#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9JM54	uniprotkb:P97287	intact:EBI-709183|ensembl:ENSMUSP00000025399	intact:EBI-707292|uniprotkb:D2K6L9|uniprotkb:Q3TUS0|uniprotkb:Q792P0|uniprotkb:Q9CRI4|ensembl:ENSMUSP00000044048	psi-mi:apr_mouse(display_long)|uniprotkb:Pmaip1(gene name)|psi-mi:Pmaip1(display_short)|uniprotkb:Noxa(gene name synonym)|uniprotkb:Protein Noxa(gene name synonym)	psi-mi:mcl1_mouse(display_long)|uniprotkb:Bcl-2-related protein EAT/mcl1(gene name synonym)|uniprotkb:Mcl1(gene name)|psi-mi:Mcl1(display_short)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Day et al. (2008)	imex:IM-27976|pubmed:18589438	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25596171|imex:IM-27976-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067426.1|dip:DIP-45232N|ensembl:ENSMUSG00000024521(gene)|ensembl:ENSMUST00000025399(transcript)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0005739"(mitochondrion)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009411"(response to UV)|go:"GO:0010165"(response to X-ray)|go:"GO:0010917"(negative regulation of mitochondrial membrane potential)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1900740"(positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway)|interpro:IPR024140|rcsb pdb:2JM6|rcsb pdb:2NLA|rcsb pdb:2ROD|reactome:R-MMU-111448|reactome:R-MMU-111453	refseq:NP_032588.1|dip:DIP-33343N|ensembl:ENSMUSG00000038612(gene)|ensembl:ENSMUST00000037947(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0034097"(response to cytokine)|go:"GO:0042803"(protein homodimerization activity)|rcsb pdb:2ROC|rcsb pdb:2ROD|rcsb pdb:3D7V|rcsb pdb:3IO9|rcsb pdb:4BPI|rcsb pdb:4BPJ|rcsb pdb:4G35|rcsb pdb:5KU9|rcsb pdb:5MES|rcsb pdb:5MEV|rcsb pdb:5VX2|rcsb pdb:6DM8|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0051400"(BH domain binding)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1903378"(positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR013281(Apoptosis regulator, Mcl-1)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020728|interpro:IPR026298|interpro:IPR036834|rcsb pdb:1WSX|rcsb pdb:2JM6|rcsb pdb:2NL9|rcsb pdb:2NLA	pdbe:2rod	-	-	figure legend:Fig 2, Table 1, Fig 6, Fig 7|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/05/07	2020/05/07	rogid:iK8kxdz7tYzg5/owvOIE79ObMB410090	rogid:mzEFIihn4nh/O1UVSXggXEpJOKg10090	rigid:YxEj8WrnqzThe36fZWMCUDxBKds	false	sufficient binding region:17-42	sufficient binding region:152-308	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q99ML1	uniprotkb:P97287	intact:EBI-727801|ensembl:ENSMUSP00000002152	intact:EBI-707292|uniprotkb:D2K6L9|uniprotkb:Q3TUS0|uniprotkb:Q792P0|uniprotkb:Q9CRI4|ensembl:ENSMUSP00000044048	psi-mi:bbc3_mouse(display_long)|uniprotkb:Bbc3(gene name)|psi-mi:Bbc3(display_short)|uniprotkb:Puma(gene name synonym)|uniprotkb:p53 up-regulated modulator of apoptosis(gene name synonym)	psi-mi:mcl1_mouse(display_long)|uniprotkb:Bcl-2-related protein EAT/mcl1(gene name synonym)|uniprotkb:Mcl1(gene name)|psi-mi:Mcl1(display_short)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Day et al. (2008)	imex:IM-27976|pubmed:18589438	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25596185|imex:IM-27976-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_573497.1|refseq:XP_006539640.1|refseq:XP_006539641.1|refseq:XP_006539642.1|refseq:XP_006539643.1|refseq:XP_006539644.1|refseq:XP_006539645.1|ensembl:ENSMUSG00000002083(gene)|ensembl:ENSMUST00000002152(transcript)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0005739"(mitochondrion)|go:"GO:0005740"(mitochondrial envelope)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032464"(positive regulation of protein homooligomerization)|go:"GO:0032471"(negative regulation of endoplasmic reticulum calcium ion concentration)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045926"(negative regulation of growth)|go:"GO:0051117"(ATPase binding)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1900740"(positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway)|go:"GO:1901998"(toxin transport)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR031661|rcsb pdb:2ROC|rcsb pdb:2VOF|go:"GO:0071456"(cellular response to hypoxia)|dip:DIP-29805N	refseq:NP_032588.1|dip:DIP-33343N|ensembl:ENSMUSG00000038612(gene)|ensembl:ENSMUST00000037947(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0034097"(response to cytokine)|go:"GO:0042803"(protein homodimerization activity)|rcsb pdb:2ROC|rcsb pdb:2ROD|rcsb pdb:3D7V|rcsb pdb:3IO9|rcsb pdb:4BPI|rcsb pdb:4BPJ|rcsb pdb:4G35|rcsb pdb:5KU9|rcsb pdb:5MES|rcsb pdb:5MEV|rcsb pdb:5VX2|rcsb pdb:6DM8|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0051400"(BH domain binding)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1903378"(positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR013281(Apoptosis regulator, Mcl-1)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020728|interpro:IPR026298|interpro:IPR036834|rcsb pdb:1WSX|rcsb pdb:2JM6|rcsb pdb:2NL9|rcsb pdb:2NLA	pdbe:2roc	-	-	figure legend:Fig 2, Table 1, Fig 6, Fig 7|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/05/07	2020/05/07	rogid:lq0AaGSFPd/uPIBsgkCJrSkJzNM10090	rogid:mzEFIihn4nh/O1UVSXggXEpJOKg10090	rigid:D43Osf2V4Ega695aC9oDu7CjCqw	false	sufficient binding region:130-155	sufficient binding region:152-308	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9JM54	uniprotkb:P97287	intact:EBI-709183|ensembl:ENSMUSP00000025399	intact:EBI-707292|uniprotkb:D2K6L9|uniprotkb:Q3TUS0|uniprotkb:Q792P0|uniprotkb:Q9CRI4|ensembl:ENSMUSP00000044048	psi-mi:apr_mouse(display_long)|uniprotkb:Pmaip1(gene name)|psi-mi:Pmaip1(display_short)|uniprotkb:Noxa(gene name synonym)|uniprotkb:Protein Noxa(gene name synonym)	psi-mi:mcl1_mouse(display_long)|uniprotkb:Bcl-2-related protein EAT/mcl1(gene name synonym)|uniprotkb:Mcl1(gene name)|psi-mi:Mcl1(display_short)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Day et al. (2008)	imex:IM-27976|pubmed:18589438	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25616201|imex:IM-27976-25	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067426.1|dip:DIP-45232N|ensembl:ENSMUSG00000024521(gene)|ensembl:ENSMUST00000025399(transcript)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0005739"(mitochondrion)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009411"(response to UV)|go:"GO:0010165"(response to X-ray)|go:"GO:0010917"(negative regulation of mitochondrial membrane potential)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1900740"(positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway)|interpro:IPR024140|rcsb pdb:2JM6|rcsb pdb:2NLA|rcsb pdb:2ROD|reactome:R-MMU-111448|reactome:R-MMU-111453	refseq:NP_032588.1|dip:DIP-33343N|ensembl:ENSMUSG00000038612(gene)|ensembl:ENSMUST00000037947(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0034097"(response to cytokine)|go:"GO:0042803"(protein homodimerization activity)|rcsb pdb:2ROC|rcsb pdb:2ROD|rcsb pdb:3D7V|rcsb pdb:3IO9|rcsb pdb:4BPI|rcsb pdb:4BPJ|rcsb pdb:4G35|rcsb pdb:5KU9|rcsb pdb:5MES|rcsb pdb:5MEV|rcsb pdb:5VX2|rcsb pdb:6DM8|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0051400"(BH domain binding)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1903378"(positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR013281(Apoptosis regulator, Mcl-1)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020728|interpro:IPR026298|interpro:IPR036834|rcsb pdb:1WSX|rcsb pdb:2JM6|rcsb pdb:2NL9|rcsb pdb:2NLA	-	-	-	figure legend:Fig 7|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/05/07	2020/05/20	rogid:iK8kxdz7tYzg5/owvOIE79ObMB410090	rogid:mzEFIihn4nh/O1UVSXggXEpJOKg10090	rigid:YxEj8WrnqzThe36fZWMCUDxBKds	false	sufficient binding region:68-93	sufficient binding region:152-308	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O08734	uniprotkb:P97287	intact:EBI-822441|uniprotkb:E9QM21|uniprotkb:Q8C264|ensembl:ENSMUSP00000077757	intact:EBI-707292|uniprotkb:D2K6L9|uniprotkb:Q3TUS0|uniprotkb:Q792P0|uniprotkb:Q9CRI4|ensembl:ENSMUSP00000044048	psi-mi:bak_mouse(display_long)|uniprotkb:Apoptosis regulator BAK(gene name synonym)|uniprotkb:Bak1(gene name)|psi-mi:Bak1(display_short)|uniprotkb:Bak(gene name synonym)	psi-mi:mcl1_mouse(display_long)|uniprotkb:Bcl-2-related protein EAT/mcl1(gene name synonym)|uniprotkb:Mcl1(gene name)|psi-mi:Mcl1(display_short)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Day et al. (2008)	imex:IM-27976|pubmed:18589438	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25616239|imex:IM-27976-27	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031549.2|dip:DIP-29807N|ensembl:ENSMUSG00000057789(gene)|ensembl:ENSMUST00000078691(transcript)|go:"GO:0001776"(leukocyte homeostasis)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0002352"(B cell negative selection)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007420"(brain development)|go:"GO:0007568"(aging)|go:"GO:0008053"(mitochondrial fusion)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0009620"(response to fungus)|go:"GO:0010046"(response to mycotoxin)|go:"GO:0010225"(response to UV-C)|go:"GO:0010248"(establishment or maintenance of transmembrane electrochemical gradient)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016020"(membrane)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032471"(negative regulation of endoplasmic reticulum calcium ion concentration)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035108"(limb morphogenesis)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044346"(fibroblast apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046872"(metal ion binding)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046930"(pore complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048597"(post-embryonic camera-type eye morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0051087"(chaperone binding)|go:"GO:0051400"(BH domain binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0060068"(vagina development)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070242"(thymocyte apoptotic process)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097145"(BAK complex)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1902262"(apoptotic process involved in blood vessel morphogenesis)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020728|interpro:IPR026298|interpro:IPR026308|interpro:IPR036834|rcsb pdb:2VOH|rcsb pdb:5FMJ|rcsb pdb:5KTG|rcsb pdb:6MCY|reactome:R-MMU-111452|reactome:R-MMU-111457|reactome:R-MMU-5620971	refseq:NP_032588.1|dip:DIP-33343N|ensembl:ENSMUSG00000038612(gene)|ensembl:ENSMUST00000037947(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0034097"(response to cytokine)|go:"GO:0042803"(protein homodimerization activity)|rcsb pdb:2ROC|rcsb pdb:2ROD|rcsb pdb:3D7V|rcsb pdb:3IO9|rcsb pdb:4BPI|rcsb pdb:4BPJ|rcsb pdb:4G35|rcsb pdb:5KU9|rcsb pdb:5MES|rcsb pdb:5MEV|rcsb pdb:5VX2|rcsb pdb:6DM8|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0051400"(BH domain binding)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1903378"(positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR013281(Apoptosis regulator, Mcl-1)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020728|interpro:IPR026298|interpro:IPR036834|rcsb pdb:1WSX|rcsb pdb:2JM6|rcsb pdb:2NL9|rcsb pdb:2NLA	-	-	-	figure legend:Fig. 6, Fig. 7|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/05/07	2020/05/20	rogid:T7CFw0SsDVHa+bqgyJSxkaebDBc10090	rogid:mzEFIihn4nh/O1UVSXggXEpJOKg10090	rigid:IIbi6qlCTIuv4SncAUXgzBOqrW4	false	sufficient binding region:65-90	sufficient binding region:152-308	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P97287	uniprotkb:Q9JM54	intact:EBI-707292|uniprotkb:D2K6L9|uniprotkb:Q3TUS0|uniprotkb:Q792P0|uniprotkb:Q9CRI4|ensembl:ENSMUSP00000044048	intact:EBI-709183|ensembl:ENSMUSP00000025399	psi-mi:mcl1_mouse(display_long)|uniprotkb:Bcl-2-related protein EAT/mcl1(gene name synonym)|uniprotkb:Mcl1(gene name)|psi-mi:Mcl1(display_short)	psi-mi:apr_mouse(display_long)|uniprotkb:Pmaip1(gene name)|psi-mi:Pmaip1(display_short)|uniprotkb:Noxa(gene name synonym)|uniprotkb:Protein Noxa(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Day et al. (2008)	imex:IM-27976|pubmed:18589438	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25596210|imex:IM-27976-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032588.1|dip:DIP-33343N|ensembl:ENSMUSG00000038612(gene)|ensembl:ENSMUST00000037947(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0034097"(response to cytokine)|go:"GO:0042803"(protein homodimerization activity)|rcsb pdb:2ROC|rcsb pdb:2ROD|rcsb pdb:3D7V|rcsb pdb:3IO9|rcsb pdb:4BPI|rcsb pdb:4BPJ|rcsb pdb:4G35|rcsb pdb:5KU9|rcsb pdb:5MES|rcsb pdb:5MEV|rcsb pdb:5VX2|rcsb pdb:6DM8|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0051400"(BH domain binding)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1903378"(positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR013281(Apoptosis regulator, Mcl-1)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020728|interpro:IPR026298|interpro:IPR036834|rcsb pdb:1WSX|rcsb pdb:2JM6|rcsb pdb:2NL9|rcsb pdb:2NLA	refseq:NP_067426.1|dip:DIP-45232N|ensembl:ENSMUSG00000024521(gene)|ensembl:ENSMUST00000025399(transcript)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0005739"(mitochondrion)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009411"(response to UV)|go:"GO:0010165"(response to X-ray)|go:"GO:0010917"(negative regulation of mitochondrial membrane potential)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1900740"(positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway)|interpro:IPR024140|rcsb pdb:2JM6|rcsb pdb:2NLA|rcsb pdb:2ROD|reactome:R-MMU-111448|reactome:R-MMU-111453	-	-	-	figure legend:Fig 9b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/05/07	2020/05/18	rogid:mzEFIihn4nh/O1UVSXggXEpJOKg10090	rogid:iK8kxdz7tYzg5/owvOIE79ObMB410090	rigid:YxEj8WrnqzThe36fZWMCUDxBKds	false	sufficient binding region:152-308	sufficient binding region:16-41	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P97287	uniprotkb:Q9JM54	intact:EBI-707292|uniprotkb:D2K6L9|uniprotkb:Q3TUS0|uniprotkb:Q792P0|uniprotkb:Q9CRI4|ensembl:ENSMUSP00000044048	intact:EBI-709183|ensembl:ENSMUSP00000025399	psi-mi:mcl1_mouse(display_long)|uniprotkb:Bcl-2-related protein EAT/mcl1(gene name synonym)|uniprotkb:Mcl1(gene name)|psi-mi:Mcl1(display_short)	psi-mi:apr_mouse(display_long)|uniprotkb:Pmaip1(gene name)|psi-mi:Pmaip1(display_short)|uniprotkb:Noxa(gene name synonym)|uniprotkb:Protein Noxa(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Day et al. (2008)	imex:IM-27976|pubmed:18589438	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25596210|imex:IM-27976-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032588.1|dip:DIP-33343N|ensembl:ENSMUSG00000038612(gene)|ensembl:ENSMUST00000037947(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0034097"(response to cytokine)|go:"GO:0042803"(protein homodimerization activity)|rcsb pdb:2ROC|rcsb pdb:2ROD|rcsb pdb:3D7V|rcsb pdb:3IO9|rcsb pdb:4BPI|rcsb pdb:4BPJ|rcsb pdb:4G35|rcsb pdb:5KU9|rcsb pdb:5MES|rcsb pdb:5MEV|rcsb pdb:5VX2|rcsb pdb:6DM8|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0051400"(BH domain binding)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1903378"(positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR013281(Apoptosis regulator, Mcl-1)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020728|interpro:IPR026298|interpro:IPR036834|rcsb pdb:1WSX|rcsb pdb:2JM6|rcsb pdb:2NL9|rcsb pdb:2NLA	refseq:NP_067426.1|dip:DIP-45232N|ensembl:ENSMUSG00000024521(gene)|ensembl:ENSMUST00000025399(transcript)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0005739"(mitochondrion)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009411"(response to UV)|go:"GO:0010165"(response to X-ray)|go:"GO:0010917"(negative regulation of mitochondrial membrane potential)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1900740"(positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway)|interpro:IPR024140|rcsb pdb:2JM6|rcsb pdb:2NLA|rcsb pdb:2ROD|reactome:R-MMU-111448|reactome:R-MMU-111453	-	-	-	figure legend:Fig 9b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/05/07	2020/05/18	rogid:mzEFIihn4nh/O1UVSXggXEpJOKg10090	rogid:iK8kxdz7tYzg5/owvOIE79ObMB410090	rigid:YxEj8WrnqzThe36fZWMCUDxBKds	false	sufficient binding region:152-308	sufficient binding region:16-41|mutation disrupting interaction strength:27-27|mutation disrupting interaction strength:30-30|mutation disrupting interaction strength:32-32|mutation decreasing interaction strength:34-34	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9JM54	uniprotkb:P97287	intact:EBI-709183|ensembl:ENSMUSP00000025399	intact:EBI-707292|uniprotkb:D2K6L9|uniprotkb:Q3TUS0|uniprotkb:Q792P0|uniprotkb:Q9CRI4|ensembl:ENSMUSP00000044048	psi-mi:apr_mouse(display_long)|uniprotkb:Pmaip1(gene name)|psi-mi:Pmaip1(display_short)|uniprotkb:Noxa(gene name synonym)|uniprotkb:Protein Noxa(gene name synonym)	psi-mi:mcl1_mouse(display_long)|uniprotkb:Bcl-2-related protein EAT/mcl1(gene name synonym)|uniprotkb:Mcl1(gene name)|psi-mi:Mcl1(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	Day et al. (2008)	imex:IM-27976|pubmed:18589438	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25613050|imex:IM-27976-18	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067426.1|dip:DIP-45232N|ensembl:ENSMUSG00000024521(gene)|ensembl:ENSMUST00000025399(transcript)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0005739"(mitochondrion)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009411"(response to UV)|go:"GO:0010165"(response to X-ray)|go:"GO:0010917"(negative regulation of mitochondrial membrane potential)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1900740"(positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway)|interpro:IPR024140|rcsb pdb:2JM6|rcsb pdb:2NLA|rcsb pdb:2ROD|reactome:R-MMU-111448|reactome:R-MMU-111453	refseq:NP_032588.1|dip:DIP-33343N|ensembl:ENSMUSG00000038612(gene)|ensembl:ENSMUST00000037947(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0034097"(response to cytokine)|go:"GO:0042803"(protein homodimerization activity)|rcsb pdb:2ROC|rcsb pdb:2ROD|rcsb pdb:3D7V|rcsb pdb:3IO9|rcsb pdb:4BPI|rcsb pdb:4BPJ|rcsb pdb:4G35|rcsb pdb:5KU9|rcsb pdb:5MES|rcsb pdb:5MEV|rcsb pdb:5VX2|rcsb pdb:6DM8|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0051400"(BH domain binding)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1903378"(positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR013281(Apoptosis regulator, Mcl-1)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020728|interpro:IPR026298|interpro:IPR036834|rcsb pdb:1WSX|rcsb pdb:2JM6|rcsb pdb:2NL9|rcsb pdb:2NLA	-	-	-	figure legend:Fig 9b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/05/07	2020/05/18	rogid:iK8kxdz7tYzg5/owvOIE79ObMB410090	rogid:mzEFIihn4nh/O1UVSXggXEpJOKg10090	rigid:YxEj8WrnqzThe36fZWMCUDxBKds	false	sufficient binding region:16-41	sufficient binding region:152-308	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9JM54	uniprotkb:P97287	intact:EBI-709183|ensembl:ENSMUSP00000025399	intact:EBI-707292|uniprotkb:D2K6L9|uniprotkb:Q3TUS0|uniprotkb:Q792P0|uniprotkb:Q9CRI4|ensembl:ENSMUSP00000044048	psi-mi:apr_mouse(display_long)|uniprotkb:Pmaip1(gene name)|psi-mi:Pmaip1(display_short)|uniprotkb:Noxa(gene name synonym)|uniprotkb:Protein Noxa(gene name synonym)	psi-mi:mcl1_mouse(display_long)|uniprotkb:Bcl-2-related protein EAT/mcl1(gene name synonym)|uniprotkb:Mcl1(gene name)|psi-mi:Mcl1(display_short)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Day et al. (2008)	imex:IM-27976|pubmed:18589438	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25596241|imex:IM-27976-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067426.1|dip:DIP-45232N|ensembl:ENSMUSG00000024521(gene)|ensembl:ENSMUST00000025399(transcript)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0005739"(mitochondrion)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009411"(response to UV)|go:"GO:0010165"(response to X-ray)|go:"GO:0010917"(negative regulation of mitochondrial membrane potential)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1900740"(positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway)|interpro:IPR024140|rcsb pdb:2JM6|rcsb pdb:2NLA|rcsb pdb:2ROD|reactome:R-MMU-111448|reactome:R-MMU-111453	refseq:NP_032588.1|dip:DIP-33343N|ensembl:ENSMUSG00000038612(gene)|ensembl:ENSMUST00000037947(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0034097"(response to cytokine)|go:"GO:0042803"(protein homodimerization activity)|rcsb pdb:2ROC|rcsb pdb:2ROD|rcsb pdb:3D7V|rcsb pdb:3IO9|rcsb pdb:4BPI|rcsb pdb:4BPJ|rcsb pdb:4G35|rcsb pdb:5KU9|rcsb pdb:5MES|rcsb pdb:5MEV|rcsb pdb:5VX2|rcsb pdb:6DM8|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0051400"(BH domain binding)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1903378"(positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR013281(Apoptosis regulator, Mcl-1)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020728|interpro:IPR026298|interpro:IPR036834|rcsb pdb:1WSX|rcsb pdb:2JM6|rcsb pdb:2NL9|rcsb pdb:2NLA	-	-	-	figure legend:Fig 8, Table 2|comment:"Another BH3 peptide with Kd 72.5 nM, LNoxaB,  is mentioned in \"Table 2. Thermodynamic parameters for BH3 domain peptides binding Mcl-1 determined by ITC at 25 °C\", however no additional information or its position could be retrieved from the paper."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/05/07	2020/05/07	rogid:iK8kxdz7tYzg5/owvOIE79ObMB410090	rogid:mzEFIihn4nh/O1UVSXggXEpJOKg10090	rigid:YxEj8WrnqzThe36fZWMCUDxBKds	false	sufficient binding region:68-93|mutation increasing interaction strength:74-74	sufficient binding region:152-308	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q99ML1	uniprotkb:P97287	intact:EBI-727801|ensembl:ENSMUSP00000002152	intact:EBI-707292|uniprotkb:D2K6L9|uniprotkb:Q3TUS0|uniprotkb:Q792P0|uniprotkb:Q9CRI4|ensembl:ENSMUSP00000044048	psi-mi:bbc3_mouse(display_long)|uniprotkb:Bbc3(gene name)|psi-mi:Bbc3(display_short)|uniprotkb:Puma(gene name synonym)|uniprotkb:p53 up-regulated modulator of apoptosis(gene name synonym)	psi-mi:mcl1_mouse(display_long)|uniprotkb:Bcl-2-related protein EAT/mcl1(gene name synonym)|uniprotkb:Mcl1(gene name)|psi-mi:Mcl1(display_short)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Day et al. (2008)	imex:IM-27976|pubmed:18589438	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25596263|imex:IM-27976-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_573497.1|refseq:XP_006539640.1|refseq:XP_006539641.1|refseq:XP_006539642.1|refseq:XP_006539643.1|refseq:XP_006539644.1|refseq:XP_006539645.1|ensembl:ENSMUSG00000002083(gene)|ensembl:ENSMUST00000002152(transcript)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0005739"(mitochondrion)|go:"GO:0005740"(mitochondrial envelope)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032464"(positive regulation of protein homooligomerization)|go:"GO:0032471"(negative regulation of endoplasmic reticulum calcium ion concentration)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045926"(negative regulation of growth)|go:"GO:0051117"(ATPase binding)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1900740"(positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway)|go:"GO:1901998"(toxin transport)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR031661|rcsb pdb:2ROC|rcsb pdb:2VOF|go:"GO:0071456"(cellular response to hypoxia)|dip:DIP-29805N	refseq:NP_032588.1|dip:DIP-33343N|ensembl:ENSMUSG00000038612(gene)|ensembl:ENSMUST00000037947(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0034097"(response to cytokine)|go:"GO:0042803"(protein homodimerization activity)|rcsb pdb:2ROC|rcsb pdb:2ROD|rcsb pdb:3D7V|rcsb pdb:3IO9|rcsb pdb:4BPI|rcsb pdb:4BPJ|rcsb pdb:4G35|rcsb pdb:5KU9|rcsb pdb:5MES|rcsb pdb:5MEV|rcsb pdb:5VX2|rcsb pdb:6DM8|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0051400"(BH domain binding)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1903378"(positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR013281(Apoptosis regulator, Mcl-1)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020728|interpro:IPR026298|interpro:IPR036834|rcsb pdb:1WSX|rcsb pdb:2JM6|rcsb pdb:2NL9|rcsb pdb:2NLA	-	-	-	figure legend:Fig 8, Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/05/07	2020/05/07	rogid:lq0AaGSFPd/uPIBsgkCJrSkJzNM10090	rogid:mzEFIihn4nh/O1UVSXggXEpJOKg10090	rigid:D43Osf2V4Ega695aC9oDu7CjCqw	false	sufficient binding region:130-155|mutation increasing interaction:144-144	sufficient binding region:152-308	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q91ZE9	uniprotkb:P97287	intact:EBI-708032|uniprotkb:Q8BUK0|ensembl:ENSMUSP00000159051	intact:EBI-707292|uniprotkb:D2K6L9|uniprotkb:Q3TUS0|uniprotkb:Q792P0|uniprotkb:Q9CRI4|ensembl:ENSMUSP00000044048	psi-mi:bmf_mouse(display_long)|uniprotkb:Bmf(gene name)|psi-mi:Bmf(display_short)	psi-mi:mcl1_mouse(display_long)|uniprotkb:Bcl-2-related protein EAT/mcl1(gene name synonym)|uniprotkb:Mcl1(gene name)|psi-mi:Mcl1(display_short)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Day et al. (2008)	imex:IM-27976|pubmed:18589438	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25596282|imex:IM-27976-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_612186.2|refseq:XP_006498918.1|refseq:NP_001318150.1|dip:DIP-29806N|ensembl:ENSMUSG00000040093(gene)|ensembl:ENSMUST00000125860(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005737"(cytoplasm)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016459"(myosin complex)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0034644"(cellular response to UV)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043276"(anoikis)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:1904093"(negative regulation of autophagic cell death)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR028192|mint:Q91ZE9|rcsb pdb:2VOG|reactome:R-MMU-111453|reactome:R-MMU-139910	refseq:NP_032588.1|dip:DIP-33343N|ensembl:ENSMUSG00000038612(gene)|ensembl:ENSMUST00000037947(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0034097"(response to cytokine)|go:"GO:0042803"(protein homodimerization activity)|rcsb pdb:2ROC|rcsb pdb:2ROD|rcsb pdb:3D7V|rcsb pdb:3IO9|rcsb pdb:4BPI|rcsb pdb:4BPJ|rcsb pdb:4G35|rcsb pdb:5KU9|rcsb pdb:5MES|rcsb pdb:5MEV|rcsb pdb:5VX2|rcsb pdb:6DM8|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0051400"(BH domain binding)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1903378"(positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR013281(Apoptosis regulator, Mcl-1)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020728|interpro:IPR026298|interpro:IPR036834|rcsb pdb:1WSX|rcsb pdb:2JM6|rcsb pdb:2NL9|rcsb pdb:2NLA	-	-	-	figure legend:Fig 8, Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:328.9x10^-9(molar)	2020/05/07	2020/05/07	rogid:TuX2CXkbIbnDcK+gYw7T0AyD5zo10090	rogid:mzEFIihn4nh/O1UVSXggXEpJOKg10090	rigid:tWIt8MccrLnsoeR2l+9ak84Li0A	false	sufficient binding region:126-152	sufficient binding region:152-308	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O08734	uniprotkb:P97287	intact:EBI-822441|uniprotkb:E9QM21|uniprotkb:Q8C264|ensembl:ENSMUSP00000077757	intact:EBI-707292|uniprotkb:D2K6L9|uniprotkb:Q3TUS0|uniprotkb:Q792P0|uniprotkb:Q9CRI4|ensembl:ENSMUSP00000044048	psi-mi:bak_mouse(display_long)|uniprotkb:Apoptosis regulator BAK(gene name synonym)|uniprotkb:Bak1(gene name)|psi-mi:Bak1(display_short)|uniprotkb:Bak(gene name synonym)	psi-mi:mcl1_mouse(display_long)|uniprotkb:Bcl-2-related protein EAT/mcl1(gene name synonym)|uniprotkb:Mcl1(gene name)|psi-mi:Mcl1(display_short)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Day et al. (2008)	imex:IM-27976|pubmed:18589438	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25596291|imex:IM-27976-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031549.2|dip:DIP-29807N|ensembl:ENSMUSG00000057789(gene)|ensembl:ENSMUST00000078691(transcript)|go:"GO:0001776"(leukocyte homeostasis)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0002352"(B cell negative selection)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007420"(brain development)|go:"GO:0007568"(aging)|go:"GO:0008053"(mitochondrial fusion)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0009620"(response to fungus)|go:"GO:0010046"(response to mycotoxin)|go:"GO:0010225"(response to UV-C)|go:"GO:0010248"(establishment or maintenance of transmembrane electrochemical gradient)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016020"(membrane)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032471"(negative regulation of endoplasmic reticulum calcium ion concentration)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035108"(limb morphogenesis)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044346"(fibroblast apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046872"(metal ion binding)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046930"(pore complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048597"(post-embryonic camera-type eye morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0051087"(chaperone binding)|go:"GO:0051400"(BH domain binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0060068"(vagina development)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070242"(thymocyte apoptotic process)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097145"(BAK complex)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1902262"(apoptotic process involved in blood vessel morphogenesis)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020728|interpro:IPR026298|interpro:IPR026308|interpro:IPR036834|rcsb pdb:2VOH|rcsb pdb:5FMJ|rcsb pdb:5KTG|rcsb pdb:6MCY|reactome:R-MMU-111452|reactome:R-MMU-111457|reactome:R-MMU-5620971	refseq:NP_032588.1|dip:DIP-33343N|ensembl:ENSMUSG00000038612(gene)|ensembl:ENSMUST00000037947(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0034097"(response to cytokine)|go:"GO:0042803"(protein homodimerization activity)|rcsb pdb:2ROC|rcsb pdb:2ROD|rcsb pdb:3D7V|rcsb pdb:3IO9|rcsb pdb:4BPI|rcsb pdb:4BPJ|rcsb pdb:4G35|rcsb pdb:5KU9|rcsb pdb:5MES|rcsb pdb:5MEV|rcsb pdb:5VX2|rcsb pdb:6DM8|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0051400"(BH domain binding)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1903378"(positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR013281(Apoptosis regulator, Mcl-1)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020728|interpro:IPR026298|interpro:IPR036834|rcsb pdb:1WSX|rcsb pdb:2JM6|rcsb pdb:2NL9|rcsb pdb:2NLA	-	-	-	figure legend:Fig 8, Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:2.6x10^-9(molar)	2020/05/07	2020/05/07	rogid:T7CFw0SsDVHa+bqgyJSxkaebDBc10090	rogid:mzEFIihn4nh/O1UVSXggXEpJOKg10090	rigid:IIbi6qlCTIuv4SncAUXgzBOqrW4	false	sufficient binding region:65-90	sufficient binding region:152-308	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O54918	uniprotkb:P97287	intact:EBI-526067|uniprotkb:O54919|uniprotkb:O54920|uniprotkb:A2ALQ6|ensembl:ENSMUSP00000105970	intact:EBI-707292|uniprotkb:D2K6L9|uniprotkb:Q3TUS0|uniprotkb:Q792P0|uniprotkb:Q9CRI4|ensembl:ENSMUSP00000044048	psi-mi:b2l11_mouse(display_long)|uniprotkb:Bcl2-interacting mediator of cell death(gene name synonym)|uniprotkb:Bcl2l11(gene name)|psi-mi:Bcl2l11(display_short)|uniprotkb:Bim(gene name synonym)	psi-mi:mcl1_mouse(display_long)|uniprotkb:Bcl-2-related protein EAT/mcl1(gene name synonym)|uniprotkb:Mcl1(gene name)|psi-mi:Mcl1(display_short)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Day et al. (2008)	imex:IM-27976|pubmed:18589438	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25596301|imex:IM-27976-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033884.1|refseq:NP_997563.1|refseq:NP_997564.1|ensembl:ENSMUSG00000027381(gene)|ensembl:ENSMUST00000110341(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001776"(leukocyte homeostasis)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001822"(kidney development)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007127"(meiosis I)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008584"(male gonad development)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030879"(mammary gland development)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0034263"(positive regulation of autophagy in response to ER overload)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035148"(tube formation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043583"(ear development)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0046620"(regulation of organ growth)|go:"GO:0048066"(developmental pigmentation)|go:"GO:0048070"(regulation of developmental pigmentation)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048563"(post-embryonic animal organ morphogenesis)|go:"GO:0060139"(positive regulation of apoptotic process by virus)|go:"GO:0070242"(thymocyte apoptotic process)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097140"(BIM-BCL-xl complex)|go:"GO:0097141"(BIM-BCL-2 complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1902110"(positive regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1902263"(apoptotic process involved in embryonic digit morphogenesis)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000271"(positive regulation of fibroblast apoptotic process)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR014771(Apoptosis, Bim N-terminal)|interpro:IPR015040(Bcl-x interacting)|interpro:IPR017288(Apoptosis, Bcl-2-like protein 11)|rcsb pdb:1PQ1|reactome:R-MMU-111446|reactome:R-MMU-111453|reactome:R-MMU-193648|dip:DIP-29214N	refseq:NP_032588.1|dip:DIP-33343N|ensembl:ENSMUSG00000038612(gene)|ensembl:ENSMUST00000037947(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0034097"(response to cytokine)|go:"GO:0042803"(protein homodimerization activity)|rcsb pdb:2ROC|rcsb pdb:2ROD|rcsb pdb:3D7V|rcsb pdb:3IO9|rcsb pdb:4BPI|rcsb pdb:4BPJ|rcsb pdb:4G35|rcsb pdb:5KU9|rcsb pdb:5MES|rcsb pdb:5MEV|rcsb pdb:5VX2|rcsb pdb:6DM8|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0051400"(BH domain binding)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1903378"(positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR013281(Apoptosis regulator, Mcl-1)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020728|interpro:IPR026298|interpro:IPR036834|rcsb pdb:1WSX|rcsb pdb:2JM6|rcsb pdb:2NL9|rcsb pdb:2NLA	-	-	-	figure legend:Fig 8, Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:2.1x10^-9(molar)	2020/05/07	2020/05/07	rogid:Yv0iM/Lv2orJjfRLaDKto6SFCIQ10090	rogid:mzEFIihn4nh/O1UVSXggXEpJOKg10090	rigid:+5xIzo86JBM2aQOVw+ddJ5WylaA	false	sufficient binding region:139-171	sufficient binding region:152-308	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P70444	uniprotkb:P97287	intact:EBI-783400|uniprotkb:Q99M39|ensembl:ENSMUSP00000004560|ensembl:ENSMUSP00000125731	intact:EBI-707292|uniprotkb:D2K6L9|uniprotkb:Q3TUS0|uniprotkb:Q792P0|uniprotkb:Q9CRI4|ensembl:ENSMUSP00000044048	psi-mi:bid_mouse(display_long)|uniprotkb:p22 BID(gene name synonym)|uniprotkb:Bid(gene name)|psi-mi:Bid(display_short)	psi-mi:mcl1_mouse(display_long)|uniprotkb:Bcl-2-related protein EAT/mcl1(gene name synonym)|uniprotkb:Mcl1(gene name)|psi-mi:Mcl1(display_short)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Day et al. (2008)	imex:IM-27976|pubmed:18589438	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25596311|imex:IM-27976-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031570.2|ensembl:ENSMUSG00000004446(gene)|ensembl:ENSMUST00000004560(transcript)|ensembl:ENSMUST00000160684(transcript)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0002931"(response to ischemia)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007420"(brain development)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0016020"(membrane)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032592"(integral component of mitochondrial membrane)|go:"GO:0034263"(positive regulation of autophagy in response to ER overload)|refseq:XP_006505472.1|refseq:XP_006505473.1|refseq:XP_006505474.1|dip:DIP-29808N|go:"GO:0034349"(glial cell apoptotic process)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0090150"(establishment of protein localization to membrane)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0097345"(mitochondrial outer membrane permeabilization)|go:"GO:1902108"(regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000271"(positive regulation of fibroblast apoptotic process)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR010479(BH3 interacting)|interpro:IPR020728|interpro:IPR036834|mint:P70444|rcsb pdb:1DDB|rcsb pdb:2VOI|reactome:R-MMU-111447|reactome:R-MMU-111452|reactome:R-MMU-111453|reactome:R-MMU-114294|reactome:R-MMU-75108	refseq:NP_032588.1|dip:DIP-33343N|ensembl:ENSMUSG00000038612(gene)|ensembl:ENSMUST00000037947(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0034097"(response to cytokine)|go:"GO:0042803"(protein homodimerization activity)|rcsb pdb:2ROC|rcsb pdb:2ROD|rcsb pdb:3D7V|rcsb pdb:3IO9|rcsb pdb:4BPI|rcsb pdb:4BPJ|rcsb pdb:4G35|rcsb pdb:5KU9|rcsb pdb:5MES|rcsb pdb:5MEV|rcsb pdb:5VX2|rcsb pdb:6DM8|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0051400"(BH domain binding)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1903378"(positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR013281(Apoptosis regulator, Mcl-1)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020728|interpro:IPR026298|interpro:IPR036834|rcsb pdb:1WSX|rcsb pdb:2JM6|rcsb pdb:2NL9|rcsb pdb:2NLA	-	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:9.8x10^-9(molar)	2020/05/07	2020/05/07	rogid:wP7rDKvhdigb9+nzg+E2e6K+FY410090	rogid:mzEFIihn4nh/O1UVSXggXEpJOKg10090	rigid:O3mybc4+AvwwmB+vhgJ4DM9OrP4	false	sufficient binding region:?-?	sufficient binding region:152-308	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9JM54	uniprotkb:P97287	intact:EBI-709183|ensembl:ENSMUSP00000025399	intact:EBI-707292|uniprotkb:D2K6L9|uniprotkb:Q3TUS0|uniprotkb:Q792P0|uniprotkb:Q9CRI4|ensembl:ENSMUSP00000044048	psi-mi:apr_mouse(display_long)|uniprotkb:Pmaip1(gene name)|psi-mi:Pmaip1(display_short)|uniprotkb:Noxa(gene name synonym)|uniprotkb:Protein Noxa(gene name synonym)	psi-mi:mcl1_mouse(display_long)|uniprotkb:Bcl-2-related protein EAT/mcl1(gene name synonym)|uniprotkb:Mcl1(gene name)|psi-mi:Mcl1(display_short)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Day et al. (2008)	imex:IM-27976|pubmed:18589438	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25615523|imex:IM-27976-23	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067426.1|dip:DIP-45232N|ensembl:ENSMUSG00000024521(gene)|ensembl:ENSMUST00000025399(transcript)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0005739"(mitochondrion)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009411"(response to UV)|go:"GO:0010165"(response to X-ray)|go:"GO:0010917"(negative regulation of mitochondrial membrane potential)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1900740"(positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway)|interpro:IPR024140|rcsb pdb:2JM6|rcsb pdb:2NLA|rcsb pdb:2ROD|reactome:R-MMU-111448|reactome:R-MMU-111453	refseq:NP_032588.1|dip:DIP-33343N|ensembl:ENSMUSG00000038612(gene)|ensembl:ENSMUST00000037947(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0034097"(response to cytokine)|go:"GO:0042803"(protein homodimerization activity)|rcsb pdb:2ROC|rcsb pdb:2ROD|rcsb pdb:3D7V|rcsb pdb:3IO9|rcsb pdb:4BPI|rcsb pdb:4BPJ|rcsb pdb:4G35|rcsb pdb:5KU9|rcsb pdb:5MES|rcsb pdb:5MEV|rcsb pdb:5VX2|rcsb pdb:6DM8|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0051400"(BH domain binding)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1903378"(positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR013281(Apoptosis regulator, Mcl-1)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020728|interpro:IPR026298|interpro:IPR036834|rcsb pdb:1WSX|rcsb pdb:2JM6|rcsb pdb:2NL9|rcsb pdb:2NLA	-	-	-	figure legend:Fig 8, Table 2|comment:"Another BH3 peptide with Kd 72.5 nM, LNoxaB,  is mentioned in \"Table 2. Thermodynamic parameters for BH3 domain peptides binding Mcl-1 determined by ITC at 25 °C\", however no additional information or its position could be retrieved from the paper."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/05/07	2020/05/20	rogid:iK8kxdz7tYzg5/owvOIE79ObMB410090	rogid:mzEFIihn4nh/O1UVSXggXEpJOKg10090	rigid:YxEj8WrnqzThe36fZWMCUDxBKds	false	sufficient binding region:17-42	sufficient binding region:152-308	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P97287	uniprotkb:Q9JM54	intact:EBI-707292|uniprotkb:D2K6L9|uniprotkb:Q3TUS0|uniprotkb:Q792P0|uniprotkb:Q9CRI4|ensembl:ENSMUSP00000044048	intact:EBI-709183|ensembl:ENSMUSP00000025399	psi-mi:mcl1_mouse(display_long)|uniprotkb:Bcl-2-related protein EAT/mcl1(gene name synonym)|uniprotkb:Mcl1(gene name)|psi-mi:Mcl1(display_short)	psi-mi:apr_mouse(display_long)|uniprotkb:Pmaip1(gene name)|psi-mi:Pmaip1(display_short)|uniprotkb:Noxa(gene name synonym)|uniprotkb:Protein Noxa(gene name synonym)	psi-mi:"MI:0084"(phage display)	Day et al. (2008)	imex:IM-27976|pubmed:18589438	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25613117|imex:IM-27976-20	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032588.1|dip:DIP-33343N|ensembl:ENSMUSG00000038612(gene)|ensembl:ENSMUST00000037947(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0034097"(response to cytokine)|go:"GO:0042803"(protein homodimerization activity)|rcsb pdb:2ROC|rcsb pdb:2ROD|rcsb pdb:3D7V|rcsb pdb:3IO9|rcsb pdb:4BPI|rcsb pdb:4BPJ|rcsb pdb:4G35|rcsb pdb:5KU9|rcsb pdb:5MES|rcsb pdb:5MEV|rcsb pdb:5VX2|rcsb pdb:6DM8|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0051400"(BH domain binding)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1903378"(positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR013281(Apoptosis regulator, Mcl-1)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020728|interpro:IPR026298|interpro:IPR036834|rcsb pdb:1WSX|rcsb pdb:2JM6|rcsb pdb:2NL9|rcsb pdb:2NLA	refseq:NP_067426.1|dip:DIP-45232N|ensembl:ENSMUSG00000024521(gene)|ensembl:ENSMUST00000025399(transcript)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0005739"(mitochondrion)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009411"(response to UV)|go:"GO:0010165"(response to X-ray)|go:"GO:0010917"(negative regulation of mitochondrial membrane potential)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1900740"(positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway)|interpro:IPR024140|rcsb pdb:2JM6|rcsb pdb:2NLA|rcsb pdb:2ROD|reactome:R-MMU-111448|reactome:R-MMU-111453	-	-	-	figure legend:Fig. 9a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/05/07	2020/05/20	rogid:mzEFIihn4nh/O1UVSXggXEpJOKg10090	rogid:iK8kxdz7tYzg5/owvOIE79ObMB410090	rigid:YxEj8WrnqzThe36fZWMCUDxBKds	false	sufficient binding region:152-308	sufficient binding region:16-41|mutation with no effect:16-16|mutation with no effect:17-17|mutation with no effect:18-18|mutation with no effect:19-19|mutation with no effect:20-20|mutation with no effect:21-21|mutation with no effect:22-22|mutation with no effect:23-23|mutation with no effect:24-24|mutation with no effect:25-25|mutation with no effect:26-26|mutation disrupting interaction strength:27-27|mutation with no effect:28-28|mutation with no effect:29-29|mutation disrupting interaction strength:30-30|mutation disrupting interaction strength:31-31|mutation disrupting interaction strength:32-32|mutation with no effect:33-33|mutation disrupting interaction strength:34-34|mutation with no effect:35-35|mutation with no effect:36-36|mutation with no effect:37-37|mutation with no effect:38-38|mutation with no effect:39-39|mutation with no effect:40-40|mutation with no effect:41-41	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P97287	uniprotkb:Q9JM54	intact:EBI-707292|uniprotkb:D2K6L9|uniprotkb:Q3TUS0|uniprotkb:Q792P0|uniprotkb:Q9CRI4|ensembl:ENSMUSP00000044048	intact:EBI-709183|ensembl:ENSMUSP00000025399	psi-mi:mcl1_mouse(display_long)|uniprotkb:Bcl-2-related protein EAT/mcl1(gene name synonym)|uniprotkb:Mcl1(gene name)|psi-mi:Mcl1(display_short)	psi-mi:apr_mouse(display_long)|uniprotkb:Pmaip1(gene name)|psi-mi:Pmaip1(display_short)|uniprotkb:Noxa(gene name synonym)|uniprotkb:Protein Noxa(gene name synonym)	psi-mi:"MI:0084"(phage display)	Day et al. (2008)	imex:IM-27976|pubmed:18589438	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25613117|imex:IM-27976-20	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032588.1|dip:DIP-33343N|ensembl:ENSMUSG00000038612(gene)|ensembl:ENSMUST00000037947(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0034097"(response to cytokine)|go:"GO:0042803"(protein homodimerization activity)|rcsb pdb:2ROC|rcsb pdb:2ROD|rcsb pdb:3D7V|rcsb pdb:3IO9|rcsb pdb:4BPI|rcsb pdb:4BPJ|rcsb pdb:4G35|rcsb pdb:5KU9|rcsb pdb:5MES|rcsb pdb:5MEV|rcsb pdb:5VX2|rcsb pdb:6DM8|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0051400"(BH domain binding)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1903378"(positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR013281(Apoptosis regulator, Mcl-1)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020728|interpro:IPR026298|interpro:IPR036834|rcsb pdb:1WSX|rcsb pdb:2JM6|rcsb pdb:2NL9|rcsb pdb:2NLA	refseq:NP_067426.1|dip:DIP-45232N|ensembl:ENSMUSG00000024521(gene)|ensembl:ENSMUST00000025399(transcript)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0005739"(mitochondrion)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009411"(response to UV)|go:"GO:0010165"(response to X-ray)|go:"GO:0010917"(negative regulation of mitochondrial membrane potential)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1900740"(positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway)|interpro:IPR024140|rcsb pdb:2JM6|rcsb pdb:2NLA|rcsb pdb:2ROD|reactome:R-MMU-111448|reactome:R-MMU-111453	-	-	-	figure legend:Fig. 9a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/05/07	2020/05/20	rogid:mzEFIihn4nh/O1UVSXggXEpJOKg10090	rogid:iK8kxdz7tYzg5/owvOIE79ObMB410090	rigid:YxEj8WrnqzThe36fZWMCUDxBKds	false	sufficient binding region:152-308	sufficient binding region:16-41	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9JM54	uniprotkb:P97287	intact:EBI-709183|ensembl:ENSMUSP00000025399	intact:EBI-707292|uniprotkb:D2K6L9|uniprotkb:Q3TUS0|uniprotkb:Q792P0|uniprotkb:Q9CRI4|ensembl:ENSMUSP00000044048	psi-mi:apr_mouse(display_long)|uniprotkb:Pmaip1(gene name)|psi-mi:Pmaip1(display_short)|uniprotkb:Noxa(gene name synonym)|uniprotkb:Protein Noxa(gene name synonym)	psi-mi:mcl1_mouse(display_long)|uniprotkb:Bcl-2-related protein EAT/mcl1(gene name synonym)|uniprotkb:Mcl1(gene name)|psi-mi:Mcl1(display_short)	psi-mi:"MI:0084"(phage display)	Day et al. (2008)	imex:IM-27976|pubmed:18589438	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25615374|imex:IM-27976-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067426.1|dip:DIP-45232N|ensembl:ENSMUSG00000024521(gene)|ensembl:ENSMUST00000025399(transcript)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0005739"(mitochondrion)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009411"(response to UV)|go:"GO:0010165"(response to X-ray)|go:"GO:0010917"(negative regulation of mitochondrial membrane potential)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1900740"(positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway)|interpro:IPR024140|rcsb pdb:2JM6|rcsb pdb:2NLA|rcsb pdb:2ROD|reactome:R-MMU-111448|reactome:R-MMU-111453	refseq:NP_032588.1|dip:DIP-33343N|ensembl:ENSMUSG00000038612(gene)|ensembl:ENSMUST00000037947(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0034097"(response to cytokine)|go:"GO:0042803"(protein homodimerization activity)|rcsb pdb:2ROC|rcsb pdb:2ROD|rcsb pdb:3D7V|rcsb pdb:3IO9|rcsb pdb:4BPI|rcsb pdb:4BPJ|rcsb pdb:4G35|rcsb pdb:5KU9|rcsb pdb:5MES|rcsb pdb:5MEV|rcsb pdb:5VX2|rcsb pdb:6DM8|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0051400"(BH domain binding)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1903378"(positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR013281(Apoptosis regulator, Mcl-1)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020728|interpro:IPR026298|interpro:IPR036834|rcsb pdb:1WSX|rcsb pdb:2JM6|rcsb pdb:2NL9|rcsb pdb:2NLA	-	-	-	figure legend:Fig. 9a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/05/07	2020/05/20	rogid:iK8kxdz7tYzg5/owvOIE79ObMB410090	rogid:mzEFIihn4nh/O1UVSXggXEpJOKg10090	rigid:YxEj8WrnqzThe36fZWMCUDxBKds	false	sufficient binding region:16-41	sufficient binding region:152-308	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)