#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O75636-PRO_0000009142	uniprotkb:O75636-PRO_0000009142	intact:EBI-27105453	intact:EBI-27105453	psi-mi:o75636-pro_0000009142(display_long)|uniprotkb:FCN3(gene name)|psi-mi:FCN3(display_short)|uniprotkb:FCNH(gene name synonym)|uniprotkb:HAKA1(gene name synonym)|uniprotkb:Collagen/fibrinogen domain-containing lectin 3 p35(gene name synonym)|uniprotkb:Collagen/fibrinogen domain-containing protein 3(gene name synonym)|uniprotkb:Hakata antigen(gene name synonym)	psi-mi:o75636-pro_0000009142(display_long)|uniprotkb:FCN3(gene name)|psi-mi:FCN3(display_short)|uniprotkb:FCNH(gene name synonym)|uniprotkb:HAKA1(gene name synonym)|uniprotkb:Collagen/fibrinogen domain-containing lectin 3 p35(gene name synonym)|uniprotkb:Collagen/fibrinogen domain-containing protein 3(gene name synonym)|uniprotkb:Hakata antigen(gene name synonym)	psi-mi:"MI:0404"(comigration in non denaturing gel electrophoresis)	Lacroix et al. (2009)	imex:IM-29290|pubmed:19109177	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27105451|imex:IM-29290-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-11786958(chain-parent)	intact:EBI-11786958(chain-parent)	go:"GO:0051260"(protein homooligomerization)	chain-seq-start:24|chain-seq-end:299	chain-seq-start:24|chain-seq-end:299	figure legend:1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10029(crigr-cho_k1)|taxid:10029(Cricetulus griseus ovary K1)	-	2020/12/17	2021/10/14	rogid:U7HhImqa/vZsyMNLu2RRwHVIvw89606	rogid:U7HhImqa/vZsyMNLu2RRwHVIvw89606	rigid:rnSFZT89D3BgsXegZh3W+fjn8b0	false	mutation with no effect:47-47|mutation with no effect:47-47|mutation with no effect:47-47	mutation with no effect:47-47|mutation with no effect:47-47|mutation with no effect:47-47	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q15485-PRO_0000009139	uniprotkb:Q15485-PRO_0000009139	intact:EBI-26568205	intact:EBI-26568205	psi-mi:q15485-pro_0000009139(display_long)|uniprotkb:37 kDa elastin-binding protein(gene name synonym)|uniprotkb:Collagen/fibrinogen domain-containing protein 2(gene name synonym)|uniprotkb:EBP-37(gene name synonym)|uniprotkb:Ficolin-B(gene name synonym)|uniprotkb:Ficolin-beta(gene name synonym)|uniprotkb:Hucolin(gene name synonym)|uniprotkb:L-ficolin(gene name synonym)|uniprotkb:Serum lectin p35(gene name synonym)|uniprotkb:FCN2(gene name)|psi-mi:FCN2(display_short)|uniprotkb:FCNL(gene name synonym)	psi-mi:q15485-pro_0000009139(display_long)|uniprotkb:37 kDa elastin-binding protein(gene name synonym)|uniprotkb:Collagen/fibrinogen domain-containing protein 2(gene name synonym)|uniprotkb:EBP-37(gene name synonym)|uniprotkb:Ficolin-B(gene name synonym)|uniprotkb:Ficolin-beta(gene name synonym)|uniprotkb:Hucolin(gene name synonym)|uniprotkb:L-ficolin(gene name synonym)|uniprotkb:Serum lectin p35(gene name synonym)|uniprotkb:FCN2(gene name)|psi-mi:FCN2(display_short)|uniprotkb:FCNL(gene name synonym)	psi-mi:"MI:0404"(comigration in non denaturing gel electrophoresis)	Lacroix et al. (2009)	imex:IM-29290|pubmed:19109177	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27105474|imex:IM-29290-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-7468784(chain-parent)	intact:EBI-7468784(chain-parent)	go:"GO:0051260"(protein homooligomerization)	chain-seq-start:26|chain-seq-end:313	chain-seq-start:26|chain-seq-end:313	figure legend:2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10029(crigr-cho_k1)|taxid:10029(Cricetulus griseus ovary K1)	-	2020/12/17	2021/10/14	rogid:3+TC0S8B7lEniYAYFj/v9sLis3Y9606	rogid:3+TC0S8B7lEniYAYFj/v9sLis3Y9606	rigid:3SvaTcRrNoy5zxiiXRwk222yed8	false	mutation with no effect:57-57|mutation with no effect:57-57|mutation with no effect:57-57	mutation with no effect:57-57|mutation with no effect:57-57|mutation with no effect:57-57	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q15485-PRO_0000009139	uniprotkb:Q15485-PRO_0000009139	intact:EBI-26568205	intact:EBI-26568205	psi-mi:q15485-pro_0000009139(display_long)|uniprotkb:37 kDa elastin-binding protein(gene name synonym)|uniprotkb:Collagen/fibrinogen domain-containing protein 2(gene name synonym)|uniprotkb:EBP-37(gene name synonym)|uniprotkb:Ficolin-B(gene name synonym)|uniprotkb:Ficolin-beta(gene name synonym)|uniprotkb:Hucolin(gene name synonym)|uniprotkb:L-ficolin(gene name synonym)|uniprotkb:Serum lectin p35(gene name synonym)|uniprotkb:FCN2(gene name)|psi-mi:FCN2(display_short)|uniprotkb:FCNL(gene name synonym)	psi-mi:q15485-pro_0000009139(display_long)|uniprotkb:37 kDa elastin-binding protein(gene name synonym)|uniprotkb:Collagen/fibrinogen domain-containing protein 2(gene name synonym)|uniprotkb:EBP-37(gene name synonym)|uniprotkb:Ficolin-B(gene name synonym)|uniprotkb:Ficolin-beta(gene name synonym)|uniprotkb:Hucolin(gene name synonym)|uniprotkb:L-ficolin(gene name synonym)|uniprotkb:Serum lectin p35(gene name synonym)|uniprotkb:FCN2(gene name)|psi-mi:FCN2(display_short)|uniprotkb:FCNL(gene name synonym)	psi-mi:"MI:0040"(electron microscopy)	Lacroix et al. (2009)	imex:IM-29290|pubmed:19109177	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27105506|imex:IM-29290-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-7468784(chain-parent)	intact:EBI-7468784(chain-parent)	-	chain-seq-start:26|chain-seq-end:313	chain-seq-start:26|chain-seq-end:313	figure legend:3|comment:The views show either a parachute-like structure with, in most cases, four heads connected by a rod-like structure to a small globe at the opposite end, or six heads surrounding a central globe.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10029(crigr-cho_k1)|taxid:10029(Cricetulus griseus ovary K1)	-	2020/12/17	2021/10/14	rogid:3+TC0S8B7lEniYAYFj/v9sLis3Y9606	rogid:3+TC0S8B7lEniYAYFj/v9sLis3Y9606	rigid:3SvaTcRrNoy5zxiiXRwk222yed8	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75636-PRO_0000009142	uniprotkb:O75636-PRO_0000009142	intact:EBI-27105453	intact:EBI-27105453	psi-mi:o75636-pro_0000009142(display_long)|uniprotkb:FCN3(gene name)|psi-mi:FCN3(display_short)|uniprotkb:FCNH(gene name synonym)|uniprotkb:HAKA1(gene name synonym)|uniprotkb:Collagen/fibrinogen domain-containing lectin 3 p35(gene name synonym)|uniprotkb:Collagen/fibrinogen domain-containing protein 3(gene name synonym)|uniprotkb:Hakata antigen(gene name synonym)	psi-mi:o75636-pro_0000009142(display_long)|uniprotkb:FCN3(gene name)|psi-mi:FCN3(display_short)|uniprotkb:FCNH(gene name synonym)|uniprotkb:HAKA1(gene name synonym)|uniprotkb:Collagen/fibrinogen domain-containing lectin 3 p35(gene name synonym)|uniprotkb:Collagen/fibrinogen domain-containing protein 3(gene name synonym)|uniprotkb:Hakata antigen(gene name synonym)	psi-mi:"MI:0040"(electron microscopy)	Lacroix et al. (2009)	imex:IM-29290|pubmed:19109177	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27105522|imex:IM-29290-23	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-11786958(chain-parent)	intact:EBI-11786958(chain-parent)	-	chain-seq-start:24|chain-seq-end:299	chain-seq-start:24|chain-seq-end:299	figure legend:3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10029(crigr-cho_k1)|taxid:10029(Cricetulus griseus ovary K1)	-	2020/12/17	2021/10/14	rogid:U7HhImqa/vZsyMNLu2RRwHVIvw89606	rogid:U7HhImqa/vZsyMNLu2RRwHVIvw89606	rigid:rnSFZT89D3BgsXegZh3W+fjn8b0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02769	uniprotkb:Q15485-PRO_0000009139	intact:EBI-2296927|uniprotkb:A5PJX3|uniprotkb:O02787|uniprotkb:P04277|uniprotkb:Q3SZR2	intact:EBI-26568205	psi-mi:albu_bovin(display_long)|uniprotkb:ALB(gene name)|psi-mi:ALB(display_short)|uniprotkb:BSA(gene name synonym)	psi-mi:q15485-pro_0000009139(display_long)|uniprotkb:37 kDa elastin-binding protein(gene name synonym)|uniprotkb:Collagen/fibrinogen domain-containing protein 2(gene name synonym)|uniprotkb:EBP-37(gene name synonym)|uniprotkb:Ficolin-B(gene name synonym)|uniprotkb:Ficolin-beta(gene name synonym)|uniprotkb:Hucolin(gene name synonym)|uniprotkb:L-ficolin(gene name synonym)|uniprotkb:Serum lectin p35(gene name synonym)|uniprotkb:FCN2(gene name)|psi-mi:FCN2(display_short)|uniprotkb:FCNL(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Lacroix et al. (2009)	imex:IM-29290|pubmed:19109177	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27105539|imex:IM-29290-25	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:4JK4|refseq:NP_851335.1|interpro:IPR000264(Serum albumin)|interpro:IPR020858|interpro:IPR020857|interpro:IPR014760(Serum albumin, N-terminal)|interpro:IPR021177|rcsb pdb:2L7U|rcsb pdb:3V03|rcsb pdb:4F5S|rcsb pdb:4OR0|rcsb pdb:6QS9|rcsb pdb:6RJV|go:"GO:0003677"(DNA binding)|go:"GO:0005504"(fatty acid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0015643"(toxic substance binding)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0051659"(maintenance of mitochondrion location)|go:"GO:1903981"(enterobactin binding)	intact:EBI-7468784(chain-parent)	-	-	chain-seq-start:26|chain-seq-end:313	figure legend:4, Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1.6x10^-9(molar)	2020/12/17	2021/10/14	rogid:J8N23Xjyoe+UM5phxwqJtC2a1+M9913	rogid:3+TC0S8B7lEniYAYFj/v9sLis3Y9606	rigid:ORmgCJ/MycSmSJEOTA3FHn9Y2xE	false	monoacetylated residue:?-?	mutation decreasing interaction strength:57-57|mutation with no effect:57-57|mutation decreasing interaction strength:57-57	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02769	uniprotkb:O75636-PRO_0000009142	intact:EBI-2296927|uniprotkb:A5PJX3|uniprotkb:O02787|uniprotkb:P04277|uniprotkb:Q3SZR2	intact:EBI-27105453	psi-mi:albu_bovin(display_long)|uniprotkb:ALB(gene name)|psi-mi:ALB(display_short)|uniprotkb:BSA(gene name synonym)	psi-mi:o75636-pro_0000009142(display_long)|uniprotkb:FCN3(gene name)|psi-mi:FCN3(display_short)|uniprotkb:FCNH(gene name synonym)|uniprotkb:HAKA1(gene name synonym)|uniprotkb:Collagen/fibrinogen domain-containing lectin 3 p35(gene name synonym)|uniprotkb:Collagen/fibrinogen domain-containing protein 3(gene name synonym)|uniprotkb:Hakata antigen(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Lacroix et al. (2009)	imex:IM-29290|pubmed:19109177	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27105555|imex:IM-29290-27	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:4JK4|refseq:NP_851335.1|interpro:IPR000264(Serum albumin)|interpro:IPR020858|interpro:IPR020857|interpro:IPR014760(Serum albumin, N-terminal)|interpro:IPR021177|rcsb pdb:2L7U|rcsb pdb:3V03|rcsb pdb:4F5S|rcsb pdb:4OR0|rcsb pdb:6QS9|rcsb pdb:6RJV|go:"GO:0003677"(DNA binding)|go:"GO:0005504"(fatty acid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0015643"(toxic substance binding)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0051659"(maintenance of mitochondrion location)|go:"GO:1903981"(enterobactin binding)	intact:EBI-11786958(chain-parent)	-	-	chain-seq-start:24|chain-seq-end:299	figure legend:4, Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:6.5x10^-9(molar)	2020/12/17	2021/10/14	rogid:J8N23Xjyoe+UM5phxwqJtC2a1+M9913	rogid:U7HhImqa/vZsyMNLu2RRwHVIvw89606	rigid:DdDBuQl7yBcpMw6C6h+WmfBtX+0	false	monoacetylated residue:?-?	mutation decreasing interaction strength:47-47|mutation decreasing interaction strength:47-47|mutation decreasing interaction strength:47-47	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O00187-1	uniprotkb:Q15485-PRO_0000009139	intact:EBI-26357096|ensembl:ENSP00000383690	intact:EBI-26568205	psi-mi:o00187-1(display_long)|uniprotkb:MBL-associated serine protease 2(gene name synonym)|uniprotkb:Mannose-binding protein-associated serine protease 2(gene name synonym)|uniprotkb:MASP2(gene name)|psi-mi:MASP2(display_short)	psi-mi:q15485-pro_0000009139(display_long)|uniprotkb:37 kDa elastin-binding protein(gene name synonym)|uniprotkb:Collagen/fibrinogen domain-containing protein 2(gene name synonym)|uniprotkb:EBP-37(gene name synonym)|uniprotkb:Ficolin-B(gene name synonym)|uniprotkb:Ficolin-beta(gene name synonym)|uniprotkb:Hucolin(gene name synonym)|uniprotkb:L-ficolin(gene name synonym)|uniprotkb:Serum lectin p35(gene name synonym)|uniprotkb:FCN2(gene name)|psi-mi:FCN2(display_short)|uniprotkb:FCNL(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Lacroix et al. (2009)	imex:IM-29290|pubmed:19109177	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27105579|imex:IM-29290-29	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000400897(transcript)|ensembl:ENSG00000009724(gene)|intact:EBI-7965040(isoform-parent)	intact:EBI-7468784(chain-parent)	-	-	chain-seq-start:26|chain-seq-end:313	figure legend:5, Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:2.3x10^-9(molar)	2020/12/17	2021/10/14	rogid:S48IDwjdZ8M6vIJD6iM0XplSN609606	rogid:3+TC0S8B7lEniYAYFj/v9sLis3Y9606	rigid:FEb5LyWbWDlKQcspkvlnbwuL+FQ	false	-	mutation disrupting interaction strength:57-57|mutation disrupting interaction strength:57-57|mutation disrupting interaction strength:57-57	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O00187-2	uniprotkb:Q15485-PRO_0000009139	intact:EBI-26356134|ensembl:ENSP00000383691	intact:EBI-26568205	psi-mi:o00187-2(display_long)|uniprotkb:MASP2(gene name)|psi-mi:MASP2(display_short)|uniprotkb:MBL-associated serine protease 2(gene name synonym)|uniprotkb:Mannose-binding protein-associated serine protease 2(gene name synonym)|uniprotkb:MAp19(isoform synonym)|uniprotkb:Small MBL-associated protein(isoform synonym)|uniprotkb:sMAP(isoform synonym)	psi-mi:q15485-pro_0000009139(display_long)|uniprotkb:37 kDa elastin-binding protein(gene name synonym)|uniprotkb:Collagen/fibrinogen domain-containing protein 2(gene name synonym)|uniprotkb:EBP-37(gene name synonym)|uniprotkb:Ficolin-B(gene name synonym)|uniprotkb:Ficolin-beta(gene name synonym)|uniprotkb:Hucolin(gene name synonym)|uniprotkb:L-ficolin(gene name synonym)|uniprotkb:Serum lectin p35(gene name synonym)|uniprotkb:FCN2(gene name)|psi-mi:FCN2(display_short)|uniprotkb:FCNL(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Lacroix et al. (2009)	imex:IM-29290|pubmed:19109177	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27105595|imex:IM-29290-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000009724(gene)|ensembl:ENST00000400898(transcript)|intact:EBI-7965040(isoform-parent)	intact:EBI-7468784(chain-parent)	-	-	chain-seq-start:26|chain-seq-end:313	figure legend:5, Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:7.2x10^-9(molar)	2020/12/17	2021/10/14	rogid:HFrZYSDiESe89IQqgChsunpvyTc9606	rogid:3+TC0S8B7lEniYAYFj/v9sLis3Y9606	rigid:fmyoKQvXSTXmI8mWzFexA7A9+oo	false	-	mutation disrupting interaction strength:57-57|mutation disrupting interaction strength:57-57|mutation disrupting interaction strength:57-57	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O00187-1	uniprotkb:O75636-PRO_0000009142	intact:EBI-26357096|ensembl:ENSP00000383690	intact:EBI-27105453	psi-mi:o00187-1(display_long)|uniprotkb:MBL-associated serine protease 2(gene name synonym)|uniprotkb:Mannose-binding protein-associated serine protease 2(gene name synonym)|uniprotkb:MASP2(gene name)|psi-mi:MASP2(display_short)	psi-mi:o75636-pro_0000009142(display_long)|uniprotkb:FCN3(gene name)|psi-mi:FCN3(display_short)|uniprotkb:FCNH(gene name synonym)|uniprotkb:HAKA1(gene name synonym)|uniprotkb:Collagen/fibrinogen domain-containing lectin 3 p35(gene name synonym)|uniprotkb:Collagen/fibrinogen domain-containing protein 3(gene name synonym)|uniprotkb:Hakata antigen(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Lacroix et al. (2009)	imex:IM-29290|pubmed:19109177	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27105609|imex:IM-29290-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000400897(transcript)|ensembl:ENSG00000009724(gene)|intact:EBI-7965040(isoform-parent)	intact:EBI-11786958(chain-parent)	-	-	chain-seq-start:24|chain-seq-end:299	figure legend:5, Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:2.3x10^-9(molar)	2020/12/17	2021/10/14	rogid:S48IDwjdZ8M6vIJD6iM0XplSN609606	rogid:U7HhImqa/vZsyMNLu2RRwHVIvw89606	rigid:AReIHnJMtcs40sBXWSW1Byq2LA4	false	-	mutation disrupting interaction strength:47-47|mutation disrupting interaction strength:47-47|mutation disrupting interaction strength:47-47	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O00187-2	uniprotkb:O75636-PRO_0000009142	intact:EBI-26356134|ensembl:ENSP00000383691	intact:EBI-27105453	psi-mi:o00187-2(display_long)|uniprotkb:MASP2(gene name)|psi-mi:MASP2(display_short)|uniprotkb:MBL-associated serine protease 2(gene name synonym)|uniprotkb:Mannose-binding protein-associated serine protease 2(gene name synonym)|uniprotkb:MAp19(isoform synonym)|uniprotkb:Small MBL-associated protein(isoform synonym)|uniprotkb:sMAP(isoform synonym)	psi-mi:o75636-pro_0000009142(display_long)|uniprotkb:FCN3(gene name)|psi-mi:FCN3(display_short)|uniprotkb:FCNH(gene name synonym)|uniprotkb:HAKA1(gene name synonym)|uniprotkb:Collagen/fibrinogen domain-containing lectin 3 p35(gene name synonym)|uniprotkb:Collagen/fibrinogen domain-containing protein 3(gene name synonym)|uniprotkb:Hakata antigen(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Lacroix et al. (2009)	imex:IM-29290|pubmed:19109177	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27105625|imex:IM-29290-31	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000009724(gene)|ensembl:ENST00000400898(transcript)|intact:EBI-7965040(isoform-parent)	intact:EBI-11786958(chain-parent)	-	-	chain-seq-start:24|chain-seq-end:299	figure legend:5, Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:13.2x10^-9(molar)	2020/12/17	2021/10/14	rogid:HFrZYSDiESe89IQqgChsunpvyTc9606	rogid:U7HhImqa/vZsyMNLu2RRwHVIvw89606	rigid:VRf9I5uQaTRvZmQ9n+HL8t39FLM	false	-	mutation disrupting interaction strength:47-47|mutation disrupting interaction strength:47-47|mutation disrupting interaction strength:47-47	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P48740	uniprotkb:O75636-PRO_0000009142	intact:EBI-6380536|ensembl:ENSP00000336792|uniprotkb:A8K542|uniprotkb:A8K6M1|uniprotkb:B4E2L7|uniprotkb:O95570|uniprotkb:Q68D21|uniprotkb:Q8IUV8|uniprotkb:Q96RS4|uniprotkb:Q9UF09	intact:EBI-27105453	psi-mi:masp1_human(display_long)|uniprotkb:MASP1(gene name)|psi-mi:MASP1(display_short)|uniprotkb:CRARF(gene name synonym)|uniprotkb:CRARF1(gene name synonym)|uniprotkb:PRSS5(gene name synonym)|uniprotkb:Complement factor MASP-3(gene name synonym)|uniprotkb:Complement-activating component of Ra-reactive factor(gene name synonym)|uniprotkb:Mannose-binding lectin-associated serine protease 1(gene name synonym)|uniprotkb:Mannose-binding protein-associated serine protease(gene name synonym)|uniprotkb:Ra-reactive factor serine protease p100(gene name synonym)|uniprotkb:Serine protease 5(gene name synonym)	psi-mi:o75636-pro_0000009142(display_long)|uniprotkb:FCN3(gene name)|psi-mi:FCN3(display_short)|uniprotkb:FCNH(gene name synonym)|uniprotkb:HAKA1(gene name synonym)|uniprotkb:Collagen/fibrinogen domain-containing lectin 3 p35(gene name synonym)|uniprotkb:Collagen/fibrinogen domain-containing protein 3(gene name synonym)|uniprotkb:Hakata antigen(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Lacroix et al. (2009)	imex:IM-29290|pubmed:19109177	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27105642|imex:IM-29290-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016862361.1|ensembl:ENSG00000127241(gene)|ensembl:ENST00000337774(transcript)|go:"GO:0001867"(complement activation, lectin pathway)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008233"(peptidase activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045916"(negative regulation of complement activation)|go:"GO:0048306"(calcium-dependent protein binding)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000859(CUB)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR018097|interpro:IPR018114|interpro:IPR033116|interpro:IPR035914|interpro:IPR035976|interpro:IPR043504|rcsb pdb:3DEM|rcsb pdb:3GOV|rcsb pdb:4AQB|rcsb pdb:4DJZ|rcsb pdb:4IGD|rcsb pdb:4IW4|rcsb pdb:4KKD|reactome:R-HSA-166662|reactome:R-HSA-166663|reactome:R-HSA-2855086|reactome:R-HSA-3000480|dip:DIP-61382N|refseq:NP_001027019.1|refseq:NP_001870.3|refseq:NP_624302.1	intact:EBI-11786958(chain-parent)	-	-	chain-seq-start:24|chain-seq-end:299	figure legend:Table 3|comment:Table 3 gives results for full length MASP1, but no results are present in Figure 6 for this molecule.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:2.9x10^-9(molar)	2020/12/17	2021/10/14	rogid:Yqzsp6f/Mg3AyvyK42mX/kQ3s389606	rogid:U7HhImqa/vZsyMNLu2RRwHVIvw89606	rigid:3wsevuqg1e2TG2/QxQoZpqZxOiA	false	-	mutation decreasing interaction strength:47-47	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P48740-2	uniprotkb:O75636-PRO_0000009142	intact:EBI-26435098|ensembl:ENSP00000296280	intact:EBI-27105453	psi-mi:p48740-2(display_long)|uniprotkb:Mannose-binding protein-associated serine protease(gene name synonym)|uniprotkb:Ra-reactive factor serine protease p100(gene name synonym)|uniprotkb:Serine protease 5(gene name synonym)|uniprotkb:MASP-3(isoform synonym)|uniprotkb:MASP1(gene name)|psi-mi:MASP1(display_short)|uniprotkb:CRARF(gene name synonym)|uniprotkb:CRARF1(gene name synonym)|uniprotkb:PRSS5(gene name synonym)|uniprotkb:Complement factor MASP-3(gene name synonym)|uniprotkb:Complement-activating component of Ra-reactive factor(gene name synonym)|uniprotkb:Mannose-binding lectin-associated serine protease 1(gene name synonym)	psi-mi:o75636-pro_0000009142(display_long)|uniprotkb:FCN3(gene name)|psi-mi:FCN3(display_short)|uniprotkb:FCNH(gene name synonym)|uniprotkb:HAKA1(gene name synonym)|uniprotkb:Collagen/fibrinogen domain-containing lectin 3 p35(gene name synonym)|uniprotkb:Collagen/fibrinogen domain-containing protein 3(gene name synonym)|uniprotkb:Hakata antigen(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Lacroix et al. (2009)	imex:IM-29290|pubmed:19109177	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27105656|imex:IM-29290-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000127241(gene)|ensembl:ENST00000296280(transcript)|intact:EBI-6380536(isoform-parent)	intact:EBI-11786958(chain-parent)	-	-	chain-seq-start:24|chain-seq-end:299	figure legend:6 B/D, Table 3|comment:"Figure 6D:the WT CUB-EGF construct did bind to H-Ficolin but the data could not be analysed  as there was no fit using the Langmuir 1:1 model. The CUB-EGF construct mutants K47A and K47R did not bind."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:2.2x10^-9(molar)	2020/12/17	2021/10/14	rogid:tXsz/6dPTPLuD03oT3LxFm6yDA09606	rogid:U7HhImqa/vZsyMNLu2RRwHVIvw89606	rigid:P4mhX96PNWXY2SMu5oSo9lz/mrU	false	sufficient binding region:1-184	mutation disrupting interaction strength:47-47|mutation disrupting interaction strength:47-47|mutation decreasing interaction strength:47-47	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P48740	uniprotkb:Q15485-PRO_0000009139	intact:EBI-6380536|ensembl:ENSP00000336792|uniprotkb:A8K542|uniprotkb:A8K6M1|uniprotkb:B4E2L7|uniprotkb:O95570|uniprotkb:Q68D21|uniprotkb:Q8IUV8|uniprotkb:Q96RS4|uniprotkb:Q9UF09	intact:EBI-26568205	psi-mi:masp1_human(display_long)|uniprotkb:MASP1(gene name)|psi-mi:MASP1(display_short)|uniprotkb:CRARF(gene name synonym)|uniprotkb:CRARF1(gene name synonym)|uniprotkb:PRSS5(gene name synonym)|uniprotkb:Complement factor MASP-3(gene name synonym)|uniprotkb:Complement-activating component of Ra-reactive factor(gene name synonym)|uniprotkb:Mannose-binding lectin-associated serine protease 1(gene name synonym)|uniprotkb:Mannose-binding protein-associated serine protease(gene name synonym)|uniprotkb:Ra-reactive factor serine protease p100(gene name synonym)|uniprotkb:Serine protease 5(gene name synonym)	psi-mi:q15485-pro_0000009139(display_long)|uniprotkb:37 kDa elastin-binding protein(gene name synonym)|uniprotkb:Collagen/fibrinogen domain-containing protein 2(gene name synonym)|uniprotkb:EBP-37(gene name synonym)|uniprotkb:Ficolin-B(gene name synonym)|uniprotkb:Ficolin-beta(gene name synonym)|uniprotkb:Hucolin(gene name synonym)|uniprotkb:L-ficolin(gene name synonym)|uniprotkb:Serum lectin p35(gene name synonym)|uniprotkb:FCN2(gene name)|psi-mi:FCN2(display_short)|uniprotkb:FCNL(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Lacroix et al. (2009)	imex:IM-29290|pubmed:19109177	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27105674|imex:IM-29290-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016862361.1|ensembl:ENSG00000127241(gene)|ensembl:ENST00000337774(transcript)|go:"GO:0001867"(complement activation, lectin pathway)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008233"(peptidase activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045916"(negative regulation of complement activation)|go:"GO:0048306"(calcium-dependent protein binding)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000859(CUB)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR018097|interpro:IPR018114|interpro:IPR033116|interpro:IPR035914|interpro:IPR035976|interpro:IPR043504|rcsb pdb:3DEM|rcsb pdb:3GOV|rcsb pdb:4AQB|rcsb pdb:4DJZ|rcsb pdb:4IGD|rcsb pdb:4IW4|rcsb pdb:4KKD|reactome:R-HSA-166662|reactome:R-HSA-166663|reactome:R-HSA-2855086|reactome:R-HSA-3000480|dip:DIP-61382N|refseq:NP_001027019.1|refseq:NP_001870.3|refseq:NP_624302.1	intact:EBI-7468784(chain-parent)	-	-	chain-seq-start:26|chain-seq-end:313	figure legend:Table 3, Figure 6 A/C|comment:Table 3 gives results for full length MASP1, but no results are present in Figure 6 for this molecule.|comment:The Kd for the  K57R mutant in the CUB1-EGF-CUB2  construct  was 65.2 E-9. No binding was detected for the K57R mutant in the  CUB1-EGF construct. No binding was detected for K57A or K57E mutants, when used.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:5.6x10^-9(molar)	2020/12/17	2021/10/14	rogid:Yqzsp6f/Mg3AyvyK42mX/kQ3s389606	rogid:3+TC0S8B7lEniYAYFj/v9sLis3Y9606	rigid:JVpgi2GmZz2KKjDRBWqzRxKTCwA	false	sufficient binding region:1-297|sufficient binding region:1-184	mutation decreasing interaction strength:57-57	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P48740-2	uniprotkb:Q15485-PRO_0000009139	intact:EBI-26435098|ensembl:ENSP00000296280	intact:EBI-26568205	psi-mi:p48740-2(display_long)|uniprotkb:Mannose-binding protein-associated serine protease(gene name synonym)|uniprotkb:Ra-reactive factor serine protease p100(gene name synonym)|uniprotkb:Serine protease 5(gene name synonym)|uniprotkb:MASP-3(isoform synonym)|uniprotkb:MASP1(gene name)|psi-mi:MASP1(display_short)|uniprotkb:CRARF(gene name synonym)|uniprotkb:CRARF1(gene name synonym)|uniprotkb:PRSS5(gene name synonym)|uniprotkb:Complement factor MASP-3(gene name synonym)|uniprotkb:Complement-activating component of Ra-reactive factor(gene name synonym)|uniprotkb:Mannose-binding lectin-associated serine protease 1(gene name synonym)	psi-mi:q15485-pro_0000009139(display_long)|uniprotkb:37 kDa elastin-binding protein(gene name synonym)|uniprotkb:Collagen/fibrinogen domain-containing protein 2(gene name synonym)|uniprotkb:EBP-37(gene name synonym)|uniprotkb:Ficolin-B(gene name synonym)|uniprotkb:Ficolin-beta(gene name synonym)|uniprotkb:Hucolin(gene name synonym)|uniprotkb:L-ficolin(gene name synonym)|uniprotkb:Serum lectin p35(gene name synonym)|uniprotkb:FCN2(gene name)|psi-mi:FCN2(display_short)|uniprotkb:FCNL(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Lacroix et al. (2009)	imex:IM-29290|pubmed:19109177	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27105683|imex:IM-29290-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000127241(gene)|ensembl:ENST00000296280(transcript)|intact:EBI-6380536(isoform-parent)	intact:EBI-7468784(chain-parent)	-	-	chain-seq-start:26|chain-seq-end:313	figure legend:Table 3|comment:Table 3 gives results for full length MASP3, but no results are present in Figure 6 for this molecule.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:10.1x10^-9(molar)	2020/12/17	2021/10/14	rogid:tXsz/6dPTPLuD03oT3LxFm6yDA09606	rogid:3+TC0S8B7lEniYAYFj/v9sLis3Y9606	rigid:RixSC3nfoNByL08fuTEqLJ+7Puo	false	-	mutation decreasing interaction strength:57-57	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P27797	uniprotkb:Q15485-PRO_0000009139	intact:EBI-1049597|uniprotkb:Q6IAT4|uniprotkb:Q9UDG2|ensembl:ENSP00000320866|ensembl:ENSP00000466037	intact:EBI-26568205	psi-mi:calr_human(display_long)|uniprotkb:CRP55(gene name synonym)|uniprotkb:Calregulin(gene name synonym)|uniprotkb:HACBP(gene name synonym)|uniprotkb:Endoplasmic reticulum resident protein 60(gene name synonym)|uniprotkb:grp60(gene name synonym)|uniprotkb:CALR(gene name)|psi-mi:CALR(display_short)|uniprotkb:CRTC(gene name synonym)	psi-mi:q15485-pro_0000009139(display_long)|uniprotkb:37 kDa elastin-binding protein(gene name synonym)|uniprotkb:Collagen/fibrinogen domain-containing protein 2(gene name synonym)|uniprotkb:EBP-37(gene name synonym)|uniprotkb:Ficolin-B(gene name synonym)|uniprotkb:Ficolin-beta(gene name synonym)|uniprotkb:Hucolin(gene name synonym)|uniprotkb:L-ficolin(gene name synonym)|uniprotkb:Serum lectin p35(gene name synonym)|uniprotkb:FCN2(gene name)|psi-mi:FCN2(display_short)|uniprotkb:FCNL(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Lacroix et al. (2009)	imex:IM-29290|pubmed:19109177	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27105707|imex:IM-29290-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004334.1|ensembl:ENSG00000179218(gene)|ensembl:ENST00000316448(transcript)|ensembl:ENST00000586967(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0002502"(peptide antigen assembly with MHC class I protein complex)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005506"(iron ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006457"(protein folding)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0033018"(sarcoplasmic reticulum lumen)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0033144"(negative regulation of intracellular steroid hormone receptor signaling pathway)|go:"GO:0033574"(response to testosterone)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0040020"(regulation of meiotic nuclear division)|go:"GO:0042277"(peptide binding)|go:"GO:0042493"|go:"GO:0042562"(hormone binding)|go:"GO:0042824"(MHC class I peptide loading complex)|go:"GO:0042921"(glucocorticoid receptor signaling pathway)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051208"(sequestering of calcium ion)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060473"(cortical granule)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0090398"(cellular senescence)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901164"(negative regulation of trophoblast cell migration)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000510"(positive regulation of dendritic cell chemotaxis)|interpro:IPR001580(Calreticulin/calnexin)|interpro:IPR009033(Calreticulin/calnexin, P)|interpro:IPR009169(Calreticulin)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR018124|mint:P27797|rcsb pdb:2CLR|rcsb pdb:3DOW|rcsb pdb:3POS|rcsb pdb:3POW|rcsb pdb:5LK5|rcsb pdb:5V90|rcsb pdb:6ENY|reactome:R-HSA-1236974|reactome:R-HSA-168316|reactome:R-HSA-3000480|reactome:R-HSA-3000484|reactome:R-HSA-381183|reactome:R-HSA-901042|reactome:R-HSA-983170|dip:DIP-104N	intact:EBI-7468784(chain-parent)	-	-	chain-seq-start:26|chain-seq-end:313	figure legend:8|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/17	2021/10/14	rogid:FSPSiiN6YTaETDyAWwAP3wV6zRI9606	rogid:3+TC0S8B7lEniYAYFj/v9sLis3Y9606	rigid:I5VaDCEYeRyKB06J3626bG9OxBE	false	-	mutation decreasing interaction strength:57-57|mutation with no effect:57-57|mutation decreasing interaction strength:57-57	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P27797	uniprotkb:O75636-PRO_0000009142	intact:EBI-1049597|uniprotkb:Q6IAT4|uniprotkb:Q9UDG2|ensembl:ENSP00000320866|ensembl:ENSP00000466037	intact:EBI-27105453	psi-mi:calr_human(display_long)|uniprotkb:CRP55(gene name synonym)|uniprotkb:Calregulin(gene name synonym)|uniprotkb:HACBP(gene name synonym)|uniprotkb:Endoplasmic reticulum resident protein 60(gene name synonym)|uniprotkb:grp60(gene name synonym)|uniprotkb:CALR(gene name)|psi-mi:CALR(display_short)|uniprotkb:CRTC(gene name synonym)	psi-mi:o75636-pro_0000009142(display_long)|uniprotkb:FCN3(gene name)|psi-mi:FCN3(display_short)|uniprotkb:FCNH(gene name synonym)|uniprotkb:HAKA1(gene name synonym)|uniprotkb:Collagen/fibrinogen domain-containing lectin 3 p35(gene name synonym)|uniprotkb:Collagen/fibrinogen domain-containing protein 3(gene name synonym)|uniprotkb:Hakata antigen(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Lacroix et al. (2009)	imex:IM-29290|pubmed:19109177	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27105723|imex:IM-29290-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004334.1|ensembl:ENSG00000179218(gene)|ensembl:ENST00000316448(transcript)|ensembl:ENST00000586967(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0002502"(peptide antigen assembly with MHC class I protein complex)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005506"(iron ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006457"(protein folding)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0033018"(sarcoplasmic reticulum lumen)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0033144"(negative regulation of intracellular steroid hormone receptor signaling pathway)|go:"GO:0033574"(response to testosterone)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0040020"(regulation of meiotic nuclear division)|go:"GO:0042277"(peptide binding)|go:"GO:0042493"|go:"GO:0042562"(hormone binding)|go:"GO:0042824"(MHC class I peptide loading complex)|go:"GO:0042921"(glucocorticoid receptor signaling pathway)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051208"(sequestering of calcium ion)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060473"(cortical granule)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0090398"(cellular senescence)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901164"(negative regulation of trophoblast cell migration)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000510"(positive regulation of dendritic cell chemotaxis)|interpro:IPR001580(Calreticulin/calnexin)|interpro:IPR009033(Calreticulin/calnexin, P)|interpro:IPR009169(Calreticulin)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR018124|mint:P27797|rcsb pdb:2CLR|rcsb pdb:3DOW|rcsb pdb:3POS|rcsb pdb:3POW|rcsb pdb:5LK5|rcsb pdb:5V90|rcsb pdb:6ENY|reactome:R-HSA-1236974|reactome:R-HSA-168316|reactome:R-HSA-3000480|reactome:R-HSA-3000484|reactome:R-HSA-381183|reactome:R-HSA-901042|reactome:R-HSA-983170|dip:DIP-104N	intact:EBI-11786958(chain-parent)	-	-	chain-seq-start:24|chain-seq-end:299	figure legend:8|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/17	2021/10/14	rogid:FSPSiiN6YTaETDyAWwAP3wV6zRI9606	rogid:U7HhImqa/vZsyMNLu2RRwHVIvw89606	rigid:yG0eYgGQLv9T7U3nJkEPyJVNhUY	false	-	mutation decreasing interaction strength:47-47|mutation decreasing interaction strength:47-47|mutation with no effect:47-47	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)