#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
chebi:"CHEBI:15633"	uniprotkb:P00383	intact:EBI-25764584|chebi:"CHEBI:14150"|chebi:"CHEBI:42000"|chebi:"CHEBI:12245"|chebi:"CHEBI:4564"|chebi:"CHEBI:20768"	intact:EBI-25642610	psi-mi:dihydrofolic acid(display_short)|psi-mi:"CHEBI:15633"(display_long)|intact:7,8-Dihydrofolate(synonym)|intact:7,8-Dihydrofolic acid(synonym)|intact:7,8-Dihydropteroylglutamate(synonym)|intact:Dihydrofolate(synonym)|intact:Dihydrofolic acid(synonym)|intact:"N-(7,8-dihydropteroyl)-L-glutamic acid"(synonym)|intact:"N-(4-{[(2-amino-4-oxo-3,4,7,8-tetrahydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid"(iupac name)	psi-mi:dyr21_ecolx(display_long)|uniprotkb:Dihydrofolate reductase type II(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Krahn et al. (2007)	pubmed:18052202|imex:IM-28222	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:562(ecolx)|taxid:562(Escherichia coli)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25642632|imex:IM-28222-1|pdbe:2rk1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0004146"(dihydrofolate reductase activity)|go:"GO:0006730"(one-carbon metabolic process)|go:"GO:0031427"(response to methotrexate)|go:"GO:0042493"|go:"GO:0046654"(tetrahydrofolate biosynthetic process)|go:"GO:0046677"(response to antibiotic)|refseq:WP_000442373.1|rcsb pdb:1VIE|rcsb pdb:1VIF|rcsb pdb:2GQV|rcsb pdb:2P4T|rcsb pdb:2RH2|rcsb pdb:2RK1|rcsb pdb:2RK2|rcsb pdb:3SFM|rcsb pdb:6NXZ|rcsb pdb:6NY0|interpro:IPR009159(Dihydrofolate reductase, type II)|interpro:IPR008990(Electron transport accessory protein)|interpro:IPR023408	-	-	-	figure legend:Fig. 4a|3d-resolution:1.26|3d-r-factors:12.3/15.2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/06/11	2020/07/31	-	rogid:zgO4IxeC3YpFd38upuxV3OBTCEM562	-	false	-	sufficient binding region:17-78	1	4	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:15633"	chebi:"CHEBI:25523"	intact:EBI-25764584|chebi:"CHEBI:14150"|chebi:"CHEBI:42000"|chebi:"CHEBI:12245"|chebi:"CHEBI:4564"|chebi:"CHEBI:20768"	intact:EBI-8874319	psi-mi:dihydrofolic acid(display_short)|psi-mi:"CHEBI:15633"(display_long)|intact:7,8-Dihydrofolate(synonym)|intact:7,8-Dihydrofolic acid(synonym)|intact:7,8-Dihydropteroylglutamate(synonym)|intact:Dihydrofolate(synonym)|intact:Dihydrofolic acid(synonym)|intact:"N-(7,8-dihydropteroyl)-L-glutamic acid"(synonym)|intact:"N-(4-{[(2-amino-4-oxo-3,4,7,8-tetrahydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid"(iupac name)	psi-mi:nadp(display_short)|psi-mi:"CHEBI:25523"(display_long)|intact:nicotinamide-adenine dinucleotide phosphate(synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Krahn et al. (2007)	pubmed:18052202|imex:IM-28222	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25642632|imex:IM-28222-1|pdbe:2rk1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0328"(small molecule)	-	-	-	-	-	figure legend:Fig. 4a|3d-resolution:1.26|3d-r-factors:12.3/15.2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/06/11	2020/07/31	-	-	-	false	-	-	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:25523"	uniprotkb:P00383	intact:EBI-8874319	intact:EBI-25642610	psi-mi:nadp(display_short)|psi-mi:"CHEBI:25523"(display_long)|intact:nicotinamide-adenine dinucleotide phosphate(synonym)	psi-mi:dyr21_ecolx(display_long)|uniprotkb:Dihydrofolate reductase type II(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Krahn et al. (2007)	pubmed:18052202|imex:IM-28222	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:562(ecolx)|taxid:562(Escherichia coli)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25642643|imex:IM-28222-3|pdbe:2rk2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0004146"(dihydrofolate reductase activity)|go:"GO:0006730"(one-carbon metabolic process)|go:"GO:0031427"(response to methotrexate)|go:"GO:0042493"|go:"GO:0046654"(tetrahydrofolate biosynthetic process)|go:"GO:0046677"(response to antibiotic)|refseq:WP_000442373.1|rcsb pdb:1VIE|rcsb pdb:1VIF|rcsb pdb:2GQV|rcsb pdb:2P4T|rcsb pdb:2RH2|rcsb pdb:2RK1|rcsb pdb:2RK2|rcsb pdb:3SFM|rcsb pdb:6NXZ|rcsb pdb:6NY0|interpro:IPR009159(Dihydrofolate reductase, type II)|interpro:IPR008990(Electron transport accessory protein)|interpro:IPR023408	-	-	-	figure legend:Fig. 4a|3d-resolution:1.9|3d-r-factors:14.1/2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/06/11	2020/07/31	-	rogid:zgO4IxeC3YpFd38upuxV3OBTCEM562	-	false	-	sufficient binding region:17-78	1	4	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P00383	uniprotkb:P00383	intact:EBI-25642610	intact:EBI-25642610	psi-mi:dyr21_ecolx(display_long)|uniprotkb:Dihydrofolate reductase type II(gene name synonym)	psi-mi:dyr21_ecolx(display_long)|uniprotkb:Dihydrofolate reductase type II(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Krahn et al. (2007)	pubmed:18052202|imex:IM-28222	taxid:562(ecolx)|taxid:562(Escherichia coli)	taxid:562(ecolx)|taxid:562(Escherichia coli)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25642654|imex:IM-28222-5|pdbe:2rh2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0004146"(dihydrofolate reductase activity)|go:"GO:0006730"(one-carbon metabolic process)|go:"GO:0031427"(response to methotrexate)|go:"GO:0042493"|go:"GO:0046654"(tetrahydrofolate biosynthetic process)|go:"GO:0046677"(response to antibiotic)|refseq:WP_000442373.1|rcsb pdb:1VIE|rcsb pdb:1VIF|rcsb pdb:2GQV|rcsb pdb:2P4T|rcsb pdb:2RH2|rcsb pdb:2RK1|rcsb pdb:2RK2|rcsb pdb:3SFM|rcsb pdb:6NXZ|rcsb pdb:6NY0|interpro:IPR009159(Dihydrofolate reductase, type II)|interpro:IPR008990(Electron transport accessory protein)|interpro:IPR023408	go:"GO:0004146"(dihydrofolate reductase activity)|go:"GO:0006730"(one-carbon metabolic process)|go:"GO:0031427"(response to methotrexate)|go:"GO:0042493"|go:"GO:0046654"(tetrahydrofolate biosynthetic process)|go:"GO:0046677"(response to antibiotic)|refseq:WP_000442373.1|rcsb pdb:1VIE|rcsb pdb:1VIF|rcsb pdb:2GQV|rcsb pdb:2P4T|rcsb pdb:2RH2|rcsb pdb:2RK1|rcsb pdb:2RK2|rcsb pdb:3SFM|rcsb pdb:6NXZ|rcsb pdb:6NY0|interpro:IPR009159(Dihydrofolate reductase, type II)|interpro:IPR008990(Electron transport accessory protein)|interpro:IPR023408	-	-	-	figure legend:Fig. 4a|3d-resolution:0.96|3d-r-factors:10.3/11.7|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/06/11	2020/07/31	rogid:zgO4IxeC3YpFd38upuxV3OBTCEM562	rogid:zgO4IxeC3YpFd38upuxV3OBTCEM562	rigid:hAabUKf21MXuwiPTfQJRmiON7kg	false	sufficient binding region:17-78	sufficient binding region:17-78	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)