#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P0C6X1-PRO_0000037301 uniprotkb:P0C6X1-PRO_0000037301 intact:EBI-25708564 intact:EBI-25708564 psi-mi:p0c6x1-pro_0000037301(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:p0c6x1-pro_0000037301(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:"MI:0114"(x-ray crystallography) Ponnusamy et al. (2008) pubmed:18694760|imex:IM-28148 taxid:11137(hcov-229e)|taxid:11137(Human coronavirus 229E) taxid:11137(hcov-229e)|taxid:11137(Human coronavirus 229E) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-25708571|pdbe:2J97|imex:IM-28148-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-25637276(chain-parent) intact:EBI-25637276(chain-parent) pdbe:2J98(see-also) chain-seq-start:3825|chain-seq-end:3933 chain-seq-start:3825|chain-seq-end:3933 figure legend:Table 1|3d-resolution:1.75Å|3d-r-factors:Rwork - 0.191 Rfree - 0.225|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/06/30 2020/06/30 rogid:2LkAWeifVbpkA7btnag+3+PtMZ811137 rogid:2LkAWeifVbpkA7btnag+3+PtMZ811137 rigid:Z2KucvLeVr/N7ze/zUozTA69VCk false - - 2 0 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P0C6X1-PRO_0000037301 uniprotkb:P0C6X1-PRO_0000037301 intact:EBI-25708564 intact:EBI-25708564 psi-mi:p0c6x1-pro_0000037301(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:p0c6x1-pro_0000037301(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:"MI:0114"(x-ray crystallography) Ponnusamy et al. (2008) pubmed:18694760|imex:IM-28148 taxid:11137(hcov-229e)|taxid:11137(Human coronavirus 229E) taxid:11137(hcov-229e)|taxid:11137(Human coronavirus 229E) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-25749642|pdbe:2J98|imex:IM-28148-10 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-25637276(chain-parent) intact:EBI-25637276(chain-parent) pdbe:2J97(see-also) chain-seq-start:3825|chain-seq-end:3933 chain-seq-start:3825|chain-seq-end:3933 figure legend:Table 1|comment:The conditions identified for crystallisation of the wild-type Nsp9 failed to yield crystals of the mutant, so the conditions were modified accordingly|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/06/30 2020/07/07 rogid:2LkAWeifVbpkA7btnag+3+PtMZ811137 rogid:2LkAWeifVbpkA7btnag+3+PtMZ811137 rigid:Z2KucvLeVr/N7ze/zUozTA69VCk false mutation:69-69 mutation:69-69 2 0 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P0C6X1-PRO_0000037301 uniprotkb:P0C6X1-PRO_0000037301 intact:EBI-25708564 intact:EBI-25708564 psi-mi:p0c6x1-pro_0000037301(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:p0c6x1-pro_0000037301(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:"MI:0030"(cross-linking study) Ponnusamy et al. (2008) pubmed:18694760|imex:IM-28148 taxid:11137(hcov-229e)|taxid:11137(Human coronavirus 229E) taxid:11137(hcov-229e)|taxid:11137(Human coronavirus 229E) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-25711856|imex:IM-28148-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-25637276(chain-parent) intact:EBI-25637276(chain-parent) - chain-seq-start:3825|chain-seq-end:3933 chain-seq-start:3825|chain-seq-end:3933 figure legend:Fig. 4|comment:In HCoV-229E Nsp9, the wild-type showed only monomers, dimers, and trimers.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/06/30 2020/06/30 rogid:2LkAWeifVbpkA7btnag+3+PtMZ811137 rogid:2LkAWeifVbpkA7btnag+3+PtMZ811137 rigid:Z2KucvLeVr/N7ze/zUozTA69VCk false - - 3 0 psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:P0C6X1-PRO_0000037301 uniprotkb:P0C6X1-PRO_0000037301 intact:EBI-25708564 intact:EBI-25708564 psi-mi:p0c6x1-pro_0000037301(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:p0c6x1-pro_0000037301(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:"MI:0030"(cross-linking study) Ponnusamy et al. (2008) pubmed:18694760|imex:IM-28148 taxid:11137(hcov-229e)|taxid:11137(Human coronavirus 229E) taxid:11137(hcov-229e)|taxid:11137(Human coronavirus 229E) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-25712141|imex:IM-28148-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-25637276(chain-parent) intact:EBI-25637276(chain-parent) go:"GO:0051260"(protein homooligomerization) chain-seq-start:3825|chain-seq-end:3933 chain-seq-start:3825|chain-seq-end:3933 figure legend:Fig. 4|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/06/30 2020/06/30 rogid:2LkAWeifVbpkA7btnag+3+PtMZ811137 rogid:2LkAWeifVbpkA7btnag+3+PtMZ811137 rigid:yylIPiiuRZXfAXOjJHlqQ3xqCnc false mutation:69-69 mutation:69-69 - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:P0C6U8-PRO_0000338263 uniprotkb:P0C6U8-PRO_0000338263 intact:EBI-25610723 intact:EBI-25610723 psi-mi:p0c6u8-pro_0000338263(display_long)|uniprotkb:ORF1a polyprotein(gene name synonym)|uniprotkb:1a(orf name) psi-mi:p0c6u8-pro_0000338263(display_long)|uniprotkb:ORF1a polyprotein(gene name synonym)|uniprotkb:1a(orf name) psi-mi:"MI:0030"(cross-linking study) Ponnusamy et al. (2008) pubmed:18694760|imex:IM-28148 taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-25714107|imex:IM-28148-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-15810860(chain-parent) intact:EBI-15810860(chain-parent) go:"GO:0051260"(protein homooligomerization) chain-seq-start:4118|chain-seq-end:4230 chain-seq-start:4118|chain-seq-end:4230 figure legend:Fig. 4|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/06/30 2020/06/30 rogid:djbtL5LNKDagWRnaJOlJM8BS5lU694009 rogid:djbtL5LNKDagWRnaJOlJM8BS5lU694009 rigid:HJsgoOIVmKHQpyl508D/Y5pGdmY false - - - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:P0C6X1-PRO_0000037301 uniprotkb:P0C6X1-PRO_0000037301 intact:EBI-25708564 intact:EBI-25708564 psi-mi:p0c6x1-pro_0000037301(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:p0c6x1-pro_0000037301(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name) psi-mi:"MI:0030"(cross-linking study) Ponnusamy et al. (2008) pubmed:18694760|imex:IM-28148 taxid:11137(hcov-229e)|taxid:11137(Human coronavirus 229E) taxid:11137(hcov-229e)|taxid:11137(Human coronavirus 229E) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-25748324|imex:IM-28148-8 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-25637276(chain-parent) intact:EBI-25637276(chain-parent) - chain-seq-start:3825|chain-seq-end:3933 chain-seq-start:3825|chain-seq-end:3933 figure legend:Fig. 4|comment:In HCoV-229E Nsp9, the wild-type showed only monomers, dimers, and trimers.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/06/30 2020/07/06 rogid:2LkAWeifVbpkA7btnag+3+PtMZ811137 rogid:2LkAWeifVbpkA7btnag+3+PtMZ811137 rigid:Z2KucvLeVr/N7ze/zUozTA69VCk false - - 2 0 psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)