#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P0C6X7-PRO_0000037311 uniprotkb:P0C6X7-PRO_0000037311 intact:EBI-25474079 intact:EBI-25474079 psi-mi:p0c6x7-pro_0000037311(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:p0c6x7-pro_0000037311(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:"MI:0114"(x-ray crystallography) Tan et al. (2009) pubmed:19436709|imex:IM-28162 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-25748221|imex:IM-28162-1|pdbe:2W2G - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7843867(chain-parent) intact:EBI-7843867(chain-parent) pdbe:2WCT(see-also) chain-seq-start:819|chain-seq-end:2740 chain-seq-start:819|chain-seq-end:2740 figure legend:Table 1|3d-r-factors:"Rwork: 0.211 Rfree: 0.268"|3d-resolution:2.22Å|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/07/06 2020/07/06 rogid:NKZ5d0D2HjefhmJQwgHz+M1lSt8694009 rogid:NKZ5d0D2HjefhmJQwgHz+M1lSt8694009 rigid:5ge2qJ8rBibCSuLlCqp5tbmLpbY false sufficient binding region:389-652|his tag:n-n sufficient binding region:389-652|his tag:n-n 2 0 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P0C6X7-PRO_0000037311 ensembl:ENSG00000171791 intact:EBI-25474079 intact:EBI-8772209 psi-mi:p0c6x7-pro_0000037311(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) uniprotkb:BCL2(gene name)|psi-mi:BCL2(display_short)|ensembl:bcl2_human_gene(shortlabel)|psi-mi:ENSG00000171791(display_long) psi-mi:"MI:0807"(comigration in gel electrophoresis) Tan et al. (2009) pubmed:19436709|imex:IM-28162 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-25749683|imex:IM-28162-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0250"(gene) intact:EBI-7843867(chain-parent) - - chain-seq-start:819|chain-seq-end:2740 - figure legend:Fig. 4b, Fig 5|agonist:"KCl (CHEBI:32588)"|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/07/06 2020/07/07 rogid:NKZ5d0D2HjefhmJQwgHz+M1lSt8694009 - - false mutation decreasing interaction strength:505-506|sufficient binding region:389-652|his tag:n-n|mutation decreasing interaction strength:476-477|mutation disrupting interaction strength:563-563,565-565,568-568|mutation disrupting interaction strength:565-565,568-568,571-571 sufficient binding region:?-? - - psi-mi:"MI:0816"(molecular weight estimation by staining) psi-mi:"MI:0816"(molecular weight estimation by staining) uniprotkb:P0C6X7-PRO_0000037311 intact:EBI-25749803 intact:EBI-25474079 - psi-mi:p0c6x7-pro_0000037311(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:bcl2_promoter_reverse_complement(display_short)|psi-mi:EBI-25749803(display_long) psi-mi:"MI:0807"(comigration in gel electrophoresis) Tan et al. (2009) pubmed:19436709|imex:IM-28162 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-25749823|imex:IM-28162-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0320"(ribonucleic acid) intact:EBI-7843867(chain-parent) refseq:NG_009361(see-also) - chain-seq-start:819|chain-seq-end:2740 - figure legend:Fig. 4c|comment:SUB core domain bound with reverse-complementary sequence with low affinity and independent of K+ ions|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/07/06 2020/07/07 rogid:NKZ5d0D2HjefhmJQwgHz+M1lSt8694009 - - false his tag:n-n|sufficient binding region:389-652 - - - psi-mi:"MI:0816"(molecular weight estimation by staining) psi-mi:"MI:0816"(molecular weight estimation by staining) intact:EBI-25777436 uniprotkb:P0C6X7-PRO_0000037311 ensembl:ENSGALG00000032220 intact:EBI-25474079 psi-mi:elastin_3'utr_chicken(display_short)|psi-mi:EBI-25777436(display_long) psi-mi:p0c6x7-pro_0000037311(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:"MI:0807"(comigration in gel electrophoresis) Tan et al. (2009) pubmed:19436709|imex:IM-28162 taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)") taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-25749835|imex:IM-28162-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0320"(ribonucleic acid) psi-mi:"MI:0326"(protein) - intact:EBI-7843867(chain-parent) - genomic coord:"chr19(+): 962388-962407" chain-seq-start:819|chain-seq-end:2740 figure legend:Fig. 4c|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/07/06 2020/08/14 - rogid:NKZ5d0D2HjefhmJQwgHz+M1lSt8694009 - false - his tag:n-n|sufficient binding region:389-652 - - psi-mi:"MI:0816"(molecular weight estimation by staining) psi-mi:"MI:0816"(molecular weight estimation by staining)