#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q07021	uniprotkb:Q15672	intact:EBI-347528|uniprotkb:Q2HXR8|uniprotkb:Q9NNY8|intact:EBI-15990352|ensembl:ENSP00000225698	intact:EBI-1797287|uniprotkb:Q92487|uniprotkb:Q99804|uniprotkb:A4D128|ensembl:ENSP00000242261	psi-mi:c1qbp_human(display_long)|uniprotkb:C1QBP(gene name)|psi-mi:C1QBP(display_short)|uniprotkb:GC1QBP(gene name synonym)|uniprotkb:HABP1(gene name synonym)|uniprotkb:SF2P32(gene name synonym)|uniprotkb:Glycoprotein gC1qBP(gene name synonym)|uniprotkb:Hyaluronan-binding protein 1(gene name synonym)|uniprotkb:Mitochondrial matrix protein p32(gene name synonym)|uniprotkb:p33(gene name synonym)|uniprotkb:ASF/SF2-associated protein p32(gene name synonym)|uniprotkb:gC1q-R protein(gene name synonym)	psi-mi:twst1_human(display_long)|uniprotkb:H-twist(gene name synonym)|uniprotkb:TWIST1(gene name)|psi-mi:TWIST1(display_short)|uniprotkb:TWIST(gene name synonym)|uniprotkb:BHLHA38(gene name synonym)|uniprotkb:Class A basic helix-loop-helix protein 38(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Singh et al. (2009)	imex:IM-28326|pubmed:19534813	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25824677|imex:IM-28326-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001203.1|dip:DIP-31164N|ensembl:ENSG00000108561(gene)|ensembl:ENST00000225698(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005540"(hyaluronic acid binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006397"(mRNA processing)|go:"GO:0006915"(apoptotic process)|go:"GO:0006955"(immune response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0008494"(translation activator activity)|go:"GO:0009986"(cell surface)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0030449"(regulation of complement activation)|go:"GO:0030984"(kininogen binding)|go:"GO:0031690"(adrenergic receptor binding)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0039534"(negative regulation of MDA-5 signaling pathway)|go:"GO:0039536"(negative regulation of RIG-I signaling pathway)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0042256"(mature ribosome assembly)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050687"(negative regulation of defense response to virus)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070131"(positive regulation of mitochondrial translation)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0097177"(mitochondrial ribosome binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:2000510"(positive regulation of dendritic cell chemotaxis)|interpro:IPR003428(Mitochondrial glycoprotein)|interpro:IPR036561|mint:Q07021|rcsb pdb:1P32|rcsb pdb:3RPX|rcsb pdb:6SZW|reactome:R-HSA-111471|go:"GO:0005886"(plasma membrane)|reactome:R-HSA-8980692|reactome:R-HSA-9013106|reactome:R-HSA-9645722|reactome:R-HSA-140837	refseq:NP_000465.1|refseq:XP_011513798.1|dip:DIP-45974N|ensembl:ENSG00000122691(gene)|ensembl:ENST00000242261(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001503"(ossification)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001764"(neuron migration)|go:"GO:0001843"(neural tube closure)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003253"(cardiac neural crest cell migration involved in outflow tract morphogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007517"(muscle organ development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030500"(regulation of bone mineralization)|go:"GO:0032000"(positive regulation of fatty acid beta-oxidation)|go:"GO:0032502"(developmental process)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033128"(negative regulation of histone phosphorylation)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035359"(negative regulation of peroxisome proliferator activated receptor signaling pathway)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042476"(odontogenesis)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048511"(rhythmic process)|go:"GO:0048642"(negative regulation of skeletal muscle tissue development)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060363"(cranial suture morphogenesis)|go:"GO:0060900"(embryonic camera-type eye formation)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0070888"(E-box binding)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:2000144"(positive regulation of DNA-templated transcription, initiation)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000276"(negative regulation of oxidative phosphorylation uncoupler activity)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:2000780"(negative regulation of double-strand break repair)|go:"GO:2000793"(cell proliferation involved in heart valve development)|go:"GO:2000802"(positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR015789(Twist)|interpro:IPR036638|rcsb pdb:2MJV|reactome:R-HSA-6785807|reactome:R-HSA-8878166|reactome:R-HSA-8939902	-	-	-	figure legend:Table 2|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/09/08	2020/09/08	rogid:NfZ31HjbYZxd8UQKRXczhpc306E9606	rogid:1+WEEh0ruAAKCxlJQCVzBqTrhIM9606	rigid:eL7rOT5reWiUN+jhRNkZ6g8JD1U	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P15884	uniprotkb:Q15672	intact:EBI-533224|uniprotkb:Q08AP3|uniprotkb:Q08AP2|uniprotkb:Q15440|uniprotkb:Q15441|uniprotkb:Q15439|uniprotkb:B4DT37|ensembl:ENSP00000348374|ensembl:ENSP00000457649|uniprotkb:G0LNT9|uniprotkb:G0LNU0|uniprotkb:G0LNU1|uniprotkb:G0LNU2|uniprotkb:G0LNU8|uniprotkb:G0LNU9|uniprotkb:G0LNV0|uniprotkb:G0LNV1|uniprotkb:B3KT62|uniprotkb:B3KUC0|uniprotkb:B4DUG3|uniprotkb:B7Z5M6|uniprotkb:G0LNU5|uniprotkb:H3BPQ1|uniprotkb:B7Z6Y1|uniprotkb:G0LNU4|uniprotkb:G0LNV2	intact:EBI-1797287|uniprotkb:Q92487|uniprotkb:Q99804|uniprotkb:A4D128|ensembl:ENSP00000242261	psi-mi:itf2_human(display_long)|uniprotkb:Immunoglobulin transcription factor 2(gene name synonym)|uniprotkb:SL3-3 enhancer factor 2(gene name synonym)|uniprotkb:ITF2(gene name synonym)|uniprotkb:SEF2(gene name synonym)|uniprotkb:TCF4(gene name)|psi-mi:TCF4(display_short)|uniprotkb:BHLHB19(gene name synonym)|uniprotkb:Class B basic helix-loop-helix protein 19(gene name synonym)	psi-mi:twst1_human(display_long)|uniprotkb:H-twist(gene name synonym)|uniprotkb:TWIST1(gene name)|psi-mi:TWIST1(display_short)|uniprotkb:TWIST(gene name synonym)|uniprotkb:BHLHA38(gene name synonym)|uniprotkb:Class A basic helix-loop-helix protein 38(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Singh et al. (2009)	imex:IM-28326|pubmed:19534813	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25824689|imex:IM-28326-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001230155.2|refseq:NP_001077431.1|refseq:NP_001230163.1|refseq:NP_003190.1|refseq:XP_005266796.2|ensembl:ENSG00000196628(gene)|ensembl:ENST00000356073(transcript)|ensembl:ENST00000564999(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001093"(TFIIB-class transcription factor binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0065004"(protein-DNA complex assembly)|go:"GO:0070369"(beta-catenin-TCF7L2 complex)|go:"GO:0070888"(E-box binding)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990907"(beta-catenin-TCF complex)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|mint:P15884|rcsb pdb:2KWF|rcsb pdb:6OD3|rcsb pdb:6OD4|rcsb pdb:6OD5|reactome:R-HSA-525793|refseq:NP_001335140.1|refseq:NP_001335141.1|refseq:NP_001335142.1|refseq:NP_001335143.1|refseq:NP_001335144.1|refseq:NP_001335145.1|refseq:NP_001335146.1|refseq:NP_001335147.1|refseq:NP_001335148.1|refseq:NP_001335149.1|refseq:NP_001293136.1|refseq:NP_001293137.1|refseq:NP_001230164.1|refseq:NP_001230165.1|refseq:NP_001230160.1|refseq:NP_001230161.1|refseq:NP_001230162.1|refseq:XP_006722599.1|refseq:XP_006722600.1|refseq:NP_001230156.1|refseq:NP_001230157.1|refseq:NP_001230159.1|refseq:XP_016881425.1|refseq:XP_016881429.1|refseq:XP_016881430.1|refseq:XP_016881435.1|refseq:XP_016881445.1|dip:DIP-163N	refseq:NP_000465.1|refseq:XP_011513798.1|dip:DIP-45974N|ensembl:ENSG00000122691(gene)|ensembl:ENST00000242261(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001503"(ossification)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001764"(neuron migration)|go:"GO:0001843"(neural tube closure)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003253"(cardiac neural crest cell migration involved in outflow tract morphogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007517"(muscle organ development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030500"(regulation of bone mineralization)|go:"GO:0032000"(positive regulation of fatty acid beta-oxidation)|go:"GO:0032502"(developmental process)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033128"(negative regulation of histone phosphorylation)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035359"(negative regulation of peroxisome proliferator activated receptor signaling pathway)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042476"(odontogenesis)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048511"(rhythmic process)|go:"GO:0048642"(negative regulation of skeletal muscle tissue development)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060363"(cranial suture morphogenesis)|go:"GO:0060900"(embryonic camera-type eye formation)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0070888"(E-box binding)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:2000144"(positive regulation of DNA-templated transcription, initiation)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000276"(negative regulation of oxidative phosphorylation uncoupler activity)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:2000780"(negative regulation of double-strand break repair)|go:"GO:2000793"(cell proliferation involved in heart valve development)|go:"GO:2000802"(positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR015789(Twist)|interpro:IPR036638|rcsb pdb:2MJV|reactome:R-HSA-6785807|reactome:R-HSA-8878166|reactome:R-HSA-8939902	-	-	-	figure legend:Table 2|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/09/08	2020/09/08	rogid:5ofdcOZrL/NXfVfFMVO8GMyh+ZY9606	rogid:1+WEEh0ruAAKCxlJQCVzBqTrhIM9606	rigid:gZ8sJlsm/MnGOTxAtHPCsbYNdv4	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q96B67	uniprotkb:Q15672	intact:EBI-2875665|intact:EBI-28982382|ensembl:ENSP00000265138|uniprotkb:A8K6T8|uniprotkb:Q9P2H1	intact:EBI-1797287|uniprotkb:Q92487|uniprotkb:Q99804|uniprotkb:A4D128|ensembl:ENSP00000242261	psi-mi:arrd3_human(display_long)|uniprotkb:KIAA1376(gene name synonym)|uniprotkb:TBP-2-like inducible membrane protein(gene name synonym)|uniprotkb:ARRDC3(gene name)|psi-mi:ARRDC3(display_short)	psi-mi:twst1_human(display_long)|uniprotkb:H-twist(gene name synonym)|uniprotkb:TWIST1(gene name)|psi-mi:TWIST1(display_short)|uniprotkb:TWIST(gene name synonym)|uniprotkb:BHLHA38(gene name synonym)|uniprotkb:Class A basic helix-loop-helix protein 38(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Singh et al. (2009)	imex:IM-28326|pubmed:19534813	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25824694|imex:IM-28326-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000113369(gene)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0015031"(protein transport)|go:"GO:0031651"(negative regulation of heat generation)|go:"GO:0031699"(beta-3 adrenergic receptor binding)|go:"GO:0043588"(skin development)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060613"(fat pad development)|go:"GO:0071878"(negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0090327"(negative regulation of locomotion involved in locomotory behavior)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014756(Immunoglobulin E-set)|rcsb pdb:4N7H|rcsb pdb:4R7V|rcsb pdb:4R7X|ensembl:ENST00000265138(transcript)|refseq:NP_065852.1|ensembl:ENSP00000265138	refseq:NP_000465.1|refseq:XP_011513798.1|dip:DIP-45974N|ensembl:ENSG00000122691(gene)|ensembl:ENST00000242261(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001503"(ossification)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001764"(neuron migration)|go:"GO:0001843"(neural tube closure)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003253"(cardiac neural crest cell migration involved in outflow tract morphogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007517"(muscle organ development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030500"(regulation of bone mineralization)|go:"GO:0032000"(positive regulation of fatty acid beta-oxidation)|go:"GO:0032502"(developmental process)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033128"(negative regulation of histone phosphorylation)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035359"(negative regulation of peroxisome proliferator activated receptor signaling pathway)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042476"(odontogenesis)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048511"(rhythmic process)|go:"GO:0048642"(negative regulation of skeletal muscle tissue development)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060363"(cranial suture morphogenesis)|go:"GO:0060900"(embryonic camera-type eye formation)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0070888"(E-box binding)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:2000144"(positive regulation of DNA-templated transcription, initiation)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000276"(negative regulation of oxidative phosphorylation uncoupler activity)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:2000780"(negative regulation of double-strand break repair)|go:"GO:2000793"(cell proliferation involved in heart valve development)|go:"GO:2000802"(positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR015789(Twist)|interpro:IPR036638|rcsb pdb:2MJV|reactome:R-HSA-6785807|reactome:R-HSA-8878166|reactome:R-HSA-8939902	-	-	-	figure legend:Table 2|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/09/08	2020/09/08	rogid:XPgatMsOEeWbHJXTkQZsNXaWuNs9606	rogid:1+WEEh0ruAAKCxlJQCVzBqTrhIM9606	rigid:wvc26R6kQ4lL5Ngp52OAqggPTPY	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P10909	uniprotkb:Q15672	intact:EBI-1104674|uniprotkb:B3KSE6|uniprotkb:P11380|uniprotkb:P11381|uniprotkb:Q5HYC1|uniprotkb:Q7Z5B9|uniprotkb:B2R9Q1|uniprotkb:Q2TU75|ensembl:ENSP00000315130|ensembl:ENSP00000385419|ensembl:ENSP00000429620	intact:EBI-1797287|uniprotkb:Q92487|uniprotkb:Q99804|uniprotkb:A4D128|ensembl:ENSP00000242261	psi-mi:clus_human(display_long)|uniprotkb:CLU(gene name)|psi-mi:CLU(display_short)|uniprotkb:APOJ(gene name synonym)|uniprotkb:CLI(gene name synonym)|uniprotkb:KUB1(gene name synonym)|uniprotkb:Complement-associated protein SP-40,40(gene name synonym)|uniprotkb:Complement cytolysis inhibitor(gene name synonym)|uniprotkb:NA1/NA2(gene name synonym)|uniprotkb:Apolipoprotein J(gene name synonym)|uniprotkb:Testosterone-repressed prostate message 2(gene name synonym)|uniprotkb:Ku70-binding protein 1(gene name synonym)|uniprotkb:Aging-associated gene 4 protein(gene name synonym)|uniprotkb:AAG4(orf name)|uniprotkb:Sulfated glycoprotein 2(gene name synonym)	psi-mi:twst1_human(display_long)|uniprotkb:H-twist(gene name synonym)|uniprotkb:TWIST1(gene name)|psi-mi:TWIST1(display_short)|uniprotkb:TWIST(gene name synonym)|uniprotkb:BHLHA38(gene name synonym)|uniprotkb:Class A basic helix-loop-helix protein 38(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Singh et al. (2009)	imex:IM-28326|pubmed:19534813	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25824698|imex:IM-28326-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0006629"(lipid metabolic process)|go:"GO:0006956"(complement activation)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0009615"(response to virus)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0017038"(protein import)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032286"(central nervous system myelin maintenance)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0005829"(cytosol)|ensembl:ENSG00000120885(gene)|ensembl:ENST00000316403(transcript)|ensembl:ENST00000405140(transcript)|ensembl:ENST00000523500(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0002434"(immune complex clearance)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0034366"(spherical high-density lipoprotein particle)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042583"(chromaffin granule)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043691"(reverse cholesterol transport)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045202"(synapse)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048156"(tau protein binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0051788"(response to misfolded protein)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:0061740"(protein targeting to lysosome involved in chaperone-mediated autophagy)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0097418"(neurofibrillary tangle)|go:"GO:0097440"(apical dendrite)|go:"GO:0099020"(perinuclear endoplasmic reticulum lumen)|go:"GO:0140597"(protein carrier chaperone)|go:"GO:1900221"(regulation of amyloid-beta clearance)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902847"(regulation of neuronal signal transduction)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1902998"(positive regulation of neurofibrillary tangle assembly)|go:"GO:1903573"(negative regulation of response to endoplasmic reticulum stress)|go:"GO:1905892"(negative regulation of cellular response to thapsigargin)|go:"GO:1905895"(negative regulation of cellular response to tunicamycin)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:1905908"(positive regulation of amyloid fibril formation)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000753(Clusterin-like)|interpro:IPR016014(Clusterin, N-terminal)|interpro:IPR016015(Clusterin, C-terminal)|interpro:IPR016016(Clusterin)|interpro:IPR033986|mint:P10909|reactome:R-HSA-114608|reactome:R-HSA-166665|reactome:R-HSA-6803157|go:"GO:0060548"(negative regulation of cell death)|reactome:R-HSA-977606|refseq:NP_001822.3|dip:DIP-37546N	refseq:NP_000465.1|refseq:XP_011513798.1|dip:DIP-45974N|ensembl:ENSG00000122691(gene)|ensembl:ENST00000242261(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001503"(ossification)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001764"(neuron migration)|go:"GO:0001843"(neural tube closure)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003253"(cardiac neural crest cell migration involved in outflow tract morphogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007517"(muscle organ development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030500"(regulation of bone mineralization)|go:"GO:0032000"(positive regulation of fatty acid beta-oxidation)|go:"GO:0032502"(developmental process)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033128"(negative regulation of histone phosphorylation)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035359"(negative regulation of peroxisome proliferator activated receptor signaling pathway)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042476"(odontogenesis)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048511"(rhythmic process)|go:"GO:0048642"(negative regulation of skeletal muscle tissue development)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060363"(cranial suture morphogenesis)|go:"GO:0060900"(embryonic camera-type eye formation)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0070888"(E-box binding)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:2000144"(positive regulation of DNA-templated transcription, initiation)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000276"(negative regulation of oxidative phosphorylation uncoupler activity)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:2000780"(negative regulation of double-strand break repair)|go:"GO:2000793"(cell proliferation involved in heart valve development)|go:"GO:2000802"(positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR015789(Twist)|interpro:IPR036638|rcsb pdb:2MJV|reactome:R-HSA-6785807|reactome:R-HSA-8878166|reactome:R-HSA-8939902	-	-	-	figure legend:Table 2|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2020/09/08	2020/09/08	rogid:qlCJp4zYTklC3YZNQvbLmZBiz4U9606	rogid:1+WEEh0ruAAKCxlJQCVzBqTrhIM9606	rigid:9X37MWqZ0Dt9rcHHo50hZ64cEW0	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P15884	uniprotkb:Q15672	intact:EBI-533224|uniprotkb:Q08AP3|uniprotkb:Q08AP2|uniprotkb:Q15440|uniprotkb:Q15441|uniprotkb:Q15439|uniprotkb:B4DT37|ensembl:ENSP00000348374|ensembl:ENSP00000457649|uniprotkb:G0LNT9|uniprotkb:G0LNU0|uniprotkb:G0LNU1|uniprotkb:G0LNU2|uniprotkb:G0LNU8|uniprotkb:G0LNU9|uniprotkb:G0LNV0|uniprotkb:G0LNV1|uniprotkb:B3KT62|uniprotkb:B3KUC0|uniprotkb:B4DUG3|uniprotkb:B7Z5M6|uniprotkb:G0LNU5|uniprotkb:H3BPQ1|uniprotkb:B7Z6Y1|uniprotkb:G0LNU4|uniprotkb:G0LNV2	intact:EBI-1797287|uniprotkb:Q92487|uniprotkb:Q99804|uniprotkb:A4D128|ensembl:ENSP00000242261	psi-mi:itf2_human(display_long)|uniprotkb:Immunoglobulin transcription factor 2(gene name synonym)|uniprotkb:SL3-3 enhancer factor 2(gene name synonym)|uniprotkb:ITF2(gene name synonym)|uniprotkb:SEF2(gene name synonym)|uniprotkb:TCF4(gene name)|psi-mi:TCF4(display_short)|uniprotkb:BHLHB19(gene name synonym)|uniprotkb:Class B basic helix-loop-helix protein 19(gene name synonym)	psi-mi:twst1_human(display_long)|uniprotkb:H-twist(gene name synonym)|uniprotkb:TWIST1(gene name)|psi-mi:TWIST1(display_short)|uniprotkb:TWIST(gene name synonym)|uniprotkb:BHLHA38(gene name synonym)|uniprotkb:Class A basic helix-loop-helix protein 38(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Singh et al. (2009)	imex:IM-28326|pubmed:19534813	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25824719|imex:IM-28326-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001230155.2|refseq:NP_001077431.1|refseq:NP_001230163.1|refseq:NP_003190.1|refseq:XP_005266796.2|ensembl:ENSG00000196628(gene)|ensembl:ENST00000356073(transcript)|ensembl:ENST00000564999(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001093"(TFIIB-class transcription factor binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0065004"(protein-DNA complex assembly)|go:"GO:0070369"(beta-catenin-TCF7L2 complex)|go:"GO:0070888"(E-box binding)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990907"(beta-catenin-TCF complex)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|mint:P15884|rcsb pdb:2KWF|rcsb pdb:6OD3|rcsb pdb:6OD4|rcsb pdb:6OD5|reactome:R-HSA-525793|refseq:NP_001335140.1|refseq:NP_001335141.1|refseq:NP_001335142.1|refseq:NP_001335143.1|refseq:NP_001335144.1|refseq:NP_001335145.1|refseq:NP_001335146.1|refseq:NP_001335147.1|refseq:NP_001335148.1|refseq:NP_001335149.1|refseq:NP_001293136.1|refseq:NP_001293137.1|refseq:NP_001230164.1|refseq:NP_001230165.1|refseq:NP_001230160.1|refseq:NP_001230161.1|refseq:NP_001230162.1|refseq:XP_006722599.1|refseq:XP_006722600.1|refseq:NP_001230156.1|refseq:NP_001230157.1|refseq:NP_001230159.1|refseq:XP_016881425.1|refseq:XP_016881429.1|refseq:XP_016881430.1|refseq:XP_016881435.1|refseq:XP_016881445.1|dip:DIP-163N	refseq:NP_000465.1|refseq:XP_011513798.1|dip:DIP-45974N|ensembl:ENSG00000122691(gene)|ensembl:ENST00000242261(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001503"(ossification)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001764"(neuron migration)|go:"GO:0001843"(neural tube closure)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003253"(cardiac neural crest cell migration involved in outflow tract morphogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007517"(muscle organ development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030500"(regulation of bone mineralization)|go:"GO:0032000"(positive regulation of fatty acid beta-oxidation)|go:"GO:0032502"(developmental process)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033128"(negative regulation of histone phosphorylation)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035359"(negative regulation of peroxisome proliferator activated receptor signaling pathway)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042476"(odontogenesis)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048511"(rhythmic process)|go:"GO:0048642"(negative regulation of skeletal muscle tissue development)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060363"(cranial suture morphogenesis)|go:"GO:0060900"(embryonic camera-type eye formation)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0070888"(E-box binding)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:2000144"(positive regulation of DNA-templated transcription, initiation)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000276"(negative regulation of oxidative phosphorylation uncoupler activity)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:2000780"(negative regulation of double-strand break repair)|go:"GO:2000793"(cell proliferation involved in heart valve development)|go:"GO:2000802"(positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR015789(Twist)|interpro:IPR036638|rcsb pdb:2MJV|reactome:R-HSA-6785807|reactome:R-HSA-8878166|reactome:R-HSA-8939902	-	-	-	figure legend:Fig. 5a|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2020/09/08	2020/09/08	rogid:5ofdcOZrL/NXfVfFMVO8GMyh+ZY9606	rogid:1+WEEh0ruAAKCxlJQCVzBqTrhIM9606	rigid:gZ8sJlsm/MnGOTxAtHPCsbYNdv4	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P15884	uniprotkb:Q15672	intact:EBI-533224|uniprotkb:Q08AP3|uniprotkb:Q08AP2|uniprotkb:Q15440|uniprotkb:Q15441|uniprotkb:Q15439|uniprotkb:B4DT37|ensembl:ENSP00000348374|ensembl:ENSP00000457649|uniprotkb:G0LNT9|uniprotkb:G0LNU0|uniprotkb:G0LNU1|uniprotkb:G0LNU2|uniprotkb:G0LNU8|uniprotkb:G0LNU9|uniprotkb:G0LNV0|uniprotkb:G0LNV1|uniprotkb:B3KT62|uniprotkb:B3KUC0|uniprotkb:B4DUG3|uniprotkb:B7Z5M6|uniprotkb:G0LNU5|uniprotkb:H3BPQ1|uniprotkb:B7Z6Y1|uniprotkb:G0LNU4|uniprotkb:G0LNV2	intact:EBI-1797287|uniprotkb:Q92487|uniprotkb:Q99804|uniprotkb:A4D128|ensembl:ENSP00000242261	psi-mi:itf2_human(display_long)|uniprotkb:Immunoglobulin transcription factor 2(gene name synonym)|uniprotkb:SL3-3 enhancer factor 2(gene name synonym)|uniprotkb:ITF2(gene name synonym)|uniprotkb:SEF2(gene name synonym)|uniprotkb:TCF4(gene name)|psi-mi:TCF4(display_short)|uniprotkb:BHLHB19(gene name synonym)|uniprotkb:Class B basic helix-loop-helix protein 19(gene name synonym)	psi-mi:twst1_human(display_long)|uniprotkb:H-twist(gene name synonym)|uniprotkb:TWIST1(gene name)|psi-mi:TWIST1(display_short)|uniprotkb:TWIST(gene name synonym)|uniprotkb:BHLHA38(gene name synonym)|uniprotkb:Class A basic helix-loop-helix protein 38(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Singh et al. (2009)	imex:IM-28326|pubmed:19534813	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25824891|imex:IM-28326-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001230155.2|refseq:NP_001077431.1|refseq:NP_001230163.1|refseq:NP_003190.1|refseq:XP_005266796.2|ensembl:ENSG00000196628(gene)|ensembl:ENST00000356073(transcript)|ensembl:ENST00000564999(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001093"(TFIIB-class transcription factor binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0065004"(protein-DNA complex assembly)|go:"GO:0070369"(beta-catenin-TCF7L2 complex)|go:"GO:0070888"(E-box binding)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990907"(beta-catenin-TCF complex)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|mint:P15884|rcsb pdb:2KWF|rcsb pdb:6OD3|rcsb pdb:6OD4|rcsb pdb:6OD5|reactome:R-HSA-525793|refseq:NP_001335140.1|refseq:NP_001335141.1|refseq:NP_001335142.1|refseq:NP_001335143.1|refseq:NP_001335144.1|refseq:NP_001335145.1|refseq:NP_001335146.1|refseq:NP_001335147.1|refseq:NP_001335148.1|refseq:NP_001335149.1|refseq:NP_001293136.1|refseq:NP_001293137.1|refseq:NP_001230164.1|refseq:NP_001230165.1|refseq:NP_001230160.1|refseq:NP_001230161.1|refseq:NP_001230162.1|refseq:XP_006722599.1|refseq:XP_006722600.1|refseq:NP_001230156.1|refseq:NP_001230157.1|refseq:NP_001230159.1|refseq:XP_016881425.1|refseq:XP_016881429.1|refseq:XP_016881430.1|refseq:XP_016881435.1|refseq:XP_016881445.1|dip:DIP-163N	refseq:NP_000465.1|refseq:XP_011513798.1|dip:DIP-45974N|ensembl:ENSG00000122691(gene)|ensembl:ENST00000242261(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001503"(ossification)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001764"(neuron migration)|go:"GO:0001843"(neural tube closure)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003253"(cardiac neural crest cell migration involved in outflow tract morphogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007517"(muscle organ development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030500"(regulation of bone mineralization)|go:"GO:0032000"(positive regulation of fatty acid beta-oxidation)|go:"GO:0032502"(developmental process)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033128"(negative regulation of histone phosphorylation)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035359"(negative regulation of peroxisome proliferator activated receptor signaling pathway)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042476"(odontogenesis)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048511"(rhythmic process)|go:"GO:0048642"(negative regulation of skeletal muscle tissue development)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060363"(cranial suture morphogenesis)|go:"GO:0060900"(embryonic camera-type eye formation)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0070888"(E-box binding)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:2000144"(positive regulation of DNA-templated transcription, initiation)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000276"(negative regulation of oxidative phosphorylation uncoupler activity)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:2000780"(negative regulation of double-strand break repair)|go:"GO:2000793"(cell proliferation involved in heart valve development)|go:"GO:2000802"(positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR015789(Twist)|interpro:IPR036638|rcsb pdb:2MJV|reactome:R-HSA-6785807|reactome:R-HSA-8878166|reactome:R-HSA-8939902	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig. 5b|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2020/09/08	2020/09/08	rogid:5ofdcOZrL/NXfVfFMVO8GMyh+ZY9606	rogid:1+WEEh0ruAAKCxlJQCVzBqTrhIM9606	rigid:gZ8sJlsm/MnGOTxAtHPCsbYNdv4	false	myc tag:c-c	enhanced green fluorescent protein tag:c-c|mutation with no effect:38-38|mutation with no effect:73-73|mutation with no effect:77-77	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:P15884	uniprotkb:Q15672	intact:EBI-533224|uniprotkb:Q08AP3|uniprotkb:Q08AP2|uniprotkb:Q15440|uniprotkb:Q15441|uniprotkb:Q15439|uniprotkb:B4DT37|ensembl:ENSP00000348374|ensembl:ENSP00000457649|uniprotkb:G0LNT9|uniprotkb:G0LNU0|uniprotkb:G0LNU1|uniprotkb:G0LNU2|uniprotkb:G0LNU8|uniprotkb:G0LNU9|uniprotkb:G0LNV0|uniprotkb:G0LNV1|uniprotkb:B3KT62|uniprotkb:B3KUC0|uniprotkb:B4DUG3|uniprotkb:B7Z5M6|uniprotkb:G0LNU5|uniprotkb:H3BPQ1|uniprotkb:B7Z6Y1|uniprotkb:G0LNU4|uniprotkb:G0LNV2	intact:EBI-1797287|uniprotkb:Q92487|uniprotkb:Q99804|uniprotkb:A4D128|ensembl:ENSP00000242261	psi-mi:itf2_human(display_long)|uniprotkb:Immunoglobulin transcription factor 2(gene name synonym)|uniprotkb:SL3-3 enhancer factor 2(gene name synonym)|uniprotkb:ITF2(gene name synonym)|uniprotkb:SEF2(gene name synonym)|uniprotkb:TCF4(gene name)|psi-mi:TCF4(display_short)|uniprotkb:BHLHB19(gene name synonym)|uniprotkb:Class B basic helix-loop-helix protein 19(gene name synonym)	psi-mi:twst1_human(display_long)|uniprotkb:H-twist(gene name synonym)|uniprotkb:TWIST1(gene name)|psi-mi:TWIST1(display_short)|uniprotkb:TWIST(gene name synonym)|uniprotkb:BHLHA38(gene name synonym)|uniprotkb:Class A basic helix-loop-helix protein 38(gene name synonym)	psi-mi:"MI:0096"(pull down)	Singh et al. (2009)	imex:IM-28326|pubmed:19534813	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25825065|imex:IM-28326-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001230155.2|refseq:NP_001077431.1|refseq:NP_001230163.1|refseq:NP_003190.1|refseq:XP_005266796.2|ensembl:ENSG00000196628(gene)|ensembl:ENST00000356073(transcript)|ensembl:ENST00000564999(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001093"(TFIIB-class transcription factor binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0065004"(protein-DNA complex assembly)|go:"GO:0070369"(beta-catenin-TCF7L2 complex)|go:"GO:0070888"(E-box binding)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990907"(beta-catenin-TCF complex)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|mint:P15884|rcsb pdb:2KWF|rcsb pdb:6OD3|rcsb pdb:6OD4|rcsb pdb:6OD5|reactome:R-HSA-525793|refseq:NP_001335140.1|refseq:NP_001335141.1|refseq:NP_001335142.1|refseq:NP_001335143.1|refseq:NP_001335144.1|refseq:NP_001335145.1|refseq:NP_001335146.1|refseq:NP_001335147.1|refseq:NP_001335148.1|refseq:NP_001335149.1|refseq:NP_001293136.1|refseq:NP_001293137.1|refseq:NP_001230164.1|refseq:NP_001230165.1|refseq:NP_001230160.1|refseq:NP_001230161.1|refseq:NP_001230162.1|refseq:XP_006722599.1|refseq:XP_006722600.1|refseq:NP_001230156.1|refseq:NP_001230157.1|refseq:NP_001230159.1|refseq:XP_016881425.1|refseq:XP_016881429.1|refseq:XP_016881430.1|refseq:XP_016881435.1|refseq:XP_016881445.1|dip:DIP-163N	refseq:NP_000465.1|refseq:XP_011513798.1|dip:DIP-45974N|ensembl:ENSG00000122691(gene)|ensembl:ENST00000242261(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001503"(ossification)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001764"(neuron migration)|go:"GO:0001843"(neural tube closure)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003253"(cardiac neural crest cell migration involved in outflow tract morphogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007517"(muscle organ development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030500"(regulation of bone mineralization)|go:"GO:0032000"(positive regulation of fatty acid beta-oxidation)|go:"GO:0032502"(developmental process)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033128"(negative regulation of histone phosphorylation)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035359"(negative regulation of peroxisome proliferator activated receptor signaling pathway)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042476"(odontogenesis)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048511"(rhythmic process)|go:"GO:0048642"(negative regulation of skeletal muscle tissue development)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060363"(cranial suture morphogenesis)|go:"GO:0060900"(embryonic camera-type eye formation)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0070888"(E-box binding)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:2000144"(positive regulation of DNA-templated transcription, initiation)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000276"(negative regulation of oxidative phosphorylation uncoupler activity)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:2000780"(negative regulation of double-strand break repair)|go:"GO:2000793"(cell proliferation involved in heart valve development)|go:"GO:2000802"(positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR015789(Twist)|interpro:IPR036638|rcsb pdb:2MJV|reactome:R-HSA-6785807|reactome:R-HSA-8878166|reactome:R-HSA-8939902	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig. 6b|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2020/09/08	2020/12/07	rogid:5ofdcOZrL/NXfVfFMVO8GMyh+ZY9606	rogid:1+WEEh0ruAAKCxlJQCVzBqTrhIM9606	rigid:gZ8sJlsm/MnGOTxAtHPCsbYNdv4	false	tag:?-?	v5 tag:?-?|his tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)