019.1|rcsb pdb:2ADL|rcsb pdb:2ADN|rcsb pdb:2H3A|rcsb pdb:2H3C|rcsb pdb:3G7Z|rcsb pdb:3HPW|interpro:IPR009956(Post-segregation antitoxin CcdA)	-	-	-	figure legend:Fig. 3C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/06/15	2020/11/16	rogid:VI6U/gzKwdl+WPL2FxAigN49i4o83333	rogid:NFxGRso8ws1Le8CdtjsAr4O3krE83333	rigid:aKp0DnIc6YR66p7OZUgO4MSH2gg	false	-	sufficient binding region:37-72	2	1	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:P62554	uniprotkb:P62552	intact:EBI-25647730|uniprotkb:P05703	intact:EBI-25647704|uniprotkb:P05702	psi-mi:ccdb_ecoli(display_long)|uniprotkb:ccdB(gene name)|psi-mi:ccdB(display_short)|uniprotkb:G(gene name synonym)|uniprotkb:letB(gene name synonym)|uniprotkb:letD(gene name synonym)|uniprotkb:ECOK12F043(locus name)|uniprotkb:Cytotoxic protein CcdB(gene name synonym)|uniprotkb:LynB(gene name synonym)|uniprotkb:Protein G(gene name synonym)|uniprotkb:Protein LetD(gene name synonym)	psi-mi:ccda_ecoli(display_long)|uniprotkb:ccdA(gene name)|psi-mi:ccdA(display_short)|uniprotkb:H(gene name synonym)|uniprotkb:letA(gene name synonym)|uniprotkb:ECOK12F042(locus name)|uniprotkb:LynA(gene name synonym)|uniprotkb:Protein H(gene name synonym)|uniprotkb:Protein LetA(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	De et al. (2009)	imex:IM-28247|pubmed:19647513	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-25647780|imex:IM-28247-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0006276"(plasmid maintenance)|go:"GO:0008657"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity")|refseq:NP_061422.1|refseq:WP_001159868.1|refseq:YP_003108267.1|rcsb pdb:1VUB|rcsb pdb:1X75|rcsb pdb:2VUB|rcsb pdb:3G7Z|rcsb pdb:3HPW|rcsb pdb:3VUB|rcsb pdb:4VUB|interpro:IPR002712(CcdB protein)|interpro:IPR011067(Plasmid maintenance toxin/Cell growth inhibitor)	go:"GO:0003677"(DNA binding)|refseq:NP_061421.1|refseq:WP_000813634.1|refseq:YP_001816480.1|refseq:YP_003108266.1|refseq:YP_003162544.1|refseq:YP_003829105.1|refseq:YP_003829230.1|refseq:YP_006940499.1|refseq:YP_424850.1|refseq:YP_788019.1|rcsb pdb:2ADL|rcsb pdb:2ADN|rcsb pdb:2H3A|rcsb pdb:2H3C|rcsb pdb:3G7Z|rcsb pdb:3HPW|interpro:IPR009956(Post-segregation antitoxin CcdA)	-	-	-	figure legend:Fig. 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/06/15	2020/06/15	rogid:VI6U/gzKwdl+WPL2FxAigN49i4o83333	rogid:NFxGRso8ws1Le8CdtjsAr4O3krE83333	rigid:aKp0DnIc6YR66p7OZUgO4MSH2gg	false	-	sufficient binding region:40-61|sufficient binding region:37-72	2	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P62552	uniprotkb:P62554	intact:EBI-25647704|uniprotkb:P05702	intact:EBI-25647730|uniprotkb:P05703	psi-mi:ccda_ecoli(display_long)|uniprotkb:ccdA(gene name)|psi-mi:ccdA(display_short)|uniprotkb:H(gene name synonym)|uniprotkb:letA(gene name synonym)|uniprotkb:ECOK12F042(locus name)|uniprotkb:LynA(gene name synonym)|uniprotkb:Protein H(gene name synonym)|uniprotkb:Protein LetA(gene name synonym)	psi-mi:ccdb_ecoli(display_long)|uniprotkb:ccdB(gene name)|psi-mi:ccdB(display_short)|uniprotkb:G(gene name synonym)|uniprotkb:letB(gene name synonym)|uniprotkb:letD(gene name synonym)|uniprotkb:ECOK12F043(locus name)|uniprotkb:Cytotoxic protein CcdB(gene name synonym)|uniprotkb:LynB(gene name synonym)|uniprotkb:Protein G(gene name synonym)|uniprotkb:Protein LetD(gene name synonym)	psi-mi:"MI:0016"(circular dichroism)	De et al. (2009)	imex:IM-28247|pubmed:19647513	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-25647846|imex:IM-28247-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0003677"(DNA binding)|refseq:NP_061421.1|refseq:WP_000813634.1|refseq:YP_001816480.1|refseq:YP_003108266.1|refseq:YP_003162544.1|refseq:YP_003829105.1|refseq:YP_003829230.1|refseq:YP_006940499.1|refseq:YP_424850.1|refseq:YP_788019.1|rcsb pdb:2ADL|rcsb pdb:2ADN|rcsb pdb:2H3A|rcsb pdb:2H3C|rcsb pdb:3G7Z|rcsb pdb:3HPW|interpro:IPR009956(Post-segregation antitoxin CcdA)	go:"GO:0006276"(plasmid maintenance)|go:"GO:0008657"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity")|refseq:NP_061422.1|refseq:WP_001159868.1|refseq:YP_003108267.1|rcsb pdb:1VUB|rcsb pdb:1X75|rcsb pdb:2VUB|rcsb pdb:3G7Z|rcsb pdb:3HPW|rcsb pdb:3VUB|rcsb pdb:4VUB|interpro:IPR002712(CcdB protein)|interpro:IPR011067(Plasmid maintenance toxin/Cell growth inhibitor)	-	-	-	figure legend:Supp Fig 4B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/06/15	2020/11/16	rogid:NFxGRso8ws1Le8CdtjsAr4O3krE83333	rogid:VI6U/gzKwdl+WPL2FxAigN49i4o83333	rigid:aKp0DnIc6YR66p7OZUgO4MSH2gg	false	sufficient binding region:37-72	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)